CN114344433B - Yin-nourishing and jade-moistening ointment formula and application thereof - Google Patents
Yin-nourishing and jade-moistening ointment formula and application thereof Download PDFInfo
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Abstract
The invention relates to a yin-nourishing and jade-moistening ointment formula which is prepared from the following raw material medicines in parts by weight: 90 parts of American ginseng, 110-130 parts of Chinese angelica root, 90-110 parts of epimedium, 90 parts of vinegar-processed radix bupleuri, 150 parts of white poria, 60 parts of Chinese rose, 60 parts of starwort root, 90 parts of rhizoma anemarrhenae, 120 parts of radix rehmanniae recen, 120 parts of prepared rehmannia root, 90 parts of radix curcumae, 90 parts of tender curculigo orchioides, 100 parts of red paeony root, 100 parts of white paeony root, 90 parts of glossy privet fruit, 140-160 parts of light wheat, 150 parts of Huai wheat, 60 parts of fried amur corktree bark, 90 parts of shrunken peach stem, 100 parts of pulp of dogwood fruit, 90 parts of fingered citron slice, 90 parts of flos mume, 90 parts of prepared rhizoma cyperi, 90 parts of fried fructus aurantii, 90 parts of cortex albiziae, 60 parts of spina date seed, 140-160 parts of tuber fleeceflower stem, 90 parts of mongolian snakegourd root, 150 parts of dendrobium, 90 parts of rhizoma polygonati, 60 parts of honey-fried licorice root, 90 parts of Chinese date, 90 parts of walnut meat and the like. The invention also provides the application of the yin-nourishing and jade-moistening ointment formula. The traditional Chinese medicine composition has the effects of nourishing yin, clearing heat, soothing liver, relieving depression, replenishing blood, activating blood, improving and treating yin deficiency constitution and qi depression constitution of perimenopausal women, and has a remarkable effect.
Description
Technical Field
The invention relates to the field of traditional Chinese medicines, in particular to a yin-nourishing and jade-moistening ointment formula and application thereof.
Background
The traditional Chinese medicine health-preserving paste formula is a semifluid preparation prepared by repeatedly decocting traditional Chinese medicine decoction pieces according to the traditional Chinese medicine principle, removing residues to obtain juice, evaporating and concentrating, and adding sugar, honey or donkey-hide gelatin and the like, has good effects on weak and susceptible people, sub-health states, chronic diseases, children, women, old people and other special crowds, and is increasingly widely applied to modern clinic.
In long-term clinical practice, the applicant uses a self-prepared yin-nourishing jade ointment formula to perform intervention treatment on perimenopausal women with yin-deficiency constitution and qi-stagnation constitution in winter seasons, and can remarkably improve symptom expression qi deficiency of perimenopausal women with yin-deficiency constitution and qi-stagnation constitution. The basic formula of the yin nourishing and jade moistening ointment formula comprises: american ginseng 90 g, starwort root 60 g, vinegar processed bupleurum 90 g, fertile anemarrhena 60 g, guanhuangbai bark 60 g, shrunken peach 90 g, dried rehmannia root, prepared rehmannia root 120 g each, cornus officinalis 100 g, curcuma aromatica 90 g, finger citron 90 g, green calyx prune 90 g, chinese rose 60 g, angelica root 120 g, red peony root, white peony root 100 g each, fried ligusticum wallichii 150 g, prepared cyperus tuber 90 g, fried bitter orange 90 g, poria cocos 120 g, albizia bark 90 g, wild jujube seed 60 g, tuber fleeceflower 150 g, trichosanthes root 90 g, dendrobium 60 g, polygonatum 90 g, honey-fried licorice root 60 g, red jujube 100 g, walnut meat 100 g, lotus seed meat 100 g, wolfberry 100 g and black sesame 100 g. The medicines are decocted in a thick mode, dregs are removed, and 400 g of donkey-hide gelatin, 250 g of white honey and 250 g of yellow wine are added into the thick juice to be melted and collected into paste.
In the later practical process, the applicant adjusts to obtain another prescription on the basis of earlier work, and animal experiments prove that the effect is more remarkable.
Disclosure of Invention
The invention aims to provide a formula of jade paste for nourishing yin aiming at the defects in the prior art.
The invention further aims to provide application of the yin-nourishing and jade-moistening ointment formula.
