CN101380372A - Pharmaceutical composition for treating cervical vertebra disease and its preparation method - Google Patents
Pharmaceutical composition for treating cervical vertebra disease and its preparation method Download PDFInfo
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- CN101380372A CN101380372A CNA200810213257XA CN200810213257A CN101380372A CN 101380372 A CN101380372 A CN 101380372A CN A200810213257X A CNA200810213257X A CN A200810213257XA CN 200810213257 A CN200810213257 A CN 200810213257A CN 101380372 A CN101380372 A CN 101380372A
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Abstract
The invention relates to a medicine, in particular to a pharmaceutical composite which can be used for treating cervical spondylosis caused by various factors, and the pharmaceutical composite for treating cervical spondylosis is formed by the following materials according to weight percentage: 180g of astragalus root, 280g of Dangshen, 180g of angelica, 600g of salvia miltiorrhiza, 180g of red paeonia, 180g of peach kernel, 180g of safflower, 180g of ligusticum chuanxiong hort, 180g of earthworm, 240g of radix puerariae, 60g of asarum and 60g of liquorice. The medicine is mainly used for complementing qi and blood, and the medicine also has the efficacies of promoting blood circulation for removing obstruction in collaterals, cultivating spirit and relieving uneasiness and inducing resuscitation, thus achieving good effect of calming brain and relieving pain. The medicine can treat both the symptoms and root causes, has comprehensive efficacies and can be used for treating cerebrovascular insufficiency, vertigo, syncope, dizziness, cervical spine and muscles rigidity, limb numbness, and the like, caused by various cervical spondylosis and cervical hyperplasia.
Description
Technical field
The present invention relates to a kind of medicine, specifically relate to a kind of cerebral blood supply insufficiency that various cervical spondylosiss and hyperosteogeny cause that can be used for, dizzy, faint, the pharmaceutical composition of dizzy, cervical vertebra and the treatment cervical spondylosis that cervical muscle is stiff, numb limbs and tense tendons etc. is sick and preparation method thereof.
Background technology
Cervical spondylosis (vertebral artery type) is the common a kind of frequently-occurring disease of middle-aged and elderly people, also produces a kind of occupation disease, along with development of modernization, and the popularizing of computer, the increasing of private car, online the huge of crowd increases, and this disease is tending towards the crowd's of rejuvenation surge.The harm of this disease is also more and more, gives patient, family and society causes great burden to give the spasmolytic agent clinically, blood vessel expands Drug therapys such as strong agent, vasodilation stabilizing agent, but the following shortcoming of said medicine ubiquity: 1, must take for a long time; 2, some curative effect of medication is not good; 3, side effect is big.
Summary of the invention
The technical problem to be solved in the present invention is the deficiency that exists at prior art, provide a kind of select that high-quality Chinese crude drug rational formula forms for use can be used for cerebral blood supply insufficiency that various cervical spondylosiss and hyperosteogeny cause, dizzy, faint, a kind of pharmaceutical composition for the treatment of cervical spondylosis of dizzy, cervical vertebra and diseases such as cervical muscle is stiff, numb limbs and tense tendons and preparation method thereof.
A kind of pharmaceutical composition for the treatment of cervical spondylosis of the present invention and preparation method thereof is achieved by following technical proposals, and the pharmaceutical composition of described treatment cervical spondylosis is to be made by the following raw materials in percentage by weight medicine: the Radix Astragali 5%-10%; Radix Codonopsis 8%-15%; Radix Angelicae Sinensis 5%-10%; Radix Salviae Miltiorrhizae 20%-28%; Radix Paeoniae Rubra 5%-10%; Semen Persicae 5%-10%; Flos Carthami 5%-10%; Rhizoma Chuanxiong 5%-10%; Pheretima 5%-10%; Radix Puerariae 7%-12%; Herba Asari 2%-3%; Radix Glycyrrhizae 2%-3%.
