CN110368475A - A kind of drug and preparation method thereof for malignant tumour early stage - Google Patents

A kind of drug and preparation method thereof for malignant tumour early stage Download PDF

Info

Publication number
CN110368475A
CN110368475A CN201910792308.7A CN201910792308A CN110368475A CN 110368475 A CN110368475 A CN 110368475A CN 201910792308 A CN201910792308 A CN 201910792308A CN 110368475 A CN110368475 A CN 110368475A
Authority
CN
China
Prior art keywords
parts
drug
malignant tumour
early stage
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
CN201910792308.7A
Other languages
Chinese (zh)
Inventor
李正欢
宋雪利
陈杨
刘昕
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine
Original Assignee
First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine filed Critical First Affiliated Hospital of Guizhou University of Traditional Chinese Medicine
Priority to CN201910792308.7A priority Critical patent/CN110368475A/en
Publication of CN110368475A publication Critical patent/CN110368475A/en
Withdrawn legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/58—Reptiles
    • A61K35/586—Turtles; Tortoises, e.g. terrapins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/618—Molluscs, e.g. fresh-water molluscs, oysters, clams, squids, octopus, cuttlefish, snails or slugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/06—Fungi, e.g. yeasts
    • A61K36/07—Basidiomycota, e.g. Cryptococcus
    • A61K36/076—Poria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258—Panax (ginseng)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/284—Atractylodes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484—Glycyrrhiza (licorice)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/539—Scutellaria (skullcap)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/74—Rubiaceae (Madder family)
    • A61K36/748—Oldenlandia or Hedyotis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/752—Citrus, e.g. lime, orange or lemon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/80—Scrophulariaceae (Figwort family)
    • A61K36/804—Rehmannia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/888—Araceae (Arum family), e.g. caladium, calla lily or skunk cabbage
    • A61K36/8888—Pinellia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8966—Fritillaria, e.g. checker lily or mission bells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/902—Sparganiaceae (Bur-reed family)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/906—Zingiberaceae (Ginger family)
    • A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/46—Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/39—Complex extraction schemes, e.g. fractionation or repeated extraction steps
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/50—Methods involving additional extraction steps
    • A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying

Abstract

The drug and preparation method thereof that the invention discloses a kind of for malignant tumour early stage, effective medicinal components effective medicinal components are made of trigone, curcuma zedoary, sun-dried ginseng, Rhizoma Atractylodis Macrocephalae, Poria cocos, radix glycyrrhizae preparata, Radix Angelicae Sinensis, peach kernel, turtle shell, oyster, Rehmannia glutinosa, white peony, fritillaria thunbergii, rhizoma pinellinae praeparata, dried orange peel, oldenlandia diffusa and Sculellaria barbata.Drug of the invention is able to suppress malignant cell growth, proliferation, transfer, promotes apoptosis with promoting the circulation of qi tonifying Qi, sign, reducing phlegm and resolving masses, the antipyretic and antidote functions of disappearing of invigorating blood circulation；It is practical for malignant tumour early treatment.

