CN103948863B - A kind of plaster for the treatment of nerve root cervical vertebra sickness and preparation method thereof - Google Patents
A kind of plaster for the treatment of nerve root cervical vertebra sickness and preparation method thereof Download PDFInfo
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- CN103948863B CN103948863B CN201410173689.8A CN201410173689A CN103948863B CN 103948863 B CN103948863 B CN 103948863B CN 201410173689 A CN201410173689 A CN 201410173689A CN 103948863 B CN103948863 B CN 103948863B
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- cervical vertebra
- nerve root
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- A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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Abstract
The invention discloses a kind of plaster for the treatment of nerve root cervical vertebra sickness and preparation method thereof, mainly taking off the raw material of stating weight proportion is prepared from: root of kudzu vine 8-14 part, lycopodium calvatum 6-9 part, rhizoma dioscoreae nipponicae 9-15 part, notopterygium root 5-10 part, rhizoma curcumae longae concisa 4-11 part, zaocys dhumnade 7-13 part, pyrola 6-15 part, yncaria stem with hooks 6-9 part, asiatic toddalia root-bark 1-5 part, pangolin 1-9 part. The present invention has the dysmenorrhoea of invigorating blood circulation, and the effect of pain-alleviating and network vessel-freeing has good result for the treatment of to nerve root cervical vertebra sickness and complication thereof.
Description
Technical field
The invention discloses a kind of plaster for the treatment of nerve root cervical vertebra sickness and preparation method thereof, its formulation is paste, the invention belongs to traditional Chinese medicine field.
Background technology
Cervical spondylopathy claims again cervical spine syndrome, is the general name of osteoarthritis of cervical spine, proliferative cervical spondylosis, cervical syndrome, Cervical disc extrusion, is a kind ofly to change into basic illness with degeneration pathology. Mainly due to cervical vertebra strain for a long time, osteoproliferation, or interverbebral disc is deviate from, ligament thickens, and causes cervical vertebra spinal cord, nerve root or vertebral artery pressurized, occurs a series of handicapped clinical syndromes. Show as intervertebral disc degradation itself and insecondary a series of pathological change thereof, as vertebra joint unstability, loosening; Nucleus pulposus is given prominence to or is deviate from; Spur forms; The spinal canal stenosis of ligament plumpness and secondary etc., stimulate or have oppressed the tissues such as contiguous nerve root, spinal cord, vertebral artery and neck sympathetic nerve, cause series of symptoms and sign.
Nerve root cervical vertebra sickness is because of due to one-sided or bilateral spinal nerve root irriate or pressurized, it shows as the sensation consistent with spinal nerve root distributed area, motion and reflecting barrier, this disease is more common, various non-operative treatment targetedly all have obvious curative effect, wherein especially continue (or interruption) traction, neck circumference braking and correct bad position effective with neck.
The clinical symptoms of cervical spondylopathy are comparatively complicated. Mainly contain nape pain, upper myasthenia of limbs, point numb, lower limb are weak, difficulty in walking, dizziness, feel sick, vomiting, even blurred vision, tachycardia and dysphagia etc. The clinical symptoms of cervical spondylopathy and diseased region, organize involved and individual difference to have certain relation.
The clinical manifestation of nerve root cervical vertebra sickness: 1. neck symptom: weight differs depending on causing the reason difference of root pressurized. Mainly because of nucleus pulposus outstanding due to person, because local hole nervi vertebralis is directly stimulated how with significantly neck pain, paravertebral muscles tenderness and the neck formula position of attentioning, cervical spine or interspinal direct tenderness or kowtow pain and mostly be positive, and these performances especially taking acute stage for obvious. As be the regression of pure uncovertebral joint and caused by hyperosteogeny person, neck symptom is slighter, even can be without special discovery. 2. a property pain: the most common, its scope is consistent with the spinal nerve root distributed areas of the vertebra joint of getting involved. What accompany with root pain is other sensory disturbances in this nerve root distributed area, wherein goes down etc. as common taking the numbness of fingers, finger tip hyperesthesia and dermal sensation. 3. a property muscular strength obstacle: the first pressurized person of former root be obviously, hypermyotonia in early days, but weaken very soon and occur amyotrophia. Its scope of getting involved is also only confined to the flesh group that this spinal nerve root is arranged. At hand taking large and small thenar and interosseus as obviously. 4. tendon reflex changes: the reflex arc that the spinal nerve root of getting involved participates in occurs abnormal. Early stage active, the intermediary and later stages go down or disappear, and when inspection, should compare with offside. The pathologic reflex that do not have of getting involved of simple root, as with pathologic reflex, represents that spinal cord gets involved simultaneously.
5. sign: the tractive test of all increase spinal nerve root tension force is mostly positive, especially acute stage and later root pressurized are main person. That cervical vertebra squeeze test positive is more common in is outstanding taking nucleus pulposus, nucleus pulposus is deviate from and vertebra joint unstable be main case, and because person due to hook vertebra hyperplasia is mostly the weak positive, because of Intraspinal Occupying Lesion institute causer, be mostly negative.
