CN103948863A - Plaster for treating nerve-root type cervical spondylosis and preparation method of plaster - Google Patents
Plaster for treating nerve-root type cervical spondylosis and preparation method of plaster Download PDFInfo
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- CN103948863A CN103948863A CN201410173689.8A CN201410173689A CN103948863A CN 103948863 A CN103948863 A CN 103948863A CN 201410173689 A CN201410173689 A CN 201410173689A CN 103948863 A CN103948863 A CN 103948863A
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- rhizoma
- treatment
- cervical
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- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
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Abstract
The invention discloses a plaster for treating nerve-root type cervical spondylosis and a preparation method of the plaster. The plaster is prepared from the following raw materials by weight mass: 8-14 parts of radix puerariae, 6-9 parts of lycopodium clavatum, 9-15 parts of rhizoma dioscoreae nipponicae, 5-10 parts of notopterygium root, 4-11 parts of zedoary, 7-13 parts of zaocys dhumnade, 6-15 parts of pyrola, 6-9 parts of uncaria, 1-5 parts of toddalia asiatuaLam and 1-9 parts of manis pentadactyla. The plaster has the functions of invigorating the circulation of blood, stimulating the menstrual flow, relieving the pain and dredging the collaterals, and has good curative effect on the nerve-root type cervical spondylosis and the complications thereof.
Description
Technical field
The invention discloses a kind of plaster for the treatment of cervical spondylotic radiculopathy and preparation method thereof, its dosage form is unguentum, the invention belongs to Chinese medicine field.
Background technology
Cervical spondylosis claims again cervical spine syndrome, is the general name of osteoarthritis of cervical spine, proliferative cervical spondylosis, cervical syndrome, Cervical disc extrusion, is a kind ofly with degeneration pathology, to change into basic illness.Mainly due to cervical vertebra strain for a long time, hyperosteogeny, or prolapse of intervertebral disc, ligament thicken, and causes cervical vertebra spinal cord, nerve root or vertebral artery pressurized, occurs a series of handicapped clinical syndromes.Show as intervertebral disc degradation itself and insecondary a series of pathological change thereof, as vertebra joint unstability, loosening; Vertebral pulp is given prominence to or is deviate from; Bony spur forms; The spinal canal stenosis of ligament plumpness and secondary etc., stimulate or have oppressed the contiguous tissues such as nerve root, spinal cord, vertebral artery and cervical region sympathetic nerve, cause series of symptoms and sign.
Cervical spondylotic radiculopathy is because of due to one-sided or bilateral spinal nerve root irriate or pressurized, it shows as the sensation consistent with spinal nerve root areal area, motion and reflecting barrier, primary disease is more common, various non-operative treatment targetedly all have obvious curative effect, wherein especially with head and neck, continue (or interruption) traction, neck circumference braking and correct bad position effective.
The clinical symptoms of cervical spondylosis is comparatively complicated.Mainly contain nape pain, upper myasthenia of limbs, point numb, lower limb are weak, difficulty in walking, dizziness, feel sick, vomiting, even blurred vision, tachycardia and dysphagia etc.The clinical symptoms of cervical spondylosis and diseased region, organize involved and individual variation to have certain relation.
The clinical manifestation of cervical spondylotic radiculopathy: 1. neck symptom: weight differs depending on causing the reason difference of root pressurized.Mainly because of vertebral pulp outstanding due to person, because local hole nervi vertebralis is directly stimulated how with significantly cervical region pain, paravertebral muscles tenderness and the cervical region formula position of attentioning, cervical spine or interspinal direct tenderness or kowtow pain and mostly be positive, and these performances be take acute stage especially for obvious.As be the regression of pure uncovertebral joint and caused by hyperosteogeny person, neck symptom is slighter, even can be without special discovery.2. a property bitterly: the most common, its scope is consistent with the spinal nerve root distributed areas of the vertebra joint of getting involved.What bitterly accompany with root is other sensory disturbances of this nerve root areal area, wherein take numbness of the fingers, finger tip hyperesthesia and dermal sensation to go down etc. as common.3. a property muscular strength obstacle: the first pressurized person of former root be obviously, muscular hypertonia in early days, but weaken very soon and occur amyotrophy.Its scope of getting involved is also only confined to the flesh group that this spinal nerve root is arranged.At hand, take large and small thenar and interosseus as obviously.4. tendon reflex changes: the reflex arc that the spinal nerve root of getting involved participates in occurs abnormal.Early stage active, the intermediary and later stages go down or disappear, and during inspection, should compare with offside.The pathologic reflex that do not have of getting involved of simple root, as with pathologic reflex, represents that spinal cord gets involved simultaneously.
5. sign: the tractive test of all increase spinal nerve root tension force is mostly positive, especially acute stage and later root pressurized are main person.Cervical vertebra squeeze test positive be more common in take that vertebral pulp is outstanding, vertebral pulp is deviate from and vertebra joint unstable be main case, and because person due to hook vertebra hypertrophy is mostly the weak positive, because of Intraspinal Occupying Lesion institute causer, be mostly negative.
