CN109430721A - A kind of wheat embryo composition and preparation method thereof with hypoglycemic effect - Google Patents

A kind of wheat embryo composition and preparation method thereof with hypoglycemic effect Download PDF

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Publication number
CN109430721A
CN109430721A CN201811210867.4A CN201811210867A CN109430721A CN 109430721 A CN109430721 A CN 109430721A CN 201811210867 A CN201811210867 A CN 201811210867A CN 109430721 A CN109430721 A CN 109430721A
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parts
wheat embryo
composition
seed
purslane
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欧阳继东
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GUANGZHOU HAOXIAOXIN MEDICAL EQUIPMENT Co Ltd
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GUANGZHOU HAOXIAOXIN MEDICAL EQUIPMENT Co Ltd
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L7/00—Cereal-derived products; Malt products; Preparation or treatment thereof
    • A23L7/10—Cereal-derived products
    • A23L7/152—Cereal germ products
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
    • A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/683—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols
    • A61K31/685—Diesters of a phosphorus acid with two hydroxy compounds, e.g. phosphatidylinositols one of the hydroxy compounds having nitrogen atoms, e.g. phosphatidylserine, lecithin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7016—Disaccharides, e.g. lactose, lactulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716—Glucans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258—Panax (ginseng)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/537—Salvia (sage)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8964—Anemarrhena
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8968—Ophiopogon (Lilyturf)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/899—Poaceae or Gramineae (Grass family), e.g. bamboo, corn or sugar cane
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Abstract

The invention discloses a kind of wheat embryo composition and preparation method thereof with function of blood sugar reduction.The present composition is mainly made of conventional Chinese medicines and soybean lecithin, oligoisomaltose, xylitol and avenabeta glucosan etc. such as wheat embryo, odd sub- seed, purslane, rhizoma anemarrhenae, Radix Notoginseng, Radix Ophiopogonis, the integrally-regulated advantage of Chinese medicine compound prescription is played, there is significant effect of lowering blood sugar.Experiment confirms its blood glucose level that hyperglycemia model mouse can be effectively reduced, and improves the sugar tolerance of diabetic mice, and has little effect to the blood glucose of normal mouse, therefore there is the present composition significant auxiliary hyperglycemic function can safely and effectively take for a long time.

Description

A kind of wheat embryo composition and preparation method thereof with hypoglycemic effect
Technical field
The wheat embryo composition and its specific preparation method that the present invention relates to a kind of with hypoglycemic effect.
Background technique
Diabetes be because body insulin secretion relative or absolute deficiency causes blood glucose excessively high, caused by with protein and Fat metabolic disturbance is the common endocrine metabolism disease of one kind of main clinical manifestation.As aging of population, environment are dirty The influence of the factors such as dye, undesirable life style and stress, diabetes have become the common multiple of many countries in the whole world Disease, the death rate are even more the third position occupied after tumour, angiocarpy.China's diabetic's quantity ranks the first in the world, and wherein About 95% is patients with NIDDM, and clinical data is shown, 10 years or so after onset diabetes, will there is the patient of 30%-40% A kind of complication can at least occur, and complication, once generating, drug therapy is difficult to reverse, heavy bear can be brought to family Load.
The method for the treatment of diabetes is mostly oral administration of metformin or sulfonylurea hypoglycemic agent and insulin injection at present, is worked Fastly, but often palliative, long-term use can generate larger side effect to body, if malpractice is even easy to cause sternly The complication of weight.Since synthetic drug has more adverse reaction and contraindication, the World Health Organization advocates research and development and uses Natural plant composition treats type II diabetes.
Diabetes are known as " diabetes " in terms of theory of traditional Chinese medical science, and the clinic that traditional Chinese medicine prevention diabetes possess thousands of years is real It tramples, compared with Western medicine, although Chinese medicine blood sugar reducing function is relatively slow, it is intracorporal integrally-regulated to can promote people, and blood sugar reducing function Persistently, there is Western medicine irreplaceable role.Have effects that auxiliary hyperglycemic because the invention is a kind of and adjusts the guarantor of physical function Health food reduces diabetic and takes the side effect of Western medicine generation and reduce complication risk, reduces the pain of diabetic Hardship has the good market demand and realistic meaning.Therefore the invention proposes a kind of wheat embryos with hypoglycemic effect Composition and its specific preparation method.
