CN107184651B - Traditional Chinese medicine composition for clearing away heat and toxic materials and preparation method and application thereof - Google Patents
Traditional Chinese medicine composition for clearing away heat and toxic materials and preparation method and application thereof Download PDFInfo
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- CN107184651B CN107184651B CN201710439965.4A CN201710439965A CN107184651B CN 107184651 B CN107184651 B CN 107184651B CN 201710439965 A CN201710439965 A CN 201710439965A CN 107184651 B CN107184651 B CN 107184651B
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- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 210000000582 semen Anatomy 0.000 description 1
- 239000009254 shuang-huang-lian Substances 0.000 description 1
- HRZFUMHJMZEROT-UHFFFAOYSA-L sodium disulfite Chemical compound [Na+].[Na+].[O-]S(=O)S([O-])(=O)=O HRZFUMHJMZEROT-UHFFFAOYSA-L 0.000 description 1
- 235000010267 sodium hydrogen sulphite Nutrition 0.000 description 1
- 239000001540 sodium lactate Substances 0.000 description 1
- 229940005581 sodium lactate Drugs 0.000 description 1
- 235000011088 sodium lactate Nutrition 0.000 description 1
- 229940001584 sodium metabisulfite Drugs 0.000 description 1
- 235000010262 sodium metabisulphite Nutrition 0.000 description 1
- AKHNMLFCWUSKQB-UHFFFAOYSA-L sodium thiosulfate Chemical compound [Na+].[Na+].[O-]S([O-])(=O)=S AKHNMLFCWUSKQB-UHFFFAOYSA-L 0.000 description 1
- 235000019345 sodium thiosulphate Nutrition 0.000 description 1
- 239000000600 sorbitol Substances 0.000 description 1
- 235000010356 sorbitol Nutrition 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 239000005720 sucrose Substances 0.000 description 1
- 239000004094 surface-active agent Substances 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 239000000454 talc Substances 0.000 description 1
- 229910052623 talc Inorganic materials 0.000 description 1
- 235000012222 talc Nutrition 0.000 description 1
- 238000012360 testing method Methods 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000397 ulcer Toxicity 0.000 description 1
- 238000001291 vacuum drying Methods 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 230000009385 viral infection Effects 0.000 description 1
- 235000019154 vitamin C Nutrition 0.000 description 1
- 239000011718 vitamin C Substances 0.000 description 1
- 239000000811 xylitol Substances 0.000 description 1
- 235000010447 xylitol Nutrition 0.000 description 1
- HEBKCHPVOIAQTA-SCDXWVJYSA-N xylitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)CO HEBKCHPVOIAQTA-SCDXWVJYSA-N 0.000 description 1
- 229960002675 xylitol Drugs 0.000 description 1
- 239000009916 yin-huang Substances 0.000 description 1
- 239000009792 yinqiao Substances 0.000 description 1
- UHVMMEOXYDMDKI-JKYCWFKZSA-L zinc;1-(5-cyanopyridin-2-yl)-3-[(1s,2s)-2-(6-fluoro-2-hydroxy-3-propanoylphenyl)cyclopropyl]urea;diacetate Chemical compound [Zn+2].CC([O-])=O.CC([O-])=O.CCC(=O)C1=CC=C(F)C([C@H]2[C@H](C2)NC(=O)NC=2N=CC(=CC=2)C#N)=C1O UHVMMEOXYDMDKI-JKYCWFKZSA-L 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/539—Scutellaria (skullcap)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/19—Acanthaceae (Acanthus family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/536—Prunella or Brunella (selfheal)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation or decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
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Abstract
The invention relates to a traditional Chinese medicine composition for clearing away heat and toxic materials, a preparation method and application thereof, wherein the traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 5-15 parts of scutellaria baicalensis, 15-25 parts of common andrographis herb and 1-6 parts of selfheal. The preparation method comprises the following steps: (1) mixing the raw materials in proportion, and pulverizing half of the raw materials into fine powder; (2) decocting the rest materials in water twice, filtering, concentrating the filtrate, adding adjuvants and fine powder, and mixing to obtain mixture; (3) drying, pulverizing, granulating, tabletting, and sugar coating. The method has the advantages that: 1. the traditional Chinese medicine composition only has three medicines, has few medicines, simple preparation method and low treatment cost, and has good heat-clearing and detoxifying effects; 2. the traditional Chinese medicine composition has wide application range and obvious curative effects on lymph node swelling and pain, oral ulcer, gingival swelling and pain, dry stool, bacillary dysentery and the like.
