CN103611057A - Breast cancer capsule for treating breast cancer and preparation method therefor - Google Patents

Abstract

The invention discloses a breast cancer capsule for treating breast cancer and a preparation method therefor. The ingredients of the breast cancer capsule are scorpion, raw radix astragali, roasted codonopsis pilosula, roasted rhizoma atractylodis macrocephalae, scirpus yagara ohw, curcuma zedoaria, winged euonymus twig, oldenlandia diffusa, solanum nigrum, bittersweet, rabdosia rubescens, radix actinidiae chinensis, raw coix seeds, umbellate pore fungus and white poria. The medicinal materials of the ingredients are mixed according to the ratios and crushed into podwer, the powder is sieved with a 120-mesh sieve and then capsulation is carried out. The breast cancer capsule can promote blood circulation, remove blood stasis, strengthen body resistance, eliminate pathogenic factors, and inhibit cancer cell division. The breast cancer capsule is green and non-poisonous, is easily accepted by patients, and all employs Chinese herbal medicines. The pain is little and the risk is low. The breast cancer capsule has no toxic or side effects.

Description

A kind of breast carcinoma capsule for the treatment of breast carcinoma and preparation method thereof

Technical field

The present invention relates to a kind of medicament for the treatment of breast carcinoma and preparation method thereof, be specifically related to a kind of breast carcinoma capsule and preparation method thereof, belong to drug world.

Background technology

Breast carcinoma is the common cancer that women ranks the first.The recent statistics data show of U.S.'s CA:A Cancer Journal for Clinicians magazine (factor of influence 94.262 in 2010) in 2011 announcement, the U.S. estimates to have 230480 routine women to suffer from breast carcinoma for 2011, account for 30% of women's de novo malignancy, first of rank women's Cancer Mortality.In China Beijing, Shanghai, Tianjin etc., metropolitan statistics shows that breast carcinoma is the modal malignant tumor of China women equally, and sickness rate is ascendant trend year by year.

The pathogenesis of breast carcinoma is very complicated, but crucial pathogenesis can be with " void, silt, poison " three words summaries, in treatment, take " righting, dredging, counteracting toxic substances " three large countermeasures, plan as a whole firmly, shoot the arrow at the target, emphasis medication, righting training unit, regulating the flow of vital energy become silted up, eleminating phlegm and freeing channels, dispersing pathogen accumulation, dialectical treating, finally make yin-Yang, QI and blood balance.

Summary of the invention

The object of the present invention is to provide the breast carcinoma capsule of a kind of patient suffering's of alleviating green non-poisonous treatment breast carcinoma.

For solving the problems of the technologies described above, the present invention adopts following technical scheme to realize:

Treat a breast carcinoma capsule for breast carcinoma, comprise the component of following weight portion: Scorpio 5-7, Radix Astragali 56-64, Radix Codonopsis (parched) 18-22, Rhizoma Atractylodis Macrocephalae (parched) 18-22, cyperus iria L. rhizoma scirpi 9-11, Rhizoma Curcumae 9-11, Ramulus Euonymi 9-11, Herba Hedyotidis Diffusae 9-11, Herba Solani Nigri 56-64, Herba Solani Lyrati 56-64, Rabdosia rubescens 56-64, Radix Actinidiae Chinensis 56-64, raw Semen Coicis 56-64, Polyporus 56-64 and Poria 56-64.

As preferably, described a kind of capsule for the treatment of breast carcinoma, comprises following parts by weight of component: Scorpio 6, Radix Astragali 60, Radix Codonopsis (parched) 20, Rhizoma Atractylodis Macrocephalae (parched) 20, cyperus iria L. rhizoma scirpi 10, Rhizoma Curcumae 10, Ramulus Euonymi 10, Herba Hedyotidis Diffusae 10, Herba Solani Nigri 60, Herba Solani Lyrati 60, Rabdosia rubescens 60, Radix Actinidiae Chinensis 60, raw Semen Coicis 60, Polyporus 60 and Poria 60.

Huang Shi in described composition, Radix Ginseng, the Rhizoma Atractylodis Macrocephalae have the effect that improves immunity of organisms, Radix Astragali energy air making-up and spleen enlivening, inducing diuresis to remove edema, modern medicine study show for tumor patient, and the consumption of the Radix Astragali only reaches the immunologic function that 60-90 gram of ability improves tumor patient; Radix Ginseng, Rhizoma Atractylodis Macrocephalae energy replenishing QI to invigorate the spleen, the untoward reaction that ameliorate tumor patient chemicotherapy causes preferably.