Summary of the invention
The wheat embryo composition and its specific preparation that the purpose of the present invention is to provide a kind of with hypoglycemic effect Method, the composition are made of the bulk pharmaceutical chemicals of following parts by weight: 40-50 parts of wheat embryo, odd 5-10 parts of the seed in Asia, and purslane 3-7 Part, 3-7 parts of rhizoma anemarrhenae, 3-7 parts of Radix Notoginseng, Radix Ophiopogonis 3-7 part, 0.1-0.5 parts of soybean lecithin, 1-5 parts of oligoisomaltose, xylitol 1-5 parts, 1-5 parts of avenabeta glucosan.
The weight part ratio of present composition bulk pharmaceutical chemicals is preferred are as follows: and 40 parts of wheat embryo, odd 10 parts of the seed in Asia, 3 parts of purslane, 7 parts of rhizoma anemarrhenae, 5 parts of Radix Notoginseng, 5 parts of Radix Ophiopogonis, 0.5 part of soybean lecithin, 3 parts of oligoisomaltose, 5 parts of xylitol, oat β-Portugal is poly- 1 part of sugar.
The weight part ratio of present composition bulk pharmaceutical chemicals is also preferably: 45 parts of wheat embryo, odd 8 parts of the seed in Asia, and purslane 5 Part, 5 parts of rhizoma anemarrhenae, 3 parts of Radix Notoginseng, 7 parts of Radix Ophiopogonis, 0.25 part of soybean lecithin, 1 part of oligoisomaltose, 3 parts of xylitol, oat β- 5 parts of glucan.
The weight part ratio of present composition bulk pharmaceutical chemicals is also preferably: 50 parts of wheat embryo, odd 5 parts of the seed in Asia, and purslane 7 Part, 3 parts of rhizoma anemarrhenae, 7 parts of Radix Notoginseng, 3 parts of Radix Ophiopogonis, 0.1 part of soybean lecithin, 5 parts of oligoisomaltose, 1 part of xylitol, oat β-Portugal 3 parts of glycan.
Wheat embryo is a part of wheat seed, accounts for about the 2.5% of wheat quality, contains most of nutrition of wheat Ingredient contains extremely abundant and good protein, fat, multivitamin and minerals, is described as " the mankind by nutritionists Natural nutrition treasure-house ".The protein content of wheat embryo is up to 30%, and wheat plantule protein is a kind of natural good complete Albumen containing 8 kinds of amino acid needed by human, amino acid overall balance, and is easily absorbed by the human body.Wheat-germ oil is rich in Asia The unsaturated fatty acids such as oleic acid, linolenic acid and phosphatide, having enhances mental, stable nerve, balance endocrine, delays senescence, mentions The effects of high immunity and regeneration power.Glutathione and content of vitamin E contained therein is abundant, have anti-oxidant, anti-aging, Enhancing blood circulation, the effect for preventing artery sclerosis.
Odd Asia seed originates from Mexico and Guatemala, is the seed of chia, eats with a long history, has so far More than 5500 years history.Odd Asia seed is rich in high-quality protein, n-3 polyunsaturated fatty acid, soluble dietary fiber, vitamin, mine Substance and a variety of anti-oxidizing compounds have and adjust blood lipid, adjust blood glucose, adjust blood pressure, auxiliary weight-reducing, prevention cardiovascular and cerebrovascular The various functions such as disease.Odd Asia seed can not only have blood glucose by the conduction of increase sugar tolerance and promotion insulin signaling certain Regulatory function, and because it is rich in dietary fiber, the digestion and absorption of carbohydrate can be slowed down, extend alpha-amylase pair The enzymolysis time of starch plays the role of reducing blood glucose.
