CN114344433A - Yin-nourishing and jade-moistening ointment formula and application thereof - Google Patents
Yin-nourishing and jade-moistening ointment formula and application thereof Download PDFInfo
- Publication number
- CN114344433A CN114344433A CN202210147148.2A CN202210147148A CN114344433A CN 114344433 A CN114344433 A CN 114344433A CN 202210147148 A CN202210147148 A CN 202210147148A CN 114344433 A CN114344433 A CN 114344433A
- Authority
- CN
- China
- Prior art keywords
- parts
- root
- yin
- nourishing
- fried
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to a yin-nourishing and jade-moistening ointment formula which is prepared from the following raw material medicines in parts by weight: 90 parts of American ginseng, 130 parts of angelica sinensis, 90-110 parts of herba epimedii, 90 parts of vinegar radix bupleuri, 150 parts of white poria, 60 parts of China rose, 60 parts of starwort root, 90 parts of rhizoma anemarrhenae, 120 parts of radix rehmanniae recen, 120 parts of prepared rehmannia root, 90 parts of radix curcumae, 90 parts of tender rhizoma curculiginis, 100 parts of red paeony root, 100 parts of white paeony root, 90 parts of glossy privet fruit, 160 parts of light wheat, 150 parts of Huai wheat, 60 parts of fried golden cypress, 90 parts of shrubby peach, 100 parts of dogwood fruit, 90 parts of fingered citron slice, 90 parts of Prunus mume, 90 parts of prepared rhizoma cyperi, 90 parts of fried fructus aurantii, 90 parts of cortex albiziae, 60 parts of spina date seed, 160 parts of tuber fleeceflower stem, 90 parts of trichosanthes root, 150 parts of dendrobium, 90 parts of rhizoma polygonati, 60 parts of honey-fried licorice root, 90 parts of Chinese date, 90 parts of walnut meat and the like. The invention also provides the application of the yin-nourishing and jade-moistening ointment formula. The traditional Chinese medicine composition has the effects of nourishing yin, clearing heat, soothing liver, relieving depression, replenishing blood, activating blood, improving and treating yin deficiency constitution and qi depression constitution of perimenopausal women, and has a remarkable effect.
Description
Technical Field
The invention relates to the field of traditional Chinese medicines, and in particular relates to a yin-nourishing and jade-moistening ointment formula and application thereof.
Background
The traditional Chinese medicine health-preserving paste formula is a semi-fluid preparation prepared by repeatedly decocting traditional Chinese medicine decoction pieces according to the principle of traditional Chinese medicine, removing residues, taking juice, evaporating and concentrating, and adding sugar, honey or donkey-hide gelatin and the like, has good effects on weak and susceptible people, sub-health states, chronic diseases, special crowds such as children, women, old people and the like, and is increasingly widely applied in modern clinic.
In long-term clinical practice, the applicant uses a self-prepared yin-nourishing jade ointment formula to perform intervention treatment on perimenopausal women with yin-deficiency constitution and qi-stagnation constitution in winter seasons, and can remarkably improve symptom expression qi deficiency of perimenopausal women with yin-deficiency constitution and qi-stagnation constitution. The basic formula of the yin nourishing and jade moistening ointment formula comprises: american ginseng 90 g, starwort root 60 g, vinegar processed bupleurum 90 g, fertile anemarrhena 60 g, Guanhuangbai bark 60 g, shrunken peach 90 g, dried rehmannia root, prepared rehmannia root 120 g each, cornus officinalis 100 g, curcuma aromatica 90 g, finger citron 90 g, green calyx prune 90 g, Chinese rose 60 g, angelica root 120 g, red peony root, white peony root 100 g each, fried ligusticum wallichii 150 g, prepared cyperus tuber 90 g, fried bitter orange 90 g, poria cocos 120 g, albizia bark 90 g, wild jujube seed 60 g, tuber fleeceflower 150 g, trichosanthes root 90 g, dendrobium 60 g, polygonatum 90 g, honey-fried licorice root 60 g, red jujube 100 g, walnut meat 100 g, lotus seed meat 100 g, wolfberry 100 g and black sesame 100 g. The medicines are decocted in a thick mode, dregs are removed, and 400 g of donkey-hide gelatin, 250 g of white honey and 250 g of yellow wine are added into the thick juice to be melted and collected into paste.
In the later practical process, the applicant adjusts the medicine to obtain another prescription on the basis of earlier work, and animal experiments prove that the effect is more obvious.
Disclosure of Invention
The invention aims to provide a formula of jade paste for nourishing yin aiming at the defects in the prior art.
The invention further aims to provide application of the yin-nourishing and jade-moistening ointment formula.
In order to achieve the first purpose, the invention adopts the technical scheme that: the yin-nourishing and jade-moistening ointment formula is prepared from the following raw material medicines in parts by weight: 90 parts of American ginseng, 130 parts of angelica sinensis, 90-110 parts of herba epimedii, 90 parts of vinegar radix bupleuri, 150 parts of white poria, 60 parts of China rose, 60 parts of starwort root, 90 parts of rhizoma anemarrhenae, 120 parts of radix rehmanniae recen, 120 parts of prepared rehmannia root, 90 parts of radix curcumae, 90 parts of tender rhizoma curculiginis, 100 parts of red paeony root, 100 parts of white paeony root, 90 parts of glossy privet fruit, 160 parts of light wheat, 150 parts of Huai wheat, 60 parts of fried cortex phellodendri, 90 parts of shrubby peach, 100 parts of pulp of dogwood fruit, 90 parts of fingered citron slice, 90 parts of prunus mume, 90 parts of prepared rhizoma cyperi, 90 parts of fried fructus aurantii, 90 parts of cortex albiziae, 60 parts of spina date seed, 160 parts of tuber fleeceflower stem, 90 parts of trichosanthes root, 150 parts of dendrobium, 90 parts of rhizoma polygonati, 60 parts of honey-fried licorice root, 90 parts of Chinese date, 90 parts of meat, 90 parts of lotus seed pulp, 150 parts of donkey-hide gelatin, 60 parts of glue, 60 parts of tortoise-plastron glue, 250 parts of maltose, 250 parts of yellow wine.