In the invention of existing treatment nerve root cervical vertebra sickness, Granted publication Granted publication CN102526406B(application number 201210039492.6) Chinese patent a kind of Chinese medicinal plaster for the treatment of nerve root cervical vertebra sickness and preparation method thereof is disclosed: Radix Astragali 20-40 part, Radix Angelicae Sinensis 10-25 part, barrenwort 15-30 part, deer horn glue 5-25 part, radix paeoniae rubrathe 6-20 part, cassia twig 6-20 part, dragon's blood exhaust 3-20 part, lycopodium calvatum 6-20 part, mustard seed 6-20 part, pseudo-ginseng 6-20 part, safflower 6-20 part, frankincense 6-20 part, borneol 3-13 part. Granted publication CN101912539B(application number 201010257525.5) Chinese patent a kind of Chinese medicine composition that is used for the treatment of nerve root cervical vertebra sickness and preparation method thereof is disclosed, formula and part by weight are A, take 10-50 weight portion Radix Angelicae Sinensis, 10-50 weight portion Ligusticum wallichii and 6-35 weight portion Chinese cassia tree, after mixing, soak 1-3 hour, then distillating extracting oil at temperature 98-100 DEG C, the volatile oil beta-cyclodextrin inclusion compound of collection, at temperature 50-60 DEG C, stir 1-3 hour, place coolingly, after low temperature drying, be ground into fine powder, distillation remaining aqueous solution and the dregs of a decoction are stand-by, B, respectively 10-50 weight portion pseudo-ginseng and 10-50 weight portion Rhizoma Gastrodiae powder are broken into fine powder, then they are mixed, soak again 1-3 hour, then decoct 1-2 hour, cooling rear filtration obtains filtrate and the dregs of a decoction, these dregs of a decoction with in steps A) dregs of a decoction that obtain merge, boiling 1-3 time after mixing with 10-50 weight portion safflower again, each 0.5-3 hour, filter, this merging filtrate and the filtrate obtaining above, steps A) the distillation remaining aqueous solution that obtains merges, carry out reduced pressure concentration again until at temperature 50-60 DEG C the clear cream of relative density 1.10-1.30, then drying under reduced pressure, be ground into fine powder, add 3-16 weight portion calculus bovis factitius, steps A) obtain Benexate Hydrochloride and dextrin, mix.
Summary of the invention
For existing treatment present situation, one of object of the present invention is to provide a kind of plaster for the treatment of nerve root cervical vertebra sickness, not only having Chinese medicine composition of the present invention has promoting blood circulation and removing blood stasis, temperature is through understand things pain-stopping, also can be used for nerve root cervical vertebra sickness syndrome of static blood blocking collaterals, disease sees that neck and shoulder part is stiff, pain, Ipsilateral upper limbs walloping aches etc.
Another object of the present invention is just to provide the preparation method of the plaster of above-mentioned treatment nerve root cervical vertebra sickness.
Above-mentioned purpose of the present invention is achieved through the following technical solutions:
A kind of plaster for the treatment of nerve root cervical vertebra sickness, taking off the primary raw material of stating weight proportion is prepared from: root of kudzu vine 8-14 part, lycopodium calvatum 6-9 part, rhizoma dioscoreae nipponicae 9-15 part, notopterygium root 5-10 part, rhizoma curcumae longae concisa 4-11 part, zaocys dhumnade 7-13 part, pyrola 6-15 part, yncaria stem with hooks 6-9 part, asiatic toddalia root-bark 1-5 part, pangolin 1-9 part.
The plaster of above-mentioned treatment nerve root cervical vertebra sickness, preferred scheme, takes off the primary raw material of stating weight proportion and is prepared from: root of kudzu vine 10-12 part, lycopodium calvatum 7-8 part, rhizoma dioscoreae nipponicae 11-13 part, notopterygium root 6-8 part, rhizoma curcumae longae concisa 6-9 part, zaocys dhumnade 8-10 part, pyrola 10-12 part, yncaria stem with hooks 7-8 part, asiatic toddalia root-bark 2-4 part, pangolin 4-6 part.
The plaster of the above treatment nerve root cervical vertebra sickness, better preferred scheme, takes off the primary raw material of stating weight proportion and is prepared from: 11 parts of the roots of kudzu vine, 7.5 parts of lycopodium calvatums, 12 parts of rhizoma dioscoreae nipponicaes, 7 parts of notopterygium roots, 8 parts of rhizoma curcumae longae concisas, 9 parts of zaocys dhumnades, 11 parts of pyrolas, 7.5 parts of yncaria stems with hooks, 3 parts of asiatic toddalia root-barks, 5 parts of pangolins.
According to the preparation method of the plaster of arbitrary described treatment nerve root cervical vertebra sickness above, step is as follows:
1. the root of kudzu vine, lycopodium calvatum, rhizoma dioscoreae nipponicae, notopterygium root, rhizoma curcumae longae concisa, zaocys dhumnade are placed in non iron container, add ethanol, the consumption of ethanol is 2 times of bulk drug gross weight, and sealing is placed in shady and cool ventilation place and leaves standstill 1-10 days, and filtration, obtains filtrate and filter residue is for subsequent use;
2. step 1. in gained filter residue add water, the consumption of water is 4 times of filter residue consumption, and adds asiatic toddalia root-bark, pyrola, yncaria stem with hooks, pangolin, intense fire is fried open, the fire of larding speech with literary allusions is decocted slowly, decocts to 30-50 minute, filters to get filtrate;
3. by step 1. in gained filtrate and step 2. in gained filtrate mixes, standing 6-12 hour, filtration, filtrate is purified again by the way of distillation, obtains distillate for subsequent use;
4. in pot, add vegetable oil and rosin heating, do not stop to stir, to be mixedly add albolene to continue to add thermal agitation after evenly, excipient to be mixed is old tender when suitable, closes fire and is cooled to 60 DEG C-80 DEG C, add 3. middle gained distillate of step, after stirring, slow fire is endured slowly, after removal moisture, is cooled to 65 DEG C, get 1-10g and spread upon in adhesive plaster or other matrix, make plaster.
