CN112569291A

CN112569291A - Pharmaceutical composition for polycystic ovarian syndrome and preparation method thereof

Info

Publication number: CN112569291A
Application number: CN202011403329.4A
Authority: CN
Inventors: 翟佳佳; 郝桂敏; 张琳
Original assignee: Second Hospital of Hebei Medical University
Current assignee: Second Hospital of Hebei Medical University
Priority date: 2020-12-04
Filing date: 2020-12-04
Publication date: 2021-03-30

Abstract

The invention discloses a pharmaceutical composition for polycystic ovarian syndrome and a preparation method thereof, wherein the pharmaceutical composition comprises a daidzein extracting solution and a traditional Chinese medicine decoction according to the weight parts of 1: 1, and the preparation method comprises the following steps: the method comprises the following steps: preparing a daidzein extracting solution, soaking 200 parts of soybeans in clear water for 4 hours, adding 500 parts of water after the soybeans are foamed, and grinding the soybeans into soybean milk by using a soybean milk machine to obtain the daidzein extracting solution; step two: preparing a Chinese medicinal decoction, wherein one of the two tripe decoction of fructus Lycii, pregnancy promoting decoction, black bean glutinous rice porridge or folium Artemisiae Argyi brown sugar pouch egg decoction is selected. The total effective rate (91.78%) of the patients is higher than that of the control group (71.3%), and P is less than 0.05; the embodiment has the advantages that the daidzein with the clinical total curative effect and the traditional Chinese medicine decoction are combined with the recuperation-Du acupuncture therapy to treat the polycystic ovarian syndrome infertility with the clinical curative effect, the symptoms of the patient are improved, the recovery is good, the 1-year pregnancy rate of the patient can be improved, and the adverse reaction of the patient is reduced.

Description

Pharmaceutical composition for polycystic ovarian syndrome and preparation method thereof

Technical Field

The invention relates to the field of medicines, in particular to a pharmaceutical composition for polycystic ovarian syndrome and a preparation method thereof.

Background

The infertility caused by polycystic ovarian syndrome is a common gynecological disease, the pathogenesis of the disease is complex, the disease is influenced by abnormal endocrine and metabolism, and the clinical symptoms are chronic anovulation and hyperandrogenism, abnormal menstruation or amenorrhea, infertility and the like. Research shows that the incidence rate of the infertility of polycystic ovarian syndrome of women of childbearing age in China is about 5.00-10.00%, and the infertility accounts for 75.00% of the anovulatory infertility. Along with the change of living habits and living environments of people, the incidence rate of polycystic ovarian syndrome infertility rises year by year, which harms the health of patients and brings heavy burden to families.

At present, the western medicine clinical treatment of polycystic ovarian syndrome infertility adopts hormone treatment to promote ovulation and reduce androgen, but has certain adverse reaction and is not suitable for long-term application. Therefore, new treatment schemes for the polycystic ovarian syndrome infertility are continuously researched clinically so as to improve the treatment effect and promote the rehabilitation of patients.

Disclosure of Invention

The invention aims to provide a pharmaceutical composition for polycystic ovarian syndrome and a preparation method thereof, and aims to solve the problem of certain adverse reaction in long-term application in the background technology.

In order to achieve the purpose, the invention provides the following technical scheme:

a pharmaceutical composition for polycystic ovarian syndrome comprises a daidzein extracting solution and a traditional Chinese medicine decoction, wherein the daidzein extracting solution and the traditional Chinese medicine decoction are prepared from the following raw materials in parts by weight of 1: 1, and mixing.

As a further scheme of the invention: the traditional Chinese medicine decoction is one of a medlar-tripe soup, a pregnancy promoting soup, a black bean-glutinous rice porridge or a folium artemisiae argyi-brown sugar-pouch egg soup.

As a further scheme of the invention: the wolfberry fruit and tripe soup comprises the following raw materials in parts by weight: 5-15 parts of medlar, 50-150 parts of pork tripe, 20-40 parts of fish tripe and 200 parts of water.

As a further scheme of the invention: the pregnancy promoting soup comprises the following raw materials in parts by weight: 5-10 parts of herba epimedii, 4-8 parts of bighead atractylodes rhizome, 5-10 parts of prepared rehmannia root, 6-10 parts of radix astragali preparata, 5-10 parts of salvia miltiorrhiza, 10-20 parts of angelica, 5-10 parts of amethyst, 4-8 parts of morinda officinalis, 4-8 parts of rhizoma cyperi, 4-8 parts of radix bupleuri, 4-8 parts of poria cocos, 4-8 parts of medicinal cyathula root, 4-8 parts of curcuma zedoary, 5-10 parts of rhizoma sparganii and 200 parts of water.