Preferably, the yin nourishing and jade moistening ointment formula is prepared from the following raw material medicines in parts by weight: 90 parts of American ginseng, 115 parts of angelica sinensis, 125 parts of rhizoma epimedii, 95-105 parts of vinegar radix bupleuri, 150 parts of white poria, 60 parts of China rose, 60 parts of starwort root, 90 parts of rhizoma anemarrhenae, 120 parts of radix rehmanniae recen, 120 parts of prepared rehmannia root, 90 parts of radix curcumae, 90 parts of tender rhizoma curculiginis, 100 parts of red paeony root, 100 parts of white paeony root, 90 parts of glossy privet fruit, 155 parts of light wheat, 150 parts of Huai wheat, 60 parts of fried golden cypress, 90 parts of shrubby peach, 100 parts of dogwood fruit, 90 parts of fingered citron slice, 90 parts of prunus mume, 90 parts of prepared rhizoma cyperi, 90 parts of fried fructus aurantii, 90 parts of cortex albiziae, 60 parts of spina date seed, 145 parts of tuber fleeceflower stem, 90 parts of trichosanthes root, 150 parts of dendrobium, 90 parts of rhizoma polygonati, 60 parts of honey-fried licorice root, 90 parts of Chinese date, 90 parts of meat, 90 parts of lotus seed meat, 150 parts of donkey-hide gelatin, 60 parts of turtle shell glue, 60 parts of tortoise-plastron glue, 250 parts of maltose syrup, 250 parts of yellow rice wine.
More preferably, the yin nourishing and jade moistening ointment formula is prepared from the following raw material medicines in parts by weight: 90 parts of American ginseng, 120 parts of angelica, 100 parts of herba epimedii, 90 parts of vinegar radix bupleuri, 150 parts of white poria, 60 parts of Chinese rose, 60 parts of starwort root, 90 parts of fat rhizoma anemarrhenae, 120 parts of radix rehmanniae, 120 parts of prepared rehmannia root, 90 parts of wide radix curcumae, 90 parts of tender rhizoma curculiginis, 100 parts of red paeony root, 100 parts of white paeony root, 90 parts of glossy privet fruit, 150 parts of light wheat, 150 parts of Huai wheat, 60 parts of fried golden cypress, 90 parts of dried peach, 100 parts of pulp of dogwood fruit, 90 parts of fingered citron slice, 90 parts of flos Pruni mume, 90 parts of prepared nutgrass galingale rhizome, 90 parts of fried fructus aurantii, 90 parts of cortex albiziae, 60 parts of tuber fleeceflower stem, 150 parts of radix trichosanthis, 150 parts of dendrobium, 90 parts of rhizoma polygonati, 60 parts of honey-fried licorice, 90 parts of Chinese date, 90 parts of walnut pulp, 90 parts of lotus seed pulp, 150 parts of donkey-hide gelatin, 60 parts of turtle shell glue, 60 parts of tortoise plastron glue, 250 parts of maltose syrup, 250 parts of white rice wine and 250 parts of yellow rice wine.
In order to achieve the second object, the invention adopts the technical scheme that:
the application of the yin-nourishing jade cream formula in preparing food, health-care products or medicines for improving yin-deficiency constitution of perimenopausal women or qi depression constitution symptoms of perimenopausal women.
The invention has the advantages that:
1. the treatment principle of the invention is as follows: nourishing yin, clearing away heat, soothing liver, relieving depression, replenishing blood and promoting blood circulation
Compatibility of medicines: the yin nourishing and jade moistening ointment formula is prepared by reducing and cutting basic traditional Chinese medicine formulas of Dizhi pill, Erxian decoction, Xiaoyao powder, radix bupleuri and liver soothing powder and Zhibai Dihuang pill. In the prescription medication aspect, the prepared rehmannia root, the angelica, the donkey-hide gelatin, the turtle shell gelatin and the tortoise-plastron gelatin are used together, so that the blood and the yin are enriched, and the essence and the marrow are also enriched; the glossy privet fruit and the American ginseng have the effects of nourishing yin and enriching blood, promoting the production of body fluid and moistening dryness, while the American ginseng has the effects of clearing and nourishing qi and yin, and clearing heat and promoting the production of body fluid; fructus Corni has effects in nourishing liver and kidney, astringing and inducing astringency; tender Xian Mao and Xian Ling spleen warm kidney yang, tonify kidney essence, and have the actions of warming kidney yang and regulating Chong and ren meridians, and regulating yin from yang, they are monarch drugs.
In the recipe, liver-soothing and qi-regulating herbs are added, white peony root has the effects of liver softening, blood nourishing and yin astringing, and fried bitter orange, Chinese rose flower, fingered citron tablet, rose, vinegar-processed radix bupleuri, radix curcumae, flos cuprifoliae mume and prepared rhizoma cyperi are used for soothing the liver and relieving depression and also for relieving pain and regulating the middle warmer; trichosanthes root, dendrobium, and rhizoma polygonati nourish yin and clear heat; radix rehmanniae clears heat and cools blood; radix Paeoniae Rubra has effects of regulating menstruation and promoting blood circulation; the white poria cocos, spleen-a ministerial drugs and a ministerial drug for strengthening the spleen and tranquilization.