Rhizoma Sparganii in described composition, Rhizoma Curcumae, Ramulus Euonymi has the effect of blood circulation promoting and blood stasis dispelling, modern study is thought: " the blood stasis opinion " of tumor is closely related with the interior ubiquitous blood clotting hypercoagulability of patient body, thereby the existence of blood stasis disease can affect the curative effect of antineoplaston, while making patient occur recurring, the chance for the treatment of increases, therefore the utilization of activating blood circulation to dissipate blood stasis has very high clinical use value, concrete effect shows: 1. antitumor action 2. improve blood clotting hypercoagulability 3. to immune regulating action 4. anti-infectious function 5. adjust connective tissue metabolism, alleviate the connective fiber that radiotherapy causes.

Although the breast carcinoma cause of disease is complicated, but the traditional Chinese medical science thinks that void, silt, poison are basic reasons, ancient Chinese medicine doctor is all attached great importance to high violent agent treatment breast carcinoma, do " poison falls into evil dark, non-attacking and is unable to ", the basis of heat reliving and toxin-eliminating eliminating stagnation that Here it is, the Scorpio in described composition, winter Ganoderma, Herba Solani Nigri, Herba Solani Lyrati, Radix Actinidiae Chinensis, Herba Hedyotidis Diffusae can be used for heat-clearing and toxic substances removing eliminating stagnation.Wherein Scorpio has another name called Scorpio, is ancient arthropod, and the traditional Chinese medical science is called first of " five poisonous creatures: scorpion, viper, centipede, house lizard, toad ", is valuable animality medical material, has the effect that endogenous wind stopping stops expectorant, dredge the meridian passage, dispersing pathogen accumulation.

The capsule of described treatment breast carcinoma comprises six kinds of models, according to the weight of breast carcinoma and stadium compatibility.

The preparation method that another object of the present invention is to provide a kind of breast carcinoma capsule, comprises the following steps:

1) Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae are cleaned run through reed, section is dried, and wheat bran pavilion, in heat pot, is played to a cigarette to pot and rises into Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae and stir to deep yellow, it is standby that sieve goes wheat bran to cool;

2) Radix Astragali, Radix Actinidiae Chinensis, cyperus iria L. rhizoma scirpi, Rhizoma Curcumae, Polyporus, Poria are soaked in water respectively, soak into softening rear section, then drying for standby;

3) Herba Solani Lyrati, Herba Solani Nigri, Herba Hedyotidis Diffusae, Ramulus Euonymi, Rabdosia rubescens, to choose decontamination standby after dry;

4) giving birth to Semen Coicis cleans standby;

5) standby after Scorpio clean dry;

6) enter pulverizer after above-mentioned ten gomi herbs are mixed in proportion and be ground into end, cross 120 mesh sieves, encapsulated.

The every 2 grams of medicamental pulverata of described capsule fill one.

Beneficial effect of the present invention: the capsule for the treatment of breast carcinoma of the present invention has the following advantages:

1) in theory comprehensively, system, disclosed objectively the pathogenesis essence of patients with mastocarcinoma, Therapeutic Method and therapeutic goal have been broken through in the past single " counteracting toxic substances opinion " completely, and " weakened body resistance opinion ", " cold-phlegm opinion " and " insufficiency of kidney-YANG opinion " and " blood stasis opinion " etc. are one-sided view very.

2) for the patients with mastocarcinoma of different times, on the compatibility of various medicines and dosage, carry out difference medication, no matter according to the weight of breast carcinoma and stadium, be total to the Types of Medicine that compatibility goes out six kinds of models, be early, middle and late phase and age and physical strength, all can in one to No. six preparation, find suitable model.

3) green non-poisonous, patient accepts, all uses Chinese herbal medicine, and painful little, risk is low, has no side effect.

accompanying drawing explanation

Fig. 1 be in the present invention after different component Drug therapys macroscopic tumor figure.

Fig. 2 be in the present invention after Drug therapy the cartogram of tumour inhibiting rate.

specific embodiment

Below in conjunction with specific embodiment, the present invention is elaborated.

embodiment 1

King xx, female, 46 years old, live Rugao, Jiangsu Ru Cheng Wen Dingyuan, in 2006 because of the left radical operation of mastocarcinoma of left newborn wettability duct carcinoma ， Shanghai tumour hospital's row, postoperative doing 6 courses for the treatment of of regular chemotherapy, there is metastasis (metastases) in 2 years rear left axillary fossas and left thoracic wall, biopsy is reported as adenocarcinoma metastatic, starts to take breast carcinoma V number, amount to 12 courses for the treatment of, rear metastasis (metastases) all disappears, and through repeatedly the inspection of B ultrasonic PETCT blood tumor marker is all normal, life is normal at present.

