CN106692589A - Deer foetus semifluid extract and preparation process thereof - Google Patents

Deer foetus semifluid extract and preparation process thereof Download PDF

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Publication number
CN106692589A
CN106692589A CN201710039445.4A CN201710039445A CN106692589A CN 106692589 A CN106692589 A CN 106692589A CN 201710039445 A CN201710039445 A CN 201710039445A CN 106692589 A CN106692589 A CN 106692589A
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parts
deer
foetus
root
semifluid extract
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王雨千
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Fenghua Sika Deer Breeding Professional Cooperatives
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Fenghua Sika Deer Breeding Professional Cooperatives
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Priority to CN201710039445.4A priority Critical patent/CN106692589A/en
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    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/32Bones; Osteocytes; Osteoblasts; Tendons; Tenocytes; Teeth; Odontoblasts; Cartilage; Chondrocytes; Synovial membrane
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    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/36Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
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    • A61K2236/30Extraction of the material
    • A61K2236/33Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction

Abstract

The invention discloses a deer foetus semifluid extract and a preparation process thereof. The technical scheme is as follows: the deer foetus semifluid extract is composed of the following components in parts by mass: deer foetus powder, pilose deer horn, radix rehmanniae preparata, motherwort, red ginseng, radix salviae miltiorrhizae, angelica, wild jujube seed, radix saussureae lappae, yerbadetajo, corydalis tuber, radish seed, fennel, ginger, Mangnolia officinalis, tuckahoe, Bighead Atractylodes Rhizome, white peony root, rhizoma cyperi, sophora japonica, licorice root, cinnamon, Salvia japonica, silybum marianum, sesame, kudzu root, dried orange peel, chicken's gizzard-membrane, rabdosia lophanthide, donkey-hide gelatin and auxiliary aids. In the presence of the pure traditional Chinese medicine components, the deer foetus semifluid extract has a certain deterioration inhibition effect.

Description

A kind of semifluid extract of deer foetus and its preparation technology
Technical field
The present invention relates to health care preparation, more particularly to a kind of semifluid extract of deer foetus and its preparation technology.
Background technology
Deer tire is the tire of animal in deer family, is a kind of rare Chinese medicine, and history, biology are taken in China's existing centuries Medical research shows, containing rich in protein, polypeptide, amino acid, nucleic acid, vitamin etc. in deer tire and abundant hormone, Vitamin and enzyme, with enhance immunity, anti-aging, improve the effect such as hypoxia-bearing capability, are prepared by primary raw material of deer tire Into semifluid extract of deer foetus, with benefiting qi and nourishing blood, menstruation regulating cold dispelling, tonifying kidney and benefiting sperm is a kind of ideal immune tune the effects such as enriching yin beauty treatment Section agent and nutrient and healthcare products, are made generally in paste and take.
A kind of semifluid extract of deer foetus as disclosed in Publication No. CN1850226A and preparation method thereof, the raw material composition of the semifluid extract of deer foetus And weight proportion is:120~190 parts of deer tires, 17.5~35 parts of pilose antlers, 17.5~35 parts of deer bones, 17.5~35 parts of deer skin glues, 5~15 parts of motherworts, 5~10 parts of fruit of glossy privets, 5~10 parts of red ginsengs, 5~10 parts of white ginsengs, 5~15 parts of deer's tails, 5~10 parts of bighead atractylodes rhizomes, 5 ~10 portions of root of herbaceous peonys, 5~15 parts of Radix Angelicae Sinensis, 5~15 parts of Ligusticum wallichiis, 5~15 parts of prepared rhizomes of rehmannia, 5~15 portions of Radix Glycyrrhizaes, 5~10 parts of Poria cocos, 5~ 15 parts of rhizoma cyperis, 5~10 parts of corydalis tubers, 5~15 parts of fennel seeds, 5~15 parts of teasel roots, 5~10 parts of cattail pollens and 70~105 parts of brown sugar systems Into.
This kind of semifluid extract of deer foetus has treatment blood deficiency chlorosis, has a dizzy spell, and palpitation and insomnia, the deficiency of blood, irregular menstruation, uterine bleeding is lost blood, Waist soreness, insomnia, forgetful, night sweat, anoxic, depressed effect is pure Chinese medicine composition yet with antlet product, without anti-corrosion Agent, therefore its holding time is shorter, it is apt to deteriorate, influence the health-care effect of semifluid extract of deer foetus.
The content of the invention
First purpose of the invention is to provide a kind of semifluid extract of deer foetus, by Chinese medicine preparation make the semifluid extract of deer foetus with certain Antiseptic effect, is unlikely to deteriorate.
Above-mentioned technical purpose of the invention technical scheme is that:
A kind of semifluid extract of deer foetus, the semifluid extract of deer foetus following components is constituted, and the mass fraction of each component and each component is:Deer tire powder 100~ 200 parts, 5~10 parts of pilose antler, 5~10 parts of prepared rhizome of rehmannia, 5~10 parts of motherwort, 5~10 parts of red ginseng, 5~10 parts of the red sage root, Radix Angelicae Sinensis 5~ 10 parts, it is 5~10 parts of spina date seed, 5~10 parts of Aplotaxis auriculata, 5~10 parts of eclipta, 5~10 parts of corydalis tuber, 5~10 parts of radish seed, small 5~10 parts of fennel, 5~10 parts of stir-baked CORTEX MAGNOLIAE OFFICINALIS with rhizoma zingiberis recens juice, 5~10 parts of Poria cocos, 5~10 parts of the bighead atractylodes rhizome, 5~10 parts of the root of herbaceous peony, 5~10 parts of rhizoma cyperi, Chinese scholartree 5~10 parts of rice, 5~10 parts of Radix Glycyrrhizae, 5~10 parts of Chinese cassia tree, 5~10 parts of Salvia japonica, 5~10 parts of milk thistle, 5~10 parts of sesame, Pueraria lobota 5~10 parts of root, 5~10 parts of dried orange peel, 5~10 parts of the membrane of a chicken's gizzard, 5~10 parts of rabdosia lophanthide, 80~120 parts of donkey-hide gelatin, auxiliary material auxiliary agent 1000 ~2000 parts.
