CN110420304A - A kind of drug and preparation method thereof for the benign tumors sexual stage - Google Patents
A kind of drug and preparation method thereof for the benign tumors sexual stage Download PDFInfo
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Abstract
The drug and preparation method thereof that the invention discloses a kind of for the benign tumors sexual stage, effective medicinal components are made of trigone, curcuma zedoary, sun-dried ginseng, Rhizoma Atractylodis Macrocephalae, Poria cocos, radix glycyrrhizae preparata, Radix Angelicae Sinensis, peach kernel, turtle shell, oyster, Rehmannia glutinosa, white peony, fritillaria thunbergii, rhizoma pinellinae praeparata and dried orange peel.Medicine property of medicine of the invention is gentle, is suitable for heat symptom-complex, cold card；There is the negative yin of Heibei provincial opera, Heibei provincial opera qi and blood, broken stasis of blood to dissipate the benefits of stagnant；It is practical for the treatment of benign tumors sexual stage, by adjusting smooth qi and blood, promote lump to dissipate, blocking its development in early days is malignant tumour.
Description
Technical field
The drug and preparation method thereof that the present invention relates to a kind of for the benign tumors sexual stage, belongs to the field of drug technology.
Background technique
Cancer Mortality increases year by year in recent years.If liver cancer the whole world disease incidence constantly rise, at present housing I
The tumor lethal cause of disease of the 4th of state's malignant tumour and third position, seriously threatens the life and health of our people.Cervical carcinoma occupies
In female malignant incidence second.According to WHO data, there are new cases 530,000 in the whole world every year, and about 250,000 women are because dying of illness
It dies, wherein developing country accounts for 80%.Cases of cervical cancer about 140,000, death about 3.7 ten thousand are increased newly every year in China.
Malignant tumour is China human mortality main reason dead before average life span.It is disliked from the China 2000-2011
From the point of view of property tumour related data, disease incidence and the death rate can be significantly reduced for the primary prevention of risk factor/cause of disease, but face
Bed treatment is to reduction malignant tumour somatic death rate but without obvious contribution function.
Though modern medicine has many researchs in relation to tumour, therapeutic effect is still undesirable.Huangdi's Internal Classics cloud: " upper doctor
It preventives treatment of disease, middle treatment is intended to disease, lower doctor's treating the disease affected ".Therefore be badly in need of finding a kind of compound for treating the benign tumors sexual stage from traditional medicine,
Early stage blocks the development of tumour, embodies the "prevention first" of early prevention, early treatment.The ordinary circumstance of benign tumour patient compared with
It is good, or even without special discomfort.The clear mass of tissue local visible borders, degree of excursion is good, closes on lymph node without enlargement.Ultrasonic examination
Lump and periphery blood flow signal are few.Benign tumour also often blocks local gas, blood, causes physiological dysfunction.Tumour is in benign
When the stage, as long as timely and effective intervention may prevent it from developing into malignant tumour, greatly reduce treatment difficulty.
China not only possesses pools of traditional Chinese medicine, also possesses many national medicine treasure-houses, and seedling medicine is exactly one of them.According to examining
Card, seedling medicine have more than 2,000 years history so far, huge contribution are made that in terms of guarding people's health.Seedling cures important reason
By one of " three opinion " --- think that human body is by energy, substance, structure composition.Energy refer to inborn creature can and it is posteriori
Physiology energy；Substance refers to slurries, blood, anima etc.；Structure refers to nine big frame groups i.e. brain frame, stature, cave frame etc.." gas (weather,
Popularity, ground vapour), blood, water (true water, waste water) opinion " be also its Academic Core thought.Seedling doctor thinks: energy, substance, structure and gas,
Blood, water balance not normal disease i.e. " disorderly no not at disease " will occur.This has certain directive function to the interpretation of the cause, onset and process of an illness understanding of tumour,
By adjusting energy, supplementation material, improve structure, the balance for adjusting qi and blood water can control tumour to a certain extent.
Traditional medicine thinks tumour Xiang Dang Yu Disorder lump in the abdomen, accumulation, malignant sore (tumor) etc., it is believed that stagnates with poly-, the malicious heresy of qi and blood knot close
Cut phase is closed.Traditional Chinese medical science great master Professor Zhou Zhongying proposes " cancer poison " theory according to more than 60 years clinical experience, and promotion is clearing heat and detoxicating and with poison
Attack the method for " toxic removing " of poison.
