CN1403147A - Medicines composition for raising body's immunity and its prepn - Google Patents

Medicines composition for raising body's immunity and its prepn Download PDF

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Publication number
CN1403147A
CN1403147A CN02146571A CN02146571A CN1403147A CN 1403147 A CN1403147 A CN 1403147A CN 02146571 A CN02146571 A CN 02146571A CN 02146571 A CN02146571 A CN 02146571A CN 1403147 A CN1403147 A CN 1403147A
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parts
radix
rhizoma
stir
fry
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CN02146571A
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CN1188158C (en
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吴以岭
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河北以岭医药研究院有限公司
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Abstract

The present invention provides one medicine composition for raising body's immunity and invigorating spleen and kidney based on the Chinese medicine theory of strengthening body's resistance to eliminate evil. The medicine composition has 15 kinds of Chinese medicinal materials including astragalus root, privet seed, ginseng, glossy ganoderma, gynostemma pentaphylla, etc. The pharmacological test shows that the composite medicine capsule has obvious effects of inhibiting the growth of mouse's S180 sarcoma, prolonging the survival days of the mouse and raising the inhibition of chemotherapeutic medicine cyclophosphamide to mouse's S180 sarcoma.

Description

A kind of pharmaceutical composition of human body immunity improving function and preparation method
Technical field
The present invention relates to a kind of pharmaceutical composition of human body immunity improving function, belong to the Chinese herbal and crude drugs preparations technical field, be particularly useful for treating clinically deficiency of spleen and stomach such as tumor, hepatitis, liver cirrhosis, diseases such as emaciated physique, fatigue and asthenia, distension and fullness in the abdomen due to the combined symptoms in the stasis of blood poison.
Background technology
" deficient " category of diseases genus motherland medical science such as emaciated physique, fatigue and asthenia, distension and fullness in the abdomen due to the combined symptoms in the deficiency of spleen and stomach such as tumor, hepatitis, liver cirrhosis, stasis of blood poison.At present, the Chinese medicine preparation of treatment immunocompromised, as Radix codonopsis pilosulae's soft extract (invigorating the spleen and replenishing QI, the spleen invigorating lung benefiting), Polysaccharide-peptide capsule (nourishing the essence and strengthening QI, invigorating spleen and nourishing heart), ten flavor body-strengthening granules (benefiting vital QI and blood, warming YANG and strengthening the spleen), SHENQI FUZHENG ZHUSHEYE (QI invigorating is set upright), ginseng one capsule (element culturing fixed folder, benefiting vital QI and blood), they are partial to mend more, and are too unilateral.It is considered herein that diseases such as emaciated physique that immunocompromised disease occurs, fatigue and asthenia, spiritlessness and sparing of words, poor appetite lack of appetite, distension and fullness in the abdomen are deficiency of spleen and stomach, tie in the stasis of blood poison and cause, card for deficiency in origin and excess in superficiality, so with strengthening spleen, tonifying kidney, dissolving blood stasis and detoxication is the rule of treatment, starts with from treating both the principal and secondary aspects of a disease, can obviously improve body fluid and cellular immunization function, thereby enhancing resistance against diseases, but and physical strength reinforcing.
Summary of the invention
The present invention provides a kind of with the human body immunity improving function with traditional Chinese medical science strengthening vital QI to eliminate pathogenic factors theory, and the pharmaceutical composition of strengthening spleen, tonifying kidney reaches treating both the principal and secondary aspects of a disease.
Technical scheme of the present invention is achieved in that the pharmaceutical composition of this human body immunity improving function, and its proportion of composing (w/w) comprises Radix Astragali 130-390 part, Fructus Ligustri Lucidi 105-315 part, Radix Ginseng 39-117 part, Ganoderma 40-120 part, Rhizoma Curcumae 79-327 part, Herb Gynostemmae Pentaphylli 157-473 part, the Rhizoma Atractylodis Macrocephalae (stir-fry) 40-120 part, Poria 40-120 part, Cordyceps 5-15 part, Radix Cynanchi Paniculati 79-237 part, Eupolyphaga Seu Steleophaga 40-120 part, Radix Notoginseng 13-39 part, Herba Hedyotidis Diffusae 79-237 part, Herba Scutellariae Barbatae 79-237 part, Massa Medicata Fermentata (stir-fry) 25-75 part.