Purslane is common medical and edible dual purpose plant, nature and flavor acid, cold, the function with clearing heat and detoxicating, cooling blood and hemostasis, stop dysentery Effect, for toxic-heat and blood stasis, carbuncle, swelling and furuncle, eczema, erysipelas, hematochezia etc..Wherein main chemical component is polysaccharide, flavonoids, terpene Class, Coumarins, alkaloids and organic acid etc., modern pharmacological studies have shown that it is with anti-bacteria and anti-virus, anti-oxidant, tune blood Rouge promotes pancreatic secretion insulin, adjusts human body glycometabolism, reduce blood sugar concentration, keep a variety of pharmacological activity such as blood glucose is constant. Pharmacological evaluation confirms polysaccharide, alkaloid and the Polyphenols component of purslane, all has obvious hypoglycemic activity.
Rhizoma anemarrhenae is the dry rhizome of liliaceae plant, and bitter, sweet, cold in nature, return lung, stomach, kidney channel have enriching yin drop The effect of fire, the sliding dry, relieving restlessness of quenching the thirst of ease constipation, sharp stool and urine.Modern studies have found that rhizoma anemarrhenae has reducing blood lipid, hypoglycemic, antipyretic, anti- Scorching, antiviral, antithrombotic and anticancer and other effects, experiment display rhizoma anemarrhenae polyphenols can also inhibit the work of alpha-glucosidase Property, inhibit the degradation of the carbohydrates such as starch in food, reduces small intestine to the uptake of glucose.
Radix Notoginseng category Araliaceae Panax perennial herb plant, traditional effect are hemostasis, dissipate the stasis of blood, detumescence, analgesic, benefit Void etc..It contains there are many chemical component, such as saponins, polysaccharide, flavonoids, sterol and organic acid, wherein main medicinal Ingredient is saponins compound.Modern pharmacological research finds Radix Notoginseng, and with improving, immunity, raising memory, liver protection is anti-inflammatory, expands Open the pharmacological activity such as blood vessel, antithrombotic, antitumor, anti-aging, hypoglycemic.Pharmacological evaluation finds that Radix Notoginseng can be to alloxan glycosuria Sick animal model has apparent blood sugar reducing function, illustrates that it has certain hypoglycemic effect.
Radix Ophiopogonis belongs to liliaceous plant Radix Ophiopogonis dried root, is China's traditional Chinese medicine, returns stomach, the heart, lung channel, mildly bitter flavor and Sweet, cold nature, primary efficacy is heart clearing, lung moistening, yin-nourishing of promoting the production of body fluid, and is mainly used for treating pharyngeal diphtheria, dryness of the lung dry cough, injury thirst, interior Heat quenches one's thirst, cough due to consumptive disease, vexed and constipation intestinal dryness of having a sleepless night etc..The effective component type of Radix Ophiopogonis mainly has saponin(e, flavones, amino acid With polysaccharide etc., have resist myocardial ischemia, antithrombus formation, anti-inflammatory, hypoglycemic, antitumor, anti-oxidant, enhancing is immune, improves liver The pharmacological actions such as injury of lungs and antibechic.Related pharmacological evaluation discovery, ophiopogonpolysaccharide can inhibit absorption of the mouse intestinal to glucose, Inhibit the decomposition of internal glycogen, accelerate inhibition of the islet B cell to insulin secretion speed, plays the role of reducing blood glucose.
Soybean lecithin also known as soybean lecithin, the sticky very high hair of oil-containing of the one kind obtained when being refining of edible soybean oil Phosphatide has very unique function and effect.Modern pharmacological studies have shown that soybean lecithin has reduction human serum gallbladder solid Alcohol improves fat metabolism, prevents artery sclerosis, anti-aging, enhancing memory and the effect for preventing and treating diabetes.Soybean lecithin Lipid-loweringing definite principle, effect is reliable, be free from side effects, and the function of cell can also be improved, improve the metabolic capability of cell, Energy needed for supplying body.
Oligoisomaltose is a kind of functional oligose, has the characteristic of sugar, but cannot be by saliva and gastrointestinal tract Hydrolase is decomposed, therefore is not digested and assimilated by body and be directly entered large intestine, is preferentially utilized, can be promoted by Bifidobacterium The proliferation and proportion of intestinal beneficial bacterium inhibit harmful intestinal tract bacteria and corrupt substance to be formed.Oligoisomaltose can promote benefit Raw bacterium generates short chain fatty acids and short chain organic acid, reduces intestinal pH, promotes intestines peristalsis, improves constipation, increases vitamin and contains Amount promotes the absorption of minerals, improves immunity of organisms, plays a significant role to maintenance body health level.
