CN107260946A - A kind of health-care edible capsule preparation method with auxiliary hyperglycemic function - Google Patents

A kind of health-care edible capsule preparation method with auxiliary hyperglycemic function Download PDF

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CN107260946A
CN107260946A CN201710606216.6A CN201710606216A CN107260946A CN 107260946 A CN107260946 A CN 107260946A CN 201710606216 A CN201710606216 A CN 201710606216A CN 107260946 A CN107260946 A CN 107260946A
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parts
health
ginseng
tuber
weed
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史青友
吴喆
史颢晨
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Jilin Youth Morning Pharmaceutical Co Ltd
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Jilin Youth Morning Pharmaceutical Co Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
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    • A—HUMAN NECESSITIES
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    • A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258—Panax (ginseng)
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/42—Cucurbitaceae (Cucumber family)
    • A61K36/424—Gynostemma
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8964—Anemarrhena
    • A—HUMAN NECESSITIES
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    • A61K9/00—Medicinal preparations characterised by special physical form
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    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
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    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
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    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying

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Abstract

The invention discloses a kind of health-care edible capsule preparation method with auxiliary hyperglycemic function, inventive features are a kind of new can safely and effectively to play the hypoglycemia healthcare food of hypoglycemic effect, with reference to tradition and modernity theory of traditional Chinese medical science, pass through supplementing qi and nourishing yin, the effect of promoting the production of body fluid to quench thirst, it have developed using the wind-weed, the tuber of dwarf lilyturf, gynostemma pentaphylla, ginseng, chromium yeast as the auxiliary hyperglycemic product of raw material, improve the generation of complication therefore improve the purpose of user's quality of life.Present invention design is from supplementing qi and nourishing yin, promote the production of body fluid to quench thirst effect classical rare integration of drinking and medicinal herbs genunie medicinal materials be raw material, ensure that there is product security, validity, quality controllability to be formed using modernization processing extraction technique is refined, concentration effective component group is extracted in locking, reduce dose again, and have simultaneously be easy to carry about with one, it is convenient to take the features such as.The safe and effective test ratified and carried out through the relevant authoritative department of country.Its property of medicine is gently favorably improved the quality of life of diabetic patients.

Description

A kind of health-care edible capsule preparation method with auxiliary hyperglycemic function
First, technical field：
Belong to medicines and health protection food technology field the present invention relates to one kind, specifically, be related to a kind of for hypoglycemic Health food technology of preparing.
2nd, background technology introduction：
Diabetes are a kind of metabolic disorder diseases of synthesis, and its course of disease is long, and its caused complication is to body Each system, cell function and vigor can cause damage, wherein, hyperglycaemia can trigger a variety of harm, such as malnutritive, blood The many places artery such as pipe hardening, histocyte anoxic, renal lesions, cataract, eye-blurred, DPN, the heart, brain, lower limb is hard Change, hyperlipidemia, hypertension etc., and the aging of body can be accelerated.Therefore, control blood glucose, reduction blood glucose trigger to hyperglycaemia Complication patient is extremely important.
As the epidemic disease of the world today, common disease, its incidence of disease rises year by year.In recent years, the World Health Organization (WHO) it is classified as the non-contagious chronic diseases relevant with life style.Because diabetes are chronic, systemic, lifelong Property disease, it is changeable if Morbidity control is bad, then can trigger a variety of chronic complicating diseases, therefore be frequently referred to " origin of hundreds of diseases ".According to system There is more than 60,000,000 hyperglycaemia and diabetic in meter, China, and the whole world has 3,200,000 people's causes of the death relevant with diabetes every year. The existing 2.2 hundred million maturity-onset diabetes patients in the whole world in 2005, expert estimates 2025, will increase to 3.5 hundred million.Wherein the overwhelming majority is Non-Insulin Dependent Diabetes Mellitus is 0.9% fast by 1980 in Non-Insulin Dependent Diabetes Mellitus, more than 25 years old population of China Speed rises to the 2.5% of nineteen ninety-five, estimates 2015 and can reach 8%.So quick spreading trend, brings heavy to society Disease Spectrum, about 50,000,000,000 yuans of the social resources consumed every year.Therefore, effectively control diabetes turn into medical field Extremely urgent task.
While increasing people is perplexed by diabetes and complication, more seriously diabetes are difficult root at present Control, China's blood glucose control number up to standard is only a quarter, and medicine is maintained and the development of symptom management is treatment Main body, this has meant that a big chunk patient needs Long-term taking medicine, but long-term prescription is often also easy to produce dependence again, and has Certain toxic side effect, therefore, it is possible to safely and effectively reduce blood glucose simultaneously and can alleviate the product of its complication increasingly by To the concern of people.This product aiming at the current hyperglycemia population of China the need for develop have auxiliary hyperglycemic act on Functional food.