Meanwhile, radix Stellariae can clear and reduce deficiency heat, and rhizoma anemarrhenae and fried cortex phellodendri are used in mutual reinforcement to achieve the functions of clearing heat and purging fire, and nourishing yin and moistening dryness; the light wheat and the Huai wheat are matched for clearing deficiency heat and arresting sweating; flat peach and dry peach to promote the production of body fluid and stop sweating; cortex Albizziae, semen Ziziphi Spinosae and caulis Polygoni Multiflori are used as adjuvant drugs for tranquilizing mind.
Prepared licorice, Chinese date, walnut meat, lotus seed meat, maltose, white honey and yellow wine are used as guiding drugs for harmonizing the drugs in the recipe.
2. Animal experiments show that the yin-nourishing and jade-moistening ointment formula has obvious effects on vascular calcification and blood pressure of yin-deficiency and yang-hyperactivity type hypertensive rats and has obvious effects.
Detailed Description
The following provides a detailed description of specific embodiments of the present invention.
Example 1 preparation of a Yin-nourishing and Jade-moisturizing formula of the invention
90 parts of American ginseng, 120 parts of angelica sinensis, 100 parts of herba epimedii, 90 parts of vinegar radix bupleuri, 150 parts of white poria, 60 parts of Chinese rose, 60 parts of starwort root, 90 parts of fat rhizoma anemarrhenae, 120 parts of radix rehmanniae, 120 parts of prepared rehmannia root, 90 parts of wide radix curcumae, 90 parts of tender rhizoma curculiginis, 100 parts of red paeony root, 100 parts of white paeony root, 90 parts of glossy privet fruit, 150 parts of light wheat, 150 parts of Huai wheat, 60 parts of fried golden cypress, 90 parts of dried peach, 100 parts of pulp of dogwood fruit, 90 parts of fingered citron piece, 90 parts of flos Pruni mume, 90 parts of prepared nutgrass galingale rhizome, 90 parts of fried fructus aurantii, 90 parts of cortex albiziae, 60 parts of tuber fleeceflower stem, 150 parts of radix trichosanthis, 150 parts of dendrobe, 90 parts of rhizoma polygonati, 60 parts of honey-fried licorice, 90 parts of Chinese date, 90 parts of walnut meat, 90 parts of lotus seed meat, 60 parts of turtle shell glue and 60 parts of tortoise plastron glue, the concentrated decoction is obtained, dregs are removed, and decocted, 150 parts of donkey-hide glue, 250 parts of sugar, 250 parts of rice wine and 250 parts of honey are added into the concentrated decoction.
EXAMPLE 2 preparation of the Yin nourishing and moisturizing formula (II)
90 parts of American ginseng, 120 parts of angelica sinensis, 90 parts of herba epimedii, 90 parts of vinegar radix bupleuri, 150 parts of white poria, 60 parts of Chinese rose, 60 parts of starwort root, 90 parts of fat rhizoma anemarrhenae, 120 parts of radix rehmanniae, 120 parts of prepared rehmannia root, 90 parts of wide radix curcumae, 90 parts of tender rhizoma curculiginis, 100 parts of red paeony root, 100 parts of white paeony root, 90 parts of glossy privet fruit, 160 parts of light wheat, 150 parts of Huai wheat, 60 parts of fried golden cypress, 90 parts of shrubby peach, 100 parts of pulp of dogwood fruit, 90 parts of fingered citron piece, 90 parts of flos Pruni mume, 90 parts of prepared nutgrass galingale rhizome, 90 parts of fried fructus aurantii, 90 parts of cortex albiziae, 60 parts of tuber fleeceflower stem, 145 parts of radix trichosanthis, 150 parts of dendrobium, 90 parts of rhizoma polygonati, 60 parts of honey-fried licorice, 90 parts of Chinese date, 90 parts of walnut meat, 90 parts of lotus seed meat, 60 parts of turtle shell glue and 60 parts of tortoise plastron glue, the concentrated decoction is taken, the above medicines are deslagged and decocted, 150 parts of donkey-hide glue, 250 parts of sugar, 250 parts of rice wine and honey-melting paste are added.
EXAMPLE 3 preparation of the Yin nourishing and moisturizing formula of the invention
90 parts of American ginseng, 110 parts of angelica, 110 parts of herba epimedii, 90 parts of vinegar radix bupleuri, 150 parts of white poria, 60 parts of Chinese rose, 60 parts of starwort root, 90 parts of rhizoma anemarrhenae, 120 parts of radix rehmanniae, 120 parts of prepared rehmannia root, 90 parts of radix curcumae, 90 parts of tender rhizoma curculiginis, 100 parts of red paeony root, 100 parts of white paeony root, 90 parts of glossy privet fruit, 145 parts of light wheat, 150 parts of Huai wheat, 60 parts of fried golden cypress, 90 parts of dried peach, 100 parts of pulp of dogwood fruit, 90 parts of fingered citron slice, 90 parts of flos Pruni mume, 90 parts of prepared nutgrass galingale rhizome, 90 parts of fried fructus aurantii, 90 parts of cortex albiziae, 60 parts of tuber fleeceflower stem, 155 parts of radix trichosanthis, 150 parts of dendrobium, 90 parts of rhizoma polygonati, 60 parts of honey-fried licorice, 90 parts of Chinese date, 90 parts of walnut meat, 90 parts of lotus seed meat, 60 parts of turtle shell glue and 60 parts of tortoise plastron glue, the concentrated decoction is obtained, 150 parts of donkey-hide glue, 250 parts of maltose, 250 parts of yellow rice wine and honey-melting paste are added into the concentrated decoction.