In order to achieve the first purpose, the invention adopts the technical scheme that: the yin-nourishing and jade-moistening ointment formula is prepared from the following raw material medicines in parts by weight: 90 parts of American ginseng, 110-130 parts of Chinese angelica, 90-110 parts of herba epimedii, 90 parts of vinegar radix bupleuri, 150 parts of white poria, 60 parts of Chinese rose, 60 parts of starwort root, 90 parts of rhizoma anemarrhenae, 120 parts of radix rehmanniae recen, 120 parts of prepared rehmannia root, 90 parts of radix curcumae, 90 parts of tender rhizoma curculiginis, 100 parts of red paeony root, 100 parts of white paeony root, 90 parts of glossy privet fruit, 140-160 parts of light wheat, 150 parts of Huai wheat, 60 parts of fried golden cypress, 90 parts of shrunken peach, 100 parts of pulp of dogwood fruit, 90 parts of fingered citron slice, 90 parts of calyx prunus mume, 90 parts of prepared rhizoma cyperi, 90 parts of fried fructus aurantii, 90 parts of cortex albiziae, 60 parts of spina date seed, 140-160 parts of tuber fleeceflower stem, 90 parts of trichosanthes root, 150 parts of dendrobe, 90 parts of rhizoma polygonati, 60 parts of Chinese date, 90 parts of walnut meat, 90 parts of honey-fried licorice, 150 parts of donkey-hide gelatin, 60 parts of turtle shell glue, 60 parts of tortoise-plastron glue, 250 parts of maltose, 250 parts of yellow rice wine.
Preferably, the yin nourishing and jade moistening ointment formula is prepared from the following raw material medicines in parts by weight: 90 parts of American ginseng, 115-125 parts of Chinese angelica, 95-105 parts of herba epimedii, 90 parts of vinegar radix bupleuri, 150 parts of white poria, 60 parts of Chinese rose, 60 parts of starwort root, 90 parts of rhizoma anemarrhenae, 120 parts of radix rehmanniae recen, 120 parts of prepared rehmannia root, 90 parts of radix curcumae, 90 parts of tender rhizoma curculiginis, 100 parts of red paeony root, 100 parts of white paeony root, 90 parts of glossy privet fruit, 145-155 parts of light wheat, 150 parts of Huai wheat, 60 parts of fried golden cypress, 90 parts of shrunken peach, 100 parts of pulp of dogwood fruit, 90 parts of fingered citron slice, 90 parts of prunus mume, 90 parts of prepared rhizoma cyperi, 90 parts of fried fructus aurantii, 90 parts of cortex albiziae, 60 parts of spina date seed, 145-155 parts of tuber fleeceflower stem, 90 parts of trichosanthes root, 150 parts of dendrobe, 90 parts of rhizoma polygonati, 60 parts of Chinese date, 90 parts of walnut pulp, 90 parts of honey-fried licorice, 150 parts of donkey-hide gelatin, 60 parts of turtle shell glue, 60 parts of tortoise-plastron glue, 250 parts of tortoise-shell glue, 250 parts of maltose, 250 parts of yellow wine.
More preferably, the yin nourishing and jade moistening ointment formula is prepared from the following raw material medicines in parts by weight: 90 parts of American ginseng, 120 parts of angelica, 100 parts of herba epimedii, 90 parts of vinegar-processed radix bupleuri, 150 parts of poria alba, 60 parts of Chinese rose, 60 parts of starwort root, 90 parts of fat rhizoma anemarrhenae, 120 parts of radix rehmanniae, 120 parts of prepared rehmannia root, 90 parts of radix curcumae, 90 parts of tender rhizoma curculiginis, 100 parts of red paeony root, 100 parts of white paeony root, 90 parts of glossy privet fruit, 150 parts of light wheat, 150 parts of Huai wheat, 60 parts of fried golden cypress, 90 parts of shrubby peach stem, 100 parts of pulp of dogwood fruit, 90 parts of fingered citron slice, 90 parts of flos mume, 90 parts of prepared nutgrass galingale rhizome, 90 parts of fried fructus aurantii, 90 parts of cortex albiziae, 60 parts of spina date seed, 150 parts of tuber fleeceflower stem, 90 parts of mongolian snakegourd root, 150 parts of dendrobium, 90 parts of rhizoma polygonati, 60 parts of honey-fried licorice root, 90 parts of Chinese date, 90 parts of walnut meat, 90 parts of lotus seed pulp, 150 parts of donkey-hide gelatin, 150 parts of turtle shell glue, 60 parts of tortoise plastron glue, 250 parts of maltose, 250 parts of white honey and 250 parts of yellow rice wine.
In order to achieve the second purpose, the invention adopts the technical scheme that:
the application of the yin-nourishing and jade-moistening paste formula in preparing foods, health-care products or medicines for improving the constitution of yin deficiency of perimenopausal women or the constitution symptom of qi depression of perimenopausal women.
The invention has the advantages that:
1. the treatment principle of the invention is as follows: nourishing yin, clearing away heat, soothing liver, relieving depression, replenishing blood and promoting blood circulation
Compatibility of medicines: the yin nourishing and jade moistening ointment formula is prepared by reducing and cutting basic traditional Chinese medicine formulas of Dizhi pill, erxian decoction, xiaoyao powder, radix bupleuri and liver soothing powder and Zhibai Dihuang pill. In the prescription medication aspect, the prepared rehmannia root, the angelica, the donkey-hide gelatin, the turtle shell gelatin and the tortoise-plastron gelatin are used together, so that the blood and the yin are enriched, and the essence and the marrow are also enriched; the glossy privet fruit and the American ginseng have the effects of nourishing yin and enriching blood, promoting the production of body fluid and moistening dryness, while the American ginseng has the effects of clearing and nourishing qi and yin, and clearing heat and promoting the production of body fluid; fructus Corni has effects in nourishing liver and kidney, astringing and inducing astringency; tender Xian Mao and Xian Ling Pi warm kidney yang, tonify kidney essence, and have the actions of tonifying kidney essence, regulating thoroughfare and conception vessels by warming kidney yang, and regulating yin by yang, they are the monarch drugs.