By using above-mentioned technical proposal, deer tire powder be applied to have improve asthenia of essence and blood, menstruation regulating cold dispelling, invigorating qi and benefiting blood, The effect of anti-aging, it may also be used for beautifying face and moistering lotion;Pilose antler have rouse oneself and improve body function, after asthenia universalis, prolonged illness Patient, there is preferable Tonic Action;The sweet slightly warm in nature of prepared rhizome of rehmannia, matter profit, enriching yin of both enriching blood, and energy enriching essence and nourishing marrow, it is adaptable to change The kind deficiency of liver-yin and kidney-yin, soreness and weakness of waist and knees, osteopyrexia and fever, night sweat seminal emission, Heat Diabetes, blood deficiency chlorosis, palpitation and severe palpitation, irregular menstruation, collapse Leak down blood;Motherwort cold nature, can be used to treat women's amenorrhoea, dysmenorrhoea, excessive postpartum haemorrhage, irregular menstruation, postpartum uterus receipts Contracting not complete, fetal irritability, the prolapse of uterus;Red ginseng have tonifying Qi, enriching yin, beneficial blood, promote the production of body fluid, cardiac stimulant, stomach invigorating, it is calm the effects such as;It is red Ginseng bitter slightly warm in nature, with stasis-dispelling and pain-killing, invigorate blood circulation, the effect of relieving restlessness that clears away heart-fire, it may also be used for irregular menstruation, closed dysmenorrhea, Lumps in the chest and abdomen, chest and abdomen shouting pain, hot numbness pain, sore swell and ache curative, dysphoria and insomnia;Radix Angelicae Sinensis is one of the most frequently used Chinese medicine, with enriching blood And blood, menstruction regulating and pain relieving, the effect of moisturize laxation;Spina date seed is mild-natured, tonifying liver, calming heart, and arrest sweating promotes the production of body fluid, it is adaptable to treat dysphoria not Sleep, horrified to much dream, body void hidrosis, injury thirst;Aplotaxis auriculata is warm in nature, it is adaptable to which promoting qi circulation and relieving pain, that qi-regulating is soothing the liver, stomach invigorating disappears is stagnant, together When with good spasmolysis and antihypertensive effect and antibacterial action;Eclipta is cool in nature, with hemostasis, improves immune, and liver protection resists certainly By base and the effect of chromosome damage, also with certain anti-microbial property;Corydalis tuber is warm in nature, there is promoting blood circulation, and sharp gas, analgesic is led to small Just effect;Radish seed is mild-natured, it is adaptable to which, for retention of food and drink, abdominal distention, constipation, stagnant rush down dysentery, phlegm heap soil or fertilizer over and around the roots is breathed with cough;It is small Fennel is warm in nature, there is eliminating cold to stop pain, effect of regulating qi-flowing for harmonizing stomach.Salt fennel seeds have functions that warm kidney eliminating cold to stop pain;Stir-baked CORTEX MAGNOLIAE OFFICINALIS with rhizoma zingiberis recens juice is warm in nature, tool There is qi-regulating in width, dampness elimination opens strongly fragrant, and disperse accumulations is relievingd asthma;Poria cocos is mild-natured, it is adaptable to improve oedema oliguria, phlegm retention anti-dazzle nervous, spleen eating less, just Loose stool is rushed down, confused and worried, insomnia of palpitating with fear;The bighead atractylodes rhizome is warm in nature, and with strengthening the spleen and replenishing qi, eliminate dampness and have diuretic effect, hidroschesis, antiabortive effect may be used also Improve spleen eating less, abdominal distention diarrhea, oedema, spontaneous perspiration, fetal irritability;The root of herbaceous peony has a smooth liver and relieve pain, nourishing blood for regulating menstruation, astringing YIN to stop sweating Effect, can be used for treat dizziness of having a headache, hypochondriac pain, stomachache, four limbs contraction bitterly, blood deficiency chlorosis, irregular menstruation, spontaneous perspiration, night sweat;Rhizoma cyperi property It is flat, with soothing liver-qi stagnation, regulating the flow of QI to ease the stomach, effect of menstruction regulating and pain relieving, it is adaptable to treat stagnation of QI due to depression of the liver, distending pain in the chest and hypochondrium, hernia pain, Swollen breasts, the taste stagnation of the circulation of vital energy, gastral cavity abdomen ruffian is vexed, turgor pain, irregular menstruation, closed dysmenorrhea;Sophora bud cold nature, it is bright with clearing liver Mesh, effect of cooling blood and hemostasis, it is adaptable to treat the headache of liver heat, red eye, swell pain;Radix Glycyrrhizae is mild-natured, with invigorating middle warmer and replenishing QI;Relieving spasm to stop pain; Moisten the lung and relieve the cough;Effect of purging intense heat and detonicating;Chinese cassia tree extremely hot in nature, there is mends fire supporing yang, guiding fire to origin, eliminating cold to stop pain, the work(of warming meridian Effect;Salvia japonica is mild-natured, and with clearing heat and promoting diuresis, promoting blood circulation for regulating menstruation, effect of removing toxicity for detumescence can be used to improve irregular menstruation, dysmenorrhoea;Ah Glue has enriching yin of enriching blood, and moisturizes, haemostatic effect, can be used for blood deficiency chlorosis, dizziness palpitaition, dysphoria and insomnia, xeropulmonary cough;Milk thistle It is the dry mature fruit of feverfew milk thistle, its is bitter in taste cool, there is clearing heat and detoxicating, the effect of soothing liver-gallbladder;Sesame has Filling liver kidney, benefiting essence-blood, ease constipation is dry, leads to effect of breast, helps to improve that anaemia is sallow, body fluid deficiency, dry feces, breast are few etc. Disease;The root of kudzu vine is cool in nature, has expelling pathogenic factors from muscles and skin to bring down a fever, and promoting eruption promotes the production of body fluid to quench thirst, the work(of Shengyang Zhixie, contributes to improvement table to demonstrate,prove heating, rigid neck and back Bitterly, measles without adequate eruption, pyreticosis is thirsty, and the deficiency of Yin is quenched one's thirst, and heat is purged heat dysentery, the disease such as splenasthenic diarrhea, can prevent because the deer tire property of medicine is too strong Caused excessive internal heat symptom;Dried orange peel regulating qi-flowing for strengthening spleen, the eliminating dampness and eliminating phlegm the membrane of a chicken's gizzard, stir-baked CORTEX MAGNOLIAE OFFICINALIS with rhizoma zingiberis recens juice are same to be used, burnt cold-dampness taste gas in can treating Stagnant person, enables semifluid extract of deer foetus preferably to absorb;Rabdosia lophanthide has certain maintenance effect to liver;The deer being made up of auxiliary material auxiliary agent Tire cream makes its property of medicine gentle by Radix Glycyrrhizae, eclipta and spina date seed coordinating the drug actions of a prescription, more people is taken semifluid extract of deer foetus, no Easily there is empty situation about not mended, Chinese cassia tree is respectively provided with antisepsis, can extend the storage time of semifluid extract of deer foetus with Salvia japonica, coordinates The effect of Aplotaxis auriculata and eclipta antibacterial and Green Tea Extract, the time that can decompose the extension active ingredient in semifluid extract of deer foetus, Semifluid extract of deer foetus is set to store the long period;Prepared rhizome of rehmannia, the root of herbaceous peony, the sophora bud, milk thistle, sesame, the root of kudzu vine, rabdosia lophanthide are certain with playing Liver protection effect;Meanwhile, dried orange peel, the membrane of a chicken's gizzard, spina date seed, Radix Angelicae Sinensis, Aplotaxis auriculata, fennel seeds, the bighead atractylodes rhizome have the effect of nourishing the stomach, pass through Liver-protecting and stomach-nourishing, allows body preferably to absorb the active ingredient such as deer tire powder, pilose antler, motherwort in semifluid extract of deer foetus, preferably reaches Benefiting qi and nourishing blood, liver-protecting and stomach-nourishing, menstruation regulating cold dispelling, tonifying kidney and benefiting sperm, effect of enriching yin beauty treatment.