The present invention is a kind of to treat the pharmaceutical composition of cervical spondylosis owing to all adopt the Chinese crude drug that has no side effect, so drug safety.Wherein the Radix Astragali is a monarch drug, and QI invigorating makes gas prosperous capable with short blood, blood stasis dispelling and just not hindering, and help the power of all medicines.The Radix Codonopsis invigorating the spleen and replenishing QI is promoted the production of body fluid and is nourished blood, and to help the usefulness of the Radix Astragali, is equipped with Radix Angelicae Sinensis, blood stasis dispelling is arranged and has not hindered the wonderful of blood, is subjects' medicine.Radix Salviae Miltiorrhizae, Radix Paeoniae Rubra, Semen Persicae, Flos Carthami, Rhizoma Chuanxiong help the Radix Angelicae Sinensis blood circulation promoting and blood stasis dispelling, and the Pheretima collateral dredging is active, are adjuvant drug.The Radix Puerariae nature and flavor are sweet, hot, cool, have relieving muscles diaphoresis, analgesic promoting the production of body fluid; Herba Asari, property suffering, temperature have the effect of temperature three-way meridian, dispersing cold for relieving pain, sensible refreshment, and Radix Glycyrrhizae is messenger drug with coordinating the actions of various ingredients in a prescription.Because of the cervical spondylosis patient is person in middle and old age's commonly encountered diseases, frequently-occurring disease.Middle-aged and elderly people healthy energy is lost empty, deficiency of both the liver and kidney, and because of void causes the stasis of blood, venation block, muscle pulse classic network lose supports, and therefore, the cervical vertebra sufferer is person in middle and old age's commonly encountered diseases, frequently-occurring disease.The present invention's prescription is held concurrently with promoting blood circulation to remove obstruction in the collateral based on strongly invigorating QI and blood, reposes and calms the nerves, and sensible refreshment reaches and decides brain, analgesic good result; This medicine specimen is made up and is controlled, and effect is comprehensive, can be used for cerebral blood supply insufficiency that various cervical spondylosiss and hyperosteogeny cause, dizzy, faint, dizzy, cervical vertebra and diseases such as cervical muscle is stiff, numb limbs and tense tendons.
Experimental example 1.
One, the medicament composition capsule of treatment cervical spondylosis is to the microcirculatory influence of animal
(1) experiment material
Laboratory animal: Kunming mouse, body weight 28-33g, the male and female dual-purpose, available from zoopery center, Qinghai Province, the certificate of competency: No. the 01st, the moving word of doctor.
The experiment medicine: the medicament composition capsule of treatment cervical spondylosis, lot number 960705, specification: the 0.3g/ grain, produce by Qinghai Gela Dandong Pharmaceutical Industry Co., Ltd..Time spent is mixed with the suspension of desired concn with distilled water.
(2) experimental technique and result
1, microcirculation of mouse auricle is influenced
Get 40 of Kunming kind white mice, body weight 28-33g male and female half and half are divided into four groups at random, lumbar injection urethane 1.8g/kg, after the anesthesia, fixedly auricle amplifies 140 times of observations under microcirculation microscope, is the object of observation with the collecting capillary, measure preceding caliber of administration and fluidised form, lumbar injection 50% is treated the medicament composition capsule of cervical spondylosis then, and dosage is 5g, 2g/kg.Positive control, anisodamine (654-2) 80mg/kg, negative control group is given the isodose normal saline.5min after the mensuration administration, above two indexs during 10min.Lumbar injection epinephrine (Sdr) 1mg/kg then continues to measure when giving 2min, 10min behind the epinephrine, 20min, 30min
Two, the medicament composition capsule of treatment cervical spondylosis is to the effect of hemorheological property
(1) experiment material
Laboratory animal: the SD rat, body weight 150-180g, male and female half and half are available from Qinghai Province's Experimental Animal Center.The animal quality certification: No. the 01st, the moving word of doctor.
The experiment medicine: the medicament composition capsule of treatment cervical spondylosis, lot number: 960705 specifications: the 0.3g/ grain, to produce by Qinghai Gela Dandong Pharmaceutical Industry Co., Ltd., the time spent is mixed with the suspension of desired concn through distilled water; FUFANG DANSHEN PIAN, new east station of Guangzhou health pharmaceutical factory, lot number 951101,0.42g/ sheet.
(2) experimental technique and result
Get 40 of SD rats, male and female half and half, be divided into 4 groups at random, divide normal group, model group, model+compound Salviae Miltiorrhizae group, the medicament composition capsule group of model+treatment cervical spondylosis, (height, the dosage of low dose group is respectively 5g, 2.5g) crude drug/Kg, and every day, ig was administered once, successive administration 9 days, after the last administration 30 minutes, the tail vein was injected (having pushed away in 10 minutes) 10% high molecular dextran 6.5ml/kg, rat femoral blood-letting after 30 minutes fast, decide whole blood contrast viscosity with 3-999B microcirculation hemorheology system synthesis instrument side, plasma viscosity and RBC aggregate index etc. are measured the RBC hematocrit with micro-packed cell volume instrument, the results are shown in Table.