Example 4 preparation of a Yin-nourishing and Jade-moisturizing formula (IV) of the invention
90 parts of American ginseng, 130 parts of angelica sinensis, 95 parts of herba epimedii, 90 parts of vinegar radix bupleuri, 150 parts of white poria, 60 parts of Chinese rose, 60 parts of starwort root, 90 parts of fat rhizoma anemarrhenae, 120 parts of radix rehmanniae, 120 parts of prepared rehmannia root, 90 parts of radix curcumae, 90 parts of tender rhizoma curculiginis, 100 parts of red paeony root, 100 parts of white paeony root, 90 parts of glossy privet fruit, 155 parts of light wheat, 150 parts of Huai wheat, 60 parts of fried golden cypress, 90 parts of dried peach, 100 parts of pulp of dogwood fruit, 90 parts of fingered citron slice, 90 parts of flos Pruni mume, 90 parts of prepared nutgrass galingale rhizome, 90 parts of fried fructus aurantii, 90 parts of cortex albiziae, 60 parts of tuber fleeceflower stem, 150 parts of radix trichosanthis, 150 parts of dendrobe, 90 parts of rhizoma polygonati, 60 parts of honey-fried licorice, 90 parts of Chinese date, 90 parts of walnut pulp, 90 parts of lotus seed pulp, 60 parts of turtle shell glue and 60 parts of tortoise plastron glue, the concentrated decoction is obtained, dregs are removed, and decocted, 150 parts of donkey-hide glue, 250 parts of sugar, 250 parts of rice wine and 250 parts of honey-melting paste are added into the concentrated decoction.
Example 5 preparation of a Yin-nourishing and Jade-moisturizing formula of the invention
90 parts of American ginseng, 115 parts of angelica sinensis, 105 parts of herba epimedii, 90 parts of vinegar radix bupleuri, 150 parts of white poria, 60 parts of Chinese rose, 60 parts of starwort root, 90 parts of rhizoma anemarrhenae, 120 parts of radix rehmanniae, 120 parts of prepared rehmannia root, 90 parts of radix curcumae, 90 parts of tender rhizoma curculiginis, 100 parts of red paeony root, 100 parts of white paeony root, 90 parts of glossy privet fruit, 150 parts of light wheat, 150 parts of Huai wheat, 60 parts of fried golden cypress, 90 parts of dried peach, 100 parts of pulp of dogwood fruit, 90 parts of fingered citron slice, 90 parts of flos Pruni mume, 90 parts of prepared nutgrass galingale rhizome, 90 parts of fried fructus aurantii, 90 parts of cortex albiziae, 60 parts of tuber fleeceflower stem, 140 parts of radix trichosanthis, 150 parts of dendrobium, 90 parts of rhizoma polygonati, 60 parts of honey-fried licorice, 90 parts of Chinese date, 90 parts of walnut meat, 90 parts of lotus seed meat, 60 parts of turtle shell glue and 60 parts of tortoise plastron glue, the concentrated decoction is obtained, dregs are removed, and decocted, 150 parts of donkey-hide glue, 250 parts of sugar, 250 parts of rice wine and honey are added into the concentrated decoction.
EXAMPLE 6 preparation of the Yin nourishing and moisturizing formula (VI)
90 parts of American ginseng, 125 parts of angelica sinensis, 100 parts of herba epimedii, 90 parts of vinegar radix bupleuri, 150 parts of white poria, 60 parts of Chinese rose, 60 parts of starwort root, 90 parts of rhizoma anemarrhenae, 120 parts of radix rehmanniae, 120 parts of prepared rehmannia root, 90 parts of radix curcumae, 90 parts of tender rhizoma curculiginis, 100 parts of red paeony root, 100 parts of white paeony root, 90 parts of glossy privet fruit, 140 parts of light wheat, 150 parts of Huai wheat, 60 parts of fried golden cypress, 90 parts of dried peach, 100 parts of pulp of dogwood fruit, 90 parts of fingered citron slice, 90 parts of flos Pruni mume, 90 parts of prepared nutgrass galingale rhizome, 90 parts of fried fructus aurantii, 90 parts of cortex albiziae, 60 parts of tuber fleeceflower stem, 160 parts of radix trichosanthis, 150 parts of dendrobium, 90 parts of rhizoma polygonati, 60 parts of honey-fried licorice, 90 parts of Chinese date, 90 parts of walnut pulp, 90 parts of lotus seed pulp, 60 parts of turtle shell glue and 60 parts of tortoise plastron glue, the concentrated decoction is obtained, dregs are removed, and decocted, 150 parts of donkey-hide glue, 250 parts of sugar, 250 parts of rice wine and honey are added into the concentrated decoction.
Example 7 preparation of a formula of yin-nourishing and jade cream of the invention
90 parts of American ginseng, 120 parts of angelica, 110 parts of herba epimedii, 90 parts of vinegar radix bupleuri, 150 parts of white poria, 60 parts of Chinese rose, 60 parts of starwort root, 90 parts of rhizoma anemarrhenae, 120 parts of radix rehmanniae, 120 parts of prepared rehmannia root, 90 parts of radix curcumae, 90 parts of tender rhizoma curculiginis, 100 parts of red paeony root, 100 parts of white paeony root, 90 parts of glossy privet fruit, 145 parts of light wheat, 150 parts of Huai wheat, 60 parts of fried golden cypress, 90 parts of dried peach, 100 parts of pulp of dogwood fruit, 90 parts of fingered citron slice, 90 parts of flos Pruni mume, 90 parts of prepared nutgrass galingale rhizome, 90 parts of fried fructus aurantii, 90 parts of cortex albiziae, 60 parts of tuber fleeceflower stem, 155 parts of radix trichosanthis, 150 parts of dendrobium, 90 parts of rhizoma polygonati, 60 parts of honey-fried licorice, 90 parts of Chinese date, 90 parts of walnut meat, 90 parts of lotus seed meat, 60 parts of turtle shell glue and 60 parts of tortoise plastron glue, the concentrated decoction is obtained, and the residue is removed and decocted, 150 parts of donkey-hide glue, 250 parts of honey paste are added into the concentrated decoction.
