CN112717081B - Blood-activating face-beautifying cream formula and application thereof - Google Patents

Blood-activating face-beautifying cream formula and application thereof Download PDF

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Publication number
CN112717081B
CN112717081B CN202110200952.8A CN202110200952A CN112717081B CN 112717081 B CN112717081 B CN 112717081B CN 202110200952 A CN202110200952 A CN 202110200952A CN 112717081 B CN112717081 B CN 112717081B
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parts
portions
raw
white
blood
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CN112717081A (en
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张晓天
唐嘉仪
缪佳
蒋梦琳
余承鸿
韦硕硕
王莹
朱蕴华
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Shuguang Hospital Affiliated to Shanghai University of TCM
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Shuguang Hospital Affiliated to Shanghai University of TCM
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Abstract

The invention relates to a blood circulation promoting and skin beautifying paste formula and application thereof, wherein the blood circulation promoting and skin beautifying paste formula is prepared from the following raw material medicines in parts by weight: raw astragalus membranaceus, radix pseudostellariae, raw bighead atractylodes rhizome, fried white paeony root, white poria, dittany bark, Japanese ampelopsis root, cynanchum atratum bunge, angelica dahurica, white mulberry root-bark, vinegar-processed radix bupleuri, angelica sinensis, fried red paeony root, raw rehmannia root, fried ligusticum wallichii, safflower, peach kernel paste, rose, caulis spatholobi, raw coix seed, cooked coix seed, dioscorea opposita thumb, lotus seed pulp, Chinese date, raw liquorice, loofah sponge, beautiful sweetgum fruit, donkey-hide gelatin, maltose, white honey and yellow wine. The blood-activating face-beautifying cream formula has obvious curative effect on conditioning qi-depression blood-stasis constitution of women with rather severe constitution, is convenient for diagnosis, treatment and use, and is suitable for being prepared into a finished cream formula to be popularized clinically.

Description

Blood-activating face-beautifying cream formula and application thereof
Technical Field
The invention relates to the field of traditional Chinese medicines, in particular to a blood-activating and face-beautifying paste formula and application thereof.
Background
The traditional Chinese medicine health-preserving paste formula is a semi-fluid preparation prepared by repeatedly decocting traditional Chinese medicine decoction pieces according to the principle of traditional Chinese medicine, removing residues, taking juice, evaporating and concentrating, and adding sugar, honey or donkey-hide gelatin and the like, has good effects on weak and susceptible people, sub-health states, chronic diseases, special crowds such as children, women, old people and the like, and is increasingly widely applied in modern clinic.
In long-term clinical practice, the self-prepared paste formula for promoting blood circulation and beautifying is used for conditioning the constitution of qi depression and blood stasis of women, and a good curative effect is obtained. The self-prepared blood-activating face-beautifying paste comprises the following components: the basic formula is as follows: 90g of vinegar-processed radix bupleuri, 90g of Guangdong radix curcumae, 150g of fried red peony root, 90g of peach kernel paste, 60g of grass safflower, 150g of fried rhizoma ligustici wallichii, 150g of whole angelica, 150g of fried white peony root, 60g of white poria, 150g of Japanese ampelopsis root, 100g of fried bighead atractylodes rhizome, 150g of cynanchum atratum, 100g of dittany bark, 100g of mulberry bark, 90g of prepared rehmannia root, 60g of Chinese rose flower, 60g of rose, 200g of uncooked cooked coix seed, 90g of raw licorice, 90g of Guangdong radix curcumae, 100g of red date, 100g of walnut meat, 100g of lotus seed meat, 100g of longan pulp and 100g of black sesame. The medicines are decocted in a thick mode, dregs are removed, the thick juice is taken to be added with 300g of donkey-hide gelatin, 500g of white honey (400 g of xylitol for diabetics) and 500g of yellow wine, and the mixture is melted to obtain paste. On the basis of the basic formula, white ginseng, radix codonopsis pilosulae and raw radix astragali preparata are added for patients with qi deficiency; colla Cornus Cervi is selected for patients with yang deficiency; scutellariae radix and Coptidis rhizoma for patients with heat syndrome; radix Saposhnikoviae can be added for patients with common cold; radix Panacis Quinquefolii, radix Adenophorae, radix Glehniae, radix Ophiopogonis, and herba Dendrobii for patients with insufficient body fluid; scolopendra and Scorpio can be added for patients with chronic diseases and requiring wind dispelling and collaterals dredging; semen Cannabis and fructus Aurantii Immaturus may be added for patients with constipation; semen Platycladi, semen Ziziphi Spinosae, flos Hibisci Sabdariffae, cortex Albizziae, caulis Polygoni Multiflori, Magnetitum preparata, and dens Draconis can be added for insomnia; for patients with waist soreness, Eucommiae cortex, radix Cyathulae, herba Taxilli, and rhizoma Cibotii can be added. The applicant continuously adjusts the composition of the prescription in the later clinical work to obtain the blood-activating and face-beautifying cream formula which has more obvious effect of conditioning the constitution of qi depression and blood stasis of women without differentiation of symptoms or additions.
Disclosure of Invention
The invention aims to provide a formula of blood-activating and face-beautifying cream aiming at the defects in the prior art.