Description
Technical Field
The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for clearing away heat and toxic materials, and a preparation method and application thereof.
Background
Bacteria and viruses are main pathogens of upper respiratory tract infection and lung infection, are enemies which are struggled by human from beginning to date, and have main symptoms of high fever, slight aversion to wind, running nose, cough, sore throat, floating pulse and the like. According to statistics, the death caused by fever and lung infection is at least more than 200 ten thousand every year all over the world, and the health of people is seriously influenced. With the widespread use of antibiotics, modern medicine can largely inhibit bacterial infections, but there is still a lack of good therapeutic methods and drugs for viral infections. Worrying about that the treatment effect of antibiotics is greatly reduced due to the serious toxic and side effects caused by the abuse of the antibiotics and the appearance of a large number of drug-resistant strains, so that the continuous research and development of novel antibiotics are forced, the research and development investment is huge, the drugs are expensive, and the patients and the society bear heavy economic burden. The traditional Chinese medicine has the advantages of better curative effect, low price and less adverse reaction on respiratory tract infection caused by bacteria and viruses compared with western medicine.
The traditional Chinese medicines for clearing away heat and toxic materials have various varieties, most of the traditional Chinese medicines have the effects of resisting bacteria, viruses, fever and inflammation, the commonly used traditional Chinese medicines comprise honeysuckle, scutellaria baicalensis, forsythia, houttuynia cordata, radix bupleuri and the like, the commonly used traditional Chinese medicine preparation comprises Shuanghuanglian granules and oral liquid prepared from honeysuckle, scutellaria baicalensis and forsythia, and Yinhuang buccal tablets and granules prepared from honeysuckle extracts and scutellaria baicalensis extracts, and isatis root granules, Yinqiao tablets and the like, and the traditional Chinese medicine preparation has better curative effect and is widely applied clinically. The Chinese medicinal formula which is the closest to the invention by search comprises the following components: (1) chinese patent 201410191213.7 discloses a Chinese medicinal composition for treating sore throat, which comprises the following raw materials in parts by weight: 7.5-9.5 parts of cimicifugae foetidae, 10-12 parts of lophatherum gracile, 5-7 parts of semen lepidii, 3-5 parts of medicinal cyathula root, 2-4 parts of scutellaria baicalensis, 1-3 parts of cotton rose hibiscus leaf, 3-5 parts of curcuma aromatica, 2-4 parts of philippine violet herb, 4-6 parts of emblic leafflower fruit, 5-7 parts of prepared rehmannia root, 3-5 parts of common andrographis herb, 2-4 parts of vietnamese sophora root, 5-8 parts of honey-fried licorice root, 4-6 parts of isatis root, 2-4 parts of selfheal, 2-4 parts of fern rhizome, 1-3 parts of mallow-leaved lemongrass, 2; the Chinese medicinal composition has effects of promoting blood circulation, eliminating phlegm, clearing away heat and toxic materials, relieving swelling, and improving disease resistance. (2) Chinese patent 2006101140207 discloses a Chinese medicine for clearing heat and removing toxicity, which is prepared from the following Chinese medicinal raw materials: 2.5-10g of artificial bezoar, 50-400g of rhubarb, 75-300g of scutellaria baicalensis, 75-300g of rhizoma anemarrhenae, 50-200g of buffalo horn, 50-200g of wild chrysanthemum flower, 50-200g of platycodon grandiflorum and 25-100g of liquorice. (3) Chinese patent 200510004852.9 discloses a Chinese medicinal preparation for clearing away heat and toxic materials and its preparation method, wherein the Chinese medicinal preparation is prepared from bupleuri radix, Scutellariae radix, rhizoma Belamcandae and one or more of the following raw materials: honeysuckle, forsythia, gardenia, figwort, wild chrysanthemum and giant knotweed, wherein in every 1000 unit doses of the preparation, the raw materials are as follows by weight: 1500-6000 parts of radix bupleuri, 1500-6000 parts of radix scutellariae and 1250-5000 parts of blackberrykiky rhizome; 1500-6000 parts of honeysuckle, 1500-6000 parts of fructus forsythiae, 1500-6000 parts of cape jasmine, 1750-7000 parts of wild chrysanthemum flower, 1750-7000 parts of radix scrophulariae and 1750-7000 parts of giant knotweed rhizome. The traditional Chinese medicine composition has the following defects: the medicine has many medicines, the application range is narrow, the preparation method of the medicine is complex, and the curative effect is difficult to determine.