Three, the medicament composition capsule of treatment cervical spondylosis is to the influence of anesthetized dog vertebral artery blood flow
(1) experiment material
Laboratory animal: hybrid dog, available from market.
Experiment medicine: the same.
(2) experimental technique and result
Get the above healthy dogs of 10kg, intravenous injection dragon barbital sodium 30ml/kg anesthesia, lying on the back is fixed on the operating-table, intubate behind the separation femoral artery links to each other in sphygomanometer, separates vertebral artery, put the pincerlike probe of electromagnetic flowmeter that internal diameter conforms to its thickness, be connected in MF-27 type square wave electromagnetic flowmeter.Isolate duodenum through the xiphoid-process lower cut.Operative stabilization is after duodenum is treated the medicament composition capsule and the contrast liquid of cervical spondylosis: 0.01% tween physiology salt the results are shown in Table:
Four, the medicament composition capsule of treatment cervical spondylosis is to the influence of anti-stress ability
(1) experiment material
Laboratory animal: Kunming mouse, body weight 18-22g, male and female half and half, available from Qinghai Province's Experimental Animal Center, the laboratory animal quality certification: blue or green doctor is moving to be learned No. 01.
The experiment medicine: the medicament composition capsule of (1) treatment cervical spondylosis, lot number: 960705, specification: the 0.3g/ grain, to produce by Qinghai Gela Dandong Pharmaceutical Industry Co., Ltd., the time spent is made into the suspension of desired concn with distilled water.
(2) etidocine tablet, Jintan City, Jiangsu pharmaceutical factory lot number: 960006, specification: 25mg/ sheet.
(2) experimental technique and result
The water temperature of constant water bath box is adjusted to 55 ± 0.5 ℃, the bottom of a can is immersed about water-bath 2cm, the heating back is as thermostimulation.Mice is dropped into hot plate, with the stopwatch record incubation period of pain reaction (play back leg or lick the rear foot) appears as basic pain threshold, choose pain threshold 55 of the mices of 5-30 second, be divided into 5 groups by basic pain threshold, set matched group, the positive drug group, high, medium and low dosage group of administration component, dosage is respectively 5g, 2.5g, 1.25g/kg carries out the ig administration, and 1h uses with quadrat method and measures each Mus pain threshold (pain threshold surpasses 60 seconds and stops test) after the administration, calculates the threshold of pain and improves percentage rate.
Brief summary
The medicament composition capsule The pharmacological results of treatment cervical spondylosis proves, the medicament composition capsule of treatment cervical spondylosis has obvious dilating effect to Mice Auricle circulation caliber, and can to Mice Auricle microcirculation fluidised form branch matter remarkable enhancing be arranged to the effect of the antiadrenergic drug draw; Can significantly reduce high molecular dextran and whole blood viscosity and RBC ability of aggregation when making rat " blood stasis ", improve its hemorheological property; The vertebral artery blood vessel had tangible dilating effect; Inhibition improves its pain threshold to the pain reaction that the mice thermostimulation causes.
Experimental example 2.
The medicament composition capsule toxicity test data of treatment cervical spondylosis
1, acute toxicity test: oral said preparation is 16g/kg to the MTD of Kunming mouse, and this dosage is equivalent to 196 times of clinical plan oral dose, and the no phenomena of mortality and any toxic and side effects produce.
2, long term toxicity test: heavy dose of (10g/kg), gavage this agent the long course of treatment (90 days), and to body weight gain, liver, the renal function of Doistar rat, hematology and important histoorgan do not have the overt toxicity infringement, show that said preparation toxicity is low, oral safety.
The specific embodiment
Below in conjunction with embodiment a kind of drug technique scheme for the treatment of cervical spondylosis of the present invention is further described.
A kind of pharmaceutical composition for the treatment of cervical spondylosis of the present invention is made by the following raw materials in percentage by weight medicine:
Radix Astragali 180g Radix Codonopsis 280g Radix Angelicae Sinensis 180g
Radix Salviae Miltiorrhizae 600g Radix Paeoniae Rubra 180g Semen Persicae 180g
Flos Carthami 180g Rhizoma Chuanxiong 180g Pheretima 180g
Radix Puerariae 240g Herba Asari 60g Radix Glycyrrhizae 60g.