The hypoglycemic product occurred in the market is mainly made up of orally-taken blood sugar reducing Western medicine and the major class of insulin two, long-term clothes With being also easy to produce drug resistance, and easily bounce-back.The damage of the organs such as the heart, brain, kidney is caused after Most patients long-term taking hypoglycemic Western medicine Evil, and the medicine of the class of insulin one, curative effect is fine in a short time, but the aging of long easy acceleration islet function, damages pancreas islet group Knit, can also induce multiple complications.If excessively kept on a diet, human body constitution will be made increasingly weak, premunition declines, simultaneously Complication is also more easy to occur.Say that diabetes will not be lethal from medical angle, fearful is harm caused by diabetic complication, sternly The health and influence quality of life of people is threatened again.It is diabetes complicated according to the relevant diabetologist statistical confirmation of the World Health Organization Disease to the harm of human body considerably beyond diabetes in itself.And herbal toxic effect is small, action temperature and persistently, with comprehensive adjustment Effect, and have the advantages that to delay complication, it can yet be regarded as and find an important channel of antihypelipidemic product.
With the fast continual development of national economy, urban and rural residents of China meals, nutrition condition have obvious improvement, high The food of fatty, high heat is more and more, simultaneously because the high development of industrial technology, physical work is usually replaced by machine, Physical exertion is fewer and fewer, and the problems such as thing followed is unbalance trophic structure and shortage motion is caused non-infectious, chronic The generation of the diseases such as metabolic syndrome, wherein diabetes are the larger class diseases of harmfulness, have severely impacted people Physical and mental health.
The diabetes spp traditional Chinese medical science " is quenched one's thirst " category, and motherland's medical science thinks diabetes mainly due to the ferritic deficiency of Yin, in addition diet Do not save, caused by disorder of emotion and labor are intended to excessively.Due to addiction delicious food and pure wine savoury, taste are injured, transporting is unbalance, leads to stomach Heat, the paddy that disappears hinders Tianjin, or because of labor degree to be lost, consumption hinders healthy tendency, and the easypro cloth of body fluid is not normal.The traditional Chinese medical science thinks, the lung being the upper source of fluids, cure mainly section, Respectful drop；Dry-heat impairing lung, controls section dereliction of duty water failing to be transformed into body fluid, directly rises descending, therefore frequent urination amount is more；Lung not cloth Tianjin, therefore see thirsty；Stomach is Reservoir of food and drink, scorching to injure one's stomach, exuberance of stomach fire, therefore rapid digestion of food and polyorexia, excess heat hinders Tianjin, therefore constipation；The spleen being the foundation of acquired constitution, main fortune Change, insufficiency of the spleen transporting mistake department, changes of water paddy be precise and tiny, thus more than eating it is counter see become thin, it is weak；Kidney is source, scorching to be impairment of the kidney, kidney yang under water Virtual loss, gasify it is not normal, have no right admittedly taking the photograph, folding mistakes degree, and therefore urine frequency measure it is many.Transformation of body flaud, regulating fluid apssage is received the water that becomes thoroughly decomposed Paddy, defeated cloth water paddy it is precise and tiny, be the dirty coefficient result of lung spleen kidney three.It can thus be appreciated that its interpretation of the cause, onset and process of an illness is using the deficiency of Yin as this, it is scorching to be Mark, therefore should be promoted the production of body fluid to quench thirst with supplementing qi and nourishing yin as the rules for the treatment of.
This product is directed to the etiology and pathogenesis of " quenching one's thirst ", the requirement according to health food regulation to raw material, with theory of traditional Chinese medical science and Based on pharmacological research achievement, with reference to proved recipe and clinical application experience, the wind-weed, the tuber of dwarf lilyturf, gynostemma pentaphylla, ginseng, chromium ferment are finally determined Mother is this product raw material, and raw material is used according to as follows in side：
The wind-weed, is the dry rhizome of the liliaceous plant wind-weed.Bitter, sweet, cold in nature, return lung, stomach, kidney channel.Contain polysaccharide, soap The compositions such as glycosides, with clearing heat-fire, the effect of fluid dryness, clinic is mainly used in fever caused by exogenous pathogenic factors, hyperpyrexia polydipsia, lung-heat type cough, The diseases such as Heat Diabetes (limit etc., 1995).Li Chunmei etc. (2005) researchs find that timosaponin is made to normal mouse without hypoglycemic With, but glucose tolerance curve can be made to tend towards stability, timosaponin can significantly improve diabetic mice sugar tolerance, the experimental sugar of reduction The fasting blood-glucose of the sick mouse of urine, shows that timosaponin has certain blood sugar reducing function.Huang Fang etc. (2005) experimental study shows, from The total