Preferably, the mass fraction of each component of the auxiliary material auxiliary agent and each component is:100~200 parts of honey, ice 100~200 parts of sugar, 100~200 parts of yellow rice wine, 700~1400 parts of brown sugar.
By using above-mentioned technical proposal, honey is a kind of nutritious natural nourishing food, for heart disease, blood high Pressure, tuberculosis, illness in eye, hepatopathy, dysentery, constipation, anaemia, the nervous system disease, gastric duodenal ulcer disease etc. have well Medical assistance effect;Rock sugar is sweet, mild-natured, enters lung, the spleen channel;Have a tonifying middle-Jiao and Qi, and stomach moistening lung effect;Rock sugar yin-nourishing is given birth to Tianjin, moistens the lung and relieve the cough, effect of heat-clearing and fire-reducing;Yellow rice wine, containing sugar, dextrin, organic acid, protein, amino acid, glycerine, senior The active ingredients such as alcohol, vitamin, inorganic salts, with promoting blood circulation, promoting blood circulation, blood-nourishing, moreover it is possible to promote the property of medicine of donkey-hide gelatin to volatilize;Brown sugar energy Make body warmer, increase energy, active qi and blood accelerates blood circulation;The herbal paste for enduring out by these auxiliary agents is less prone to Jiao Stink, lotion is fine and smooth, soft and smooth, and surface has one layer of gloss.
Preferably, the honey is from sophorae honey, Mel Jujubae, Radix Codonopsis honey, matrimony vine honey, motherwort honey, the one of honey of lungan flowers Plant or various mixtures.
By using above-mentioned technical proposal, sophorae honey is cool in nature, can be used to nurse liver, and it is dry to improve vexed heat, heart is vexed has palpitation, Slight Hypertension, have blood in stool, hemorrhoid blood, hemoptysis person, neurasthenia, nervous giddy, insomnia, deficiency of vital energy and physically weak, apocleisis, malaise etc.;Jujube Nectar, Radix Codonopsis honey, matrimony vine honey, motherwort honey each contribute to strengthening spleen and nourishing stomach, blood-enriching tranquillizing.Beneficial to Light-headedness, failure of memory, Liver nourishing, malaise, lean and haggard, menorrhagia;Honey of lungan flowers has the beneficial spleen of nourishing blood and tranquilization, appetizing, beauty treatment clearing heat and moistening dryness, mends Middle the effect of, the palpitation and restlessness caused to the heart spleen deficiency of blood, insomnia and memory subtract also certain auxiliary curative effect, particularly suitable women It is edible;The honey of mentioned kind has enriching yin effect, contributes to nourishing qi and blood, lifts the property of medicine.
Preferably, content of beary metal is less than 15ppm in the donkey-hide gelatin.
By using above-mentioned technical proposal, injury of the heavy metal to human body is very big, knows from experience to cerebral nervous system into people Cause to damage, cause the adverse reaction such as force decline, headache, emotional, nauseous, donkey-hide gelatin of the content of beary metal less than 15ppm is remote Less than national standard, the donkey-hide gelatin is smaller to the side effect of human body during taking.
Second object of the present invention is to provide a kind of preparation technology of semifluid extract of deer foetus, the semifluid extract of deer foetus nutrition boiled by the method Loss is smaller, and the active ingredient in each component can be fully extracted.
Above-mentioned technical purpose of the invention technical scheme is that:
A kind of preparation technology of semifluid extract of deer foetus, comprises the following steps:
(1) by prepared rhizome of rehmannia, motherwort, red ginseng, the red sage root, Radix Angelicae Sinensis, spina date seed, Aplotaxis auriculata, eclipta, corydalis tuber, radish seed, fennel fruit Perfume, stir-baked CORTEX MAGNOLIAE OFFICINALIS with rhizoma zingiberis recens juice, Poria cocos, the bighead atractylodes rhizome, the root of herbaceous peony, the sophora bud, Radix Glycyrrhizae, Chinese cassia tree, Salvia japonica, milk thistle, sesame, the root of kudzu vine, dried orange peel, the membrane of a chicken's gizzard, Rabdosia lophanthide is polished into powder by medicinal herb grinder respectively;
(2) red ginseng, the red sage root, Radix Angelicae Sinensis, Aplotaxis auriculata, stir-baked CORTEX MAGNOLIAE OFFICINALIS with rhizoma zingiberis recens juice, Poria cocos, Chinese cassia tree are added water 100~120 DEG C and decocts 1~2h;
(3) to step (2) add prepared rhizome of rehmannia, motherwort, spina date seed, fennel seeds, corydalis tuber, radish seed, the bighead atractylodes rhizome, the root of herbaceous peony, rhizoma cyperi, The sophora bud, Radix Glycyrrhizae, Salvia japonica, milk thistle, sesame, the root of kudzu vine, dried orange peel, the membrane of a chicken's gizzard, rabdosia lophanthide, 100~120 DEG C are continued to decoct 1~2h, Filtrate is taken after filtering;
(4) after by deer tire, the cleaning of pilose antler unhairing, dry, powder is polished into respectively, be stirring evenly and then adding into the filtrate of step (3) In 100~120 DEG C continue decoct 0.5~1h;
(5) lower the temperature 70~80 DEG C, to honey, rock sugar, yellow rice wine, brown sugar, donkey-hide gelatin is added in step (4), boil preparation for black The paste of stiff;
(6) after natural cooling, semifluid extract of deer foetus is obtained final product.