Description

A kind of drug and preparation method thereof for malignant tumour early stage
Technical field
The drug and preparation method thereof that the present invention relates to a kind of for malignant tumour early stage, belongs to the field of drug technology.
Background technique
Cancer Mortality increases year by year in recent years.If liver cancer the whole world disease incidence constantly rise, at present housing I The tumor lethal cause of disease of the 4th of state's malignant tumour and third position, seriously threatens the life and health of our people.Cervical carcinoma occupies In female malignant incidence second.According to WHO data, there are new cases 530,000 in the whole world every year, and about 250,000 women are because dying of illness It dies, wherein developing country accounts for 80%.Cases of cervical cancer about 140,000, death about 3.7 ten thousand are increased newly every year in China.Malignant tumour is China human mortality main reason dead before average life span.From the point of view of the China 2000-2011 malignant tumour related data, Disease incidence and the death rate can be significantly reduced for the primary prevention of risk factor/cause of disease, but clinical treatment is pernicious swollen to reducing Tumor somatic death rate is but without obvious contribution function.
Though modern medicine has many researchs in relation to tumour, therapeutic effect is still undesirable.Urgent need is sought from traditional medicine The method for looking for effectively treatment malignant tumour, blocks malignant tumour occurrence and development, improves life in patients, extends the service life.It is pernicious Tumor patient, ordinary circumstance is poor, and the later period is even in cachexia performance.The packet that tissue local visible borders are unclear, degree of excursion is poor Block, often companion closes on enlargement of lymph nodes.Ultrasonic examination lump and periphery blood flow signal are abundant.Malignant cell growth is rapid, invades Erosion blood vessel is transferred to whole body and interferes normal cell metabolism everywhere, causes serious physiological dysfunction.Modern medicine is for early stage Malignant tumour (not companion's DISTANT METASTASES IN) is general using operation excision, postoperative to assist or do not assist Radiotherapy chemotherapy.And malignant tumor patient The normal virtual loss of healthy tendency, it is in addition postoperative weak, often it is not resistant to Radiotherapy chemotherapy.In the patient for receiving Radiotherapy chemotherapy treatment, often occur serious Radiotherapy chemotherapy adverse reaction.Traditional medicine is not only blocking malignant tumour to occur, develop, and improves life in patients, extends the longevity Life aspect effect is significant；Also there is biggish effect in terms of reducing Radiotherapy chemotherapy intervention and reducing Radiotherapy chemotherapy damage.
Traditional medicine thinks tumour Xiang Dang Yu Disorder lump in the abdomen, accumulation, malignant sore (tumor) etc., it is believed that stagnates with poly-, the malicious heresy of qi and blood knot close Cut phase is closed.Traditional Chinese medical science great master Professor Zhou Zhongying proposes " cancer poison " theory according to more than 60 years clinical experience, and promotion is clearing heat and detoxicating and with poison Attack the method for " toxic removing " of poison.
China not only possesses pools of traditional Chinese medicine, also possesses many national medicine treasure-houses, and seedling medicine is exactly one of them.According to examining Card, seedling medicine have more than 2,000 years history so far, huge contribution are made that in terms of guarding people's health.Seedling cures important reason By one of " three opinion " --- think that human body is by energy, substance, structure composition.Energy refer to inborn creature can and it is posteriori Physiology energy；Substance refers to slurries, blood, anima etc.；Structure refers to nine big frame groups i.e. brain frame, stature, cave frame etc.." gas (weather, Popularity, ground vapour), blood, water (true water, waste water) opinion " be also its Academic Core thought.Seedling doctor thinks: energy, substance, structure and gas, Blood, water balance not normal disease i.e. " disorderly no not at disease " will occur.This has certain directive function to the interpretation of the cause, onset and process of an illness understanding of tumour, By adjusting energy, supplementation material, improve structure, the balance for adjusting qi and blood water can control tumour to a certain extent.
Therefore, it based on yin-yang theory, in conjunction with the correlation theory of seedling medicine, invents this with Heibei provincial opera yin yin, Heibei provincial opera Qi and blood, broken stasis of blood dissipate the benefits of stagnant, clearing heat and detoxicating, and the drug for malignant tumour early stage has great importance.
Summary of the invention
The drug and preparation method thereof that the object of the present invention is to provide a kind of for malignant tumour early stage.Of the invention Drug with having promoting the circulation of qi tonifying Qi, promoting blood circulation to disappear sign, reducing phlegm and resolving masses, antipyretic and antidote functions, be able to suppress malignant cell growth, Proliferation, transfer, promote apoptosis；It is practical for malignant tumour early treatment.
Technical solution of the present invention: a kind of drug for malignant tumour early stage, effective medicinal components shine composition by weight meter Calculate, by 5-25 parts of trigone, 5-25 parts of curcuma zedoary, 5-25 parts of sun-dried ginseng, 5-25 parts of Rhizoma Atractylodis Macrocephalae, 5-25 parts of Poria cocos, 1-15 parts of radix glycyrrhizae preparata, when Return 10-30 parts, 5-25 parts of peach kernel, 5-25 parts of turtle shell, 5-25 parts of oyster, 1-15 parts of Rehmannia glutinosa, 5-25 parts of white peony, fritillaria thunbergii 10-30 parts, 5-25 parts of rhizoma pinellinae praeparata, 5-25 parts of dried orange peel, 20-40 parts of oldenlandia diffusa, 5-25 parts of Sculellaria barbata are made.