In the recipe, liver-soothing and qi-regulating herbs are added, white peony root has the effects of liver softening, blood nourishing and yin astringing, and fried bitter orange, chinese rose flower, fingered citron tablet, rose, vinegar-processed radix bupleuri, radix curcumae, flos cuprifoliae mume and prepared rhizoma cyperi are used for soothing the liver and relieving depression and also for relieving pain and regulating the middle warmer; trichosanthes root, dendrobium, and rhizoma polygonati have the effects of nourishing yin and clearing heat; radix rehmanniae is used for clearing heat and cooling blood; regulating menstruation and promoting blood circulation; the white poria cocos wolf has the effects of tonifying spleen and soothing nerves, is used as ministerial drug.
Meanwhile, radix Stellariae can clear and reduce deficiency heat, and rhizoma anemarrhenae and fried cortex phellodendri are used in mutual reinforcement to achieve the functions of clearing heat and purging fire, and nourishing yin and moistening dryness; the light wheat and the Huai wheat are matched for clearing deficiency heat and arresting sweating; flat peach and dry peach to promote the production of body fluid and stop sweating; cortex Albizziae, semen Ziziphi Spinosae and caulis Polygoni Multiflori are used as adjuvant drugs for tranquilizing mind.
Prepared licorice, chinese date, walnut meat, lotus seed meat, maltose, white honey and yellow wine are used as guiding drugs for harmonizing the drugs in the recipe.
2. Animal experiments show that the yin-nourishing and jade-moistening ointment formula has obvious effects on vascular calcification and blood pressure of yin-deficiency and yang-hyperactivity type hypertensive rats and has obvious effects.
Detailed Description
The following provides a detailed description of specific embodiments of the present invention.
Example 1 preparation of a Yin-nourishing and Jade-moisturizing formula of the invention
90 parts of American ginseng, 120 parts of angelica sinensis, 100 parts of herba epimedii, 90 parts of vinegar radix bupleuri, 150 parts of white poria, 60 parts of Chinese rose, 60 parts of starwort root, 90 parts of fat rhizoma anemarrhenae, 120 parts of radix rehmanniae, 120 parts of prepared rehmannia root, 90 parts of wide radix curcumae, 90 parts of tender rhizoma curculiginis, 100 parts of red paeony root, 100 parts of white paeony root, 90 parts of glossy privet fruit, 150 parts of light wheat, 150 parts of Huai wheat, 60 parts of fried golden cypress, 90 parts of dried peach, 100 parts of pulp of dogwood fruit, 90 parts of fingered citron piece, 90 parts of flos Pruni mume, 90 parts of prepared nutgrass galingale rhizome, 90 parts of fried fructus aurantii, 90 parts of cortex albiziae, 60 parts of tuber fleeceflower stem, 150 parts of radix trichosanthis, 150 parts of dendrobe, 90 parts of rhizoma polygonati, 60 parts of honey-fried licorice, 90 parts of Chinese date, 90 parts of walnut meat, 90 parts of lotus seed meat, 60 parts of turtle shell glue and 60 parts of tortoise plastron glue, the concentrated decoction is obtained, dregs are removed, and decocted, 150 parts of donkey-hide glue, 250 parts of sugar, 250 parts of rice wine and 250 parts of honey are added into the concentrated decoction.
Example 2 preparation of a Yin-nourishing and Jade-moisturizing formulation of the invention
90 parts of American ginseng, 120 parts of angelica sinensis, 90 parts of herba epimedii, 90 parts of vinegar radix bupleuri, 150 parts of white poria, 60 parts of Chinese rose, 60 parts of starwort root, 90 parts of fat rhizoma anemarrhenae, 120 parts of radix rehmanniae, 120 parts of prepared rehmannia root, 90 parts of wide radix curcumae, 90 parts of tender rhizoma curculiginis, 100 parts of red paeony root, 100 parts of white paeony root, 90 parts of glossy privet fruit, 160 parts of light wheat, 150 parts of Huai wheat, 60 parts of fried golden cypress, 90 parts of shrubby peach, 100 parts of pulp of dogwood fruit, 90 parts of fingered citron piece, 90 parts of flos Pruni mume, 90 parts of prepared nutgrass galingale rhizome, 90 parts of fried fructus aurantii, 90 parts of cortex albiziae, 60 parts of tuber fleeceflower stem, 145 parts of radix trichosanthis, 150 parts of dendrobium, 90 parts of rhizoma polygonati, 60 parts of honey-fried licorice, 90 parts of Chinese date, 90 parts of walnut meat, 90 parts of lotus seed meat, 60 parts of turtle shell glue and 60 parts of tortoise plastron glue, the concentrated decoction is taken, the above medicines are deslagged and decocted, 150 parts of donkey-hide glue, 250 parts of sugar, 250 parts of rice wine and honey-melting paste are added.