Disclosure of Invention
The first purpose of the present invention is to provide a Chinese medicine composition for clearing away heat and toxic material.
The second purpose of the present invention is to provide the pharmaceutical use of the above-mentioned Chinese medicinal composition for overcoming the disadvantages of the prior art.
The third objective of the present invention is to provide a method for preparing the above-mentioned Chinese medicinal composition, aiming at the disadvantages of the prior art.
In order to achieve the first purpose, the invention adopts the technical scheme that:
a traditional Chinese medicine composition for clearing away heat and toxic materials is prepared from the following raw material medicines in parts by weight: 5-15 parts of scutellaria baicalensis, 15-25 parts of common andrographis herb and 1-6 parts of selfheal.
Further, the traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 8-12 parts of scutellaria baicalensis, 18-22 parts of common andrographis herb and 2-4 parts of selfheal.
Further, the traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 10 parts of scutellaria baicalensis, 20 parts of common andrographis herb and 3 parts of common selfheal fruit-spike.
In order to achieve the second object, the invention adopts the technical scheme that:
the application of the traditional Chinese medicine composition in preparing the medicine for treating bacillary dysentery.
The application of the traditional Chinese medicine composition in preparing the medicine for treating the dental ulcer.
Furthermore, the medicament can be prepared into tablets, capsules, oral liquid, granules, pills, powder, paste, pellets, suspensions, solutions, suppositories or patches.
Further, the medicament also comprises pharmaceutically acceptable auxiliary materials, and the pharmaceutically acceptable auxiliary materials comprise but are not limited to: mannitol, sorbitol, sodium metabisulfite, sodium bisulfite, sodium thiosulfate, cysteine hydrochloride, thioglycolic acid, methionine, vitamin C, EDTA disodium, sodium calcium EDTA, monovalent alkali metal carbonates, acetates, phosphates or aqueous solutions thereof, hydrochloric acid, acetic acid, sulfuric acid, phosphoric acid, amino acids, sodium chloride, potassium chloride, sodium lactate, xylitol, maltose, glucose, fructose, dextran, glycine, starch, sucrose, lactose, brown sugar, mannitol, silicon derivatives, cellulose and derivatives thereof, alginates, gelatin, polyvinylpyrrolidone, glycerol, Tween 80, agar, calcium carbonate, calcium bicarbonate, surfactants, polyethylene glycol, cyclodextrin, beta-cyclodextrin, phospholipid-like materials, kaolin, talc, calcium stearate, magnesium stearate.
In order to achieve the third object, the invention adopts the technical scheme that:
the preparation method of the medicine comprises the following steps:
(1) mixing the raw materials in proportion, and pulverizing half of the raw materials into fine powder;
(2) decocting the rest materials in water twice, filtering, concentrating the filtrate, adding adjuvants and fine powder, and mixing to obtain mixture;
(3) drying, pulverizing, granulating, tabletting, and sugar coating.
Further, the auxiliary material is brown sugar.
The invention has the advantages that:
1. the traditional Chinese medicine composition provided by the invention only comprises three medicines, the number of the medicines is small, the preparation method is simple, the treatment cost is low, and the traditional Chinese medicine composition has a good heat-clearing and detoxifying effect.
2. In the traditional Chinese medicine composition, the selfheal is added to play a role in synergy, so that the heat-clearing and detoxifying effects are obviously improved.
3. In the traditional Chinese medicine composition, the proportion of the three medicines is screened by tests, and the traditional Chinese medicine composition has the advantage of remarkable effect.
4. The traditional Chinese medicine composition has wide application range and obvious curative effects on lymph node swelling and pain, oral ulcer, gingival swelling and pain, dry stool, bacillary dysentery and the like.
Detailed Description
The invention will be further illustrated with reference to specific embodiments. It should be understood that these examples are for illustrative purposes only and are not intended to limit the scope of the present invention. Furthermore, it should be understood that various changes and modifications can be made by those skilled in the art after reading the disclosure of the present invention, and equivalents fall within the scope of the appended claims.
EXAMPLE 1 Heat-clearing and detoxicating Chinese medicinal composition
10 parts of scutellaria baicalensis, 20 parts of common andrographis herb and 3 parts of common selfheal fruit-spike.
