CN103920021A - Drug composition for treating vertebral artery type cervical spondylopathy, as well as preparation method thereof - Google Patents
Drug composition for treating vertebral artery type cervical spondylopathy, as well as preparation method thereof Download PDFInfo
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Abstract
The invention discloses a drug composition for treating vertebral artery type cervical spondylopathy. The drug composition comprises the following active ingredients in parts by weight: 5-6 parts of lumbricus, 5-6 parts of rhizoma gastrodiae, 5-6 parts of semen persicae, 5-6 parts of flos carthami, 5-6 parts of radix angelicae sinensis, 5-6 parts of pericarpium citri reticulatae, 5-6 parts of radix paeoniae rubra, 5-6 parts of rhizoma pinelliae preparatum, 10-15 parts of radix puerariae and 26-30 parts of radix astragali seu hedysari. The drug composition is precise in compatibility, can promote blood circulation to remove meridian osbstruction, calm the liver, reduce phlegm, and improve vertigo, and is especially applicable to vertebral artery type cervical spondylopathy. The drug composition can be used for Neurovascular headache, dizziness and the like, besides vertebral artery type cervical spondylopathy. All active ingredients of the drug composition are mixed and crushed, and filled into capsules to obtain the capsule product, without the complicated procedures such as purification, and the preparation method is simple and easy.
Description
Technical field
The present invention relates to a kind of pharmaceutical composition, particularly relate to a kind of pharmaceutical composition for the treatment of vertebral artery type of cervical spondylosis, the invention still further relates to the preparation method of this pharmaceutical composition.
Background technology
Cervical spondylosis claims again cervical spine syndrome, is the general name of osteoarthritis of cervical spine, proliferative cervical spondylosis, cervical syndrome, Cervical disc extrusion, is a kind ofly to change into basic illness with degeneration pathology.Mainly due to cervical vertebra strain for a long time, hyperosteogeny, or prolapse of intervertebral disc, ligament thicken, and causes cervical vertebra spinal cord, nerve root or vertebral artery pressurized, occurs a series of handicapped clinical syndromes.Show as intervertebral disc degradation itself and insecondary a series of pathological change thereof, as vertebra joint unstability, loosening; Vertebral pulp is given prominence to or is deviate from; Bony spur forms; The spinal canal stenosis of ligament plumpness and secondary etc., stimulate or have oppressed the tissues such as contiguous nerve root, spinal cord, vertebral artery and cervical region sympathetic nerve, cause series of symptoms and sign.
How treat in the market cervical spondylosis sets about from rheumatism stasis blocking aspect, its formula mostly also is promoting blood circulation to remove obstruction in the collateral, except humidifying numbness, cervical spondylosis has multiple disease type, also has in qi depression to blood stasis, deficiency of the liver and kindey, liver-yang, to disturb etc., as vertebral artery type of cervical spondylosis except rheumatism stasis blocking, need research worker further investigation, development such as can be applicable to disturb on qi depression to blood stasis, deficiency of the liver and kindey, liver-yang at the Chinese medicine formula of disease type, is suitable for SPONDYLOPATHY OF VERTEBRAL ARTERY TYPE, for Patients with Cervical Spondylopathy provides drug treatment more widely.
Summary of the invention
The technical problem to be solved in the present invention is to provide a kind of pharmaceutical composition for the treatment of vertebral artery type of cervical spondylosis, and this pharmaceutical composition can promoting blood circulation to remove obstruction in the collateral, and suppressing the hyperactive liver reduces phlegm, and effectively improves vertebral artery type of cervical spondylosis people's dizzy symptom, and relieving the pain caused by diseases shortens treatment cycle.
For solving the problems of the technologies described above, the invention provides a kind of pharmaceutical composition for the treatment of vertebral artery type of cervical spondylosis, it comprises following active constituent, Pheretima 5-6 weight portion, Rhizoma Gastrodiae 5-6 weight portion, Semen Persicae 5-6 weight portion, Flos Carthami 5-6 weight portion, Radix Angelicae Sinensis 5-6 weight portion, Pericarpium Citri Reticulatae 5-6 weight portion, Radix Paeoniae Rubra 5-6 weight portion, Rhizoma Pinelliae Preparatum 5-6 weight portion, Radix Puerariae 10-15 weight portion, Radix Astragali 26-30 weight portion.