In the invention of existing treatment cervical spondylotic radiculopathy, Granted publication Granted publication CN 102526406 B(application numbers 201210039492.6) Chinese patent discloses a kind of Chinese medicinal plaster for the treatment of cervical spondylotic radiculopathy and preparation method thereof: Radix Astragali 20-40 part, Radix Angelicae Sinensis 10-25 part, Herba Epimedii 15-30 part, Colla cornus cervi 5-25 part, Radix Paeoniae Rubra 6-20 part, Ramulus Cinnamomi 6-20 part, Sanguis Draxonis 3-20 part, Herba Lycopodii 6-20 part, Semen Sinapis 6-20 part, Radix Notoginseng 6-20 part, 6-20 parts, Flos Carthami, Olibanum 6-20 part, Borneolum Syntheticum 3-13 part.Granted publication CN 101912539 B(application numbers 201010257525.5) Chinese patent discloses a kind of Chinese medicine composition that is used for the treatment of cervical spondylotic radiculopathy and preparation method thereof, formula and part by weight are A, take 10-50 weight portion Radix Angelicae Sinensis, 10-50 weight portion Rhizoma Chuanxiong and 6-35 weight portion Cortex Cinnamomi, after mixing, soak 1-3 hour, then distillating extracting oil at temperature 98-100 ℃, the β-cyclodextrin inclusion compound for volatile oil of collection, at temperature 50-60 ℃, stir 1-3 hour, place coolingly, after cold drying, be ground into fine powder, distillation remaining aqueous solution and medicinal residues are stand-by, B, respectively 10-50 weight portion Radix Notoginseng and 10-50 weight portion Rhizoma Gastrodiae powder are broken into fine powder, then they are mixed, soak again 1-3 hour, then decoct 1-2 hour, cooling rear filtration obtains filtrate and medicinal residues, these medicinal residues with in steps A) medicinal residues that obtain merge, after mixing with 10-50 weight portion Flos Carthami again, decoct with water 1-3 time, each 0.5-3 hour, filter, this merging filtrate and the filtrate obtaining above, steps A) the distillation remaining aqueous solution obtaining merges, carry out concentrating under reduced pressure again until at temperature 50-60 ℃ the clear paste of relative density 1.10-1.30, then drying under reduced pressure, be ground into fine powder, add 3-16 weight portion artificial Calculus Bovis, steps A) obtain β-cyclodextrin clathrate and dextrin, mix homogeneously.
Summary of the invention
For existing treatment present situation, one of object of the present invention is to provide a kind of plaster for the treatment of cervical spondylotic radiculopathy, not only there is Chinese medicine composition of the present invention and there is blood circulation promoting and blood stasis dispelling, warming the meridian understand things pain-stopping, also can be used for cervical spondylotic radiculopathy syndrome of static blood blocking collaterals, disease sees that neck and shoulder part is stiff, pain, Ipsilateral upper limbs walloping aches etc.
Another object of the present invention is just to provide the preparation method of the plaster of above-mentioned treatment cervical spondylotic radiculopathy.
Above-mentioned purpose of the present invention is achieved through the following technical solutions:
A kind of plaster for the treatment of cervical spondylotic radiculopathy, taking off the primary raw material of stating weight proportion is prepared from: Radix Puerariae 8-14 part, Herba Lycopodii 6-9 part, Rhizoma Dioscoreae Nipponicae 9-15 part, Rhizoma Et Radix Notopterygii 5-10 part, Rhizoma Wenyujin Concisum 4-11 part, Zaocys 7-13 part, Herba Pyrolae 6-15 part, Ramulus Uncariae Cum Uncis 6-9 part, Sedum aizoon L. 1-5 part, Squama Manis 1-9 part.
The plaster of above-mentioned treatment cervical spondylotic radiculopathy, preferred scheme, takes off the primary raw material of stating weight proportion and is prepared from: Radix Puerariae 10-12 part, Herba Lycopodii 7-8 part, Rhizoma Dioscoreae Nipponicae 11-13 part, Rhizoma Et Radix Notopterygii 6-8 part, Rhizoma Wenyujin Concisum 6-9 part, Zaocys 8-10 part, Herba Pyrolae 10-12 part, Ramulus Uncariae Cum Uncis 7-8 part, Sedum aizoon L. 2-4 part, Squama Manis 4-6 part.
The plaster of the above treatment cervical spondylotic radiculopathy, better preferred scheme, takes off the primary raw material of stating weight proportion and is prepared from: 11 parts of Radix Puerariaes, 7.5 parts of Herba Lycopodiis, 12 parts of Rhizoma Dioscoreae Nipponicae, 7 parts of Rhizoma Et Radix Notopterygiis, 8 parts of Rhizoma Wenyujin Concisum, 9 parts of Zaocyss, 11 parts of Herba Pyrolaes, 7.5 parts of Ramulus Uncariae Cum Uncis, 3 parts of Sedum aizoon L., 5 parts of Squama Maniss.
According to the preparation method of the plaster of arbitrary described treatment cervical spondylotic radiculopathy above, step is as follows:
1. Radix Puerariae, Herba Lycopodii, Rhizoma Dioscoreae Nipponicae, Rhizoma Et Radix Notopterygii, Rhizoma Wenyujin Concisum, Zaocys are placed in non iron container, add ethanol, the consumption of ethanol is 2 times of crude drug gross weight, and sealing is placed in the standing 1-10 days in shady and cool ventilation place, and filtration, obtains filtrate and filtering residue is standby;
2. step 1. in gained filtering residue add water, the consumption of water is 4 times of filtering residue consumption, and adds Sedum aizoon L., Herba Pyrolae, Ramulus Uncariae Cum Uncis, Squama Manis, intense fire is fried open, the fire of larding speech with literary allusions is decocted slowly, decocts to 30-50 minute, filters to get filtrate;
3. by step 1. in gained filtrate and step 2. in gained filtrate mix, standing 6-12 hour, filtration, filtrate is purified again by the way of distillation, obtains distillate standby;
4. in pot, add vegetable oil and rosin heating, do not stop to stir, to be mixedly add white vaseline to continue heated and stirred after evenly, excipient to be mixed is old tender when suitable, closes fire and is cooled to 60 ℃-80 ℃, add 3. middle gained distillate of step, after stirring, slow fire is endured slowly, after removal moisture, is cooled to 65 ℃, get 1-10g and spread upon in adhesive plaster or other substrate, make plaster.
According to above-mentioned preparation method, preferred scheme is: step 1. standing 3-8 days (preferably 5 days).
According to above-mentioned preparation method, preferred scheme is: 2. step decocts to 35-45 minute (preferably 40 minutes).
According to above-mentioned preparation method, preferred scheme is: step 3. standing 7-10 hour (preferably 9 hours).
According to above-mentioned preparation method, preferred scheme is: 4. step is closed fire and be cooled to 65 ℃-75 ℃ (preferably 70 ℃).