Xylitol is a kind of natural sweetener and human body that can be extracted from the plants such as corncob, bagasse The intermediate of normal sugar metabolism, xylitol can effectively participate in the metabolic activity of human body, and not needing can by insulin To enter in cell, and the speed of its metabolism is relatively fast, will not cause the raising of patient blood glucose's value, therefore have one to blood glucose Fixed control action.
Avenabeta glucosan is a kind of soluble dietary fiber, positioned at the aleurone and sub- aleurone of oat, has and adjusts Blood glucose reduces cholesterol, improves the effects of immunity, anticancer.It is not easily digested after avenabeta glucosan is edible, Viscous solution is formed in enteron aisle can hinder the absorption of glucide, delay blood sugar concentration to increase, reduce postprandial blood sugar and insulin It is horizontal.
Present composition formula is made of two groups of raw materials, wherein one group mainly by wheat embryo, odd sub- seed, purslane, The raw material composition mainly based on the traditional Chinese medicine such as rhizoma anemarrhenae, Radix Notoginseng and Radix Ophiopogonis, each material combination generate synergistic effect together, heighten the effect of a treatment, The integrally-regulated advantage of Chinese medicine compound prescription is played, there is good effect of lowering blood sugar.Another group of raw material be added to soybean lecithin and Oligoisomaltose, xylitol, avenabeta glucosan etc. have the substance of auxiliary hyperglycemic effect.Two groups of raw materials are comprehensive to play drop Blood glucose effect, and without side-effects and adverse reaction, have apparent advantage.
The present composition mainly consists of the following steps:
(1) raw material is weighed according to bulk pharmaceutical chemicals weight ratio, cleaned；
(2) purslane, rhizoma anemarrhenae and Radix Ophiopogonis are put into Chinese medicament extracting device, the 8-10 times of water measured is added, is mentioned in slightly boiled situation It takes and decocts 1-2h, extract 2-3 times, mix resulting extracting solution every time, filtration is condensed into thick paste, is dried under reduced pressure and is ground into thin Powder, it is spare；
(3) wheat embryo, odd sub- seed and Radix Notoginseng are crushed with micronizer, is collected micro mist (crossing 300 mesh), it is spare；
(4) by soybean lecithin, the oligomeric different malt of micro mist and corresponding proportion obtained by fine powder obtained by step (2), step (3) Sugar, xylitol and avenabeta glucosan be uniformly mixed to get.
The dosage form of the present composition is oral powder, tablet, capsule or granule.
Specific embodiment
Below with reference to embodiment, technical solution of the present invention is further illustrated.
Embodiment 1
Prescription: 40 parts of wheat embryo, odd 10 parts of the seed in Asia, 3 parts of purslane, 7 parts of rhizoma anemarrhenae, 5 parts of Radix Notoginseng, 5 parts of Radix Ophiopogonis, soybean ovum .5 parts of phosphatidase 0,3 parts of oligoisomaltose, 5 parts of xylitol, 1 part of avenabeta glucosan.
Preparation method:
(1) raw material is weighed according to bulk pharmaceutical chemicals weight ratio, cleaned；
(2) purslane, rhizoma anemarrhenae and Radix Ophiopogonis are put into Chinese medicament extracting device, the water of 8 times of amounts is added, extracts and decocts in slightly boiled situation 2h is boiled, is extracted 3 times, resulting extracting solution every time is mixed, filtration is condensed into thick paste, is dried under reduced pressure and is ground into fine powder, spare；
(3) wheat embryo, odd sub- seed and Radix Notoginseng are crushed with micronizer, is collected micro mist (crossing 300 mesh), it is spare；
(4) by soybean lecithin, the oligomeric different malt of micro mist and corresponding proportion obtained by fine powder obtained by step (2), step (3) Sugar, xylitol and avenabeta glucosan be uniformly mixed to get.
Embodiment 2
Prescription: 45 parts of wheat embryo, odd 8 parts of the seed in Asia, 5 parts of purslane, 5 parts of rhizoma anemarrhenae, 3 parts of Radix Notoginseng, 7 parts of Radix Ophiopogonis, soybean ovum .25 parts of phosphatidase 0,1 part of oligoisomaltose, 3 parts of xylitol, 5 parts of avenabeta glucosan.