polyphenols isolated are extracted in Anemarrhena asphodeloides Bge has good hypoglycemic effect, and therefrom isolates mangiferin, Neomangiferin With pull out contract sapogenin, by vitro to alpha-glucosidase Inhibition test research show that mangiferin has preferable alpha-glucosaccharase Enzyme inhibition.Yellow bright cloud etc. (2004) proves that anemaran (AM) can be reduced dose-dependently by animal experiment study Alloxan-diabetes Rabbits ' Blood Sugar, and smaller is influenceed on normal Rabbits ' Blood Sugar, AM is hypoglycemic compared with orinase, makees Fast with the time, the duration is short, and its hypoglycemic effect mechanism is initially believed that may be relevant with the utilization of increase glucose, promotes fat Intake of the fat tissue to glucose, reduces blood glucose, so as to produce hypoglycemic effect.Wang Jing etc. (1996), which is studied, to be shown, the wind-weed Polysaccharide can be such that the blood glucose and liver glycogen content of mouse substantially reduces.Modern pharmacological research shows that separation and Extraction goes out four from the wind-weed The Rhizoma anemarrhenae polysaccharide of different molecular weight is planted, there is significant hypoglycemic effect, and Rhizoma anemarrhenae polysaccharide can reduce normal mouse and four oxygen Pyrimidine induce diabetes rat blood glucose, moreover it is possible to mitigate the islet tissue that alloxan is caused infringement (Lu Shenghua etc., 2003)。
The tuber of dwarf lilyturf, is the dried root of the liliaceous plant tuber of dwarf lilyturf.Sweet, slight bitter, is slightly cold, the thoughts of returning home, lung, stomach.With yin-nourishing life Tianjin, effect of moistening lung clears away heart-fire.In the tuber of dwarf lilyturf contain a variety of steroid saponins, flavone compound, polysaccharide, sodium, potassium, calcium, magnesium, iron, copper, The trace elements such as cobalt, chromium, titanium, manganese, lead, nickel, strontium, vanadium and zinc, BETA-Sitosterol etc..Wang Zhijie etc. (2003), which is studied, to be shown, Ophiopogonpolysaccharide has suppression to make the hyperglycaemia of glucose, adrenaline, three kinds of hyperglycemia model mouse of alloxan in the tuber of dwarf lilyturf With also there is obvious hypoglycemic effect to normal mouse.Ophiopogonpolysaccharide can substantially suppress in the tuber of dwarf lilyturf of Yan Quanxiang (2004) researchs Hyperglycaemia caused by glucose, adrenaline, also there is obvious hypoglycemic effect to normal mouse.Zhang Weixing etc. (1993) is ground Study carefully and show that oral ophiopogonpolysaccharide has reduction effect to normal mouse and experimental hyperglycemia.Ophiopogon japonicus extract can be reduced substantially normally Mouse blood sugar concentration, but insulin concentration is had not significant impact；After ophiopogon japonicus extract 100mg/kg administrations 4h, diabetes can be made Mouse blood sugar concentration is substantially reduced (P ＜ 0.05)；Blood sugar concentration is caused substantially to reduce to adrenaline, BM group blood glucose is significantly lower than Control group (P ＜ 0.01) (woods dawn etc., 2004).Gao Changkun etc. (2007), which is studied, to be shown, the dwarf lilyturf tuber total saponins extracted from the tuber of dwarf lilyturf, There is obvious hypoglycemic effect to the mouse hyperglycaemia caused by alloxan, adrenaline and glucose, this shows the tuber of dwarf lilyturf total soap Glycosides can weaken the function for the beta Cell of islet that damage or improvement of the alloxan to beta Cell of islet are damaged, and dwarf lilyturf tuber total saponins can be short of money Adrenolytic blood glucose increasing effect, may be relevant with suppressing decomposition of glycogen.Chen Weihui etc. (1998) researchs show ophiopogonpolysaccharide There is inhibitory action to mouse hyperglycaemia caused by glucose, alloxan and adrenaline.
Gynostemma pentaphylla, is the herb of cucurbitaceous plant gynostemma pentaphylla.It is cold in nature, bitter；Return lung, spleen, kidney channel.With eliminating inflammation and expelling toxin, Promote the production of body fluid to quench thirst, effect of nourishing and fit keeping function.Contain gypenoside, flavones, carbohydrate, several amino acids, vitamin etc..Research shows Gypenoside has no significant effect to the fasting blood-glucose of normal rat, insulin, but can significantly reduce diabetes rat fasting blood Sugar and insulin level, as treatment time extends, its blood sugar reducing function gradually strengthens (Chen Hongwei etc., 1997).Wei Shourong etc. (2005) research shows that gynostemma pentaphylla polysaccharide can reduce the fasting blood-glucose and resistance to sugar amount of alloxan hyperglycemic rat, its hypoglycemic mechanism The release of insulin may be stimulated with it or promotees inflammation of pancreatic islet and is recovered, suppresses alpha-amylase, delays carbohydrate in the suction of small intestine Receive relevant.Fat metabolism is can also adjust, prevents lipid in the deposition of vascular wall, resists glucocorticoid side effect, increase body fluid Immune and cellular immunity function.Wang Juntang etc. (1998) uses Jiaogulan in treating diabetes patient, it is found that the medicine has obvious drop Blood glucose is acted on, and acts on close with glibenclamide, total effective rate is also close, gynostemma pentaphylla and glibenclamide use in conjunction, and hypoglycemic effect is more Significantly.Chen little Hua (1998) is effective with Jiaogulan in treating diabete, can reach preferable control.