According to above-mentioned preparation method, preferred scheme is: the step 4. weight ratio of vegetable oil, Colophonium, white vaseline and distillate is 0.8:1.5:1.5:0.8.
Application according to the plaster of the treatment cervical spondylotic radiculopathy described in any one above when the medicine of preparation treatment cervical spondylotic myelopathy, cervical muscle myelopathy.
Best using method: for making the present invention reach best therapeutic effect, plaster is directly affixed on uncomfortable cervical vertebra place, gently seals about 1 minute with palm after subsides, and paste and wear 12 hours, every day 1 time, within 10 days, be a course for the treatment of.
Treat a plaster for cervical spondylotic radiculopathy, the pharmacological effect of each raw material is respectively:
Radix Puerariae: sweet in the mouth, pungent, cool in nature.Return spleen, stomach warp.Effect: expelling pathogenic factors from muscles for reducing heat, promote the production of body fluid, rash, yang invigorating antidiarrheal.Cure mainly: fever caused by exogenous pathogens headache, stiff nape and back, thirsty, quench one's thirst, measles without adequate eruption, hematodiarrhoea.
Herba Lycopodii: Herba Lycopodii, it is carefully cylindrical that stolon is, and slightly crooked, length can reach 2m, and diameter 1～3mm has yellow-white radicula under it.Erect stern is made two dichotomies.On Ye Misheng stem, helical arrangement, shrinkage is crooked, linear or aciculiform, long 3～5mm, yellow green is extremely fallow, without hair, tip aristiform, full edge, easily cataclasm.Matter is soft, and section skin zone is light yellow, woody part off-white color.Odorless, lightly seasoned.Toil temperature, enters Liver Channel.Expelling wind and cold. dehumidifying detumescence, relaxing muscles and tendons and activating QI and blood in the collateral.For anemofrigid-damp arthralgia, muscle arteries and veins contracture pain carbuncle.External is controlled osteopatia sprain and is swollen and ache.
Rhizoma Dioscoreae Nipponicae: return liver, kidney, lung meridian, warm in nature, sweet in the mouth, hardship.Relaxing muscles and tendons to promote blood circulation, relieving cough and resolving phlegm, wind-expelling pain-stopping.For lumbago and skelalgia, rheumatalgia, rheumatic arthritis, muscles and bones numbness, Kaschin-Beck disease, traumatic injury, sprain one's back, cough pant, tracheitis, bronchitis.
Rhizoma Et Radix Notopterygii: acrid in the mouth, hardship, warm in nature.Return bladder, kidney channel.Effect: cold expelling, dispel the wind, dehumidifying, pain relieving.Cure mainly: anemofrigid cold headache, rheumatic arthralgia, aching pain in should and back.
Rhizoma Wenyujin Concisum: acrid in the mouth, hardship, warm in nature.Return liver, spleen channel.Effect: removing blood stasis circulation of qi promoting, inducing menstruation to relieve menalgia.Cure mainly: amenorrhea due to stagnation of blood, menalgia, the twinge of the breast side of body, rheumatic arthralgia, shoulder arm pain, injury from falling down.
Zaocys: sweet in the mouth, property is flat.Return Liver Channel.Effect: dispel the wind, dredging collateral, relieving convulsion.Cure mainly: rheumatoid arthritis stubborn, numbness contracture, apoplexy facial hemiparalysis, hemiplegia, tic spasm, tetanus, leprosy scabies, scrofula malignant boil.
Herba Pyrolae: sweet in the mouth, hardship, warm in nature.Return liver, kidney channel.Effect: wind-damp dispelling, bone and muscle strengthening, hemostasis.Cure mainly: rheumatic arthralgia, weakness of the waist and knees, menorrhagia, chronic cough due to asthenia of viscera.
Ramulus Uncariae Cum Uncis: Ramulus Uncariae Cum Uncis sweet in the mouth, micro-hardship, cold nature; Return liver, pericardium channel; Hard the diving of matter fallen, and has heat clearing away suppressing the hyperactive liver, and the effect of relieving spasm by subduing liver-wind cures mainly liver-fire superinverse headache conjunctival congestion, and excessive rising of liver-YANG is had a dizzy spell, intenseness of heat wind symptom infantile convulsion, and infantile convulsion, night cry, eclamposia, paralysis due to windstroke, podomere contraction is anxious.
Sedum aizoon L.: the upright draft of perennial root, high approximately 15 centimetres.Root conico-acuminate.Basal leaf has long handle, the micro-band blush of light green, and the wealthy heart of blade or sub-circular, long 1～3 centimetre, wide 2～4.8 centimetres, there is shallow round cognate at edge.Spend single leave axil, pink colour band is yellow.Capsule.[nature and flavor] pungent fiber crops, temperature.[function cures mainly] promoting the flow of QI in the collateral by warming the meridian, stopping bleeding and knitting the fractured bone.External is controlled open fracture, is controlled traumatic hemorrhage.
Squama Manis: salty in the mouth, cold nature.Return liver, stomach warp.Effect: the stimulating milk secretion of stimulating the menstrual flow, detumescence and apocenosis, expel wind to dredge collateral.Cure mainly: amenorrhea and mass in the abdomen, galactostasis, carbuncle sore tumefacting virus, arthralgia, numbness contracture.
Colophonium, vegetable oil, white vaseline are excipient, play the effect of mediation figuration.
Plaster is one of the large dosage form-ball of Chinese medicine five, loose, cream, pellet, soup.Ancient doctor's speech is said: " plaster can be cured the disease, and not different from decoction, does in the proper way with it, and its sound is vertical should." prescription of the present invention all selects Xin Xiang to walk to go here and there extremely strong tying-in medicine, medicine directly infiltrates through skin, by interior transmission from one channel to another network, plays disperse blood stasis and dredge collateral, the effect that pain relieving is stimulated the menstrual flow.