Therefore, based on yin-yang theory, in conjunction with the correlation theory of seedling medicine, this medicinal peace is invented, there is Heibei provincial opera
Negative yin, Heibei provincial opera qi and blood, broken stasis of blood dissipate the benefits of stagnant, and the drug for tumour early stage has great importance.
Summary of the invention
The drug and preparation method thereof that the object of the present invention is to provide a kind of for the benign tumors sexual stage.Of the invention
Drug is gentle, and there is the negative yin of Heibei provincial opera, Heibei provincial opera qi and blood, broken stasis of blood to dissipate the benefits of stagnant, and it is pernicious swollen for capable of blocking benign tumour development in early days
Tumor.
Technical solution of the present invention: a kind of drug for the benign tumors sexual stage, effective medicinal components shine composition by weight meter
Calculate, by 5-25 parts of trigone, 5-25 parts of curcuma zedoary, 5-25 parts of sun-dried ginseng, 5-25 parts of Rhizoma Atractylodis Macrocephalae, 5-25 parts of Poria cocos, 1-15 parts of radix glycyrrhizae preparata, when
Return 10-30 parts, 5-25 parts of peach kernel, 5-25 parts of turtle shell, 5-25 parts of oyster, 1-15 parts of Rehmannia glutinosa, 5-25 parts of white peony, fritillaria thunbergii
10-30 parts, 5-25 parts of rhizoma pinellinae praeparata, 5-25 parts of dried orange peel be made.
It is previously described in the drug of benign tumors sexual stage, the effective medicinal components are calculated according to composition by weight, by trigone
15 parts, 15 parts of curcuma zedoary, 15 parts of sun-dried ginseng, 15 parts of Rhizoma Atractylodis Macrocephalae, 15 parts of Poria cocos, 10 parts of radix glycyrrhizae preparata, 20 parts of Radix Angelicae Sinensis, 15 parts of peach kernel, turtle shell
15 parts, 15 parts of oyster, 10 parts of Rehmannia glutinosa, 15 parts of white peony, 20 parts of fritillaria thunbergii, 15 parts of rhizoma pinellinae praeparata, 15 parts of dried orange peel be made.
It is previously used for the preparation method of the drug of benign tumors sexual stage, takes said medicine, with auxiliary material acceptable in drug
It is combined, or auxiliary material is not added, conventionally processed, corresponding pharmaceutical preparation is made.
It is previously used in the preparation method of the drug of benign tumors sexual stage, the pharmaceutical preparation is oral preparation.
It is previously used in the preparation method of the drug of benign tumors sexual stage, the oral preparation is decoction, granule or decocts
Paste.
It is previously used in the preparation method of the drug of benign tumors sexual stage, the decoction is prepared: weighing in proportion
Drug is stated, turtle shell and oyster are smashed, the 2-4 times of water measured is added, be decocted first 30-60min.The water measured again with 2-4 times of addition impregnates
Trigone, curcuma zedoary, sun-dried ginseng, Rhizoma Atractylodis Macrocephalae, Poria cocos, radix glycyrrhizae preparata, Radix Angelicae Sinensis, peach kernel, Rehmannia glutinosa, white peony, fritillaria thunbergii after 20-30min,
Rhizoma pinellinae praeparata and dried orange peel mixing, are then decocted to boiling, then decoct 20-25min with small fire with moderate heat with casserole, filter medicine while hot
Slag retains decocting liquid A, and the 2-4 times of water measured is added into the dregs of a decoction, decocts 20-30min, filters the dregs of a decoction while hot and retains decocting liquid B, merges and decoct
Liquid A and decocting liquid B are to get the decoction.
It is previously used in the preparation method of the drug of benign tumors sexual stage, the granule is prepared: weighing in proportion
Said medicine is ground into most coarse powder, soaks in water 20-30min, decocts three times, each 30min, collecting decoction, filtration, filtrate
The dextrin of the amount of being made 33%, the sucrose of the amount of being made 48% is added in the thick paste that relative density is 1.30~1.35 when being concentrated into 80 DEG C,
It mixes, particle is made, it is dry to get the granule.
It is previously used in the preparation method of the drug of benign tumors sexual stage, the soft extract is prepared: weighing in proportion
Said medicine is ground into most coarse powder, soaks in water 20-30min, decocts 3 times, and the water measured for the first time with 12 times decocts 3 hours, the
The secondary water measured with 8 times decocts 2 hours, and the water measured for the third time with 6 times decocts 0.5 hour, collecting decoction, and filtration is condensed into 60-
Then the honey of medicinal extract amount 50% is added in the medicinal extract for the 1.10-1.15 that relative density is at 65 DEG C in medicinal extract, heating mixes,
Relative density is the medicinal extract of 1.2-1.25 to get the soft extract when being concentrated into 60-65 DEG C.