Described a kind of preparation of drug combination method for the treatment of cervical spondylosis is:
1) the full side of 12 flavor cervical vertebra Yiganning capsules 12 flavor medical materials are got the crude drug that meets the crude drug quality standard, through selected, remove impurity, wash, dry.
2) get Radix Angelicae Sinensis, Flos Carthami, Rhizoma Chuanxiong, Herba Asari vapor distillation, extract Aromatic water 1000ml, it is standby to separate volatile oil, and the solution after separation extracting container is in addition collected standby.
3) medicinal residues and all the other Radixs Astragali, Radix Codonopsis, Radix Salviae Miltiorrhizae etc. eight flavor Chinese medicines decoct with water secondary, and each 1.5 hours, merge decoction liquor, filter, filtrate and above-mentioned solution mix, and are concentrated into relative density and are 1.35-1.38 (50 ℃-60 ℃ time survey) extractum.
4) get extractum and add dextrin and fully stir in mixer in right amount, make the suitable soft material of soft or hard, 14 mesh sieves are granulated, 65 ℃ of-70 ℃ of oven dry, and granulate is selected with 14 mesh sieves in dry back, and title is decided after the weight standby.
5) 2 isolated volatile oil are sprayed in the dried granule airtight, fully stir the back and claim to decide weight promptly.
6) 1000 of the capsules of every heavy 0.3g dressed up above-mentioned granule by fill capsule.
Embodiment 1.
By 1000 preparation units:
Radix Astragali 125g, Radix Codonopsis 200g, Radix Angelicae Sinensis 125g, Radix Salviae Miltiorrhizae 500g, Radix Paeoniae Rubra 125g, Semen Persicae 125g, Flos Carthami 125g, Rhizoma Chuanxiong 125g, Pheretima 125g, Radix Puerariae 180g, Herba Asari 50g, Radix Glycyrrhizae 50g.
Described a kind of preparation of drug combination method for the treatment of cervical spondylosis is:
1) the full side of 12 flavor cervical vertebra Yiganning capsules 12 flavor medical materials are got the crude drug that meets the crude drug quality standard, through selected, remove impurity, wash, dry.
2) get Radix Angelicae Sinensis, Flos Carthami, Rhizoma Chuanxiong, Herba Asari vapor distillation, extract Aromatic water 1000ml, it is standby to separate volatile oil, and the solution after separation extracting container is in addition collected standby.
3) medicinal residues and all the other Radixs Astragali, Radix Codonopsis, Radix Salviae Miltiorrhizae etc. eight flavor Chinese medicines decoct with water secondary, and each 1.5 hours, merge decoction liquor, filter, filtrate and above-mentioned solution mix, and are concentrated into relative density and are 1.35-1.38 (50 ℃-60 ℃ time survey) extractum.
4) get extractum and add dextrin and fully stir in mixer in right amount, make the suitable soft material of soft or hard, 14 mesh sieves are granulated, 65 ℃ of-70 ℃ of oven dry, and granulate is selected with 14 mesh sieves in dry back, and title is decided after the weight standby.
5) 2 isolated volatile oil are sprayed in the dried granule airtight, fully stir the back and claim to decide weight promptly.
6) 1000 of the capsules of every heavy 0.3g dressed up above-mentioned granule by fill capsule.
Embodiment 2.
By 1000 preparation units:
Radix Astragali 180g, Radix Codonopsis 280g, Radix Angelicae Sinensis 180g, Radix Salviae Miltiorrhizae 600g, Radix Paeoniae Rubra 180g, peach 180g, Flos Carthami 180g, Rhizoma Chuanxiong 180g, Pheretima 180g, Radix Puerariae 240g, Herba Asari 60g, Radix Glycyrrhizae 60g.
Described a kind of preparation of drug combination method for the treatment of cervical spondylosis is:
1) the full side of 12 flavor cervical vertebra Yiganning capsules 12 flavor medical materials are got the crude drug that meets the crude drug quality standard, through selected, remove impurity, wash, dry.
2) get Radix Angelicae Sinensis, Flos Carthami, Rhizoma Chuanxiong, Herba Asari vapor distillation, extract Aromatic water 1000ml, it is standby to separate volatile oil, and the solution after separation extracting container is in addition collected standby.