The invention further aims to provide a preparation method of the blood-activating face-beautifying cream formula.
The invention also aims to provide application of the blood-activating and face-beautifying cream formula.
In order to achieve the first purpose, the invention adopts the technical scheme that:
the blood circulation promoting and face beautifying paste formula is prepared from the following raw material medicines in parts by weight: 180 portions of raw astragalus root, 180 portions of radix pseudostellariae, 80 to 120 portions of raw rhizoma atractylodis macrocephalae, 180 portions of fried white paeony root, 180 portions of white poria, 80 to 100 portions of cortex dictamni, 80 to 100 portions of ampelopsis japonica, 80 to 100 portions of cynanchum atratum, 80 to 100 portions of angelica dahurica, 80 to 100 portions of mulberry bark, 80 to 100 portions of vinegar radix bupleuri, 180 portions of angelica sinensis, 80 to 120 portions of fried red paeony root, 80 to 120 portions of radix rehmanniae recen, 180 portions of fried rhizoma ligustici wallichii, 80 to 100 portions of safflower carthamus, 80 to 100 portions of peach kernel paste, 50 to 70 portions of rose, 180 portions of caulis spatholobi, 180 portions of raw semen coicis, 180 portions of cooked semen coicis, 180 portions of rhizoma dioscoreae, 80 to 120 portions of lotus seed, 80 to 100 portions of Chinese date, 80 to 100 portions of raw licorice, 50 to 70 portions of retinervus luffae fructus, and the like, 80-120 parts of beautiful sweetgum fruit, 200-300 parts of Dong donkey-hide gelatin, 200-300 parts of maltose, 200-300 parts of white honey and 200-300 parts of yellow wine.
Preferably, the traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 160 portions of 140 portions of raw astragalus root, 160 portions of 140 portions of radix pseudostellariae, 90 to 110 portions of raw rhizoma atractylodis macrocephalae, 160 portions of fried white paeony root, 160 portions of white poria, 80 to 100 portions of cortex dictamni, 80 to 100 portions of ampelopsis japonica, 80 to 100 portions of cynanchum atratum, 80 to 100 portions of angelica dahurica, 80 to 100 portions of mulberry bark, 80 to 100 portions of vinegar radix bupleuri, 160 portions of angelica root, 90 to 110 portions of fried red paeony root, 90 to 110 portions of radix rehmanniae recen, 160 portions of fried rhizoma ligustici wallichii 140, 80 to 100 portions of safflower carthamus, 80 to 100 portions of peach kernel paste, 50 to 70 portions of rose, 160 portions of caulis spatholobi 140, 160 portions of raw coix seed, 160 portions of cooked coix seed, 140 portions of dioscorea opposita japonica, 90 to 110 portions of lotus seed meat, 80 to 100 portions of Chinese date, 80 to 100 portions of raw liquorice, 50 to 70 portions of luffa vegetable sponge, 50 to 70 portions of white gourd fruit, 90-110 parts of beautiful sweetgum fruit, 280 parts of eastern donkey-hide gelatin, 280 parts of cerealose, 280 parts of white honey and 280 parts of yellow wine.
More preferably, the traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 150 parts of raw astragalus membranaceus, 150 parts of radix pseudostellariae, 100 parts of raw white atractylodes rhizome, 150 parts of fried white peony root, 150 parts of white poria, 90 parts of cortex dictamni, 90 parts of radix ampelopsis, 90 parts of cynanchum atratum bunge, 90 parts of radix angelicae, 90 parts of white mulberry root-bark, 90 parts of vinegar radix bupleuri, 150 parts of angelica sinensis, 100 parts of fried red peony root, 100 parts of radix rehmanniae recen, 150 parts of fried ligusticum wallichii, 90 parts of safflower carthamus, 90 parts of peach kernel paste, 60 parts of rose, 150 parts of caulis spatholobi, 150 parts of raw coix seed, 150 parts of cooked coix seed, 150 parts of Chinese yam, 100 parts of lotus seed, 90 parts of Chinese date, 90 parts of raw liquorice, 60 parts of loofah sponge, 100 parts of fructus liquidambaris, 250 parts of donkey-hide gelatin, 250 parts of maltose, 250 parts of white honey and 250 parts of yellow rice wine.
Preferably, the preparation method is as follows: decocting raw materials except colla Corii Asini, maltose, Mel and yellow wine, removing residue, adding concentrated juice into colla Corii Asini, maltose, Mel and yellow wine, melting, and collecting paste.
Preferably, it further comprises a pharmaceutically acceptable carrier.
In order to achieve the second object, the invention adopts the technical scheme that:
the preparation method of the blood-activating face-beautifying paste formula comprises the steps of taking raw materials except the donkey-hide gelatin, the maltose, the white honey and the yellow wine, carrying out thick decoction, removing residues, taking thick juice, adding the donkey-hide gelatin, the maltose, the white honey and the yellow wine, melting and collecting paste.
In order to achieve the third object, the invention adopts the technical scheme that:
the application of the blood-activating face-beautifying cream formula in preparing foods, health-care products or medicines for conditioning female constitution of qi depression and blood stasis.