EXAMPLE 2 Heat-clearing and detoxicating Chinese medicinal composition (II)
15 parts of scutellaria baicalensis, 15 parts of common andrographis herb and 6 parts of selfheal spike.
EXAMPLE 3 Heat-clearing and detoxicating Chinese medicinal composition (III)
5 parts of scutellaria baicalensis, 25 parts of common andrographis herb and 1 part of selfheal.
EXAMPLE 4 Heat-clearing and detoxicating Chinese medicinal composition (IV)
5 parts of scutellaria baicalensis, 15 parts of common andrographis herb and 1 part of selfheal.
Example 5 Chinese medicinal composition for clearing away Heat and toxic materials (V)
15 parts of scutellaria baicalensis, 15 parts of common andrographis herb and 1 part of selfheal.
Example 6 Chinese medicinal composition for clearing away Heat and toxic materials
15 parts of scutellaria baicalensis, 25 parts of common andrographis herb and 1 part of selfheal.
Example 7 preparation of a pharmaceutical decoction for clearing away Heat and toxic materials
The traditional Chinese medicine composition in the embodiment 1-6 is uniformly mixed, and the raw materials are decocted by adding water into the traditional Chinese medicine decoction according to a conventional preparation method of the traditional Chinese medicine decoction.
EXAMPLE 8 preparation of a Heat-clearing and detoxicating medicine
(1) 1000g of scutellaria baicalensis, 2000g of common andrographis herb and 300g of selfheal spike;
(2) taking raw material medicines according to a certain proportion, and crushing 500g of scutellaria baicalensis, 1000g of common andrographis herb and 150g of selfheal into fine powder;
(3) decocting the rest materials in water twice, filtering, concentrating the filtrate to 400ml, adding 500g brown sugar and the above fine powder, mixing, oven drying at 60-80 deg.C, pulverizing, granulating, sieving with No. two sieve, tabletting, and coating with sugar (each tablet weight is about 0.3 g).
EXAMPLE 9 preparation of a Heat-clearing and detoxicating medicine
(1) 1500g of scutellaria baicalensis, 1500g of andrographis paniculata and 600g of selfheal;
(2) taking raw material medicines according to a certain proportion, and crushing 750g of scutellaria baicalensis, 750g of andrographis paniculata and 300g of selfheal into fine powder;
(3) decocting the rest materials in water twice, filtering, concentrating the filtrate to 400ml, adding 500g brown sugar and the above fine powder, mixing, oven drying at 60-80 deg.C, pulverizing, granulating, sieving with No. two sieve, tabletting, and coating with sugar (each tablet weight is about 0.3 g).
EXAMPLE 10 preparation of a Heat-clearing and detoxicating medicine
(1) 500g of scutellaria baicalensis, 2500g of common andrographis herb and 100g of selfheal spike;
(2) taking raw material medicines according to a certain proportion, and crushing 250g of scutellaria baicalensis, 1250g of common andrographis herb and 50g of selfheal into fine powder;
(3) decocting the rest materials in water twice, filtering, concentrating the filtrate to 400ml, adding 500g brown sugar and the above fine powder, mixing, oven drying at 60-80 deg.C, pulverizing, granulating, sieving with No. two sieve, tabletting, and coating with sugar (each tablet weight is about 0.3 g).
EXAMPLE 11 preparation of a Heat-clearing and detoxicating medicine (IV)
(1) 500g of scutellaria baicalensis, 1500g of common andrographis herb and 100g of selfheal spike;
(2) taking raw material medicines according to a certain proportion, and crushing 250g of scutellaria baicalensis, 750g of andrographis paniculata and 50g of selfheal into fine powder;
(3) decocting the rest materials in water twice, filtering, concentrating the filtrate to 400ml, adding 500g brown sugar and the above fine powder, mixing, oven drying at 60-80 deg.C, pulverizing, granulating, sieving with No. two sieve, tabletting, and coating with sugar (each tablet weight is about 0.3 g).
EXAMPLE 12 preparation of a Heat-clearing and detoxicating medicine (V)
(1) 1500g of scutellaria baicalensis, 1500g of andrographis paniculata and 100g of selfheal;
(2) taking raw material medicines according to a certain proportion, and crushing 750g of scutellaria baicalensis, 750g of andrographis paniculata and 50g of selfheal into fine powder;
(3) decocting the rest materials in water twice, filtering, concentrating the filtrate to 400ml, adding 500g brown sugar and the above fine powder, mixing, oven drying at 60-80 deg.C, pulverizing, granulating, sieving with No. two sieve, tabletting, and coating with sugar (each tablet weight is about 0.3 g).