Effective medicinal components of the present invention by trigone, curcuma zedoary, sun-dried ginseng, Rhizoma Atractylodis Macrocephalae, Poria cocos, radix glycyrrhizae preparata, Radix Angelicae Sinensis, peach kernel, turtle shell,
Oyster, Rehmannia glutinosa, white peony, fritillaria thunbergii, rhizoma pinellinae praeparata and dried orange peel are made, wherein trigone, are Sparganiaceae plant rhizoma scirpi
The dry tuber of Sparganium stoloniferum Buch.-Ham.；Major function breaking blood and promoting the circulation of qi, clearing stagnation and killing pain；For disease
Lump in the abdomen lump in the abdomen, blood stasis closed, dyspepsia distending pain.Curcuma zedoary, source this product are zingiberaceous plant zedoary Curcuma phaeocaulis
Val., Guangxi zedoary Curcuma Kwangsiensis S.G.Lee et C.F.Liang or RADIX CURCUMAE Curcuma
The dry rhizome of wenyujin Y.H.Chen et C.Ling；Major function promoting the circulation of qi blood-breaking, clearing stagnation and killing pain.For Dan lump in the abdomen lump in the abdomen,
Blood stasis closed, dyspepsia distending pain.Sun-dried ginseng, this product are the dry root of Araliaceae ginseng Panax ginseng C.A.Mey.；
Major function replenish vital energy, restore pulse, and strengthen and remove vital energy, reinforces the spleen to benefit the lung, and promotes the production of body fluid, and calms the nerves；It to be taken off for physically weak, cold weak pulse of limb, spleen eating less,
The deficiency syndrome of the lung is breathed with cough, injury thirst, Heat Diabetes, and prolonged illness void is thin, insomnia of palpitating with fear, impotence palace cold；Heart failure, cardiogenic shock.It is white
Art, Classification system Atractylodes macrocephala；Belong to composite family, [WTBX herbaceos perennial；With invigorating the spleen benefit
The effect of gas, eliminate dampness and have diuretic effect, hidroschesis, miscarriage prevention, is used for spleen eating less, and abdominal distention diarrhea, phlegm retention anti-dazzle nervous, oedema, spontaneous perspiration, movement of the foetus is not
Peace.Poria cocos is the dry sclerotia of polyporaceae fungus Poria cocos (Schw.) Wolf；There is a clearing damp and promoting diuresis, invigorating the spleen, rather
Cardiac performance；For edema and little urine, phlegm retention anti-dazzle nervous, spleen eating less, loose stool diarrhea, confused and worried, insomnia of palpitating with fear.Radix glycyrrhizae preparata (RADIX
GLYCYRRHIZAE PREPARATA), it is leguminous plant, radix glycyrrhizae preparata is the Radix Glycyrrhizae baked with honey；Have and middle emergency, moistening lung, solution
The effect of poison, coordinating the drug actions of a prescription；For weakness of the spleen and the stomach, fatigue and weakness, severe palpilation, knotted pulse, detachable son poison.Radix Angelicae Sinensis is umbrella shape
The dry root of section plant Radix Angelicae Sinensis Angelica sinensis (Oliv.) Diels.There are replenishing and activating blood, regulating menstruation and relieving pain, moistening intestines and relaxing bowels
The effect of；For blood deficiency chlorosis, dizziness palpitaition, irregular menstruation, amenorrhea and algomenorrhea, asthenia cold abdominalgia, rheumatic arthralgia, injury from falling down, carbuncle
Subcutaneous ulcer sore, dry constipation of intestines.Prepared RADIX ANGELICAE SINENSIS with yellow rice wine blood circulation.For amenorrhea and algomenorrhea, rheumatic arthralgia, injury from falling down.Peach kernel is planted for rosaceae
The drying and ripening kind of object peach Prunus persica (L.) Batsch or mountain peach Prunus davidiana (Carr.) Franch.