Ginseng, is the drying root and rhizome of Araliaceae ginseng.Sweet, slight bitter, mild-natured, returns spleen, lung, the heart channel of Hang-Shaoyin, has Reinforce vital energy, the effects such as promoting the production of body fluid to quench thirst.Ginseng contains saponin(e, carbohydrate, protein, amino acid, organic acid, vitamin and micro member Element etc..Xu Chengshui etc. (2003) have studied influence of the ginseng to experimental diabetic rats blood sugar level, as a result show, experimental group The blood sugar level of rat is substantially less than control group, fully shows that ginseng has obvious hypoglycemic effect.Bao Tiantong (1981) is ground Study carefully and show that contained ginsenoside can substantially suppress the blood glucose rise after animal injection alloxan in ginseng, and curative effect can after drug withdrawal Maintain 1~2 week.Su Wulin etc. (1994) researchs show that Ginseng Anti-Diabetes Capsule is small to adrenaline hyperglycaemia rabbit, alloxan Mouse diabetes have obvious blood sugar reducing function.The research such as Zheng Yinan shows that ginseng extract and ginsenoside have drop to diabetes rat Blood glucose is acted on.Yang Ming etc. (1990) result of study shows that different approaches give panaxan (GH1) to normal mouse blood sugar and glycogen First content has reduction effect, 10 and 20 minutes after panaxan is injected to mouse, serum insulin can be promoted to discharge.
Chromium yeast, chromium is to maintain the trace element needed for normal carbohydrate and lipid metaboli, and assist insulin remains normal resistance to Sugar amount.Chromium deficiency can cause the resistance to sugar amount reduction of antibody, cause blood glucose rise, glucose in urine occur.Chromium yeast be by brewer's yeast with What inorganic trivalent chromium was generated under certain condition, the content of its Organic Chromium is higher.Trivalent chromium can be formed with biological living in vivo Property organic double compound, be one kind " collaboration hormone " of insulin as GTF, GTF participate in Insulin ternary complex and membrane receptor are formed, makes insulin function stable, suppresses insulinase, amount of insulin can be maintained, and Enhancing and the combination (Xi Qingli etc., 2006) of insulin receptor.Research show chromium can reduce alloxan induction diabetes it is small Blood glucose (sweet prestige of shaking etc., 2006 of mouse；Deng Yan Shen etc., 1994).Chromium yeast can strengthen four oxygen of diabetic mice sugar tolerance and reduction Blood glucose (Wu Jianfeng etc., 1997 of pyrimidine, the diabetic mice of Streptozotocin induction；Yan Ting etc., 2007；Zhang Hongxin etc., 2007).Chromium yeast can reduce the blood glucose of diabetic, but there was only adjustment effect to the blood glucose of the normal person of blood glucose, not reduce Euglycemia (often red etc., 1994).
In summary, wind-weed clearing heat-fire, fluid dryness in we；Tuber of dwarf lilyturf nourishing Yin and promoting production of body fluid, moistening lung clears away heart-fire；Gynostemma pentaphylla is promoted the production of body fluid Quench the thirst, nourishing and fit keeping function；Ginseng reinforces vital energy, and promotes the production of body fluid to quench thirst；Again plus chromium yeast can improve glycometabolism.All medicine compatibilities, play QI invigorating altogether Yin-nourishing, the effect of promoting the production of body fluid to quench thirst, so as to reach auxiliary hyperglycemic, improves the purpose of user's quality of life.
The associated documents that security of the present invention is used according to healthy food material carry out prescription, and raw material meets the requirements.Examine Consider long-term consumption security and validity.Chromium yeast meets《Vitamin, the species of mineral matter and consumption》Requirement.This product is passed through Toxicological evaluation experiment, animal function test and human feeding trial are proved, are safely and effectively.
Invent it is a kind of it is new can safely and effectively play the hypoglycemia healthcare food of hypoglycemic effect, as health Market orientation, with reference to theory of traditional Chinese medical science, have developed and eaten using the health care of the wind-weed, the tuber of dwarf lilyturf, gynostemma pentaphylla, ginseng, chromium yeast as raw material Product, by supplementing qi and nourishing yin, the effect of promoting the production of body fluid to quench thirst, so as to reach auxiliary hyperglycemic, improves the purpose of user's quality of life.This Invention design is from having supplementing qi and nourishing yin, and the wind-weed, the tuber of dwarf lilyturf, gynostemma pentaphylla, ginseng, the chromium yeast of the effect that promotes the production of body fluid to quench thirst are raw material, are adopted Cost product is refined with modernization processing technology, middle the effective elements of the medicine had both been remained, and had reduced dose again, and from suction Receipts, stability etc. many-side consider select capsule formulation, while have be easy to carry about with one, it is convenient to take the features such as.Its property of medicine is gentle, Long-term taking safety, is favorably improved user's quality of life.
