CN103768519A - Compound medicine capable of improving anti-tumor curative effect of phosphamide and preparation method thereof - Google Patents
Compound medicine capable of improving anti-tumor curative effect of phosphamide and preparation method thereof Download PDFInfo
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- CN103768519A CN103768519A CN201310725266.8A CN201310725266A CN103768519A CN 103768519 A CN103768519 A CN 103768519A CN 201310725266 A CN201310725266 A CN 201310725266A CN 103768519 A CN103768519 A CN 103768519A
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Abstract
The invention discloses a compound medicine capable of improving the anti-tumor curative effect of phosphamide. The medicine is prepared from the following components in parts by weight: 10-30 parts of codonopsis pilosula, 15-30 parts of astragalus membranaceus, 15-30 parts of bighead atractylodes rhizome, 6-15 parts of curcuma zedoary, 10-30 parts of salviae miltiorrhizae, 5-10 parts of fructus schizandrae, 15-30 parts of humifuse euphorbia herb and 15-30 parts of sculellaria barbata. Years of clinical verification proves that the anti-tumor effect of the compound medicine is strengthened when combined with phosphamide, and the indexes of RBC (red blood cell) and HGB (hemoglobin) of peripheral blood can be improved; in combination with the traditional Chinese medicinal compound, an effect of 'reducing toxicity and improving effect' is achieved. The compound medicine is combined by macroscopic syndrome differentiation and microscopic disease differentiation, has the effects of tonfiying deficiency, strengthening body resistance, clearing heat, removing toxicity, attacking pathogen and eliminating stagnation, and has an excellent effect on the aspect of improving the anti-tumor curative effect of phosphamide.
Description
Technical field
The present invention relates to technical field of Chinese medicines, be specifically related to a kind of compound medicine that improves cyclophosphamide antitumor curative effect and preparation method thereof.
Background technology
Malignant tumor is one of Chronic Non-Communicable Diseases common in world wide, China national statistical data in 2009 shows that its sickness rate is 285.91/10 ten thousand people, its mortality rate is 180.54/10 ten thousand, is in the 1st of various diseases mortality rate, is greatly threatening the mankind's life and health.As one of three large means of oncotherapy, chemotherapy is at present for preoperative and postoperative and palliative treatment of kinds of tumors, but the existence of chemotherapy side effect, has affected the quality of antineoplaston.Therefore, improve the raising that chemotherapy side effect will be conducive to improve chemotherapy quality, increase the life cycle of tumour patient.
Cyclophosphamide is difunctional alkylating agent and cell cycle nonspecific agent (CCNSA), and itself and DNA occur crosslinked, suppress DNA synthetic, have the function that lowers or stop Growth of Cells.Be used for clinically malignant lymphoma, multiple myeloma, leukemia, breast carcinoma, ovarian cancer, cervical cancer, carcinoma of prostate, colon cancer, pulmonary carcinoma etc.But many tumor patients are being taken after cyclophosphamide, produce serious side effect, comprise nauseating, vomiting, bone marrow depression, have a stomachache, drop, alopecia, drowsiness etc.
Tumor tumor body increases rapidly at short notice, the qi-blood-body fluid of consume human body, make body and function day by day void decline, show as evil Sheng of just declining, if now method for the treatment of is take tonify deficiency righting as main, promote patient's self healthy energy, can alleviate the side effect such as bone marrow depression, improve symptom, be presented as " attenuation "; In conjunction with heat-clearing and toxic substances removing, removing blood stasis, strengthens antitumous effect, is presented as " potentiation " simultaneously.
Therapy of combining Chinese and Western medicine tumor is a developing direction of current oncotherapy, uses the unique advantage of Chinese medicine, can make up the deficiency of Western medicine, and Chinese medicine is with a long history in addition, and determined curative effect is simultaneously cheap, is suitable for promoting.
Summary of the invention
Goal of the invention: for the deficiencies in the prior art, the object of this invention is to provide a kind of compound medicine that improves cyclophosphamide antitumor curative effect, it possessed cheap, prepare and take all convenient, the feature such as curative effect is better simultaneously.Another object of the present invention is to provide a kind of preparation method of compound medicine of above-mentioned raising cyclophosphamide antitumor curative effect.
Technical scheme: in order to realize foregoing invention object, the technical solution used in the present invention is as follows:
Improve a compound medicine for cyclophosphamide antitumor curative effect, formed by each component of following parts by weight: 10～30 parts of Radix Codonopsis, 15～30 parts of the Radixs Astragali, 15～30 parts of the Rhizoma Atractylodis Macrocephalaes, 6～15 parts of Rhizoma Curcumae, 10～30 parts of Radix Salviae Miltiorrhizaes, 5～10 parts of Fructus Schisandrae Chinensis, 15～30 parts of Herba Euphorbiae Humifusaes, 15～30 parts of Herba Scutellariae Barbataes.
