CN112206298A - Application of traditional Chinese medicine composition in preparation of medicine for treating diarrhea - Google Patents
Application of traditional Chinese medicine composition in preparation of medicine for treating diarrhea Download PDFInfo
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- CN112206298A CN112206298A CN201910552273.XA CN201910552273A CN112206298A CN 112206298 A CN112206298 A CN 112206298A CN 201910552273 A CN201910552273 A CN 201910552273A CN 112206298 A CN112206298 A CN 112206298A
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Abstract
The invention provides application of a traditional Chinese medicine composition in preparation of a medicine for treating diarrhea, wherein the medicine is prepared from the following raw materials in parts by weight: 130-390 parts of astragalus mongholicus, 105-315 parts of glossy privet fruit, 39-117 parts of ginseng, 40-120 parts of lucid ganoderma, 79-327 parts of curcuma zedoary, 157-473 parts of gynostemma pentaphylla, 40-120 parts of fried bighead atractylodes rhizome, 40-120 parts of poria cocos, 5-15 parts of cordyceps sinensis, 79-237 parts of paniculate swallowwort root, 40-120 parts of ground beetle, 13-39 parts of pseudo-ginseng, 79-237 parts of oldenlandia diffusa, 79-237 parts of barbed skullcap herb and 25-75 parts of fried medicated leaven. The invention can be used for treating diarrhea caused by tumor chemotherapy.
Description
Technical Field
The invention relates to a new application of a traditional Chinese medicine composition, in particular to an application of the traditional Chinese medicine composition in preparing a medicine for treating diarrhea.
Background
Diarrhea refers to frequent defecation obviously exceeding the frequency of ordinary daily habit, thin feces, increased water content, more than 200g of feces per day, or containing undigested food, bloody pus and mucus. Diarrhea is often accompanied by symptoms such as a sense of urgency, anal discomfort, incontinence, etc. About 9L of liquid enters the gastrointestinal tract of normal people every day, and the moisture is absorbed through the intestinal tract, so that the final moisture in the excrement is only about 100-200 ml. If the amount of fluid entering the colon exceeds the absorption capacity of the colon or/and the absorption capacity of the colon is reduced, this results in increased water excretion from the stool and diarrhea.
The traditional Chinese medicine considers that toxic and side effects caused by chemotherapy are caused by excessive toxic heat in vivo, damaged yin and body fluid, damaged qi and blood and deficiency of liver and kidney due to chemotherapy, and patients with tumors are old, weak and sick for many years, and the healthy qi is deficient, qi deficiency and yang deficiency, so that the constitution of deficiency-cold is common. After chemotherapy, the spleen and stomach are more weak, food is not dissolved, water dampness is generated internally, damp-heat evil toxin flows into the large intestine, and the clear and turbid functions of the small intestine are weakened. Chemotherapy is one of effective methods for treating tumors, but chemotherapy-induced diarrhea is increasingly common, and about 25% of chemotherapy patients experience acute or persistent diarrhea, which may be caused by acute injury of intestinal mucosa, reduced absorption of small intestine, increased secretion of intestinal juice, increased peristalsis of intestinal canal, diarrhea, opportunistic infection due to damage of barrier function and immune function of intestinal mucosa, and thus severe diarrhea after chemotherapy, persistent diarrhea, such as untimely effective treatment and control, electrolyte disturbance, malnutrition, dehydration, acute renal insufficiency, and even life threatening.
At present, the general treatment is to correct water, electrolyte and acid-base balance disorder and nutrition unbalance, supplement liquid as appropriate, supplement vitamins, amino acids, fat emulsion and other nutrients, and then carry out anti-infection treatment: according to different etiological factors, corresponding antibiotics are selected. Mucosa protective agent: dioctahedral smectites, sucralfate, etc. A microecological preparation: the Bifidobacterium can regulate intestinal flora. Antidiarrheal agents: the corresponding antidiarrheal agent is selected according to specific conditions. However, the above treatment methods only can temporarily relieve the symptoms of diarrhea, and do not fundamentally treat the diarrhea, so that a medicament for treating both symptoms and root causes and effectively treating the diarrhea is urgently needed.
Disclosure of Invention
The medicine has the effects of supplementing qi and nourishing yin, and strengthening spleen and tonifying kidney, and radically solves the problem of diarrhea caused by chemotherapy. The research shows that the medicine can effectively treat diarrhea caused by chemotherapy, has a good effect, and can improve the life quality of tumor patients.