Son；Major function promoting blood circulation, relax bowel and defecation.For menostasis, dysmenorrhea , wei lump in the abdomen lump in the abdomen, injury from falling down, dry constipation of intestines.Turtle shell is
The carapace of cyprinidae Trionyx sinensis Wiegmann；Major function nourishing and suppressing Yang, resolving hard lump are brought down a fever except steaming；
For fever due to yin deficiency, the hot hectic fever due to yin of labor, endogenous deficient wind, menostasis , wei lump in the abdomen, chronic malaria malaria with abdominal mass.Oyster, be Ostreidae animal Crassostrea rivularis,
The shell of long oyster or ostrea talienwhanensis Crosse etc.；Major function are as follows: hold back yin, checking exuberance of yang, hidroschesis, arresting seminal emission, resolving sputum, softening hard masses；Frightened epilepsy is controlled, it is dizzy
It is dizzy, spontaneous perspiration, night sweat, spermatorrhea, stranguria with turbid discharge, metrorrhagia and metrostaxis, leukorrhagia, scrofula, goiter；For insomnia of palpitating with fear, dizziness and tinnitus, tuberculous lymphadenitis, lump in the abdomen
Band, stomachache and sour regurgitation are collapsed in lump in the abdomen, spontaneous sweating, spermatorrhea.Rehmannia glutinosa is the rhizome of scrophulariaceae rehmannia glutinosa plant or bosom celebrating glutinous rehmannia, through adding
Work steaming is shone.Major function are as follows: enriching yin is enriched blood.It is few to control deficiency of Yin blood, waist knee flaccidity, Cough osteopyrexia, spermatorrhea, metrorrhagia and metrostaxis, menstruation is not
It adjusts, quenches one's thirst, number of urinating is deaf, blurred vision.White peony is the drying of ranunculaceae plant Chinese herbaceous peony Paeonia tacti lora Pall.
Root；With nourishing blood for regulating menstruation, the effect of astringing YIN to stop sweating, soft liver analgesic, suppressing liver-YANG；For blood deficiency chlorosis, irregular menstruation, spontaneous perspiration,
Night sweat, hypochondriac pain, abdominal pain, four limbs contraction pain, headache and dizziness.Fritillaria thunbergii is liliaceous plant fritillaria thunbergii Fritillaria
The dry bulb of thunbergii Miq.；Major function heat-clearing dissipating bind, preventing phlegm from forming and stopping coughing are used for wind-heat affecting lung, phlegm-fire cough, lung
Carbuncle, acute mastitis, scrofula, sore.Rhizoma pinellinae praeparata is the dry of aroid tuber of pinellia Pinellia ternata (Thunb.) Breit.
Dry stem tuber；Major function is eliminating dampness and eliminating phlegm, stopping nausea and vomiting by lowering the adverse flow of QI, dissolving lump and resolving mass；For abundant expectoration cough and asthma, phlegm retention anti-dazzle nervous, anemophlegmatic vertigo, coma due to blocking of the respiratory system
Headache, vomiting gastric disorder causing nausea, chest gastral cavity ruffian, globus hysteriocus；It is raw to use controlling outward carbuncle swells subcutaneous nodule.Dried orange peel is rutaceae orange Citrus
Reticulata Blanco and its dry mature skin of variety；Major function regulating qi-flowing for strengthening spleen is eliminating dampness and eliminating phlegm；For chest
Gastral cavity turgor, deficiency of food are vomited and diarrhoea, coughing with a lot of sputum.
Fang Xie: control " gas " with sun-dried ginseng, Rhizoma Atractylodis Macrocephalae, Poria cocos, radix glycyrrhizae preparata (Sijunzi Tang) help lung spleen gas, guarantee " storehouse report
Official " can continually supply substance, metaplasia energy.With trigone, curcuma zedoary promoting the circulation of qi relieving stagnant Qi, the two and the energy blood-breaking row stasis of blood.It controls
" blood " is enriched blood with Radix Angelicae Sinensis, Rehmannia glutinosa, white peony (Siwu Tang removes Rhizoma Chuanxiong) blood-nourishing, is disappeared sign with peach kernel, turtle shell, oyster broken stasis of blood.It controls
" water " is with fritillaria thunbergii, rhizoma pinellinae praeparata, dried orange peel reducing phlegm and resolving masses.Altogether at the drug for the benign tumors sexual stage, function Heibei provincial opera yin yin, Heibei provincial opera
Qi and blood, broken stasis of blood dissipate stagnant, and Drug is gentle, and fever and chills tendency is unobvious, are suitable for " cold disease ", " pyreticosis " alleged by seedling doctor.