embodiment 2

China xx, female, 56 years old, in August, 2002, postoperative chemotherapy 3 in early September, 2005 course for the treatment of B ultrasonic prompting hydrothorax, right axillary lymphs were tied many pieces at the right radical operation of mastocarcinoma of Shanghai xx hospital row, and biopsy turns out to be adenocarcinoma metastatic, again 3 courses for the treatment of of chemotherapy, lymph node has no and dwindles.Take breast carcinoma VI number 3 courses for the treatment of, lymph node disappears, and hydrothorax disappears, and lives good so far.

embodiment 3

Bian x, female, 81 years old, because of right swelling of the breast piece 1 year, in August, 2009, institute is medical, do B ultrasonic and point out the outside upper quadrant of right breast visible 3 centimetres of * 4 centimetres big or small lumps, the lower needle puncture biopsy of B ultrasonic guiding is reported as right breast carcinoma, because of patient's advanced age and be associated with multiple underlying diseases, old family's genus requires expectant treatment, through taking breast carcinoma IV number 6 courses for the treatment of, current right swelling of the breast piece is contracted to 1 centimetre, and without any special discomfort.

embodiment 4:the test of breast carcinoma capsule to human breast carcinoma nude mice by subcutaneous growth of xenografted

1 materials and methods

1.1 cell strain

Human breast cancer cell strain MDA-MB-231.

1.2 animal

Nude mice BALB/c-nu/nu, SPF level, female, 13～16g, experiment and raising are all carried out in ultra-clean laminar-flow rack under SPF level condition, and the water of sterilization treatment and SPF level special feed freely absorb for animal.

The foundation of 1.3 animal models

With containing the RPMI-1640 culture medium of 10% standard hyclone at 37 ℃, In vitro culture human breast cancer cell strain MDA-MB-231 under 5%CO2 condition, cell attachment growth.Collect the cell (continuing to cultivate 24h after going down to posterity) of exponential phase and be prepared into concentration and be about 1 * 10 ⁷the single cell suspension of individual/ml.By every nude mice 0.2ml injection, be inoculated in 40 right side of mice axillary fossas subcutaneous, after injection, with pincet folder pin hole, get final product for a moment (preventing that cell suspension from oozing out from pin hole).36 of postoperative one-tenth tumor nude mices, tumor formation rate 90%.

1.4 animal groupings, administration

With minor axis, the major diameter of vernier caliper measurement nude mice tumor, by Steel formula, calculate tumor volume=(major diameter * minor axis ²)/2(cm ³), to treat about one week, tumor growth is on average to 100mm ³after, it is divided into 6 groups at random, every group 6, be that matched group gives normal saline (0.2ml) gastric infusion every day, 1 group of (50mg/kg) gastric infusion every day of breast carcinoma prescription dosage, 2 groups of (100mg/kg) gastric infusions every day of breast carcinoma prescription dosage, 3 groups of (200mg/kg) gastric infusions every day of breast carcinoma prescription dosage, 4 groups of (500mg/kg) gastric infusions every day of breast carcinoma prescription dosage, positive control cyclophosphamide group (30mg/kg) gastric infusion every day.

The cardinal principle index of 1.5 tumor growths

After treatment, before each administration, use vernier caliper measurement tumor size, weigh nude mice body weight, administration is dislocation of cervical vertebra execution nude mice after 3 weeks, subcutaneous transplantation tumor together with the complete tumor tissues that separates of after birth, electronic balance takes tumor weight, calculates the average tumor of tumor control rate (%)=(the average tumor weight of the average tumor weight-medication of negative control group group)/negative control group heavy * 100%.

2, experimental result

2.1 nude mice tumor blocks amass (V=major diameter * minor axis ²cm ³/ 2)

Before treatment, respectively organize tumor growth situation basically identical, gross tumor volume indifference (P > 0.05).After treatment, Fig. 1 is shown in tumor perusal, and the long-pending statistics of tumor block is in Table 1.Result shows: with the comparison of normal saline group, and 1 group of (50mg/kg) no difference of science of statistics of prescription (P=0.286 > 0.05); Prescription 2 groups (100mg/kg) has significant difference (P=0.013 < 0.05); Prescription 3 groups (200mg/kg) has remarkable significant difference (P=0.008 < 0.01); Prescription 4 groups (500mg/kg) has remarkable significant difference (P=0.00099 < 0.001); CTX group (30mg/kg) has remarkable significant difference (P=0.00008 < 0.001).

Table 1: respectively organize nude mice tumor average volume after pharmaceutical intervention

Note: * P < 0.05 vs normal saline group, * * P < 0.01 vs normal saline group, * * * P < 0.001 vs normal saline group.