By using above-mentioned technical proposal, by the medicinal material in component according to dissolving complexity, carry out by several times effectively into Divide and extract, the medicinal material of active ingredient indissoluble is less prone to and causes extracted amount less because extraction time is very few, and high temperature is perishable Active ingredient be not easy to occur due to extraction time it is long caused by the property of medicine go bad, honey, donkey-hide gelatin etc. be rich in amino acid pair Temperature sensitive active ingredient is added after cooling, will not cause its active ingredient that enzymolysis failure occurs because temperature is too high, The semifluid extract of deer foetus lotion concentrated after result filtering is fine and smooth, taste good.
Preferably, step (1) Chinese medicine is by after medicinal herb grinder polishing, grain graininess is 20~30 μm.
Extracted after being smashed by using above-mentioned technical proposal, medicinal material, extraction can be made more abundant, undersized meeting Cause that in filtration step filter residue cannot be adequately filtered out, and granularity is excessive, be unfavorable for extracting abundant, by Task-size Controlling 20~ 30 μm, while the extraction that active ingredient in medicinal material is obtained can be made abundant, filter residue residual is less prone in filter process Situation.
Preferably, the fennel seeds in the step (2) are by green salt frying.
By using above-mentioned technical proposal, green salt is cold in nature, has functions that improving eyesight cool blood, can be used for fall fire, fennel seeds warp Green salt frying is crossed, effect of eliminating cold to stop pain can be strengthened.
Preferably, after the rhizoma cyperi and corydalis tuber in the step (2) submerge 24h with vinegar respectively, being placed in frying in pot and doing It is dry.
By using above-mentioned technical proposal, rhizoma cyperi is strengthened through qi-regulating effect after vinegar system, in treatment irregular menstruation, chest and abdomen swelling and pain The effect promoting of aspect, meanwhile, also there is protecting and nourishing liver;After corydalis tuber vinegar system, the effect of analgesic is enhanced.
Preferably, deer blood tire of the deer tire for sika deer.
By using above-mentioned technical proposal, protein, polypeptide, amino acid, nucleic acid, vitamin etc. in the deer blood tire of sika deer Content is tens times of common deer tire, and compared to common deer tire, effect of the deer blood tire in terms of health care is more preferable.
Preferably, the process that boils is boiled using marmite.
By using above-mentioned technical proposal, such as rhizoma cyperi medicinal material cannot be boiled with metal pan, it is important in it is contained because The composition such as contained tannin, organic acid in Chinese medicine, can chemically react with iron, copper, aluminium, tin, produce deposit, right after drinking Body has infringement.
In sum, the invention has the advantages that:
1. the Chinese cassia tree in the semifluid extract of deer foetus is respectively provided with antisepsis with Salvia japonica, can extend the storage time of semifluid extract of deer foetus, coordinates cloud The effect of the banksia rose and eclipta antibacterial and Green Tea Extract, the time that can decompose the extension active ingredient in semifluid extract of deer foetus, makes Semifluid extract of deer foetus can store the long period;
2. by deer tire and the proportioning of other Chinese medicines, the semifluid extract of deer foetus has and preferably has benefiting qi and nourishing blood, menstruation regulating cold dispelling, kidney tonifying benefit The effects such as essence, enriching yin beauty treatment.
Specific embodiment
Donkey-hide gelatin is bought from Shandong Gu Ayuan Food Co., Ltd, and wherein content of beary metal is less than 15ppm.
Deer tire is selected from the deer blood tire cultivated by the present inventor in Ningbo of Zhejiang Cixi with the doe in hair Sika Deer Farming base.
Green salt and fennel seeds are pressed into mass parts green salt:Fennel seeds=5:4 add in ceramic pan, and small fire stir-fries, to surface temperature Degree is up to 80 DEG C.
Rhizoma cyperi is immersed in vinegar, is taken out after dipping 24h, be placed in small fire in ceramic pan and stir-fry to drying.
Corydalis tuber is immersed in vinegar, is taken out after dipping 24h, be placed in small fire in ceramic pan and stir-fry to drying.
Deer tire is cleaned, stripping and slicing is immersed in vinegar, taken out after dipping 10h, be placed in and drying is baked in baking box, ground and be in Powdery.
Pilose antler is cleaned, unhairing, cut into slices, be immersed in vinegar, taken out after dipping 10h, be placed in and drying is baked in baking box, ground System is in powdery.
Honey is from sophorae honey, Mel Jujubae, Radix Codonopsis is sweet, matrimony vine is sweet, one or more mixing of motherwort honey, honey of lungan flowers Thing.