EXAMPLE 8 preparation of the Yin nourishing and moisturizing formula (VIII)
90 parts of American ginseng, 110 parts of angelica, 95 parts of herba epimedii, 90 parts of vinegar radix bupleuri, 150 parts of white poria, 60 parts of Chinese rose, 60 parts of starwort root, 90 parts of rhizoma anemarrhenae, 120 parts of radix rehmanniae, 120 parts of prepared rehmannia root, 90 parts of radix curcumae, 90 parts of tender rhizoma curculiginis, 100 parts of red paeony root, 100 parts of white paeony root, 90 parts of glossy privet fruit, 145 parts of fructus aurantii, 150 parts of Huai wheat, 60 parts of fried golden cypress, 90 parts of dried peach, 100 parts of pulp of dogwood fruit, 90 parts of fingered citron slice, 90 parts of flos Pruni mume, 90 parts of prepared nutgrass galingale rhizome, 90 parts of fried fructus aurantii, 90 parts of cortex albiziae, 60 parts of tuber fleeceflower stem, 150 parts of radix trichosanthis, 150 parts of dendrobe, 90 parts of rhizoma polygonati, 60 parts of honey-fried licorice, 90 parts of Chinese date, 90 parts of walnut pulp, 90 parts of lotus seed pulp, 60 parts of turtle shell glue and 60 parts of tortoise plastron glue, the concentrated decoction is subjected to deslagging and honey melting, and 150 parts of donkey-hide glue, 250 parts of maltose syrup and yellow rice wine are added into the concentrated decoction.
Example 9 preparation of a Yin-nourishing and Jade-moisturizing formula of the invention (nine)
90 parts of American ginseng, 130 parts of angelica sinensis, 105 parts of herba epimedii, 90 parts of vinegar radix bupleuri, 150 parts of white poria, 60 parts of Chinese rose, 60 parts of starwort root, 90 parts of rhizoma anemarrhenae, 120 parts of radix rehmanniae, 120 parts of prepared rehmannia root, 90 parts of radix curcumae, 90 parts of tender rhizoma curculiginis, 100 parts of red paeony root, 100 parts of white paeony root, 90 parts of glossy privet fruit, 150 parts of light wheat, 150 parts of Huai wheat, 60 parts of fried golden cypress, 90 parts of dried peach, 100 parts of pulp of dogwood fruit, 90 parts of fingered citron slice, 90 parts of flos Pruni mume, 90 parts of prepared nutgrass galingale rhizome, 90 parts of fried fructus aurantii, 90 parts of cortex albiziae, 60 parts of tuber fleeceflower stem, 140 parts of radix trichosanthis, 150 parts of dendrobium, 90 parts of rhizoma polygonati, 60 parts of honey-fried licorice, 90 parts of Chinese date, 90 parts of walnut pulp, 90 parts of lotus seed pulp, 60 parts of turtle shell glue and 60 parts of tortoise plastron glue, the concentrated decoction is obtained, dregs are removed, and decocted, 150 parts of donkey-hide glue, 250 parts of sugar, 250 parts of rice wine and honey are added into the concentrated decoction.
Example 10 preparation of a Yin-nourishing and Jade-moisturizing formulation of the invention (ten)
90 parts of American ginseng, 115 parts of angelica, 100 parts of herba epimedii, 90 parts of vinegar radix bupleuri, 150 parts of white poria, 60 parts of Chinese rose, 60 parts of starwort root, 90 parts of rhizoma anemarrhenae, 120 parts of radix rehmanniae, 120 parts of prepared rehmannia root, 90 parts of radix curcumae, 90 parts of tender rhizoma curculiginis, 100 parts of red paeony root, 100 parts of white paeony root, 90 parts of glossy privet fruit, 140 parts of light wheat, 150 parts of Huai wheat, 60 parts of fried golden cypress, 90 parts of dried peach, 100 parts of pulp of dogwood fruit, 90 parts of fingered citron slice, 90 parts of flos Pruni mume, 90 parts of prepared nutgrass galingale rhizome, 90 parts of fried fructus aurantii, 90 parts of cortex albiziae, 60 parts of tuber fleeceflower stem 160 parts of root, 90 parts of mongolian snakegourd root, 150 parts of dendrobium, 90 parts of rhizoma polygonati, 60 parts of honey-fried licorice, 90 parts of Chinese date, 90 parts of walnut meat, 90 parts of lotus seed meat, 60 parts of turtle shell glue and 60 parts of tortoise plastron glue, the concentrated decoction is taken, dregs are removed, decocted, 150 parts of donkey-hide glue, 250 parts of sugar, 250 parts of rice wine and honey is melted paste.
Example 11 preparation of a Yin-nourishing and Jade-moisturizing formulation of the invention (eleven)
90 parts of American ginseng, 125 parts of angelica sinensis, 90 parts of herba epimedii, 90 parts of vinegar radix bupleuri, 150 parts of white poria, 60 parts of Chinese rose, 60 parts of starwort root, 90 parts of fat rhizoma anemarrhenae, 120 parts of radix rehmanniae, 120 parts of prepared rehmannia root, 90 parts of wide radix curcumae, 90 parts of tender rhizoma curculiginis, 100 parts of red paeony root, 100 parts of white paeony root, 90 parts of glossy privet fruit, 160 parts of light wheat, 150 parts of Huai wheat, 60 parts of fried golden cypress, 90 parts of shrubby peach, 100 parts of pulp of dogwood fruit, 90 parts of fingered citron piece, 90 parts of flos Pruni mume, 90 parts of prepared nutgrass galingale rhizome, 90 parts of fried fructus aurantii, 90 parts of cortex albiziae, 60 parts of tuber fleeceflower stem, 145 parts of radix trichosanthis, 150 parts of dendrobium, 90 parts of rhizoma polygonati, 60 parts of honey-fried licorice, 90 parts of Chinese date, 90 parts of walnut meat, 90 parts of lotus seed meat, 60 parts of turtle shell glue and 60 parts of tortoise plastron glue, the concentrated decoction is taken, the above medicines are deslagged and decocted, 150 parts of donkey-hide glue, 250 parts of sugar, 250 parts of rice wine and honey-melting paste are added.