Herein, the raw astragalus root, namely the dried astragalus root, is sliced. Radix Pseudostellariae is dry root tuber of Pseudostellaria heterophylla of Caryophyllaceae. The rhizoma Atractylodis Macrocephalae is dried rhizome of Atractylodes macrocephala Koidz of Compositae. The parched radix Paeoniae alba is prepared by parching radix Paeoniae alba slice in a pan to slight yellow. The white poria is the white part of the medicinal material poria mass cut with red poria. Cortex Dictamni Radicis is root bark of Dictamnus dasycarpus of Rutaceae family. The radix Ampelopsis refers to dry root tuber of Ampelopsis japonica Makino of Vitaceae. The radix Cynanchi Atrati is root and rhizome of Cynanchum atratum (L.) Hance of Asclepiadaceae. Radix Angelicae Dahuricae is dried root of Angelica dahurica or Angelica dahurica of Umbelliferae. Cortex Mori is dry root bark of Morus alba L.of Moraceae of dicotyledon after removing cortex. Vinegar bupleuri radix is prepared by air drying bupleuri radix, cutting into segments, spraying rice vinegar, stewing thoroughly, and parching with slow fire slightly. Dang Gui is the trunk part of Dang Gui root. The parched radix Paeoniae Rubra is the parched product of radix Paeoniae Rubra. Radix rehmanniae is root tuber of rehmannia glutinosa Libosch of Scrophulariaceae. The stir-frying method of the stir-fried ligusticum wallichii comprises the following steps: taking the ligusticum wallichii slices, putting the ligusticum wallichii slices into a pot, and frying the ligusticum wallichii slices with slow fire until the surfaces of the ligusticum wallichii slices turn yellow. The Carthami flos is dried flower of Carthamus Tinctorius of Compositae. Mashed semen Persicae is mashed semen Persicae. The flos Rosae Rugosae is flower of Rosa rugosa Thunb of Rosaceae. Caulis Spatholobi is dry rattan of Spatholobus Suffruticosa of Leguminosae. The raw Coicis semen is dried mature seed of Gramineae plant Coicis semen, sun-dried in autumn when fruit is mature, and directly used after removing shell, tawny seed coat and impurities. The cooked Coicis semen is obtained by parching Coicis semen with wheat bran until its surface turns yellowish. The dioscorea opposita is a medicinal dioscorea opposita produced in the south of Henan. Lotus seed meat is produced in Hunan quan. Fructus Jujubae is mature fruit of Zizyphi fructus of Rhamnaceae. Raw licorice refers to the dry root and rhizome of the medicinal plant licorice. Retinervus Luffae fructus is the vascular bundle of dried mature fruit of Luffae fructus of Cucurbitaceae. Fructus Lipuidambaris is dry mature infructescence of Liquidambar formosana Hance of Hamamelidaceae, harvesting after fruit ripening in winter, removing impurities, and drying. The Dong E jiao is a glue block prepared by removing hair from donkey skin of Equidae donkey and decocting.
The invention has the advantages that:
1. according to the blood-activating and face-beautifying paste formula, raw radix astragali and radix pseudostellariae are used for tonifying qi in the formula, the raw radix astragali is good for tonifying qi of the whole body and has the functions of invigorating yang and consolidating exterior, and the radix pseudostellariae is capable of tonifying qi and strengthening spleen, promoting the production of body fluid and moistening lung; the white atractylodes rhizome, rhizoma atractylodis macrocephalae, radix paeoniae alba, white poria, cortex dictamni, radix ampelopsis, radix cynanchi atrati, radix angelicae dahuricae and cortex mori radicis are used for whitening and removing spots when used as raw materials; the raw white atractylodes rhizome is used for whitening, and is derived from clearing damp and tonifying spleen to enable face damp turbidity to descend; the stir-fried white paeony root plays a role in nourishing yin to ensure that the face is moist and glossy; the angelica dahurica is used for treating the pulse Yang Ming and the qi and blood upward-floating face; the white poria cocos is comprehensively conditioned for tonifying qi and cultivating spirit; the cortex dictamni has the effects of clearing heat, eliminating dampness, detoxifying, removing speckles and beautifying; ampelopsis root, radix Ampelopsis, bitter in flavor and diarrhea, can clear away damp-heat and unblock stagnation, so the "Yi Xue Lun" records "treatment of pemphigus on the face; bai Wei enters yin system to clear heat and cool blood, and remove heat pathogen from nutrient and blood. Vinegar radix bupleuri and rose flower have the effects of soothing liver-qi stagnation. The angelica, the dried rehmannia root, the fried red peony root, the fried hemlock parsley, the safflower, the mashed peach kernel and the suberect spatholobus stem have the functions of promoting blood circulation and nourishing blood, and the angelica is mainly used for enriching blood; the dried rehmannia root is sweet in taste and bitter and cold in flavor, and is better at clearing heat, nourishing blood, nourishing yin and promoting the production of body fluid; the fried red peony root has the effects of nourishing blood and softening liver, and can invigorate qi and blood and make the face ruddy when being fried; stir-baked Chuan Xiong can not only activate blood and resolve stasis, but also move qi, and is the "qi in blood" herb; the two herbs are mutually reinforced to be used, namely, ascending and descending, dispersing and collecting, the efficacy of promoting blood circulation and removing blood stasis is doubled, and the effect of promoting blood circulation and promoting tissue regeneration is achieved; caulis Spatholobi is effective in promoting blood circulation and replenishing blood. Although the raw and cooked coix seeds are classified as diuresis inducing and diuresis inducing drugs, the coix seeds are usually used in the paste formula to tonify the spleen and regulate qi, and the Chinese yam is used for tonifying the spleen, and the lotus seed meat is used for tonifying the spleen. The beautiful sweetgum fruit is matched with the cucurbituril, dispels wind, dredges collaterals, reduces phlegm and stagnation; licorice root, radix Glycyrrhizae and Zizyphi fructus, which are effective in invigorating qi, regulating middle warmer, and strengthening healthy qi. The maltose is capable of tonifying middle-jiao and Qi, strengthening spleen and stomach, the donkey-hide gelatin is capable of replenishing blood and nourishing Yin, the white honey is capable of tonifying middle-jiao and moistening dryness, the yellow wine is capable of activating blood and dredging collaterals, medicine is capable of guiding meridian, taste is improved, and the taste is delicious, and the medicines are harmonized.