The content of the invention
It is an object of the present invention to provide absorption and the profit of a kind of safely and effectively auxiliary diabetic reduction blood glucose With, and adjust a series of health food of complication caused by improvement reduction hyperglycaemia.
The raw material for the health food that the present invention is provided includes：The wind-weed, the tuber of dwarf lilyturf, gynostemma pentaphylla, ginseng, chromium yeast.
The raw material weight ratio for the health food that the present invention is provided includes：100-600 parts of the wind-weed, tuber of dwarf lilyturf 100-600 part, strand Blue 100-600 parts, 50-200 parts of ginseng, 1-20 parts of chromium yeast.
It is corresponding in health food to include 100 parts of the wind-weed, 100 parts of the tuber of dwarf lilyturf, strand according to the raw material weight of the present invention than preferred Blue 100 parts, 50 parts of ginseng, 1 part of chromium yeast.
According to the raw material weight ratio of the present invention it is also preferred that correspondence includes 400 parts of the wind-weed, 350 parts of the tuber of dwarf lilyturf, strand in health food Stock is blue 350 parts, 180 parts of ginseng, 8 parts of chromium yeast.
According to the raw material weight ratio of the present invention it is also preferred that correspondence includes 550 parts of the wind-weed, 450 parts of the tuber of dwarf lilyturf, strand in health food Stock is blue 500 parts, 150 parts of ginseng, 16 parts of chromium yeast.
According to the raw material weight ratio of the present invention it is also preferred that correspondence includes 600 parts of the wind-weed, 600 parts of the tuber of dwarf lilyturf, strand in health food Stock is blue 600 parts, 200 parts of ginseng, 20 parts of chromium yeast.
The active component preparation method of health food of the present invention, is made up of following steps：
(1) ginseng is ground into fine powder and is used as medicine；Chromium yeast is directly used as medicine.
(2) wind-weed, the tuber of dwarf lilyturf, gynostemma pentaphylla are extracted with water, and filtration, filtrate is concentrated into clear cream.
(3) above-mentioned clear cream is dried under reduced pressure, crushed, mixed, pelletize with ginseng fine powder and chromium yeast, drying, whole grain, filling out Fill, polish, pack.
Capsule of the invention specific by following steps preparation
1. more than four traditional Chinese medicine material and chromium yeast after the assay was approved, used for preparation.
2. taking ginseng, dry (60 DEG C) and crush afterwards, cross 100 mesh sieves, formula ratio fine powder is collected, with 5kGy dosage60Co spokes It is standby after sterilizing.
3. the wind-weed, the tuber of dwarf lilyturf, gynostemma pentaphylla are added water to cook 2 times, 10 times of amount water, 2.0 hours every time, decocting liquid filtration are added every time (dregs of a decoction are abandoned), merging filtrate and be concentrated under reduced pressure (- 0.065--0.075Mpa, 75 DEG C) to relative density be 1.30~1.35 (60 DEG C) clear cream, in 65 DEG C decompression (- 0.085Mpa) dry, pulverize, cross 80 mesh sieves, it is standby.
4. being mixed again with dried cream powder after chromium yeast is mixed with ginseng fine powder, with 80% ethanol softwood, 16 mesh sieves are pelletized, 60 DEG C of dryings, 14 mesh sieve whole grains load No. 0 capsule, polish, and pack, and examine, get product.
Tablet, granule, effervescent agent can also be made in the health food that the present invention is provided in addition to capsule formulation according to technique And liquid preparation etc..
Embodiment
Following embodiments are used for the preparation for illustrating the present invention, but it can not constitute any limit to the scope of the present invention System.
Embodiment 1：
For the ease of the application of health food of the present invention, the health food is prepared into capsule：
Bulk drug is matched：Wind-weed 100g, tuber of dwarf lilyturf 100g, gynostemma pentaphylla 100g, ginseng 50g, chromium yeast 1g.
Preparation method：
(1) more than four traditional Chinese medicines material and chromium yeast after the assay was approved, are used for preparation.
(2) takes ginseng, dries (60 DEG C) and crushes afterwards, crosses 100 mesh sieves, formula ratio fine powder is collected, with 5kGy dosage60Co It is standby after irradiation sterilization.