3) medicinal residues and all the other Radixs Astragali, Radix Codonopsis, Radix Salviae Miltiorrhizae etc. eight flavor Chinese medicines decoct with water secondary, and each 1.5 hours, merge decoction liquor, filter, filtrate and above-mentioned solution mix, and are concentrated into relative density and are 1.35-1.38 (50 ℃-60 ℃ time survey) extractum.
4) get extractum and add dextrin and fully stir in mixer in right amount, make the suitable soft material of soft or hard, 14 mesh sieves are granulated, 65 ℃ of-70 ℃ of oven dry, and granulate is selected with 14 mesh sieves in dry back, and title is decided after the weight standby.
5) 2 isolated volatile oil are sprayed in the dried granule airtight, fully stir the back and claim to decide weight promptly.
6) 1000 of the capsules of every heavy 0.3g dressed up above-mentioned granule by fill capsule.
Embodiment 3.
By 1000 preparation units:
Radix Astragali 250g, Radix Codonopsis 375g, Radix Angelicae Sinensis 250g, Radix Salviae Miltiorrhizae 700g, Radix Paeoniae Rubra 250g, Semen Persicae 250g, Flos Carthami 250g, Rhizoma Chuanxiong 250g, Pheretima 250g, Radix Puerariae 350g, Herba Asari 75g, Radix Glycyrrhizae 75g.
Described a kind of preparation of drug combination method for the treatment of cervical spondylosis is:
1) the full side of 12 flavor cervical vertebra Yiganning capsules 12 flavor medical materials are got the crude drug that meets the crude drug quality standard, through selected, remove impurity, wash, dry.
2) get Radix Angelicae Sinensis, Flos Carthami, Rhizoma Chuanxiong, Herba Asari vapor distillation, extract Aromatic water 1000ml, it is standby to separate volatile oil, and the solution after separation extracting container is in addition collected standby.
3) medicinal residues and all the other Radixs Astragali, Radix Codonopsis, Radix Salviae Miltiorrhizae etc. eight flavor Chinese medicines decoct with water secondary, and each 1.5 hours, merge decoction liquor, filter, filtrate and above-mentioned solution mix, and are concentrated into relative density and are 1.35-1.38 (50 ℃-60 ℃ time survey) extractum.
4) get extractum and add dextrin and fully stir in mixer in right amount, make the suitable soft material of soft or hard, 14 mesh sieves are granulated, 65 ℃ of-70 ℃ of oven dry, and granulate is selected with 14 mesh sieves in dry back, and title is decided after the weight standby.
5) 2 isolated volatile oil are sprayed in the dried granule airtight, fully stir the back and claim to decide weight promptly.
6) 1000 of the capsules of every heavy 0.3g dressed up above-mentioned granule by fill capsule.
Claims (2)
1, a kind of pharmaceutical composition for the treatment of cervical spondylosis is characterized in that described pharmaceutical composition is to be made by the following raw materials in percentage by weight medicine:
Radix Astragali 180g Radix Codonopsis 280g Radix Angelicae Sinensis 180g
Radix Salviae Miltiorrhizae 600g Radix Paeoniae Rubra 180g Semen Persicae 180g
Flos Carthami 180g Rhizoma Chuanxiong 180g Pheretima 180g
Radix Puerariae 240g Herba Asari 60g Radix Glycyrrhizae 60g.
2, a kind of preparation of drug combination method for the treatment of cervical spondylosis as claimed in claim 1, it is characterized in that: described preparation method is
1) the full side of 12 flavor cervical vertebra Yiganning capsules 12 flavor medical materials are got the crude drug that meets the crude drug quality standard, through selected, remove impurity, wash, dry.
2) get Radix Angelicae Sinensis, Flos Carthami, Rhizoma Chuanxiong, Herba Asari vapor distillation, extract Aromatic water 1000ml, it is standby to separate volatile oil, and the solution after separation extracting container is in addition collected standby..
3) eight flavor Chinese medicines such as medicinal residues and all the other Radixs Astragali, Radix Codonopsis, Radix Salviae Miltiorrhizae decoct with water secondary, and each 1.5 hours, merge decoction liquor, filter, filtrate and above-mentioned solution mix, and are concentrated into the extractum that relative density is 1.35-1.38.