The invention relates to a new application of a traditional Chinese medicine composition, in particular to an application of the traditional Chinese medicine composition in preparing a medicine for treating diarrhea.
The medicine for treating diarrhea is prepared from the following raw materials, by weight, 130-390 parts of astragalus membranaceus, 105-315 parts of glossy privet fruit, 39-117 parts of ginseng, 40-120 parts of lucid ganoderma, 79-327 parts of curcuma zedoary, 157-473 parts of gynostemma pentaphylla, 40-120 parts of fried bighead atractylodes rhizome, 40-120 parts of poria cocos, 5-15 parts of cordyceps sinensis, 79-237 parts of cynanchum paniculatum, 40-120 parts of ground beetle, 13-39 parts of pseudo-ginseng, 79-237 parts of oldenlandia diffusa, 79-237 parts of barbed skullcap herb and 25-75 parts of fried medicated leaven.
Preferably, the medicine is prepared from 260 parts of astragalus membranaceus, 210 parts of glossy privet fruit, 78 parts of ginseng, 80 parts of lucid ganoderma, 158 parts of curcuma zedoary, 315 parts of gynostemma pentaphylla, 80 parts of fried bighead atractylodes rhizome, 80 parts of poria cocos, 10 parts of cordyceps sinensis, 158 parts of paniculate swallowwort root, 80 parts of ground beeltle, 26 parts of pseudo-ginseng, 158 parts of oldenlandia diffusa, 158 parts of sculellaria barbata and 50 parts of fried medicated leaven.
The preferable medicine is prepared from the following raw material medicines, by weight, 130 parts of astragalus membranaceus, 315 parts of glossy privet fruit, 39 parts of ginseng, 120 parts of lucid ganoderma, 79 parts of curcuma zedoary, 473 parts of gynostemma pentaphylla, 40 parts of fried bighead atractylodes rhizome, 120 parts of poria cocos, 5 parts of cordyceps sinensis, 237 parts of paniculate swallowwort root, 40 parts of ground beeltle, 39 parts of pseudo-ginseng, 79 parts of oldenlandia diffusa, 237 parts of sculellaria barbata and 25 parts of fried medicated leaven.
The preferable medicine is prepared from 390 parts of astragalus membranaceus, 105 parts of glossy privet fruit, 117 parts of ginseng, 40 parts of lucid ganoderma, 327 parts of curcuma zedoary, 157 parts of gynostemma pentaphylla, 120 parts of fried bighead atractylodes rhizome, 40 parts of poria cocos, 15 parts of cordyceps sinensis, 79 parts of paniculate swallowwort root, 120 parts of ground beeltle, 13 parts of pseudo-ginseng, 237 parts of oldenlandia diffusa, 79 parts of barbed skullcap herb and 75 parts of fried medicated leaven.
The active ingredients of the traditional Chinese medicine composition are prepared by the following steps:
(1) weighing the traditional Chinese medicinal materials according to the weight proportion of the raw materials, and cleaning and selecting;
(2) pulverizing Ginseng radix, Cordyceps, and Notoginseng radix into fine powder, and sieving;
(3) decocting radix astragali, fructus Ligustri Lucidi, Ganoderma, Curcumae rhizoma, herba Gynostemmatis, parched Atractylodis rhizoma, Poria, radix Cynanchi Paniculati, Eupolyphaga Seu Steleophaga, herba Hedyotidis Diffusae, herba Scutellariae Barbatae, and parched Massa Medicata Fermentata with 5-12 times of water for two times (2 hr for the first time and 1 hr for the second time), mixing decoctions, filtering, concentrating the filtrate, drying, and pulverizing into dry extract powder;
(4) the fine powder obtained in the step (2) and the dry paste powder obtained in the step (3) jointly form the active ingredients of the traditional Chinese medicine composition.
The preparation formulation of the traditional Chinese medicine composition is capsules, tablets, powder, oral liquid, pills, tinctures, syrups, suppositories, gels, sprays or injections.