(3) adds water to cook the wind-weed, the tuber of dwarf lilyturf, gynostemma pentaphylla 2 times, and 10 times of amount water, 2.0 hours every time, decocting liquid filtration are added every time (dregs of a decoction are abandoned), merging filtrate and be concentrated under reduced pressure (- 0.065--0.075Mpa, 75 DEG C) to relative density be 1.30~1.35 (60 DEG C) clear cream, in 65 DEG C decompression (- 0.085Mpa) dry, pulverize, cross 80 mesh sieves, it is standby.
(4) mixed again with dried cream powder after mixes chromium yeast with ginseng fine powder, with 80% ethanol softwood, 16 mesh sieve series Grain, 60 DEG C of dryings, 14 mesh sieve whole grains load No. 0 capsule, polish, and pack, and examine, get product.
Embodiment 2：
For the ease of the application of health food of the present invention, the health food is prepared into capsule：
Bulk drug is matched：Wind-weed 400g, tuber of dwarf lilyturf 350g, gynostemma pentaphylla 350g, ginseng 180g, chromium yeast 8g.
Preparation method：
(1) more than four traditional Chinese medicines material and chromium yeast after the assay was approved, are used for preparation.
(2) takes ginseng, dries (60 DEG C) and crushes afterwards, crosses 100 mesh sieves, formula ratio fine powder is collected, with 5kGy dosage60Co It is standby after irradiation sterilization.
(3) adds water to cook the wind-weed, the tuber of dwarf lilyturf, gynostemma pentaphylla 2 times, and 10 times of amount water, 2.0 hours every time, decocting liquid filtration are added every time (dregs of a decoction are abandoned), merging filtrate and be concentrated under reduced pressure (- 0.065--0.075Mpa, 75 DEG C) to relative density be 1.30~1.35 (60 DEG C) clear cream, in 65 DEG C decompression (- 0.085Mpa) dry, pulverize, cross 80 mesh sieves, it is standby.
(4) mixed again with dried cream powder after mixes chromium yeast with ginseng fine powder, with 80% ethanol softwood, 16 mesh sieve series Grain, 60 DEG C of dryings, 14 mesh sieve whole grains load No. 0 capsule, polish, and pack, and examine, get product.
Embodiment 3：
For the ease of the application of health food of the present invention, the health food is prepared into capsule：
Bulk drug is matched：Wind-weed 550g, tuber of dwarf lilyturf 450g, gynostemma pentaphylla 500g, ginseng 150g, chromium yeast 16g.
Preparation method：
(1) more than four traditional Chinese medicines material and chromium yeast after the assay was approved, are used for preparation.
(2) takes ginseng, dries (60 DEG C) and crushes afterwards, crosses 100 mesh sieves, formula ratio fine powder is collected, with 5kGy dosage60Co It is standby after irradiation sterilization.
(3) adds water to cook the wind-weed, the tuber of dwarf lilyturf, gynostemma pentaphylla 2 times, and 10 times of amount water, 2.0 hours every time, decocting liquid filtration are added every time (dregs of a decoction are abandoned), merging filtrate and be concentrated under reduced pressure (- 0.065--0.075Mpa, 75 DEG C) to relative density be 1.30~1.35 (60 DEG C) clear cream, in 65 DEG C decompression (- 0.085Mpa) dry, pulverize, cross 80 mesh sieves, it is standby.
(4) mixed again with dried cream powder after mixes chromium yeast with ginseng fine powder, with 80% ethanol softwood, 16 mesh sieve series Grain, 60 DEG C of dryings, 14 mesh sieve whole grains load No. 0 capsule, polish, and pack, and examine, get product.
Embodiment 4：
For the ease of the application of health food of the present invention, the health food is prepared into capsule：
Bulk drug is matched：Wind-weed 600g, tuber of dwarf lilyturf 600g, gynostemma pentaphylla 600g, ginseng 200g, chromium yeast 20g.
Preparation method：
(1) more than four traditional Chinese medicines material and chromium yeast after the assay was approved, are used for preparation.
(2) takes ginseng, dries (60 DEG C) and crushes afterwards, crosses 100 mesh sieves, formula ratio fine powder is collected, with 5kGy dosage60Co It is standby after irradiation sterilization.
(3) adds water to cook the wind-weed, the tuber of dwarf lilyturf, gynostemma pentaphylla 2 times, and 10 times of amount water, 2.0 hours every time, decocting liquid filtration are added every time (dregs of a decoction are abandoned), merging filtrate and be concentrated under reduced pressure (- 0.065--0.075Mpa, 75 DEG C) to relative density be 1.30~1.35 (60 DEG C) clear cream, in 65 DEG C decompression (- 0.085Mpa) dry, pulverize, cross 80 mesh sieves, it is standby.
(4) mixed again with dried cream powder after mixes chromium yeast with ginseng fine powder, with 80% ethanol softwood, 16 mesh sieve series Grain, 60 DEG C of dryings, 14 mesh sieve whole grains load No. 0 capsule, polish, and pack, and examine, get product.