As a further scheme of the invention: the black bean glutinous rice porridge comprises the following raw materials in parts by weight: 20-40 parts of black beans, 50-70 parts of sticky rice and 200 parts of water.

As a further scheme of the invention: the folium artemisiae argyi brown sugar pouch egg soup comprises the following raw materials in parts by weight: 20-40 parts of aged and dried folium artemisiae argyi, 5-10 parts of brown sugar, 10-20 parts of eggs and 100 parts of water.

A preparation method of a pharmaceutical composition for polycystic ovarian syndrome comprises the following steps:

the method comprises the following steps: preparing a daidzein extracting solution, soaking 200 parts of soybeans in clear water for 4 hours, adding 500 parts of water after the soybeans are foamed, and grinding the soybeans into soybean milk by using a soybean milk machine to obtain the daidzein extracting solution;

step two: preparing a traditional Chinese medicine decoction, selecting one of a medlar two tripe soup, a pregnancy-assisting soup, a black bean glutinous rice porridge or a folium artemisiae argyi brown sugar pouch egg soup, wherein:

preparing medlar and two tripe soup: cleaning pork tripe, slicing, boiling fish tripe, putting the boiled fish tripe and medlar together in a pot, adding a proper amount of clear water, and boiling the fish tripe until the pork tripes are well cooked;

② preparation of pregnancy promoting decoction: adding water into herba Epimedii, Atractylodis rhizoma, radix rehmanniae Preparata, radix astragali Preparata, Saviae Miltiorrhizae radix, Fluoritum, radix Morindae officinalis, rhizoma Cyperi, bupleuri radix, Poria, radix Cyathulae, Curcumae rhizoma and rhizoma Sparganii according to a certain proportion, boiling with strong fire, decocting with slow fire for 50 min, adding radix Angelicae sinensis, decocting for 10 min again, and taking out the decoction;

preparation of black bean glutinous rice porridge: cleaning semen Sojae Atricolor and Oryza Glutinosa, placing in a pot, adding 300ml of daidzein extract, cooking with slow fire to obtain porridge, and cooking with slow fire to obtain porridge;

preparing the artemisia leaf brown sugar pouch egg soup: boiling folium Artemisiae Argyi in cold water with strong fire, decocting with slow fire for 15-20 min, draining folium Artemisiae Argyi, adding 1-2 eggs, collecting egg white, turning off fire, and adding brown sugar.

Compared with the prior art, the invention has the beneficial effects that: the total effective rate (91.78%) of the patients is higher than that of the control group (71.3%), and P is less than 0.05; the embodiment has the advantages that the daidzein with the clinical total curative effect and the traditional Chinese medicine decoction are combined with the recuperation-Du acupuncture therapy to treat the polycystic ovarian syndrome infertility with the clinical curative effect, the symptoms of the patient are improved, the recovery is good, the 1-year pregnancy rate of the patient can be improved, and the adverse reaction of the patient is reduced.

Detailed Description

The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

Control group 1

Western conventional therapy for patients: the letrozole is orally taken 1 time a day, 2.5mg each time, and 5 days for 1 treatment course beginning on the 3 rd day of the menstrual cycle of a patient, and the treatment course is 4 treatment courses continuously.

Control group 2

The patient combines pregnancy-assisting decoction and the recuperating and Du-acupuncture therapy treatment: the patient starts to take pregnancy promoting decoction on day 3 of menstrual cycle for treatment, and takes the decoction warm in the morning and evening for 14 days continuously, which is 1 treatment course and 4 treatment courses continuously.

The governing and conception channels dredging acupuncture therapy: the main points of Zhongwan, Qihai, Guanyuan, Mingmen, Zhongji, Yaoshu, and Yaoyangguan; point-matching Shenshu, Yinjiao, Sanyinjiao, Taixi, Qixue, Zusanli, Ganshu and Taichong; the filiform needle of 0.30mm multiplied by 25mm is inserted rapidly without remaining needle; adopts the method of mild reinforcing and reducing acupuncture, the treatment time is every other day after the patient has clear menstruation, the acupuncture is carried out for 4 times as a treatment course, and 4 treatment courses are continuously treated.