Embodiment one
(1) by prepared rhizome of rehmannia, motherwort, red ginseng, the red sage root, Radix Angelicae Sinensis, spina date seed, Aplotaxis auriculata, eclipta, corydalis tuber, radish seed, fennel fruit Perfume, stir-baked CORTEX MAGNOLIAE OFFICINALIS with rhizoma zingiberis recens juice, Poria cocos, the bighead atractylodes rhizome, the root of herbaceous peony, the sophora bud, Radix Glycyrrhizae, Chinese cassia tree, Salvia japonica, milk thistle, sesame, the root of kudzu vine, dried orange peel, the membrane of a chicken's gizzard, Rabdosia lophanthide, is polishing to powder granule granularity for 25 μm by medicinal herb grinder respectively;
(2) by following components by 5 parts of mass parts red ginseng, 5 parts of the red sage root, 6 parts of Radix Angelicae Sinensis, 6 parts of Aplotaxis auriculata, 7 parts of stir-baked CORTEX MAGNOLIAE OFFICINALIS with rhizoma zingiberis recens juice, 7 parts of Poria cocos, 8 parts of Chinese cassia tree is poured into marmite, and add water 100 parts of 100 DEG C of decoction 2h;
(3) in following components being added into step (2) by mass parts, 5 parts of prepared rhizome of rehmannia, 5 parts of motherwort, 6 parts of spina date seed, fennel seeds 6 Part, 7 parts of corydalis tuber, 7 parts of radish seed, 6 parts of the bighead atractylodes rhizome, 6 parts of the root of herbaceous peony, 7 parts of rhizoma cyperi, 8 parts of the sophora bud, 10 parts of Radix Glycyrrhizae, 6 parts of Salvia japonica, water Fly 7 parts of Ji, 8 parts of sesame, 6 parts of the root of kudzu vine, 10 parts of dried orange peel, 5 parts of the membrane of a chicken's gizzard, 5 parts of rabdosia lophanthide, 100 DEG C are continued to decoct 2h, are taken after filtering Filtrate;
(4) following components are stirring evenly and then adding into 100 in the filtrate of step (3) by 100 parts of mass parts deer tire, 5 parts of pilose antler DEG C continue decoct 1h;
(5) lower the temperature 70 DEG C, to 50 parts of sophorae honey of addition, 50 parts of Radix Codonopsis honey, 100 parts of rock sugar, 100 parts of yellow rice wine, brown sugar in step (4) 1400 parts, 80 parts of donkey-hide gelatin, boil the paste that preparation is black stiff;
(6) after natural cooling, semifluid extract of deer foetus is obtained final product.
Embodiment two
(1) by prepared rhizome of rehmannia, motherwort, red ginseng, the red sage root, Radix Angelicae Sinensis, spina date seed, Aplotaxis auriculata, eclipta, corydalis tuber, radish seed, fennel fruit Perfume, stir-baked CORTEX MAGNOLIAE OFFICINALIS with rhizoma zingiberis recens juice, Poria cocos, the bighead atractylodes rhizome, the root of herbaceous peony, the sophora bud, Radix Glycyrrhizae, Chinese cassia tree, Salvia japonica, milk thistle, sesame, the root of kudzu vine, dried orange peel, the membrane of a chicken's gizzard, Rabdosia lophanthide, is polishing to powder granule granularity for 25 μm by medicinal herb grinder respectively;
(2) following components are pressed into 8 parts of mass parts red ginseng, 8 parts of the red sage root, 7 parts of Radix Angelicae Sinensis, 10 parts of Aplotaxis auriculata, 5 parts of stir-baked CORTEX MAGNOLIAE OFFICINALIS with rhizoma zingiberis recens juice, Poria cocos 5 Part, 10 parts of Chinese cassia tree are poured into marmite, and add water 100 parts of 110 DEG C of decoction 2h;
(3) in following components being added into step (2) by mass parts, 10 parts of prepared rhizome of rehmannia, 10 parts of motherwort, 5 parts of spina date seed, fennel seeds 10 parts, 10 parts of corydalis tuber, 5 parts of radish seed, 10 parts of the bighead atractylodes rhizome, 5 parts of the root of herbaceous peony, 5 parts of rhizoma cyperi, 10 parts of the sophora bud, 5 parts of Radix Glycyrrhizae, Salvia japonica 10 Part, 10 parts of milk thistle, 10 parts of sesame, 5 parts of the root of kudzu vine, 8 parts of dried orange peel, 7 parts of the membrane of a chicken's gizzard, 8 parts of rabdosia lophanthide, 110 DEG C are continued to decoct 2h, mistake Filtrate is taken after filter;
(4) following components are stirring evenly and then adding into 110 in the filtrate of step (3) by 200 parts of mass parts deer tire, 10 parts of pilose antler DEG C continue decoct 1h;
(5) lower the temperature 80 DEG C, to adding 100 parts of sophorae honey, 100 parts of honey of lungan flowers, 100 parts of rock sugar, 200 parts of yellow rice wine, red in step (4) Sugared 1000 parts, 100 parts of donkey-hide gelatin, boil the paste that preparation is black stiff;
(6) after natural cooling, semifluid extract of deer foetus is obtained final product.
Embodiment three
(1) by prepared rhizome of rehmannia, motherwort, red ginseng, the red sage root, Radix Angelicae Sinensis, spina date seed, Aplotaxis auriculata, eclipta, corydalis tuber, radish seed, fennel fruit Perfume, stir-baked CORTEX MAGNOLIAE OFFICINALIS with rhizoma zingiberis recens juice, Poria cocos, the bighead atractylodes rhizome, the root of herbaceous peony, the sophora bud, Radix Glycyrrhizae, Chinese cassia tree, Salvia japonica, milk thistle, sesame, the root of kudzu vine, dried orange peel, the membrane of a chicken's gizzard, Rabdosia lophanthide, is polishing to powder granule granularity for 20 μm by medicinal herb grinder respectively;
(2) following components are pressed into 10 parts of mass parts red ginseng, 10 parts of the red sage root, 10 parts of Radix Angelicae Sinensis, 10 parts of Aplotaxis auriculata, 10 parts of stir-baked CORTEX MAGNOLIAE OFFICINALIS with rhizoma zingiberis recens juice, Fu 10 parts of Siberian cocklebur, 10 parts of Chinese cassia tree are poured into marmite, and add water 100 parts of 120 DEG C of decoction 2h;
(3) in following components being added into step (2) by mass parts, 10 parts of prepared rhizome of rehmannia, 10 parts of motherwort, 10 parts of spina date seed, fennel fruit Fragrant 10 parts, 10 parts of corydalis tuber, 10 parts of radish seed, 10 parts of the bighead atractylodes rhizome, 10 parts of the root of herbaceous peony, 10 parts of rhizoma cyperi, 10 parts of the sophora bud, 10 parts of Radix Glycyrrhizae, mouse Tail grass 10 parts, 10 parts of milk thistle, 10 parts of sesame, 10 parts of the root of kudzu vine, 10 parts of dried orange peel, 10 parts of the membrane of a chicken's gizzard, 10 parts of rabdosia lophanthide, 120 DEG C after It is continuous to decoct 2h, filtrate is taken after filtering;
(4) following components are stirring evenly and then adding into 120 in the filtrate of step (3) by 200 parts of mass parts deer tire, 10 parts of pilose antler DEG C continue decoct 1h;
(5) lower the temperature 80 DEG C, to add in step (4) 50 parts of Mel Jujubae, 50 parts of motherwort honey, 50 parts of honey of lungan flowers, 150 parts of rock sugar, 200 parts of yellow rice wine, 1200 parts of brown sugar, 80 parts of donkey-hide gelatin, boil the paste that preparation is black stiff;
(6) after natural cooling, semifluid extract of deer foetus is obtained final product.