It is previously described in the drug of malignant tumour early stage, the effective medicinal components are calculated according to composition by weight, by trigone 15 parts, 15 parts of curcuma zedoary, 15 parts of sun-dried ginseng, 15 parts of Rhizoma Atractylodis Macrocephalae, 15 parts of Poria cocos, 10 parts of radix glycyrrhizae preparata, 20 parts of Radix Angelicae Sinensis, 15 parts of peach kernel, turtle shell 15 parts, 15 parts of oyster, 10 parts of Rehmannia glutinosa, 15 parts of white peony, 20 parts of fritillaria thunbergii, 15 parts of rhizoma pinellinae praeparata, 15 parts of dried orange peel, oldenlandia diffusa 30 parts, 15 parts of Sculellaria barbata are made.
It is previously used for the preparation method of the drug of malignant tumour early stage, takes said medicine, with auxiliary material acceptable in drug It is combined, or auxiliary material is not added, conventionally processed, corresponding pharmaceutical preparation is made.
It is previously used in the preparation method of the drug of malignant tumour early stage, the pharmaceutical preparation is oral preparation.
It is previously used in the preparation method of the drug of malignant tumour early stage, the oral preparation is decoction, granule or decocts Paste.
It is previously used in the preparation method of the drug of malignant tumour early stage, the decoction is prepared: weighing in proportion Drug is stated, turtle shell and oyster are smashed, the 2-4 times of water measured is added, be decocted first 30-60min.The water measured again with 2-4 times of addition impregnates Trigone, curcuma zedoary, sun-dried ginseng, Rhizoma Atractylodis Macrocephalae, Poria cocos, radix glycyrrhizae preparata, Radix Angelicae Sinensis, peach kernel, Rehmannia glutinosa, white peony, fritillaria thunbergii after 20-30min, Rhizoma pinellinae praeparata, dried orange peel, oldenlandia diffusa, Sculellaria barbata mixing, are then decocted with moderate heat to boiling with casserole, then decocted with small fire 20-25min filters the dregs of a decoction while hot and retains decocting liquid A, the 2-4 times of water measured is added into the dregs of a decoction, decocts 20-30min, filters while hot The dregs of a decoction retain decocting liquid B, collecting decoction A and decocting liquid B to get the decoction.
It is previously used in the preparation method of the drug of malignant tumour early stage, the granule is prepared: weighing in proportion Said medicine is ground into most coarse powder, soaks in water 20-30min, decocts three times, each 30min, collecting decoction, filtration, filtrate The thick paste that relative density is 1.30~1.35 when being concentrated into 80 DEG C is added the dextrin of the amount of being made 33%, the sucrose of the amount of being made 48%, mixes It is even, particle is made, it is dry to get the granule.
It is previously used in the preparation method of the drug of malignant tumour early stage, the soft extract is prepared: weighing in proportion Said medicine is ground into most coarse powder, soaks in water 20-30min, decocts 3 times, and the water measured for the first time with 12 times decocts 3 hours, the The secondary water measured with 8 times decocts 2 hours, and the water measured for the third time with 6 times decocts 0.5 hour, collecting decoction, and filtration is condensed into 60- Then the honey of medicinal extract amount 50% is added in the medicinal extract for the 1.10-1.15 that relative density is at 65 DEG C in medicinal extract, heating mixes, Relative density is the medicinal extract of 1.2-1.25 to get the soft extract when being concentrated into 60-65 DEG C.
Effective medicinal components of the present invention by trigone, curcuma zedoary, sun-dried ginseng, Rhizoma Atractylodis Macrocephalae, Poria cocos, radix glycyrrhizae preparata, Radix Angelicae Sinensis, peach kernel, turtle shell, Oyster, Rehmannia glutinosa, white peony, fritillaria thunbergii, rhizoma pinellinae praeparata, dried orange peel, oldenlandia diffusa and Sculellaria barbata are made, wherein trigone, are black three The dry tuber of rib section plant rhizoma scirpi Sparganium stoloniferum Buch.-Ham.；Major function breaking blood and promoting the circulation of qi, Clearing stagnation and killing pain；For abdominal mass lump in the abdomen, blood stasis closed, dyspepsia distending pain.Curcuma zedoary, source this product are zingiberaceous plant zedoary Curcuma Phaeocaulis Val., Guangxi zedoary Curcuma Kwangsiensis S. G.Lee et C. F. Liang or Wen Yu The dry rhizome of golden Curcuma wenyujin Y.H. Chen et C. Ling；Major function promoting the circulation of qi blood-breaking, clearing stagnation and killing pain. For Dan lump in the abdomen lump in the abdomen, blood stasis closed, dyspepsia distending pain.Sun-dried ginseng, this product are Araliaceae ginseng Panax ginseng C. A. Mey. dry root；Major function replenish vital energy, restore pulse, and strengthen and remove vital energy, reinforces the spleen to benefit the lung, and promotes the production of body fluid, and calms the nerves；It to be taken off for physically weak, limb cold arteries and veins Micro-, spleen eating less, the deficiency syndrome of the lung is breathed with cough, injury thirst, Heat Diabetes, and prolonged illness void is thin, insomnia of palpitating with fear, impotence palace cold；Heart failure, the heart Originality shock.Rhizoma Atractylodis Macrocephalae, Classification system Atractylodes macrocephala；Belong to composite family, [WTBX perennial herb is planted Object；With strengthening the spleen and replenishing qi, the effect of eliminate dampness and have diuretic effect, hidroschesis, miscarriage prevention, it to be used for spleen eating less, abdominal distention diarrhea, phlegm retention anti-dazzle nervous, oedema, Spontaneous perspiration, threatened abortion.Poria cocos is the dry sclerotia of polyporaceae fungus Poria cocos (Schw.) Wolf；Advantageous water Excreting dampness, invigorating the spleen, calming heart effect；For edema and little urine, phlegm retention anti-dazzle nervous, spleen eating less, loose stool diarrhea, confused and worried, insomnia