According to above-mentioned preparation method, preferred scheme is: 1. step leaves standstill 3-8 days (preferably 5 days).
According to above-mentioned preparation method, preferred scheme is: 2. step decocts to 35-45 minute (preferably 40 minutes).
According to above-mentioned preparation method, preferred scheme is: 3. step leaves standstill 7-10 hour (preferably 9 hours).
According to above-mentioned preparation method, preferred scheme is: 4. step is closed fire and be cooled to 65 DEG C-75 DEG C (preferably 70 DEG C).
According to above-mentioned preparation method, preferred scheme is: the step 4. weight ratio of vegetable oil, rosin, albolene and distillate is 0.8:1.5:1.5:0.8.
Application according to the plaster of the treatment nerve root cervical vertebra sickness described in any one above when the medicine of preparation treatment cervical spondylotic myelopathy, cervical muscle myelopathy.
Best using method: for making the present invention reach best result for the treatment of, plaster is directly affixed on uncomfortable cervical vertebra place, gently seals about 1 minute with palm after subsides, and paste and wear 12 hours, every day 1 time, within 10 days, be a course for the treatment of.
Treat a plaster for nerve root cervical vertebra sickness, the pharmacological effect of each raw material is respectively:
The root of kudzu vine: taste is sweet, pungent, cool in nature. Return spleen, stomach warp. Effect: relieving muscles to expel heat, to promote the production of body fluid, promoting eruption, rises positive antidiarrheal. Cure mainly: fever caused by exogenous pathogens headache, stiff nape and back, thirsty, quench one's thirst, measles without adequate eruption, hot dysentery.
Lycopodium calvatum: lycopodium calvatum, it is carefully cylindrical that stolon is, and slightly bending, length can reach 2m, and diameter 1～3mm has yellow-white radicula under it. Erect stern is made two dichotomies. On Ye Misheng stem, helical arrangement, shrinkage bending, linear or aciculiform, long 3～5mm, yellow green is extremely fallow, without hair, tip aristiform, Quan Yuan, easily cataclasm. Matter softness, section skin zone is light yellow, woody part off-white color. Odorless, lightly seasoned. Toil temperature, enters Liver Channel. Expelling wind and clearing away cold. dehumidifying detumescence, stimulate the circulation of the blood and cause the muscles and joints to relax. For wind-cold-dampness arthralgia, muscle arteries and veins contraction pain carbuncle. External application is controlled osteopatia sprain and is swollen and ache.
Rhizoma dioscoreae nipponicae: return liver, kidney, lung channel, warm in nature, taste is sweet, bitter. Relax the muscles and stimulate the blood circulation, relieving cough and reducing sputum, wind-expelling pain-stopping. For lumbocrural pain, rheumatalgia, rheumatic arthritis, muscles and bones numbness, Kaschin-Beck disease, traumatic injury, sprain one's back, cough pant, tracheitis, bronchitis.
Notopterygium root: taste is pungent, bitter, warm in nature. Return bladder, kidney channel. Effect: loose cold, dispel the wind, dehumidifying, pain relieving. Cure mainly: anemofrigid cold headache, arthralgia due to wind-dampness, aching pain in should and back.
Rhizoma curcumae longae concisa: taste is pungent, bitter, warm in nature. Return liver, the spleen channel. Effect: broken blood gas, inducing meastruation to relieve menalgia. Cure mainly: amenorrhea due to stagnation of blood, menalgia, the shouting pain of the chest side of body, arthralgia due to wind-dampness, shoulder arm pain, injury from falling down.
Zaocys dhumnade: taste is sweet, property is flat. Return Liver Channel. Effect: dispel the wind, dredging collateral, only convulsion. Cure mainly: rheumatoid arthritis stubborn, numbness contracture, apoplexy facial paralysis, hemiplegia, tic spasm, lockjaw, leprosy mange, scrofula is disliked sore.
Pyrola: taste is sweet, bitter, warm in nature. Return liver, kidney channel. Effect: wines used as antirheumatic, strengthening the bones and muscles, hemostasis. Cure mainly: arthralgia due to wind-dampness, waist-leg weakness, menorrhalgia, chronic cough due to asthenia of viscera.
Yncaria stem with hooks: sweet, the micro-hardship of yncaria stem with hooks taste, cold nature; Return liver, pericardium channel; Hard the diving of matter fallen, and has the flat liver of heat-clearing, and effect of relieving convulsion and spasm cures mainly irascibility superinverse headache hot eyes, and liver-yang hyperactivity is had a dizzy spell, and heat is contained the frightened epilepsy of moving wind, child convulsion, and the morbid night crying of babies, eclampsia, paralysis due to windstroke, podomere contraction is anxious.