The pharmaceutical composition of above-mentioned treatment vertebral artery type of cervical spondylosis, wherein, the active constituent of described pharmaceutical composition comprises Pheretima 5 weight portions, Rhizoma Gastrodiae 6 weight portions, Semen Persicae 5 weight portions, Flos Carthami 5 weight portions, Radix Angelicae Sinensis 5 weight portions, Pericarpium Citri Reticulatae 6 weight portions, Radix Paeoniae Rubra 6 weight portions, Rhizoma Pinelliae Preparatum 5 weight portions, Radix Puerariae 11 weight portions, the Radix Astragali 27 weight portions.
The pharmaceutical composition of above-mentioned treatment vertebral artery type of cervical spondylosis, wherein, described pharmaceutical composition also comprises Ramulus Uncariae Cum Uncis, and the active constituent of this pharmaceutical composition comprises Pheretima 5-6 weight portion, Rhizoma Gastrodiae 5-6 weight portion, Semen Persicae 5-6 weight portion, Flos Carthami 5-6 weight portion, Radix Angelicae Sinensis 5-6 weight portion, Pericarpium Citri Reticulatae 5-6 weight portion, Radix Paeoniae Rubra 5-6 weight portion, Rhizoma Pinelliae Preparatum 5-6 weight portion, Radix Puerariae 10-15 weight portion, Ramulus Uncariae Cum Uncis 16-20 weight portion, Radix Astragali 26-30 weight portion.
The pharmaceutical composition of above-mentioned treatment vertebral artery type of cervical spondylosis, wherein, the active constituent of described pharmaceutical composition comprises Pheretima 5 weight portions, Rhizoma Gastrodiae 6 weight portions, Semen Persicae 5 weight portions, Flos Carthami 5 weight portions, Radix Angelicae Sinensis 5 weight portions, Pericarpium Citri Reticulatae 6 weight portions, Radix Paeoniae Rubra 6 weight portions, Rhizoma Pinelliae Preparatum 5 weight portions, Radix Puerariae 11 weight portions, Ramulus Uncariae Cum Uncis 16 weight portions, the Radix Astragali 27 weight portions.
The pharmaceutical composition of above-mentioned treatment vertebral artery type of cervical spondylosis, wherein, described pharmaceutical composition also comprises Flos Chrysanthemi, and the active constituent of this pharmaceutical composition comprises Pheretima 5-6 weight portion, Rhizoma Gastrodiae 5-6 weight portion, Semen Persicae 5-6 weight portion, Flos Carthami 5-6 weight portion, Flos Chrysanthemi 5-6 weight portion, Radix Angelicae Sinensis 5-6 weight portion, Pericarpium Citri Reticulatae 5-6 weight portion, Radix Paeoniae Rubra 5-6 weight portion, Rhizoma Pinelliae Preparatum 5-6 weight portion, Radix Puerariae 10-15 weight portion, Ramulus Uncariae Cum Uncis 16-20 weight portion, Radix Astragali 26-30 weight portion.
The pharmaceutical composition of above-mentioned treatment vertebral artery type of cervical spondylosis, wherein, the active constituent of described pharmaceutical composition comprises Pheretima 5 weight portions, Rhizoma Gastrodiae 6 weight portions, Semen Persicae 5 weight portions, Flos Carthami 5 weight portions, Flos Chrysanthemi 5 weight portions, Radix Angelicae Sinensis 5 weight portions, Pericarpium Citri Reticulatae 6 weight portions, Radix Paeoniae Rubra 6 weight portions, Rhizoma Pinelliae Preparatum 5 weight portions, Radix Puerariae 11 weight portions, Ramulus Uncariae Cum Uncis 16 weight portions, the Radix Astragali 27 weight portions.
The pharmaceutical composition of above-mentioned treatment vertebral artery type of cervical spondylosis, wherein, described pharmaceutical composition is adopting on the basis of each active constituent, add pharmaceutically acceptable adjuvant, be prepared into oral formulations according to conventional method, can be pill, granule, capsule, tablet, drop pill or oral solutions, be preferably capsule.
The present invention also provides a kind of preparation method of pharmaceutical composition for the treatment of vertebral artery type of cervical spondylosis, and it comprises the steps:
A, by the each active constituent in described pharmaceutical composition in 60-70 DEG C dry 4-7 hour;
B, by the each active component co-grinding after drying in step a, cross 80-100 mesh sieve, stir, incapsulate, make capsule.
