CN1403147A - Medicines composition for raising body's immunity and its prepn - Google Patents
Medicines composition for raising body's immunity and its prepn Download PDFInfo
- Publication number
- CN1403147A CN1403147A CN02146571A CN02146571A CN1403147A CN 1403147 A CN1403147 A CN 1403147A CN 02146571 A CN02146571 A CN 02146571A CN 02146571 A CN02146571 A CN 02146571A CN 1403147 A CN1403147 A CN 1403147A
- Authority
- CN
- China
- Prior art keywords
- parts
- radix
- rhizoma
- stir
- fry
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 230000036039 immunity Effects 0.000 title claims abstract description 14
- 239000003814 drug Substances 0.000 title abstract description 15
- 239000000203 mixture Substances 0.000 title abstract description 7
- 229940079593 drugs Drugs 0.000 title description 7
- 235000003140 Panax quinquefolius Nutrition 0.000 claims abstract description 17
- 235000005035 ginseng Nutrition 0.000 claims abstract description 17
- 235000008434 ginseng Nutrition 0.000 claims abstract description 17
- 241000222336 Ganoderma Species 0.000 claims abstract description 11
- 239000009636 Huang Qi Substances 0.000 claims description 14
- 241001619461 Poria <basidiomycete fungus> Species 0.000 claims description 13
- 239000008194 pharmaceutical composition Substances 0.000 claims description 11
- 239000000843 powder Substances 0.000 claims description 11
- 241000190633 Cordyceps Species 0.000 claims description 10
- 241000180649 Panax notoginseng Species 0.000 claims description 10
- 235000003143 Panax notoginseng Nutrition 0.000 claims description 10
- 241001489978 Eupolyphaga Species 0.000 claims description 9
- 239000010271 massa medicata fermentata Substances 0.000 claims description 9
- 238000002360 preparation method Methods 0.000 claims description 8
- 241000756943 Codonopsis Species 0.000 claims description 5
- 241000545442 Radix Species 0.000 claims description 4
- 210000000582 Semen Anatomy 0.000 claims description 4
- 241001550206 Colla Species 0.000 claims description 3
- 239000012141 concentrate Substances 0.000 claims description 3
- 238000001035 drying Methods 0.000 claims description 3
- 239000000706 filtrate Substances 0.000 claims description 3
- 238000007873 sieving Methods 0.000 claims description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances data:image/svg+xml;base64,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 data:image/svg+xml;base64,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 O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 3
- 239000000890 drug combination Substances 0.000 claims description 2
- 241000208340 Araliaceae Species 0.000 claims 3
- 240000004678 Panax pseudoginseng Species 0.000 abstract description 16
- 210000000952 Spleen Anatomy 0.000 abstract description 10
- 239000002775 capsule Substances 0.000 abstract description 7
- 238000005728 strengthening Methods 0.000 abstract description 7
- CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound data:image/svg+xml;base64,<?xml version='1.0' encoding='iso-8859-1'?>
<svg version='1.1' baseProfile='full'
              xmlns='http://www.w3.org/2000/svg'
                      xmlns:rdkit='http://www.rdkit.org/xml'
                      xmlns:xlink='http://www.w3.org/1999/xlink'
                  xml:space='preserve'
width='300px' height='300px' viewBox='0 0 300 300'>
<!-- END OF HEADER -->
<rect style='opacity:1.0;fill:#FFFFFF;stroke:none' width='300.0' height='300.0' x='0.0' y='0.0'> </rect>
<path class='bond-0 atom-0 atom-1' d='M 260.4,218.7 L 249.8,207.8' style='fill:none;fill-rule:evenodd;stroke:#5BB772;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-0 atom-0 atom-1' d='M 249.8,207.8 L 239.3,196.9' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-1 atom-1 atom-2' d='M 239.3,196.9 L 189.9,209.3' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-2 atom-2 atom-3' d='M 189.9,209.3 L 179.4,198.5' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-2 atom-2 atom-3' d='M 179.4,198.5 L 169.0,187.7' style='fill:none;fill-rule:evenodd;stroke:#4284F4;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-3 atom-3 atom-4' d='M 159.4,155.6 L 163.9,139.8' style='fill:none;fill-rule:evenodd;stroke:#4284F4;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-3 atom-3 atom-4' d='M 163.9,139.8 L 168.4,123.9' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-6 atom-3 atom-7' d='M 137.3,177.1 L 129.6,179.1' style='fill:none;fill-rule:evenodd;stroke:#4284F4;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-6 atom-3 atom-7' d='M 129.6,179.1 L 122.0,181.0' style='fill:none;fill-rule:evenodd;stroke:#FF60B7;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-4 atom-4 atom-5' d='M 168.4,123.9 L 217.7,111.5' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-5 atom-5 atom-6' d='M 217.7,111.5 L 221.7,97.6' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-5 atom-5 atom-6' d='M 221.7,97.6 L 225.6,83.8' style='fill:none;fill-rule:evenodd;stroke:#5BB772;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-7 atom-7 atom-8' d='M 109.8,208.0 L 112.0,212.8' style='fill:none;fill-rule:evenodd;stroke:#FF60B7;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-7 atom-7 atom-8' d='M 112.0,212.8 L 114.1,217.6' style='fill:none;fill-rule:evenodd;stroke:#E84235;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-7 atom-7 atom-8' d='M 119.1,203.9 L 121.3,208.7' style='fill:none;fill-rule:evenodd;stroke:#FF60B7;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-7 atom-7 atom-8' d='M 121.3,208.7 L 123.4,213.5' style='fill:none;fill-rule:evenodd;stroke:#E84235;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-8 atom-7 atom-9' d='M 89.4,195.9 L 83.9,199.7' style='fill:none;fill-rule:evenodd;stroke:#FF60B7;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-8 atom-7 atom-9' d='M 83.9,199.7 L 78.4,203.4' style='fill:none;fill-rule:evenodd;stroke:#4284F4;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-13 atom-13 atom-7' d='M 103.1,156.1 L 103.5,162.2' style='fill:none;fill-rule:evenodd;stroke:#E84235;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-13 atom-13 atom-7' d='M 103.5,162.2 L 104.0,168.2' style='fill:none;fill-rule:evenodd;stroke:#FF60B7;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-9 atom-9 atom-10' d='M 46.5,205.7 L 31.9,198.7' style='fill:none;fill-rule:evenodd;stroke:#4284F4;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-9 atom-9 atom-10' d='M 31.9,198.7 L 17.3,191.6' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-10 atom-10 atom-11' d='M 17.3,191.6 L 13.6,140.8' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-11 atom-11 atom-12' d='M 13.6,140.8 L 55.7,112.3' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-12 atom-12 atom-13' d='M 55.7,112.3 L 70.4,119.4' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-12 atom-12 atom-13' d='M 70.4,119.4 L 85.0,126.5' style='fill:none;fill-rule:evenodd;stroke:#E84235;stroke-width:2.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<text x='268.6' y='243.6' class='atom-0' style='font-size:20px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#5BB772' >C</text>