Asiatic toddalia root-bark: the upright draft of perennial root, high approximately 15 centimetres. Root conico-acuminate. Basal leaf has long handle, the micro-band blush of light green, and the wealthy heart of blade or sub-circular, long 1～3 centimetre, wide 2～4.8 centimetres, there is shallow round cognate at edge. Spend single leave armpit, pink colour band Huang. Capsule. [nature and flavor] pungent fiber crops, temperature. [function cures mainly] warming and activating meridian, stop bleeding and knit the fractured bone. External application is controlled open fracture, is controlled traumatism and bleeding.
Pangolin: taste is salty, cold nature. Return liver, stomach warp. Effect: the lactogenesis of stimulating the menstrual flow, detumescence and apocenosis, expel wind to dredge collateral. Cure mainly: Jing Bi Disorder lump in the abdomen, alactation, carbuncle sore tumefacting virus, joint pain, numbness contracture.
Rosin, vegetable oil, albolene are excipient, play the effect of mediation figuration.
Plaster is one of the large formulation-ball of Chinese medicine five, loose, cream, pellet, soup. Ancient doctor's speech is said: " plaster can be cured the disease, and not different from decoction of medicinal ingredients is done in the proper way with it, and its sound is vertical should. " prescription of the present invention all selects Xin Xiang to walk to go here and there extremely strong tying-in medicine, medicine directly infiltrates through skin, by interior transmission from one channel to another network, plays disperse blood stasis and dredge collateral, the effect that pain relieving is stimulated the menstrual flow.
Detailed description of the invention
Describe technical scheme of the present invention in detail below in conjunction with embodiment and experimental example, but protection domain is not by this restriction.
Embodiment 1Treat a plaster for nerve root cervical vertebra sickness, take off the primary raw material of stating weight proportion and be prepared from (getting 15g for every part): 8 parts of the roots of kudzu vine, 6 parts of lycopodium calvatums, 9 parts of rhizoma dioscoreae nipponicaes, 5 parts of notopterygium roots, 4 parts of rhizoma curcumae longae concisas, 7 parts of zaocys dhumnades, 6 parts of pyrolas, 6 parts of yncaria stems with hooks, 1 part of asiatic toddalia root-bark, 1 part of pangolin.
The preparation method of the plaster of above-mentioned treatment nerve root cervical vertebra sickness, step is:
1. the root of kudzu vine, lycopodium calvatum, rhizoma dioscoreae nipponicae, notopterygium root, rhizoma curcumae longae concisa, zaocys dhumnade are placed in non iron container, add ethanol, the consumption of ethanol is 2 times of bulk drug gross weight, and sealing is placed in shady and cool ventilation place and leaves standstill 1 day, and filtration, obtains filtrate and filter residue is for subsequent use;
2. step 1. in gained filter residue add water, the consumption of water is 4 times of filter residue consumption, and adds asiatic toddalia root-bark, pyrola, yncaria stem with hooks, pangolin, intense fire is fried open, the fire of larding speech with literary allusions is decocted slowly, decocts to 30 minutes, filters to get filtrate;
3. by step 1. in gained filtrate and step 2. in gained filtrate mixes, standing 6 hours, filtration, filtrate is purified again by the way of distillation, obtains distillate for subsequent use;
4. in pot, add vegetable oil and rosin heating, do not stop to stir, to be mixedly add albolene to continue to add thermal agitation after evenly, excipient to be mixed is old tender when suitable, closes fire and is cooled to 60 DEG C, add 3. middle gained distillate of step, after stirring, slow fire is endured slowly, after removal moisture, is cooled to 65 DEG C, get 1g and spread upon in adhesive plaster or other matrix, make plaster.
Typical case onePoplar XX, man, 40 years old, Jinan, Shandong Province personage, the workman of certain factory. Recently half a year neck pain, paravertebral muscles tenderness, and lower limb have feeling of numbness, stiffly shake, do not have on foot unable, think at the beginning it is that work is tired, do not take notice of very much yet, but in nearest one month, cervical vertebra pain severity, directly impact sleep and work, under layman's accompanying, check to Jinan large hospital, check and find patient's neck limitation of activity, the pain increased in layback, and neck tenderness is obvious, there is trapezoidal change in x-ray plain film vertebra joint, is diagnosed as: nerve root cervical vertebra sickness. Under doctor's suggestion, bring into use the embodiment of the present invention 1 gained plaster.
Use the embodiment of the present invention 1 gained plaster, once a day, each subsides worn 12 hours in cervical pain place, within 10 days, is a course for the treatment of. Use 10 days, pain is obviously alleviated, and extremity numbness sense makes moderate progress. Use 20 days, pain disappears substantially, and feeling of numbness is obviously alleviated, and has had strength on foot. Continue to use 10 days the recovery from illness of patient's self-induction.
Embodiment 2Treat a plaster for nerve root cervical vertebra sickness, take off the primary raw material of stating weight proportion and be prepared from (getting 10g for every part): 14 parts of the roots of kudzu vine, 9 parts of lycopodium calvatums, 15 parts of rhizoma dioscoreae nipponicaes, 10 parts of notopterygium roots, 11 parts of rhizoma curcumae longae concisas, 13 parts of zaocys dhumnades, 15 parts of pyrolas, 9 parts of yncaria stems with hooks, 5 parts of asiatic toddalia root-barks, 9 parts of pangolins.