4) get extractum and add dextrin and fully stir in mixer in right amount, make the suitable soft material of soft or hard, 14 mesh sieves are granulated, 65 ℃ of-70 ℃ of oven dry, and granulate is selected with 14 mesh sieves in dry back, and title is decided after the weight standby.
5) 2 isolated volatile oil are sprayed in the dried granule airtight, fully stir the back and claim to decide weight promptly.
6) 1000 of the capsules of every heavy 0.3g dressed up above-mentioned granule by fill capsule.
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| Application Number | Priority Date | Filing Date | Title |
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| CNA200810213257XA CN101380372A (en) | 2008-04-24 | 2008-08-16 | Pharmaceutical composition for treating cervical vertebra disease and its preparation method |
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| CN200810044310.8 | 2008-04-24 | ||
| CNA200810213257XA CN101380372A (en) | 2008-04-24 | 2008-08-16 | Pharmaceutical composition for treating cervical vertebra disease and its preparation method |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103565969A (en) * | 2013-11-14 | 2014-02-12 | 侯亭美 | Traditional Chinese medicine composition for treating soft tissue injury and fracture |
| CN103599213A (en) * | 2013-11-14 | 2014-02-26 | 黄海 | Medicinal composition for treating bone fracture and preparation method thereof |
| CN103920021A (en) * | 2014-04-23 | 2014-07-16 | 宝应县中医医院 | Drug composition for treating vertebral artery type cervical spondylopathy, as well as preparation method thereof |
| CN104800306A (en) * | 2015-04-21 | 2015-07-29 | 南京恒邦生态农业科技发展有限公司 | Pill with functions of promoting blood circulation to remove meridian obstruction and relieving pain and preparation method thereof |
| CN105748782A (en) * | 2016-02-25 | 2016-07-13 | 太和县中医院 | Traditional Chinese medicine oral liquid for treating cervical spondylosis |
| CN109966459A (en) * | 2018-12-28 | 2019-07-05 | 南京海昌中药集团有限公司 | A kind of Chinese materia medica preparation and preparation method thereof with alleviation neck fatigue and improvement cervical vertebra hyperplasia function |
| CN116211945A (en) * | 2022-03-24 | 2023-06-06 | 南方医科大学中西医结合医院 | Traditional Chinese medicine composition, preparation method thereof and application thereof in preparation of medicine for treating or preventing chronic cerebral circulation inefficiency |
-
2008
- 2008-08-16 CN CNA200810213257XA patent/CN101380372A/en active Pending
Cited By (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103565969A (en) * | 2013-11-14 | 2014-02-12 | 侯亭美 | Traditional Chinese medicine composition for treating soft tissue injury and fracture |
| CN103599213A (en) * | 2013-11-14 | 2014-02-26 | 黄海 | Medicinal composition for treating bone fracture and preparation method thereof |
| CN103565969B (en) * | 2013-11-14 | 2015-02-25 | 刘涛 | Traditional Chinese medicine composition for treating soft tissue injury and fracture |
| CN103920021A (en) * | 2014-04-23 | 2014-07-16 | 宝应县中医医院 | Drug composition for treating vertebral artery type cervical spondylopathy, as well as preparation method thereof |
| CN104800306A (en) * | 2015-04-21 | 2015-07-29 | 南京恒邦生态农业科技发展有限公司 | Pill with functions of promoting blood circulation to remove meridian obstruction and relieving pain and preparation method thereof |
| CN105748782A (en) * | 2016-02-25 | 2016-07-13 | 太和县中医院 | Traditional Chinese medicine oral liquid for treating cervical spondylosis |
| CN109966459A (en) * | 2018-12-28 | 2019-07-05 | 南京海昌中药集团有限公司 | A kind of Chinese materia medica preparation and preparation method thereof with alleviation neck fatigue and improvement cervical vertebra hyperplasia function |
| CN116211945A (en) * | 2022-03-24 | 2023-06-06 | 南方医科大学中西医结合医院 | Traditional Chinese medicine composition, preparation method thereof and application thereof in preparation of medicine for treating or preventing chronic cerebral circulation inefficiency |
| CN116211945B (en) * | 2022-03-24 | 2024-02-09 | 南方医科大学中西医结合医院 | Traditional Chinese medicine composition, preparation method thereof and application thereof in preparation of medicine for treating or preventing chronic cerebral circulation inefficiency |
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Open date: 20090311 |