of palpitating with fear. Radix glycyrrhizae preparata (RADIX GLYCYRRHIZAE PREPARATA), is leguminous plant, and radix glycyrrhizae preparata is the Radix Glycyrrhizae baked with honey；Have in The effect of emergency, moistening lung, removing toxic substances, coordinating the drug actions of a prescription；For weakness of the spleen and the stomach, fatigue and weakness, severe palpilation, knotted pulse, detachable son poison. Radix Angelicae Sinensis is the dry root of umbelliferae angelica Angelica sinensis (Oliv.) Diels.There is replenishing and activating blood, menstruation regulating stops Bitterly, the effect of relax bowel and defecation；For blood deficiency chlorosis, dizziness palpitaition, irregular menstruation, amenorrhea and algomenorrhea, asthenia cold abdominalgia, rheumatic arthralgia, Injury from falling down, ulcer sores, dry constipation of intestines.Prepared RADIX ANGELICAE SINENSIS with yellow rice wine blood circulation.For amenorrhea and algomenorrhea, rheumatic arthralgia, injury from falling down.Peach Benevolence is rosaceous plant peach Prunus persica (L.) Batsch or mountain peach Prunus davidiana (Carr.) Franch. dry mature seed；Major function promoting blood circulation, relax bowel and defecation.For menostasis, dysmenorrhea , wei lump in the abdomen lump in the abdomen falls and flutters damage Wound, dry constipation of intestines.Turtle shell is the carapace of cyprinidae Trionyx sinensis Wiegmann；Major function enriching yin is latent Sun, resolving hard lump are brought down a fever except steaming；For fever due to yin deficiency, the hot hectic fever due to yin of labor, endogenous deficient wind, menostasis , wei lump in the abdomen, chronic malaria malaria with abdominal mass.Oyster, For the shell of Ostreidae animal Crassostrea rivularis, long oyster or ostrea talienwhanensis Crosse etc.；Major function are as follows: hold back yin, checking exuberance of yang, hidroschesis is puckery Essence, resolving sputum, softening hard masses；Control frightened epilepsy, dizziness, spontaneous perspiration, night sweat, spermatorrhea, stranguria with turbid discharge, metrorrhagia and metrostaxis, leukorrhagia, scrofula, goiter；It is lost for palpitating with fear Band, stomachache and sour regurgitation are collapsed in dormancy, dizziness and tinnitus, tuberculous lymphadenitis, lump in the abdomen lump in the abdomen, spontaneous sweating, spermatorrhea.Rehmannia glutinosa, for scrophulariaceae Yellow or bosom celebrating glutinous rehmannia rhizome, processed steaming are shone.Major function are as follows: enriching yin is enriched blood.It is few to control deficiency of Yin blood, waist knee flaccidity, labor It coughs hectic fever due to yin, spermatorrhea, metrorrhagia and metrostaxis, irregular menstruation is quenched one's thirst, number of urinating, deaf, blurred vision.White peony is ranunculaceae plant Chinese herbaceous peony Paeonia The dry root of tacti lora Pall.；With nourishing blood for regulating menstruation, the effect of astringing YIN to stop sweating, soft liver analgesic, suppressing liver-YANG；For blood Empty sallow, irregular menstruation, spontaneous perspiration, night sweat, hypochondriac pain, abdominal pain, four limbs contraction pain, headache and dizziness.Fritillaria thunbergii is liliaceous plant bulb of thunberg fritillary The dry bulb of female Fritillaria thunbergii Miq.；Major function heat-clearing dissipating bind, preventing phlegm from forming and stopping coughing are violated for wind-heat Lung, phlegm-fire cough, pulmonary abscess, acute mastitis, scrofula, sore.Rhizoma pinellinae praeparata is aroid tuber of pinellia Pinellia ternata (Thunb.) dry tuber of Breit.；Major function is eliminating dampness and eliminating phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass；For abundant expectoration cough and asthma, phlegm Drink feel dizzy and heart palpitations, anemophlegmatic vertigo, phlegm and headache, vomiting gastric disorder causing nausea, chest gastral cavity ruffian, globus hysteriocus；It is raw to use controlling outward carbuncle swells subcutaneous nodule.Dried orange peel is rue Savoury herb tangerine Citrus reticulata Blanco and its dry mature skin of variety；Major function qi-regulating is strong Spleen is eliminating dampness and eliminating phlegm；For chest gastral cavity turgor, deficiency of food is vomited and diarrhoea, coughing with a lot of sputum.Oldenlandia diffusa is Rubiaceae plants of Hedyotis white flower The herb of HERBA HEDYOTIS DIFFUSAE Hedyotis diffusa Willd. [Oldenlandia diffusa (Willd.) Roxb.]；Have clear Thermal detoxification, effect that dampness removing is treating stranguria；For dyspnea and cough due to lung-heat, abscess of throat, acute appendicitis, furuncle sore, venomous snake bite, puckery pain of heat gonorrhea, Oedema, dysentery, enteritis, jaundice with damp-heat pathogen, cancerous swelling.Sculellaria barbata is Lamiaceae plant Sculellaria barbata Scutellaria barbata Don The drying herb of [S. rivularis Wall]；Major function is clearing heat and detoxicating, stagnation resolvation diuresis.For furuncle swelling toxin, throat is swollen Bitterly, venomous snake bite, the pain of injury caused by falling and tumbling, oedema, jaundice.
Fang Xie: Fang Zhongzhi " gas " with sun-dried ginseng, Rhizoma Atractylodis Macrocephalae, Poria cocos, radix glycyrrhizae preparata (Sijunzi Tang) help lung spleen gas, guarantee " official of storehouse official report " can continually supply substance metaplasia energy.With trigone, curcuma zedoary promoting the circulation of qi relieving stagnant Qi, the two and the energy blood-breaking row stasis of blood. It controls " blood " to enrich blood with Radix Angelicae Sinensis, Rehmannia glutinosa, white peony blood-nourishing, be disappeared sign with peach kernel, turtle shell, oyster broken stasis of blood." water " is controlled with fritillaria thunbergii, method The tuber of pinellia, dried orange peel reducing phlegm and resolving masses.Add oldenlandia diffusa, Sculellaria barbata clearing heat and detoxicating, it is evil with the heat evil in clear sharp qi and blood water, poison, altogether at Drug of the invention.Have effects that stronger removing summer-heat heat toxin, is suitable for malignant tumour early stage.Function Heibei provincial opera yin yin, Heibei provincial opera qi and blood, broken stasis of blood dissipate stagnant, clearing heat and detoxicating.