EXAMPLE 3 preparation of the Yin nourishing and moisturizing formula of the invention
90 parts of American ginseng, 110 parts of angelica, 110 parts of herba epimedii, 90 parts of vinegar-processed radix bupleuri, 150 parts of chinaroot greenbrier rhizome, 60 parts of Chinese rose flower, 60 parts of rose, 60 parts of starwort root, 90 parts of fat rhizoma anemarrhenae, 120 parts of radix rehmanniae, 120 parts of prepared rehmannia root, 90 parts of radix curcumae, 90 parts of tender rhizoma curculiginis, 100 parts of red paeony root, 100 parts of white paeony root, 90 parts of glossy privet fruit, 145 parts of light wheat, 150 parts of Huai wheat, 60 parts of fried golden cypress, 90 parts of shrunken peach stem, 100 parts of pulp of dogwood fruit, 90 parts of fingered citron slice, 90 parts of flos mume, 90 parts of prepared nutgrass galingale rhizome, 90 parts of fried fructus aurantii, 90 parts of cortex albiziae, 60 parts of spina date seed, 155 parts of tuber fleeceflower stem, 90 parts of mongolian snakegourd root, 150 parts of dendrobium, 90 parts of rhizoma polygonati, 60 parts of honey-fried licorice root, 90 parts of Chinese date, 90 parts of walnut meat, 90 parts of lotus seed meat, 60 parts of turtle shell gum, 60 parts of tortoise plastron glue, 60 parts of thick decoction, and dregs are removed, 150 parts of thick juice are taken, and the residue is added into the thick juice, 250 parts of donkey-hide gelatin, 250 parts of syrup, 250 parts of white maltose, yellow rice wine and melted paste are obtained.
Example 4 preparation of a Yin-nourishing and Jade-moisturizing formulation of the invention
90 parts of American ginseng, 130 parts of angelica sinensis, 95 parts of herba epimedii, 90 parts of vinegar-processed radix bupleuri, 150 parts of chinaroot greenbrier rhizome, 60 parts of Chinese rose flower, 60 parts of rose, 60 parts of starwort root, 90 parts of fat rhizoma anemarrhenae, 120 parts of radix rehmanniae, 120 parts of prepared rehmannia root, 90 parts of radix curcumae, 90 parts of tender rhizoma curculiginis, 100 parts of red paeony root, 100 parts of white paeony root, 90 parts of glossy privet fruit, 155 parts of light wheat, 150 parts of Huai wheat, 60 parts of fried golden cypress, 90 parts of shrunken peach stem, 100 parts of pulp of dogwood fruit, 90 parts of fingered citron slice, 90 parts of flos mume, 90 parts of prepared nutgrass galingale rhizome, 90 parts of fried fructus aurantii, 90 parts of cortex albiziae, 60 parts of spina date seed, 150 parts of tuber fleeceflower stem, 90 parts of mongolian snakegourd root, 150 parts of dendrobium, 90 parts of rhizoma polygonati, 60 parts of honey-fried licorice root, 90 parts of Chinese date, 90 parts of walnut meat, 90 parts of lotus seed meat, 60 parts of turtle shell gum and 60 parts of tortoise plastron glue, the thick juice is taken, the thick, the decoction is subjected to residue is removed, and 150 parts of donkey-hide, 250 parts of donkey-hide gelatin, 250 parts of yellow rice wine and melted paste are added into the thick juice.
Example 5 preparation of a Yin-nourishing and Jade-moisturizing formula of the invention
90 parts of American ginseng, 115 parts of angelica sinensis, 105 parts of herba epimedii, 90 parts of vinegar radix bupleuri, 150 parts of white poria, 60 parts of Chinese rose, 60 parts of starwort root, 90 parts of rhizoma anemarrhenae, 120 parts of radix rehmanniae, 120 parts of prepared rehmannia root, 90 parts of radix curcumae, 90 parts of tender rhizoma curculiginis, 100 parts of red paeony root, 100 parts of white paeony root, 90 parts of glossy privet fruit, 150 parts of light wheat, 150 parts of Huai wheat, 60 parts of fried golden cypress, 90 parts of dried peach, 100 parts of pulp of dogwood fruit, 90 parts of fingered citron slice, 90 parts of flos Pruni mume, 90 parts of prepared nutgrass galingale rhizome, 90 parts of fried fructus aurantii, 90 parts of cortex albiziae, 60 parts of tuber fleeceflower stem, 140 parts of radix trichosanthis, 150 parts of dendrobium, 90 parts of rhizoma polygonati, 60 parts of honey-fried licorice, 90 parts of Chinese date, 90 parts of walnut meat, 90 parts of lotus seed meat, 60 parts of turtle shell glue and 60 parts of tortoise plastron glue, the concentrated decoction is obtained, dregs are removed, and decocted, 150 parts of donkey-hide glue, 250 parts of sugar, 250 parts of rice wine and honey are added into the concentrated decoction.