EXAMPLE 13 preparation of a Heat-clearing and detoxicating medicine (VI)
(1) 1500g of scutellaria baicalensis, 2500g of common andrographis herb and 100g of selfheal spike;
(2) taking raw material medicines according to a certain proportion, and crushing 750g of scutellaria baicalensis, 1250g of common andrographis herb and 50g of selfheal into fine powder;
(3) decocting the rest materials in water twice, filtering, concentrating the filtrate to 400ml, adding 500g brown sugar and the above fine powder, mixing, oven drying at 60-80 deg.C, pulverizing, granulating, sieving with No. two sieve, tabletting, and coating with sugar (each tablet weight is about 0.3 g).
EXAMPLE 14 preparation of a medicament for clearing away Heat and toxic materials (seven)
(1) 1500g of scutellaria baicalensis, 2500g of common andrographis herb and 600g of selfheal spike;
(2) taking raw material medicines according to a certain proportion, and crushing 750g of scutellaria baicalensis, 1250g of common andrographis herb and 300g of selfheal into fine powder;
(3) decocting the rest materials in water twice, filtering, concentrating the filtrate to 400ml, adding 500g brown sugar and the above fine powder, mixing, oven drying at 60-80 deg.C, pulverizing, granulating, sieving with No. two sieve, tabletting, and coating with sugar (each tablet weight is about 0.3 g).
EXAMPLE 15 preparation of a medicine for clearing away Heat and toxic Material (eight)
(1) 1200g of scutellaria baicalensis, 2200g of common andrographis herb and 400g of common selfheal fruit-spike;
(2) taking raw material medicines according to a certain proportion, and crushing 600g of scutellaria baicalensis, 1100g of common andrographis herb and 200g of selfheal into fine powder;
(3) decocting the rest materials in water twice, filtering, concentrating the filtrate to 400ml, adding 500g brown sugar and the above fine powder, mixing, oven drying at 60-80 deg.C, pulverizing, granulating, sieving with No. two sieve, tabletting, and coating with sugar (each tablet weight is about 0.3 g).
EXAMPLE 16 preparation of Heat-clearing and detoxifying drug capsules
(1) 1000g of scutellaria baicalensis, 2000g of common andrographis herb and 300g of selfheal spike;
(2) taking raw material medicines according to a certain proportion, and crushing 500g of scutellaria baicalensis, 1000g of common andrographis herb and 150g of selfheal into fine powder;
(3) decocting the rest materials in water twice, filtering, concentrating the filtrate to 400ml, adding the above fine powder, mixing, adding pharmaceutical adjuvants, vacuum drying, pulverizing, granulating, and making into tablet or capsule.
EXAMPLE 17 preparation of Heat-clearing and antidote drug particles
(1) 1000g of scutellaria baicalensis, 2000g of common andrographis herb and 300g of selfheal spike;
(2) taking raw material medicines according to a certain proportion, and crushing 500g of scutellaria baicalensis, 1000g of common andrographis herb and 150g of selfheal into fine powder;
(3) decocting the rest materials in water twice, filtering, concentrating the filtrate to 400ml, adding the above fine powder, mixing, adding appropriate pharmaceutical adjuvants, granulating, drying, grading to obtain 20g granule, and packaging into 10g bags.
Example 18 preparation of Heat clearing and toxicity removing pharmaceutical composition/oral liquid/syrup
(1) 1000g of scutellaria baicalensis, 2000g of common andrographis herb and 300g of selfheal spike;
(2) taking raw material medicines according to a certain proportion, and crushing 500g of scutellaria baicalensis, 1000g of common andrographis herb and 150g of selfheal into fine powder;
(3) decocting the rest materials in water twice, filtering, concentrating the filtrate to 400ml, adding the above fine powder, mixing, adding appropriate pharmaceutical adjuvants, and making into mixture, oral liquid or syrup.