<text x='282.6' y='243.6' class='atom-0' style='font-size:20px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#5BB772' >l</text>
<text x='148.4' y='183.0' class='atom-3' style='font-size:20px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#4284F4' >N</text>
<text x='225.5' y='72.7' class='atom-6' style='font-size:20px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#5BB772' >C</text>
<text x='239.6' y='72.7' class='atom-6' style='font-size:20px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#5BB772' >l</text>
<text x='99.1' y='195.4' class='atom-7' style='font-size:20px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#FF60B7' >P</text>
<text x='119.9' y='241.8' class='atom-8' style='font-size:20px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#E84235' >O</text>
<text x='57.0' y='223.9' class='atom-9' style='font-size:20px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#4284F4' >N</text>
<text x='57.0' y='241.8' class='atom-9' style='font-size:20px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#4284F4' >H</text>
<text x='95.4' y='144.7' class='atom-13' style='font-size:20px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#E84235' >O</text>
</svg>
 data:image/svg+xml;base64,<?xml version='1.0' encoding='iso-8859-1'?>
<svg version='1.1' baseProfile='full'
              xmlns='http://www.w3.org/2000/svg'
                      xmlns:rdkit='http://www.rdkit.org/xml'
                      xmlns:xlink='http://www.w3.org/1999/xlink'
                  xml:space='preserve'
width='85px' height='85px' viewBox='0 0 85 85'>
<!-- END OF HEADER -->
<rect style='opacity:1.0;fill:#FFFFFF;stroke:none' width='85.0' height='85.0' x='0.0' y='0.0'> </rect>
<path class='bond-0 atom-0 atom-1' d='M 75.2,63.5 L 71.3,59.4' style='fill:none;fill-rule:evenodd;stroke:#5BB772;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-0 atom-0 atom-1' d='M 71.3,59.4 L 67.3,55.3' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-1 atom-1 atom-2' d='M 67.3,55.3 L 53.3,58.8' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-2 atom-2 atom-3' d='M 53.3,58.8 L 49.4,54.7' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-2 atom-2 atom-3' d='M 49.4,54.7 L 45.4,50.7' style='fill:none;fill-rule:evenodd;stroke:#4284F4;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-3 atom-3 atom-4' d='M 43.9,46.3 L 45.6,40.4' style='fill:none;fill-rule:evenodd;stroke:#4284F4;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-3 atom-3 atom-4' d='M 45.6,40.4 L 47.2,34.6' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-6 atom-3 atom-7' d='M 41.1,49.0 L 36.3,50.2' style='fill:none;fill-rule:evenodd;stroke:#4284F4;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-6 atom-3 atom-7' d='M 36.3,50.2 L 31.4,51.4' style='fill:none;fill-rule:evenodd;stroke:#FF60B7;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-4 atom-4 atom-5' d='M 47.2,34.6 L 61.2,31.1' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-5 atom-5 atom-6' d='M 61.2,31.1 L 62.7,25.8' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-5 atom-5 atom-6' d='M 62.7,25.8 L 64.2,20.6' style='fill:none;fill-rule:evenodd;stroke:#5BB772;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-7 atom-7 atom-8' d='M 29.5,55.9 L 31.2,59.8' style='fill:none;fill-rule:evenodd;stroke:#FF60B7;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-7 atom-7 atom-8' d='M 31.2,59.8 L 33.0,63.7' style='fill:none;fill-rule:evenodd;stroke:#E84235;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-7 atom-7 atom-8' d='M 32.1,54.8 L 33.9,58.6' style='fill:none;fill-rule:evenodd;stroke:#FF60B7;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-7 atom-7 atom-8' d='M 33.9,58.6 L 35.6,62.5' style='fill:none;fill-rule:evenodd;stroke:#E84235;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-8 atom-7 atom-9' d='M 27.1,53.4 L 23.3,56.0' style='fill:none;fill-rule:evenodd;stroke:#FF60B7;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-8 atom-7 atom-9' d='M 23.3,56.0 L 19.5,58.6' style='fill:none;fill-rule:evenodd;stroke:#4284F4;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-13 atom-13 atom-7' d='M 28.5,41.0 L 28.8,45.4' style='fill:none;fill-rule:evenodd;stroke:#E84235;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-13 atom-13 atom-7' d='M 28.8,45.4 L 29.2,49.9' style='fill:none;fill-rule:evenodd;stroke:#FF60B7;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-9 atom-9 atom-10' d='M 15.2,59.0 L 9.8,56.4' style='fill:none;fill-rule:evenodd;stroke:#4284F4;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-9 atom-9 atom-10' d='M 9.8,56.4 L 4.4,53.8' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-10 atom-10 atom-11' d='M 4.4,53.8 L 3.4,39.4' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-11 atom-11 atom-12' d='M 3.4,39.4 L 15.3,31.3' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-12 atom-12 atom-13' d='M 15.3,31.3 L 20.7,33.9' style='fill:none;fill-rule:evenodd;stroke:#3B4143;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<path class='bond-12 atom-12 atom-13' d='M 20.7,33.9 L 26.1,36.6' style='fill:none;fill-rule:evenodd;stroke:#E84235;stroke-width:1.0px;stroke-linecap:butt;stroke-linejoin:miter;stroke-opacity:1' />
<text x='75.5' y='68.6' class='atom-0' style='font-size:6px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#5BB772' >C</text>
<text x='79.7' y='68.6' class='atom-0' style='font-size:6px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#5BB772' >l</text>
<text x='41.5' y='51.5' class='atom-3' style='font-size:6px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#4284F4' >N</text>
<text x='63.3' y='20.2' class='atom-6' style='font-size:6px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#5BB772' >C</text>
<text x='67.5' y='20.2' class='atom-6' style='font-size:6px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#5BB772' >l</text>
<text x='27.5' y='55.0' class='atom-7' style='font-size:6px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#FF60B7' >P</text>
<text x='33.4' y='68.1' class='atom-8' style='font-size:6px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#E84235' >O</text>
<text x='15.6' y='63.1' class='atom-9' style='font-size:6px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#4284F4' >N</text>
<text x='15.6' y='68.3' class='atom-9' style='font-size:6px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#4284F4' >H</text>
<text x='26.5' y='40.6' class='atom-13' style='font-size:6px;font-style:normal;font-weight:normal;fill-opacity:1;stroke:none;font-family:sans-serif;text-anchor:start;fill:#E84235' >O</text>
</svg>
 ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 abstract description 5
- 229960004397 Cyclophosphamide Drugs 0.000 abstract description 5
- 206010039491 Sarcoma Diseases 0.000 abstract description 4
- 230000002401 inhibitory effect Effects 0.000 abstract description 4
- 240000006509 Gynostemma pentaphyllum Species 0.000 abstract description 3
- 235000002956 Gynostemma pentaphyllum Nutrition 0.000 abstract description 3
- 210000003734 Kidney Anatomy 0.000 abstract description 3
- 230000000694 effects Effects 0.000 abstract description 3
- 230000000973 chemotherapeutic Effects 0.000 abstract description 2
- 230000000144 pharmacologic effect Effects 0.000 abstract description 2