The preparation method of the plaster of above-mentioned treatment nerve root cervical vertebra sickness, step is:
1. the root of kudzu vine, lycopodium calvatum, rhizoma dioscoreae nipponicae, notopterygium root, rhizoma curcumae longae concisa, zaocys dhumnade are placed in non iron container, add ethanol, the consumption of ethanol is 2 times of bulk drug gross weight, and sealing is placed in shady and cool ventilation place and leaves standstill 10 days, and filtration, obtains filtrate and filter residue is for subsequent use;
2. step 1. in gained filter residue add water, the consumption of water is 4 times of filter residue consumption, and adds asiatic toddalia root-bark, pyrola, yncaria stem with hooks, pangolin, intense fire is fried open, the fire of larding speech with literary allusions is decocted slowly, decocts to 45 minutes, filters to get filtrate;
3. by step 1. in gained filtrate and step 2. in gained filtrate mixes, standing 12 hours, filtration, filtrate is purified again by the way of distillation, obtains distillate for subsequent use;
4. in pot, add vegetable oil and rosin heating, do not stop to stir, to be mixedly add albolene to continue to add thermal agitation after evenly, excipient to be mixed is old tender when suitable, closes fire and is cooled to 80 DEG C, add 3. middle gained distillate of step, after stirring, slow fire is endured slowly, after removal moisture, is cooled to 65 DEG C, get 10g and spread upon in adhesive plaster or other matrix, make plaster.
Typical case twoCao XX, female, 52 years old, Weifang, Shandong personage. when last summer, accidentally drench with rain, conscious left side neck root after suffering from cold, shoulder and left upper arm pain, and four limbs have slight feeling of numbness, originally do not take notice of, think just and suffered from cold, but before 1 month, there is urgent urination in patient, frequent micturition, the symptom of constipation, child sees that mother is uncomfortable and is just with mother to check to hospital, check and find patient's Wry Neck, neck is tilted to the right limited, when neck rotates to the left, the pain increased, neck with do shoulder blade position and all have obvious tenderness sense, X sheet shows the slight lateral bending of cervical flexure, be diagnosed as: nerve root cervical vertebra sickness, because patient does not want to spend the too many money of sons and daughters, doctor just suggestion uses embodiment 2 gained plaster.
Use the embodiment of the present invention 2 gained plaster, once a day, each subsides worn 12 hours, and neck and scapular region are each pastes one, within 10 days, is a course for the treatment of. Use 5 days, position is worn in subsides the sensation of heating, feels well. Use 20 days, pain alleviates. Use 30 days, in the situation that noting posture and rest, substantially can avoid the generation of cervical pain symptom, omoplate place pain disappears completely, and neck can swing comparatively normally, and defecation is normal, and generation had no side effect between the operating period.
Embodiment 3Treat a plaster for nerve root cervical vertebra sickness, take off the primary raw material of stating weight proportion and be prepared from (getting 20g for every part): 10 parts of the roots of kudzu vine, 7 parts of lycopodium calvatums, 11 parts of rhizoma dioscoreae nipponicaes, 6 parts of notopterygium roots, 6 parts of rhizoma curcumae longae concisas, 8 parts of zaocys dhumnades, 10 parts of pyrolas, 7 parts of yncaria stems with hooks, 2 parts of asiatic toddalia root-barks, 4 parts of pangolins.
The preparation method of the plaster of above-mentioned treatment nerve root cervical vertebra sickness, step is:
1. the root of kudzu vine, lycopodium calvatum, rhizoma dioscoreae nipponicae, notopterygium root, rhizoma curcumae longae concisa, zaocys dhumnade are placed in non iron container, add ethanol, the consumption of ethanol is 2 times of bulk drug gross weight, and sealing is placed in shady and cool ventilation place and leaves standstill 3 days, and filtration, obtains filtrate and filter residue is for subsequent use;
2. step 1. in gained filter residue add water, the consumption of water is 4 times of filter residue consumption, and adds asiatic toddalia root-bark, pyrola, yncaria stem with hooks, pangolin, intense fire is fried open, the fire of larding speech with literary allusions is decocted slowly, decocts to 35 minutes, filters to get filtrate;
3. by step 1. in gained filtrate and step 2. in gained filtrate mixes, standing 7 hours, filtration, filtrate is purified again by the way of distillation, obtains distillate for subsequent use;
4. in pot, add vegetable oil and rosin heating, do not stop to stir, to be mixedly add albolene to continue to add thermal agitation after evenly, excipient to be mixed is old tender when suitable, closes fire and is cooled to 65 DEG C, add 3. middle gained distillate of step, after stirring, slow fire is endured slowly, after removal moisture, is cooled to 65 DEG C, get 3g and spread upon in adhesive plaster or other matrix, make plaster.
Typical case threeOpen XX, man, 60 years old, people from Qingzhou, Weifang City, peasant. Nerve root cervical vertebra sickness history 1 year, cervicodynia is uncomfortable in chest, and with the symptom of eye-blurred, and right arm sensation grips unablely recently, and health has constrained sense, and all senses that couches night are uncomfortable, and cannot falling asleep, it is One's spirits are drooping to cause. Check and find patient's instability of gait, hands grasping power is all not high, and right arm situation is even more serious, and compression of spinal cord is comparatively obvious, seeks medical advice everywhere, all to no effect, sees unintentionally plaster of the present invention on newspaper, has the attitude of trying in arms and has bought 2 courses for the treatment of.