Pharmaceutical composition of the present invention except can for the preparation for the treatment of vertebral artery type of cervical spondylosis medicine, can also for the preparation for the treatment of angioneurotic headache medicine.
In pharmaceutical composition of the present invention, each active constituent has following pharmacologically active and effect:
Pheretima: heat clearing away arresting convulsion, dredging collateral, relieving asthma, diuresis, for cerebral thrombosis, cerebral infarction, coronary heart disease, apoplexy, joint paralysis, numb limbs and tense tendons, hemiplegia, the diseases such as vascular hypertension.
Rhizoma Gastrodiae: embellish but not dry, main enter Liver Channel, be longer than suppressing the hyperactive liver to relieve the wind syndrome, the diseases such as, numb limbs and tense tendons dizzy for having a headache, infantile convulsion, epilepsy, tic, tetanus.
Semen Persicae: have effect of blood circulation promoting and blood stasis dispelling, loosening bowel to relieve constipation, can be used for amenorrhea, dysmenorrhea, WEIJIA mass in the abdomen, injury from falling down, dryness of the intestine constipation etc.
Flos Carthami: promoting blood circulation to restore menstrual flow, eliminating stasis to stop pain, swells and ache for amenorrhea, dysmenorrhea, lochia, obstruction of qi in the chest and cardialgia, the stagnant stomachache of the stasis of blood, the twinge of the breast side of body, traumatic injury, skin infection.
Flos Chrysanthemi: there is effect of dispelling wind, heat clearing away, improving eyesight, removing toxic substances, the diseases such as primary treatment headache, dizzy, conjunctival congestion, irritable feverish sensation of chest and heart, furuncle, toxic swelling
Radix Angelicae Sinensis: warm in nature, sweet in the mouth, pungent, returns liver, the heart, spleen channel, enriches blood and invigorates blood circulation, menstruction regulating and pain relieving, loosening bowel to relieve constipation.For blood deficiency and yellow complexion, dizzy cardiopalmus, menoxenia, amenorrhea dysmenorrhea, asthenia cold abdominalgia, dryness of the intestine constipation, rheumatic arthralgia, injury from falling down, ulcer sores.
Pericarpium Citri Reticulatae: warm in nature, acrid in the mouth, bitter in the mouth, enter spleen channel, stomach warp, lung meridian, regulating qi-flowing for strengthening spleen, in tune, dampness, reduces phlegm.Cure mainly the distension and fullness in the abdomen of stagnation of QI in spleen and stomach or pain, dyspepsia, abdominal distention uncomfortable in chest, indigestion and loss of appetite loose stool in turbid damp resistance, phlegm-damp is stopped up the cough and asthma of lung.
Radix Paeoniae Rubra: cold nature, bitter in the mouth, returns Liver Channel, clearing away heat and cooling blood, eliminating stasis to stop pain.For maculae caused by violent heat pathogen, spit blood, epistaxis, conjunctival congestion and swelling pain, hypochondriac pain due to stagnation of liverQI, amenorrhea dysmenorrhea, lump in the abdomen stomachache, injury from falling down, carbuncle skin infection.
Rhizoma Pinelliae Preparatum: warm in nature, acrid in the mouth, return spleen, stomach, lung meridian, cure mainly drying dampness to eliminate phlegm, for abundant expectoration cough with asthma, phlegm retention vertigo and palpitation, dizziness due to wind-phlegm, syncope due to accumulation of phlegm headache.
Radix Puerariae: cool in nature, sweet in the mouth is pungent, having induces sweat brings down a fever, promotes the production of body fluid, the several functions such as rash, yang invigorating antidiarrheal, can control fever caused by exogenous pathogens headache, hypertension neck pain, thirsty, quench one's thirst, measles without adequate eruption, heat rash, the various diseases such as have loose bowels.
Ramulus Uncariae Cum Uncis: cold nature, sweet in the mouth, micro-hardship, return liver, pericardium channel; Hard the diving of matter fallen, and has heat clearing away suppressing the hyperactive liver, and effect of relieving spasm by subduing liver-wind cures mainly liver-fire superinverse headache conjunctival congestion, and excessive rising of liver-YANG is had a dizzy spell, intenseness of heat wind symptom infantile convulsion, and infantile convulsion, night cry, eclamposia, paralysis due to windstroke, podomere contraction is anxious.