- 229940107666 ASTRAGALUS ROOT Drugs 0.000 abstract 1
- 241000735234 Ligustrum Species 0.000 abstract 1
- 239000002131 composite material Substances 0.000 abstract 1
- 239000000463 material Substances 0.000 abstract 1
- 230000004083 survival Effects 0.000 abstract 1
- 210000004369 Blood Anatomy 0.000 description 6
- 239000008280 blood Substances 0.000 description 6
- 201000010099 disease Diseases 0.000 description 6
- 210000001015 Abdomen Anatomy 0.000 description 3
- 206010003549 Asthenia Diseases 0.000 description 3
- 206010019641 Hepatic cirrhosis Diseases 0.000 description 3
- 208000006454 Hepatitis Diseases 0.000 description 3
- 206010028980 Neoplasm Diseases 0.000 description 3
- 231100000614 Poison Toxicity 0.000 description 3
- 210000002784 Stomach Anatomy 0.000 description 3
- 235000019525 fullness Nutrition 0.000 description 3
- 231100000283 hepatitis Toxicity 0.000 description 3
- 201000004044 liver cirrhosis Diseases 0.000 description 3
- 239000002574 poison Substances 0.000 description 3
- 241000132012 Atractylodes Species 0.000 description 2
- 241001233914 Chelidonium majus Species 0.000 description 2
- 235000014375 Curcuma Nutrition 0.000 description 2
- 240000002123 Curcuma aromatica Species 0.000 description 2
- 240000009138 Curcuma zedoaria Species 0.000 description 2
- 235000003405 Curcuma zedoaria Nutrition 0.000 description 2
- 241000628997 Flos Species 0.000 description 2
- 206010061598 Immunodeficiency Diseases 0.000 description 2
- 241000830535 Ligustrum lucidum Species 0.000 description 2
- 240000001659 Oldenlandia diffusa Species 0.000 description 2
- 241001248610 Ophiocordyceps sinensis Species 0.000 description 2
- 235000003181 Panax pseudoginseng Nutrition 0.000 description 2
- 244000197580 Poria cocos Species 0.000 description 2
- 235000008599 Poria cocos Nutrition 0.000 description 2
- 235000019789 appetite Nutrition 0.000 description 2
- 230000036528 appetite Effects 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 239000001812 curcuma zedoaria berg. rosc. Substances 0.000 description 2
- 235000013399 edible fruits Nutrition 0.000 description 2
- 230000001900 immune effect Effects 0.000 description 2
- 230000003014 reinforcing Effects 0.000 description 2
- 235000019509 white turmeric Nutrition 0.000 description 2
- 101710036216 ATEG_03556 Proteins 0.000 description 1
- 235000016855 Biancospino Nutrition 0.000 description 1
- 210000001124 Body Fluids Anatomy 0.000 description 1
- 235000017181 Crataegus chrysocarpa Nutrition 0.000 description 1
- 235000004423 Crataegus monogyna Nutrition 0.000 description 1
- 240000000171 Crataegus monogyna Species 0.000 description 1
- 241000721047 Danaus plexippus Species 0.000 description 1
- 240000001008 Dimocarpus longan Species 0.000 description 1
- 241000668709 Dipterocarpus costatus Species 0.000 description 1
- 208000003468 Ehrlich Tumor Carcinoma Diseases 0.000 description 1
- 235000000235 Euphoria longan Nutrition 0.000 description 1
- 102000015696 Interleukins Human genes 0.000 description 1
- 108010063738 Interleukins Proteins 0.000 description 1
- 210000004072 Lung Anatomy 0.000 description 1
- 101700015696 PHL12 Proteins 0.000 description 1
- 240000005158 Phaseolus vulgaris Species 0.000 description 1
- 229920001231 Polysaccharide peptide Polymers 0.000 description 1
- 241000700159 Rattus Species 0.000 description 1
- 210000002966 Serum Anatomy 0.000 description 1
- 101700003161 TXLR2 Proteins 0.000 description 1
- 231100000215 acute (single dose) toxicity testing Toxicity 0.000 description 1
- 238000011047 acute toxicity test Methods 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 230000000240 adjuvant Effects 0.000 description 1
- 101710024925 alv Proteins 0.000 description 1
- 101700053124 asa1 Proteins 0.000 description 1
- 239000010839 body fluid Substances 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 230000001413 cellular Effects 0.000 description 1
- 231100000160 chronic toxicity Toxicity 0.000 description 1
- 230000002950 deficient Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000002708 enhancing Effects 0.000 description 1
- 239000000284 extract Substances 0.000 description 1
- 239000000796 flavoring agent Substances 0.000 description 1
- 235000019634 flavors Nutrition 0.000 description 1
- 230000037406 food intake Effects 0.000 description 1
- 235000012631 food intake Nutrition 0.000 description 1
- 239000010135 fructus aurantii immaturus Substances 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 235000002313 hawthorn Nutrition 0.000 description 1
- 235000009444 hawthorn Nutrition 0.000 description 1
- 235000009486 hawthorn Nutrition 0.000 description 1
- 235000009682 hawthorn Nutrition 0.000 description 1
- 235000009685 hawthorn Nutrition 0.000 description 1
- 235000009917 hawthorn Nutrition 0.000 description 1
- 235000013161 hawthorn Nutrition 0.000 description 1
- 235000013165 hawthorn Nutrition 0.000 description 1
- 235000013189 hawthorn Nutrition 0.000 description 1
- 235000013204 hawthorn Nutrition 0.000 description 1
- 235000013214 hawthorn Nutrition 0.000 description 1
- 235000013246 hawthorn Nutrition 0.000 description 1
- 235000017423 hawthorn Nutrition 0.000 description 1
- 239000003228 hemolysin Substances 0.000 description 1
- 101700027420 hly Proteins 0.000 description 1
- 230000003053 immunization Effects 0.000 description 1
- 238000002649 immunization Methods 0.000 description 1
- 235000021332 kidney beans Nutrition 0.000 description 1
- 231100000682 maximum tolerated dose Toxicity 0.000 description 1
- 210000000056 organs Anatomy 0.000 description 1
- 230000001717 pathogenic Effects 0.000 description 1
- 101700005116 plc Proteins 0.000 description 1
- 108010022457 polysaccharide peptide Proteins 0.000 description 1
- 239000008517 radix Trichosanthis Substances 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 239000008687 shenqi fuzheng Substances 0.000 description 1
- 101710010431 shlA Proteins 0.000 description 1
- 230000002195 synergetic Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
Abstract
The present invention provides one medicine composition for raising body's immunity and invigorating spleen and kidney based on the Chinese medicine theory of strengthening body's resistance to eliminate evil. The medicine composition has 15 kinds of Chinese medicinal materials including astragalus root, privet seed, ginseng, glossy ganoderma, gynostemma pentaphylla, etc. The pharmacological test shows that the composite medicine capsule has obvious effects of inhibiting the growth of mouse's S180 sarcoma, prolonging the survival days of the mouse and raising the inhibition of chemotherapeutic medicine cyclophosphamide to mouse's S180 sarcoma.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition of human body immunity improving function, belong to the Chinese herbal and crude drugs preparations technical field, be particularly useful for treating clinically deficiency of spleen and stomach such as tumor, hepatitis, liver cirrhosis, diseases such as emaciated physique, fatigue and asthenia, distension and fullness in the abdomen due to the combined symptoms in the stasis of blood poison.