The specific embodiment
Below in conjunction with embodiment and experimental example, describe technical scheme of the present invention in detail, but protection domain is not by this restriction.
embodiment 1treat a plaster for cervical spondylotic radiculopathy, take off the primary raw material of stating weight proportion and be prepared from (getting 15g for every part): 8 parts of Radix Puerariaes, 6 parts of Herba Lycopodiis, 9 parts of Rhizoma Dioscoreae Nipponicae, 5 parts of Rhizoma Et Radix Notopterygiis, 4 parts of Rhizoma Wenyujin Concisum, 7 parts of Zaocyss, 6 parts of Herba Pyrolaes, 6 parts of Ramulus Uncariae Cum Uncis, 1 part of Sedum aizoon L., 1 part of Squama Manis.
The preparation method of the plaster of above-mentioned treatment cervical spondylotic radiculopathy, step is:
1. Radix Puerariae, Herba Lycopodii, Rhizoma Dioscoreae Nipponicae, Rhizoma Et Radix Notopterygii, Rhizoma Wenyujin Concisum, Zaocys are placed in non iron container, add ethanol, the consumption of ethanol is 2 times of crude drug gross weight, and sealing is placed in shady and cool ventilation place standing 1 day, and filtration, obtains filtrate and filtering residue is standby;
2. step 1. in gained filtering residue add water, the consumption of water is 4 times of filtering residue consumption, and adds Sedum aizoon L., Herba Pyrolae, Ramulus Uncariae Cum Uncis, Squama Manis, intense fire is fried open, the fire of larding speech with literary allusions is decocted slowly, decocts to 30 minutes, filters to get filtrate;
3. by step 1. in gained filtrate and step 2. in gained filtrate mix, standing 6 hours, filtration, filtrate is purified again by the way of distillation, obtains distillate standby;
4. in pot, add vegetable oil and rosin heating, do not stop to stir, to be mixedly add white vaseline to continue heated and stirred after evenly, excipient to be mixed is old tender when suitable, closes fire and is cooled to 60 ℃, add 3. middle gained distillate of step, after stirring, slow fire is endured slowly, after removal moisture, is cooled to 65 ℃, get 1g and spread upon in adhesive plaster or other substrate, make plaster.
typical case onepoplar XX, man, 40 years old, Jinan, Shandong Province personage, the workman of certain factory.Recently half a year cervical region pain, paravertebral muscles tenderness, and lower limb have feeling of numbness, stiffly shake, do not have on foot unable, think at the beginning it is that work is tired, do not take notice of very much yet, but in nearest one month, cervical vertebra pain is severe, directly impact sleep and work, under layman's accompanying, to Jinan large hospital, check, check and find patient's restriction of neck motion, the pain increased in layback, and cervical region tenderness is obvious, there is trapezoidal change in x-ray plain film vertebra joint, is diagnosed as: cervical spondylotic radiculopathy.Under doctor's suggestion, bring into use the embodiment of the present invention 1 gained plaster.
Use the embodiment of the present invention 1 gained plaster, once a day, each subsides worn 12 hours in cervical pain place, within 10 days, is a course for the treatment of.Use 10 days, pain is obviously alleviated, and numb limbs and tense tendons sense makes moderate progress.Use 20 days, pain disappears substantially, and feeling of numbness is obviously alleviated, and has had strength on foot.Continue to use 10 days the recovery from illness of patient's self-induction.
embodiment 2treat a plaster for cervical spondylotic radiculopathy, take off the primary raw material of stating weight proportion and be prepared from (getting 10g for every part): 14 parts of Radix Puerariaes, 9 parts of Herba Lycopodiis, 15 parts of Rhizoma Dioscoreae Nipponicae, 10 parts of Rhizoma Et Radix Notopterygiis, 11 parts of Rhizoma Wenyujin Concisum, 13 parts of Zaocyss, 15 parts of Herba Pyrolaes, 9 parts of Ramulus Uncariae Cum Uncis, 5 parts of Sedum aizoon L., 9 parts of Squama Maniss.
The preparation method of the plaster of above-mentioned treatment cervical spondylotic radiculopathy, step is:
1. Radix Puerariae, Herba Lycopodii, Rhizoma Dioscoreae Nipponicae, Rhizoma Et Radix Notopterygii, Rhizoma Wenyujin Concisum, Zaocys are placed in non iron container, add ethanol, the consumption of ethanol is 2 times of crude drug gross weight, and sealing is placed in shady and cool ventilation place standing 10 days, and filtration, obtains filtrate and filtering residue is standby;
2. step 1. in gained filtering residue add water, the consumption of water is 4 times of filtering residue consumption, and adds Sedum aizoon L., Herba Pyrolae, Ramulus Uncariae Cum Uncis, Squama Manis, intense fire is fried open, the fire of larding speech with literary allusions is decocted slowly, decocts to 45 minutes, filters to get filtrate;
3. by step 1. in gained filtrate and step 2. in gained filtrate mix, standing 12 hours, filtration, filtrate is purified again by the way of distillation, obtains distillate standby;
4. in pot, add vegetable oil and rosin heating, do not stop to stir, to be mixedly add white vaseline to continue heated and stirred after evenly, excipient to be mixed is old tender when suitable, closes fire and is cooled to 80 ℃, add 3. middle gained distillate of step, after stirring, slow fire is endured slowly, after removal moisture, is cooled to 65 ℃, get 10g and spread upon in adhesive plaster or other substrate, make plaster.
typical case twocao XX, female, 52 years old, Weifang, Shandong personage.During last summer, accidentally drench with rain, conscious left side neck root after suffering from cold, shoulder and left upper arm pain, and extremity have slight feeling of numbness, originally do not take notice of, think just and suffered from cold, but before 1 month, there is urgent micturition in patient, frequent micturition, the symptom of constipation, child sees that mother is uncomfortable and is just with mother to check to hospital, check and find patient's Wry Neck, cervical region is tilted to the right limited, when cervical region rotates to the left, the pain increased, cervical region with do scapula position and all have obvious tenderness sense, X sheet shows the slight lateral bending of cervical flexure, be diagnosed as: cervical spondylotic radiculopathy, because patient does not want to spend the too many money of sons and daughters, doctor just suggestion uses embodiment 2 gained plaster.
Use the embodiment of the present invention 2 gained plaster, once a day, each subsides worn 12 hours, and cervical region and scapular region respectively paste one, within 10 days, are a course for the treatment of.Use 5 days, paste and wear the sensation that there is heating at position, feel well.Use 20 days, pain alleviates.Use 30 days, in the situation that noting posture and rest, substantially can avoid the generation of cervical pain symptom, omoplate place pain disappears completely, and cervical region can swing comparatively normally, and defecation is normal, and generation had no side effect between the operating period.
embodiment 3treat a plaster for cervical spondylotic radiculopathy, take off the primary raw material of stating weight proportion and be prepared from (getting 20g for every part): 10 parts of Radix Puerariaes, 7 parts of Herba Lycopodiis, 11 parts of Rhizoma Dioscoreae Nipponicae, 6 parts of Rhizoma Et Radix Notopterygiis, 6 parts of Rhizoma Wenyujin Concisum, 8 parts of Zaocyss, 10 parts of Herba Pyrolaes, 7 parts of Ramulus Uncariae Cum Uncis, 2 parts of Sedum aizoon L., 4 parts of Squama Maniss.
The preparation method of the plaster of above-mentioned treatment cervical spondylotic radiculopathy, step is:
1. Radix Puerariae, Herba Lycopodii, Rhizoma Dioscoreae Nipponicae, Rhizoma Et Radix Notopterygii, Rhizoma Wenyujin Concisum, Zaocys are placed in non iron container, add ethanol, the consumption of ethanol is 2 times of crude drug gross weight, and sealing is placed in shady and cool ventilation place standing 3 days, and filtration, obtains filtrate and filtering residue is standby;
2. step 1. in gained filtering residue add water, the consumption of water is 4 times of filtering residue consumption, and adds Sedum aizoon L., Herba Pyrolae, Ramulus Uncariae Cum Uncis, Squama Manis, intense fire is fried open, the fire of larding speech with literary allusions is decocted slowly, decocts to 35 minutes, filters to get filtrate;
3. by step 1. in gained filtrate and step 2. in gained filtrate mix, standing 7 hours, filtration, filtrate is purified again by the way of distillation, obtains distillate standby;
4. in pot, add vegetable oil and rosin heating, do not stop to stir, to be mixedly add white vaseline to continue heated and stirred after evenly, excipient to be mixed is old tender when suitable, closes fire and is cooled to 65 ℃, add 3. middle gained distillate of step, after stirring, slow fire is endured slowly, after removal moisture, is cooled to 65 ℃, get 3g and spread upon in adhesive plaster or other substrate, make plaster.
typical case threeopen XX, man, 60 years old, people from Qingzhou, Weifang City, peasant.Cervical spondylotic radiculopathy history 1 year, cervicodynia is uncomfortable in chest, and with the symptom of blurred vision, and right arm sensation grips unablely recently, and health has constrained sense, and all senses that couches night are uncomfortable, cannot fall asleep and cause lethargy.Check and find patient's instability of gait, hands grasping power is all not high, and right arm situation is even more serious, and compression of spinal cord is comparatively obvious, seeks medical advice everywhere, all to no effect, sees unintentionally plaster of the present invention on newspaper, has the attitude of trying in arms and has bought 2 courses for the treatment of.
Use the embodiment of the present invention 3 gained plaster, once a day, each subsides worn 12 hours, and cervical region and right arm scapular region respectively paste one, within 10 days, are a course for the treatment of.Use 10 days, nighttime sleep has clear improvement, and can fall asleep.Use 20 days, both hands have obvious strength high, and mental attitude is taken on a new look to some extent, and pain symptom alleviates.Use 30 days, pain obviously alleviates, and mental restoration is good, and vision is also recovered to some extent.Use 50 days, other malaise symptoms disappear substantially, the recovery from illness of patient's self-induction.
1,
embodiment 4treat a plaster for cervical spondylotic radiculopathy, take off the primary raw material of stating weight proportion and be prepared from (getting 25g for every part): 12 parts of Radix Puerariaes, 8 parts of Herba Lycopodiis, 13 parts of Rhizoma Dioscoreae Nipponicae, 8 parts of Rhizoma Et Radix Notopterygiis, 9 parts of Rhizoma Wenyujin Concisum, 10 parts of Zaocyss, 12 parts of Herba Pyrolaes, 8 parts of Ramulus Uncariae Cum Uncis, 4 parts of Sedum aizoon L., 6 parts of Squama Maniss.
The preparation method of the plaster of above-mentioned treatment cervical spondylotic radiculopathy, step is:
1. Radix Puerariae, Herba Lycopodii, Rhizoma Dioscoreae Nipponicae, Rhizoma Et Radix Notopterygii, Rhizoma Wenyujin Concisum, Zaocys are placed in non iron container, add ethanol, the consumption of ethanol is 2 times of crude drug gross weight, and sealing is placed in shady and cool ventilation place standing 8 days, and filtration, obtains filtrate and filtering residue is standby;
2. step 1. in gained filtering residue add water, the consumption of water is 4 times of filtering residue consumption, and adds Sedum aizoon L., Herba Pyrolae, Ramulus Uncariae Cum Uncis, Squama Manis, intense fire is fried open, the fire of larding speech with literary allusions is decocted slowly, decocts to 45 minutes, filters to get filtrate;
3. by step 1. in gained filtrate and step 2. in gained filtrate mix, standing 10 hours, filtration, filtrate is purified again by the way of distillation, obtains distillate standby;
4. in pot, add vegetable oil and rosin heating, do not stop to stir, to be mixedly add white vaseline to continue heated and stirred after evenly, excipient to be mixed is old tender when suitable, closes fire and is cooled to 75 ℃, add 3. middle gained distillate of step, after stirring, slow fire is endured slowly, after removal moisture, is cooled to 65 ℃, get 8g and spread upon in adhesive plaster or other substrate, make plaster.
embodiment 5treat a plaster for cervical spondylotic radiculopathy, take off the primary raw material of stating weight proportion and be prepared from (getting 30g for every part): 11 parts of Radix Puerariaes, 7.5 parts of Herba Lycopodiis, 12 parts of Rhizoma Dioscoreae Nipponicae, 7 parts of Rhizoma Et Radix Notopterygiis, 8 parts of Rhizoma Wenyujin Concisum, 9 parts of Zaocyss, 11 parts of Herba Pyrolaes, 7.5 parts of Ramulus Uncariae Cum Uncis, 3 parts of Sedum aizoon L., 5 parts of Squama Maniss.
The preparation method of the plaster of above-mentioned treatment cervical spondylotic radiculopathy, step is:
1. Radix Puerariae, Herba Lycopodii, Rhizoma Dioscoreae Nipponicae, Rhizoma Et Radix Notopterygii, Rhizoma Wenyujin Concisum, Zaocys are placed in non iron container, add ethanol, the consumption of ethanol is 2 times of crude drug gross weight, and sealing is placed in shady and cool ventilation place standing 5 days, and filtration, obtains filtrate and filtering residue is standby;
2. step 1. in gained filtering residue add water, the consumption of water is 4 times of filtering residue consumption, and adds Sedum aizoon L., Herba Pyrolae, Ramulus Uncariae Cum Uncis, Squama Manis, intense fire is fried open, the fire of larding speech with literary allusions is decocted slowly, decocts to 40 minutes, filters to get filtrate;
3. by step 1. in gained filtrate and step 2. in gained filtrate mix, standing 9 hours, filtration, filtrate is purified again by the way of distillation, obtains distillate standby;
4. in pot, add vegetable oil and rosin heating, do not stop to stir, to be mixedly add white vaseline to continue heated and stirred after evenly, excipient to be mixed is old tender when suitable, closes fire and is cooled to 70 ℃, add 3. middle gained distillate of step, after stirring, slow fire is endured slowly, after removal moisture, is cooled to 65 ℃, get 5g and spread upon in adhesive plaster or other substrate, make plaster.
experimental examplein order to verify the curative effect of the present invention to cervical spondylotic radiculopathy, chosen two or more person 200 people of cervical spondylotic radiculopathy symptom, the mean age is 40 years old, according to the state of an illness, be divided into two groups, experimental group and matched group, every group of 100 people, basically identical to guarantee two groups of situations.Experimental group is used embodiment 5 gained plaster, once a day, each subsides worn 12 hours, it within 10 days, is a course for the treatment of, matched group is used the Chinese medicine of other oral medication cervical spondylotic radiculopathyes, observes 30 days time limits, before experiment, first patient's symptom is comprehensively checked in 1 day, during experiment, regularly check inquiry patient body situation and impression, and make a record.
1, the curative effect of two groups of medicines is carried out to record, result is as following table 1.(criterion, effectively: the malaise symptoms being caused by cervical spondylotic radiculopathy has clear improvement; Invalid: the malaise symptoms being caused by cervical spondylotic radiculopathy is unchanged.）
Table 1:
analyze:as can be seen from Table 1, the present invention is 99% to the effective percentage of cervical spondylotic radiculopathy, exceeds matched group 19%, and effect is remarkable.
2, two groups of patient's applied mentals are changed and carry out record, result is as following table 2.
Table 2:
| Group | Number | Can consciously adhere to the number for the treatment of | There is no positive effect in a short time and produce psychological burden number | The number that life-time service can also be accepted |
| Experimental group | 100 | 100 | 1 | 99 |
| Matched group | 100 | 80 | 30 | 85 |
analyze:as can be seen from Table 2, medicament mode of the present invention more easily approved by patient, and major part represents per capita, Long-term taking medicine easily causes mental pressure, and can obviously affect appetite, external used medicine is favored by more people on therapeutic modality, is also more easy to accept and adhere to long-term treatment.Through can find out the analysis of many groups experimental data, plaster of the present invention is obvious for cervical spondylotic radiculopathy curative effect, and total effective rate is up to 99%, and without any side effects, can reach comparatively rapidly the effect of pain-alleviating and network vessel-freeing.On therapeutic modality, the present invention is also easier to the recognition and acceptance by patient, can lay a good foundation for later treatment.Chinese medicine composition of the present invention has been obtained significant effect in treatment cervical spondylotic radiculopathy, and stable curative effect, has no side effect, and is suitable for long-term taking.
Claims (10)
1. a plaster for the treatment of cervical spondylotic radiculopathy, it is characterized in that, take off the primary raw material of stating weight proportion and be prepared from: Radix Puerariae 8-14 part, Herba Lycopodii 6-9 part, Rhizoma Dioscoreae Nipponicae 9-15 part, Rhizoma Et Radix Notopterygii 5-10 part, Rhizoma Wenyujin Concisum 4-11 part, Zaocys 7-13 part, Herba Pyrolae 6-15 part, Ramulus Uncariae Cum Uncis 6-9 part, Sedum aizoon L. 1-5 part, Squama Manis 1-9 part.
2. the plaster for the treatment of cervical spondylotic radiculopathy according to claim 1, it is characterized in that, take off the primary raw material of stating weight proportion and be prepared from: Radix Puerariae 10-12 part, Herba Lycopodii 7-8 part, Rhizoma Dioscoreae Nipponicae 11-13 part, Rhizoma Et Radix Notopterygii 6-8 part, Rhizoma Wenyujin Concisum 6-9 part, Zaocys 8-10 part, Herba Pyrolae 10-12 part, Ramulus Uncariae Cum Uncis 7-8 part, Sedum aizoon L. 2-4 part, Squama Manis 4-6 part.
3. the plaster for the treatment of cervical spondylotic radiculopathy according to claim 1, it is characterized in that, take off the primary raw material of stating weight proportion and be prepared from: 11 parts of Radix Puerariaes, 7.5 parts of Herba Lycopodiis, 12 parts of Rhizoma Dioscoreae Nipponicae, 7 parts of Rhizoma Et Radix Notopterygiis, 8 parts of Rhizoma Wenyujin Concisum, 9 parts of Zaocyss, 11 parts of Herba Pyrolaes, 7.5 parts of Ramulus Uncariae Cum Uncis, 3 parts of Sedum aizoon L., 5 parts of Squama Maniss.
4. according to the preparation method of the plaster of the arbitrary described treatment cervical spondylotic radiculopathy of claim 1-3, it is characterized in that, step is as follows:
1. Radix Puerariae, Herba Lycopodii, Rhizoma Dioscoreae Nipponicae, Rhizoma Et Radix Notopterygii, Rhizoma Wenyujin Concisum, Zaocys are placed in non iron container, add ethanol, the consumption of ethanol is 2 times of crude drug gross weight, and sealing is placed in the standing 1-10 days in shady and cool ventilation place, and filtration, obtains filtrate and filtering residue is standby;
2. step 1. in gained filtering residue add water, the consumption of water is 4 times of filtering residue consumption, and adds Sedum aizoon L., Herba Pyrolae, Ramulus Uncariae Cum Uncis, Squama Manis, intense fire is fried open, the fire of larding speech with literary allusions is decocted slowly, decocts to 30-50 minute, filters to get filtrate;
3. by step 1. in gained filtrate and step 2. in gained filtrate mix, standing 6-12 hour, filtration, filtrate is purified again by the way of distillation, obtains distillate standby;
4. in pot, add vegetable oil and rosin heating, do not stop to stir, to be mixedly add white vaseline to continue heated and stirred after evenly, excipient to be mixed is old tender when suitable, closes fire and is cooled to 60 ℃-80 ℃, add 3. middle gained distillate of step, after stirring, slow fire is endured slowly, after removal moisture, is cooled to 65 ℃, get 1-10g and spread upon in adhesive plaster or other substrate, make plaster.
5. the preparation method of the plaster for the treatment of cervical spondylotic radiculopathy according to claim 4, is characterized in that, step 1. standing 3-8 days (preferably 5 days).
6. the preparation method of the plaster for the treatment of cervical spondylotic radiculopathy according to claim 4, is characterized in that, 2. step decocts to decocting to 35-45 minute (preferably 40 minutes).
7. the preparation method of the plaster for the treatment of cervical spondylotic radiculopathy according to claim 4, is characterized in that, step 3. standing 7-10 hour (preferably 9 hours).
8. the preparation method of the plaster for the treatment of cervical spondylotic radiculopathy according to claim 4, is characterized in that, 4. step is closed fire and be cooled to 65 ℃-75 ℃ (preferably 70 ℃).
9. the preparation method of the plaster for the treatment of cervical spondylotic radiculopathy according to claim 4, is characterized in that, the step 4. weight ratio of vegetable oil, Colophonium, white vaseline and distillate is 0.8:1.5:1.5:0.8.
10. the application when the medicine of cervical spondylotic myelopathy, cervical muscle myelopathy is treated in preparation according to the plaster of the treatment cervical spondylotic radiculopathy described in claim 1-3 any one.
Priority Applications (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610095638.7A CN105597021A (en) | 2014-04-28 | 2014-04-28 | Plaster for treating nerve-root type cervical spondylopathy |
| CN201610095640.4A CN105688041A (en) | 2014-04-28 | 2014-04-28 | Preparation method of plaster for treating cervical spondylotic radiculopathy |
| CN201610095639.1A CN105688040A (en) | 2014-04-28 | 2014-04-28 | Plaster for treating cervical spondylotic radiculopathy |
| CN201410173689.8A CN103948863B (en) | 2014-04-28 | 2014-04-28 | A kind of plaster for the treatment of nerve root cervical vertebra sickness and preparation method thereof |
| CN201610095636.8A CN105561207A (en) | 2014-04-28 | 2014-04-28 | Medicine composition for treating nerve-root type cervical spondylosis |
| CN201610095637.2A CN105561208A (en) | 2014-04-28 | 2014-04-28 | Traditional Chinese medicine unguent for treating cervical spondylotic radiculopathy |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410173689.8A CN103948863B (en) | 2014-04-28 | 2014-04-28 | A kind of plaster for the treatment of nerve root cervical vertebra sickness and preparation method thereof |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610095637.2A Division CN105561208A (en) | 2014-04-28 | 2014-04-28 | Traditional Chinese medicine unguent for treating cervical spondylotic radiculopathy |
| CN201610095638.7A Division CN105597021A (en) | 2014-04-28 | 2014-04-28 | Plaster for treating nerve-root type cervical spondylopathy |
| CN201610095636.8A Division CN105561207A (en) | 2014-04-28 | 2014-04-28 | Medicine composition for treating nerve-root type cervical spondylosis |
| CN201610095639.1A Division CN105688040A (en) | 2014-04-28 | 2014-04-28 | Plaster for treating cervical spondylotic radiculopathy |
| CN201610095640.4A Division CN105688041A (en) | 2014-04-28 | 2014-04-28 | Preparation method of plaster for treating cervical spondylotic radiculopathy |
Publications (2)
| Publication Number | Publication Date |
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| CN103948863A true CN103948863A (en) | 2014-07-30 |
| CN103948863B CN103948863B (en) | 2016-05-11 |
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| CN201610095640.4A Pending CN105688041A (en) | 2014-04-28 | 2014-04-28 | Preparation method of plaster for treating cervical spondylotic radiculopathy |
| CN201610095639.1A Withdrawn CN105688040A (en) | 2014-04-28 | 2014-04-28 | Plaster for treating cervical spondylotic radiculopathy |
| CN201610095638.7A Withdrawn CN105597021A (en) | 2014-04-28 | 2014-04-28 | Plaster for treating nerve-root type cervical spondylopathy |
| CN201610095636.8A Withdrawn CN105561207A (en) | 2014-04-28 | 2014-04-28 | Medicine composition for treating nerve-root type cervical spondylosis |
| CN201410173689.8A Active CN103948863B (en) | 2014-04-28 | 2014-04-28 | A kind of plaster for the treatment of nerve root cervical vertebra sickness and preparation method thereof |
| CN201610095637.2A Withdrawn CN105561208A (en) | 2014-04-28 | 2014-04-28 | Traditional Chinese medicine unguent for treating cervical spondylotic radiculopathy |
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| CN201610095640.4A Pending CN105688041A (en) | 2014-04-28 | 2014-04-28 | Preparation method of plaster for treating cervical spondylotic radiculopathy |
| CN201610095639.1A Withdrawn CN105688040A (en) | 2014-04-28 | 2014-04-28 | Plaster for treating cervical spondylotic radiculopathy |
| CN201610095638.7A Withdrawn CN105597021A (en) | 2014-04-28 | 2014-04-28 | Plaster for treating nerve-root type cervical spondylopathy |
| CN201610095636.8A Withdrawn CN105561207A (en) | 2014-04-28 | 2014-04-28 | Medicine composition for treating nerve-root type cervical spondylosis |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104306536A (en) * | 2014-09-27 | 2015-01-28 | 王纬 | A plaster for treating nerve-root type cervical spondylosis and a preparing method thereof |
| CN104491072A (en) * | 2015-01-04 | 2015-04-08 | 霍山县中医院 | Traditional Chinese medicine for treating nerve-root type cervical spondylosis |
| CN104706793A (en) * | 2015-02-25 | 2015-06-17 | 黄桂荣 | Traditional Chinese medicine anaesthesia pain relieving tincture for treating nerve-root type cervical spondylosis |
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| CN1090771A (en) * | 1993-02-12 | 1994-08-17 | 武秋华 | Medicine " Yuntongling " for treating dizziness and headache |
| CN1416837A (en) * | 2001-11-08 | 2003-05-14 | 纪玉田 | Bone Bi-syndrome treating pill |
| CN101129973A (en) * | 2006-08-25 | 2008-02-27 | 范广友 | Traditional Chinese medicine for treating cervical vertebra disease |
| CN103070994A (en) * | 2013-02-17 | 2013-05-01 | 马云波 | Plaster for treating cervical and lumbar spondylosis |
| CN103083609A (en) * | 2011-10-28 | 2013-05-08 | 刘亚芝 | Traditional Chinese medicine for treating cervical spondylosis, lumbar intervertebral disc herniation and ankylosing spondylitis |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN101721660A (en) * | 2008-10-22 | 2010-06-09 | 张彬 | Plaster for curing cervical spondylosis |
| CN101926969B (en) * | 2010-06-03 | 2014-06-25 | 陕西中医学院 | Traditional Chinese medicine composition for treatment of cervical spondylopathy and preparation method thereof |
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2014
- 2014-04-28 CN CN201610095640.4A patent/CN105688041A/en active Pending
- 2014-04-28 CN CN201610095639.1A patent/CN105688040A/en not_active Withdrawn
- 2014-04-28 CN CN201610095638.7A patent/CN105597021A/en not_active Withdrawn
- 2014-04-28 CN CN201610095636.8A patent/CN105561207A/en not_active Withdrawn
- 2014-04-28 CN CN201410173689.8A patent/CN103948863B/en active Active
- 2014-04-28 CN CN201610095637.2A patent/CN105561208A/en not_active Withdrawn
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1090771A (en) * | 1993-02-12 | 1994-08-17 | 武秋华 | Medicine " Yuntongling " for treating dizziness and headache |
| CN1416837A (en) * | 2001-11-08 | 2003-05-14 | 纪玉田 | Bone Bi-syndrome treating pill |
| CN101129973A (en) * | 2006-08-25 | 2008-02-27 | 范广友 | Traditional Chinese medicine for treating cervical vertebra disease |
| CN103083609A (en) * | 2011-10-28 | 2013-05-08 | 刘亚芝 | Traditional Chinese medicine for treating cervical spondylosis, lumbar intervertebral disc herniation and ankylosing spondylitis |
| CN103070994A (en) * | 2013-02-17 | 2013-05-01 | 马云波 | Plaster for treating cervical and lumbar spondylosis |
Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104306536A (en) * | 2014-09-27 | 2015-01-28 | 王纬 | A plaster for treating nerve-root type cervical spondylosis and a preparing method thereof |
| CN104491072A (en) * | 2015-01-04 | 2015-04-08 | 霍山县中医院 | Traditional Chinese medicine for treating nerve-root type cervical spondylosis |
| CN104706793A (en) * | 2015-02-25 | 2015-06-17 | 黄桂荣 | Traditional Chinese medicine anaesthesia pain relieving tincture for treating nerve-root type cervical spondylosis |
Also Published As
| Publication number | Publication date |
|---|---|
| CN105688041A (en) | 2016-06-22 |
| CN105561208A (en) | 2016-05-11 |
| CN105688040A (en) | 2016-06-22 |
| CN105597021A (en) | 2016-05-25 |
| CN103948863B (en) | 2016-05-11 |
| CN105561207A (en) | 2016-05-11 |
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Effective date of registration: 20160413 Address after: 342200 Wenfeng Industrial Park, Xunwu, Jiangxi, Ganzhou Applicant after: JIANGXI DIKANG PHARMACEUTICAL Co.,Ltd. Address before: 250000 Ji'nan, Licheng District, Sun Village, white Valley heap No. two District No. 103 Applicant before: Guo Ruying |
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Denomination of invention: A plaster for treating cervical spondylosis of nerve root type and its preparation method Effective date of registration: 20221219 Granted publication date: 20160511 Pledgee: Agricultural Bank of China Limited Xunwu County Sub branch Pledgor: JIANGXI DIKANG PHARMACEUTICAL Co.,Ltd. Registration number: Y2022980028160 |