Compared with prior art, the invention has the characteristics that:
Under the major premise of Yin-yang theory of TCM, based on seedling cures three opinions, qi and blood water is discussed.By adjusting gas, blood, water yin Rising tone weighing apparatus reaches adjustment substance, energy, between structure three and the respectively dynamic equilibrium of internal yin-yang.Drug of the invention by Promoting the circulation of qi Qi-tonifying drug, promoting blood circulation, which disappear, levies medicine, reducing phlegm and resolving masses medicine and heat-clearing and detoxifying drug composition, takes traditional Chinese medicine theory and seedling medicine theoretical Essence mutually merge, penetrate through to improve curative effect of the traditional medicine in treating malignant tumor.Heat-clearing and detoxifying drug oldenlandia diffusa And Sculellaria barbata, discovery table has the effects that inhibit tumor proliferation, apoptosis-induced in pharmacological research early period.Drug of the invention exists In clinical application, inhibition malignant progression is had received, improves life in patients, extend the preferable curative effects such as life span. Based on " qi and blood water " theory of seedling medicine, drug of the invention is created in line with " controlling gas ", " harnessing the river ", " controlling blood " principle, it is intended to logical Cross promoting the circulation of qi tonifying Qi, promoting blood circulation disappear sign, reducing phlegm and resolving masses, clearing heat and detoxicating reach blocking malignant progression.Below will using TCM, OMIM, It is pernicious swollen to illustrate drugs block of the invention by the method for network pharmacology for the databases such as GeneCards, STRING, KEGG The modern pharmacology basis of tumour development and mechanism.
It is found first by analysis, " controlling gas " monarch drug in a prescription ginseng, " harnessing the river " the monarch drug in a prescription tuber of pinellia, " controlling blood " monarch drug in a prescription trigone (referred to as " ginseng Summer rib ") effective component of three can pass through CASP3, CASP8, CASP9, BCL2 etc. and adjust nuclear receptor activities and transcription factor Activity participates in the Signal Transduction Pathways of Apoptosis, mediates malignant cell apoptosis, blocks malignant progression.Tumour-ginseng summer rib- Ingredient-target spot regulated and control network is as shown in Figure 1.Join summer rib effective component can by target gene BCL2, CASP9, CASP3, CASP8, CHEK1, CCNB1 etc. participate in P53 signal transduction pathway, and (IL-17 signal is logical for DNA plerosis damage, oxidativestress damage Road, TNF signal path etc.), inhibit oncogene activation or promote cancer cell removing, apoptosis etc., malignant tumour is effectively blocked to occur, Develop (Fig. 2, Fig. 3).Ginseng summer rib can also act on prostate cancer, colorectal cancer, Small Cell Lung Cancer and non-small by effective component Cell lung cancer, breast cancer, carcinoma of endometrium, cancer of pancreas, cancerous tissue PD-l expression and the checkpoint PD-1, hepatocellular carcinoma, cancer gallbladder The coherent signals conduction path such as alkali metabolism, cancer MicroRNAs, clear-cell carcinoma, chronic myelogenous leukemia, to the above malignant tumour Have a certain impact.So from traditional seedling medicine theory and traditional Chinese medical theory, clinical practice and network pharmacology mechanism of action Analysis, which effectively illustrates ginseng summer rib, has the function of that malignant tumour is inhibited to occur, develop.
Oldenlandia diffusa and Sculellaria barbata (hereinafter referred to as white lotus) are inhibited to the modern times of tumor proliferation, apoptosis-induced effect below Pharmacological Mechanism is analyzed as follows:
It completes to analyze using databases such as TCM, OMIM, GeneCards, STRING, KEGG.It is screened in the ingredient of white lotus Oral administration biaavailability is greater than 30% out, and quasi-medicated property is greater than 0.18 ingredient, then finds out the action target spot of these ingredients.From disease Target spot relevant to tumour is found out in data, and intersection target spot (Fig. 4) between the two is taken by molecular docking.As can be seen that white The effective component target gene and tumor invasion related target gene of lotus have more intersection.Tumour-white lotus-ingredient-target spot regulation Network is as shown in Figure 5.Intersection target gene interactions between protein network is as shown in Figure 6.Function and access enrichment are carried out to intersection target spot Discovery (as shown in Figure 7, Figure 8) is analyzed, white lotus can participate in p53 signal by 11 genes such as BCL2, CASP9, CASP3, CASP8 Access can monitor malignant change of cell in real time, inhibit malignant cell to occur, development, promote apoptosis (Fig. 9).Wherein BCL2, CASP8 etc. can inhibit its malignancy by the promotion malignant tumour functional protein hydrolysis in conjunction with ubiquitin-like protein ligase, Promote malignant cell death.
White lotus can be believed by the direct apoptosis involvement correlation of 13 genes such as BCL2, CASP9, CASP3, CASP8, RELA, FOS Number access, directly facilitates malignant tumor cell apoptosis (Figure 10).Wherein the genes such as RELA, FOS can pass through specific RNA polymerase II, proximal promoter sequence specific DNA influences apoptosis correlation DNA combination transcriptional activation activity, mediate tumor cell apoptosis.
White lotus can directly participate in cell ageing by 11 genes such as RELA, CCND1, RB1, IL6, RAF1, MYC, CCNB1 Related pathways directly facilitate malignant cell aging, inhibit malignant cell proliferation when playing indirectly, generate, transfer (figure 11).