The Radix Astragali: slightly warm in nature, sweet in the mouth, return lung, spleen, liver, kidney channel, enhancing human body immunity function, protect the liver, diuresis, defying age, anti-stress, blood pressure lowering and antibacterial action more widely.
Chinese medicine thinks that cervical spondylosis belongs to " dizzy " category, and pharmaceutical composition of the present invention focuses on benefiting QI for activating blood circulation, and suppressing the hyperactive liver reduces phlegm.The traditional Chinese medical science is thought " qi being the governor of blood ", " blood being the material foundation of QI ".Specifically, be to exist qi promoting blood production, promoting the circulation of blood, take the photograph four square relations of plane such as blood and blood being the material foundation of QI.The deficiency of vital energy promotes unable, and blood is slow; The stagnation of QI blood is unsmooth not smooth, very can form blood stasis.Secondly " all wind trembling and dizziness, all belong to liver." liver-wind stirring up internally, above disturbing key clearly can be to dizziness and headache.Semen Persicae, Flos Carthami, Radix Paeoniae Rubra, Pheretima, Pericarpium Citri Reticulatae promoting flow of QI and blood in pharmaceutical composition of the present invention, disperse blood stasis and dredge collateral; Rhizoma Gastrodiae, Rhizoma Pinelliae Preparatum suppressing the hyperactive liver to relieve the wind syndrome, eleminating phlegm and freeing channels, can increase cerebral blood flow, reduces vascular resistance; Radix Puerariae born fluid, relaxing muscles and tendons network, energy diastole internal carotid artery, controls a backache, improves microcirculation, cerebral circulation and peripheral circulation.The Radix Astragali, Radix Angelicae Sinensis benefiting vital QI and blood, QI and blood foot, promotes effectively, the stasis of blood is reduced phlegm and is disappeared, disease disappearing recovered, all medicines share, QI and blood must be filled, liver-wind is obtained interests of, the expectorant stasis of blood must except and all diseases disappear.On the basis of the basic side of the present invention, can also add Ramulus Uncariae Cum Uncis, itself and Rhizoma Gastrodiae, Rhizoma Pinelliae Preparatum synergism, strengthened liver-wind, the dredging collateral effect of calming down.The invention allows for a kind of optimization formula, on the basis that adds Ramulus Uncariae Cum Uncis, add Flos Chrysanthemi, Flos Chrysanthemi, Ramulus Uncariae Cum Uncis, Rhizoma Gastrodiae and Rhizoma Pinelliae Preparatum synergism, strengthen drug effect, effectively improves cerebral blood supply amount, improves dizzy symptom, can significantly shorten treatment cycle.
Pharmaceutical composition compatibility of the present invention is rigorous, can promoting blood circulation to remove obstruction in the collateral, and suppressing the hyperactive liver reduces phlegm, improve dizzy symptom, be specially adapted to vertebral artery type of cervical spondylosis, pharmaceutical composition of the present invention, except for vertebral artery type of cervical spondylosis, can also be used for the diseases such as angioneurotic headache, dizziness.Pharmaceutical composition of the present invention, by each active constituent co-grinding, is filled into capsule and can obtains capsule, and without the complicated procedures of forming such as purifying, preparation method is simple.
Detailed description of the invention
Describe the present invention in detail below in conjunction with embodiment.
Embodiment 1
Get Pheretima 5 weight portions, Rhizoma Gastrodiae 6 weight portions, Semen Persicae 5 weight portions, Flos Carthami 5 weight portions, Radix Angelicae Sinensis 5 weight portions, Pericarpium Citri Reticulatae 6 weight portions, Radix Paeoniae Rubra 6 weight portions, Rhizoma Pinelliae Preparatum 5 weight portions, Radix Puerariae 11 weight portions, the Radix Astragali 27 weight portions, dry 5 hours in 70 DEG C, co-grinding, cross 100 mesh sieves, stir, incapsulate, every dress 0.2g, makes capsule.