The pharmaceutical composition of described human body immunity improving function, its proportion of composing (w/w) comprise 260 parts of the Radixs Astragali, 210 parts of Fructus Ligustri Lucidi, 78 parts of Radix Ginsengs, 80 parts of Ganodermas, 158 parts of Rhizoma Curcumae, 315 parts of Herb Gynostemmae Pentaphylli, 80 parts of the Rhizoma Atractylodis Macrocephalaes (stir-fry), 80 parts in Poria, 10 parts of Cordyceps, 158 parts of Radix Cynanchi Paniculatis, 80 parts of Eupolyphaga Seu Steleophagas, 26 parts of Radix Notoginseng, 158 parts of Herba Hedyotidis Diffusaes, 158 parts of Herba Scutellariae Barbataes, 50 parts of Massa Medicata Fermentata (stir-fry).
The pharmaceutical composition of described human body immunity improving function, its form also can comprise Radix Codonopsis, Colla Plastri Testudinis, Fructus Psoraleae, rhizoma sparganic, Radix Ophiopogonis, Fructus Lycii, Radix Angelicae Sinensis, Radix Polygoni Multiflori, Radix Rehmanniae Preparata, Rhizoma Zingiberis, Semen Persicae, Radix Rehmanniae, the Rhizoma Anemarrhenae, Fructus Crataegi, Fructus Hordei Germinatus, the Cortex Eucommiae wherein one or more.
The preparation of drug combination method of above-mentioned human body immunity improving function comprises:
(1), 78 parts of Radix Ginsengs, 10 parts of Cordyceps, 26 parts of pulverize separately of Radix Notoginseng become fine powder, sieving for standby;
(2), 260 parts of the Radixs Astragali, 210 parts of Fructus Ligustri Lucidi, 80 parts of Ganodermas, 158 parts of Rhizoma Curcumae, 315 parts of Herb Gynostemmae Pentaphylli, 80 parts of the Rhizoma Atractylodis Macrocephalaes (stir-fry), 80 parts in Poria, promptly 158 parts of Xu's length, 80 parts of Eupolyphaga Seu Steleophagas, 158 parts of Herba Hedyotidis Diffusaes, 158 parts of Herba Scutellariae Barbataes, Massa Medicata Fermentata (stir-fry) decoct with water twice for 50 parts, 2 hours for the first time, 1 hour for the second time, merge decoction liquor and filter, filtrate concentrates, drying, be ground into fine powder, with step (1) powder facing-up, the mixing that sieves, encapsulated.
The pharmaceutical composition of above-mentioned human body immunity improving function can also be used for preparing clinically the base stock of oral formulations such as tablet, electuary, powder.
Pharmacological testing studies show that through the college of traditional Chinese medicine of Hebei Medical University, and medicament composition capsule of the present invention (trade name is for the strange capsule of China or join clever blue capsule) is to mice S 180The growth of sarcoma has obvious inhibitory action, can prolong ehrlich ascites tumor mice existence natural law, share mice S with the chemotherapeutics cyclophosphamide 180The inhibitory action of sarcoma has the notable synergistic effect, the mice serum hemolysin of caused by cyclophosphamide immunologic hypofunction is obviously raise, the splenocyte conversion ratio obviously increases, cyclophosphamide is caused the murine interleukin minimizing reverse effect, and cyclophosphamide is caused the minimizing of mice food-intake the increase effect.
Acute toxicity test in mice shows that the clinical consumption of capsule of the present invention is 6g/ day, and the oral maximum tolerated dose of mice is 20.0g/kg, 232.6 times of the clinical consumption that is equivalent to be grown up, animal Non Apparent Abnormality and death.Long term toxicity test shows: the present invention does not all have obvious influence to biochemical indicator such as the general situation of rat, body weight, hemogram and main organs coefficient, illustrates that the present invention does not have the overt toxicity reaction.See Appendix.
The specific embodiment
Example below in conjunction with drug regimen of the present invention illustrates the specific embodiment of the present invention.
Embodiment 1: the Radix Astragali 260g Fructus Ligustri Lucidi 210g Radix Ginseng 78g Ganoderma 80g Rhizoma Curcumae 158g Herb Gynostemmae Pentaphylli 315g Rhizoma Atractylodis Macrocephalae (stir-fry) 80g Poria 80g Cordyceps 10g Radix Cynanchi Paniculati 158g Eupolyphaga Seu Steleophaga 80g Radix Notoginseng 26g Herba Hedyotidis Diffusae 158g Herba Scutellariae Barbatae 158g Massa Medicata Fermentata (stir-fry) 50g preparation method:
(1), Radix Ginseng, Cordyceps, Radix Notoginseng pulverize separately become fine powder, sieving for standby;
(2), all the other medicines decoct with water twice, 2 hours for the first time, 1 hour for the second time, merge decoction liquor and filter, filtrate concentrates, drying is ground into fine powder, and is with step (1) powder facing-up, the mixing that sieves, encapsulated.