Preparation method:
(1) raw material is weighed according to bulk pharmaceutical chemicals weight ratio, cleaned；
(2) purslane, rhizoma anemarrhenae and Radix Ophiopogonis are put into Chinese medicament extracting device, the water of 9 times of amounts is added, extracts and decocts in slightly boiled situation 1.5h is boiled, is extracted 2 times, resulting extracting solution every time is mixed, filtration is condensed into thick paste, is dried under reduced pressure and is ground into fine powder, standby With；
(3) wheat embryo, odd sub- seed and Radix Notoginseng are crushed with micronizer, is collected micro mist (crossing 300 mesh), it is spare；
(4) by soybean lecithin, the oligomeric different malt of micro mist and corresponding proportion obtained by fine powder obtained by step (2), step (3) Sugar, xylitol and avenabeta glucosan be uniformly mixed to get.
Embodiment 3
Prescription: 50 parts of wheat embryo, odd 5 parts of the seed in Asia, 7 parts of purslane, 3 parts of rhizoma anemarrhenae, 7 parts of Radix Notoginseng, 3 parts of Radix Ophiopogonis, soybean ovum .1 parts of phosphatidase 0,5 parts of oligoisomaltose, 1 part of xylitol, 3 parts of avenabeta glucosan.
Preparation method:
(1) raw material is weighed according to bulk pharmaceutical chemicals weight ratio, cleaned；
(2) purslane, rhizoma anemarrhenae and Radix Ophiopogonis are put into Chinese medicament extracting device, the water of 10 times of amounts is added, is extracted in slightly boiled situation 1h is decocted, is extracted 3 times, resulting extracting solution every time is mixed, filtration is condensed into thick paste, is dried under reduced pressure and is ground into fine powder, standby With；
(3) wheat embryo, odd sub- seed and Radix Notoginseng are crushed with micronizer, is collected micro mist (crossing 300 mesh), it is spare；
(4) by soybean lecithin, the oligomeric different malt of micro mist and corresponding proportion obtained by fine powder obtained by step (2), step (3) Sugar, xylitol and avenabeta glucosan be uniformly mixed to get.
In order to confirm that it is hypoglycemic that wheat embryo composition of the present invention has the function of, by the combination obtained of 2 method of embodiment Object has carried out animal experiment study:
1 experimental material
1.1 reagents are by wheat embryo composition made from 2 condition of embodiment；Experimental animal are as follows: weight be 18g~ The Kunming 22g kind male white mouse, is purchased from Guangdong Province's Experimental Animal Center.
1.2 instruments and reagent
Rotary evaporator RE252C (Shanghai Yarong Biochemical Instrument Plant)；(the general analysis in Beijing is logical for TU-1810 ultraviolet specrophotometer With instrument Co., Ltd)；SHZ-D circulating water type vacuum pump (Ying Yu Yu Hua instrument plant, Gongyi City)；The superior blood glucose inspection of Roche Survey instrument and Test paper (Roche Diagnostics GmbH).Alloxan (Fluka product)；Metformin hydrochloride tablet (Beijing Fourth Ring Pharmaceutical Co. Ltd)；Sodium chloride injection (0.9%) (Siyao Co., Ltd., Shijiazhuang)；Liquor epinephrinae bitartratis ophthalmicus noradrenaline Plain (Shanghai He Feng pharmaceutical Co. Ltd).
2 experimental methods
Blood sugar reducing function of 2.1 compositions to the hyperglycemia model mouse of model induced by alloxan
Hyperglycemia mouse is randomly divided into glycosuria after modeling success by diabetic mice modeling method caused by alloxan Disease model group (MCG), positive controls (PCG, Metformin hydrochloride are administered by 125mg/kgd), composition treatment group (ZHW), respectively by the dosage administration of 200,400,600mg/kgd, Normal group (NCG) is 10 healthy mices, glycosuria Disease model group and Normal group are given isometric physiological saline (NS), successive administration 14d, and 1 time/d, and make a record.14th After its administration, mouse fasting 12h, tail vein takes blood, measures blood-sugar content.