2. The blood-activating face-nourishing paste formula can obviously improve the constitution of qi depression and blood stasis of women with a rather serious constitution, does not need dialectical treatment, is more convenient to use, and is suitable for popularization and application in preparing a patent paste formula.
Detailed Description
The following provides a detailed description of specific embodiments of the present invention.
Example 1 preparation of a formula of the blood-activating and beauty-maintaining cream of the invention
150g of raw astragalus membranaceus, 150g of radix pseudostellariae, 100g of raw bighead atractylodes rhizome, 150g of fried white peony root, 150g of white poria, 90g of dittany bark, 90g of Japanese ampelopsis root, 90g of cynanchum atratum, 90g of angelica dahurica, 90g of mulberry bark, 90g of vinegar radix bupleuri, 150g of angelica sinensis, 100g of fried red peony root, 100g of radix rehmanniae recen, 150g of fried ligusticum wallichii, 90g of safflower carthamus, 90g of peach kernel paste, 60g of rose, 150g of caulis spatholobi, 150g of raw coix seed, 150g of cooked coix seed, 150g of Chinese yam, 100g of lotus seed meat, 90g of Chinese date, 90g of raw licorice, 60g of loofah sponge and 100g of beautiful sweetgum fruit. Decocting the above materials, removing residues, adding 250g of colla Corii Asini, 250g of maltose, 250g of Mel (200 g of xylitol for diabetic patients), and 250g of yellow wine, melting, and collecting paste.
Example 2 preparation of the blood-activating and beauty-maintaining cream formulation of the present invention (II)
120g of raw astragalus membranaceus, 180g of radix pseudostellariae, 80g of raw bighead atractylodes rhizome, 180g of fried white peony root, 120g of white poria, 100g of dittany bark, 80g of Japanese ampelopsis root, 100g of cynanchum atratum, 80g of angelica dahurica, 100g of mulberry bark, 80g of vinegar radix bupleuri, 180g of angelica sinensis, 80g of fried red peony root, 120g of radix rehmanniae recen, 120g of fried ligusticum wallichii, 100g of safflower carthamus, 80g of peach kernel paste, 70g of rose, 120g of caulis spatholobi, 180g of raw coix seed, 120g of cooked coix seed, 180g of Chinese yam, 80g of lotus seed meat, 100g of Chinese date, 80g of raw licorice, 70g of loofah sponge and 80g of beautiful sweetgum fruit. Decocting the above materials, removing residues, adding concentrated juice into colla Corii Asini 300g, maltose 200g, Mel 300g (for diabetic patients, xylitol 240g), and yellow wine 200g, melting, and collecting paste.
Example 3 preparation of a formula of blood-activating and skin-caring cream according to the invention
120g of raw astragalus membranaceus, 120g of radix pseudostellariae, 80g of raw bighead atractylodes rhizome, 180g of fried white peony root, 180g of white poria, 100g of dittany bark, 80g of Japanese ampelopsis root, 80g of cynanchum atratum, 80g of angelica dahurica, 100g of white mulberry root-bark, 100g of vinegar radix bupleuri, 180g of angelica, 80g of fried red peony root, 80g of radix rehmanniae recen, 120g of fried ligusticum wallichii, 100g of safflower carthamus, 100g of peach kernel paste, 70g of rose, 120g of caulis spatholobi, 120g of raw coix seed, 120g of cooked coix seed, 180g of Chinese yam, 120g of lotus seed meat, 100g of Chinese date, 80g of raw licorice, 50g of loofah sponge and 80g of beautiful sweetgum fruit. Decocting the above materials, removing residues, adding concentrated juice into DONGcolla Corii Asini 300g, maltose 300g, Mel 200g (xylitol 160g for diabetic patients), and yellow wine 200g, melting, and collecting paste.