Example IV
(1) by prepared rhizome of rehmannia, motherwort, red ginseng, the red sage root, Radix Angelicae Sinensis, spina date seed, Aplotaxis auriculata, eclipta, corydalis tuber, radish seed, fennel fruit Perfume, stir-baked CORTEX MAGNOLIAE OFFICINALIS with rhizoma zingiberis recens juice, Poria cocos, the bighead atractylodes rhizome, the root of herbaceous peony, the sophora bud, Radix Glycyrrhizae, Chinese cassia tree, Salvia japonica, milk thistle, sesame, the root of kudzu vine, dried orange peel, the membrane of a chicken's gizzard, Rabdosia lophanthide, is polishing to powder granule granularity for 25 μm by medicinal herb grinder respectively;
(2) by following components by 8 parts of mass parts red ginseng, 7 parts of the red sage root, 9 parts of Radix Angelicae Sinensis, 7 parts of Aplotaxis auriculata, 8 parts of stir-baked CORTEX MAGNOLIAE OFFICINALIS with rhizoma zingiberis recens juice, 6 parts of Poria cocos, 6 parts of Chinese cassia tree is poured into marmite, and add water 100 parts of 120 DEG C of decoction 2h;
(3) in following components being added into step (2) by mass parts, 10 parts of prepared rhizome of rehmannia, 5 parts of motherwort, 5 parts of spina date seed, fennel seeds 5 Part, 10 parts of corydalis tuber, 10 parts of radish seed, 5 parts of the bighead atractylodes rhizome, 5 parts of the root of herbaceous peony, 10 parts of rhizoma cyperi, 10 parts of the sophora bud, 10 parts of Radix Glycyrrhizae, Salvia japonica 5 Part, 8 parts of milk thistle, 5 parts of sesame, 10 parts of the root of kudzu vine, 5 parts of dried orange peel, 8 parts of the membrane of a chicken's gizzard, 7 parts of rabdosia lophanthide, 110 DEG C are continued to decoct 1.5h, Filtrate is taken after filtering;
(4) following components are stirring evenly and then adding into 100 in the filtrate of step (3) by 150 parts of mass parts deer tire, 8 parts of pilose antler DEG C continue decoct 1h;
(5) lower the temperature 75 DEG C, to add in step (4) 50 parts of Mel Jujubae, 50 parts of Radix Codonopsis honey, 50 parts of matrimony vine honey, 50 parts of motherwort honey, 150 parts of rock sugar, 150 parts of yellow rice wine, 800 parts of brown sugar, 80 parts of donkey-hide gelatin, boil the paste that preparation is black stiff;
(6) after natural cooling, semifluid extract of deer foetus is obtained final product.
Embodiment five
(1) by prepared rhizome of rehmannia, motherwort, red ginseng, the red sage root, Radix Angelicae Sinensis, spina date seed, Aplotaxis auriculata, eclipta, corydalis tuber, radish seed, fennel fruit Perfume, stir-baked CORTEX MAGNOLIAE OFFICINALIS with rhizoma zingiberis recens juice, Poria cocos, the bighead atractylodes rhizome, the root of herbaceous peony, the sophora bud, Radix Glycyrrhizae, Chinese cassia tree, Salvia japonica, milk thistle, sesame, the root of kudzu vine, dried orange peel, the membrane of a chicken's gizzard, Rabdosia lophanthide, is polishing to powder granule granularity for 25 μm by medicinal herb grinder respectively;
(2) following components are pressed into 8 parts of mass parts red ginseng, 7 parts of the red sage root, 5 parts of Radix Angelicae Sinensis, 5 parts of Aplotaxis auriculata, 10 parts of stir-baked CORTEX MAGNOLIAE OFFICINALIS with rhizoma zingiberis recens juice, Poria cocos 10 Part, 10 parts of Chinese cassia tree are poured into marmite, and add water 100 parts of 100 DEG C of decoction 2h;
(3) in following components being added into step (2) by mass parts, 10 parts of prepared rhizome of rehmannia, 10 parts of motherwort, 8 parts of spina date seed, fennel seeds 8 parts, 6 parts of corydalis tuber, 6 parts of radish seed, 5 parts of the bighead atractylodes rhizome, 5 parts of the root of herbaceous peony, 7 parts of rhizoma cyperi, 7 parts of the sophora bud, 5 parts of Radix Glycyrrhizae, 10 parts of Salvia japonica, water Fly the powder of Ji 10,10 parts of sesame, 10 parts of the root of kudzu vine, 10 parts of dried orange peel, 8 parts of the membrane of a chicken's gizzard, 10 parts of rabdosia lophanthide, 110 DEG C are continued to decoct 2h, filtering After take filtrate;
(4) following components are stirring evenly and then adding into 120 in the filtrate of step (3) by 180 parts of mass parts deer tire, 8 parts of pilose antler DEG C continue decoct 1h;
(5) lower the temperature 63 DEG C, to add in step (4) 60 parts of sophorae honey, 60 parts of motherwort honey, 80 parts of honey of lungan flowers, 180 parts of rock sugar, 160 parts of yellow rice wine, 700 parts of brown sugar, 120 parts of donkey-hide gelatin, boil the paste that preparation is black stiff;
(6) after natural cooling, semifluid extract of deer foetus is obtained final product.
