CN104435141A - Traditional Chinese medicine composition containing winged euonymus twig and used for treating diabetes - Google Patents
Traditional Chinese medicine composition containing winged euonymus twig and used for treating diabetes Download PDFInfo
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- CN104435141A CN104435141A CN201410637281.1A CN201410637281A CN104435141A CN 104435141 A CN104435141 A CN 104435141A CN 201410637281 A CN201410637281 A CN 201410637281A CN 104435141 A CN104435141 A CN 104435141A
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- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention belongs to the technical field of medicine, relates to a traditional Chinese medicine composition and particularly relates to a traditional Chinese medicine composition containing winged euonymus twig and used for treating diabetes. The traditional Chinese medicine composition used for treating diabetes is prepared from the following medical raw materials in parts by weight: 7-25 parts of astragalus membranaceus, 6-20 parts of tartary buckwheat stems, 3-10 parts of aralia mandshrica, 3-10 parts of honeysuckle stem, 3-10 parts of mulberry, 1-5 parts of winged euonymus twig and 1-5 parts of licorice. According to the traditional Chinese medicine composition used for treating diabetes provided by the invention, 7 medical raw materials are combined according to a formula proportion to entitle a synergistic interaction function for treating diabetes, and the curative effect for treating diabetes is significant without generating side effects on the body of a patient.
Description
Technical field
The invention belongs to medical art, relate to a kind of Chinese medicine composition, be specifically related to a kind of Chinese medicine composition of the treatment diabetes containing Ramulus Euonymi.
Background technology
The metabolic disease of diabetes to be one group with hyperglycemia be feature, is that China's sickness rate is high, endangers one of serious epidemic diseases.Long-standing hyperglycemia during diabetes, causes various tissue, particularly eye, kidney, heart, blood vessel, neural chronic lesion, dysfunction, causes various diabetic complication.According to statistics, the mortality rate of diabetic complication is only second to cardiovascular diseases, cerebrovascular and tumor, occupies the 4th.Diabetes mellitus in China patient populations close to 4,000 ten thousand people, occupies third place in the world, compared with 0.7% of the eighties in 20th century, increases 5 times.Diabetes can be caused by h and E factor interaction, and common sympton has polydipsia, polyuria, polyphagia and becomes thin.Diabetes can cause the infringement of health multisystem; Absolute or the relative hyposecretion of insulin and target tissue cell is caused to reduce insulin sensitivity; Causing a series of metabolism disorder syndromes such as protein, fat, water and eletrolytes, is wherein outstanding feature with hyperglycemia.The medicine of current treatment diabetes is a lot, especially Western medicine, but side effect is large, and Chinese patent medicine effect is remarkable not.
Summary of the invention
Object of the present invention provides a kind of Chinese medicine composition of the treatment diabetes containing Ramulus Euonymi, this Chinese medicine composition good effect, little to person side effect.
In order to realize foregoing invention object, the invention provides following technical scheme:
Containing a Chinese medicine composition for the treatment diabetes of Ramulus Euonymi, be prepared from by the medicinal raw material of following weight proportion: the Radix Astragali 7 ~ 25 parts, 6 ~ 20 parts, Radix Et Rhizoma Fagopyri Tatarici stem, Aralia mandshurica 3 ~ 10 parts, Caulis Lonicerae 3 ~ 10 parts, Fructus Mori 3 ~ 10 parts, Ramulus Euonymi 1 ~ 5 part, 1 ~ 5 part, Radix Glycyrrhizae.Described various medicinal raw material is the Chinese crude drug meeting country or provincial standard and specify.
Preferably, in above-mentioned medicinal raw material, part by weight shared by the Radix Astragali is 12 ~ 18 parts.Preferred, part by weight shared by the Radix Astragali is 15 parts.
Preferably, in above-mentioned medicinal raw material, part by weight shared by Radix Et Rhizoma Fagopyri Tatarici stem is 9 ~ 15 parts.Preferred, part by weight shared by Radix Et Rhizoma Fagopyri Tatarici stem is 12 parts.