Example 12
Experimental study on influence of yin-nourishing and jade-moistening ointment formula on vascular calcification and blood pressure of yin-deficiency and yang-hyperactivity type hypertension rat
1.1 animals
Healthy and clean SD rats (20 weeks old), female, with a body mass of 200-220 g and a body mass of 180-220 g, provided by the animal experiment center of Shanghai medical university. Adaptive feeding for 1 week at room temperature of about 23 deg.C and relative humidity of 40-70%.
1.2 test drugs
The invention relates to a yin nourishing and jade moistening ointment formula: prepared as described in example 1. The preparation is administered by mixing with purified water.
The original yin-nourishing and jade-moistening ointment formula comprises: american ginseng 90 g, starwort root 60 g, vinegar processed bupleurum 90 g, fertile anemarrhena 60 g, Guanhuangbai bark 60 g, shrunken peach 90 g, dried rehmannia root, prepared rehmannia root 120 g each, cornus officinalis 100 g, curcuma aromatica 90 g, finger citron 90 g, green calyx prune 90 g, Chinese rose 60 g, angelica root 120 g, red peony root, white peony root 100 g each, fried ligusticum wallichii 150 g, prepared cyperus tuber 90 g, fried bitter orange 90 g, poria cocos 120 g, albizia bark 90 g, wild jujube seed 60 g, tuber fleeceflower 150 g, trichosanthes root 90 g, dendrobium 60 g, polygonatum 90 g, honey-fried licorice root 60 g, red jujube 100 g, walnut meat 100 g, lotus seed meat 100 g, wolfberry 100 g and black sesame 100 g. The medicines are decocted in a thick mode, dregs are removed, and 400 g of donkey-hide gelatin, 250 g of white honey and 250 g of yellow wine are added into the thick juice to be melted and collected into paste. The preparation is prepared into solution when being administered.
Enalapril: approval document No.: national drug standard H20080059. Production enterprises: tianjin Tianshili pharmaceutical products, Inc.
1.3 grouping and Molding
40 SD rats were randomly divided into 4 groups, including model group, inventive yin-nourishing and jade-moistening plaster formula group, former yin-nourishing and jade-moistening plaster formula group and enalapril group, each group containing 10 rats. All 4 groups were given for molding.
A model building method for yin deficiency and yang excess type hypertension rats comprises the following steps: rats were fasted and kept without water for 12h, and placed in an artificial climate chamber (dry 40 ℃ and wet 32 ℃) for heat stress for 3 h. Preoperative abdominal cavity injection chloral hydrate (30mg/kg) is anesthetized, the abdomen is upwards fixed on an operation table, local skin is disinfected, a knife is placed at a position of about 1.5cm below the xiphoid process along the abdominal midline, an abdominal muscle layer is cut, the right finger is inserted into the abdomen to search for the kidney, the left hand is matched with the body to gently extrude the kidney, gauze soaked by prepared normal saline is wrapped and fixed by hands, the left renal artery at the position close to the renal hilum on the left side is separated, a line is taken to cross from the lower part, the thickness level of the artery is compared, a proper thin line is selected and placed according to the trend of blood vessels, a transverse line is knotted, the thin line is taken out after ligation, the wound is recovered, and the operation table is disinfected by iodine. After the rat is raised for 4 weeks in a conventional manner, the molding condition is evaluated, and the blood pressure measurement shows that the blood pressure of the rat is increased by 22.6mmHg (3kPa) and reaches a reference value of 135mmHg (18kPa) or more.
The activity, mood, hair, diet, body temperature, etc. of the rats were observed at regular time every day, and the irritability level of the rats was observed and classified at 1 week (before administration) and 5 weeks (4 weeks) after the molding. Grade I (1) screaming and twitching while catching neck; level II (2 points) of irritability and biting when catching the neck; grade III (3), the tail is lifted, i.e. screaming and frightening, even people want to bite the tail or rats in the same cage frequently fight and bite the iron cage frequently. The above case is not obvious and is 0 grade (0 point). And eliminating the mould after grading if the mould is not successfully made. According to the fact that the appearance hair color becomes hard, the glossiness is reduced, the temperament is easy to irritate, the food intake and the water intake are increased, the model of yin deficiency and yang excess is determined to be successful. I.e. indicating that the molding was successful.
1.4 modes of administration
The model group is that the stomach is irrigated with 0.9 percent sodium chloride solution with the volume equal to that of the traditional Chinese medicine;
the invention relates to a yin-nourishing and jade-moistening paste formula which is prepared by feeding corresponding liquid medicine into stomach according to the dose of 10g crude drugs/(kg.d) -1, wherein the crude drugs are raw materials except sugar and yellow wine;
the original Yin nourishing and Jade moistening ointment formula comprises the following steps of administering corresponding liquid medicine for intragastric administration according to the dose of 10g crude drugs/(kg. d) -1, wherein the crude drugs are raw materials except sugar and yellow wine;
enalapril group, wherein the Enalapril is Enalapril 10mg/kg/d, dissolved in 0.9% sodium chloride solution with volume equal to that of the traditional Chinese medicine, and then administered to stomach;
rat tail artery blood pressure was measured before and after 1 treatment course (4 weeks) using a DSWY-1 rat tail artery blood pressure measuring device and blood pressure differences between groups were observed. Measuring calcium content in aortic smooth muscle cells, washing rat aorta with Hanks solution to remove blood stain on the surface of tissue, removing connective tissue, cutting blood vessel, scraping vascular endothelial cells, cutting into 3 mm with size of 0.5-1 mm, washing Hanks solution until the solution is not turbid, sucking out Hanks solution, adding collagenase II solution with volume fraction of 0.2, digesting for 15min at 37 ℃, filtering to remove undigested tissue, centrifuging for 5min at 1000r/min, removing supernatant, washing with Hanks solution, adding DMEM culture solution containing fetal calf serum with volume fraction of 10 to prepare cell suspension, inoculating into a 24-hole culture plate for culture, taking out cover glass of adherent PASMC after cell adherence, adding appropriate Hanks solution, bathing for 10min at 37 ℃, adding Furu-2/AM with final concentration of 5mg/L, shaking for 45min at 37 ℃, washing with Hanks solution of bovine serum albumin with volume fraction of 0.2 for 2 times, and (3) rewarming for 10min at 37 ℃ before measurement, putting the PASMC loaded with Furu-2/AM into a measuring pool, adding D-Hanks liquid, selecting single cells, and performing real-time measurement on Ca by using a fluorescence microscopy technology.