Embodiment six
(1) by prepared rhizome of rehmannia, motherwort, red ginseng, the red sage root, Radix Angelicae Sinensis, spina date seed, Aplotaxis auriculata, eclipta, corydalis tuber, radish seed, fennel fruit Perfume, stir-baked CORTEX MAGNOLIAE OFFICINALIS with rhizoma zingiberis recens juice, Poria cocos, the bighead atractylodes rhizome, the root of herbaceous peony, the sophora bud, Radix Glycyrrhizae, Chinese cassia tree, Salvia japonica, milk thistle, sesame, the root of kudzu vine, dried orange peel, the membrane of a chicken's gizzard, Rabdosia lophanthide, is polishing to powder granule granularity for 30 μm by medicinal herb grinder respectively;
(2) following components are pressed into 8 parts of mass parts red ginseng, 8 parts of the red sage root, 5 parts of Radix Angelicae Sinensis, 5 parts of Aplotaxis auriculata, 10 parts of stir-baked CORTEX MAGNOLIAE OFFICINALIS with rhizoma zingiberis recens juice, Poria cocos 10 Part, 6 parts of Chinese cassia tree are poured into marmite, and add water 100 parts of 120 DEG C of decoction 2h;
(3) in following components being added into step (2) by mass parts, 7 parts of prepared rhizome of rehmannia, 6 parts of motherwort, 10 parts of spina date seed, fennel seeds 8 Part, 8 parts of corydalis tuber, 5 parts of radish seed, 8 parts of the bighead atractylodes rhizome, 8 parts of the root of herbaceous peony, 6 parts of rhizoma cyperi, 6 parts of the sophora bud, 10 parts of Radix Glycyrrhizae, 10 parts of Salvia japonica, water Fly 8 parts of Ji, 8 parts of sesame, 9 parts of the root of kudzu vine, 9 parts of dried orange peel, 10 parts of the membrane of a chicken's gizzard, 10 parts of rabdosia lophanthide, 110 DEG C are continued to decoct 1.5h, filtering After take filtrate;
(4) following components are stirring evenly and then adding into 100 in the filtrate of step (3) by 170 parts of mass parts deer tire, 6 parts of pilose antler DEG C continue decoct 1h;
(5) lower the temperature 70 DEG C, to add in step (4) 100 parts of matrimony vine honey, 120 parts of rock sugar, 150 parts of yellow rice wine, 1000 parts of brown sugar, Ah 110 parts of glue, boils the paste that preparation is black stiff;
(6) after natural cooling, semifluid extract of deer foetus is obtained final product.
Comparative example one
The filtrate obtained by step (1), (2), (3) in embodiment one is replaced with the deionized water of phase homogenous quantities, is directly entered Row step (4), (5) are brewed into paste.
Comparative example two
The filtrate obtained by step (1), (2), (3) in embodiment two is replaced with the deionized water of phase homogenous quantities, is directly entered Row step (4), (5) are brewed into paste.
Comparative example three
The filtrate obtained by step (1), (2), (3) in embodiment three is replaced with the deionized water of phase homogenous quantities, is directly entered Row step (4), (5) are brewed into paste.
Comparative example four
The filtrate obtained by step (1), (2), (3) in example IV is replaced with the deionized water of phase homogenous quantities, is directly entered Row step (4), (5) are brewed into paste.
Comparative example five
The filtrate obtained by step (1), (2), (3) in embodiment five is replaced with the deionized water of phase homogenous quantities, is directly entered Row step (4), (5) are brewed into paste.
Comparative example six
The filtrate obtained by step (1), (2), (3) in embodiment six is replaced with the deionized water of phase homogenous quantities, is directly entered Row step (4), (5) are brewed into paste.
By above-described embodiment and 12 groups of semifluid extract of deer foetus are prepared into, after 6 groups of semifluid extract of deer foetus are coated into wafers, are placed in 23 DEG C, Placed under 30%RH, the time of following phenomenon occurs in record semifluid extract of deer foetus:
(1) the complete oil suction of wafer;
(2) there is peculiar smell;
(3) there is thread white hair in semifluid extract of deer foetus surface.
The record time see the table below:
To sum up, selection embodiment five, by the formula, greatly improves the holding time of semifluid extract of deer foetus as optimum embodiment.
A collection of semifluid extract of deer foetus was made at interval of 7 days by the Recipe of embodiment five, 3 batches altogether, A1, A2, A3 is marked respectively, The semifluid extract of deer foetus for completing is placed in 4 DEG C of refrigerators and preserves.
100 mouse are divided into 4 batches, 25 every batch, are built using the low iron feed combination method that periodically classes are over is given Vertical anemia mice model, labeled as B1, B2, B3, B4.
Mouse is proceeded by within 1 day to after being made in A3 to feed, A1 groups semifluid extract of deer foetus is fed into B1 group mouse, by A2 group semifluid extract of deer foetus B2 group mouse are fed, A3 groups semifluid extract of deer foetus is fed into B3 group mouse, daily feeding 0.5g, while continuing the low iron feed of feeding.
After feeding 7 days, randomly select after wherein 12 mouse pluck eyeball for every group and take blood, after room temperature places 1h, 2500r/min Centrifugation 15min separates serum, carries out ELISA tests, tests SCF, averages.
After feeding 14 days, randomly selected from remaining 13 mouse after 12 mouse pluck eyeball for every group and take blood, room temperature is placed After 1h, 2500r/min centrifugations 15min separates serum, is tested by ELISA, tests SCF, record of averaging.
Test result see the table below:
B1 B2 B3 B4
SCF(ng/L) 57.193 57.332 57.420 23.498
By upper table, the semifluid extract of deer foetus can have the SCF activity that is significantly improved so as to inducing hematopoietic stem cell Proliferation, Differentiation Effect, reach the effect of Bushen Shengxue, and the SCF difference values of tri- groups of mouse of B1, B2, B3 are smaller, illustrate the storage of the semifluid extract of deer foetus Deposit effect preferably, active ingredient is not easily decomposed during storage.
This specific embodiment is only explanation of the invention, and it is not limitation of the present invention, people in the art Member can make the modification without creative contribution to the present embodiment as needed after this specification is read, but as long as at this All protected by Patent Law in the right of invention.