EXAMPLE 6 preparation of the Yin nourishing and moisturizing formula (VI)
90 parts of American ginseng, 125 parts of angelica sinensis, 100 parts of herba epimedii, 90 parts of vinegar radix bupleuri, 150 parts of white poria, 60 parts of Chinese rose, 60 parts of starwort root, 90 parts of rhizoma anemarrhenae, 120 parts of radix rehmanniae, 120 parts of prepared rehmannia root, 90 parts of radix curcumae, 90 parts of tender rhizoma curculiginis, 100 parts of red paeony root, 100 parts of white paeony root, 90 parts of glossy privet fruit, 140 parts of light wheat, 150 parts of Huai wheat, 60 parts of fried golden cypress, 90 parts of dried peach, 100 parts of pulp of dogwood fruit, 90 parts of fingered citron slice, 90 parts of flos Pruni mume, 90 parts of prepared nutgrass galingale rhizome, 90 parts of fried fructus aurantii, 90 parts of cortex albiziae, 60 parts of tuber fleeceflower stem, 160 parts of radix trichosanthis, 150 parts of dendrobium, 90 parts of rhizoma polygonati, 60 parts of honey-fried licorice, 90 parts of Chinese date, 90 parts of walnut pulp, 90 parts of lotus seed pulp, 60 parts of turtle shell glue and 60 parts of tortoise plastron glue, the concentrated decoction is obtained, dregs are removed, and decocted, 150 parts of donkey-hide glue, 250 parts of sugar, 250 parts of rice wine and honey are added into the concentrated decoction.
Example 7 preparation of a formula of yin-nourishing and jade cream of the invention
90 parts of American ginseng, 120 parts of angelica, 110 parts of herba epimedii, 90 parts of vinegar radix bupleuri, 150 parts of white poria, 60 parts of Chinese rose, 60 parts of starwort root, 90 parts of rhizoma anemarrhenae, 120 parts of radix rehmanniae, 120 parts of prepared rehmannia root, 90 parts of radix curcumae, 90 parts of tender rhizoma curculiginis, 100 parts of red paeony root, 100 parts of white paeony root, 90 parts of glossy privet fruit, 145 parts of light wheat, 150 parts of Huai wheat, 60 parts of fried golden cypress, 90 parts of dried peach, 100 parts of pulp of dogwood fruit, 90 parts of fingered citron slice, 90 parts of flos Pruni mume, 90 parts of prepared nutgrass galingale rhizome, 90 parts of fried fructus aurantii, 90 parts of cortex albiziae, 60 parts of tuber fleeceflower stem, 155 parts of radix trichosanthis, 150 parts of dendrobium, 90 parts of rhizoma polygonati, 60 parts of honey-fried licorice, 90 parts of Chinese date, 90 parts of walnut meat, 90 parts of lotus seed meat, 60 parts of turtle shell glue and 60 parts of tortoise plastron glue, the concentrated decoction is obtained, and the residue is removed and decocted, 150 parts of donkey-hide glue, 250 parts of honey paste are added into the concentrated decoction.
EXAMPLE 8 preparation of the Yin nourishing and moisturizing formula (VIII)
90 parts of American ginseng, 110 parts of angelica, 95 parts of herba epimedii, 90 parts of vinegar-processed radix bupleuri, 150 parts of chinaroot greenbrier rhizome, 60 parts of Chinese rose flower, 60 parts of rose, 60 parts of starwort root, 90 parts of fat rhizoma anemarrhenae, 120 parts of radix rehmanniae, 120 parts of prepared rehmannia root, 90 parts of radix curcumae, 90 parts of tender rhizoma curculiginis, 100 parts of red paeony root, 100 parts of white paeony root, 90 parts of glossy privet fruit, 145 parts of light brown, 150 parts of common yam rhizome, 60 parts of fried golden cypress, 90 parts of dried peach, 100 parts of pulp of dogwood fruit, 90 parts of fingered citron slice, 90 parts of flos mume, 90 parts of prepared nutgrass galingale rhizome, 90 parts of fried nutgrass galingale rhizome, 90 parts of cortex albiziae, 60 parts of bitter orange, 150 parts of tuber fleeceflower stem, 90 parts of mongolian snakegourd root, 150 parts of dendrobium, 90 parts of rhizoma polygonati, 60 parts of honey-fried licorice root, 90 parts of Chinese date, 90 parts of walnut meat, 90 parts of lotus seed meat, 60 parts of turtle shell glue and 60 parts of tortoise plastron glue, the medicinal herbs are decocted in a thick decoction, residues are removed, 150 parts of thick decoction are taken, 150 parts of donkey-hide gelatin, 250 parts of honey is added, 250 parts of yellow wine and paste is melted.