The dosage form of described compound medicine comprises decoction, syrup, mixture, granule, Tablet and Capsula agent.
Prepare the method for the compound medicine of described treatment tumor: by 8 taste Chinese medicines of formula ratio, decoct with water and extract 2～3 times, each 1～3 hour, collecting decoction concentrated and get final product; The weight of the water wherein, adding is 5～20 times of each taste medicine gross weight.
Prepare the method for the compound medicine of described treatment tumor: to a water that adds 5～20 times of weight of each taste medicine gross weight in 8 taste Chinese medicines, decoct and extract 2～3 times, each 1～3 hour; Collecting decoction, is concentrated into 60 ℃ of relative densities 1.05～1.15, adds ethanol to reaching 60～90%(volume ratio containing alcohol amount), leave standstill more than 12 hours, leaching supernatant, reclaims ethanol to obtaining to the greatest extent concentrated solution; In concentrated solution, add or do not add sucrose, sterilizing makes syrup or decoction; Or, in concentrated solution, add dextrin, steviosin, make tablet, capsule or granule.
Traditional Chinese medical theory think tumor aspect the cause of disease with the factor analysis such as body void, feelings will, exopathogen, diet, there is " healthy energy internal memory; heresy can not be done ", the feature of " institute of heresy gathers; its gas must be empty ", its basic pathogenesis is that damp and hot evil poison pents up, qi depression to blood stasis forms tumor, there are presentations such as weakened body resistance, expectorant is solidifying, blood stasis clinical, aspect treatment, often adopt the methods such as the body resistance strengthening and constitution consolidating, blood circulation promoting and blood stasis dispelling, resolving phlegm and softening hard masses, heat-clearing and toxic substances removing, treating the poisonous disease with poisonous drugs.The compound Chinese medicinal preparation of enhancing cyclophosphamide antitumous effect provided by the present invention, its prescription is made up of Radix Codonopsis, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae, Rhizoma Curcumae, Radix Salviae Miltiorrhizae, Fructus Schisandrae Chinensis, Herba Euphorbiae Humifusae, Herba Scutellariae Barbatae eight taste Chinese medicines, in side, Radix Codonopsis, the Radix Astragali, the Rhizoma Atractylodis Macrocephalae have righting QI invigorating, effect of invigorating the spleen for eliminating dampness, the property of medicine is gentle, the energy circulation of qi promoting of holding concurrently; Rhizoma Curcumae acrid in the mouth, hardship, temperature, has removing blood stasis, effect of promoting the circulation of QI to relieve pain.Radix Salviae Miltiorrhizae, Fructus Schisandrae Chinensis have effect that heart tonifying protects the liver; Herba Euphorbiae Humifusae, Herba Scutellariae Barbatae can be brought into play clearing away heat and cooling blood, the effect of subduing swelling and detoxicating; Therefore all medicines share, get its righting QI invigorating, effect of heat-clearing and toxic substances removing, suppresses tumor, alleviates side reaction.
Beneficial effect: compared with prior art, the compound medicine for the treatment of tumor of the present invention, through clinical verification for many years, combine with microcosmic differential diagnosis of diseases so that macroscopic view is dialectical, heat-clearing and toxic substances removing, attacks evil expel stagnation, the tonify deficiency of righting simultaneously, can improve cyclophosphamide antitumor curative effect, the hypertrophy of inhibition tumor cell, effectively alleviate clinical symptoms.The making of this medicine is simultaneously cheap, is easy to apply.
The specific embodiment
Below in conjunction with specific embodiment, the present invention is described further.
Embodiment 1
Improve a compound medicine for cyclophosphamide antitumor curative effect, formed by each component of following parts by weight:
15 parts of Radix Codonopsis, 30 parts of the Radixs Astragali, 15 parts of the Rhizoma Atractylodis Macrocephalaes, 10 parts of Rhizoma Curcumae, 15 parts of Radix Salviae Miltiorrhizaes, 5 parts of Fructus Schisandrae Chinensis, 15 parts of Herba Euphorbiae Humifusaes, 30 parts of Herba Scutellariae Barbataes, totally 8 taste medicines.