Compared with prior art, the invention has the characteristics that:
With seedling doctor " three opinions ", " qi and blood water opinion ", the traditional medical theories such as Chinese medicine " equilibrium between yin and yang " are guidance.Think tumour
Morbidity arises from body yin and yang imbalance, shows as the energy using gas as representative and the insufficient and stasis of blood occurs using blood, water as the substance of representative
It is stagnant, it is formed to show textural anomaly i.e. tumour.By adjusting gas, blood, water equilibrium between yin and yang, reach adjustment substance, energy,
Between structure three and the respectively dynamic equilibrium of internal yin-yang.Drug of the invention is disappeared by promoting the circulation of qi Qi-tonifying drug, promoting blood circulation and is levied medicine and change
Phlegm dissipating bind medicine composition takes traditional Chinese medicine theory mutually to merge, penetrated through to improve traditional medicine and exist with the essence of the medical theory of seedling
Curative effect in oncotherapy.
Drug of the invention is gentle, and there is the negative yin of Heibei provincial opera, Heibei provincial opera qi and blood, broken stasis of blood to dissipate the benefits of stagnant, and heat symptom-complex, cold card are suitable
With.Practical for the treatment of benign tumors sexual stage, blocking its development in early days is malignant tumour, improves general health.Body
The not sick thought of the treatment of existing early prevention, curative for effect in clinical application, (knurl is reduced, is controlled total effective rate up to 70% or more
Chinese medicine syndrome integral Jian Shao≤70% after treatment).
The modern pharmacology base of drugs block tumor development of the invention will be illustrated by the method for network pharmacology below
Plinth and mechanism.Based on " qi and blood water " theory of seedling medicine, medicine of the invention is created in line with " controlling gas ", " harnessing the river ", " controlling blood " principle
Object, it is intended to which blocking tumor development is reached by disappear reducing phlegm and resolving masses of seeking peace of promoting the circulation of qi tonifying Qi, promoting blood circulation.With " controlling gas " monarch drug in a prescription ginseng, " control
Water " the monarch drug in a prescription tuber of pinellia is representative, " controlling blood " monarch drug in a prescription trigone (hereinafter referred to as " ginseng summer rib ") is analyzed as follows:
It completes to analyze using databases such as TCM, OMIM, GeneCards, STRING, KEGG.In the ingredient of ginseng summer rib
Oral administration biaavailability is filtered out greater than 30%, quasi-medicated property is greater than 0.18 ingredient (table 1), then finds out the effect target of these ingredients
Point (table 2).Target spot (table 3) relevant to tumour is found out from disease data, and intersection target between the two is taken by molecular docking
Point (Fig. 1).From interactions between protein figure (Fig. 3, Fig. 4) it is found that the genes such as CASP3, VEGFA, ESR1, FOS, CASP8, CASP9 with
Core position of other genes connection at most in effect.And CASP3, CASP8, CASP9 etc. are close with apoptosis of tumor cells
It is related.VEGFA is related to tumor migration, transfer.Tumour-ginseng summer rib)-ingredient-target spot regulated and control network is as shown in Figure 2.Again to friendship
Collect target spot and carries out function and path analysis (Fig. 5, Fig. 6).
By protein function enrichment analysis it is found that core target spot PGR (PgR), ESR1 (estrogen receptor 1), AR
(androgen receptor), PPARG (peroxisome proliferators activated receptor γ), ESR2 (estrogen receptor 2), CASP3,
CASP8, CASP9 etc. are mainly by steroid hormone receptor, by adjusting core in conjunction with the sequence specific DNA that ligand is adjusted
Receptor active and transcription factor activity.Other core target spots are then turned by conjunction with ubiquitin-like protein ligase, adjusting DNA and combining
Activation Activity is recorded, II specificity of RNA polymerase etc. plays a role.
Analysis is enriched with by access it is found that participating in Apoptosis letter by target gene BCL2, CASP9, CASP3, CASP8 etc.
Number access (Fig. 7) promotes apoptosis of tumor cells.Joined by target gene BCL2, CASP9, CASP3, CASP8, CHEK1, CCNB1 etc.