EXAMPLE 9 preparation of the Yin-nourishing and Jade-moisturizing cream formulation of the present invention (nine)
90 parts of American ginseng, 130 parts of angelica sinensis, 105 parts of herba epimedii, 90 parts of vinegar radix bupleuri, 150 parts of white poria, 60 parts of Chinese rose, 60 parts of starwort root, 90 parts of rhizoma anemarrhenae, 120 parts of radix rehmanniae, 120 parts of prepared rehmannia root, 90 parts of radix curcumae, 90 parts of tender rhizoma curculiginis, 100 parts of red paeony root, 100 parts of white paeony root, 90 parts of glossy privet fruit, 150 parts of light wheat, 150 parts of Huai wheat, 60 parts of fried golden cypress, 90 parts of dried peach, 100 parts of pulp of dogwood fruit, 90 parts of fingered citron slice, 90 parts of flos Pruni mume, 90 parts of prepared nutgrass galingale rhizome, 90 parts of fried fructus aurantii, 90 parts of cortex albiziae, 60 parts of tuber fleeceflower stem, 140 parts of radix trichosanthis, 150 parts of dendrobium, 90 parts of rhizoma polygonati, 60 parts of honey-fried licorice, 90 parts of Chinese date, 90 parts of walnut pulp, 90 parts of lotus seed pulp, 60 parts of turtle shell glue and 60 parts of tortoise plastron glue, the concentrated decoction is obtained, dregs are removed, and decocted, 150 parts of donkey-hide glue, 250 parts of sugar, 250 parts of rice wine and honey are added into the concentrated decoction.
Example 10 preparation of a Yin-nourishing and Jade-moisturizing formulation of the invention (ten)
90 parts of American ginseng, 115 parts of angelica sinensis, 100 parts of herba epimedii, 90 parts of vinegar-processed radix bupleuri, 150 parts of chinaroot greenbrier rhizome, 60 parts of Chinese rose flower, 60 parts of rose, 60 parts of starwort root, 90 parts of fat rhizoma anemarrhenae, 120 parts of radix rehmanniae, 120 parts of prepared rehmannia root, 90 parts of radix curcumae, 90 parts of tender rhizoma curculiginis, 100 parts of red paeony root, 100 parts of white paeony root, 90 parts of glossy privet fruit, 140 parts of light wheat, 150 parts of Huai wheat, 60 parts of fried golden cypress, 90 parts of shrunken peach stem, 100 parts of pulp of dogwood fruit, 90 parts of fingered citron slice, 90 parts of flos mume, 90 parts of prepared nutgrass galingale rhizome, 90 parts of fried fructus aurantii, 90 parts of cortex albiziae, 60 parts of spina date seed, 160 parts of tuber fleeceflower stem, 90 parts of mongolian snakegourd root, 150 parts of dendrobium, 90 parts of rhizoma polygonati, 60 parts of honey-fried licorice root, 90 parts of Chinese date, 90 parts of walnut meat, 90 parts of lotus seed meat, 60 parts of turtle shell gum and 60 parts of tortoise plastron glue, the thick juice is taken, the thick juice is decocted, dregs are removed, and 150 parts of donkey-hide gelatin, 250 parts of melted syrup is added.
Example 11 preparation of a Yin-nourishing and Jade-moisturizing formulation of the invention (eleven)
90 parts of American ginseng, 125 parts of angelica sinensis, 90 parts of herba epimedii, 90 parts of vinegar radix bupleuri, 150 parts of white poria, 60 parts of Chinese rose, 60 parts of starwort root, 90 parts of fat rhizoma anemarrhenae, 120 parts of radix rehmanniae, 120 parts of prepared rehmannia root, 90 parts of wide radix curcumae, 90 parts of tender rhizoma curculiginis, 100 parts of red paeony root, 100 parts of white paeony root, 90 parts of glossy privet fruit, 160 parts of light wheat, 150 parts of Huai wheat, 60 parts of fried golden cypress, 90 parts of shrubby peach, 100 parts of pulp of dogwood fruit, 90 parts of fingered citron piece, 90 parts of flos Pruni mume, 90 parts of prepared nutgrass galingale rhizome, 90 parts of fried fructus aurantii, 90 parts of cortex albiziae, 60 parts of tuber fleeceflower stem, 145 parts of radix trichosanthis, 150 parts of dendrobium, 90 parts of rhizoma polygonati, 60 parts of honey-fried licorice, 90 parts of Chinese date, 90 parts of walnut meat, 90 parts of lotus seed meat, 60 parts of turtle shell glue and 60 parts of tortoise plastron glue, the concentrated decoction is taken, the above medicines are deslagged and decocted, 150 parts of donkey-hide glue, 250 parts of sugar, 250 parts of rice wine and honey-melting paste are added.
Example 12
Experimental study on influence of yin-nourishing and jade-moistening ointment formula on vascular calcification and blood pressure of yin-deficiency and yang-hyperactivity type hypertension rat
1.1 animals
Healthy and clean SD rats (20 weeks old), female, with a body mass of 200-220 g and a body mass of 180-220 g, provided by the animal experiment center of Shanghai medical university. Adaptive breeding for 1 week at room temperature of about 23 deg.C and relative humidity of 40% -70%.