Background technology
" deficient " category of diseases genus motherland medical science such as emaciated physique, fatigue and asthenia, distension and fullness in the abdomen due to the combined symptoms in the deficiency of spleen and stomach such as tumor, hepatitis, liver cirrhosis, stasis of blood poison.At present, the Chinese medicine preparation of treatment immunocompromised, as Radix codonopsis pilosulae's soft extract (invigorating the spleen and replenishing QI, the spleen invigorating lung benefiting), Polysaccharide-peptide capsule (nourishing the essence and strengthening QI, invigorating spleen and nourishing heart), ten flavor body-strengthening granules (benefiting vital QI and blood, warming YANG and strengthening the spleen), SHENQI FUZHENG ZHUSHEYE (QI invigorating is set upright), ginseng one capsule (element culturing fixed folder, benefiting vital QI and blood), they are partial to mend more, and are too unilateral.It is considered herein that diseases such as emaciated physique that immunocompromised disease occurs, fatigue and asthenia, spiritlessness and sparing of words, poor appetite lack of appetite, distension and fullness in the abdomen are deficiency of spleen and stomach, tie in the stasis of blood poison and cause, card for deficiency in origin and excess in superficiality, so with strengthening spleen, tonifying kidney, dissolving blood stasis and detoxication is the rule of treatment, starts with from treating both the principal and secondary aspects of a disease, can obviously improve body fluid and cellular immunization function, thereby enhancing resistance against diseases, but and physical strength reinforcing.
Summary of the invention
The present invention provides a kind of with the human body immunity improving function with traditional Chinese medical science strengthening vital QI to eliminate pathogenic factors theory, and the pharmaceutical composition of strengthening spleen, tonifying kidney reaches treating both the principal and secondary aspects of a disease.
Technical scheme of the present invention is achieved in that the pharmaceutical composition of this human body immunity improving function, and its proportion of composing (w/w) comprises Radix Astragali 130-390 part, Fructus Ligustri Lucidi 105-315 part, Radix Ginseng 39-117 part, Ganoderma 40-120 part, Rhizoma Curcumae 79-327 part, Herb Gynostemmae Pentaphylli 157-473 part, the Rhizoma Atractylodis Macrocephalae (stir-fry) 40-120 part, Poria 40-120 part, Cordyceps 5-15 part, Radix Cynanchi Paniculati 79-237 part, Eupolyphaga Seu Steleophaga 40-120 part, Radix Notoginseng 13-39 part, Herba Hedyotidis Diffusae 79-237 part, Herba Scutellariae Barbatae 79-237 part, Massa Medicata Fermentata (stir-fry) 25-75 part.
The pharmaceutical composition of described human body immunity improving function, its proportion of composing (w/w) comprise 260 parts of the Radixs Astragali, 210 parts of Fructus Ligustri Lucidi, 78 parts of Radix Ginsengs, 80 parts of Ganodermas, 158 parts of Rhizoma Curcumae, 315 parts of Herb Gynostemmae Pentaphylli, 80 parts of the Rhizoma Atractylodis Macrocephalaes (stir-fry), 80 parts in Poria, 10 parts of Cordyceps, 158 parts of Radix Cynanchi Paniculatis, 80 parts of Eupolyphaga Seu Steleophagas, 26 parts of Radix Notoginseng, 158 parts of Herba Hedyotidis Diffusaes, 158 parts of Herba Scutellariae Barbataes, 50 parts of Massa Medicata Fermentata (stir-fry).
The pharmaceutical composition of described human body immunity improving function, its form also can comprise Radix Codonopsis, Colla Plastri Testudinis, Fructus Psoraleae, rhizoma sparganic, Radix Ophiopogonis, Fructus Lycii, Radix Angelicae Sinensis, Radix Polygoni Multiflori, Radix Rehmanniae Preparata, Rhizoma Zingiberis, Semen Persicae, Radix Rehmanniae, the Rhizoma Anemarrhenae, Fructus Crataegi, Fructus Hordei Germinatus, the Cortex Eucommiae wherein one or more.
The preparation of drug combination method of above-mentioned human body immunity improving function comprises:
(1), 78 parts of Radix Ginsengs, 10 parts of Cordyceps, 26 parts of pulverize separately of Radix Notoginseng become fine powder, sieving for standby;
(2), 260 parts of the Radixs Astragali, 210 parts of Fructus Ligustri Lucidi, 80 parts of Ganodermas, 158 parts of Rhizoma Curcumae, 315 parts of Herb Gynostemmae Pentaphylli, 80 parts of the Rhizoma Atractylodis Macrocephalaes (stir-fry), 80 parts in Poria, promptly 158 parts of Xu's length, 80 parts of Eupolyphaga Seu Steleophagas, 158 parts of Herba Hedyotidis Diffusaes, 158 parts of Herba Scutellariae Barbataes, Massa Medicata Fermentata (stir-fry) decoct with water twice for 50 parts, 2 hours for the first time, 1 hour for the second time, merge decoction liquor and filter, filtrate concentrates, drying, be ground into fine powder, with step (1) powder facing-up, the mixing that sieves, encapsulated.