Example 4 preparation of a formula of blood-activating and skin-caring cream according to the Invention (IV)
180g of raw astragalus membranaceus, 120g of radix pseudostellariae, 120g of raw bighead atractylodes rhizome, 120g of fried white peony root, 180g of white poria, 80g of dittany bark, 100g of radix ampelopsis, 80g of cynanchum atratum, 100g of radix angelicae, 80g of white mulberry root-bark, 100g of vinegar radix bupleuri, 120g of angelica sinensis, 120g of fried red peony root, 80g of radix rehmanniae recen, 180g of fried ligusticum wallichii, 80g of safflower carthamus, 100g of peach kernel paste, 50g of rose, 180g of caulis spatholobi, 120g of raw coix seed, 180g of cooked coix seed, 120g of Chinese yam, 120g of lotus seed meat, 80g of Chinese date, 100g of raw licorice, 50g of loofah sponge and 120g of beautiful sweetgum fruit. Decocting the above materials, removing residues, adding 200g colla Corii Asini, 300g maltose, 200g Mel (for diabetic patients, xylitol 160g), and 300g yellow wine, melting, and collecting paste.
Example 5 preparation of a formula of the blood-activating and beauty-maintaining cream of the invention (V)
180g of raw astragalus membranaceus, 180g of heterophylly falsestarwort root, 80g of raw bighead atractylodes rhizome, 120g of fried white paeony root, 180g of white poria, 100g of dittany bark, 80g of Japanese ampelopsis root, 80g of cynanchum atratum, 100g of angelica dahurica, 100g of mulberry bark, 80g of vinegar radix bupleuri, 120g of angelica, 120g of fried red paeony root, 120g of radix rehmanniae recen, 120g of fried ligusticum wallichii, 80g of safflower, 100g of mashed peach kernel, 70g of rose, 120g of suberect spatholobus stem, 120g of raw coix seed, 180g of cooked coix seed, 180g of Chinese yam, 80g of lotus seed meat, 80g of Chinese date, 100g of raw liquorice, 70g of loofah sponge and 80g of beautiful sweetgum fruit. Decocting the above materials, removing residues, adding 200g colla Corii Asini, 300g maltose, 250g Mel (200 g xylitol for diabetic patients), and 300g yellow wine, melting, and collecting paste.
Example 6 preparation of blood-activating and face-beautifying cream formulation (VI)
120g of raw astragalus membranaceus, 180g of radix pseudostellariae, 120g of raw bighead atractylodes rhizome, 180g of fried white peony root, 120g of white poria, 80g of dittany bark, 80g of Japanese ampelopsis root, 100g of cynanchum atratum, 100g of angelica dahurica, 100g of mulberry bark, 80g of vinegar radix bupleuri, 120g of angelica sinensis, 80g of fried red peony root, 120g of radix rehmanniae recen, 180g of fried ligusticum wallichii, 100g of safflower carthamus, 80g of peach kernel paste, 50g of rose, 120g of caulis spatholobi, 180g of raw coix seed, 180g of cooked coix seed, 180g of Chinese yam, 80g of lotus seed meat, 80g of Chinese date, 80g of raw licorice, 70g of loofah sponge and 120g of beautiful sweetgum fruit. Decocting the above materials, removing residues, adding 200g colla Corii Asini, 200g maltose, 250g Mel (200 g xylitol for diabetic patients), and 250g yellow wine, melting, and collecting paste.
Example 7 preparation of a formula of the blood-activating and beauty-maintaining cream of the invention (Qiqi)
120g of raw astragalus membranaceus, 180g of radix pseudostellariae, 120g of raw bighead atractylodes rhizome, 180g of fried white peony root, 120g of white poria, 80g of dittany bark, 80g of Japanese ampelopsis root, 100g of cynanchum atratum, 100g of angelica dahurica, 100g of mulberry bark, 80g of vinegar radix bupleuri, 120g of angelica sinensis, 80g of fried red peony root, 120g of radix rehmanniae recen, 180g of fried ligusticum wallichii, 100g of safflower carthamus, 80g of peach kernel paste, 50g of rose, 180g of caulis spatholobi, 120g of raw coix seed, 180g of cooked coix seed, 120g of Chinese yam, 120g of lotus seed meat, 80g of Chinese date, 100g of raw licorice, 50g of loofah sponge and 120g of beautiful sweetgum fruit. Decocting the above materials, removing residues, adding 200g colla Corii Asini, 300g maltose, 200g Mel (for diabetic patients, xylitol 160g), and 300g yellow wine, melting, and collecting paste.
Example 8 preparation of a formula of the blood-activating and beauty-maintaining cream of the invention (eight)
140g of raw astragalus membranaceus, 160g of radix pseudostellariae, 90g of raw bighead atractylodes rhizome, 160g of fried white peony root, 140g of white poria, 100g of dittany bark, 80g of Japanese ampelopsis root, 100g of cynanchum atratum, 80g of angelica dahurica, 100g of mulberry bark, 80g of vinegar radix bupleuri, 160g of angelica sinensis, 90g of fried red peony root, 110g of radix rehmanniae recen, 140g of fried ligusticum wallichii, 100g of safflower carthamus, 80g of peach kernel paste, 70g of rose, 140g of caulis spatholobi, 160g of raw coix seed, 140g of cooked coix seed, 160g of Chinese yam, 90g of lotus seed meat, 100g of Chinese date, 80g of raw licorice, 70g of loofah sponge and 90g of beautiful sweetgum fruit. Decocting the above materials, removing residues, adding concentrated decoction into 280g of DONGcolla Corii Asini, 220g of maltose, 280g of Mel (224 g of xylitol for diabetic patients), and 280g of yellow wine, melting, and collecting paste.