The capsule is prepared by the following steps:
(1) weighing the traditional Chinese medicinal materials according to the weight proportion of the raw materials, and cleaning and selecting;
(2) pulverizing Ginseng radix, Cordyceps, and Notoginseng radix into fine powder, and sieving;
(3) decocting radix astragali, fructus Ligustri Lucidi, Ganoderma, Curcumae rhizoma, herba Gynostemmatis, parched Atractylodis rhizoma, Poria, radix Cynanchi Paniculati, Eupolyphaga Seu Steleophaga, herba Hedyotidis Diffusae, herba Scutellariae Barbatae, and parched Massa Medicata Fermentata with 9 times of water twice (2 hr for the first time and 1 hr for the second time), mixing decoctions, filtering, concentrating the filtrate to relative density of 1.2-1.25 at 60 deg.C, drying, and pulverizing into fine powder;
(4) and (3) uniformly mixing the fine powder obtained in the step (2) and the crushed powder obtained in the step (3), and encapsulating to obtain the capsule.
Other dosage forms of the medicament are prepared by a conventional preparation method after weighing raw material medicaments in proportion, for example, a preparation process recorded in Vanbitsin traditional Chinese medicine pharmacy (1 st 12 months in 1997 of Shanghai science publishers) to prepare pharmaceutically acceptable conventional dosage forms.
In order to make the above dosage forms possible, pharmaceutically acceptable excipients, such as: fillers, disintegrants, lubricants, suspending agents, binders, sweeteners, flavoring agents, preservatives, bases, and the like. The filler comprises: starch, pregelatinized starch, lactose, mannitol, chitin, microcrystalline cellulose, sucrose, etc.; the disintegrating agent comprises: starch, pregelatinized starch, microcrystalline cellulose, sodium carboxymethyl starch, crospolyvinylpyrrolidone, low-substituted hydroxypropylcellulose, croscarmellose sodium, etc.; the lubricant comprises: magnesium stearate, sodium lauryl sulfate, talc, silica, and the like; the suspending agent comprises: polyvinylpyrrolidone, microcrystalline cellulose, sucrose, agar, hydroxypropyl methylcellulose, and the like; the adhesive comprises starch slurry, polyvinylpyrrolidone, hydroxypropyl methylcellulose, etc.; the sweetener comprises: saccharin sodium, aspartame, sucrose, sodium cyclamate, glycyrrhetinic acid, and the like; the flavoring agent comprises: sweeteners and various essences; the preservative comprises: parabens, benzoic acid, sodium benzoate, sorbic acid and its salts, benzalkonium bromide, chloroacetidine acetate, eucalyptus oil, etc.; the matrix comprises: PEG6000, PEG4000, insect wax, etc. In order to realize the traditional Chinese medicine pharmacy, other pharmaceutically acceptable auxiliary materials (auxiliary materials recorded in each dosage form in the 12 th month and 1 st edition of Shanghai science Press 1997) are required to be added when preparing the dosage forms.
Preferably, the diarrhea is diarrhea caused by tumor chemotherapy, and the tumor is preferably gastric cancer and/or lung cancer.
The pharmaceutical composition has the effects of supplementing qi and nourishing yin, strengthening spleen and tonifying kidney, and eliminating stagnation and dredging collaterals, is clinically used for treating diarrhea, and achieves good effect. The invention has reasonable compatibility, simple and easy operation, is a pure Chinese medicinal preparation, has small adverse reaction and can be used by patients for a long time.
Detailed Description
Example 1:
260g of astragalus membranaceus, 210g of glossy privet fruit, 78g of ginseng, 80g of lucid ganoderma, 80g of curcuma zedoary, 158g of gynostemma pentaphylla, 315g of fried bighead atractylodes rhizome, 80g of poria cocos, 10g of cordyceps sinensis, 158g of paniculate swallowwort root, 80g of ground beetle, 26g of pseudo-ginseng, 26g of spreading hedyotis herb, 158g of sculellaria barbata, 158g of fried medicated.
The preparation method comprises the following steps:
(1) weighing the traditional Chinese medicinal materials according to the prescription amount, and cleaning and selecting;
(2) respectively pulverizing Ginseng radix, Cordyceps, and Notoginseng radix into fine powder, and sieving;
(3) adding 9 times of water into astragalus, glossy privet fruit, lucid ganoderma, curcuma zedoary, gynostemma pentaphylla, fried bighead atractylodes rhizome, poria cocos, paniculate swallowwort root, ground beeltle, spreading hedyotis herb, barbed skullcap herb and fried medicated leaven, decocting for two times, decocting for 2 hours for the first time and 1 hour for the second time, merging decoction, filtering, concentrating filtrate until the relative density is 1.2-1.25 measured at 60 ℃, drying and crushing into fine powder;
(4) and (3) grinding the fine powder obtained in the step (2) and the fine powder obtained in the step (3), sieving and uniformly mixing, and preparing 1000 capsules. The clinical dosage of the capsule of the invention is 6 g/day.