The pharmaceutical composition of above-mentioned human body immunity improving function can also be used for preparing clinically the base stock of oral formulations such as tablet, electuary, powder.
Pharmacological testing studies show that through the college of traditional Chinese medicine of Hebei Medical University, and medicament composition capsule of the present invention (trade name is for the strange capsule of China or join clever blue capsule) is to mice S
180The growth of sarcoma has obvious inhibitory action, can prolong ehrlich ascites tumor mice existence natural law, share mice S with the chemotherapeutics cyclophosphamide
180The inhibitory action of sarcoma has the notable synergistic effect, the mice serum hemolysin of caused by cyclophosphamide immunologic hypofunction is obviously raise, the splenocyte conversion ratio obviously increases, cyclophosphamide is caused the murine interleukin minimizing reverse effect, and cyclophosphamide is caused the minimizing of mice food-intake the increase effect.
Acute toxicity test in mice shows that the clinical consumption of capsule of the present invention is 6g/ day, and the oral maximum tolerated dose of mice is 20.0g/kg, 232.6 times of the clinical consumption that is equivalent to be grown up, animal Non Apparent Abnormality and death.Long term toxicity test shows: the present invention does not all have obvious influence to biochemical indicator such as the general situation of rat, body weight, hemogram and main organs coefficient, illustrates that the present invention does not have the overt toxicity reaction.See Appendix.
The specific embodiment
Example below in conjunction with drug regimen of the present invention illustrates the specific embodiment of the present invention.
Embodiment 1: the Radix Astragali 260g Fructus Ligustri Lucidi 210g Radix Ginseng 78g Ganoderma 80g Rhizoma Curcumae 158g Herb Gynostemmae Pentaphylli 315g Rhizoma Atractylodis Macrocephalae (stir-fry) 80g Poria 80g Cordyceps 10g Radix Cynanchi Paniculati 158g Eupolyphaga Seu Steleophaga 80g Radix Notoginseng 26g Herba Hedyotidis Diffusae 158g Herba Scutellariae Barbatae 158g Massa Medicata Fermentata (stir-fry) 50g preparation method:
(1), Radix Ginseng, Cordyceps, Radix Notoginseng pulverize separately become fine powder, sieving for standby;
(2), all the other medicines decoct with water twice, 2 hours for the first time, 1 hour for the second time, merge decoction liquor and filter, filtrate concentrates, drying is ground into fine powder, and is with step (1) powder facing-up, the mixing that sieves, encapsulated.
Embodiment 2: the Radix Astragali 150g fruit of glossy privet 100g ginseng 40g glossy ganoderma 80g curcuma zedoary 80g gynostemma pentaphylla 150g bighead atractylodes rhizome (stir-fry) 160g Poria cocos 80g Cordyceps sinensis 10g paniculate swallowwort 158g ground bettle 40g pseudo-ginseng 15g oldenlandia diffusa 158g Sculellaria barbata 80g hawthorn (stir-fry) 50g embodiment 3: the Radix Astragali 500g fruit of glossy privet 400g ginseng 150g glossy ganoderma 80g curcuma zedoary 320g gynostemma pentaphylla 600g bighead atractylodes rhizome (stir-fry) 40g Poria cocos 80g Cordyceps sinensis 10g paniculate swallowwort 158g ground bettle 160g pseudo-ginseng 50g oldenlandia diffusa 158g Sculellaria barbata 300g Fructus Hordei Germinatus (stir-fry) 50g
Embodiment 4: the Radix Astragali 500g Rhizoma Atractylodis Macrocephalae (stir-fry) 160g Radix Ginseng 150g Poria 160g rhizoma sparganic 320g Herb Gynostemmae Pentaphylli 600g Herba Hedyotidis Diffusae 300g Herba Scutellariae Barbatae 300g Rhizoma Dioscoreae 250g Arillus Longan 150g Fructus Lycii 150g Radix Polygoni Multiflori Preparata 86g Caulis Spatholobi 89g Radix Glycyrrhizae 90g
Embodiment 5: each 120 rhizoma sparganic 320g Herb Gynostemmae Pentaphylli 600g Herba Hedyotidis Diffusae 300g Herba Scutellariae Barbatae 300g Fructus Ligustri Lucidi 210g 160g Radix Ophiopogonis Fructus Lycii 150g Radix Angelicae Sinensis 89g Colla Plastri Testudinis 86g Fructus Crataegi 100g of the red Radix Paeoniae Alba of the Radix Astragali 500g Rhizoma Atractylodis Macrocephalae (stir-fry) 160g Radix Ginseng 150g
Embodiment 6: Radix Astragali 450g 220g Radix Ophiopogonis Radix Scrophulariae 120g Rhizoma dioscoreae 89g Fructus Lycii 90g Rhizoma Anemarrhenae 67g Rhizoma Polygonati Odorati 68g Herb Gynostemmae Pentaphylli 600g Herba Hedyotidis Diffusae 300g Herba Scutellariae Barbatae 300g Fructus Schisandrae Chinensis 45g Radix Trichosanthis 68
Embodiment 7: Radix Astragali 450g Radix Ginseng 150g Radix Aconiti Lateralis Preparata 45g Herba Epimedii 68g Rhizoma Curculiginis 35g Fructus Psoraleae 89g Cordyceps 10g Cortex Eucommiae 86g Herba Hedyotidis Diffusae 300g Herba Scutellariae Barbatae 300g 150g Radix Ophiopogonis Radix Rehmanniae 150g Radix Glycyrrhizae 90g
Embodiment 8: Radix Codonopsis 220g Radix Astragali 250g Rhizoma Atractylodis Macrocephalae 180g Rhizoma dioscoreae 98g stir-fried kidney beans 120g Poria 150g Rhizoma Curcumae 158g Herb Gynostemmae Pentaphylli 315g Herba Scutellariae Barbatae 158g gives birth to Semen Coicis 86g Pericarpium Citri Reticulatae 68g Radix Glycyrrhizae 90g
Embodiment 9: Radix Codonopsis 450g Radix Astragali 250g Rhizoma Atractylodis Macrocephalae 120g Rhizoma dioscoreae 68g Poria 76g Rhizoma Alismatis 35g Cortex Cinnamomi 86g Semen Cuscutae 120g Fructus Ligustri Lucidi 210g Fructus Corni 86g Radix Rehmanniae 86g Fructus Psoraleae 98g Fructus Lycii 68g Pericarpium Citri Reticulatae 98g Radix Cyathulae 68
Embodiment 10: the Radix Astragali (processing) 450g Rhizoma Atractylodis Macrocephalae 220g Fructus Ligustri Lucidi 210g Poria 80g Herba Scutellariae Barbatae 158g Rhizoma Curcumae 158g Cortex Magnoliae Officinalis 65g Fructus Aurantii Immaturus 56g Pericarpium Citri Reticulatae 98g Fructus Lycii 86g FLOS MUME 50g Radix Ginseng 45g Massa Medicata Fermentata (stir-fry) 45g Radix Glycyrrhizae 90gg
Embodiment 11: each 86g rhizoma sparganic 180g Eupolyphaga Seu Steleophaga 80g Radix Notoginseng 26g Radix Polygoni Multiflori Preparata 86g Radix Salviae Miltiorrhizae 110g Poria 86g Rhizoma Dioscoreae 86g Radix Cyathulae 120g Flos Carthami 86g Radix Glycyrrhizae 90g of the red Radix Paeoniae Alba of Radix Astragali 450g Rhizoma Atractylodis Macrocephalae 220g Radix Angelicae Sinensis 35g Radix Rehmanniae Preparata 150g
The preparation method of embodiment 2-11 and embodiment 1 are basic identical.