In prescription ratio, take the above 8 taste prepared slices of Chinese crude drugs, add the water of 10 times of amounts of crude drug gross weight, decoct and extract 3 times, each 1 hour.Collecting decoction, is concentrated into relative density 1.10(60 ℃ survey), add ethanol to reaching 60% containing alcohol amount, leave standstill more than 12 hours.Leaching supernatant, reclaims ethanol to most, and is concentrated into the about 1.10(60 of relative density ℃ survey).Add simple syrup, and the extremely suitable decoction pieces 1g of every mL of adding distil water, filtration, subpackage, sterilizing, obtain compound medicine syrup.
Embodiment 2
Improve a compound medicine for cyclophosphamide antitumor curative effect, formed by each component of following parts by weight: 30 parts of Radix Codonopsis, 15 parts of the Radixs Astragali, 30 parts of the Rhizoma Atractylodis Macrocephalaes, 6 parts of Rhizoma Curcumae, 10 parts of Radix Salviae Miltiorrhizaes, 5 parts of Fructus Schisandrae Chinensis, 15 parts of Herba Euphorbiae Humifusaes, 15 parts of Herba Scutellariae Barbataes, totally 8 taste medicines.
In prescription ratio, take the above 8 taste prepared slices of Chinese crude drugs, add the water of 20 times of amounts of crude drug gross weight, decoct and extract 3 times, each 1 hour.Collecting decoction, is concentrated into relative density 1.08(60 ℃ survey), add ethanol to reaching 60% containing alcohol amount, leave standstill more than 24 hours, leaching supernatant, reclaims ethanol extremely to the greatest extent, and is concentrated into the about 1.08(60 of relative density ℃ survey).Adding distil water, to the suitable decoction pieces 1g of every mL, mixes, filters, and subpackage, sterilizing, obtains compound medicine mixture.
Embodiment 3
Improve a compound medicine for cyclophosphamide antitumor curative effect, formed by each component of following parts by weight: 10 parts of Radix Codonopsis, 15 parts of the Radixs Astragali, 15 parts of the Rhizoma Atractylodis Macrocephalaes, 15 parts of Rhizoma Curcumae, 30 parts of Radix Salviae Miltiorrhizaes, 10 parts of Fructus Schisandrae Chinensis, 30 parts of Herba Euphorbiae Humifusaes, 30 parts of Herba Scutellariae Barbataes, totally 8 taste medicines.
In prescription ratio, take the above 8 taste prepared slices of Chinese crude drugs, add the water of 5 times of amounts of crude drug gross weight, decoct and extract 3 times, each 1 hour.Collecting decoction, is concentrated into relative density 1.10(60 ℃ survey), add ethanol to reaching 60% containing alcohol amount, leave standstill more than 24 hours, leaching supernatant, reclaims ethanol extremely to the greatest extent, and is concentrated into the about 1.33(60 of relative density ℃ survey).Add appropriate dextrin, stevioside, granulate, dry, granulate, subpackage, obtains compound medicine granule.
Embodiment 4
Improve a compound medicine for cyclophosphamide antitumor curative effect, formed by each component of following parts by weight: 30 parts of Radix Codonopsis, 30 parts of the Radixs Astragali, 30 parts of the Rhizoma Atractylodis Macrocephalaes, 10 parts of Rhizoma Curcumae, 10 parts of Radix Salviae Miltiorrhizaes, 5 parts of Fructus Schisandrae Chinensis, 15 parts of Herba Euphorbiae Humifusaes, 15 parts of Herba Scutellariae Barbataes, totally 8 taste medicines.
In prescription ratio, take the above 8 taste prepared slices of Chinese crude drugs, add the water of 10 times of amounts of crude drug gross weight, decoct and extract 3 times, each 1 hour.Collecting decoction, is concentrated into relative density 1.09(60 ℃ survey), add ethanol to reaching 60% containing alcohol amount, leave standstill more than 24 hours, leaching supernatant, reclaims ethanol extremely to the greatest extent, and is concentrated into the about 1.35(60 of relative density ℃ survey).Add appropriate amount of starch, granulate, dry, granulate, tabletting, coating, subpackage, obtains compound medicine tablet.
Embodiment 5
Improve a compound medicine for cyclophosphamide antitumor curative effect, formed by each component of following parts by weight: 15 parts of Radix Codonopsis, 30 parts of the Radixs Astragali, 30 parts of the Rhizoma Atractylodis Macrocephalaes, 10 parts of Rhizoma Curcumae, 10 parts of Radix Salviae Miltiorrhizaes, 5 parts of Fructus Schisandrae Chinensis, 15 parts of Herba Euphorbiae Humifusaes, 15 parts of Herba Scutellariae Barbataes, totally 8 taste medicines.
In prescription ratio, take the above 8 taste prepared slices of Chinese crude drugs, add the water of 10 times of amounts of crude drug gross weight, decoct and extract 3 times, each 1 hour.Collecting decoction, is concentrated into relative density 1.12(60 ℃ survey), add ethanol to reaching 60% containing alcohol amount, leave standstill more than 24 hours, leaching supernatant, reclaims ethanol extremely to the greatest extent, and is concentrated into the about 1.32(60 of relative density ℃ survey).Add appropriate amount of starch, granulate, dry, granulate, encapsulated, subpackage, obtains compound medicine capsule.
Embodiment 6
Chinese medicine compound is worked in coordination with the anti-ICR mice of cyclophosphamide H
22the experimentation of subcutaneous transplantation tumor, the prescription of compound medicine prepared by optional above-described embodiment 1-5, carries out the animal experiment of traditional Chinese compound medicine, difference is to make decoction and (by 8 taste Chinese medicines of formula ratio, add decocting in water and extract 2～3 times, each 1～3 hour, collecting decoction and get final product).Take typical embodiment 1 prescription as example, describe, other embodiment effects are suitable, specific as follows:
Laboratory animal: 40 of regular grade ICR mices, male and female half and half, body weight 18～22g, is provided the quality certification number by Zhejiang Academy of Medical Sciences Experimental Animal Center: SCXK(Zhejiang) 2008-0033.
Experimental agents: the decoction that Preparation Example 1 is write out a prescription, is concentrated into and is equivalent to crude drug concentration 2.25 g/mL.
Cyclophosphamide: specification 0.2g, purchased from Hengrui Medicine Co., Ltd., Jiangsu Prov., lot number: 20130122.It is made to the reserve liquid of 20 mg/mL with normal saline.
Laboratory animal modeling: under healthy ICR mice aseptic condition, get inoculation ascites tumor (the rat liver cancer H of 10～12 days
22cell), count with normal saline dilution by 1:4, be inoculated in the left axil of mice subcutaneous, 0.2 mL/ only, next day random packet.
Laboratory animal grouping and medication: 40 mices are divided into negative control group (normal saline group), positive controls (cyclophosphamide group), Chinese medicine compound group (with respect to 20 times of people's dosage) at random, and cyclophosphamide adds Chinese medicine compound group, 10 every group.Medication is in table 1, and negative control group gavages normal saline 0.4 mL/20 g body weight every day, and Chinese medicine compound group and cyclophosphamide add Chinese medicine compound group and gavage Chinese medicine compound 0.4 mL/20 g body weight, every day 1 time, continuous 10 days every day.Gavage the 3rd day, cyclophosphamide group and cyclophosphamide add Chinese medicine compound group, give intraperitoneal injection of cyclophosphamide 2 mg/10g body weight 1 time, and negative control group and compound recipe group are given lumbar injection equivalent normal saline.After last administration 2 hours, de-cervical vertebra puts to death animal, weigh, cut open tumor weighed, gets peripheral blood and detect index of correlation, and wherein tumor control rate calculates by following formula:
The average tumor of tumor control rate=(the average tumor weight of the average tumor weight-medicine of negative control group group)/negative control group heavy × 100%
Criterion: tumor control rate > 30%, experiment repeats 3 times altogether, learns by statistics and processes the person that has notable difference for there being antitumor action.
Table 1 ingredients and administering mode
Experimental result:
1) ordinary circumstance: after administration, observe the situations such as mice spirit, activity, diet, urine, feces every day, all no abnormal, eye, ear, nose, mouth are showed no secretions.
2) respectively organize tumour inhibiting rate result: administration is got mouse tumor tissue and found after 10 days, the tumor in each medication therapy groups is all dwindled, specifically relatively in table 2.
The each medication therapy groups of table 2 is to H
22the tumor inhibition effect of tumor-bearing mice
After administration, body weight is compared with positive controls, *: P < 0.01; *: P < 0.05, tumor is heavy compared with negative control group, Δ: P < 0.05; Δ Δ: P < 0.01.
Experimental result shows, the body weight of tumor-bearing mice is the most obvious with reducing after cyclophosphamide, increase to some extent compared with positive controls (cyclophosphamide group) and Chinese medicine compound group and cyclophosphamide add this Mice Body weight average of two groups of Chinese medicine compound group, and difference has statistical significance (P < 0.05 or P < 0.01).