Control group 3

The patients are treated by the regulation and supervision acupuncture therapy: the main points of Zhongwan, Qihai, Guanyuan, Mingmen, Zhongji, Yaoshu, and Yaoyangguan; point-matching Shenshu, Yinjiao, Sanyinjiao, Taixi, Qixue, Zusanli, Ganshu and Taichong; the filiform needle of 0.30mm multiplied by 25mm is inserted rapidly without remaining needle; adopts the method of mild reinforcing and reducing acupuncture, the treatment time is every other day after the patient has clear menstruation, the acupuncture is carried out for 4 times as a treatment course, and 4 treatment courses are continuously treated.

Example 1

The patients are treated by combining the daidzein extracting solution and the pregnancy promoting decoction on the basis of the treatment of the control group: soaking 200 parts of soybeans in clean water for 4 hours, adding 500 parts of water after the soybeans are foamed, making the soybeans into soybean milk by using a soybean milk machine to obtain a daidzein extracting solution, drinking 300ml of the soybean milk every day, and starting to take the pharmaceutical composition for treatment on the 3 rd day of the menstrual cycle by a patient, namely mixing 100ml of each of the assisted pregnancy soup and the daidzein extracting solution to obtain a mixed medicament, taking the mixture warm in the morning and at night, continuously taking the medicine for 14 days, and continuously treating for 4 treatment courses with 1 course.

step two: a traditional Chinese medicine decoction, wherein:

the pork tripe is prepared by cleaning and slicing the pork tripe, boiling the pork tripe and medlar, adding a proper amount of clear water, and boiling the boiled pork tripe and medlar until the pork tripes are well cooked.

Example 2

step two: a traditional Chinese medicine decoction, wherein:

10 parts of medlar, 100 parts of pork tripe, 30 parts of fish tripe and 150 parts of water, wherein the pork tripe is cleaned, sliced, the fish tripe is boiled, the fish tripe and the medlar are put into a pot, and a proper amount of clear water is added to the pot to be boiled till the two tripes are well cooked.

Example 3

step two: a traditional Chinese medicine decoction, wherein:

15 parts of medlar, 150 parts of pork tripe, 40 parts of fish tripe and 200 parts of water, the pork tripe is washed clean and sliced, the fish tripe is boiled, the fish tripe and the medlar are put into a pot, and a proper amount of clear water is added to the pot until the two tripes are well cooked.

Example 4

The patients are treated by combining the daidzein extracting solution and the folium artemisiae argyi brown sugar poached egg soup on the basis of the treatment of the control group: soaking 200 parts of soybeans in clean water for 4 hours, adding 500 parts of water after foaming the soybeans, beating the soybeans into soybean milk by using a soybean milk machine to obtain a daidzein raw extract, drinking the soybean milk for 300ml per day, putting 10 g of argy wormwood leaves into cold water, boiling the argy wormwood leaves with strong fire, then boiling the argy wormwood leaves with slow fire for 15 to 20 minutes, draining the argy wormwood leaves, adding 1 to 2 eggs (the eggs are different in calling law in each place of the poached eggs, and the eggs are not stirred up), closing the fire after gathering the egg white, adding brown sugar, mixing the soup and the daidzein raw extract each 100ml to obtain a mixed medicament, continuously taking the mixture for 10 days, and continuously treating 4 treatment courses for 1 treatment.

step two: a traditional Chinese medicine decoction, wherein:

the folium artemisiae argyi brown sugar pouch egg soup comprises the following raw materials in parts by weight: 20 parts of aged and dried folium artemisiae argyi, 5 parts of brown sugar, 10 parts of eggs and 100 parts of water.

Preparing the folium artemisiae argyi brown sugar pouch egg soup: boiling folium Artemisiae Argyi in cold water with strong fire, decocting with slow fire for 15-20 min, draining folium Artemisiae Argyi, adding 1-2 eggs, collecting egg white, turning off fire, and adding brown sugar.

Example 5

step two: a traditional Chinese medicine decoction, wherein:

the folium artemisiae argyi brown sugar pouch egg soup comprises the following raw materials in parts by weight: 30 parts of aged dry moxa, 8 parts of brown sugar, 15 parts of eggs and 150 parts of water.