Preferably, in above-mentioned medicinal raw material, part by weight shared by Aralia mandshurica is 5 ~ 7 parts.Preferred, part by weight shared by Aralia mandshurica is 6 parts.
Preferably, in above-mentioned medicinal raw material, part by weight shared by Caulis Lonicerae is 5 ~ 7 parts.Preferred, part by weight shared by Caulis Lonicerae is 6 parts.
Preferably, in above-mentioned medicinal raw material, part by weight shared by Fructus Mori is 5 ~ 7 parts.Preferred, part by weight shared by Fructus Mori is 6 parts.
Preferably, in above-mentioned medicinal raw material, part by weight shared by Ramulus Euonymi is 2 ~ 4 parts.Preferred, part by weight shared by Ramulus Euonymi is 3 parts.
Preferably, in above-mentioned medicinal raw material, part by weight shared by Radix Glycyrrhizae is 2 ~ 4 parts.Preferred, part by weight shared by Radix Glycyrrhizae is 3 parts.
The Chinese medicine composition for the treatment of diabetes of the present invention, Traditional Chinese medicine extraction method conveniently can extract the active component of medicinal raw material, as decocted with water, or collects extracting solution and concentrated by the aqueous solution reflux, extract, of ethanol or ethanol; Add pharmaceutically acceptable carrier or/and adjuvant, as starch, dextrin, microcrystalline cellulose, amylum pregelatinisatum, magnesium stearate, micropowder silica gel, sucrose, carboxymethyl starch sodium, hydroxypropyl emthylcellulose, vegetable oil, lecithin, Polyethylene Glycol, propylene glycol, ethyl hydroxybenzoate etc., make dosage form suitable on pharmaceutics, as granule, tablet, hard capsule, oral liquid, soft capsule, drop pill, water pill etc.
Compared with prior art, beneficial effect of the present invention:
The present invention treats the Chinese medicine composition of diabetes, that inventor is based on the pathogenetic understanding of motherland's medical science to diabetes, according to oneself clinical experience for many years, first determine a series of to the effective Chinese medicine for the treatment of diabetes from numerous Chinese medicine, then screen through clinical repeatedly checking.Wherein, the Radix Astragali, the sweet temperature rise of the Radix Astragali is mended, and enters spleen, lung meridian; Main with righting gas, hold concurrently and can remove pathogenic water; Both be apt to invigorating middle warmer gas, elevate a turnable ladder is positive clearly, kind tonifying the lung gas, benefiting QI for strengthening the superficies, can also hold in the palm sore, inducing diuresis to remove edema again.Radix Et Rhizoma Fagopyri Tatarici stem, sweet-bitter flavor, property is put down, and returns spleen, stomach, large intestine channel; Have that spleen invigorating row is stagnant, effect of regulating QI to relieve pain, removing toxic substances and promoting subsidence of swelling; For diseases such as epigastric distending pain, dyspepsia, dysentery, lumbago and skelalgia, traumatic injury, carbuncle malignant boil.Aralia mandshurica, another name Cortex Araliae Elatae Radicis, tiger sun thorn, thorn fossilia dentis mastodi; For Wu Jia Ke Cortex araliae chinensis platymiscium Liao Dong Cortex araliae chinensis, be used as medicine with root bark; Sweet in the mouth, hardship, property is put down; There is the effects such as stomach invigorating, diuretic, expelling wind and removing dampness, promoting blood circulation and stopping pain; For taste-blindness rate, chronic gastritis, hepatitis, diabetes, rheumatic arthritis, the diseases such as edema.Caulis Lonicerae, another name Radix Ophiopogonis, Caulis Lonicerae, Caulis Lonicerae; For the dry stem branch of caprifoliaceae plant Radix Ophiopogonis; Sweet, cold; Attach to the lung and stomach meridians; There is effect of heat-clearing and toxic substances removing, dispelling wind dredging collateral; For epidemic febrile disease heating, toxic-heat and blood stasis, carbuncle skin infection, beriberoid pyretic arthralgia, the diseases such as redness and swelling of joints burning