White lotus can participate in EGF-R ELISA junket ammonia by 9 genes such as BCL2, PRKCA, EGFR, VEGFA, IL6 (Figure 12) is adjusted to malignant cell differentiation, growth, proliferation, transfer in acid kinase related pathways.Wherein BCL2, EGFR Deng can pass through in conjunction with ubiquitin-like protein ligase promote malignant tumour apoptosis.
White lotus can participate in PI3K-Akt signal by 16 genes such as BCL2, CASP9, PRKCA, RELA, EGFR, VEGFA Access acts synergistically with p53 signal path, influences cell cycle, the interference proliferation of malignant cell, malignant cell is promoted to wither Die (Figure 13).
In conclusion drug of the invention has promoting the circulation of qi tonifying Qi, sign, reducing phlegm and resolving masses, the antipyretic and antidote functions of disappearing of invigorating blood circulation, it can Inhibit malignant cell growth, proliferation, transfer, promotes apoptosis；It is practical for malignant tumour early treatment.
Detailed description of the invention
Fig. 1 is tumour-ginseng summer rib-ingredient-target spot regulated and control network schematic diagram；
Fig. 2 is tumour-ginseng summer rib gene function enrichment analysis schematic diagram；
Fig. 3 is tumour-ginseng summer rib gene pathway enrichment analysis schematic diagram；
Fig. 4 is tumour-white lotus intersection target spot schematic diagram；
Fig. 5 is tumour-white lotus-ingredient-target spot regulated and control network schematic diagram；
Fig. 6 is tumour-white lotus interactions between protein network；
Fig. 7 is tumour-white lotus gene function enrichment analysis chart；
Fig. 8 is tumour-white lotus gene pathway enrichment analysis chart；
Fig. 9 is P53 signal transduction pathway figure；
Figure 10 is apoptosis associated signal paths figure；
Figure 11 is cell ageing associated signal paths figure；
Figure 12 is epidermal growth factor recipient tyrosine kinase related pathways；
Figure 13 is PI3K-Akt signal path.
Specific embodiment
Below with reference to embodiment, the present invention is further illustrated, but is not intended as the foundation limited the present invention.
Embodiment 1: a kind of drug for malignant tumour early stage, effective medicinal components are by trigone 15g, curcuma zedoary 15g, sun-dried Join 15g, Rhizoma Atractylodis Macrocephalae 15g, Poria cocos 15g, radix glycyrrhizae preparata 10g, Radix Angelicae Sinensis 20g, peach kernel 15g, turtle shell 15g, oyster 15g, Rehmannia glutinosa 10g, white Chinese herbaceous peony 15g, fritillaria thunbergii 20g, rhizoma pinellinae praeparata 15g, dried orange peel 15g, 30 parts of oldenlandia diffusa, 15 parts of Sculellaria barbata are made.
The drug is decoction, which is prepared: weighing said medicine in proportion, turtle shell and oyster are smashed, add Enter the 2-4 times of water measured, be decocted first 30-60min.Again with the trigone after the 2-4 times of water measured impregnates 20-30min, curcuma zedoary, sun-dried is added Ginseng, Rhizoma Atractylodis Macrocephalae, Poria cocos, radix glycyrrhizae preparata, Radix Angelicae Sinensis, peach kernel, Rehmannia glutinosa, white peony, fritillaria thunbergii, rhizoma pinellinae praeparata, dried orange peel, oldenlandia diffusa, half Branch lotus mixing, is then decocted with moderate heat to boiling with casserole, then decoct 20-25min with small fire, is filtered dregs of a decoction reservation while hot and is decocted The 2-4 times of water measured is added into the dregs of a decoction by liquid A, decocts 20-30min, filters dregs of a decoction reservation decocting liquid B, collecting decoction A while hot and decocts Liquid B is to get the decoction.
Usage and dosage: oral, 200ml/ times, 3 times/day, half an hour warmly takes before meals.
Embodiment 2: a kind of drug for malignant pleural mesothelioma malignant tumour early stage, effective medicinal components are by trigone 50g, curcuma zedoary 50g, sun-dried ginseng 50g, Rhizoma Atractylodis Macrocephalae 50g, Poria cocos 50g, radix glycyrrhizae preparata 10g, Radix Angelicae Sinensis 100g, peach kernel 50g, turtle shell 50g, oyster 50g, Rehmannia glutinosa 11g, white peony 52g, fritillaria thunbergii 100g, rhizoma pinellinae praeparata 50g, dried orange peel 50g, 200g parts of oldenlandia diffusa, Sculellaria barbata 50g is made.
The drug is granule, which is prepared: weighing said medicine in proportion, is ground into most coarse powder, adds Water impregnates 20min, decocts three times, and the water measured every time with 8 times decocts 30min, merges decocting liquid three times, filters, and filtrate is concentrated into The thick paste that relative density is 1.34 at 80 DEG C is added the dextrin of the amount of being made 33%, the sucrose of the amount of being made 48%, mixes, particle is made, Drying is to get the granule.
Usage and dosage: half an hour warm water is taken after mixing it with water before meals, 2-3 times daily, 2-3 bags each.
Embodiment 3: a kind of drug for malignant tumour early stage, effective medicinal components are by trigone 25g, curcuma zedoary 25g, sun-dried Join 25g, Rhizoma Atractylodis Macrocephalae 25g, Poria cocos 25g, radix glycyrrhizae preparata 15g, Radix Angelicae Sinensis 30g, peach kernel 25g, turtle shell 25g, oyster 25g, Rehmannia glutinosa 15g, white Chinese herbaceous peony 25g, fritillaria thunbergii 30g, rhizoma pinellinae praeparata 25g, dried orange peel 25g, oldenlandia diffusa 40g, Sculellaria barbata 25g are made.
The drug is soft extract, which is prepared: weighing said medicine in proportion, is ground into most thick Powder soaks in water 20-30min, decocts 3 times, and the water measured for the first time with 12 times decocts 3 hours, and second of the water measured with 8 times decocts 2 hours, the water measured for the third time with 6 times decocted 0.5 hour, collecting decoction, filtration, relative density when being condensed into 60-65 DEG C The medicinal extract of 1.10-1.15, is then added the honey of medicinal extract amount 50% in medicinal extract, and heating is mixed, is concentrated into opposite at 60-65 DEG C Density is the medicinal extract of 1.2-1.25 to get the soft extract.
Usage and dosage: half an hour warm water is taken after mixing it with water before meals, 2-3 times daily, each 10-30g.