Use the embodiment of the present invention 3 gained plaster, once a day, each subsides worn 12 hours, and neck and right arm scapular region are each pastes one, within 10 days, is a course for the treatment of. Use 10 days, nighttime sleep has clear improvement, and can fall asleep. Use 20 days, both hands have obvious strength high, and mental attitude is taken on a new look to some extent, and pain symptom alleviates. Use 30 days, pain obviously alleviates, and mental restoration is good, and eyesight is also recovered to some extent. Use 50 days, other malaise symptoms disappear substantially, the recovery from illness of patient's self-induction.
1、Embodiment 4Treat a plaster for nerve root cervical vertebra sickness, take off the primary raw material of stating weight proportion and be prepared from (getting 25g for every part): 12 parts of the roots of kudzu vine, 8 parts of lycopodium calvatums, 13 parts of rhizoma dioscoreae nipponicaes, 8 parts of notopterygium roots, 9 parts of rhizoma curcumae longae concisas, 10 parts of zaocys dhumnades, 12 parts of pyrolas, 8 parts of yncaria stems with hooks, 4 parts of asiatic toddalia root-barks, 6 parts of pangolins.
The preparation method of the plaster of above-mentioned treatment nerve root cervical vertebra sickness, step is:
1. the root of kudzu vine, lycopodium calvatum, rhizoma dioscoreae nipponicae, notopterygium root, rhizoma curcumae longae concisa, zaocys dhumnade are placed in non iron container, add ethanol, the consumption of ethanol is 2 times of bulk drug gross weight, and sealing is placed in shady and cool ventilation place and leaves standstill 8 days, and filtration, obtains filtrate and filter residue is for subsequent use;
2. step 1. in gained filter residue add water, the consumption of water is 4 times of filter residue consumption, and adds asiatic toddalia root-bark, pyrola, yncaria stem with hooks, pangolin, intense fire is fried open, the fire of larding speech with literary allusions is decocted slowly, decocts to 45 minutes, filters to get filtrate;
3. by step 1. in gained filtrate and step 2. in gained filtrate mixes, standing 10 hours, filtration, filtrate is purified again by the way of distillation, obtains distillate for subsequent use;
4. in pot, add vegetable oil and rosin heating, do not stop to stir, to be mixedly add albolene to continue to add thermal agitation after evenly, excipient to be mixed is old tender when suitable, closes fire and is cooled to 75 DEG C, add 3. middle gained distillate of step, after stirring, slow fire is endured slowly, after removal moisture, is cooled to 65 DEG C, get 8g and spread upon in adhesive plaster or other matrix, make plaster.
Embodiment 5Treat a plaster for nerve root cervical vertebra sickness, take off the primary raw material of stating weight proportion and be prepared from (getting 30g for every part): 11 parts of the roots of kudzu vine, 7.5 parts of lycopodium calvatums, 12 parts of rhizoma dioscoreae nipponicaes, 7 parts of notopterygium roots, 8 parts of rhizoma curcumae longae concisas, 9 parts of zaocys dhumnades, 11 parts of pyrolas, 7.5 parts of yncaria stems with hooks, 3 parts of asiatic toddalia root-barks, 5 parts of pangolins.
The preparation method of the plaster of above-mentioned treatment nerve root cervical vertebra sickness, step is:
1. the root of kudzu vine, lycopodium calvatum, rhizoma dioscoreae nipponicae, notopterygium root, rhizoma curcumae longae concisa, zaocys dhumnade are placed in non iron container, add ethanol, the consumption of ethanol is 2 times of bulk drug gross weight, and sealing is placed in shady and cool ventilation place and leaves standstill 5 days, and filtration, obtains filtrate and filter residue is for subsequent use;
2. step 1. in gained filter residue add water, the consumption of water is 4 times of filter residue consumption, and adds asiatic toddalia root-bark, pyrola, yncaria stem with hooks, pangolin, intense fire is fried open, the fire of larding speech with literary allusions is decocted slowly, decocts to 40 minutes, filters to get filtrate;
3. by step 1. in gained filtrate and step 2. in gained filtrate mixes, standing 9 hours, filtration, filtrate is purified again by the way of distillation, obtains distillate for subsequent use;
4. in pot, add vegetable oil and rosin heating, do not stop to stir, to be mixedly add albolene to continue to add thermal agitation after evenly, excipient to be mixed is old tender when suitable, closes fire and is cooled to 70 DEG C, add 3. middle gained distillate of step, after stirring, slow fire is endured slowly, after removal moisture, is cooled to 65 DEG C, get 5g and spread upon in adhesive plaster or other matrix, make plaster.
Experimental exampleIn order to verify the curative effect of the present invention to nerve root cervical vertebra sickness, choose two or more person 200 people of nerve root cervical vertebra sickness symptom, the mean age is 40 years old, be divided into two groups according to the state of an illness, experimental group and control group, every group of 100 people, basically identical to ensure two groups of situations. Experimental group is used embodiment 5 gained plaster, once a day, each subsides worn 12 hours, it within 10 days, is a course for the treatment of, control group uses the Chinese medicine of other oral medication nerve root cervical vertebra sicknesses, observes 30 days time limits, before experiment, first patient's symptom is comprehensively checked in 1 day, when experiment, regularly check inquiry patient body situation and impression, and make a record.