2.2 nude mice tumor piece quality and tumour inhibiting rates

Treatment posterior tuberosity piece quality is as table 2, and result shows: with the comparison of normal saline group, prescription 1 group (50mg/kg) has significant difference (P=0.023 < 0.05); Prescription 2 groups (100mg/kg) has significant difference (P=0.003 < 0.01); Prescription 3 groups (200mg/kg) has remarkable significant difference (P=0.0002 < 0.001); Prescription 4 groups (500mg/kg) has remarkable significant difference (P=0.00001 < 0.001); CTX group (30mg/kg) has remarkable significant difference (P < 0.001).

According to formula " the average tumor of tumor control rate (%)=(the average tumor weight of the average tumor weight-medication of negative control group group)/negative control group heavy * 100% ", calculate tumour inhibiting rate, the results are shown in Table 2, cartogram is shown in Fig. 2.Results suggest: high dose medicament is stronger to tumor inhibition effect than low-dose drugs, maximum dose level group (500mg/kg) reaches 47.8% to the suppression ratio of breast carcinoma subcutaneous transplantation tumor.

Table 2: respectively organize transplanted tumor average quality after pharmaceutical intervention

and tumour inhibiting rate

Note: * P < 0.05 vs normal saline group, * * P < 0.01 vs normal saline group, * * * P < 0.001 vs normal saline group.

Breast carcinoma capsule of the present invention can suppress the growth of people MDA-MB-231 Breast Carcinoma in nude mice subcutaneous transplantation tumor, and suppression ratio and normal saline group are more variant, and especially there were significant differences for high dose group, but lower than positive control cyclophosphamide group.

Above-described embodiment is only in order to illustrate technical scheme of the present invention; but not design of the present invention and protection domain are limited; those of ordinary skill of the present invention is modified or is equal to replacement technical scheme of the present invention; and not departing from aim and the scope of technical scheme, it all should be encompassed in claim scope of the present invention.

Claims (5)

1. a breast carcinoma capsule for the treatment of breast carcinoma, is characterized in that: the component that comprises following weight portion: Scorpio 5-7, Radix Astragali 56-64, Radix Codonopsis (parched) 18-22, Rhizoma Atractylodis Macrocephalae (parched) 18-22, cyperus iria L. rhizoma scirpi 9-11, Rhizoma Curcumae 9-11, Ramulus Euonymi 9-11, Herba Hedyotidis Diffusae 9-11, Herba Solani Nigri 56-64, Herba Solani Lyrati 56-64, Rabdosia rubescens 56-64, Radix Actinidiae Chinensis 56-64, raw Semen Coicis 56-64, Polyporus 56-64 and Poria 56-64.

2. a kind of breast carcinoma capsule for the treatment of breast carcinoma according to claim 1, is characterized in that: comprise following parts by weight of component: Scorpio 6, Radix Astragali 60, Radix Codonopsis (parched) 20, Rhizoma Atractylodis Macrocephalae (parched) 20, cyperus iria L. rhizoma scirpi 10, Rhizoma Curcumae 10, Ramulus Euonymi 10, Herba Hedyotidis Diffusae 10, Herba Solani Nigri 60, Herba Solani Lyrati 60, Rabdosia rubescens 60, Radix Actinidiae Chinensis 60, raw Semen Coicis 60, Polyporus 60 and Poria 60.

3. a kind of breast carcinoma capsule for the treatment of breast carcinoma according to claim 1, is characterized in that: the capsule of described treatment breast carcinoma comprises six kinds of models, according to the weight of breast carcinoma and stadium compatibility.

4. the preparation method of a kind of breast carcinoma capsule according to claim 3, is characterized in that: encapsulated one of every 2 grams of medicamental pulverata.

5. a preparation method for breast carcinoma capsule, is characterized in that: comprise the following steps:

1) Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae are cleaned run through reed, section is dried, and wheat bran pavilion, in heat pot, is played to a cigarette to pot and rises into Radix Codonopsis, the Rhizoma Atractylodis Macrocephalae and stir to deep yellow, it is standby that sieve goes wheat bran to cool;

2) Radix Astragali, Radix Actinidiae Chinensis, cyperus iria L. rhizoma scirpi, Rhizoma Curcumae, Polyporus, Poria are soaked in water respectively, soak into softening rear section, then drying for standby;

3) Herba Solani Lyrati, Herba Solani Nigri, Herba Hedyotidis Diffusae, Ramulus Euonymi, Rabdosia rubescens, to choose decontamination standby after dry;

4) giving birth to Semen Coicis cleans standby;

5) standby after Scorpio clean dry

6) enter pulverizer after above-mentioned ten gomi herbs are mixed in proportion and be ground into end, cross 120 mesh sieves, encapsulated.

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