Embodiment 2
Get Pheretima 5 weight portions, Rhizoma Gastrodiae 6 weight portions, Semen Persicae 5 weight portions, Flos Carthami 5 weight portions, Radix Angelicae Sinensis 5 weight portions, Pericarpium Citri Reticulatae 6 weight portions, Radix Paeoniae Rubra 6 weight portions, Rhizoma Pinelliae Preparatum 5 weight portions, Radix Puerariae 11 weight portions, Ramulus Uncariae Cum Uncis 16 weight portions, the Radix Astragali 27 weight portions, dry 5 hours in 70 DEG C, co-grinding, cross 100 mesh sieves, stir, incapsulate, every dress 0.2g, makes capsule.
Embodiment 3
Get Pheretima 5 weight portions, Rhizoma Gastrodiae 6 weight portions, Semen Persicae 5 weight portions, Flos Carthami 5 weight portions, Flos Chrysanthemi 5 weight portions, Radix Angelicae Sinensis 5 weight portions, Pericarpium Citri Reticulatae 6 weight portions, Radix Paeoniae Rubra 6 weight portions, Rhizoma Pinelliae Preparatum 5 weight portions, Radix Puerariae 11 weight portions, Ramulus Uncariae Cum Uncis 16 weight portions, the Radix Astragali 27 weight portions, dry 5 hours in 70 DEG C, co-grinding, cross 100 mesh sieves, stir, incapsulate, every dress 0.2g, makes capsule.
Embodiment 4
Get Pheretima 6 weight portions, Rhizoma Gastrodiae 5 weight portions, Semen Persicae 6 weight portions, Flos Carthami 6 weight portions, Flos Chrysanthemi 6 weight portions, Radix Angelicae Sinensis 6 weight portions, Pericarpium Citri Reticulatae 5 weight portions, Radix Paeoniae Rubra 5 weight portions, Rhizoma Pinelliae Preparatum 6 weight portions, Radix Puerariae 10 weight portions, Ramulus Uncariae Cum Uncis 18 weight portions, the Radix Astragali 26 weight portions, dry 7 hours in 60 DEG C, co-grinding, cross 80 mesh sieves, stir, incapsulate, every dress 0.2g, makes capsule.
Embodiment 5
Get Pheretima 6 weight portions, Rhizoma Gastrodiae 6 weight portions, Semen Persicae 6 weight portions, Flos Carthami 6 weight portions, Flos Chrysanthemi 6 weight portions, Radix Angelicae Sinensis 6 weight portions, Pericarpium Citri Reticulatae 6 weight portions, Radix Paeoniae Rubra 6 weight portions, Rhizoma Pinelliae Preparatum 6 weight portions, Radix Puerariae 15 weight portions, Ramulus Uncariae Cum Uncis 20 weight portions, the Radix Astragali 30 weight portions, dry 4 hours in 70 DEG C, co-grinding, cross 100 mesh sieves, stir, incapsulate, every dress 0.2g, makes capsule.
Clinical trial
Test example 1
Select my institute's vertebral artery type of cervical spondylosis case 240 examples, in age 35-70 year, be divided at random experimental group 1, experimental group 2, experimental group 3 and matched group, every group of each 60 examples.
Experimental group 1, experimental group 2 and experimental group 3 are taken respectively the capsule in embodiment 1, embodiment 2, embodiment 3, and every day 3 times, each 5, matched group is taken the JINGFUKANG KELI of Jingfukang Pharmaceutical Group Co., Ltd..The equal medication of experimental group 1, experimental group 2, experimental group 3 and matched group 30 days.
Efficacy evaluation:
Recovery from illness: cervical vertigo is eliminated, the symptoms such as no headache, dim eyesight;
Take a turn for the better: cervical vertigo symptom alleviates, and still has tinnitus, dim eyesight etc.;
Invalid: symptom is without improvement.
Clinical experiment the results are shown in Table 1.