1, the curative effect of two groups of medicines is carried out to record, result is as following table 1. (criterion, effectively: the malaise symptoms being caused by nerve root cervical vertebra sickness has clear improvement; Invalid: the malaise symptoms being caused by nerve root cervical vertebra sickness is unchanged. )
Table 1:
Analyze:As can be seen from Table 1, the present invention is 99% to the efficient of nerve root cervical vertebra sickness, exceeds control group 19%, and effect is remarkable.
2, two groups of patient's applied mentals are changed and carry out record, result is as following table 2.
Table 2:
| Group | Number | Can consciously adhere to the number for the treatment of | There is no positive effect in a short time and produce psychological burden number | The number that long-term use can also be accepted |
| Experimental group | 100 | 100 | 1 | 99 |
| Control group | 100 | 80 | 30 | 85 |
Analyze:As can be seen from Table 2, medicament mode of the present invention more easily approved by patient, and major part represents per capita, Long-term taking medicine easily causes psychological pressure, and can obviously affect appetite, external used medicine is favored by more people on therapeutic modality, is also more easy to accept and adhere to long-term treatment. Through can find out the analysis of many groups experimental data, plaster of the present invention is obvious for nerve root cervical vertebra sickness curative effect, and total effective rate is up to 99%, and without any side effects, can reach comparatively rapidly the effect of pain-alleviating and network vessel-freeing. On therapeutic modality, the present invention is also easier to the recognition and acceptance by patient, can lay a good foundation for later treatment. Chinese medicine composition of the present invention has been obtained significant effect in treatment nerve root cervical vertebra sickness, and curative effect is stable, has no side effect, and is suitable for long-term taking.
Claims (1)
1. a plaster for the treatment of nerve root cervical vertebra sickness, is characterized in that, the bulk drug of getting following portions by weight is prepared from: 11 parts of the roots of kudzu vine, 7.5 parts of lycopodium calvatums, 12 parts of rhizoma dioscoreae nipponicaes, 7 parts of notopterygium roots, 8 parts of rhizoma curcumae longae concisas, 9 parts of zaocys dhumnades, 11 parts of pyrolas, 7.5 parts of yncaria stems with hooks, 3 parts of asiatic toddalia root-barks, 5 parts of pangolins.
Priority Applications (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201610095639.1A CN105688040A (en) | 2014-04-28 | 2014-04-28 | Plaster for treating cervical spondylotic radiculopathy |
| CN201410173689.8A CN103948863B (en) | 2014-04-28 | 2014-04-28 | A kind of plaster for the treatment of nerve root cervical vertebra sickness and preparation method thereof |
| CN201610095637.2A CN105561208A (en) | 2014-04-28 | 2014-04-28 | Traditional Chinese medicine unguent for treating cervical spondylotic radiculopathy |
| CN201610095638.7A CN105597021A (en) | 2014-04-28 | 2014-04-28 | Plaster for treating nerve-root type cervical spondylopathy |
| CN201610095636.8A CN105561207A (en) | 2014-04-28 | 2014-04-28 | Medicine composition for treating nerve-root type cervical spondylosis |
| CN201610095640.4A CN105688041A (en) | 2014-04-28 | 2014-04-28 | Preparation method of plaster for treating cervical spondylotic radiculopathy |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410173689.8A CN103948863B (en) | 2014-04-28 | 2014-04-28 | A kind of plaster for the treatment of nerve root cervical vertebra sickness and preparation method thereof |
Related Child Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610095639.1A Division CN105688040A (en) | 2014-04-28 | 2014-04-28 | Plaster for treating cervical spondylotic radiculopathy |
| CN201610095638.7A Division CN105597021A (en) | 2014-04-28 | 2014-04-28 | Plaster for treating nerve-root type cervical spondylopathy |
| CN201610095640.4A Division CN105688041A (en) | 2014-04-28 | 2014-04-28 | Preparation method of plaster for treating cervical spondylotic radiculopathy |
| CN201610095636.8A Division CN105561207A (en) | 2014-04-28 | 2014-04-28 | Medicine composition for treating nerve-root type cervical spondylosis |
| CN201610095637.2A Division CN105561208A (en) | 2014-04-28 | 2014-04-28 | Traditional Chinese medicine unguent for treating cervical spondylotic radiculopathy |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN103948863A CN103948863A (en) | 2014-07-30 |
| CN103948863B true CN103948863B (en) | 2016-05-11 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610095637.2A Withdrawn CN105561208A (en) | 2014-04-28 | 2014-04-28 | Traditional Chinese medicine unguent for treating cervical spondylotic radiculopathy |
| CN201610095636.8A Withdrawn CN105561207A (en) | 2014-04-28 | 2014-04-28 | Medicine composition for treating nerve-root type cervical spondylosis |
| CN201610095639.1A Withdrawn CN105688040A (en) | 2014-04-28 | 2014-04-28 | Plaster for treating cervical spondylotic radiculopathy |