1.2 test drugs
The invention relates to a yin nourishing and jade moistening ointment formula: prepared as described in example 1. The preparation is administered by mixing with purified water.
The original yin-nourishing and jade-moistening ointment formula comprises: american ginseng 90 g, starwort root 60 g, vinegar processed bupleurum 90 g, fertile anemarrhena rhizome 60 g, guanhuangbai corktree bark 60 g, shrubby peach 90 g, dried rehmannia root and prepared rehmannia root 120 g respectively, cornus officinalis 100 g, wide curcuma root 90 g, finger citron 90 g, green calyx prunella 90 g, chinese rose 60 g, angelica root 120 g, red peony root and white peony root 100 g respectively, fried hemlock parsley 150 g, prepared nutgrass galingale rhizome 90 g, fried bitter orange 90 g, poria cocos 120 g, albizia bark 90 g, wild jujube seed 60 g, tuber fleeceflower 150 g, trichosanthes root 90 g, dendrobium 60 g, polygonatum 90 g, honey-fried licorice root 60 g, red jujube 100 g, walnut meat 100 g, lotus seed meat 100 g, wolfberry fruit 100 g and black sesame 100 g. The medicines are decocted in a thick mode, dregs are removed, and 400 g of donkey-hide gelatin, 250 g of white honey and 250 g of yellow wine are added into the thick juice to be melted and collected into paste. The preparation is prepared into solution when being administered.
Enalapril: approval document No.: national drug standard H20080059. Production enterprises: tianjin Tianshili pharmaceutical products, inc.
1.3 grouping and Molding
40 SD rats were randomly divided into 4 groups, including model group, inventive yin-nourishing and jade-moistening plaster formula group, former yin-nourishing and jade-moistening plaster formula group and enalapril group, each group containing 10 rats. All 4 groups were given molds.
A model building method for yin deficiency and yang excess type hypertension rats comprises the following steps: rats were fasted and kept without water for 12h, and placed in an artificial climate chamber (dry 40 ℃ and wet 32 ℃) for heat stress for 3 h. Preoperative abdominal cavity injection chloral hydrate (30 mg/kg) is anesthetized, the abdomen is upwards fixed on an operation table, local skin is disinfected, a knife is placed at a position of about 1.5cm below the xiphoid process along the abdominal midline, an abdominal muscle layer is cut, the right finger is inserted into the abdomen to search for the kidney, the left hand is matched with the body to gently extrude the kidney, gauze soaked by prepared normal saline is wrapped and fixed by hands, the left renal artery at the position close to the renal hilum on the left side is separated, a line is taken to cross from the lower part, the thickness level of the artery is compared, a proper thin line is selected and placed according to the trend of blood vessels, a transverse line is knotted, the thin line is taken out after ligation, the wound is recovered, and the operation table is disinfected by iodine. After the rat is raised for 4 weeks in a conventional manner, the molding condition is evaluated, and the blood pressure measurement shows that the blood pressure of the rat is increased by 22.6mmHg (3 kPa) and reaches a reference value of 135mmHg (18 kPa) or more.
The activity, mood, hair, diet, body temperature, etc. of the rats were observed at regular time every day, and the irritability level of the rats was observed and classified at 1 week (before administration) and 5 weeks (4 weeks) after the molding. Grade I (1) screaming and twitching while catching neck; level II (2 points) of irritability and biting when catching the neck; grade III (3), the tail is lifted, i.e. screaming and frightening, even people want to bite the tail or rats in the same cage frequently fight and bite the iron cage frequently. The case is not obvious, and is 0 grade (0 point). And eliminating the mould after grading if the mould is not successfully made. According to the fact that the appearance hair color becomes hard, the glossiness is reduced, the temperament is easy to irritate, the food intake and the water intake are increased, the model of yin deficiency and yang excess is determined to be successful. I.e. indicating that the molding was successful.