Example 9 preparation of a formula of blood-activating and skin-caring cream according to the invention (nine)
160g of raw astragalus membranaceus, 140g of radix pseudostellariae, 110g of raw bighead atractylodes rhizome, 140g of fried white peony root, 160g of white poria, 80g of cortex dictamni, 100g of radix ampelopsis, 80g of cynanchum atratum, 100g of radix angelicae, 80g of white mulberry root-bark, 100g of vinegar radix bupleuri, 140g of angelica sinensis, 110g of fried red peony root, 90g of radix rehmanniae recen, 160g of fried ligusticum wallichii, 80g of safflower carthamus, 100g of peach kernel paste, 50g of rose, 180g of caulis spatholobi, 120g of raw coix seed, 180g of cooked coix seed, 120g of Chinese yam, 120g of lotus seed meat, 80g of Chinese date, 100g of raw liquorice, 50g of loofah sponge and 120g of beautiful sweetgum fruit. Decocting the above materials, removing residues, adding 200g colla Corii Asini, 300g maltose, 200g Mel (for diabetic patients, xylitol 160g), and 300g yellow wine, melting, and collecting paste.
Example 10 preparation of a formula of blood-activating and skin-caring cream according to the invention (ten)
160g of raw astragalus membranaceus, 140g of radix pseudostellariae, 110g of raw bighead atractylodes rhizome, 140g of fried white peony root, 160g of white poria, 80g of dittany bark, 100g of radix ampelopsis, 80g of cynanchum atratum, 100g of radix angelicae, 80g of white mulberry root-bark, 100g of vinegar radix bupleuri, 140g of angelica sinensis, 110g of fried red peony root, 90g of radix rehmanniae recen, 160g of fried ligusticum wallichii, 80g of safflower carthamus, 100g of mashed peach kernel, 50g of rose, 160g of caulis spatholobi, 140g of raw coix seed, 160g of cooked coix seed, 140g of Chinese yam, 110g of lotus seed meat, 80g of Chinese date, 100g of raw licorice, 50g of loofah and 110g of beautiful sweetgum fruit. The medicines are decocted for thick time, dregs are removed, thick juice is taken to be added with 220g of donkey-hide gelatin, 280g of maltose, 220g of white honey (176 g of xylitol for diabetics) and 220g of yellow wine, and the mixture is melted to obtain paste.
Example 11 clinical experiments of the formula of the blood-activating and beauty-maintaining cream for conditioning qi-stagnation and blood-stasis constitutions of women with the unbalanced constitutions
1 data and method
1.1 clinical data
120 of patients who were in the pre-illness outpatient service at the secondary eosin hospital of Shanghai medical university during the period from 11 months in 2019 to 12 months in 2020 were selected as study subjects. 120 subjects were divided into three groups, 40 each, by using a random number table method, including the original plaster formula group, the plaster formula group of the present application, and the Xuefu Zhuyu Tang group. The age range of the original ointment formula is 22-50 years, the average age is 42.00 +/-6.29 years, and the integral of symptoms of qi depression and blood stasis is 48.18 +/-12.14 minutes; the formula of the ointment is 23-50 years old, the average age is 41.78 +/-7.23 years old, and the integral of symptoms of qi depression and blood stasis is 48.20 +/-10.10 points; the age range of the Xuefu Zhuyu decoction group is 23-49 years, the average age is 40.75 +/-7.54 years, and the integral of symptoms of qi depression and blood stasis is 46.45 +/-11.56. The comparative difference of the average age and the integral of the symptoms of qi depression and blood stasis of the three groups does not have statistical significance and is comparable.
1.2 inclusion criteria
The patients aged 18-50 years are in accordance with the judgment standards of 9 constitutions in the classification and judgment of traditional Chinese medical constitution (patients with chronic diseases such as hypertension, diabetes, chronic gastropathy and the like are merged, and patients taking fixed medicines during taking a paste formula are in accordance with the inclusion standards), except for peace and high quality.
1.3 exclusion criteria
Patients with severe diseases of the liver, brain, kidney, heart and hematopoietic system, as well as psychiatric disorders; pregnant or lactating women; is attending other clinical trial observers; other clinical testers are participated in the same period, the study is not participated in the whole period, and the study is not taken according to the prescription.
1.4 methods of treatment
The original paste formula comprises: the original formula of the blood-activating face-beautifying cream is taken, and the basic formula comprises the following components: 90g of vinegar-processed radix bupleuri, 90g of Guangdong radix curcumae, 150g of fried red peony root, 90g of peach kernel paste, 60g of grass safflower, 150g of fried rhizoma ligustici wallichii, 150g of whole angelica, 150g of fried white peony root, 60g of white poria, 150g of Japanese ampelopsis root, 100g of fried bighead atractylodes rhizome, 150g of cynanchum atratum, 100g of dittany bark, 100g of mulberry bark, 90g of prepared rehmannia root, 60g of Chinese rose flower, 60g of rose, 200g of uncooked cooked coix seed, 90g of raw licorice, 90g of Guangdong radix curcumae, 100g of red date, 100g of walnut meat, 100g of lotus seed meat, 100g of longan pulp and 100g of black sesame. The medicines are decocted in a thick mode, dregs are removed, 300g of donkey-hide gelatin, 500g of white honey (400 g of xylitol for diabetics) and 500g of yellow wine are added into thick juice, and melting is carried out to obtain paste. For patients with qi deficiency, adding white Ginseng radix 100g, radix Codonopsis 100g, and radix astragali Preparata 100g respectively; colla Cornus Cervi is selected for patients with yang deficiency; 100g of scutellaria baicalensis and 100g of coptis chinensis can be added for patients with heat; 100g of divaricate saposhnikovia root is added for patients who are easy to catch cold; for patients with body fluid deficiency, radix Panacis Quinquefolii 100g, radix Adenophorae 100g, radix Glehniae 100g, radix Ophiopogonis 100g, and herba Dendrobii 100g can be added; for patients with chronic diseases and requiring wind dispelling and collaterals dredging, Scolopendra 100g and Scorpio 80g can be added; for patients with constipation, fructus Cannabis 100g and fructus Aurantii Immaturus 100g are added; 150g of platycladi seed, 100g of spina date seed, 100g of roselle, 120g of cortex albiziae, 100g of tuber fleeceflower stem, 100g of calcined magnetite and 100g of dens draconis are added for people with insomnia; for patients with waist soreness, 100g of Eucommiae cortex, 80g of radix Achyranthis bidentatae, 100g of herba Taxilli, and 100g of rhizoma Cibotii can be added.
The paste formula of the application: 150g of raw astragalus membranaceus, 150g of radix pseudostellariae, 100g of raw bighead atractylodes rhizome, 150g of fried white peony root, 150g of white poria, 90g of dittany bark, 90g of Japanese ampelopsis root, 90g of cynanchum atratum, 90g of angelica dahurica, 90g of mulberry bark, 90g of vinegar radix bupleuri, 150g of angelica sinensis, 100g of fried red peony root, 100g of radix rehmanniae recen, 150g of fried ligusticum wallichii, 90g of safflower carthamus, 90g of peach kernel paste, 60g of rose, 150g of caulis spatholobi, 150g of raw coix seed, 150g of cooked coix seed, 150g of Chinese yam, 100g of lotus seed meat, 90g of Chinese date, 90g of raw licorice, 60g of loofah sponge and 100g of beautiful sweetgum fruit. Decocting the above materials, removing residues, adding 250g of colla Corii Asini, 250g of maltose, 250g of Mel (200 g of xylitol for diabetic patients), and 250g of yellow wine, melting, and collecting paste.
Xuefu Zhuyu Tang group: 120g of peach kernel, 90g of safflower, angelica, radix rehmanniae recen and achyranthes bidentata, 45g of ligusticum wallichii and platycodon grandiflorum, 60g of red paeony root, fructus aurantii and liquorice and 30g of radix bupleuri. Decocting the above materials, removing residues, adding 250g of colla Corii Asini, 250g of maltose, 250g of Mel (200 g of xylitol for diabetic patients), and 250g of yellow wine, melting, and collecting paste.
The above ointment is taken 25g before or after winter solstice, and contains 14g of raw materials except maltose, Mel and yellow wine. The composition is administered with boiling water in the morning and evening for 60 days. During the period of eating, drinking wine, smoking, drinking strong tea, drinking coffee, eating irritant food and raw radish are avoided.
1.4 Observation index
According to the qi depression and blood stasis related symptom integral table, the qi depression and blood stasis related symptom integral before and after intervention of a subject is counted so as to reflect the intervention effect of the ointment formula on the qi depression and blood stasis physique of the subject.
TABLE 1 integral table (points) of symptoms related to qi depression and blood stasis
Figure BDA0002948867050000081
Figure BDA0002948867050000091
1.5 clinical efficacy
Refer to the "clinical research guidelines for new Chinese drugs":
and (3) healing: clinical symptoms and physical signs of the traditional Chinese medicine disappear or basically disappear, and the symptom integral is reduced by more than or equal to 90 percent;
the effect is shown: the clinical symptoms and physical signs of the traditional Chinese medicine are improved, and the symptom integral is reduced by more than or equal to 70 percent;
the method has the following advantages: the clinical symptoms and physical signs of the traditional Chinese medicine are improved, and the symptom integral is reduced by more than or equal to 30 percent;
and (4) invalidation: the clinical symptoms and physical signs of the traditional Chinese medicine are not obviously improved or even aggravated, and the symptom integral is reduced by less than 30 percent.
Total effective rate ═ number of recovery cases + number of significant cases + number of effective cases)/total cases ] × 100%.
1.6 statistical methods
Data were processed using SPSS 18.0 statistical software. Measure data to
Figure DA00029488670532176303
Showing that the matched sample t test is adopted for comparison in each index group before and after treatment, and the independent sample t test is adopted for comparison among groups; the comparison of the count data adopts chi2And (6) checking. P < 0.05 indicates that the difference is statistically significant.
2 results
2.1 integral comparison of symptoms related to qi depression and blood stasis before and after treatment
The symptoms of qi depression and blood stasis before and after treatment are shown in Table 2. After treatment, the integral of symptoms related to qi depression and blood stasis of each group is reduced, and compared with the integral before treatment, the difference has significance (P is less than 0.05); compared with the treatment groups, the integral of symptoms related to qi depression and blood stasis of the plaster formula group is obviously lower than that of the original plaster formula group and the blood stasis removing decoction group, and the difference has statistical significance (P is less than 0.05), which indicates that the effect of improving qi depression and blood stasis is most obvious.