Claims (8)

1. a kind of drug for malignant tumour early stage, it is characterised in that: effective medicinal components are calculated according to composition by weight, by trigone 5-25 parts, 5-25 parts of curcuma zedoary, 5-25 parts of sun-dried ginseng, 5-25 parts of Rhizoma Atractylodis Macrocephalae, 5-25 parts of Poria cocos, 1-15 parts of radix glycyrrhizae preparata, Radix Angelicae Sinensis 10-30 Part, 5-25 parts of peach kernel, 5-25 parts of turtle shell, 5-25 parts of oyster, 1-15 parts of Rehmannia glutinosa, 5-25 parts of white peony, 10-30 parts of fritillaria thunbergii, 5-25 parts of rhizoma pinellinae praeparata, 5-25 parts of dried orange peel, 20-40 parts of oldenlandia diffusa, 5-25 parts of Sculellaria barbata are made.
2. the drug according to claim 1 for malignant tumour early stage, it is characterised in that: the effective medicinal components shine Composition by weight calculates, by 15 parts of trigone, 15 parts of curcuma zedoary, 15 parts of sun-dried ginseng, 15 parts of Rhizoma Atractylodis Macrocephalae, 15 parts of Poria cocos, 10 parts of radix glycyrrhizae preparata, Radix Angelicae Sinensis 20 parts, 15 parts of peach kernel, 15 parts of turtle shell, 15 parts of oyster, 10 parts of Rehmannia glutinosa, 15 parts of white peony, 20 parts of fritillaria thunbergii, 15 parts of rhizoma pinellinae praeparata, 15 parts of dried orange peel, 30 parts of oldenlandia diffusa, 15 parts of Sculellaria barbata are made.
3. a kind of preparation method for the drug of malignant tumour early stage as claimed in claim 1 or 2, it is characterised in that: take Drug is stated, is combined with auxiliary material acceptable in drug, or auxiliary material is not added, is conventionally processed, is made corresponding Pharmaceutical preparation.
4. the preparation method for the drug of malignant tumour early stage according to claim 3, it is characterised in that: the drug system Agent is oral preparation.
5. the preparation method for the drug of malignant tumour early stage according to claim 4, it is characterised in that: the oral system Agent is decoction, granule or soft extract.
6. according to claim 5 for malignant tumour early stage drug preparation method, it is characterised in that: the decoction this Sample preparation: weighing said medicine in proportion, turtle shell and oyster smashed, and the 2-4 times of water measured is added, be decocted first 30-60min.Again with The trigone after the 2-4 times of water measured impregnates 20-30min, curcuma zedoary, sun-dried ginseng, Rhizoma Atractylodis Macrocephalae, Poria cocos, radix glycyrrhizae preparata, Radix Angelicae Sinensis, peach kernel, ripe is added Glutinous rehmannia, white peony, fritillaria thunbergii, rhizoma pinellinae praeparata, dried orange peel, oldenlandia diffusa, Sculellaria barbata mixing, are then decocted with moderate heat to boiling with casserole After rising, then with small fire decoction 20-25min, the dregs of a decoction are filtered while hot and retain decocting liquid A, the 2-4 times of water measured is added into the dregs of a decoction, decocts 20-30min filters the dregs of a decoction while hot and retains decocting liquid B, collecting decoction A and decocting liquid B to get the decoction.
7. the preparation method for the drug of malignant tumour early stage according to claim 5, it is characterised in that: the granule It is prepared: weighing said medicine in proportion, be ground into most coarse powder, soak in water 20-30min, decoct three times, each 30min, Collecting decoction, filtration, the thick paste that relative density is 1.30~1.35 when filtrate is concentrated into 80 DEG C, the dextrin of the addition amount of being made 33%, The sucrose of the amount of being made 48% mixes, and particle is made, dry to get the granule.
8. the preparation method for the drug of malignant tumour early stage according to claim 5, it is characterised in that: the soft extract It is prepared: weighing said medicine in proportion, be ground into most coarse powder, soak in water 20-30min, decoct 3 times, for the first time with 12 The water of amount decocts 3 hours again, and for the second time with the water decoction of 8 times of amounts 2 hours, the water measured for the third time with 6 times is decocted 0.5 hour, conjunction And then medicinal extract amount is added in decocting liquid, filtration, the medicinal extract for the 1.10-1.15 that relative density is when being condensed into 60-65 DEG C in medicinal extract 50% honey, heating mix, and relative density is the medicinal extract of 1.2-1.25 to get the soft extract when being concentrated into 60-65 DEG C.
CN201910792308.7A 2019-08-26 2019-08-26 A kind of drug and preparation method thereof for malignant tumour early stage Withdrawn CN110368475A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201910792308.7A CN110368475A (en) 2019-08-26 2019-08-26 A kind of drug and preparation method thereof for malignant tumour early stage