The mixture that the preparation method of the foregoing description is made can be used for preparing clinically the base stock of oral formulations such as tablet, electuary, powder.
Pharmaceutical composition of the present invention is monarch with the Radix Astragali, Fructus Ligustri Lucidi, with Radix Ginseng, Ganoderma, Rhizoma Curcumae, Herb Gynostemmae Pentaphylli is ministerial drug, the Rhizoma Atractylodis Macrocephalae, Poria, Cordyceps, Radix Cynanchi Paniculati, Eupolyphaga Seu Steleophaga, Radix Notoginseng, Herba Hedyotidis Diffusae are adjuvant drug altogether, Herba Scutellariae Barbatae, Massa Medicata Fermentata are for making, the tumor that causes for immunologic hypofunction, hepatitis, liver cirrhosis etc. all can be used as the treatment ancillary drug and use, but physical strength reinforcing is resisted exopathogen, makes the body early recovery.
Claims (4)
1, a kind of pharmaceutical composition of human body immunity improving function, its proportion of composing (w/w) comprise Radix Astragali 130-390 part, Fructus Ligustri Lucidi 105-315 part, Radix Ginseng 39-117 part, Ganoderma 40-120 part, Rhizoma Curcumae 79-327 part, Herb Gynostemmae Pentaphylli 157-473 part, the Rhizoma Atractylodis Macrocephalae (stir-fry) 40-120 part, Poria 40-120 part, Cordyceps 5-15 part, Radix Cynanchi Paniculati 79-237 part, Eupolyphaga Seu Steleophaga 40-120 part, Radix Notoginseng 13-39 part, Herba Hedyotidis Diffusae 79-237 part, Herba Scutellariae Barbatae 79-237 part, Massa Medicata Fermentata (stir-fry) 25-75 part.
2, the pharmaceutical composition of human body immunity improving function according to claim 1, its proportion of composing (w/w) comprise 260 parts of the Radixs Astragali, 210 parts of Fructus Ligustri Lucidi, 78 parts of Radix Ginsengs, 80 parts of Ganodermas, 158 parts of Rhizoma Curcumae, 315 parts of Herb Gynostemmae Pentaphylli, 80 parts of the Rhizoma Atractylodis Macrocephalaes (stir-fry), 80 parts in Poria, 10 parts of Cordyceps, 158 parts of Radix Cynanchi Paniculatis, 80 parts of Eupolyphaga Seu Steleophagas, 26 parts of Radix Notoginseng, 158 parts of Herba Hedyotidis Diffusaes, 158 parts of Herba Scutellariae Barbataes, 50 parts of Massa Medicata Fermentata (stir-fry).
3, the pharmaceutical composition of human body immunity improving function according to claim 1, its form also can comprise Radix Codonopsis, Colla Plastri Testudinis, Fructus Psoraleae, rhizoma sparganic, Radix Ophiopogonis, Fructus Lycii, Radix Angelicae Sinensis, Radix Polygoni Multiflori, Radix Rehmanniae Preparata, Rhizoma Zingiberis, Semen Persicae, Radix Rehmanniae, the Rhizoma Anemarrhenae, Fructus Crataegi, Fructus Hordei Germinatus, the Cortex Eucommiae wherein one or more.
4, the preparation of drug combination method of above-mentioned human body immunity improving function comprises:
(1), 78 parts of Radix Ginsengs, 10 parts of Cordyceps, 26 parts of pulverize separately of Radix Notoginseng become fine powder, sieving for standby;
(2), 260 parts of the Radixs Astragali, 210 parts of Fructus Ligustri Lucidi, 80 parts of Ganodermas, 158 parts of Rhizoma Curcumae, 315 parts of Herb Gynostemmae Pentaphylli, 80 parts of the Rhizoma Atractylodis Macrocephalaes (stir-fry), 80 parts in Poria, promptly 158 parts of Xu's length, 80 parts of Eupolyphaga Seu Steleophagas, 158 parts of Herba Hedyotidis Diffusaes, 158 parts of Herba Scutellariae Barbataes, Massa Medicata Fermentata (stir-fry) decoct with water twice for 50 parts, 2 hours for the first time, 1 hour for the second time, merge decoction liquor and filter, filtrate concentrates, drying, be ground into fine powder, with step (1) powder facing-up, the mixing that sieves, encapsulated.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB021465711A CN1188158C (en) | 2002-10-24 | 2002-10-24 | Medicines composition for raising body's immunity and its prepn |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB021465711A CN1188158C (en) | 2002-10-24 | 2002-10-24 | Medicines composition for raising body's immunity and its prepn |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1403147A true CN1403147A (en) | 2003-03-19 |
| CN1188158C CN1188158C (en) | 2005-02-09 |
Family
ID=4751111
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB021465711A Active CN1188158C (en) | 2002-10-24 | 2002-10-24 | Medicines composition for raising body's immunity and its prepn |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1188158C (en) |
Cited By (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101773548A (en) * | 2010-03-25 | 2010-07-14 | 云南金泰得三七产业股份有限公司 | Pharmaceutical composition for improving immunity |
| CN101455391B (en) * | 2008-11-27 | 2012-04-25 | 成都润馨堂药业有限公司 | Nutrient health-care food capable of immunomodulating and preparation method thereof |
| CN101607058B (en) * | 2008-06-20 | 2012-06-27 | 河北以岭医药研究院有限公司 | Application of Chinese medicinal composition in preparing medicament for treating chronic nephritis |
| CN101607059B (en) * | 2008-06-20 | 2012-06-27 | 河北以岭医药研究院有限公司 | Application of Chinese medicinal composition in preparing medicament for treating and preventing radiation injury |
| CN102526283A (en) * | 2011-11-02 | 2012-07-04 | 宁波海逸生物科技有限公司 | Health-care medicine formula with functions of enhancing immunity, alleviating physical fatigue and resisting tumor |
| CN102772523A (en) * | 2012-08-09 | 2012-11-14 | 谢瑜 | Bitter glossy ganoderma composition for oncotherapy and preparation method of bitter glossy ganoderma composition |
| CN102961497A (en) * | 2012-11-29 | 2013-03-13 | 王吉坤 | Chinese herbal compound prescription used for treating chronic diarrhea |
| CN103405590A (en) * | 2013-08-16 | 2013-11-27 | 山西省中医药研究院 | Traditional Chinese medicine preparation having effect of immunoregulation and preparation method thereof |