With P53 signal transduction pathway.P53 signal transduction pathway be by it is many stress signal induce, including DNA damage, oxidative stress
It is damaged with various kinds of cell early carcinomatous changes such as oncogene activations.P53 albumen can be stagnated with cell cycle regulation, cell ageing or be withered
It dies.So cell early carcinomatous change can be monitored in time by P53 signal path, early carcinomatous change is controlled in time, is blocked, prevention is reached
The purpose of malignant change of cell.Target gene can also may regulate and control inflammatory reaction by IL-17 signal path simultaneously, reduce cell damage
Wound reduces canceration probability.It can also show that target gene defines and colorectal cancer, carcinoma of prostate by access enrichment analysis
It is related.
In conclusion the effective component of ginseng summer rib can pass through class by genes such as CASP3, CASP8, CASP9, BCL2
Steroid hormone receptor adjusts nuclear receptor activities and transcription factor activity in conjunction with the sequence specific DNA that ligand is adjusted, and participates in thin
Born of the same parents' apoptosis signal transduction access mediates early malignant change Apoptosis, and early stage blocks benign tumour to develop into malignant tumour.Join the summer
The effective component of rib can participate in P53 signal transduction by target gene BCL2, CASP9, CASP3, CASP8, CHEK1, CCNB1 etc.
Access, the various kinds of cell early carcinomatous change damage such as real time monitoring DNA damage, oxidative stress and oncogene activation, timely DNA plerosis damage
Wound, oxidativestress damage (IL-17 signal path, TNF signal path, NF- κ B signal access, HIF-1 signal path) press down in time
Oncogene activation processed or promotion cancer cell removing, apoptosis etc., effectively block benign tumour to develop into malignant tumour.
Researching and analysing also found, ginseng summer rib can also act on cancer associated glycoprotein, prostate cancer (figure by effective component
12), colorectal cancer, Small Cell Lung Cancer and non-small cell lung cancer, breast cancer, carcinoma of endometrium, cancer of pancreas, cancerous tissue PD-l expression
And the phases such as the checkpoint PD-1, hepatocellular carcinoma, cancer choline metabolism, cancer MicroRNAs, clear-cell carcinoma, chronic myelogenous leukemia
OFF signal conduction path has a certain impact to the above malignant tumour.
So having from traditional seedling medicine theory and traditional Chinese medical theory, clinical practice and the analysis of network pharmacology mechanism of action
Effect, which demonstrates ginseng summer rib, has the function of early prevention benign tumour canceration, can effectively control its hair for the benign tumors sexual stage
It transforms into as malignant tumour.
The effective component of the ginseng summer rib of table 1
The action target spot (part) of the ginseng summer rib effective component of table 2
3 tumour correlation of table falls ill target spot (part)
The analysis of 4 genetic enrichment of table
The analysis of 5 gene pathway of table
In conclusion medicine property of medicine of the invention is gentle, there is the negative yin of Heibei provincial opera, Heibei provincial opera qi and blood, broken stasis of blood to dissipate the benefits of stagnant, it can be early
It is malignant tumour that phase, which blocks benign tumour development,.
Detailed description of the invention
Fig. 1 is tumour-ginseng summer rib intersection target spot schematic diagram；
Fig. 2 is tumour-ginseng summer rib-ingredient-target spot regulated and control network schematic diagram；
Fig. 3 is tumour-ginseng summer rib interactions between protein network diagram；
Fig. 4 is tumour-ginseng summer rib interactions between protein statistics schematic diagram；
Fig. 5 is tumour-ginseng summer rib gene function enrichment analysis chart；
Fig. 6 is tumour-ginseng summer rib gene pathway enrichment analysis chart；
Fig. 7 is apoptosis (Apoptosis) signal path figure；
Fig. 8 is the enlarged drawing of the upper left Fig. 7 a quarter part；
Fig. 9 is the enlarged drawing of Fig. 7 upper right a quarter part；
Figure 10 is the enlarged drawing of a quarter part on the lower-left Fig. 7；
Figure 11 is the enlarged drawing of the bottom right Fig. 7 a quarter part；
Figure 12 is prostate cancer associated signal paths；
Figure 13 is the enlarged drawing of the upper left Figure 12 a quarter part；
Figure 14 is the enlarged drawing of Figure 12 upper right a quarter part；
Figure 15 is the enlarged drawing of a quarter part on the lower-left Figure 12；
Figure 16 is the enlarged drawing of the bottom right Figure 12 a quarter part；
Sliceable Fig. 8,9,10,11 are Fig. 7；
Sliceable Figure 13,14,15,16 are Figure 12.
Specific embodiment
Below with reference to embodiment, the present invention is further illustrated, but is not intended as the foundation limited the present invention.