Example 2:
130g of astragalus mongholicus, 315g of glossy privet fruit, 39g of ginseng, 120g of lucid ganoderma, 7g of curcuma zedoary, 7g of gynostemma pentaphylla, 473g of fried bighead atractylodes rhizome, 40g of poria cocos, 120g of cordyceps sinensis, 5g of cynanchum paniculatum, 237g of ground beetle, 40g of pseudo-ginseng, 39g of oldenlandia diffusa, 79g of sculellaria barbata, 237g
The preparation method comprises the following steps:
(1) weighing the traditional Chinese medicinal materials according to the prescription amount, and cleaning and selecting;
(2) respectively pulverizing Ginseng radix, Cordyceps, and Notoginseng radix into fine powder, and sieving;
(3) adding 5 times of water into astragalus, glossy privet fruit, lucid ganoderma, curcuma zedoary, gynostemma pentaphylla, fried bighead atractylodes rhizome, poria cocos, paniculate swallowwort root, ground beeltle, spreading hedyotis herb, barbed skullcap herb and fried medicated leaven, decocting twice, decocting for 2 hours for the first time and 1 hour for the second time, merging decoction, filtering, concentrating filtrate until the relative density is 1.2-1.25 measured at 60 ℃, drying and crushing into fine powder;
(4) and (3) grinding the fine powder obtained in the step (2) and the fine powder obtained in the step (3), sieving, uniformly mixing, and preparing 1000 tablets according to a conventional method.
Example 3:
390g of astragalus, glossy privet fruit 105g of ginseng 117g of glossy ganoderma 40g of zedoary turmeric 327g of gynostemma pentaphyllum 157g of fried bighead atractylodes rhizome 120g of poria cocos 40g of cordyceps sinensis 15g of paniculate swallowwort 79g of ground beetle 120g of pseudo-ginseng 13g of oldenlandia 237g of barbed skullcap herb 79g of fried medicated leaven 75g
The preparation method comprises the following steps:
(1) weighing the traditional Chinese medicinal materials according to the prescription amount, and cleaning and selecting;
(2) respectively pulverizing Ginseng radix, Cordyceps, and Notoginseng radix into fine powder, and sieving;
(3) adding 12 times of water into astragalus, glossy privet fruit, lucid ganoderma, curcuma zedoary, gynostemma pentaphylla, fried bighead atractylodes rhizome, poria cocos, paniculate swallowwort root, ground beeltle, spreading hedyotis herb, barbed skullcap herb and fried medicated leaven, decocting twice, decocting for 2 hours for the first time and 1 hour for the second time, merging decoction, filtering, concentrating filtrate until the relative density is 1.2-1.25 measured at 60 ℃, drying and crushing into fine powder;
(4) and (3) grinding the fine powder obtained in the step (2) and the fine powder obtained in the step (3), sieving, uniformly mixing, and preparing pills according to a conventional method.
To confirm the efficacy of the drug of the present invention in treating diarrhea, the following clinical trial studies were conducted using capsules prepared according to example 1 (hereinafter referred to as the drug of the present invention):
test example: experimental study on diarrhea caused by tumor chemotherapy
1 data and method
1.1 general data: 80 diarrhea patients of Ling Hospital oncology from 3 months to 6 months in 2017 are collected, and the patients are randomly divided into a treatment group and a control group according to a random number table method, wherein the treatment group comprises 40 patients, 26 men and 14 women, the age is 35-71 (49.81 +/-7.22) years, the course is 3-7 (3.10 +/-1.22) d, the gastric cancer patients comprise 12 patients, and the lung cancer patients comprise 8 patients. 40 control cases, 25 male cases, 15 female cases, age 33-78 (50.18 + -6.93) years, disease course 3-6 (3.26 + -1.05) d, 10 stomach cancer patients, and 9 lung cancer patients. The general data of two groups of patients are compared, and the differences have no statistical significance (P is more than 0.05) in the aspects of sex, age, disease course, diarrhea degree and general symptoms and are comparable.