The statistical method adopts SPSS10.0 medical statistical software package to perform statistical processing of data, and the measured data is expressed by (x +/-s); ANOAV analysis of variance is adopted, parallel homogeneity of variance tests are carried out, pairing t tests are adopted for the homogeneity of variance, and otherwise, t' tests are adopted; multiple comparisons were performed using analysis of variance. The difference is statistically significant when P is less than 0.05.
1.5 results:
compared differences among various groups of models before treatment of the change of the tail arterial blood pressure of rats, the yin-nourishing and jade-moistening plaster formula group, the original yin-nourishing and jade-moistening plaster formula group and the enalapril group have no statistical significance (P is more than 0.05);
after treatment, the blood pressure of the tail artery of rats in the yin-nourishing and jade cream formula group, the original yin-nourishing and jade cream formula group and the enalapril group of the invention are all obviously reduced (P is less than 0.05), wherein the blood pressure reduction range of the yin-nourishing and jade cream formula group is larger than that of the original yin-nourishing and jade cream formula group (P is less than 0.05) in the table 1)
TABLE 1 comparison of the blood pressure in the tail artery of rats (x. + -. s, mmHg)
Calcium content in aortic smooth muscle cells is measured in real time by a fluorescence microscopy, and calcium content in the rat aortic smooth muscle cells of the yin-nourishing and jade-moistening cream formula group, the original yin-nourishing and jade-moistening cream formula group and the enalapril group is reduced to different degrees (P is less than 0.05), wherein the calcium content of the yin-nourishing and jade-moistening cream formula group is reduced more than that of the original yin-nourishing and jade cream formula group (P is less than 0.05), and the calcium content is shown in table 2.
TABLE 2 comparison of calcium content in aortic smooth muscle cells (x. + -. s, nmol/L) of rats in each group
The above description is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, several modifications and additions can be made without departing from the method of the present invention, and these modifications and additions should also be regarded as the protection scope of the present invention.
Claims (4)
1. The yin-nourishing and jade-moistening ointment formula is characterized by being prepared from the following raw material medicines in parts by weight: 90 parts of American ginseng, 130 parts of angelica sinensis, 90-110 parts of herba epimedii, 90 parts of vinegar radix bupleuri, 150 parts of white poria, 60 parts of China rose, 60 parts of starwort root, 90 parts of rhizoma anemarrhenae, 120 parts of radix rehmanniae recen, 120 parts of prepared rehmannia root, 90 parts of radix curcumae, 90 parts of tender rhizoma curculiginis, 100 parts of red paeony root, 100 parts of white paeony root, 90 parts of glossy privet fruit, 160 parts of light wheat, 150 parts of Huai wheat, 60 parts of fried cortex phellodendri, 90 parts of shrubby peach, 100 parts of pulp of dogwood fruit, 90 parts of fingered citron slice, 90 parts of prunus mume, 90 parts of prepared rhizoma cyperi, 90 parts of fried fructus aurantii, 90 parts of cortex albiziae, 60 parts of spina date seed, 160 parts of tuber fleeceflower stem, 90 parts of trichosanthes root, 150 parts of dendrobium, 90 parts of rhizoma polygonati, 60 parts of honey-fried licorice root, 90 parts of Chinese date, 90 parts of meat, 90 parts of lotus seed pulp, 150 parts of donkey-hide gelatin, 60 parts of glue, 60 parts of tortoise-plastron glue, 250 parts of maltose, 250 parts of yellow wine.
2. The yin nourishing and jade nourishing paste formula according to claim 1, which is prepared from the following raw material medicines in parts by weight: 90 parts of American ginseng, 115 parts of angelica sinensis, 125 parts of rhizoma epimedii, 95-105 parts of vinegar radix bupleuri, 150 parts of white poria, 60 parts of China rose, 60 parts of starwort root, 90 parts of rhizoma anemarrhenae, 120 parts of radix rehmanniae recen, 120 parts of prepared rehmannia root, 90 parts of radix curcumae, 90 parts of tender rhizoma curculiginis, 100 parts of red paeony root, 100 parts of white paeony root, 90 parts of glossy privet fruit, 155 parts of light wheat, 150 parts of Huai wheat, 60 parts of fried golden cypress, 90 parts of shrubby peach, 100 parts of dogwood fruit, 90 parts of fingered citron slice, 90 parts of prunus mume, 90 parts of prepared rhizoma cyperi, 90 parts of fried fructus aurantii, 90 parts of cortex albiziae, 60 parts of spina date seed, 145 parts of tuber fleeceflower stem, 90 parts of trichosanthes root, 150 parts of dendrobium, 90 parts of rhizoma polygonati, 60 parts of honey-fried licorice root, 90 parts of Chinese date, 90 parts of meat, 90 parts of lotus seed meat, 150 parts of donkey-hide gelatin, 60 parts of turtle shell glue, 60 parts of tortoise-plastron glue, 250 parts of maltose syrup, 250 parts of yellow rice wine.