| CN201610095638.7A Withdrawn CN105597021A (en) | 2014-04-28 | 2014-04-28 | Plaster for treating nerve-root type cervical spondylopathy |
| CN201610095640.4A Pending CN105688041A (en) | 2014-04-28 | 2014-04-28 | Preparation method of plaster for treating cervical spondylotic radiculopathy |
| CN201410173689.8A Active CN103948863B (en) | 2014-04-28 | 2014-04-28 | A kind of plaster for the treatment of nerve root cervical vertebra sickness and preparation method thereof |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201610095637.2A Withdrawn CN105561208A (en) | 2014-04-28 | 2014-04-28 | Traditional Chinese medicine unguent for treating cervical spondylotic radiculopathy |
| CN201610095636.8A Withdrawn CN105561207A (en) | 2014-04-28 | 2014-04-28 | Medicine composition for treating nerve-root type cervical spondylosis |
| CN201610095639.1A Withdrawn CN105688040A (en) | 2014-04-28 | 2014-04-28 | Plaster for treating cervical spondylotic radiculopathy |
| CN201610095638.7A Withdrawn CN105597021A (en) | 2014-04-28 | 2014-04-28 | Plaster for treating nerve-root type cervical spondylopathy |
| CN201610095640.4A Pending CN105688041A (en) | 2014-04-28 | 2014-04-28 | Preparation method of plaster for treating cervical spondylotic radiculopathy |
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Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN104306536A (en) * | 2014-09-27 | 2015-01-28 | 王纬 | A plaster for treating nerve-root type cervical spondylosis and a preparing method thereof |
| CN104491072A (en) * | 2015-01-04 | 2015-04-08 | 霍山县中医院 | Traditional Chinese medicine for treating nerve-root type cervical spondylosis |
| CN104706793A (en) * | 2015-02-25 | 2015-06-17 | 黄桂荣 | Traditional Chinese medicine anaesthesia pain relieving tincture for treating nerve-root type cervical spondylosis |
Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1090771A (en) * | 1993-02-12 | 1994-08-17 | 武秋华 | Medicine " Yuntongling " for treating dizziness and headache |
| CN1416837A (en) * | 2001-11-08 | 2003-05-14 | 纪玉田 | Bone Bi-syndrome treating pill |
| CN101129973A (en) * | 2006-08-25 | 2008-02-27 | 范广友 | Traditional Chinese medicine for treating cervical vertebra disease |
| CN103070994A (en) * | 2013-02-17 | 2013-05-01 | 马云波 | Plaster for treating cervical and lumbar spondylosis |
| CN103083609A (en) * | 2011-10-28 | 2013-05-08 | 刘亚芝 | Traditional Chinese medicine for treating cervical spondylosis, lumbar intervertebral disc herniation and ankylosing spondylitis |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101721660A (en) * | 2008-10-22 | 2010-06-09 | 张彬 | Plaster for curing cervical spondylosis |
| CN101926969B (en) * | 2010-06-03 | 2014-06-25 | 陕西中医学院 | Traditional Chinese medicine composition for treatment of cervical spondylopathy and preparation method thereof |
-
2014
- 2014-04-28 CN CN201610095637.2A patent/CN105561208A/en not_active Withdrawn
- 2014-04-28 CN CN201610095636.8A patent/CN105561207A/en not_active Withdrawn
- 2014-04-28 CN CN201610095639.1A patent/CN105688040A/en not_active Withdrawn
- 2014-04-28 CN CN201610095638.7A patent/CN105597021A/en not_active Withdrawn
- 2014-04-28 CN CN201610095640.4A patent/CN105688041A/en active Pending
- 2014-04-28 CN CN201410173689.8A patent/CN103948863B/en active Active
Patent Citations (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1090771A (en) * | 1993-02-12 | 1994-08-17 | 武秋华 | Medicine " Yuntongling " for treating dizziness and headache |
| CN1416837A (en) * | 2001-11-08 | 2003-05-14 | 纪玉田 | Bone Bi-syndrome treating pill |
| CN101129973A (en) * | 2006-08-25 | 2008-02-27 | 范广友 | Traditional Chinese medicine for treating cervical vertebra disease |
| CN103083609A (en) * | 2011-10-28 | 2013-05-08 | 刘亚芝 | Traditional Chinese medicine for treating cervical spondylosis, lumbar intervertebral disc herniation and ankylosing spondylitis |
| CN103070994A (en) * | 2013-02-17 | 2013-05-01 | 马云波 | Plaster for treating cervical and lumbar spondylosis |
Also Published As
| Publication number | Publication date |
|---|---|
| CN103948863A (en) | 2014-07-30 |
| CN105597021A (en) | 2016-05-25 |
| CN105561208A (en) | 2016-05-11 |
| CN105688040A (en) | 2016-06-22 |
| CN105688041A (en) | 2016-06-22 |
| CN105561207A (en) | 2016-05-11 |
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Effective date of registration: 20160413 Address after: 342200 Wenfeng Industrial Park, Xunwu, Jiangxi, Ganzhou Applicant after: JIANGXI DIKANG PHARMACEUTICAL Co.,Ltd. Address before: 250000 Ji'nan, Licheng District, Sun Village, white Valley heap No. two District No. 103 Applicant before: Guo Ruying |
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Denomination of invention: A plaster for treating cervical spondylosis of nerve root type and its preparation method Effective date of registration: 20221219 Granted publication date: 20160511 Pledgee: Agricultural Bank of China Limited Xunwu County Sub branch Pledgor: JIANGXI DIKANG PHARMACEUTICAL Co.,Ltd. Registration number: Y2022980028160 |
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