Example 6

step two: a traditional Chinese medicine decoction, wherein:

the folium artemisiae argyi brown sugar pouch egg soup comprises the following raw materials in parts by weight: 40 parts of aged and dried folium artemisiae argyi, 10 parts of brown sugar, 20 parts of eggs and 200 parts of water.

Example 7

The patients are treated by combining the daidzein extracting solution and the pregnancy promoting decoction on the basis of the treatment of the control group: soaking 200 parts of soybeans in clean water for 4 hours, adding 500 parts of water after the soybeans are foamed, and pulping the soybeans into soybean milk by using a soybean milk machine to obtain a daidzein extracting solution, wherein the soybean milk drinking amount is 300ml per day, and a patient combines the pregnancy-assisting soup with the recuperation and governor meridian-dredging acupuncture therapy for treatment: the patient starts to take 100ml of mixed medicament of daidzein extract of pregnancy promoting decoction on day 3 of menstrual cycle, and takes warm in the morning and evening for 14 days as 1 treatment course and 4 treatment courses.

step two: a traditional Chinese medicine decoction, wherein:

the pregnancy promoting soup comprises the following raw materials in parts by weight: 5 parts of herba epimedii, 4 parts of bighead atractylodes rhizome, 5 parts of prepared rehmannia root, 6 parts of radix astragali preparata, 5 parts of salvia miltiorrhiza, 10 parts of angelica, 5 parts of amethyst, 4 parts of morinda officinalis, 4 parts of rhizoma cyperi, 4 parts of radix bupleuri, 4 parts of poria cocos, 4 parts of medicinal cyathula root, 4 parts of curcuma zedoary, 5 parts of rhizoma sparganii and 100 parts of water.

Preparing pregnancy promoting decoction: according to the material ratio, the epimedium herb, the largehead atractylodes rhizome, the prepared rehmannia root, the roasted astragalus root, the red sage root, the amethyst, the morinda root, the nutgrass galingale rhizome, the Chinese thorowax root, the Indian buead, the medicinal cyathula root, the zedoary and the common burreed rhizome are added with water and boiled by big fire, then the mixture is decocted by slow fire for 50 minutes, and then the Chinese angelica is put into the mixture and decocted again for 10 minutes, thus.

Example 8

step two: a traditional Chinese medicine decoction, wherein:

the pregnancy promoting soup comprises the following raw materials in parts by weight: 8 parts of epimedium, 6 parts of bighead atractylodes rhizome, 8 parts of prepared rehmannia root, 8 parts of roasted astragalus root, 8 parts of salvia miltiorrhiza, 15 parts of angelica, 8 parts of amethyst, 6 parts of morinda officinalis, 6 parts of rhizoma cyperi, 6 parts of radix bupleuri, 6 parts of poria cocos, 6 parts of medicinal cyathula root, 6 parts of curcuma zedoary, 8 parts of rhizoma sparganii and 150 parts of water.

Example 9

The patients are treated by combining the daidzein extracting solution and the pregnancy promoting decoction on the basis of the treatment of the control group: soaking 200 parts of soybeans in clean water for 4 hours, adding 500 parts of water after the soybeans are foamed, beating the soybeans into soybean milk by using a soybean milk machine to obtain a daidzein extracting solution, drinking 300 milliliters of the soybean milk every day, combining the proconception-assisting soup with a regulation and supervision acupuncture therapy for treatment, starting taking 100ml of daidzein extracting solution of the proconception-assisting soup by the patient on the 3 rd day of the menstrual cycle, respectively, carrying out warm taking in the morning and the evening, continuously taking medicine for 14 days, and carrying out 4 treatment courses continuously.

step two: a traditional Chinese medicine decoction, wherein:

the pregnancy promoting soup comprises the following raw materials in parts by weight: 10 parts of herba epimedii, 8 parts of bighead atractylodes rhizome, 10 parts of prepared rehmannia root, 10 parts of radix astragali preparata, 10 parts of salvia miltiorrhiza, 20 parts of angelica, 10 parts of amethyst, 8 parts of morinda officinalis, 8 parts of rhizoma cyperi, 8 parts of radix bupleuri, 8 parts of poria cocos, 8 parts of medicinal cyathula root, 8 parts of curcuma zedoary, 10 parts of rhizoma sparganii and 200 parts of water.