Example 19 Heat-clearing and detoxifying animal experiment
First, detoxication action
1. Method of producing a composite material
The body temperature of clean male SD rats is measured for 3 days before the experiment, animals with the body temperature change not more than 0.3 ℃ are screened for the experiment, the experimental rats are randomly divided into nine groups, 0.1ml of 1% carrageenan solution is injected under the right hind limb soles of the rats immediately after the stomach filling administration, the foot volumes of the rats before and 1-6h after the inflammation is caused are recorded, and the swelling rate is calculated.
2. Administration of drugs
1 group of traditional Chinese medicines: administering a traditional Chinese medicine decoction prepared from the traditional Chinese medicine composition (10 parts of scutellaria baicalensis, 20 parts of common andrographis herb and 3 parts of selfheal) in the embodiment 1 of the invention, and performing intragastric administration according to the crude drug amount of 6.6 g/kg;
and (3) traditional Chinese medicine 2 groups: administering the traditional Chinese medicine decoction prepared in the embodiment 2 (15 parts of scutellaria baicalensis, 15 parts of common andrographis herb and 6 parts of common selfheal fruit-spike), and performing intragastric administration according to the crude drug amount of 6.6 g/kg;
3 groups of traditional Chinese medicines: administering the traditional Chinese medicine decoction prepared in the embodiment 3 (5 parts of scutellaria baicalensis, 25 parts of common andrographis herb and 1 part of selfheal), and performing intragastric administration according to the crude drug amount of 6.6 g/kg;
4 groups of traditional Chinese medicines: administering Chinese medicinal decoction of Chinese medicinal composition (Scutellariae radix 20 parts, herba Andrographitis 10 parts, and Prunellae Spica 3 parts) according to crude drug amount of 6.6 g/kg;
5 groups of traditional Chinese medicines: administering Chinese medicinal decoction prepared from Chinese medicinal composition (10 parts of Scutellariae radix and 20 parts of herba Andrographitis) according to crude drug amount of 6.6 g/kg;
6 groups of traditional Chinese medicines: administering Chinese medicinal decoction of Chinese medicinal composition (10 parts of Scutellariae radix, 20 parts of herba Andrographitis, 3 parts of Prunellae Spica, and 10 parts of flos Lonicerae) according to crude drug amount of 6.6 g/kg;
7 groups of traditional Chinese medicines: administering Chinese medicinal decoction of Chinese medicinal composition (10 parts of Scutellariae radix, 20 parts of herba Andrographitis, 3 parts of Prunellae Spica, and 10 parts of fructus forsythiae) according to crude drug amount of 6.6 g/kg;
8 groups of traditional Chinese medicines: administering Chinese medicinal decoction of Chinese medicinal composition (10 parts of Scutellariae radix, 20 parts of herba Andrographitis, 3 parts of Prunellae Spica, and 10 parts of herba Houttuyniae) according to crude drug amount of 6.6 g/kg;
the blank control group was gavaged with an equal amount of physiological saline.
3. Results
TABLE 1 Effect of the groups on the rate of swelling of the foot after administration
Note: p <0.05, P <0.01, compared to control group
The results show that: compared with a blank control group, the swelling rates of the Chinese medicine 1 group, the Chinese medicine 2 group and the Chinese medicine 3 group are all reduced, and the significant differences (P <0.05 and P <0.01) show that the Chinese medicine composition can significantly inhibit the volume of the swollen soles of rats and has the effects of inhibiting bacteria and removing toxicity. Compared with the traditional Chinese medicines 2-4, the traditional Chinese medicine 1 group has the best effect under the condition of the same dosage, which shows that the detoxification effect is the best when the ratio of the scutellaria baicalensis, the andrographis paniculata and the selfheal is 10:20: 3. Compared with the traditional Chinese medicine 5 group, the traditional Chinese medicine 1 group has the best effect under the condition of the same dosage, which shows that the selfheal added in the prescription plays a role of synergy and obviously improves the detoxification effect of the prescription. Compared with the traditional Chinese medicines 6-8, the traditional Chinese medicine 1 group has the best effect under the condition of the same dosage, which indicates that the detoxification effect cannot be improved by adding other commonly used heat-clearing and detoxifying medicines in the prescription, so the prescription of the invention has the advantages of less medicine taste and good curative effect.
Second, clearing away Heat
1. Method of producing a composite material
Selecting big ear white rabbit with weight of 2-3kg, and screening animal with body temperature of 38-39.4 deg.C and body temperature change of no more than 0.4 deg.C before experiment. Basal body temperature was measured on the day of the experiment, and a normal saline solution of bacterial endotoxin was injected into the ear vein of rabbit at a dose of 1ml/kg and 10 ml. Measuring body temperature every 1 hr, randomly dividing rabbits with body temperature higher than 0.5 deg.C into 9 groups, measuring body temperature every 1 hr after intragastric administration, and calculating the difference value with basal body temperature.