1.4 modes of administration
The model group is that the stomach is irrigated with 0.9 percent sodium chloride solution with the volume equal to that of the traditional Chinese medicine;
the invention relates to a yin-nourishing and jade-moistening paste formula which is prepared by feeding corresponding liquid medicine into stomach according to the dose of 10g crude drugs/(kg.d) -1, wherein the crude drugs are raw materials except sugar and yellow wine;
the original yin-nourishing and jade-moistening paste formula comprises that corresponding liquid medicine is given according to the dose of 10g crude drugs/(kg.d) -1 for intragastric administration, wherein the crude drugs are raw materials except sugar and yellow wine;
enalapril group, wherein the Enalapril is Enalapril 10mg/kg/d, dissolved in 0.9% sodium chloride solution with volume equal to that of the traditional Chinese medicine, and then administered to stomach;
rat tail artery blood pressure was measured before and after 1 treatment course (4 weeks) using a DSWY-1 rat tail artery blood pressure measuring device and blood pressure differences between groups were observed. Measuring the calcium content in the aorta smooth muscle cells, taking rat aorta, flushing the aorta with Hanks liquid to remove blood stain on the surface of the tissue, removing connective tissues, cutting blood vessels, scraping vascular endothelial cells, shearing the aorta into 0.5-1 mm & lt 3 & gt, flushing the Hanks liquid until the aorta is not turbid, sucking the Hanks liquid, adding a collagenase II solution with the volume fraction of 0.2, digesting the aorta at 37 ℃ for 15min, filtering the tissue without digestion, centrifuging the tissue at 1000r/min for 5min, removing supernatant, cleaning the Hanks liquid, adding a DMEM culture solution containing fetal calf serum with the volume fraction of 10 to prepare cell suspension, inoculating the cell suspension into a 24-hole culture plate for culture, taking out a cover glass of adherent PASMC after the cells are attached to the wall, adding a proper amount of Hanks liquid, carrying out warm bath at 37 ℃ for 10min, adding Furu-2/AM with the final concentration of 5mg/L, oscillating the cell suspension for 45min at 37 ℃, measuring the bovine serum albumin with the volume fraction of 0.2 albumin with Hanks liquid, rewarming the cell at 37 ℃, adding Furu-2 AM into a Furu-2/AM, and measuring the single-Ca-2 SMC in a fluorescence microscope in real-time.
The statistical method adopts SPSS10.0 medical statistical software package to perform statistical processing of data, and the measured data is expressed by (x +/-s); ANOAV analysis of variance is adopted, parallel homogeneity of variance tests are carried out, pairing t tests are adopted for the homogeneity of variance, and otherwise, t' tests are adopted; multiple comparisons were performed using analysis of variance. The difference is statistically significant when P is less than 0.05.
1.5 results:
compared differences among various groups of models before treatment of the change of the tail arterial blood pressure of rats, the yin-nourishing and jade-moistening plaster formula group, the original yin-nourishing and jade-moistening plaster formula group and the enalapril group have no statistical significance (P is more than 0.05);
after treatment, the blood pressure of the tail artery of rats in the yin-nourishing and jade cream formula group, the original yin-nourishing and jade cream formula group and the enalapril group of the invention are all obviously reduced (P is less than 0.05), wherein the blood pressure reduction range of the yin-nourishing and jade cream formula group is larger than that of the original yin-nourishing and jade cream formula group (P is less than 0.05) in the table 1)
TABLE 1 comparison of the blood pressure in the tail artery of rats (x. + -. S, mmHg)
Calcium content in aortic smooth muscle cells is measured in real time by a fluorescence microscopy, and calcium content in the rat aortic smooth muscle cells of the yin-nourishing and jade-moistening cream formula group, the original yin-nourishing and jade-moistening cream formula group and the enalapril group is reduced to different degrees (P is less than 0.05), wherein the calcium content of the yin-nourishing and jade-moistening cream formula group is reduced more than that of the original yin-nourishing and jade cream formula group (P is less than 0.05), and the calcium content is shown in table 2.
TABLE 2 comparison of calcium content in aortic smooth muscle cells (x. + -. S, nmol/L) of rats in each group
The above description is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, several modifications and additions can be made without departing from the method of the present invention, and these modifications and additions should also be regarded as the protection scope of the present invention.
Claims (2)
1. The yin nourishing and jade moistening ointment is characterized by being prepared from the following raw material medicines in parts by weight: 90 parts of American ginseng, 120 parts of angelica, 100 parts of herba epimedii, 90 parts of vinegar-processed radix bupleuri, 150 parts of poria alba, 60 parts of Chinese rose, 60 parts of starwort root, 90 parts of fat rhizoma anemarrhenae, 120 parts of radix rehmanniae, 120 parts of prepared rehmannia root, 90 parts of radix curcumae, 90 parts of tender rhizoma curculiginis, 100 parts of red paeony root, 100 parts of white paeony root, 90 parts of glossy privet fruit, 150 parts of light wheat, 150 parts of Huai wheat, 60 parts of fried golden cypress, 90 parts of shrubby peach stem, 100 parts of pulp of dogwood fruit, 90 parts of fingered citron slice, 90 parts of flos mume, 90 parts of prepared nutgrass galingale rhizome, 90 parts of fried fructus aurantii, 90 parts of cortex albiziae, 60 parts of spina date seed, 150 parts of tuber fleeceflower stem, 90 parts of mongolian snakegourd root, 150 parts of dendrobium, 90 parts of rhizoma polygonati, 60 parts of honey-fried licorice root, 90 parts of Chinese date, 90 parts of walnut meat, 90 parts of lotus seed pulp, 150 parts of donkey-hide gelatin, 150 parts of turtle shell glue, 60 parts of tortoise plastron glue, 250 parts of maltose, 250 parts of white honey and 250 parts of yellow rice wine.
2. The use of the yin-nourishing and jade-moistening paste according to claim 1 in the preparation of a medicament for treating yin-deficiency and yang-hyperactivity type hypertension.
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