The quality of Chinese medicine compound group tumor is lower than negative control group, and tumour inhibiting rate is 12.3%, but no difference of science of statistics.Use cyclophosphamide and Chinese medicine compound group inhibitory rate to 70.3% and combine, far away higher than a group of alone cyclophosphamide, illustrate that Combined with Chinese Herbal compound treatment strengthened the effect of tumor suppression, these two groups all have significant difference (P < 0.05 or P < 0.01) compared with negative control group, and the tumour inhibiting rate of three groups is respectively 35.0%, 12.3%, 70.3%.
3) Chinese medicine compound is intervened H to cyclophosphamide
22the impact of subcutaneous transplantation tumor mouse hemopoietic function:
The each medication therapy groups of table 3 is to H
22the impact of the hematological index of tumor-bearing mice
Drug combination group compared with alone cyclophosphamide group, *: P < 0.05, * *: P < 0.05, * * *: P < 0.05.
Experimental result shows, the peripheral blood leucocyte (WBC) of tumor-bearing mice is obvious with reducing after cyclophosphamide, but alone Chinese medicine compound group is little on its impact, and the WBC of Chinese medicine compound and cyclophosphamide coupling group increases to some extent than alone cyclophosphamide to some extent, but difference does not have statistical significance (P=0.51).
Compared with alone cyclophosphamide group, combine and use erythrocyte (RBC) and the hemoglobin (HGB) of Chinese medicine compound group obviously to raise, wherein RBC is from 7.69*10
12/ L rises to 8.93*10
12/ L, increases approximately 16%, and HGB rises to 129.14 g/L from 111.44 g/L, increases by 15.8%, and all has significant difference (P < 0.05).
Can find out from above experiment, this Chinese medicine compound and cyclophosphamide coupling, strengthened its antineoplastic effect, and RBC and the HGB index of human peripheral blood make moderate progress simultaneously, embody and in the time of conventional chemotherapy, combined use Chinese medicine compound, can produce the effect of " attenuation synergistic ".
Claims (4)
1. one kind is improved the compound medicine of cyclophosphamide antitumor curative effect, it is characterized in that, each component by following parts by weight forms: 10～30 parts of Radix Codonopsis, 15～30 parts of the Radixs Astragali, 15～30 parts of the Rhizoma Atractylodis Macrocephalaes, 6～15 parts of Rhizoma Curcumae, 10～30 parts of Radix Salviae Miltiorrhizaes, 5～10 parts of Fructus Schisandrae Chinensis, 15～30 parts of Herba Euphorbiae Humifusaes, 15～30 parts of Herba Scutellariae Barbataes.
2. the compound medicine of raising cyclophosphamide antitumor curative effect according to claim 1, is characterized in that: dosage form comprises decoction, syrup, mixture, granule, Tablet and Capsula agent.
3. a method of preparing the compound medicine of raising cyclophosphamide antitumor curative effect claimed in claim 1, is characterized in that: by 8 taste Chinese medicines of formula ratio, decoct with water and extract 2～3 times, each 1～3 hour, collecting decoction concentrated and get final product; The weight of the water wherein, adding is 5～20 times of each taste medicine gross weight.
4. a method of preparing the compound medicine of raising cyclophosphamide antitumor curative effect claimed in claim 1, is characterized in that: to the water that adds 5～20 times of weight of each taste medicine gross weight in 8 taste Chinese medicines, decoct and extract 2～3 times, each 1～3 hour; Collecting decoction, is concentrated into 60 ℃ of relative densities 1.05～1.15, adds ethanol to reaching 60～90% containing alcohol amount, leaves standstill more than 12 hours, and leaching supernatant, reclaims ethanol to obtaining to the greatest extent concentrated solution; In concentrated solution, add or do not add sucrose, sterilizing makes respectively syrup or decoction; Or, in concentrated solution, add dextrin, steviosin, make tablet, capsule or granule.
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| CN113648394A (en) * | 2021-09-14 | 2021-11-16 | 关晓仪 | Anticancer traditional Chinese medicine combination extract, single medicine extract composition and application |
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| CN1403147A (en) * | 2002-10-24 | 2003-03-19 | 河北以岭医药研究院有限公司 | Medicines composition for raising body's immunity and its prepn |
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| CN1403147A (en) * | 2002-10-24 | 2003-03-19 | 河北以岭医药研究院有限公司 | Medicines composition for raising body's immunity and its prepn |
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| 张代钊等: "中医药防治放化疗毒副反应的进展", 《湖南中医药导报》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN113648394A (en) * | 2021-09-14 | 2021-11-16 | 关晓仪 | Anticancer traditional Chinese medicine combination extract, single medicine extract composition and application |
| CN113648394B (en) * | 2021-09-14 | 2022-08-02 | 关晓仪 | Anticancer traditional Chinese medicine combination extract, single medicine extract composition and application |
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