TABLE 2 score comparison of symptoms related to qi stagnation and blood stasis before and after treatment
Figure BDA0002948867050000092
Figure BDA0002948867050000101
Note: p <0.05 compared to pre-treatment; compared to the cream formula group of the present application, # P < 0.05.
2.2 comparison of Total effective rates of groups
The total effective rate of the original plaster formula group is 65.00%, the total effective rate of the plaster formula group is 95.00%, the total effective rate of the blood stasis removing decoction group is 57.50%, and the total effective rate of the plaster formula group is obviously higher than that of the other two groups (P < 0.05).
TABLE 3 comparison of Total effective rates of the groups
Figure BDA0002948867050000102
Note: p <0.05 compared to the cream formula group of the present application.
The above description is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, several modifications and additions can be made without departing from the method of the present invention, and these modifications and additions should also be regarded as the protection scope of the present invention.

Claims (7)

1. The blood circulation promoting and face beautifying cream formula is characterized by being prepared from the following raw material medicines in parts by weight: 180 portions of raw astragalus root, 180 portions of radix pseudostellariae, 80 to 120 portions of raw rhizoma atractylodis macrocephalae, 180 portions of fried white paeony root, 180 portions of white poria, 80 to 100 portions of cortex dictamni, 80 to 100 portions of ampelopsis japonica, 80 to 100 portions of cynanchum atratum, 80 to 100 portions of angelica dahurica, 80 to 100 portions of mulberry bark, 80 to 100 portions of vinegar radix bupleuri, 180 portions of angelica sinensis, 80 to 120 portions of fried red paeony root, 80 to 120 portions of radix rehmanniae recen, 180 portions of fried rhizoma ligustici wallichii, 80 to 100 portions of safflower carthamus, 80 to 100 portions of peach kernel paste, 50 to 70 portions of rose, 180 portions of caulis spatholobi, 180 portions of raw semen coicis, 180 portions of cooked semen coicis, 180 portions of rhizoma dioscoreae, 80 to 120 portions of lotus seed, 80 to 100 portions of Chinese date, 80 to 100 portions of raw licorice, 50 to 70 portions of retinervus luffae fructus, and the like, 80-120 parts of beautiful sweetgum fruit, 200-300 parts of Dong donkey-hide gelatin, 200-300 parts of maltose, 200-300 parts of white honey and 200-300 parts of yellow wine.
2. The blood circulation promoting and skin caring ointment formula according to claim 1, which is prepared from the following raw material medicines in parts by weight: 160 parts of crude astragalus 140-, 90-110 parts of beautiful sweetgum fruit, 280 parts of Dong donkey-hide gelatin, 280 parts of maltose, 280 parts of white honey and 280 parts of yellow wine.
3. The blood circulation promoting and skin caring ointment formula according to claim 2, characterized in that the formula is prepared from the following raw material medicines in parts by weight: 150 parts of raw astragalus membranaceus, 150 parts of radix pseudostellariae, 100 parts of raw bighead atractylodes rhizome, 150 parts of fried white peony root, 150 parts of white poria, 90 parts of cortex dictamni, 90 parts of radix ampelopsis, 90 parts of cynanchum atratum, 90 parts of radix angelicae, 90 parts of cortex mori, 90 parts of vinegar radix bupleuri, 150 parts of angelica sinensis, 100 parts of fried red peony root, 100 parts of radix rehmanniae recen, 150 parts of fried ligusticum wallichii, 90 parts of safflower carthamus, 90 parts of peach kernel paste, 60 parts of rose, 150 parts of caulis spatholobi, 150 parts of raw coix seed, 150 parts of cooked coix seed, 150 parts of Chinese yam, 100 parts of lotus seed, 90 parts of Chinese date, 90 parts of raw licorice, 60 parts of loofah sponge, 100 parts of beautiful sweetgum fruit, 250 parts of donkey-hide gelatin, 250 parts of sugar syrup, 250 parts of white honey and 250 parts of yellow wine.
4. The blood-activating face-beautifying cream formulation according to any one of claims 1 to 3, characterized by being prepared by the following method: decocting raw materials except colla Corii Asini, maltose, Mel and yellow wine, removing residue, adding concentrated juice into colla Corii Asini, maltose, Mel and yellow wine, melting, and collecting paste.
5. The blood circulation-promoting and skin-caring cream according to any one of claims 1 to 3, further comprising a pharmaceutically acceptable carrier.
6. The preparation method of the blood-activating face-beautifying paste prescription according to any one of claims 1 to 3, characterized in that the raw material medicines except the Dong donkey-hide gelatin, the maltose, the white honey and the yellow wine are taken, the thick juice is taken, the Dong donkey-hide gelatin, the maltose, the white honey and the yellow wine are added, and the paste is obtained after melting.
7. Use of the blood-activating face-beautifying cream formula of any one of claims 1 to 3 in the preparation of health-care products for conditioning female constitution of qi depression and blood stasis.
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