pain.Fructus Mori, have another name called Fructus Mori, are the dry fruit ear of moraceae plants Mulberry.Sweet, sour, cold; GUIXIN, liver, kidney channel; There is YIN nourishing of enriching blood, effect of moisturizing of promoting the production of body fluid; For vertigo and tinnitus, palpitation and insomnia, early whitening of beard and hair, Tianjin wound is thirsty, the diseases such as interior-heat is quenched one's thirst, blood deficiency and constipation.Ramulus Euonymi, another name winged euonymus, terrible arrow (" herbal classic "), refreshing arrow (" extensively refined "), air pressure gun woods (" will planted by middle traditional Chinese medicines "), Gallus jabouillei strip (" will planted by northeast medicine "), four sides halberd (" pharmacognosy ") etc.; For branch or the aliform appurtenance of the tool fin of Celastraceae plant winged euonymus; Hardship, cold; " enter meridian of Foot-JUE YIN." there is removing blood stasis, stimulate the menstrual flow, effect of parasite killing; For controlling amenorrhea, lump in the abdomen, the stagnant stomachache of the stasis of blood in puerperal, abdominal pain due to worm stagnation etc.Radix Glycyrrhizae, sweet in the mouth is put down; GUIXIN, lung, spleen, stomach warp.There is invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, effect of coordinating the actions of various ingredients in a prescription.For weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.After above-mentioned 7 taste Chinese herbal medicine press formula proportion mixing, Traditional Chinese medicine extraction method conveniently obtains the Chinese medicine composition for the treatment of diabetes of the present invention after extracting the active component of medicinal raw material.After formula proportion combination pressed by 7 taste medicines wherein, treatment diabetes have the function of Synergistic, can significantly reduce blood glucose, serum lipid concentrations, improve blood flow and anti-oxidation efficacy, treat diabetes Be very effective and have no side effect.
Detailed description of the invention
Below in conjunction with test example and detailed description of the invention, the present invention is described in further detail.But this should be interpreted as that the scope of the above-mentioned theme of the present invention is only limitted to following embodiment, all technology realized based on content of the present invention all belong to scope of the present invention.
Embodiment 1
The Chinese medicine composition of the treatment diabetes of the present embodiment is prepared from by the medicinal raw material of following weight proportion: Radix Astragali 15g, Radix Et Rhizoma Fagopyri Tatarici stem 12g, Aralia mandshurica 6g, Caulis Lonicerae 6g, Fructus Mori 6g, Ramulus Euonymi 3g, Radix Glycyrrhizae 3g.
The extracting method of above-mentioned medicinal raw material: get medicinal raw material by formula proportion, 2 times are decocted with water in medicinal raw material, be followed successively by medicinal raw material volume by water volume 10 times and 8 times that decoct for 2 times, 2 times decocting time is followed successively by 1.5 hours and 1 hour, filters and collects filtrate after each decoction; Merge 2 filtrates, obtain the extracting solution of embodiment 1 medicinal raw material, the extracting solution of embodiment 1 medicinal raw material is concentrated into relative density 1.20 (80 DEG C), obtains the extract of embodiment 1.
In above-mentioned extract, add the soluble starch of extract 2 times of weight, granulation, drying, be distributed into bag, obtain the Chinese medicinal composition granules that embodiment 1 treats diabetes.
Embodiment 2
The Chinese medicine composition of the treatment diabetes of the present embodiment is prepared from by the medicinal raw material of following weight proportion: Radix Astragali 25g, Radix Et Rhizoma Fagopyri Tatarici stem 6g, Aralia mandshurica 10g, Caulis Lonicerae 3g, Fructus Mori 3g, Ramulus Euonymi 5g, Radix Glycyrrhizae 3g.