Blood sugar reducing function of 2.2 compositions to adrenaline-induced hyperglycosemia rats
Normal group (NCG) and adrenaline group (MOD) are given same amount of normal saline (NS), small after administration in the 14th day After mouse fasting 12h, gastric infusion 2h in addition to NCG group injecting normal saline, remaining presses 2mg/kg intraperitoneal injection noradrenaline Element, after 30min, tail vein takes blood, measures blood-sugar content.
2.3 compositions are led to the influence of hyperglycemia model sugar tolerance to glucose
50 model induced by alloxan hyperglycemia mouse are taken, 12h is deprived of food but not water before last dose, after 3h is administered, give Portugal Grape sugar 2.5g/kgbw stomach-filling, using the blood of 30,60,120min when Roche superior blood-sugar detecting instrument measurement stomach-filling and after stomach-filling Sugar variation.
Influence of 2.4 compositions to normal mouse blood glucose level
Observation selection healthy mice 50, the isometric physiological saline of control group stomach-filling, 1 time/d, successive administration 14d, respectively 0,7,14d after administration, tail vein take blood, measure blood-sugar content.
2.5 data processings are for statistical analysis using SPSS17.0, and measured value is with mean+SDTable Show, is analyzed using One-Way ANOVA.Using P < 0.05 or P < 0.01 as significant difference or the standard of extremely significant difference.
3 experimental results
Hypoglycemic effect of 3.1 compositions to the hyperglycemia model mouse of model induced by alloxan
Grouping situation of the composition to the research of the hypoglycemic effect of the hyperglycemia model mouse of model induced by alloxan, processing side Method and blood sugar detection the results are shown in Table 1.Table 1 is shown, after administration 14 days, positive controls fasting blood-glucose content and hyperglycemia model group (MCG) compared to extremely significant horizontal (P < 0.01) has been reached, composition each group mouse's blood sugar content decreases, the blood of low dose group Sugared value is compared with MCG group, and difference is not significant (P>0.05), middle and high dosage group significant difference (P<0.05), but middle and high dosage group Treatment level of the fasting blood sugar well below medicine group, it is seen then that diabetic mice hyperglycemia water can be effectively reduced in the composition It is flat, and show certain dose-effect relationship.
Influence of 1 composition of table to alloxan diabetes mouse fasting blood-glucose
Note: NS is physiological saline；Compared with Normal group**P<0.01；Compared with hyperglycemia model group,#P < 0.05,##P <0.01。
Blood sugar reducing function of 3.2 compositions to adrenaline-induced hyperglycosemia rats
Composition surveys grouping situation, processing method and the blood glucose of the blood sugar reducing function research of adrenaline-induced hyperglycosemia rats Surely 2 be the results are shown in Table.Table 2 shows, composition is low, middle group with adrenaline model group compared with, difference not significantly (P > 0.05), high agent Amount group significant difference (P < 0.05), but blood glucose value is above positive controls, shows that the composition has on certain inhibition kidney Parathyrine mouse blood sugar raising effect, and high dose group inhibitory effect is better than low dose group.
Blood sugar reducing function of 2 composition of table to adrenaline-induced hyperglycosemia rats
Note: NS is physiological saline；Compared with Normal group,**P<0.01；Compared with adrenaline model group,#P< 0.05,##P<0.01。
Influence of 3.3 compositions to the sugar tolerance of diabetic mice
The variation of hyperglycemia glucose tolerance in mice is shown in Table 3 after composition stomach-filling 2 weeks.(0min) each group blood glucose value relatively connects when beginning Closely, over time, though ZHW is low, middle dose group has the tendency that improving sugar tolerance, difference is not significant compared with MCG group (P>0.05)；When 30min, high dose group has the trend lower than MCG group, when 60,120min, high dose group blood glucose value and MCG Group, which is compared, to be occurred significant difference (P < 0.05), treatment level of the high dose group close to medicine group.It can be seen that the composition can be compared with Good improvement diabetic mice sugar tolerance.
Influence of 3 composition of table to model induced by alloxan diabetic mice sugar tolerance
Note: NS is physiological saline；Compared with hyperglycemia model group*P < 0.05,**P<0.01；With Metformin hydrochloride group ratio Compared with #P < 0.05.