Test example
There is the effect for the treatment of hypertension, the health food as obtained by embodiment method to illustrate health food of the present invention Medicine has carried out following experiment.
1st, the detection of Registration Test functional component, stability experiment, Hygienic determination are carried out through disease prevention and control center of province.
Experimental result meets design requirement, and meets the registration requirement of health food.
Examining report is numbered：Hubei Province disease control (2010) searching 07092f, Hubei Province disease control (2010) searching 07092e etc..
2nd, health food safety evaluatio
According to《Health food is examined and assessment technique specification》Version (the toxicology method of inspection) in 2003
Chmice acute experiment, Micronucleus test, mouse inbred strain and 30 days feeding trials
The SPF levels Kunming mouse of 2.1 pairs of two kinds of sexes carries out acute oral toxicity test, and accumulative given low twice reaches 20.0g/kgBW (equivalent to 500 times that crowd recommends daily intaking amount 0.04g/kgBW), animal has no within the observation period of 14 days Obvious poisoning symptom and death, according to acute toxicity grading evaluation criteria regulation, the given the test agent belongs to nontoxic level；
2.2 binomial mutagenicity tests (mouse marrow cell micro nuclear test and mouse inbred strain) result is the moon Property；
2.3.30 feeding trial result in day shows given the test agent (distinguishing phase by 1.00,2.00,4.00g/kg BW dosage When in 25.50.100 times of crowd's recommendation daily intaking amount 0.04g/kgBW) continuously give 30 days animals to SPF grades of Wistar rats Have no obvious poisoning symptom and death.Each dosage group rat body weight of given the test agent, food-intake, food utilization, hematology, blood Liquid biochemistry, organ weights, dirty/index such as body ratio and Histopathology are compared with negative control group, and there are no significant for difference, As a result it is not find that the given the test agent has obvious toxic action.
2.4Ames experiments to tetra- plants of test strains of salmonella typhimurium TA97, TA98, TAlOO, TA102, add with not Plus during S9,0.2,0.5,1.0,2.5,5.0mg/ wares 5 dosage groups return and become clump count not less than 2 times of negative control clump count, Also without the reaction relation of dosage one, Salmonella reversion test result is negative.
3rd, function of health food inspection
Detect foundation《Health food is examined and assessment technique specification》(Ministry of Public Health's version in 2003)
Test result
Using SPF grades of kunming mices, hyperglycemia model is set up using alloxan tail vein injection medication, set simultaneously Put normal mouse and give tested material group.The crowd day recommended intake that censorship unit is provided is 2.4g/60kg BW, i.e. 0.04g/ KgBW, with its 10.20.30 times set basic, normal, high three dosage be respectively 0.4,0.8,1.2g/kgBW, corresponding group mouse connects Continuous gavage carries out the test about index after 30 days, level of significance test is P<0.05, as a result show；
3.1.1, with 1.2g/kg BW SPF grades of dosage gavage Kunming kind normal mouse 30 days, to its body weight and fasting blood Sugar value is without influence；
3.1.2, each dosage group on hyperglycemia model mouse weight without influence；
3.1.3, middle and high dosage group animal fasting blood sugar is decreased obviously, and fasting blood-glucose rate of descent substantially rises, with high blood Sugared mould
Type control group compares, and difference has conspicuousness (P ＜ 0.05)
3.1.4, middle and high dosage group animal to give Oh, 0.5h, 2h blood glucose value and Area under the curve of blood glucose after glucose obvious Decline, compared with hyperglycemia model control group, difference has conspicuousness (P ＜ 0.05).
Judged according to result above, the product auxiliary hyperglycemic animal test results are positive.
4th, auxiliary hyperglycemic function crowd test-meal is tested
Test basis：The Ministry of Public Health《Health food is examined and assessment technique specification》(version in 2003)
Conclusion (of pressure testing)：
Meet (the control group 51 of hyperglycemia population 103 of the tested inclusion criteria of this experiment：Man 23, female 28；Test-meal Group 52；Man 30, female 22), after wherein test-meal group crowd continuously takes capsule 30 days, the fasting blood-glucose of test-meal group crowd and 2 hours blood glucose contents averagely have dropped 10.21% and 10.67% respectively after the meal, higher than-the 0.69% and -1.22% of control group, Group difference has conspicuousness (P ＜ 0.01).Compare before and after the fasting blood-glucose of test-meal group and after the meal 2 hours blood glucoses itself, difference is equal There is conspicuousness (P ＜ 0.01).It is 86.54%, the difference compared with the 39.22% of control group that test-meal group clinical symptoms, which improve efficiency, There is conspicuousness (P ＜ 0.01)；Test-meal group glucose in urine integral mean have dropped 0.48 point, and higher than punishment according to -0.01 point of group, difference has aobvious Work property (P ＜ 0.01).Sample to the T-CHOL of subject, cut oily three ester, HDL-C and have no significant effect.By The general symptom and sign of examination person, blood routine, conventional stool and urine, blood parameters and other clinical examinations are without exception, and items refer to Result is marked in range of normal value, in process of the test test-meal sample person not occur nausea, flatulence, diarrhoea and allergy etc. bad Reaction.As can be seen here, the sample has the function of auxiliary hyperglycemic, and harmless to tested population health.