Example 10

The patients are treated by combining the daidzein extracting solution and the black bean glutinous rice porridge on the basis of the treatment of the control group: soaking 200 parts of soybeans in clean water for 4 hours, adding 500 parts of water after the soybeans are foamed, making the soybeans into soybean milk by using a soybean milk machine to obtain a daidzein extracting solution, drinking the soybean milk at 300ml per day, washing the black soybeans and glutinous rice clean, putting the cleaned black soybeans and the glutinous rice in a pot, adding 100ml of the daidzein extracting solution, mixing, cooking the mixture into porridge with slow fire, taking the porridge daily for 10 days, and taking 4 treatment courses continuously as 1 treatment course.

step two: a traditional Chinese medicine decoction, wherein:

the black bean glutinous rice porridge comprises the following raw materials in parts by weight: 20 parts of black beans and 50 parts of glutinous rice.

Preparing black bean glutinous rice porridge: cleaning semen Sojae Atricolor and Oryza Glutinosa, placing in a pot, adding 100ml of daidzein extract, cooking with slow fire to obtain porridge, and cooking with slow fire to obtain porridge.

Example 11

The patients are treated by combining the daidzein extracting solution and the black bean glutinous rice porridge on the basis of the treatment of the control group: soaking 200 parts of soybeans in clear water for 4 hours, adding 500 parts of water after the soybeans are foamed, making the soybeans into soybean milk by using a soybean milk machine to obtain a daidzein extracting solution, drinking the soybean milk at 300ml per day, washing the black soybeans and glutinous rice clean, putting the cleaned black soybeans and the glutinous rice in a pot, adding 200ml of the daidzein extracting solution, mixing, cooking the mixture into porridge with slow fire, taking the porridge daily for 10 days, and taking 4 treatment courses continuously as 1 treatment course.

step two: a traditional Chinese medicine decoction, wherein:

the black bean glutinous rice porridge comprises the following raw materials in parts by weight: 30 parts of black beans and 60 parts of glutinous rice.

Preparing black bean glutinous rice porridge: cleaning semen Sojae Atricolor and Oryza Glutinosa, placing in a pot, adding 200ml of daidzein extract, cooking with slow fire to obtain porridge, and cooking with slow fire to obtain porridge.

Example 12

The patients are treated by combining the daidzein extracting solution and the black bean glutinous rice porridge on the basis of the treatment of the control group: soaking 200 parts of soybeans in clean water for 4 hours, adding 500 parts of water after the soybeans are foamed, making the soybeans into soybean milk by using a soybean milk machine to obtain a daidzein extracting solution, drinking the soybean milk at 300ml per day, washing the black soybeans and glutinous rice clean, putting the cleaned black soybeans and the glutinous rice in a pot, adding 300ml of the daidzein extracting solution, mixing, cooking the mixture into porridge with slow fire, taking the porridge daily for 10 days, and taking 4 treatment courses continuously as 1 treatment course.

step two: a traditional Chinese medicine decoction, wherein:

the black bean glutinous rice porridge comprises the following raw materials in parts by weight: 40 parts of black beans and 70 parts of glutinous rice.

Preparing black bean glutinous rice porridge: cleaning semen Sojae Atricolor and Oryza Glutinosa, placing in a pot, adding 300ml of daidzein extract, cooking with slow fire to obtain porridge, and cooking with slow fire to obtain porridge.

Observation indexes are as follows:

the curative effect is standard: recovery-the patient's menstruation returns to normal, B-ultrasonic shows ovulation or pregnancy, the curative effect index of Chinese medicine symptom is more than 90.00%; the effect is obvious, the menstruation of a patient is close to normal, the B ultrasonic indicates that the follicular development is basically normal, and the curative effect index of the traditional Chinese medicine syndrome is more than 70.00 percent and less than 90.00 percent; effective, after the patient is treated, the menstruation lasts for 1 time in 2-3 months, the B-ultrasonic shows that the follicle is enlarged compared with the treatment precursor, and the curative effect index of the traditional Chinese medicine syndrome is more than 30.00 percent and less than 70.00 percent; ineffectiveness-the above criteria were not met after treatment. Total effective rate = cure rate + significant efficiency + effective rate.

② adopting color Doppler ultrasound to measure the volume of endometrium and ovary before and after two groups of patients are treated

The statistical method comprises the following steps:

statistical analysis is carried out by adopting SPSS22.0 software, the counting data adopts inspection, the metering data adopts t inspection, and P is less than 0.05.