1.2 diagnostic criteria and Inclusion cases
Firstly, according to the diagnosis and treatment standard of the traditional Chinese medicine symptoms and the diarrhea standard in the traditional Chinese medicine internal science, secondly, all cases are pathologically diagnosed as malignant tumors, thirdly, the stool characters and the defecation times before chemotherapy are normal, and diarrhea symptoms appear in the chemotherapy process or after the cycle is over. Fourthly, the diarrhea is divided into three stages, the I-stage defecation frequency is 3-4 times/d more than before treatment, the II-stage defecation frequency is 5-7 times/d more than before treatment, the abdominal pain is accompanied, the III-stage defecation frequency is increased to more than 7 times, and the abdominal pain is accompanied by bloody stool; sixthly, diseases such as acute gastroenteritis and bacillary dysentery are eliminated, and the syndrome differentiation and classification of the traditional Chinese medicine are diarrhea with syndrome of cold-heat complication, which are mainly manifested by diarrhea and abdominal pain, burning sensation in anus, tenesmus, mental fatigue and hypodynamia, aversion to cold, cold limbs, inappetence, nausea and vomiting, pale tongue with white fur, soft and rapid pulse and the like.
1.3 methods of treatment
All patients are treated by selecting appropriate chemotherapy drugs according to the National Comprehensive Cancer Network (NCCN) guidelines of the United states according to the types of malignant tumors, and then orally taking Cimpan 1 bag each time and 3 times a day, the drug of the invention is added on the basis of a control group in a treatment group, the dose is 3 times a day, 2 capsules each time, and 7 days are taken as 1 treatment course in both groups.
1.4 therapeutic efficacy criteria
According to the standard of the traditional Chinese medicine disease diagnosis curative effect, the normal stool, the disappearance of other symptoms and the normal clinical examination are cured; the improvement is that the stool frequency is obviously reduced, other symptoms are improved, and the ineffectiveness is that the symptoms are not obviously improved or aggravated.
1.5 statistical methods
SPSS10.0 statistical analysis software was used for processing. The measured data are expressed by mean + -standard deviation, the comparison between groups adopts t test, and the comparison between counting data groups adopts chi2And (4) testing, comparing the grade data groups by Ridit analysis, and taking P less than 0.05 as the difference to have statistical significance.
2, results: the experimental study finds that the cure rate of a treatment group is as high as 30% and far higher than 5% of a control group, the ineffective rate of the treatment group is 5% and far lower than 32.5% of the control group, the effective rate of the treatment group is 95% and obviously higher than 67.5% of the control group, the two groups have statistical significance (P is less than 0.05), the medicine combined with the Simmadia can effectively treat diarrhea caused by tumor chemotherapy, the effect of treating the diarrhea caused by the tumor chemotherapy is obviously better than that of singly using the Simmadia, and the specific test result is shown in Table 3.
Table 3: two groups of observation results of therapeutic effect of diarrhea caused by tumor chemotherapy (%)
| Group of | n | Cure of disease | Improvement of life | Invalidation | High efficiency |
| Control group | 40 | 2（5.0%） | 25（62.5%） | 13（32.5%） | 67.5% |
| Treatment group | 40 | 12（30.0%） | 26（65.0%） | 2（5.0%） | 95.0% |
Claims (10)
1. The application of a traditional Chinese medicine composition in preparing a medicine for treating diarrhea is characterized in that the medicine is prepared from the following raw materials in parts by weight: 130-390 parts of astragalus mongholicus, 105-315 parts of glossy privet fruit, 39-117 parts of ginseng, 40-120 parts of lucid ganoderma, 79-327 parts of curcuma zedoary, 157-473 parts of gynostemma pentaphylla, 40-120 parts of fried bighead atractylodes rhizome, 40-120 parts of poria cocos, 5-15 parts of cordyceps sinensis, 79-237 parts of paniculate swallowwort root, 40-120 parts of ground beetle, 13-39 parts of pseudo-ginseng, 79-237 parts of oldenlandia diffusa, 79-237 parts of barbed skullcap herb and 25-75 parts of fried medicated leaven.