The extracting method of above-mentioned medicinal raw material is with embodiment 1.
Embodiment 3
The Chinese medicine composition of the treatment diabetes of the present embodiment is prepared from by the medicinal raw material of following weight proportion: Radix Astragali 18g, Radix Et Rhizoma Fagopyri Tatarici stem 13g, Aralia mandshurica 7g, Caulis Lonicerae 8g, Fructus Mori 5g, Ramulus Euonymi 2g, Radix Glycyrrhizae 2g.
The extracting method of above-mentioned medicinal raw material is with embodiment 1.
Comparative example
The Chinese medicine composition of the treatment diabetes of the present embodiment is prepared from by the medicinal raw material of following weight proportion: Radix Astragali 15g, Radix Et Rhizoma Fagopyri Tatarici stem 12g, Aralia mandshurica 6g, Caulis Lonicerae 6g, Fructus Mori 6g, Radix Glycyrrhizae 3g.
The extracting method of above-mentioned medicinal raw material is with embodiment 1.
Pharmacodynamics test proves:
In order to the efficacy and saferry of proved invention medicine, inventors performed pharmacodynamics and toxicity test investigation.The research method adopted and result of the test as follows:
1, test material
(1) medicine and reagent:
According to Chinese medicine composition of the present invention prepared by embodiment 1;
According to comparative example Chinese medicine composition prepared by comparative example;
Alloxan, SIGMA Co. produces;
Glucose estimation kit, is produced by Beijing Chemical Plant;
Insoral, commercially available.
(2) animal: Kunming mouse, is provided by Sichuan institute of antibiotics Experimental Animal Center.
(3) instrument: VZS-723 spectrophotometer, electronic balance etc.
2, test method and result:
(1) medicine of the present invention is on the impact of alloxan diabetes mice hyperglycemia
(1) hyperglycemia model and grouping, is made
Get body weight 25 ± 1g Male Kunming strain mice 80, water is can't help in fasting.After 3 hours, tail vein injection alloxan normal saline solution 85mg/kg (0.5ml/ only) causes hyperglycemia model, separately by 15 body weight 25 ± 1g Male Kunming strain mice tail vein injection normal saline (0.5ml/ only), as Normal control animals.After 72 hours, above-mentioned mice fasting be can't help water 10 hours; Then get blood from its eye socket, glucose oxidase method surveys every mouse blood sugar concentration.
From the mice of 80 injection alloxan normal saline solutions, select blood glucose higher than 200mg/dL and close 60 of blood glucose value, be divided into 4 groups at random, i.e. model group, medicine group of the present invention, matched group 1 and insoral group, often organize 15.
(2), administration, survey blood sugar concentration
Five groups of mice difference gastric infusion and normal saline as follows: to the Chinese medicine composition of the medicine group gavage embodiment of the present invention 1 preparation of the present invention, medication accumulated dose: 7g/kg (raw medicinal herbs); To insoral group gavage insoral, medication accumulated dose: 80mg/kg; To Chinese medicine composition prepared by matched group 1 gavage comparative example of the present invention, medication accumulated dose: 7g/kg (raw medicinal herbs); To the normal saline of the solvent amounts such as model group gavages; The normal saline of the solvent amounts such as normal saline group gavages.
Successive administration 10 days, during administration and the ingesting of the mice respectively organized of fore-and-aft observing, movable and excretion situation situation all without exception occur.In administration in the 10th day after 1 hour, eye socket gets blood, surveys fasting plasma glucose concentration (fasting can't help water 10 hours, and method is with aforementioned).Between comparative control group 1 and model group, difference between each administration group, the results are shown in Table 1.
Table 1
Note: in table 1, compares with model group:
▲ ▲ ▲p < 0.001,
▲ ▲p < 0.05,
▲p > 0.05.