Table 1
Can find out through above-mentioned clinical statistics, pharmaceutical composition of the present invention is in medication after 30 days, and total effective rate can reach more than 85%, and experimental group 3 has reached more than 93% especially, for improving, dizzy symptom effect is remarkable, and the total effective rate of matched group is only 76.7%.Experimental group 2 has added Ramulus Uncariae Cum Uncis on the basis of experimental group 1, the Ramulus Uncariae Cum Uncis adding, play synergism with the active component in experimental group 1, can promote dredging collateral, improve cerebral blood supply amount, effectively alleviate dizzy symptom, accelerate treatment speed, the recovery from illness improvement rate of experimental group 2 in the time of medication 20 days (in table 1 the accounting rate of " recovery from illness " and the accounting rate of " improvement " add and) is 83.3% (55%+28.3%), is also that total effective rate 85% is substantially suitable with the experimental group 1 medication recovery from illness improvement rate of 30 days.Experimental group 3 has further added Flos Chrysanthemi on the basis of experimental group 2, optimize formula of the present invention, form the formula of optimum of the present invention, experimental group 3 is 80% at the medication recovery from illness improvement rate of 10 days, be better than the experimental group 1 medication recovery from illness improvement rate 73.3% of 20 days, the experimental group 3 medications cure rate of 20 days is 68.3%, higher than the experimental group 2 medications cure rate of 30 days 66.7%, the experimental group 3 medication recovery from illness improvement rate of 20 days is 91.7%, is also that total effective rate is identical with the experimental group 2 medication recovery from illness improvement rate of 30 days.Visible, in the formula of experimental group 1, add Ramulus Uncariae Cum Uncis, the same Rhizoma Gastrodiae of Ramulus Uncariae Cum Uncis, Rhizoma Pinelliae Preparatum combined effect, shortened treatment time of Patients with Cervical Spondylopathy, on this side's basis, further coordinate and add Flos Chrysanthemi, Rhizoma Gastrodiae, Rhizoma Pinelliae Preparatum, Ramulus Uncariae Cum Uncis and Flos Chrysanthemi synergism, can accelerate endogenous wind stopping dredging collateral, improve cerebral blood supply amount, suppressing the hyperactive liver reduces phlegm, and has effectively improved dizzy symptom, has significantly shortened the treatment cycle of Patients with Cervical Spondylopathy.
Test example 2
Choose the court's angioneurotic headache, dizzy 80 cases, in age 30-65 year, Therapeutic Method, takes the capsule in embodiment 3, every day 3 times, each 5, medication 10 days.
Efficacy evaluation:
Recovery from illness: headache, dizzy transference cure;
Take a turn for the better: headache transference cure, dizzy symptom alleviates;
Invalid: symptom is without improvement.
Therapeutic outcome: recovery from illness 49 examples, 22 examples that take a turn for the better, no effect 9, total effective rate 88.75%, therapeutic process has no untoward reaction.
Visible pharmaceutical composition of the present invention can be used in treatment angioneurotic headache, giddy disease, and does not find untoward reaction.
Claims (10)
1. treat the pharmaceutical composition of vertebral artery type of cervical spondylosis for one kind, it comprises following active constituent, Pheretima 5-6 weight portion, Rhizoma Gastrodiae 5-6 weight portion, Semen Persicae 5-6 weight portion, Flos Carthami 5-6 weight portion, Radix Angelicae Sinensis 5-6 weight portion, Pericarpium Citri Reticulatae 5-6 weight portion, Radix Paeoniae Rubra 5-6 weight portion, Rhizoma Pinelliae Preparatum 5-6 weight portion, Radix Puerariae 10-15 weight portion, Radix Astragali 26-30 weight portion.
2. the pharmaceutical composition for the treatment of vertebral artery type of cervical spondylosis as claimed in claim 1, wherein, the active constituent of described pharmaceutical composition comprises Pheretima 5 weight portions, Rhizoma Gastrodiae 6 weight portions, Semen Persicae 5 weight portions, Flos Carthami 5 weight portions, Radix Angelicae Sinensis 5 weight portions, Pericarpium Citri Reticulatae 6 weight portions, Radix Paeoniae Rubra 6 weight portions, Rhizoma Pinelliae Preparatum 5 weight portions, Radix Puerariae 11 weight portions, the Radix Astragali 27 weight portions.
3. the pharmaceutical composition for the treatment of vertebral artery type of cervical spondylosis as claimed in claim 1, wherein, described pharmaceutical composition also comprises Ramulus Uncariae Cum Uncis, and the active constituent of this pharmaceutical composition comprises Pheretima 5-6 weight portion, Rhizoma Gastrodiae 5-6 weight portion, Semen Persicae 5-6 weight portion, Flos Carthami 5-6 weight portion, Radix Angelicae Sinensis 5-6 weight portion, Pericarpium Citri Reticulatae 5-6 weight portion, Radix Paeoniae Rubra 5-6 weight portion, Rhizoma Pinelliae Preparatum 5-6 weight portion, Radix Puerariae 10-15 weight portion, Ramulus Uncariae Cum Uncis 16-20 weight portion, Radix Astragali 26-30 weight portion.