Claims (10)

1. a kind of semifluid extract of deer foetus, it is characterised in that the semifluid extract of deer foetus following components is constituted, the mass fraction of each component and each component For:100 ~ 200 parts of deer tire powder, 5 ~ 10 parts of pilose antler, 5 ~ 10 parts of prepared rhizome of rehmannia, 5 ~ 10 parts of motherwort, 5 ~ 10 parts of red ginseng, the red sage root 5 ~ 10 Part, 5 ~ 10 parts of Radix Angelicae Sinensis, 5 ~ 10 parts of spina date seed, 5 ~ 10 parts of Aplotaxis auriculata, 5 ~ 10 parts of eclipta, 5 ~ 10 parts of corydalis tuber, radish seed 5 ~ 10 Part, 5 ~ 10 parts of fennel seeds, 5 ~ 10 parts of stir-baked CORTEX MAGNOLIAE OFFICINALIS with rhizoma zingiberis recens juice, 5 ~ 10 parts of Poria cocos, 5 ~ 10 parts of the bighead atractylodes rhizome, 5 ~ 10 parts of the root of herbaceous peony, 5 ~ 10 parts of rhizoma cyperi, the sophora bud 5 ~ 10 parts, 5 ~ 10 parts of Radix Glycyrrhizae, 5 ~ 10 parts of Chinese cassia tree, 5 ~ 10 parts of Salvia japonica, 5 ~ 10 parts of milk thistle, 5 ~ 10 parts of sesame, 5 ~ 10 parts of the root of kudzu vine, 5 ~ 10 parts of dried orange peel, 5 ~ 10 parts of the membrane of a chicken's gizzard, 5 ~ 10 parts of rabdosia lophanthide, 80 ~ 120 parts of donkey-hide gelatin, 1000 ~ 2000 parts of auxiliary material auxiliary agent.
2. a kind of semifluid extract of deer foetus according to claim 1, it is characterised in that each component and each component of the auxiliary material auxiliary agent Mass fraction be:100 ~ 200 parts of honey, 100 ~ 200 parts of rock sugar, 100 ~ 200 parts of yellow rice wine, 700 ~ 1400 parts of brown sugar.
3. a kind of semifluid extract of deer foetus according to claim 2, it is characterised in that the honey selects sophorae honey, Mel Jujubae, Radix Codonopsis Honey, matrimony vine honey, motherwort honey, one kind of honey of lungan flowers.
4. a kind of semifluid extract of deer foetus according to claim 1, it is characterised in that content of beary metal is less than 15ppm in the donkey-hide gelatin.
5. the preparation technology of a kind of semifluid extract of deer foetus according to claim any one of 1-4, it is characterised in that including following step Suddenly:
(1)By prepared rhizome of rehmannia, motherwort, red ginseng, the red sage root, Radix Angelicae Sinensis, spina date seed, Aplotaxis auriculata, eclipta, corydalis tuber, radish seed, fennel fruit Perfume, stir-baked CORTEX MAGNOLIAE OFFICINALIS with rhizoma zingiberis recens juice, Poria cocos, the bighead atractylodes rhizome, the root of herbaceous peony, the sophora bud, Radix Glycyrrhizae, Chinese cassia tree, Salvia japonica, milk thistle, sesame, the root of kudzu vine, dried orange peel, the membrane of a chicken's gizzard, Rabdosia lophanthide is polished into powder by medicinal herb grinder respectively;
(2)Red ginseng, the red sage root, Radix Angelicae Sinensis, Aplotaxis auriculata, stir-baked CORTEX MAGNOLIAE OFFICINALIS with rhizoma zingiberis recens juice, Poria cocos, Chinese cassia tree are added water 100 ~ 120 DEG C and decocts 1 ~ 2h;
(3)To step(2)Add prepared rhizome of rehmannia, motherwort, spina date seed, fennel seeds, corydalis tuber, radish seed, the bighead atractylodes rhizome, the root of herbaceous peony, rhizoma cyperi, The sophora bud, Radix Glycyrrhizae, Salvia japonica, milk thistle, sesame, the root of kudzu vine, dried orange peel, the membrane of a chicken's gizzard, rabdosia lophanthide, 100 ~ 120 DEG C are continued to decoct 1 ~ 2h, mistake Filtrate is taken after filter;
(4)After by deer tire, the cleaning of pilose antler unhairing, dry, powder is polished into respectively, be stirring evenly and then adding into step(3)Filtrate In 100 ~ 120 DEG C continue decoct 0.5 ~ 1h;
(5)70 ~ 80 DEG C of cooling, to step(4)Middle addition honey, rock sugar, yellow rice wine, brown sugar, donkey-hide gelatin, boil preparation for black is thick Thick paste;
(6)After natural cooling, semifluid extract of deer foetus is obtained final product.
6. a kind of preparation technology of semifluid extract of deer foetus according to claim 5, it is characterised in that the step(1)Chinese medicine is equal By after medicinal herb grinder polishing, grain graininess is 20 ~ 30 μm.
7. a kind of preparation technology of semifluid extract of deer foetus according to claim 5, it is characterised in that the step(2)In fennel fruit Perfume is by green salt frying.
8. a kind of preparation technology of semifluid extract of deer foetus according to claim 5, it is characterised in that the step(2)In rhizoma cyperi After submerging 24h with vinegar respectively with corydalis tuber, it is placed in frying in pot and dries.
9. the preparation technology of a kind of semifluid extract of deer foetus according to claim 5, it is characterised in that the deer tire is the deer of sika deer Blood tire.
10. the preparation technology of a kind of semifluid extract of deer foetus according to claim 5, it is characterised in that the process that boils is used Marmite is boiled.
CN201710039445.4A 2017-01-19 2017-01-19 Deer foetus semifluid extract and preparation process thereof Pending CN106692589A (en)

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CN108403854A (en) * 2018-04-28 2018-08-17 黔西南州睿杰鹿业发展有限公司 A kind of semifluid extract of deer foetus and preparation method thereof

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CN108245666A (en) * 2018-02-12 2018-07-06 北京九鼎锐创生物医药科技社旗有限公司 A kind of Chinese medicine composition of strengthen immunity
CN108403854A (en) * 2018-04-28 2018-08-17 黔西南州睿杰鹿业发展有限公司 A kind of semifluid extract of deer foetus and preparation method thereof

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