Embodiment 1: a kind of drug for the benign tumors sexual stage, effective medicinal components are by trigone 15g, curcuma zedoary 15g, sun-dried
Join 15g, Rhizoma Atractylodis Macrocephalae 15g, Poria cocos 15g, radix glycyrrhizae preparata 10g, Radix Angelicae Sinensis 20g, peach kernel 15g, turtle shell 15g, oyster 15g, Rehmannia glutinosa 10g, white
Chinese herbaceous peony 15g, fritillaria thunbergii 20g, rhizoma pinellinae praeparata 15g, dried orange peel 15g are made.
The drug is decoction, which is prepared: weighing said medicine in proportion, turtle shell and oyster are smashed, add
Enter the 2-4 times of water measured, be decocted first 30-60min.Again with the trigone after the 2-4 times of water measured impregnates 20-30min, curcuma zedoary, sun-dried is added
Ginseng, Rhizoma Atractylodis Macrocephalae, Poria cocos, radix glycyrrhizae preparata, Radix Angelicae Sinensis, peach kernel, Rehmannia glutinosa, white peony, fritillaria thunbergii, rhizoma pinellinae praeparata and dried orange peel mixing, then use sand
Pot is decocted with moderate heat to boiling, then decocts 20-25min with small fire, is filtered the dregs of a decoction while hot and is retained decocting liquid A, is added into the dregs of a decoction
The 2-4 times of water measured decocts 20-30min, filters the dregs of a decoction while hot and retains decocting liquid B, collecting decoction A and decocting liquid B to get the decoction.
Usage and dosage: oral, 200ml/ times, 3 times/day, half an hour warmly takes before meals.
Embodiment 2: a kind of drug for the benign tumors sexual stage, effective medicinal components are by trigone 50g, curcuma zedoary 50g, sun-dried
Join 50g, Rhizoma Atractylodis Macrocephalae 50g, Poria cocos 50g, radix glycyrrhizae preparata 10g, Radix Angelicae Sinensis 100g, peach kernel 50g, turtle shell 50g, oyster 50g, Rehmannia glutinosa 11g, white
Chinese herbaceous peony 52g, fritillaria thunbergii 100g, rhizoma pinellinae praeparata 50g, dried orange peel 50g are made.
The drug is granule, which is prepared: weighing said medicine in proportion, is ground into most coarse powder, adds
Water impregnates 20min, decocts three times, each 30min, collecting decoction, filtration, and relative density is 1.34 when filtrate is concentrated into 80 DEG C
Thick paste is added the dextrin of the amount of being made 33%, the sucrose of the amount of being made 48%, mixes, and particle is made, dry to get the granule.
Usage and dosage: half an hour warm water is taken after mixing it with water before meals, 2-3 times daily, 2-3 bags each.
Embodiment 3: a kind of drug for the benign tumors sexual stage, effective medicinal components are by trigone 25g, curcuma zedoary 25g, sun-dried
Join 25g, Rhizoma Atractylodis Macrocephalae 25g, Poria cocos 25g, radix glycyrrhizae preparata 15g, Radix Angelicae Sinensis 30g, peach kernel 25g, turtle shell 25g, oyster 25g, Rehmannia glutinosa 15g, white
Chinese herbaceous peony 25g, fritillaria thunbergii 30g, rhizoma pinellinae praeparata 25g, dried orange peel 25g are made.
The drug is soft extract, which is prepared: weighing said medicine in proportion, is ground into most thick
Powder soaks in water 20-30min, decocts 3 times, and the water measured for the first time with 12 times decocts 3 hours, and second of the water measured with 8 times decocts
2 hours, the water measured for the third time with 6 times decocted 0.5 hour, collecting decoction, filtration, relative density when being condensed into 60-65 DEG C
The medicinal extract of 1.10-1.15, is then added the honey of medicinal extract amount 50% in medicinal extract, and heating is mixed, is concentrated into opposite at 60-65 DEG C
Density is the medicinal extract of 1.2-1.25 to get the soft extract.
Usage and dosage: half an hour warm water is taken after mixing it with water before meals, 2-3 times daily, each 10-30g.