2. Administration of drugs
1 group of traditional Chinese medicines: the traditional Chinese medicine decoction prepared in the embodiment 1 (10 parts of scutellaria baicalensis, 20 parts of common andrographis herb and 3 parts of common selfheal fruit-spike) is administrated by stomach irrigation according to the crude drug amount of 6.6 g/kg;
and (3) traditional Chinese medicine 2 groups: administering the traditional Chinese medicine decoction prepared in the embodiment 2 (15 parts of scutellaria baicalensis, 15 parts of common andrographis herb and 6 parts of common selfheal fruit-spike), and performing intragastric administration according to the crude drug amount of 6.6 g/kg;
3 groups of traditional Chinese medicines: administering the traditional Chinese medicine decoction prepared in the embodiment 3 (5 parts of scutellaria baicalensis, 25 parts of common andrographis herb and 1 part of selfheal), and performing intragastric administration according to the crude drug amount of 6.6 g/kg;
4 groups of traditional Chinese medicines: administering Chinese medicinal decoction prepared from Chinese medicinal composition (Scutellariae radix 20 parts, herba Andrographitis 10 parts, and Prunellae Spica 3 parts), and performing intragastric administration according to crude drug amount of 6.6 g/kg;
5 groups of traditional Chinese medicines: administering Chinese medicinal decoction prepared from Chinese medicinal composition (10 parts of Scutellariae radix and 20 parts of herba Andrographitis) according to crude drug amount of 6.6 g/kg;
6 groups of traditional Chinese medicines: administering Chinese medicinal decoction prepared from Chinese medicinal composition (Scutellariae radix 10 parts, herba Andrographitis 20 parts, Prunellae Spica 3 parts, and flos Lonicerae 10 parts) according to crude drug amount of 6.6 g/kg;
7 groups of traditional Chinese medicines: administering Chinese medicinal decoction prepared from Chinese medicinal composition (Scutellariae radix 10 parts, herba Andrographitis 20 parts, Prunellae Spica 3 parts, and fructus forsythiae 10 parts) according to crude drug amount of 6.6 g/kg;
8 groups of traditional Chinese medicines: administering Chinese medicinal decoction prepared from Chinese medicinal composition (Scutellariae radix 10 parts, herba Andrographitis 20 parts, Prunellae Spica 3 parts, and herba Houttuyniae 10 parts) according to crude drug amount of 6.6 g/kg;
the blank control group was given an equivalent amount of physiological saline for intragastric administration.
3. Results
TABLE 2 Effect of the groups on body temperature Difference after administration
Note: p <0.05, P <0.01, compared to control group
The results show that: compared with a blank control group, the temperature difference of the traditional Chinese medicine 1 group, the traditional Chinese medicine 2 group and the traditional Chinese medicine 3 group is reduced to some extent, and has significant difference (P is less than 0.05, and P is less than 0.01), which shows that the traditional Chinese medicine composition has obvious inhibition effect on rabbit fever caused by bacterial endotoxin. Compared with the traditional Chinese medicine 2 group and the traditional Chinese medicine 3 group, the traditional Chinese medicine 1 group has the best effect under the condition of the same dosage.
EXAMPLE 20 clinical trials for the treatment of bacillary dysentery
1. Information(s)
The total 90 patients are accepted in the hospital from 9 months to 4 months in 2017 in 2015, the patients are randomly divided into 30 cases of traditional Chinese medicine and observation groups, and the comparative differences of the two groups of sex, age, disease course, clinical symptoms and the like have no statistical significance (P is more than 0.05) and are comparable.
The diagnosis standard refers to the "standard of curative effect for diagnosing symptom of traditional Chinese medicine". (1) History of epidemiology and unclean diet; (2) the clinical manifestations mainly include chill, fever, abdominal pain, diarrhea, mucus discharge, pus blood sample and stool; (3) the stool examination has a large amount of purulent cells, red blood cells, white blood cells and positive bacteria culture; (4) the hemogram examined the total number of leukocytes and neutrophilia.
Inclusion criteria were: meets the dysentery diagnosis standard and syndrome classification heat-toxin accumulation type in the Chinese medicine disease diagnosis curative effect standard.