The curative effect comparison of patients:

TABLE 1 comparison of therapeutic efficacy (n;%) in six groups of patients after treatment

Through test analysis, compared LH, FSH, LH/FSH and T in the seven groups of serum sex hormones before treatment, the difference has no statistical significance (P is more than 0.05), and the seven groups of serum sex hormones before treatment are proved to have comparability.

TABLE 2 two pre-treatment serum LH, FSH, LH/FSH, T comparisons

Group of	Example (b)	LH	FSH	LH/FSH	T(nmol/L)
						Control group 1	80	9.76+3.48	4.87+1.26	2.03+0.51	1.77 Earth 0.58
Control group 2	78	9.6+3.04	4.82+1.29	2.02+0.43	1.74+0.57
						Control group 3	77	11.03+3.34	4.03+1.25	1.87+0.54	1.54+0.55
Example 1	82	9.86±3.44Δ	4.91±1.22Δ	2.04±0.52Δ	1.81±0.56Δ
						Example 2	80	9.82±3.45Δ	4.96±1.23Δ	2.04±0.48Δ	1.88±0.59Δ
Example 3	77	9.87±3.36Δ	4.9±1.25Δ	2.03±0.44Δ	1.86±0.48Δ
						Example 4	81	9.8±3.27Δ	4.89±1.20Δ	2.05±0.43Δ	1.84±0.52Δ
Example 5	83	9.84±3.49Δ	4.95±1.28Δ	2.05±0.55Δ	1.86±0.56Δ
						Example 6	81	9.83±3.48Δ	4.92±1.27Δ	2.04±0.46Δ	1.83±0.53Δ
Example 7	79	9.88±3.34Δ	4.93±1.26Δ	2.04±0.43Δ	1.89±0.48Δ
						Example 8	80	9.81±3.23Δ	4.84±1.24Δ	2.06±0.44Δ	1.88±0.58Δ
Example 9	83	9.87±3.49Δ	4.95±1.24Δ	2.03±0.58Δ	1.85±0.52Δ
						Example 10	80	9.86±3.44Δ	4.96±1.23Δ	2.02±0.47Δ	1.82±0.57Δ
Example 11	76	9.82±3.31Δ	4.97±1.22Δ	2.04±0.46Δ	1.87±0.44Δ
						Example 13	84	9.83±3.28Δ	4.88±1.21Δ	2.05±0.44Δ	1.84±0.51Δ

Note: compared with the traditional Chinese medicine group, delta P > 0.05.

The clinical total curative effect is as follows: the clinical total curative effect of the control group is 71.3 percent, the clinical total curative effect of the embodiment is 91.78 percent, and the embodiment is better than the clinical total curative effect of the control group, which shows that the clinical total curative effect of the control group for treating polycystic ovarian syndrome is quite good.

The research personnel let the women participating in the experiment drink 400 ml of soybean milk every day for two months, and respectively detect the estrogen level in the body of the women during and after the drinking of the soybean milk, and the results show that the daily drinking of the soybean milk can adjust the estrogen and progestogen levels in the women, so that the secretion period is kept normal.

The efficacy of black beans is highly evaluated by people, and the Ming dynasty Li Shizhen is recorded in Ben Cao gang mu: if the black beans are eaten frequently, the diseases can be cured. The Western Aster Hospital of Chinese academy of science and science teaches that black beans can nourish liver and kidney, and the health of liver and kidney is helpful for improving vision. In addition, the black beans are rich in an antioxidant component, namely anthocyanidin and vitamin A beneficial to eyes, and the two important nutrients can relieve eye fatigue and help to prevent vision from being degraded. Wherein the mature vinegar can promote the dissolution of nutrient elements in the black beans and is beneficial to the high-efficiency intake of nutrient components. The vinegar soaked black bean is simple, firstly, a pan is prepared, black bean is put in the pan, oil is not put in the pan, the pan is fried for about 5 minutes by medium fire, and after the black bean skin is boiled, the pan is changed to small fire and is fried for 5 minutes, and people do not need to fry the black bean skin. Airing the fried black beans for 15 minutes, putting the black beans into a clean container with a cover, adding mature vinegar, soaking for about two hours, and allowing the mature vinegar to be absorbed by the black beans so as to be edible. The vinegar soaked black beans can help to inhibit visual deterioration, and are also effective in treating chronic fatigue, cold syndrome, shoulder pain, hypertension, high cholesterol and the like, which are the most easily available diseases for people working in offices.