In table 1, experimental result shows: mouse mainline alloxan is after 72 hours, and mice hyperglycemia modeling success, its blood sugar concentration is significantly higher than normal saline group.With medicine group successive administration of the present invention after 10 days, mouse blood sugar concentration reduces to 385.2 ± 33.1mg/dL, about 61mg/dL lower than the mouse blood sugar concentration 446.4 ± 42.3mg/dL of model group.And the statistical result of medicine group of the present invention relative to model group statistical result P < 0.05, have significant difference, the blood sugar lowering therapeutic effect of medicine group of the present invention to alloxan diabetes mice hyperglycemia is good; And during mice administration and front and back have no adverse reaction, the traditional Chinese medicine composition for treating diabetes for the treatment of diabetes of the present invention are little to patient body side effect.
And matched group 1 successive administration is after 10 days, mouse blood sugar concentration is 424.3 ± 95.3mg/dL, about 22mg/dL lower than the mouse blood sugar concentration 446.4 ± 42.3mg/dL of model group; Than statistical value 385.2 ± 33.1mg/dL height about 39mg/dL of medicine group mouse blood sugar concentration of the present invention; And the statistical result of matched group 1 is relative to the statistical result P > 0.05 of model group, there was no significant difference.Therefore learn, the blood sugar lowering therapeutic effect of Chinese medicine composition to alloxan diabetes mice hyperglycemia prepared by comparative example is poor.
To sum up, the present invention treats the Chinese medicine composition of diabetes, good, the instant effect for the treatment of diabetes curative effect and having no side effect to health, and 7 taste medicinal raw materials press after formula proportion combines, and have Synergistic function; Lack any component, the curative effect of traditional Chinese medicine composition for treating diabetes all can obviously reduce, as in above-mentioned pharmacodynamics test, the therapeutic effect of matched group 1 obviously reduces relative to the curative effect of medicine group of the present invention, and the traditional Chinese medicine composition for treating diabetes for the treatment of diabetes of the present invention are little to patient body side effect.
Claims (10)
1., containing a Chinese medicine composition for the treatment diabetes of Ramulus Euonymi, it is characterized in that: it is made up of the medicinal raw material of following weight proportion: the Radix Astragali 7 ~ 25 parts, 6 ~ 20 parts, Radix Et Rhizoma Fagopyri Tatarici stem, Aralia mandshurica 3 ~ 10 parts, Caulis Lonicerae 3 ~ 10 parts, Fructus Mori 3 ~ 10 parts, Ramulus Euonymi 1 ~ 5 part, 1 ~ 5 part, Radix Glycyrrhizae.
2. Chinese medicine composition according to claim 1, is characterized in that: part by weight shared by the Radix Astragali is 12 ~ 18 parts.
3. the Chinese medicine composition for the treatment of diabetes according to claim 1, is characterized in that: part by weight shared by Radix Et Rhizoma Fagopyri Tatarici stem is 9 ~ 15 parts.
4. the Chinese medicine composition for the treatment of diabetes according to claim 1, is characterized in that part by weight shared by: Aralia mandshurica is 5 ~ 7 parts.
5. the Chinese medicine composition for the treatment of diabetes according to claim 4, is characterized in that part by weight shared by: Aralia mandshurica is 6 parts.
6. the Chinese medicine composition for the treatment of diabetes according to claim 1, is characterized in that: part by weight shared by Caulis Lonicerae is 5 ~ 7 parts.
7. the Chinese medicine composition for the treatment of diabetes according to claim 1, is characterized in that: part by weight shared by Fructus Mori is 5 ~ 7 parts.
8. the Chinese medicine composition for the treatment of diabetes according to claim 1, is characterized in that: part by weight shared by Ramulus Euonymi is 2 ~ 4 parts.
9. the Chinese medicine composition for the treatment of diabetes according to claim 8, is characterized in that: part by weight shared by Ramulus Euonymi is 3 parts.
10. the Chinese medicine composition for the treatment of diabetes according to claim 1, is characterized in that: part by weight shared by Radix Glycyrrhizae is 2 ~ 4 parts.
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