2. Method of treatment
The traditional Chinese medicine comprises: the tablets of the antipyretic and antidote prepared in example 8 of the present invention were orally administered 3 to 5 tablets at a time 3 times a day for 7 consecutive days.
Observation group: (1) the cefoxitin injection is given in an anti-infection way, 80-160mg/kg per day and is dissolved in normal saline or 5% -10% glucose solution for intravenous drip for 3-4 times; (2) controlling hyperpyrexia and convulsion, performing physical cooling, and adding 1000ml of 1% warm saline for flowing enema; (3) oral rehydration salt corrects dehydration. The treatment is continued for 7 days.
3. Standard of therapeutic effect
Is formulated according to the standard of curative effect of diagnosis of traditional Chinese medicine diseases.
And (3) curing: the symptom disappears, the stool is normally checked by a microscope, and the pathogenic bacteria are continuously cultured for 3 times of negative turning.
Improvement: the symptom disappears or is relieved, the stool is normally checked by microscope, and the pathogenic bacteria cultivate yin to transform into yin or not transform into yin.
And (4) invalidation: no improvement in the symptom of stool by microscopic examination.
4. Therapeutic results
TABLE 3 comparison of therapeutic effects of the Chinese medicinal materials and the observation group
| Group of | n | Cure (%) | Effective (%) | Null (%) | Total effective (%) |
| Chinese medicine | 30 | 26(86.7) | 3(10.0) | 1(3.3) | 29(96.7) |
| Observation group | 30 | 16(53.3) | 10(33.3) | 4(13.3) | 26(86.7) |
The total effective rate of the traditional Chinese medicine is 96.7%, the western medicine group is 86.7%, the comparison difference of the two groups has statistical significance P less than 0.05%, and the traditional Chinese medicine composition has obvious curative effect on bacillary dysentery.
The above description is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, several modifications and additions can be made without departing from the method of the present invention, and these modifications and additions should also be regarded as the protection scope of the present invention.
Claims (8)
1. The traditional Chinese medicine composition for clearing away heat and toxic materials is characterized by being prepared from the following raw material medicines in parts by weight: 5-15 parts of scutellaria baicalensis, 15-25 parts of common andrographis herb and 1-6 parts of selfheal.
2. The traditional Chinese medicine composition according to claim 1, wherein the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 8-12 parts of scutellaria baicalensis, 18-22 parts of common andrographis herb and 2-4 parts of selfheal.
3. The traditional Chinese medicine composition according to claim 1, wherein the traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 10 parts of scutellaria baicalensis, 20 parts of common andrographis herb and 3 parts of common selfheal fruit-spike.
4. Use of a Chinese medicinal composition according to any one of claims 1 to 3 in the manufacture of a medicament for the treatment of bacillary dysentery.
5. The use according to claim 4, wherein the medicament is in the form of tablets, capsules, oral liquids, granules, pills, powders, pastes, pellets, suspensions, solutions, suppositories or patches.
6. The use of claim 5, wherein the medicament further comprises pharmaceutically acceptable excipients.
7. The process for preparing the medicament of claim 4, wherein the process comprises the steps of:
(1) mixing the raw materials in proportion, and pulverizing half of the raw materials into fine powder;
(2) decocting the rest materials in water twice, filtering, concentrating the filtrate, adding adjuvants and fine powder, and mixing to obtain mixture;
(3) drying, pulverizing, granulating, tabletting, and sugar coating.
8. The method of claim 7, wherein the excipient is brown sugar.
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| CN1698709A (en) * | 2005-04-12 | 2005-11-23 | 叶耀良 | Compound preparation of baikal skullcap root |
| CN101647867A (en) * | 2009-09-09 | 2010-02-17 | 肇庆星湖制药有限公司 | Traditional Chinese medicine composition for clearing away heat and toxic material |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1698709A (en) * | 2005-04-12 | 2005-11-23 | 叶耀良 | Compound preparation of baikal skullcap root |
| CN101647867A (en) * | 2009-09-09 | 2010-02-17 | 肇庆星湖制药有限公司 | Traditional Chinese medicine composition for clearing away heat and toxic material |
Non-Patent Citations (1)
| Title |
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| 黄芩穿心莲免煎剂治疗急性上呼吸道感染疗效观察;赵文;《陕西中医》;20100430;391 * |
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