Embodiment 2: the Radix Astragali 150g fruit of glossy privet 100g ginseng 40g glossy ganoderma 80g curcuma zedoary 80g gynostemma pentaphylla 150g bighead atractylodes rhizome (stir-fry) 160g Poria cocos 80g Cordyceps sinensis 10g paniculate swallowwort 158g ground bettle 40g pseudo-ginseng 15g oldenlandia diffusa 158g Sculellaria barbata 80g hawthorn (stir-fry) 50g embodiment 3: the Radix Astragali 500g fruit of glossy privet 400g ginseng 150g glossy ganoderma 80g curcuma zedoary 320g gynostemma pentaphylla 600g bighead atractylodes rhizome (stir-fry) 40g Poria cocos 80g Cordyceps sinensis 10g paniculate swallowwort 158g ground bettle 160g pseudo-ginseng 50g oldenlandia diffusa 158g Sculellaria barbata 300g Fructus Hordei Germinatus (stir-fry) 50g
Embodiment 4: the Radix Astragali 500g Rhizoma Atractylodis Macrocephalae (stir-fry) 160g Radix Ginseng 150g Poria 160g rhizoma sparganic 320g Herb Gynostemmae Pentaphylli 600g Herba Hedyotidis Diffusae 300g Herba Scutellariae Barbatae 300g Rhizoma Dioscoreae 250g Arillus Longan 150g Fructus Lycii 150g Radix Polygoni Multiflori Preparata 86g Caulis Spatholobi 89g Radix Glycyrrhizae 90g
Embodiment 5: each 120 rhizoma sparganic 320g Herb Gynostemmae Pentaphylli 600g Herba Hedyotidis Diffusae 300g Herba Scutellariae Barbatae 300g Fructus Ligustri Lucidi 210g 160g Radix Ophiopogonis Fructus Lycii 150g Radix Angelicae Sinensis 89g Colla Plastri Testudinis 86g Fructus Crataegi 100g of the red Radix Paeoniae Alba of the Radix Astragali 500g Rhizoma Atractylodis Macrocephalae (stir-fry) 160g Radix Ginseng 150g
Embodiment 6: Radix Astragali 450g 220g Radix Ophiopogonis Radix Scrophulariae 120g Rhizoma dioscoreae 89g Fructus Lycii 90g Rhizoma Anemarrhenae 67g Rhizoma Polygonati Odorati 68g Herb Gynostemmae Pentaphylli 600g Herba Hedyotidis Diffusae 300g Herba Scutellariae Barbatae 300g Fructus Schisandrae Chinensis 45g Radix Trichosanthis 68
Embodiment 7: Radix Astragali 450g Radix Ginseng 150g Radix Aconiti Lateralis Preparata 45g Herba Epimedii 68g Rhizoma Curculiginis 35g Fructus Psoraleae 89g Cordyceps 10g Cortex Eucommiae 86g Herba Hedyotidis Diffusae 300g Herba Scutellariae Barbatae 300g 150g Radix Ophiopogonis Radix Rehmanniae 150g Radix Glycyrrhizae 90g
Embodiment 8: Radix Codonopsis 220g Radix Astragali 250g Rhizoma Atractylodis Macrocephalae 180g Rhizoma dioscoreae 98g stir-fried kidney beans 120g Poria 150g Rhizoma Curcumae 158g Herb Gynostemmae Pentaphylli 315g Herba Scutellariae Barbatae 158g gives birth to Semen Coicis 86g Pericarpium Citri Reticulatae 68g Radix Glycyrrhizae 90g
Embodiment 9: Radix Codonopsis 450g Radix Astragali 250g Rhizoma Atractylodis Macrocephalae 120g Rhizoma dioscoreae 68g Poria 76g Rhizoma Alismatis 35g Cortex Cinnamomi 86g Semen Cuscutae 120g Fructus Ligustri Lucidi 210g Fructus Corni 86g Radix Rehmanniae 86g Fructus Psoraleae 98g Fructus Lycii 68g Pericarpium Citri Reticulatae 98g Radix Cyathulae 68
Embodiment 10: the Radix Astragali (processing) 450g Rhizoma Atractylodis Macrocephalae 220g Fructus Ligustri Lucidi 210g Poria 80g Herba Scutellariae Barbatae 158g Rhizoma Curcumae 158g Cortex Magnoliae Officinalis 65g Fructus Aurantii Immaturus 56g Pericarpium Citri Reticulatae 98g Fructus Lycii 86g FLOS MUME 50g Radix Ginseng 45g Massa Medicata Fermentata (stir-fry) 45g Radix Glycyrrhizae 90gg
Embodiment 11: each 86g rhizoma sparganic 180g Eupolyphaga Seu Steleophaga 80g Radix Notoginseng 26g Radix Polygoni Multiflori Preparata 86g Radix Salviae Miltiorrhizae 110g Poria 86g Rhizoma Dioscoreae 86g Radix Cyathulae 120g Flos Carthami 86g Radix Glycyrrhizae 90g of the red Radix Paeoniae Alba of Radix Astragali 450g Rhizoma Atractylodis Macrocephalae 220g Radix Angelicae Sinensis 35g Radix Rehmanniae Preparata 150g
The preparation method of embodiment 2-11 and embodiment 1 are basic identical.
The mixture that the preparation method of the foregoing description is made can be used for preparing clinically the base stock of oral formulations such as tablet, electuary, powder.
Pharmaceutical composition of the present invention is monarch with the Radix Astragali, Fructus Ligustri Lucidi, with Radix Ginseng, Ganoderma, Rhizoma Curcumae, Herb Gynostemmae Pentaphylli is ministerial drug, the Rhizoma Atractylodis Macrocephalae, Poria, Cordyceps, Radix Cynanchi Paniculati, Eupolyphaga Seu Steleophaga, Radix Notoginseng, Herba Hedyotidis Diffusae are adjuvant drug altogether, Herba Scutellariae Barbatae, Massa Medicata Fermentata are for making, the tumor that causes for immunologic hypofunction, hepatitis, liver cirrhosis etc. all can be used as the treatment ancillary drug and use, but physical strength reinforcing is resisted exopathogen, makes the body early recovery.