Claims (8)
1. a kind of drug for the benign tumors sexual stage, it is characterised in that: effective medicinal components are calculated according to composition by weight, by trigone
5-25 parts, 5-25 parts of curcuma zedoary, 5-25 parts of sun-dried ginseng, 5-25 parts of Rhizoma Atractylodis Macrocephalae, 5-25 parts of Poria cocos, 1-15 parts of radix glycyrrhizae preparata, Radix Angelicae Sinensis 10-30
Part, 5-25 parts of peach kernel, 5-25 parts of turtle shell, 5-25 parts of oyster, 1-15 parts of Rehmannia glutinosa, 5-25 parts of white peony, 10-30 parts of fritillaria thunbergii,
5-25 parts of rhizoma pinellinae praeparata, 5-25 parts of dried orange peel be made.
2. the drug according to claim 1 for the benign tumors sexual stage, it is characterised in that: the effective medicinal components shine
Composition by weight calculates, by 15 parts of trigone, 15 parts of curcuma zedoary, 15 parts of sun-dried ginseng, 15 parts of Rhizoma Atractylodis Macrocephalae, 15 parts of Poria cocos, 10 parts of radix glycyrrhizae preparata, Radix Angelicae Sinensis
20 parts, 15 parts of peach kernel, 15 parts of turtle shell, 15 parts of oyster, 10 parts of Rehmannia glutinosa, 15 parts of white peony, 20 parts of fritillaria thunbergii, 15 parts of rhizoma pinellinae praeparata,
15 parts of dried orange peel are made.
3. a kind of preparation method for the drug of benign tumors sexual stage as claimed in claim 1 or 2, it is characterised in that: take
Drug is stated, is combined with auxiliary material acceptable in drug, or auxiliary material is not added, is conventionally processed, is made corresponding
Pharmaceutical preparation.
4. the preparation method for the drug of benign tumors sexual stage according to claim 3, it is characterised in that: the drug system
Agent is oral preparation.
5. the preparation method for the drug of benign tumors sexual stage according to claim 4, it is characterised in that: the oral system
Agent is decoction, granule or soft extract.
6. according to claim 5 for the benign tumors sexual stage drug preparation method, it is characterised in that: the decoction this
Sample preparation: weighing said medicine in proportion, turtle shell and oyster smashed, and the 2-4 times of water measured is added, be decocted first 30-60min.Again with
The trigone after the 2-4 times of water measured impregnates 20-30min, curcuma zedoary, sun-dried ginseng, Rhizoma Atractylodis Macrocephalae, Poria cocos, radix glycyrrhizae preparata, Radix Angelicae Sinensis, peach kernel, ripe is added
Glutinous rehmannia, white peony, fritillaria thunbergii, rhizoma pinellinae praeparata and dried orange peel mixing, are then decocted with moderate heat to boiling with casserole, then decocted with small fire
20-25min filters the dregs of a decoction while hot and retains decocting liquid A, the 2-4 times of water measured is added into the dregs of a decoction, decocts 20-30min, filters while hot
The dregs of a decoction retain decocting liquid B, collecting decoction A and decocting liquid B to get the decoction.
7. the preparation method for the drug of benign tumors sexual stage according to claim 5, it is characterised in that: the granule
It is prepared: weighing said medicine in proportion, be ground into most coarse powder, soak in water 20-30min, decoct three times, each 30min,
The paste of the amount of being made 33% is added in collecting decoction, filtration, the thick paste that relative density is 1.30~1.35 when filtrate is concentrated into 80 DEG C
The sucrose of essence, the amount of being made 48% mixes, and particle is made, dry to get the granule.
8. the preparation method for the drug of benign tumors sexual stage according to claim 5, it is characterised in that: the soft extract
It is prepared: weighing said medicine in proportion, be ground into most coarse powder, soak in water 20-30min, decoct 3 times, for the first time with 12
The water of amount decocts 3 hours again, and for the second time with the water decoction of 8 times of amounts 2 hours, the water measured for the third time with 6 times is decocted 0.5 hour, conjunction
And then medicinal extract amount is added in decocting liquid, filtration, the medicinal extract for the 1.10-1.15 that relative density is when being condensed into 60-65 DEG C in medicinal extract
50% honey, heating mix, and relative density is the medicinal extract of 1.2-1.25 to get the soft extract when being concentrated into 60-65 DEG C.
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| CN116036217A (en) * | 2022-12-23 | 2023-05-02 | 广西中医药大学第一附属医院 | Traditional Chinese medicine compound granule for treating primary liver cancer and preparation method thereof |
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| CN116036217B (en) * | 2022-12-23 | 2023-11-21 | 广西中医药大学第一附属医院 | Traditional Chinese medicine compound granule for treating primary liver cancer and preparation method thereof |
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Application publication date: 20191108 |