| CN103749821A (en) * | 2013-12-31 | 2014-04-30 | 青岛恒波仪器有限公司 | Gynostemma pentaphyllum health-care tea capable of enhancing immunity and preparation method thereof |
| CN103768519A (en) * | 2013-12-25 | 2014-05-07 | 江苏省中医院 | Compound medicine capable of improving anti-tumor curative effect of phosphamide and preparation method thereof |
| CN104013721A (en) * | 2014-05-07 | 2014-09-03 | 娄志 | Kidney-tonifying traditional Chinese medicine |
| CN104107388A (en) * | 2013-04-17 | 2014-10-22 | 天津药物研究院 | Immunity-enhancing and anti-tumor compound traditional Chinese medicine composition, preparation method and application thereof |
| CN104398971A (en) * | 2014-11-04 | 2015-03-11 | 王松华 | Traditional Chinese medicine composition for treating liver cirrhosis, and preparation method and application thereof |
| CN104415132A (en) * | 2013-08-21 | 2015-03-18 | 上海圣赐康生物医药科技有限公司 | Compound formula for preparing soft capsule by pro-liposomes of ganoderma spore and freshwater mussel and preparation method thereof |
| CN104474458A (en) * | 2014-11-24 | 2015-04-01 | 宋海燕 | Traditional Chinese medicine composition |
| CN104547334A (en) * | 2015-01-27 | 2015-04-29 | 邹士东 | Traditional Chinese medicine composition for treating autoimmune hepatitis and preparation method of traditional Chinese medicine composition |
| CN104547606A (en) * | 2014-06-26 | 2015-04-29 | 安徽霍山县药王谷林农科技有限公司 | Dendrobium huoshanense-ginseng-radix astragali preparata health granule for strengthening body resistance |
| CN105535356A (en) * | 2014-11-03 | 2016-05-04 | 谢芳 | Traditional Chinese medicinal ointment and preparation method thereof |
| CN106173400A (en) * | 2016-07-20 | 2016-12-07 | 云南富斌养殖有限公司 | A kind of method of standardization cultivation pig |
| CN106421665A (en) * | 2016-11-24 | 2017-02-22 | 江苏省中医院 | Application of compound traditional Chinese medicine composition to preparation of human immunity improving drug |
| CN107375896A (en) * | 2017-06-26 | 2017-11-24 | 郑相国 | For suppressing the Chinese patent drug of cancer cell multiplication |
| CN107468839A (en) * | 2017-08-11 | 2017-12-15 | 孟广千 | The Chinese medicine composition of card disease is considered with Bushen Prescription treatment liver |
| CN107837364A (en) * | 2016-09-19 | 2018-03-27 | 河北以岭医药研究院有限公司 | A kind of application of Chinese medicine composition in the medicine for preparing prevention metastases |
| CN111557968A (en) * | 2020-03-17 | 2020-08-21 | 常州市中医医院 | Traditional Chinese medicine compound composition with function of regulating immunity and application thereof |
-
2002
- 2002-10-24 CN CNB021465711A patent/CN1188158C/en active Active
Cited By (33)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101607058B (en) * | 2008-06-20 | 2012-06-27 | 河北以岭医药研究院有限公司 | Application of Chinese medicinal composition in preparing medicament for treating chronic nephritis |
| CN101607059B (en) * | 2008-06-20 | 2012-06-27 | 河北以岭医药研究院有限公司 | Application of Chinese medicinal composition in preparing medicament for treating and preventing radiation injury |
| CN101455391B (en) * | 2008-11-27 | 2012-04-25 | 成都润馨堂药业有限公司 | Nutrient health-care food capable of immunomodulating and preparation method thereof |
| CN101773548A (en) * | 2010-03-25 | 2010-07-14 | 云南金泰得三七产业股份有限公司 | Pharmaceutical composition for improving immunity |
| CN101773548B (en) * | 2010-03-25 | 2011-12-21 | 云南金泰得三七产业股份有限公司 | Pharmaceutical composition for improving immunity |
| CN102526283A (en) * | 2011-11-02 | 2012-07-04 | 宁波海逸生物科技有限公司 | Health-care medicine formula with functions of enhancing immunity, alleviating physical fatigue and resisting tumor |
| CN102772523A (en) * | 2012-08-09 | 2012-11-14 | 谢瑜 | Bitter glossy ganoderma composition for oncotherapy and preparation method of bitter glossy ganoderma composition |
| CN102772523B (en) * | 2012-08-09 | 2014-11-19 | 谢瑜 | Bitter glossy ganoderma composition for oncotherapy and preparation method of bitter glossy ganoderma composition |
| CN102961497A (en) * | 2012-11-29 | 2013-03-13 | 王吉坤 | Chinese herbal compound prescription used for treating chronic diarrhea |
| CN102961497B (en) * | 2012-11-29 | 2014-04-02 | 王吉坤 | Chinese herbal compound prescription used for treating chronic diarrhea |
| CN104107388B (en) * | 2013-04-17 | 2017-09-12 | 天津药物研究院 | One kind improves immunity anti-tumor compound Chinese medicine composition and its production and use |
| CN104107388A (en) * | 2013-04-17 | 2014-10-22 | 天津药物研究院 | Immunity-enhancing and anti-tumor compound traditional Chinese medicine composition, preparation method and application thereof |
| CN103405590A (en) * | 2013-08-16 | 2013-11-27 | 山西省中医药研究院 | Traditional Chinese medicine preparation having effect of immunoregulation and preparation method thereof |
| CN103405590B (en) * | 2013-08-16 | 2016-01-20 | 山西省中医药研究院 | A kind of Chinese medicine preparation and preparation method with immunoregulation effect |
| CN104415132A (en) * | 2013-08-21 | 2015-03-18 | 上海圣赐康生物医药科技有限公司 | Compound formula for preparing soft capsule by pro-liposomes of ganoderma spore and freshwater mussel and preparation method thereof |
| CN103768519B (en) * | 2013-12-25 | 2016-08-17 | 江苏省中医院 | A kind of compound medicine improving cyclophosphamide antitumor curative effect and preparation method thereof |
| CN103768519A (en) * | 2013-12-25 | 2014-05-07 | 江苏省中医院 | Compound medicine capable of improving anti-tumor curative effect of phosphamide and preparation method thereof |
| CN103749821B (en) * | 2013-12-31 | 2015-12-09 | 张绪伟 | A kind of gynostemma pentaphylla health-care tea improving immunity and preparation method thereof |
| CN103749821A (en) * | 2013-12-31 | 2014-04-30 | 青岛恒波仪器有限公司 | Gynostemma pentaphyllum health-care tea capable of enhancing immunity and preparation method thereof |
| CN104013721A (en) * | 2014-05-07 | 2014-09-03 | 娄志 | Kidney-tonifying traditional Chinese medicine |