The black beans soaked by the vinegar can be eaten the same day after being prepared, and can be stored in a refrigerator for half a year, so that the black beans can be eaten more than once. The black beans have natural sweet taste, and the black beans soaked in the vinegar are mellow in taste and relatively delicious. If the sour taste of vinegar is not favored, a small amount of honey can be added.

Egg white aggregation: it refers to the state that the egg white is gathered together and hardened after being boiled in water and does not expand outwards.

It will be evident to those skilled in the art that the invention is not limited to the details of the foregoing illustrative embodiments, and that the present invention may be embodied in other specific forms without departing from the spirit or essential attributes thereof. The present embodiments are therefore to be considered in all respects as illustrative and not restrictive, the scope of the invention being indicated by the appended claims rather than by the foregoing description, and all changes which come within the meaning and range of equivalency of the claims are therefore intended to be embraced therein.

Furthermore, it should be understood that although the present description refers to embodiments, not every embodiment may contain only a single embodiment, and such description is for clarity only, and those skilled in the art should integrate the description, and the embodiments may be combined as appropriate to form other embodiments understood by those skilled in the art.

Claims

1. A pharmaceutical composition for polycystic ovarian syndrome is characterized by comprising a daidzein extracting solution and a traditional Chinese medicine decoction, wherein the daidzein extracting solution and the traditional Chinese medicine decoction are mixed according to the weight ratio of 1: 1, and mixing.

2. The pharmaceutical composition for polycystic ovarian syndrome according to claim 1, wherein the traditional Chinese medicine decoction is one of wolfberry two-belly decoction, pregnancy promoting decoction, black bean glutinous rice porridge or folium artemisiae argyi brown sugar poached egg decoction.

3. The pharmaceutical composition for polycystic ovarian syndrome according to claim 2, wherein the wolfberry-tripe decoction comprises the following raw materials in parts by weight: 5-15 parts of medlar, 50-150 parts of pork tripe, 20-40 parts of fish tripe and 200 parts of water.

4. The pharmaceutical composition for polycystic ovary syndrome according to claim 2, wherein the pregnancy promoting decoction comprises the following raw materials, by weight, 5-10 parts of herba epimedii, 4-8 parts of rhizoma atractylodis macrocephalae, 5-10 parts of prepared rehmannia root, 6-10 parts of radix astragali preparata, 5-10 parts of radix salviae miltiorrhizae, 10-20 parts of angelica sinensis, 5-10 parts of amethyst, 4-8 parts of morinda officinalis, 4-8 parts of rhizoma cyperi, 4-8 parts of radix bupleuri, 4-8 parts of poria cocos, 4-8 parts of radix cyathulae, 4-8 parts of rhizoma zedoariae, 5-10 parts of rhizoma sparganii and 100-200 parts of water.

5. The pharmaceutical composition for polycystic ovary syndrome according to claim 2, wherein the black bean glutinous rice porridge comprises 20-40 parts of black bean, 50-70 parts of glutinous rice and 100-200 parts of water.

6. The pharmaceutical composition for polycystic ovary syndrome according to claim 2, wherein the folium artemisiae argyi brown sugar poached egg soup comprises the following raw materials in parts by weight: 20-40 parts of aged and dried folium artemisiae argyi, 5-10 parts of brown sugar, 10-20 parts of eggs and 100 parts of water.

7. A preparation method of a pharmaceutical composition for treating polycystic ovarian syndrome is characterized by comprising the following steps:

preparing medlar and two tripe soup: cleaning Gaster Sus Domestica, slicing, boiling Gaster Sus Domestica, putting together with fructus Lycii in a pot, adding clear water, and decocting until Gaster Sus Domestica and Gaster Sus Domestica are well cooked;

② preparation of pregnancy promoting decoction: adding water into herba epimedii, bighead atractylodes rhizome, prepared rehmannia root, radix astragali preparata, salvia miltiorrhiza, amethyst, morinda officinalis, rhizoma cyperi, radix bupleuri, poria cocos, medicinal cyathula root, curcuma zedoary and rhizoma sparganii according to the parts by weight, boiling with strong fire, then decocting with slow fire for 50 minutes, then putting the angelica into the decoction, decocting for 10 minutes again, and taking out the decoction for later use;

preparation of black bean glutinous rice porridge: cleaning black beans and glutinous rice, putting the black beans and the glutinous rice into a pot, and adding 1: 1, cooking the daidzein extracting solution with slow fire to obtain porridge;