Claims (4)

1, a kind of pharmaceutical composition of human body immunity improving function, its proportion of composing (w/w) comprise Radix Astragali 130-390 part, Fructus Ligustri Lucidi 105-315 part, Radix Ginseng 39-117 part, Ganoderma 40-120 part, Rhizoma Curcumae 79-327 part, Herb Gynostemmae Pentaphylli 157-473 part, the Rhizoma Atractylodis Macrocephalae (stir-fry) 40-120 part, Poria 40-120 part, Cordyceps 5-15 part, Radix Cynanchi Paniculati 79-237 part, Eupolyphaga Seu Steleophaga 40-120 part, Radix Notoginseng 13-39 part, Herba Hedyotidis Diffusae 79-237 part, Herba Scutellariae Barbatae 79-237 part, Massa Medicata Fermentata (stir-fry) 25-75 part.
2, the pharmaceutical composition of human body immunity improving function according to claim 1, its proportion of composing (w/w) comprise 260 parts of the Radixs Astragali, 210 parts of Fructus Ligustri Lucidi, 78 parts of Radix Ginsengs, 80 parts of Ganodermas, 158 parts of Rhizoma Curcumae, 315 parts of Herb Gynostemmae Pentaphylli, 80 parts of the Rhizoma Atractylodis Macrocephalaes (stir-fry), 80 parts in Poria, 10 parts of Cordyceps, 158 parts of Radix Cynanchi Paniculatis, 80 parts of Eupolyphaga Seu Steleophagas, 26 parts of Radix Notoginseng, 158 parts of Herba Hedyotidis Diffusaes, 158 parts of Herba Scutellariae Barbataes, 50 parts of Massa Medicata Fermentata (stir-fry).
3, the pharmaceutical composition of human body immunity improving function according to claim 1, its form also can comprise Radix Codonopsis, Colla Plastri Testudinis, Fructus Psoraleae, rhizoma sparganic, Radix Ophiopogonis, Fructus Lycii, Radix Angelicae Sinensis, Radix Polygoni Multiflori, Radix Rehmanniae Preparata, Rhizoma Zingiberis, Semen Persicae, Radix Rehmanniae, the Rhizoma Anemarrhenae, Fructus Crataegi, Fructus Hordei Germinatus, the Cortex Eucommiae wherein one or more.
4, the preparation of drug combination method of above-mentioned human body immunity improving function comprises:
(1), 78 parts of Radix Ginsengs, 10 parts of Cordyceps, 26 parts of pulverize separately of Radix Notoginseng become fine powder, sieving for standby;
(2), 260 parts of the Radixs Astragali, 210 parts of Fructus Ligustri Lucidi, 80 parts of Ganodermas, 158 parts of Rhizoma Curcumae, 315 parts of Herb Gynostemmae Pentaphylli, 80 parts of the Rhizoma Atractylodis Macrocephalaes (stir-fry), 80 parts in Poria, promptly 158 parts of Xu's length, 80 parts of Eupolyphaga Seu Steleophagas, 158 parts of Herba Hedyotidis Diffusaes, 158 parts of Herba Scutellariae Barbataes, Massa Medicata Fermentata (stir-fry) decoct with water twice for 50 parts, 2 hours for the first time, 1 hour for the second time, merge decoction liquor and filter, filtrate concentrates, drying, be ground into fine powder, with step (1) powder facing-up, the mixing that sieves, encapsulated.
CNB021465711A 2002-10-24 2002-10-24 Medicines composition for raising body's immunity and its prepn CN1188158C (en)

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CN107375896A (en) * 2017-06-26 2017-11-24 郑相国 For suppressing the Chinese patent drug of cancer cell multiplication
CN107468839A (en) * 2017-08-11 2017-12-15 孟广千 The Chinese medicine composition of card disease is considered with Bushen Prescription treatment liver

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