| CN104547606A (en) * | 2014-06-26 | 2015-04-29 | 安徽霍山县药王谷林农科技有限公司 | Dendrobium huoshanense-ginseng-radix astragali preparata health granule for strengthening body resistance |
| CN105535356A (en) * | 2014-11-03 | 2016-05-04 | 谢芳 | Traditional Chinese medicinal ointment and preparation method thereof |
| CN104398971A (en) * | 2014-11-04 | 2015-03-11 | 王松华 | Traditional Chinese medicine composition for treating liver cirrhosis, and preparation method and application thereof |
| CN104474458A (en) * | 2014-11-24 | 2015-04-01 | 宋海燕 | Traditional Chinese medicine composition |
| CN104547334A (en) * | 2015-01-27 | 2015-04-29 | 邹士东 | Traditional Chinese medicine composition for treating autoimmune hepatitis and preparation method of traditional Chinese medicine composition |
| CN106173400A (en) * | 2016-07-20 | 2016-12-07 | 云南富斌养殖有限公司 | A kind of method of standardization cultivation pig |
| CN107837364A (en) * | 2016-09-19 | 2018-03-27 | 河北以岭医药研究院有限公司 | A kind of application of Chinese medicine composition in the medicine for preparing prevention metastases |
| CN107837364B (en) * | 2016-09-19 | 2021-05-04 | 河北以岭医药研究院有限公司 | Application of traditional Chinese medicine composition in preparation of medicine for inhibiting ovarian cancer metastasis |
| CN106421665A (en) * | 2016-11-24 | 2017-02-22 | 江苏省中医院 | Application of compound traditional Chinese medicine composition to preparation of human immunity improving drug |
| CN106421665B (en) * | 2016-11-24 | 2019-06-18 | 江苏省中医院 | A kind of compound traditional Chinese medicine composite improves the immunity of the human body the application in drug in preparation |
| CN107375896A (en) * | 2017-06-26 | 2017-11-24 | 郑相国 | For suppressing the Chinese patent drug of cancer cell multiplication |
| CN107468839A (en) * | 2017-08-11 | 2017-12-15 | 孟广千 | The Chinese medicine composition of card disease is considered with Bushen Prescription treatment liver |
| CN111557968A (en) * | 2020-03-17 | 2020-08-21 | 常州市中医医院 | Traditional Chinese medicine compound composition with function of regulating immunity and application thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN1188158C (en) | 2005-02-09 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN1188158C (en) | Medicines composition for raising body's immunity and its prepn | |
| CN100356972C (en) | Chinese medicine for treating amblyopia and myopia | |
| CN1403148A (en) | Medicines composition for treating coronary heart disease ventricular premature beat and its prepn | |
| CN105920085A (en) | Composition with attenuation efficacy and preparation method thereof and application thereof | |
| CN102319407B (en) | Traditional Chinese medicine for treating gastroptosis and extraction method thereof | |
| CN101259190A (en) | Chinese medicine assembly for warming kidney, compensating spleen, benefitting qi and nourishing blood and preparation thereof | |
| CN100361689C (en) | Granular composition for reducing blood fat and process for producing the same | |
| CN103230548B (en) | Traditional Chinese medicine composition for treating pulmonary heart disease | |
| CN102085316A (en) | Medical composition with effect of tonifying spleen | |
| CN101264220A (en) | Medicaments assembly for tonifying kidney and invigorating spleen, activating blood circulation and removing stasis and preparation thereof | |
| CN101062368A (en) | Chinese traditional medicine for treating cirrhosis ascites | |
| CN101125185A (en) | Traditional Chinese medicine for treating fatty liver | |
| CN103550506A (en) | Traditional Chinese medicine composition cooperatively used in radiotherapy | |
| CN102688445B (en) | Traditional Chinese medicine for treating diabetes and preparation method thereof | |
| CN1332707C (en) | Formula of Chinese herbal medicine decoction distinguished from males and females and combined with Western medicine for curing hepatitis B | |
| CN1186687A (en) | Cancer preventing curing medicine series and its preparation | |
| CN101537134A (en) | Chinese traditional medicine preparation for curing ascites due to cirrhosis | |
| CN111000969A (en) | Pharmaceutical composition for treating simple obesity and preparation method thereof | |
| CN105079437A (en) | Traditional Chinese medicine healthcare preparation used for prolonging life | |
| CN103705731B (en) | A kind of Chinese medicine composition for the treatment of chronic alcoholic toxic liver disease | |
| CN102813733A (en) | Herb tea capable of resisting cancer, preventing diabetes mellitus and enhancing immunity | |
| CN106362035A (en) | Medicine for treating postpartum sweating disease | |
| CN101732568B (en) | Chinese medicinal oral liquid for treating cancer and preparation method thereof | |
| CN112717081B (en) | Blood-activating face-beautifying cream formula and application thereof | |
| CN105878901A (en) | Traditional Chinese medicine preparation for treating skin flap necrosis after breast cancer operation and preparation method |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| C06 | Publication | ||
| PB01 | Publication | ||
| C10 | Entry into substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| C14 | Grant of patent or utility model | ||
| GR01 | Patent grant | ||
| ASS | Succession or assignment of patent right |
Owner name: SHIJIAZHUANG YILING MEDICINE CO., LTD. Free format text: FORMER OWNER: HEBEI YILING MEDICINE INST. CO., LTD. Effective date: 20080516 |
|
| C41 | Transfer of patent application or patent right or utility model | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20080516 Address after: No. 238 Tianshan Avenue, Shijiazhuang Patentee after: Shijiazhuang Yiling Pharmaceutical Co., Ltd. Address before: Xinshi North Road, Shijiazhuang Development Zone, Hebei Province, No. 385 Patentee before: Hebei Yiling Medicine Research Institute Co., Ltd. |