4. the pharmaceutical composition for the treatment of vertebral artery type of cervical spondylosis as claimed in claim 3, wherein, the active constituent of described pharmaceutical composition comprises Pheretima 5 weight portions, Rhizoma Gastrodiae 6 weight portions, Semen Persicae 5 weight portions, Flos Carthami 5 weight portions, Radix Angelicae Sinensis 5 weight portions, Pericarpium Citri Reticulatae 6 weight portions, Radix Paeoniae Rubra 6 weight portions, Rhizoma Pinelliae Preparatum 5 weight portions, Radix Puerariae 11 weight portions, Ramulus Uncariae Cum Uncis 16 weight portions, the Radix Astragali 27 weight portions.
5. the pharmaceutical composition for the treatment of vertebral artery type of cervical spondylosis as claimed in claim 3, wherein, described pharmaceutical composition also comprises Flos Chrysanthemi, and the active constituent of this pharmaceutical composition comprises Pheretima 5-6 weight portion, Rhizoma Gastrodiae 5-6 weight portion, Semen Persicae 5-6 weight portion, Flos Carthami 5-6 weight portion, Flos Chrysanthemi 5-6 weight portion, Radix Angelicae Sinensis 5-6 weight portion, Pericarpium Citri Reticulatae 5-6 weight portion, Radix Paeoniae Rubra 5-6 weight portion, Rhizoma Pinelliae Preparatum 5-6 weight portion, Radix Puerariae 10-15 weight portion, Ramulus Uncariae Cum Uncis 16-20 weight portion, Radix Astragali 26-30 weight portion.
6. the pharmaceutical composition for the treatment of vertebral artery type of cervical spondylosis as claimed in claim 5, wherein, the active constituent of described pharmaceutical composition comprises Pheretima 5 weight portions, Rhizoma Gastrodiae 6 weight portions, Semen Persicae 5 weight portions, Flos Carthami 5 weight portions, Flos Chrysanthemi 5 weight portions, Radix Angelicae Sinensis 5 weight portions, Pericarpium Citri Reticulatae 6 weight portions, Radix Paeoniae Rubra 6 weight portions, Rhizoma Pinelliae Preparatum 5 weight portions, Radix Puerariae 11 weight portions, Ramulus Uncariae Cum Uncis 16 weight portions, the Radix Astragali 27 weight portions.
7. as the pharmaceutical composition of the treatment vertebral artery type of cervical spondylosis of any one in claim 1-6 as described in asking, wherein, described pharmaceutical composition is pill, granule, capsule, tablet, drop pill or oral solutions.
8. the pharmaceutical composition for the treatment of vertebral artery type of cervical spondylosis as claimed in claim 7, wherein, described pharmaceutical composition is capsule.
9. a preparation method for the pharmaceutical composition for the treatment of vertebral artery type of cervical spondylosis claimed in claim 8, it comprises the steps:
A, by the each active constituent in described pharmaceutical composition in 60-70 DEG C dry 4-7 hour;
B, by the each active component co-grinding after drying in step a, cross 80-100 mesh sieve, stir, incapsulate, make capsule.
10. the application of the pharmaceutical composition described in claim 1-8 in preparation treatment vertebral artery type of cervical spondylosis, angioneurotic headache, dizzy medicine.
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| CN104491393A (en) * | 2015-01-04 | 2015-04-08 | 霍山县中医院 | Traditional Chinese medicine for treating vertebral artery type cervical spondylopathy |
| CN104740302A (en) * | 2015-03-17 | 2015-07-01 | 李培培 | Traditional Chinese medicine composition for treating Qi deficiency and blood stasis type lumbar spinal stenosis disease |
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| CN104491393A (en) * | 2015-01-04 | 2015-04-08 | 霍山县中医院 | Traditional Chinese medicine for treating vertebral artery type cervical spondylopathy |
| CN104740302A (en) * | 2015-03-17 | 2015-07-01 | 李培培 | Traditional Chinese medicine composition for treating Qi deficiency and blood stasis type lumbar spinal stenosis disease |
| CN104740302B (en) * | 2015-03-17 | 2019-03-01 | 李培培 | A kind of Chinese medicine composition for treating Qi deficiency blood stasis type lumbar spinal stenosis |
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