Influence of 3.4 compositions to normal mouse blood glucose
Composition the results are shown in Table 4 to normal mouse blood sugar influence.Table 4 is shown, after continuous gavage 2 weeks, positive controls (PCG), it will be apparent that reduce mouse euglycemia (P < 0.01), compared with the control group, difference is or not the blood glucose value of composition each group Significantly (P > 0.05), it is seen that the composition will not have an impact the blood glucose value of normal mouse.
Influence of 4 composition of table to normal mouse blood glucose
4 conclusions
The middle and high dosage group of this studies have shown that the composition can reduce the hyperglycemia model mouse of model induced by alloxan Fasting blood sugar, while composition high dose group can reduce the blood glucose level of adrenaline-induced hyperglycosemia rats, composition Each dosage group can improve the sugar tolerance of diabetic mice, while on normal mouse blood glucose without influence, illustrate that this composition has Significant hypoglycemic effect.

Claims (7)

1. a kind of wheat embryo composition and preparation method thereof with function of blood sugar reduction, it is characterised in that by following parts by weight Raw material is made: 40-50 parts of wheat embryo, odd 5-10 parts of the seed in Asia, and 3-7 parts of purslane, 3-7 parts of rhizoma anemarrhenae, 3-7 parts of Radix Notoginseng, Radix Ophiopogonis 3-7 Part, 0.1-0.5 parts of soybean lecithin, 1-5 parts of oligoisomaltose, 1-5 parts of xylitol, 1-5 parts of avenabeta glucosan.
2. composition according to claim 1, it is characterised in that be made of the raw material of following parts by weight: wheat embryo 40 Part, odd 10 parts of the seed in Asia, 3 parts of purslane, 7 parts of rhizoma anemarrhenae, 5 parts of Radix Notoginseng, 5 parts of Radix Ophiopogonis, 0.5 part of soybean lecithin, oligoisomaltose 3 Part, 5 parts of xylitol, 1 part of avenabeta glucosan.
3. composition according to claim 1, it is characterised in that be made of the bulk pharmaceutical chemicals of following parts by weight: wheat embryo 45 Part, odd 8 parts of the seed in Asia, 5 parts of purslane, 5 parts of rhizoma anemarrhenae, 3 parts of Radix Notoginseng, 7 parts of Radix Ophiopogonis, 0.25 part of soybean lecithin, oligoisomaltose 1 Part, 3 parts of xylitol, 5 parts of avenabeta glucosan.
4. composition according to claim 1, it is characterised in that be made of the bulk pharmaceutical chemicals of following parts by weight: wheat embryo 50 Part, odd 5 parts of the seed in Asia, 7 parts of purslane, 3 parts of rhizoma anemarrhenae, 7 parts of Radix Notoginseng, 3 parts of Radix Ophiopogonis, 0.1 part of soybean lecithin, oligoisomaltose 5 Part, 1 part of xylitol, 3 parts of avenabeta glucosan.
5. composition according to claim 1-4, it is characterised in that the composition is mainly by following steps group At:
(1) raw material is weighed according to bulk pharmaceutical chemicals weight ratio, cleaned；
(2) purslane, rhizoma anemarrhenae and Radix Ophiopogonis are put into Chinese medicament extracting device, the 8-10 times of water measured is added, extracts and decocts in slightly boiled situation 1-2h is boiled, is extracted 2-3 times, resulting extracting solution every time is mixed, filtration is condensed into thick paste, is dried under reduced pressure and is ground into fine powder, standby With；
(3) wheat embryo, odd sub- seed and Radix Notoginseng are crushed with micronizer, is collected micro mist (crossing 300 mesh), it is spare；
(4) by the soybean lecithin of micro mist obtained by fine powder, step (3) obtained by step (2) and corresponding proportion, oligoisomaltose, Xylitol and avenabeta glucosan be uniformly mixed to get.
6. composition according to claim 5, it is characterised in that: the dosage form of composition is oral powder or preparation.
7. composition according to claim 6, it is characterised in that: oral preparation is selected from tablet, capsule, granule.
CN201811210867.4A 2018-10-17 2018-10-17 A kind of wheat embryo composition and preparation method thereof with hypoglycemic effect Withdrawn CN109430721A (en)

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