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201910792308.7A CN110368475A (en) 2019-08-26 2019-08-26 A kind of drug and preparation method thereof for malignant tumour early stage

Publications (1)

Publication Number Publication Date
CN110368475A true CN110368475A (en) 2019-10-25

Family

ID=68260742

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201910792308.7A Withdrawn CN110368475A (en) 2019-08-26 2019-08-26 A kind of drug and preparation method thereof for malignant tumour early stage

Country Status (1)

Country Link
CN (1) CN110368475A (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110898154A (en) * 2019-12-03 2020-03-24 虞泽君 Formula for treating colon malignant tumor

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110898154A (en) * 2019-12-03 2020-03-24 虞泽君 Formula for treating colon malignant tumor

Similar Documents

Publication Publication Date Title
CN107303383A (en) A kind of Chinese medicine composition and its derivative and product to a variety of symptoms with effect
CN102319407B (en) Traditional Chinese medicine for treating gastroptosis and extraction method thereof
CN102319408B (en) Chinese medicine for strengthening spleen, eliminating dampness and treating gastroptosis and extraction method thereof
CN102784363A (en) Traditional Chinese medicine composition for treating pancreatic cancer and preparation method thereof
CN104338043B (en) A kind of medicine for improving immunity and preparation method thereof
CN102526498B (en) Chinese medicine for eliminating toxic and side effects after nasopharyngeal carcinoma radiotherapy and preparation method and administration way thereof
CN103550506B (en) A kind of in radiotherapy with the use of Chinese medicine composition
CN103301267B (en) Traditional Chinese medicine composition for treating hypertension and/or atherosclerosis and application thereof
CN112717081B (en) Blood-activating face-beautifying cream formula and application thereof
CN104436009A (en) Medicine for treating liver cancer
CN104225502A (en) Obstetrics and gynecology drug for treating endocrine dyscrasia and preparation method thereof
CN106728694A (en) A kind of tumor post-operation patients ' recovery Chinese medicine preparation and preparation method thereof
CN110368475A (en) A kind of drug and preparation method thereof for malignant tumour early stage
CN103285343B (en) Medicine for treating liver cancer and preparation method thereof
CN103386024A (en) Traditional Chinese medicine preparation for treating pancreas cancer and preparation method thereof
CN102526484B (en) Medicinal composition for decreasing blood sugar
CN110420304A (en) A kind of drug and preparation method thereof for the benign tumors sexual stage
CN110393784A (en) A kind of drug and preparation method thereof for malignant tumour
CN103705731B (en) A kind of Chinese medicine composition for the treatment of chronic alcoholic toxic liver disease
CN103656197B (en) The Chinese medicine composition of kidney tonifying and enriching blood and preparation method
CN105327181A (en) Medicine composition for treating diabetes
CN105616874A (en) Liver cancer treatment pharmaceutical composition and preparation method thereof
CN105250588A (en) Chinese herbal preparation for treating kidney failure and preparation method of Chinese herbal preparation
CN104840773A (en) Traditional Chinese medicine composition for treating vertebral artery type cervical spondylopathy and method for preparing same
CN110393783A (en) A kind of drug and preparation method thereof for malignant tumour advanced stage

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
WW01 Invention patent application withdrawn after publication

Application publication date: 20191025

WW01 Invention patent application withdrawn after publication