In summary, the health food provided using the present invention is taken to diabetes patient, and effect is respectively provided with excellent drop blood Sugar effect, reduction improves the generation of complication, therefore it is auxiliary the health food that the present invention is provided to can be used to carry out diabetic Help treatment.
Brief description of the drawings
Fig. 1：The technique preparation flow figure of the present invention.

Claims (8)

1. a kind of health-care edible capsule preparation method with auxiliary hyperglycemic function, it is characterised in that the Ricipe for health care food It is made up of the wind-weed, the tuber of dwarf lilyturf, gynostemma pentaphylla, ginseng, chromium yeast.
2. health food according to claim 1, it is characterised in that the part by weight of the raw material of the health-care food is： 100-600 parts of the wind-weed, tuber of dwarf lilyturf 100-600 part, 100-600 parts of gynostemma pentaphylla, 50-200 parts of ginseng, 1-20 parts of chromium yeast.
3. health food according to claim 2, it is characterised in that the part by weight of the raw material of the health-care food is： 100 parts of the wind-weed, 100 parts of the tuber of dwarf lilyturf, 100 parts of gynostemma pentaphylla, 50 parts of ginseng, 1 part of chromium yeast.
4. health food according to claim 2, it is characterised in that the part by weight of the raw material of the health-care food is： 400 parts of the wind-weed, 350 parts of the tuber of dwarf lilyturf, 350 parts of gynostemma pentaphylla, 180 parts of ginseng, 8 parts of chromium yeast.
5. health food according to claim 2, it is characterised in that the part by weight of the raw material of the health-care food is： 550 parts of the wind-weed, 450 parts of the tuber of dwarf lilyturf, 500 parts of gynostemma pentaphylla, 150 parts of ginseng, 16 parts of chromium yeast.
6. health food according to claim 2, it is characterised in that the part by weight of the raw material of the health-care food is： 600 parts of the wind-weed, 600 parts of the tuber of dwarf lilyturf, 600 parts of gynostemma pentaphylla, 200 parts of ginseng, 20 parts of chromium yeast.
7. according to the active component preparation method of any described health foods of claim 2-6, it is characterised in that the activity The preparation method of composition is made up of following steps：
(1) more than four traditional Chinese medicines material and chromium yeast after the assay was approved, are used for preparation；
(2) takes ginseng, dries (60 DEG C) and crushes afterwards, crosses 100 mesh sieves, formula ratio fine powder is collected, with 5kGy dosage60Co is irradiated It is standby after sterilizing；
(3) adds water to cook the wind-weed, the tuber of dwarf lilyturf, gynostemma pentaphylla 2 times, and 10 times of amount water, 2.0 hours every time, decocting liquid filtration (medicine are added every time Slag is abandoned), merging filtrate and be concentrated under reduced pressure (- 0.065--0.075Mpa, 75 DEG C) to relative density for 1.30~1.35 (60 DEG C) Clear cream, dry, pulverize in 65 DEG C of decompressions (- 0.085Mpa), cross 80 mesh sieves, standby；
(4) mixed again with dried cream powder after mixes chromium yeast with ginseng fine powder, with 80% ethanol softwood, the granulation of 16 mesh sieves, 60 DEG C drying, 14 mesh sieve whole grains load No. 0 capsule, polish, and pack, and examine, get product.
8. according to the active component preparation method of any described health foods of claim 2-6, it is characterised in that the health care The preparation formulation of food can also develop tablet, pill, granule, oral liquid or health drink simultaneously.
CN201710606216.6A 2017-07-24 2017-07-24 A kind of health-care edible capsule preparation method with auxiliary hyperglycemic function Pending CN107260946A (en)

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109430721A (en) * 2018-10-17 2019-03-08 广州市好孝心医疗器械有限公司 A kind of wheat embryo composition and preparation method thereof with hypoglycemic effect
CN111437353A (en) * 2019-01-17 2020-07-24 四川通世达生物科技有限公司 Medicinal and edible plant composition for assisting in reducing blood sugar and application thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
58会销网: "青晨药业厂家诚招全国会销代理、会销OEM贴牌、会销大包商", 《WWW.58HUIXIAO.COM/ZX/SHOW-1141.HTM》 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109430721A (en) * 2018-10-17 2019-03-08 广州市好孝心医疗器械有限公司 A kind of wheat embryo composition and preparation method thereof with hypoglycemic effect
CN111437353A (en) * 2019-01-17 2020-07-24 四川通世达生物科技有限公司 Medicinal and edible plant composition for assisting in reducing blood sugar and application thereof

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