2. The application of claim 1, wherein the medicament is prepared from the following raw material medicines, by weight, 260 parts of astragalus membranaceus, 210 parts of glossy privet fruit, 78 parts of ginseng, 80 parts of lucid ganoderma, 158 parts of curcuma zedoary, 315 parts of gynostemma pentaphylla, 80 parts of fried bighead atractylodes rhizome, 80 parts of poria cocos, 10 parts of cordyceps sinensis, 158 parts of paniculate swallowwort root, 80 parts of ground beetle, 26 parts of pseudo-ginseng, 158 parts of spreading hedyotis herb, 158 parts of barbed skullcap herb and 50 parts of fried medicated leaven.
3. The application of claim 1, wherein the medicament is prepared from the following raw materials, by weight, 130 parts of astragalus membranaceus, 315 parts of glossy privet fruit, 39 parts of ginseng, 120 parts of lucid ganoderma, 79 parts of curcuma zedoary, 473 parts of gynostemma pentaphylla, 40 parts of fried bighead atractylodes rhizome, 120 parts of poria cocos, 5 parts of cordyceps sinensis, 237 parts of paniculate swallowwort root, 40 parts of ground beetle, 39 parts of pseudo-ginseng, 79 parts of spreading hedyotis herb, 237 parts of barbed skullcap herb and 25 parts of fried medicated leaven.
4. The application of claim 1, wherein the medicament is prepared from 390 parts of astragalus root, 105 parts of ligustrum japonicum, 117 parts of ginseng, 40 parts of ganoderma lucidum, 327 parts of curcuma zedoary, 157 parts of gynostemma pentaphylla, 120 parts of fried bighead atractylodes rhizome, 40 parts of poria cocos, 15 parts of cordyceps sinensis, 79 parts of paniculate swallowwort root, 120 parts of ground beetle, 13 parts of pseudo-ginseng, 237 parts of oldenlandia diffusa, 79 parts of sculellaria barbata and 75 parts of fried medicated leaven.
5. The use according to any one of claims 1 to 4, characterized in that the active ingredients of the Chinese medicinal composition are prepared by the following steps:
(1) weighing the traditional Chinese medicinal materials according to the weight proportion of the raw materials, and cleaning and selecting;
(2) pulverizing Ginseng radix, Cordyceps, and Notoginseng radix into fine powder, and sieving;
decocting radix astragali, fructus Ligustri Lucidi, Ganoderma, Curcumae rhizoma, herba Gynostemmatis, parched Atractylodis rhizoma, Poria, radix Cynanchi Paniculati, Eupolyphaga Seu Steleophaga, herba Hedyotidis Diffusae, herba Scutellariae Barbatae, and parched Massa Medicata Fermentata with 5-12 times of water for two times (2 hr for the first time and 1 hr for the second time), mixing decoctions, filtering, concentrating the filtrate, drying, and pulverizing into dry extract powder;
the fine powder obtained in the step (2) and the dry paste powder obtained in the step (3) jointly form the active ingredients of the traditional Chinese medicine composition.
6. The use according to any one of claims 1 to 4, wherein the formulation of the Chinese medicinal composition is in the form of capsules, tablets, powders, oral liquids, pills, tinctures, syrups, suppositories, gels, sprays or injections.
7. The use according to claim 6, characterized in that the capsules are made by the following steps:
(1) weighing the traditional Chinese medicinal materials according to the weight proportion of the raw materials, and cleaning and selecting;
(2) pulverizing Ginseng radix, Cordyceps, and Notoginseng radix into fine powder, and sieving;
(3) decocting radix astragali, fructus Ligustri Lucidi, Ganoderma, Curcumae rhizoma, herba Gynostemmatis, parched Atractylodis rhizoma, Poria, radix Cynanchi Paniculati, Eupolyphaga Seu Steleophaga, herba Hedyotidis Diffusae, herba Scutellariae Barbatae, and parched Massa Medicata Fermentata with 9 times of water twice (2 hr for the first time and 1 hr for the second time), mixing decoctions, filtering, concentrating the filtrate to relative density of 1.2-1.25 at 60 deg.C, drying, and pulverizing into fine powder;
(4) and (3) uniformly mixing the fine powder obtained in the step (2) and the crushed powder obtained in the step (3), and encapsulating to obtain the capsule.
8. The use according to any one of claims 1 to 4, wherein the diarrhea is tumor chemotherapy-induced diarrhea.
9. The use according to claim 8, wherein the tumor is gastric cancer.
10. The use of claim 8, wherein the tumor is lung cancer.
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