3. The yin nourishing and jade nourishing paste formula according to claim 2, which is characterized by being prepared from the following raw material medicines in parts by weight: 90 parts of American ginseng, 120 parts of angelica, 100 parts of herba epimedii, 90 parts of vinegar radix bupleuri, 150 parts of white poria, 60 parts of Chinese rose, 60 parts of starwort root, 90 parts of fat rhizoma anemarrhenae, 120 parts of radix rehmanniae, 120 parts of prepared rehmannia root, 90 parts of wide radix curcumae, 90 parts of tender rhizoma curculiginis, 100 parts of red paeony root, 100 parts of white paeony root, 90 parts of glossy privet fruit, 150 parts of light wheat, 150 parts of Huai wheat, 60 parts of fried golden cypress, 90 parts of dried peach, 100 parts of pulp of dogwood fruit, 90 parts of fingered citron slice, 90 parts of flos Pruni mume, 90 parts of prepared nutgrass galingale rhizome, 90 parts of fried fructus aurantii, 90 parts of cortex albiziae, 60 parts of tuber fleeceflower stem, 150 parts of radix trichosanthis, 150 parts of dendrobium, 90 parts of rhizoma polygonati, 60 parts of honey-fried licorice, 90 parts of Chinese date, 90 parts of walnut pulp, 90 parts of lotus seed pulp, 150 parts of donkey-hide gelatin, 60 parts of turtle shell glue, 60 parts of tortoise plastron glue, 250 parts of maltose syrup, 250 parts of white rice wine and 250 parts of yellow rice wine.
4. The use of the yin-nourishing jade cream formulation of claims 1-3 in the preparation of a food, health product, or medicament for improving or treating a yin-deficiency condition or a qi-stagnation condition in a perimenopausal female.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210147148.2A CN114344433B (en) | 2022-02-17 | 2022-02-17 | Yin-nourishing and jade-moistening ointment formula and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210147148.2A CN114344433B (en) | 2022-02-17 | 2022-02-17 | Yin-nourishing and jade-moistening ointment formula and application thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN114344433A true CN114344433A (en) | 2022-04-15 |
| CN114344433B CN114344433B (en) | 2023-04-07 |
Family
ID=81093719
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202210147148.2A Active CN114344433B (en) | 2022-02-17 | 2022-02-17 | Yin-nourishing and jade-moistening ointment formula and application thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN114344433B (en) |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112717081A (en) * | 2021-02-23 | 2021-04-30 | 上海中医药大学附属曙光医院 | Blood-activating face-beautifying cream formula and application thereof |
-
2022
- 2022-02-17 CN CN202210147148.2A patent/CN114344433B/en active Active
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112717081A (en) * | 2021-02-23 | 2021-04-30 | 上海中医药大学附属曙光医院 | Blood-activating face-beautifying cream formula and application thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN114344433B (en) | 2023-04-07 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| CN112915181B (en) | Qi-tonifying and vitality-restoring cream formula and application thereof | |
| CN103690784A (en) | Traditional Chinese medicinal composition for treating diabetic nephropathy combined hypertensive nephropathy and preparation method thereof | |
| CN115779064B (en) | Radix astragali strengthening square, preparation and application thereof | |
| CN104666896A (en) | Orally-taken medicine for treating alopecia seborrhoeica and preparation method for orally-taken medicine | |
| CN101249255B (en) | Proprietary Chinese medicine for curing children's cough and method of preparing the same | |
| CN104922448A (en) | Traditional Chinese medicine composition for treating fundus hemorrhage and application thereof | |
| CN114344433B (en) | Yin-nourishing and jade-moistening ointment formula and application thereof | |
| CN112717068B (en) | Traditional Chinese medicine composition for treating chronic fatigue syndrome and application thereof | |
| CN107198727A (en) | A kind of pharmaceutical composition of beautifying face and moistering lotion promoting blood circulation for regulating menstruation and preparation method thereof | |
| CN103356870B (en) | Traditional Chinese medicinal preparation for treating postpartum hypogalactia, and preparation method thereof | |
| CN106692589A (en) | Deer foetus semifluid extract and preparation process thereof | |
| CN105362630A (en) | Climacteric syndrome treatment pharmaceutical composition and preparation method thereof | |
| CN104371892A (en) | Fleece-flower root hair-blacking traditional Chinese medicine wine and preparation method thereof | |
| CN104056017A (en) | Traditional Chinese medicine composition for treating rheumatism and preparation method thereof | |
| CN104435962A (en) | Pharmaceutical composition for treating dyspeptic diarrhea of piglets and preparation method thereof | |
| CN105902867B (en) | A herbal composition for reducing hypertension, hyperglycemia and hyperlipidemia, and its preparation method | |
| CN102764383B (en) | Nipple care solution for treating postpartum cracked nipple | |
| CN104096073A (en) | Traditional Chinese medicine composition for treating male infertility and preparation method for same | |
| CN114432410B (en) | Blood circulation promoting and stasis removing paste formula and application thereof | |
| CN105998532A (en) | Preparation method for traditional Chinese medicine for treating Qi-stagnancy and blood stasis painful heel and composition of traditional Chinese medicine | |
| CN106539007A (en) | A kind of medicated diet cake formulation of enhancing immunity | |
| CN101934046A (en) | Semifluid extract of deer foetus and preparation method thereof | |
| CN1188162C (en) | Method for preparing Gongjinle medicinal liquor for treating tracheitis | |
| CN106728640A (en) | It is a kind of to treat the Chinese medicine composition that irregular menstruation promotes pregnancy | |
| CN105582379A (en) | Traditional Chinese medicine composition for treating liver-stomach disharmony and preparation method of traditional Chinese medicine composition |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant |