CN108245666A - A kind of Chinese medicine composition of strengthen immunity - Google Patents

A kind of Chinese medicine composition of strengthen immunity Download PDF

Info

Publication number
CN108245666A
CN108245666A CN201810145234.3A CN201810145234A CN108245666A CN 108245666 A CN108245666 A CN 108245666A CN 201810145234 A CN201810145234 A CN 201810145234A CN 108245666 A CN108245666 A CN 108245666A
Authority
CN
China
Prior art keywords
parts
medicine composition
chinese medicine
strengthen immunity
chinese
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201810145234.3A
Other languages
Chinese (zh)
Inventor
刘刚
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beijing Jiuding Vetrun Biomedical Technology Co Ltd Sheqi
Original Assignee
Beijing Jiuding Vetrun Biomedical Technology Co Ltd Sheqi
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beijing Jiuding Vetrun Biomedical Technology Co Ltd Sheqi filed Critical Beijing Jiuding Vetrun Biomedical Technology Co Ltd Sheqi
Priority to CN201810145234.3A priority Critical patent/CN108245666A/en
Publication of CN108245666A publication Critical patent/CN108245666A/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
    • A61K36/258—Panax (ginseng)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7016—Disaccharides, e.g. lactose, lactulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/36—Skin; Hair; Nails; Sebaceous glands; Cerumen; Epidermis; Epithelial cells; Keratinocytes; Langerhans cells; Ectodermal cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/58—Reptiles
    • A61K35/583—Snakes; Lizards, e.g. chameleons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/56—Materials from animals other than mammals
    • A61K35/63—Arthropods
    • A61K35/64—Insects, e.g. bees, wasps or fleas
    • A61K35/644—Beeswax; Propolis; Royal jelly; Honey
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/13—Coniferophyta (gymnosperms)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/235—Foeniculum (fennel)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/44—Ebenaceae (Ebony family), e.g. persimmon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/54—Lauraceae (Laurel family), e.g. cinnamon or sassafras
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/60—Moraceae (Mulberry family), e.g. breadfruit or fig
    • A61K36/605—Morus (mulberry)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/72—Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
    • A61K36/725—Ziziphus, e.g. jujube
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/734—Crataegus (hawthorn)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/73—Rosaceae (Rose family), e.g. strawberry, chokeberry, blackberry, pear or firethorn
    • A61K36/736—Prunus, e.g. plum, cherry, peach, apricot or almond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/75—Rutaceae (Rue family)
    • A61K36/752—Citrus, e.g. lime, orange or lemon
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/77—Sapindaceae (Soapberry family), e.g. lychee or soapberry
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/81—Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
    • A61K36/815—Lycium (desert-thorn)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/894—Dioscoreaceae (Yam family)
    • A61K36/8945—Dioscorea, e.g. yam, Chinese yam or water yam
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8962—Allium, e.g. garden onion, leek, garlic or chives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/39—Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
    • A61K2236/30—Extraction of the material
    • A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
    • A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction

Abstract

The present invention provides a kind of Chinese medicine composition of strengthen immunity, bulk pharmaceutical chemicals composition include：Ginseng, Chinese torreyanut, almond, wild jujube, mulberries, pallas pit viper, Chinese yam, arillus longan, dateplum persimmon, bitter orange flower, hawthorn, matrimony vine, Longstamen Onion Bulb, dark plum, jujube, hoveniae semoveniae semen, fennel seeds, Chinese cassia tree and donkey-hide gelatin.The present invention also provides the herbal pastes of strengthen immunity prepared by a kind of Chinese medicine composition with above-mentioned strengthen immunity.The Chinese medicine composition prescription of strengthen immunity of the present invention is rigorous, and compatibility is accurate, has effects that adjust human body gas, blood, the balance of yin, yang and enhancing matrix immunity.

Description

A kind of Chinese medicine composition of strengthen immunity
Technical field
The present invention relates to the field of Chinese medicines, and in particular to the Chinese medicine composition of strengthen immunity a kind of and utilizes the Chinese traditional medicine composition The herbal paste of strengthen immunity prepared by object.
Background technology
Health and disease be the problem of whole society all pays special attention to, it be related to everyone, each family it is personal Interests.Ensure health be not focus on it is ill go to control, but focus on and disease-free first prevent." preventiveing treatment of disease " be traditional Chinese medicine and pharmacy core concept it One and prevention with Chinese medicine health care most important theories basis and criterion.Country proposes from " treatment disease " to " prevention disease " Change, the variation of this health maintenance theory and the dominant ideas that the traditional Chinese medical science is preventiveed treatment of disease are closely bound up.《The Yellow Emperor's Canon of Internal Medicine》It says " just Gas memory, heresy can not be done ", healthy tendency is the immunity of human body, and the immunity of human body is protected from environmental very big, as diet, sleep, Movement, pressure etc..With people's work and the accelerating rhythm of life, a big chunk herd immunity is allowed to decline, immunity is low Under most directly performance be exactly liable to illness, because of frequent illness, the consumption of body has been aggravated, so generally having a delicate constitution, seeking Support the performances such as bad, apathetic, fatigue and weak, appetite reduction, sleep-disorder, it is sick, having an injection to take medicine has become homely food. It is sick every time to be lot more time to restore, and usually recurrent exerbation.Major disease is if things go on like this easily induced, is even resulted in Cancer.
In addition global environmental quality declines so that the crowd in sub-health state is increased.And with people Improvement of living standard and the attention degree enhancing to personal health problem, more and more people start to focus more on the health of itself Situation.
Invention content
It is prepared the object of the present invention is to provide a kind of Chinese medicine composition of strengthen immunity and using the Chinese medicine composition Strengthen immunity herbal paste.
To realize goal of the invention, the technical solution adopted by the present invention is as follows：
Present invention firstly provides a kind of Chinese medicine compositions of strengthen immunity, by weight, the Chinese medicine composition Bulk pharmaceutical chemicals composition include：0.2-0.4 parts of ginseng, 1-2 parts of Chinese torreyanut, 2-4 parts of almond, 4-8 parts of wild jujube, 4-8 parts of mulberries, pallas pit viper 0.2-0.4 parts, 1-4 parts of Chinese yam, 0.5-2 parts of arillus longan, 2-8 parts of dateplum persimmon, 0.4-2.4 parts of bitter orange flower, 2-8 parts of hawthorn, matrimony vine 1-4 Part, 1-4 parts of Longstamen Onion Bulb, 0.4-2.4 parts of dark plum, 2-8 parts of jujube, 0.4-4 parts of hoveniae semoveniae semen, 0.2-1.2 parts of fennel seeds, Chinese cassia tree 0.4-4 1-5 parts of part and donkey-hide gelatin.
The preparation method of above-mentioned Chinese medicine composition, includes the following steps：(1) it is formed by the bulk pharmaceutical chemicals of above-mentioned Chinese medicine composition Each bulk pharmaceutical chemicals are weighed, the other compositions in bulk pharmaceutical chemicals in addition to donkey-hide gelatin are mixed, mixture is obtained, water is added in into mixture, (soaking time is preferably 2-3h) fully is impregnated, is then extracted, is filtered, concentration, obtaining just cream, (relative density of first cream is 1.15-1.18)；(2) it is heated after mixing donkey-hide gelatin and suitable quantity of water, until donkey-hide gelatin is completely dissolved, obtains donkey-hide gelatin liquid；(3) by Ah Glue and the mixing of first cream, then suitable quantity of water is added to be uniformly mixed, then it is concentrated into thick paste；Up to Chinese medicine composition.
According to above-mentioned preparation method, it is preferable that the mass ratio of mixture and water is 1 in step (1)：(8-12).
According to above-mentioned preparation method, it is preferable that the temperature extracted described in step (1) is 100 DEG C.
According to above-mentioned preparation method, it is preferable that the number extracted described in step (1) be 2-3 times, extract every time when Between be 40-180min.
According to above-mentioned preparation method, it is preferable that the temperature concentrated described in step (1) is 60-75 DEG C；The thick paste exists Relative density at 60 DEG C is 1.15-1.18.
According to above-mentioned preparation method, it is preferable that the mass ratio of donkey-hide gelatin and water is 1 in step (2)：(3-6).
According to above-mentioned preparation method, it is preferable that the temperature concentrated described in step (3) is 60-75 DEG C；The thick paste exists Relative density at 60 DEG C is 1.28-1.32.
The Chinese medicine composition of the present invention has effects that improve immunity have effects that strengthen immunity available for preparing Product.
It is the effect of each bulk pharmaceutical chemicals in Chinese medicine composition of the present invention：
Ginseng is the dry root of Araliaceae ginseng, is the rare Chinese medicinal herbs in China,《Sheng Nong's herbal classic》It records, people Ginseng have " tonifying five zang organs, by spirit, determine soul, stop palpitate with fear, remove pathogenic factor, improving eyesight, happy intelligence development " the effect of.Pharmacological research shows people Ginseng can adjust the physiological function of central nervous system, improve body's immunity, and marrow is protected and stimulated to cardiac stimulant, Hemorrhagic shock Hematopoiesis function increases cortex hormone of aadrenaline secretion, adjusts blood glucose level, significantly inhibit the absorption of cholesterol, antitumor, delays Aging, strengthens the adaptability of body, and extract can be obviously promoted the synthesis of rat organ's nucleic acid and protein.And modern doctor Learning proves, ginseng, which has, adjusts central nervous system, Auto-regulator metabolism, enriching the blood and tonifying qi and other effects.
Chinese torreyanut is the dry mature seed of taxaceae plant Chinese torreya；It is sweet in flavor, mild-natured, return lung, stomach, large intestine channel；With desinsection The effect of disperse accumulation moistens the lung and relieve the cough, moistening dryness for relaxing bowels；It is mainly used for hookworm disease, roundworm disease, taeniasis, abdominal pain due to enterositosis, infantile malnutrition, The treatment of the illnesss such as xeropulmonary cough, constipation.
Seed of the almond for rose family apricot, bitter, slightly warm in nature；With it is relieving cough and asthma, relax bowel, hypoglycemic, reducing blood lipid And other effects；For illnesss such as cough and asthma, fullness sensation in chest abundant expectoration, the withered, dry constipation of intestines in deficiency of blood Tianjin.Pharmacological research shows almond energy liver protection, It is relieving cough and asthma, it relaxes bowel, roundworm is killed in antitumor, anti-inflammatory, anticancer, anti-mutation.
Wild jujube is sweet in flavor, mild-natured, has nourishing the liver, and calming heart calms and calms the nerves, and arrest sweating and other effects medically commonly uses it to treat god Through weak, vexed insomnia, dreaminess, night sweat, easily frightened etc. illnesss, meanwhile, and certain strengthening by means of tonics effect can be reached；It is taste void The good health nutrient of the patients such as weak, insufficiency of vital energy and blood, lassitude, insomnia and dreamful sleep.
Mulberries are sweet in flavor and cold in property, have liver-kidney tonifying, nourishing yin and supplementing blood, fluid dryness, UFA eyesight, enhancing immune function, delay Solution and treatment anemia and other effects.Pharmacological research shows that mulberries can enhance immune function；Reduce Na+-K+-ATP enzymatic activitys.And And modern study confirms, abundant activated protein, vitamin, amino acid, carrotene, minerals, white is contained in mulberries fruit The compositions such as veratryl alcohol, anthocyanidin, nutrition are 5~6 times of apple, are 4 times of grape, have multiple efficacies, are described as by medical field " the best health fruit of 21 century ", body immunity can be significantly improved by often eating mulberries, had and slowed down aging, the work(of beautifying face and moistering lotion Effect.
Pallas pit viper removes the entirety of internal organ for Viperidae animal pallas pit viper, and sweet in flavor, warm-natured, returns spleen, Liver Channel have wind-dispelling, dredging collateral, stop Bitterly, the effect of detoxifying；It is usually used in the illnesss such as arthralgia pain due to rheumatism, leprosy, scrofula, boil, mange, haemorrhoids, tumour.
Chinese yam be Dioscoreaceae plant Chinese yam dry rhizome, sweet in flavor, mild-natured, returns spleen, lung, kidney channel；With tonifying spleen nourishing the stomach, promote the production of body fluid The effect of beneficial lung, puckery smart kidney tonifying；It is mainly used under spleen deficiency, chronic diarrhea, the deficiency syndrome of the lung, kidney deficiency, band, the treatment of the illnesss such as frequent micturition.Modern medicine Reason result of the test shows there is promotion union, hypoglycemic, the effects that enhancing immune function, enhance digestive system function.
Aril of the arillus longan for sapindaceous plant longan, sweet in flavor, warm-natured, the thoughts of returning home, the spleen channel；With tonifying heart and spleen, support The effect of blood and tranquilizing mind；It is mainly used for the illnesss such as insufficiency of vital energy and blood, palpitation and severe palpitation, forgetful insomnia, blood deficiency chlorosis.Pharmacological research shows Arillus longan being capable of antibacterial, calm, stomach invigorating, antifatigue.The MAO-B activity that liquid energy inhibits mouse brain (liver) is extracted, there is anti-aging work With；Aqueous extracts in vitro have inhibiting effect to Austria Du small gemma tinea bacterium of Ang Shi；Decocting liquid has inhibiting effect to shigella dysenteriae.
Dateplum persimmon, the scientific name fruit of date plum is warm-natured sweet in flavor, enters taste warp, has nourishing stomach and spleen, tonifying middle-Jiao and Qi, nourishing blood and tranquilization, the profit heart Lung, improving eyesight and other effects are chiefly used in enriching blood and as conditioning drug.Dateplum persimmon is rich in protein, carbohydrate, organic acid, vitamin B and dimension Raw element E and phosphorus, calcium, iron etc. are micro-, all helpful to slowing down aging, enhancing body energy, beautifying face and moistering lotion.
Bitter orange flower cold nature, bitter, acid have the effect of wide chest of qi-regulating, regulating the qi flowing in the channels is soothing the liver, appetizing preventing or arresting vomiting, helps digestion, resolving sputum, Cure mainly the bored distending pain of chest and abdomen, accumulation of food in the stomach and intes tine due to indigestion, phlegm and retained fluid, rectal prolapse, the chest side of body not symptoms such as easypro, nausea and vomiting, do not feel like eating.Modern medicine is demonstrate,proved Bright, it has the function of cardiac stimulant, diuresis, calmness and reducing heart rate, can reduce the excitability of nervous system and spinal reflex function It is hyperfunction, for acute disease and chronic cardiac insufficiency.Congestive heart failure, cardiac edema and atrial fibrillation is cured mainly to quiver It is dynamic, share the therapeutic effect that can strengthen to epileptics with silver bromide.
Hawthorn is the dry mature fruit of rose family hawthorn or large-fruited Chinese hawthorn, sour, sweet, slightly warm in nature, returns spleen, stomach, Liver Channel；Tool There are digestion-promoting spleen-invigorating, scattered stasis effect；Be mainly used for meat stagnation, gastral cavilty account full, diarrhea dysentery abdominal pain, blood stasis closed, postpartum stasis, The illnesss such as confidant sting, hernia are had a pain, hyperlipemia.
Ripening fruits of the matrimony vine for matrimony vine of solanaceae plant, mild-natured, sweet in flavor, return liver warp, kidney channel；With nourishing liver and kidney, strengthening the essence The effect of improving eyesight；Pharmacological research shows that matrimony vine can enhance immune function, anti-aging, antitumor, reducing blood lipid, liver protection, promotion Hematopoiesis function, hypoglycemic, blood pressure lowering, inhibits heart and excited enteron aisle etc. to intend choline effect, enhance the resistance to of mouse at anti-genetic damage Hypoxia ability and extend its swimming time.
Bulb of the Longstamen Onion Bulb for liliaceous plant Allium macrostemon or Chinese onion, warm-natured, acrid flavour, hardship, thoughts of returning home warp, lung channel, stomach, large intestine Through；Have effects that activate yang and remove abstruction, promoting the circulation of qi is led stagnant, be mainly used for the illnesss such as chest impediment and cardialgia, epigastric abdominal fullness distending pain, weight after rush down dysentery. Pharmacological research shows that Longstamen Onion Bulb has antiatherosclerosis, and anti-platelet aggregation interferes arachidonic acid metabolic, anti-oxidant, resists The effects that bacterium.
Dark plum is the almost ripe fruit of rose department plant plum, mild-natured, sour, puckery；Return liver warp, the spleen channel, lung channel, large intestine channel； Have effects that astringe the lung, puckery intestines, promote the production of body fluid, claming ascaris, be mainly used for controlling chronic cough of deficiency lung, chronic diarrhea, protracted dysentery, ascariasis of biliary tract abdominal pain, vomiting, abnormal heat It quenches one's thirst, metrostaxis, sore etc..Pharmacological research shows that gallbladder contraction, promotion choleresis can be made, and have anti-protein allergies to make With；There is antibacterial action to various pathogens, also have inhibiting effect to various dermatophytes；There is ascarifuge；Have it is antifatigue, The effects that anti-aging, radioresistance, antagonism calcium ion, enhancing immune function.
The ripening fruits of jujube Rhamnaceae plant jujube, warm-natured, taste warp sweet in flavor have an invigorating spleen and reinforcing stomach, tonifying middle-Jiao and Qi, blood-nourishing The function of tranquilizing the mind；It is mainly used for controlling spleen eating less, qi-blood-body fluid deficiency, weak loose stool, hysteria of womam.Modern pharmacological research table It is bright, jujube have central inhibitory action, protect liver, enhancing muscular strength, antiallergic action, antifatigue, antitumor, calm peace, increase it is white thin Born of the same parents cAMP, enhance the functions such as immune.
Hoveniae semoveniae semen is the mature seed of Rhamnaceae plant trifoliate orange Dulcis, mild-natured, sweet in flavor；Return stomach；With relieving restlessness of quenching the thirst, clear wet Heat, relieving alcoholism and other effects；It is mainly used for controlling polydipsia to vomit inverse, difficulty in urination and defecation etc..During pharmacological research shows that hoveniae semoveniae semen can inhibit Pivot, decompression, anti peroxidation of lipid enhance synthetic physical ability.Pharmacological evaluation shows there is significant diuresis to rabbit, and nothing is appointed What side effect.
Fruit of the fennel seeds for samphire fennel, warm-natured, acrid flavour；Return liver warp, the spleen channel, stomach, kidney channel；With dispelling cold The effect of analgesic, regulating qi-flowing for harmonizing stomach；For treating cold hernia stomachache, the testis swelling and hanging down of either of the testes, through abdominal pain of trembling with fear.Pharmacological research shows fennel seeds energy Promote gastrointestinal peristalsis, antiulcer, cholagogic, relax tracheal smooth muscle, has gonadotropic Effect, maincenter paralysis is antibacterial, antitumor Effect.
Chinese cassia tree is the dry bark of canella Chinese cassia tree, extremely hot in nature, acrid flavour, sweet；Return kidney channel, the spleen channel, the heart channel of Hang-Shaoyin, Liver Channel； There is mends fire supporing yang, guiding fire to origin, eliminating cold to stop pain, warming meridian；For impotence Gong Leng, waist and knee crymodynia, deficiency of the kidney and dyspnea, The illnesss such as deficient yang with upper manifestation, dizziness hot eyes, trusted subordinate's crymodynia, cold of insufficiency type vomiting and diarrhea, cold hernia stomachache, dysmenorrhoea Amenorrhea.Pharmacological research shows Chinese cassia tree There is the stimulation of mitigation to stomach, and gastrointestinal smooth muscle spasmus can be released, there is very strong anti-ulcer effect；Can antagonism blood it is small Plate is assembled, and has the function of to improve cardiovascular system, adjusts body's immunity；Central nervous system has calm, town Bitterly, the effects that antipyretic, anticonvulsion；There are prevention and protective effect to the deficiency of yang, yin-deficient model；With certain anti-inflammatory effect；Have Very strong fungicidal action；It is antitumor；Raising mice serum triacylglycerol is substantially reduced effect, can extend sodium nitrite poisoning The time-to-live of mouse.
Donkey-hide gelatin for equid donkey skin through decocting, concentrating manufactured solid gum, it is sweet in flavor, it is mild-natured；Channel tropism return lung, liver, kidney Through；Major function is enriched blood enriching yin, is moisturized, and is stopped blooding.For blood deficiency chlorosis, dizziness palpitaition, impotence weakness, dysphoria and insomnia, in empty wind It is dynamic, xeropulmonary cough, overstrain cough spitting of blood, haematemesis hematuria, uterine bleeding of having blood in stool, vaginal bleeding during pregnancy.
The present invention also provides a kind of herbal paste of strengthen immunity, the herbal paste of the strengthen immunity includes above-mentioned enhancing Chinese medicine composition, collagen peptide, brown sugar and the honey of immunity；The Chinese medicine composition, collagen peptide, brown sugar and honey Mass ratio be 1：(0.1-2)：(0.1-0.5)：(0.1-0.6).
According to the herbal paste of above-mentioned strengthen immunity, it is preferable that the herbal paste of the strengthen immunity further includes preservative, institute The mass ratio for stating preservative and Chinese medicine composition is (0.0004-0.0008)：1.It is further preferred that the preservative is sorbic acid Potassium.
According to the herbal paste of above-mentioned strengthen immunity, it is preferable that the herbal paste of the strengthen immunity further includes sweetener, institute The mass ratio for stating sweetener and Chinese medicine composition is (0.0002-0.0012)：1.It is further preferred that the sweetener is trichlorine sugarcane Sugar.
According to the herbal paste of above-mentioned strengthen immunity, it is preferable that the collagen peptide is ox bone collagen protein peptides, ox-hide Collagen peptide, fish bone collagen protein peptides, collagen peptide, collagen peptide, pig bone collagen peptide, pig skin gelatin At least one of former protein peptides.
The present invention also provides a kind of preparation methods of the herbal paste of above-mentioned strengthen immunity, include the following steps：
(1) each bulk pharmaceutical chemicals are weighed by the bulk pharmaceutical chemicals of the Chinese medicine composition of above-mentioned strengthen immunity composition, will be removed in bulk pharmaceutical chemicals Other compositions mixing other than donkey-hide gelatin, obtains mixture, water is added in into mixture, and fully (soaking time is preferably 2- for immersion 3h), it then extracts, filters, concentration obtains just cream (relative density of first cream is 1.15-1.18)；
(2) it is heated after mixing donkey-hide gelatin and suitable quantity of water, until donkey-hide gelatin is completely dissolved, obtains donkey-hide gelatin liquid；
(3) donkey-hide gelatin liquid and first cream are mixed, then suitable quantity of water is added to be uniformly mixed, be then concentrated into thick paste；Up to Chinese medicine Composition；
(4) it is 1 in mass ratio by Chinese medicine composition, collagen peptide, brown sugar and honey under the conditions of 90-110 DEG C： (0.1-2)：(0.1-0.5)：(0.1-0.6) is uniformly mixed, then through filling, sterilization treatment up to the herbal paste of strengthen immunity.
According to above-mentioned preparation method, it is preferable that the mass ratio of mixture and water is 1 in step (1)：(8-12).
According to above-mentioned preparation method, it is preferable that the temperature extracted described in step (1) is 100 DEG C.
According to above-mentioned preparation method, it is preferable that the number extracted described in step (1) be 2-3 times, extract every time when Between be 40-180min.
According to above-mentioned preparation method, it is preferable that the temperature concentrated described in step (1) is 60-75 DEG C；The just cream exists Relative density at 60 DEG C is 1.15-1.18.
According to above-mentioned preparation method, it is preferable that the mass ratio of donkey-hide gelatin and water is 1 in step (2)：(3-6).
According to above-mentioned preparation method, it is preferable that the addition of water is donkey-hide gelatin liquid and first cream gross mass in step (3) 15%-40%.
According to above-mentioned preparation method, it is preferable that the temperature concentrated described in step (3) is 60-75 DEG C；The thick paste exists Relative density at 60 DEG C is 1.28-1.32.
According to above-mentioned preparation method, it is preferable that sterilizing described in step (4) is moist heat sterilization, and sterilising conditions are：115 DEG C sterilizing 20min.
The positive beneficial effect that the present invention obtains is：
(1) contain ginseng, Chinese yam, the hoveniae semoveniae semen of tonifying middle-Jiao and Qi in the Chinese medicine composition of strengthen immunity of the present invention；Simultaneously Also containing donkey-hide gelatin, longan, the jujube enriched blood, then it is aided with the matrimony vine of enriching yin and nourishing kidney, mulberries, qi-regulating is in, strengthening the spleen and stomach is digestant Hawthorn, dried orange peel, Chinese torreyanut, bitter orange flower, fennel seeds, Longstamen Onion Bulb etc. along with Chinese cassia tree, dark plum, almond and can supplement human body and cannot close Into and required 8 kinds of amino acid pallas pit viper, prescription is rigorous, and compatibility is accurate, from source of generating QI and blood come coordinate human body gas, blood, the moon, The balance of sun enhances immunity of organisms.
(2) herbal paste of strengthen immunity of the invention is by the Chinese medicine composition of strengthen immunity, honey, brown sugar and small point The collagen active peptide of son compounds, and has the work(for adjusting human body gas, blood, the balance of yin, yang and enhancing matrix immunity Effect, moreover, can also supplement the nutriments such as the amino acid of human body loss rapidly containing micromolecular collagen active peptide, improve Cell metabolism has cell targeting repair, so as to repair impaired body, improves physical condition, enhancing body is exempted from Epidemic disease power and resistance.In addition, the herbal paste of the strengthen immunity of the present invention is under powerless, decreased energy of speaking, easy fatigue, appetite Drop, soreness of waist and knee, weak on his pins, sexual hypoesthesia, dizziness and tinnitus, uneasy sleeping at night or slightly quiet i.e. tired, repeated cold are easily sick, after being ill The malaise symptoms such as refractory and postoperative have good improvement result.
(3) the herbal paste preparation method of strengthen immunity of the invention is simple, easy to operate, can mass produce.
Specific embodiment
Below by way of specific embodiment, the present invention will be further described in detail, but is not intended to limit the model of the present invention It encloses.Without departing from the spirit and substance of the case in the present invention, the modifications or substitutions made to the method for the present invention, step or condition, It all belongs to the scope of the present invention.
Unless otherwise specified, the conventional means that technological means used in embodiment is well known to those skilled in the art, Reagent used is also this field conventional reagent.
Embodiment 1：
A kind of Chinese medicine composition of strengthen immunity, by weight, the bulk pharmaceutical chemicals composition of the Chinese medicine composition include： 0.3 part of ginseng, 1.5 parts of Chinese torreyanut, 3 parts of almond, 6 parts of wild jujube, 7 parts of mulberries, 0.3 part of pallas pit viper, 2.5 parts of Chinese yam, 1.2 parts of arillus longan, It is 5 parts of dateplum persimmon, 1.5 parts of bitter orange flower, 5 parts of hawthorn, 3 parts of matrimony vine, 2 parts of Longstamen Onion Bulb, 1.2 parts of dark plum, 6 parts of jujube, 2.5 parts of hoveniae semoveniae semen, small 4 parts of 0.8 part of fennel, 2.5 parts of Chinese cassia tree and donkey-hide gelatin.
The preparation method of above-mentioned Chinese medicine composition is：
(1) each bulk pharmaceutical chemicals are weighed by the bulk pharmaceutical chemicals of above-mentioned Chinese medicine composition composition, by its in bulk pharmaceutical chemicals in addition to donkey-hide gelatin The mixing of his ingredient, obtains mixture, adds in water into mixture, and the mass ratio of mixture and water is 1：10, fully impregnate after First time extraction, extraction time 3h are carried out at 100 DEG C, filtering obtains filtrate；It is 1 by the mass ratio of filter residue and water：10 ratio Example adds in water into filter residue, and second is carried out at 100 DEG C and is extracted, and extraction time 2h, filtering obtains filtrate；Then again to The water of its 10 times of quality is added in filter residue, third time extraction, extraction time 1h are carried out at 100 DEG C, filtering obtains filtrate； The filtrate extracted three times is merged, is concentrated, obtains just cream；(2) it is heated after mixing donkey-hide gelatin and suitable quantity of water, until donkey-hide gelatin It is completely dissolved, obtains donkey-hide gelatin liquid；(3) donkey-hide gelatin liquid and first cream are mixed, then suitable quantity of water is added to be uniformly mixed, it is then dense at 60 DEG C It is reduced to the thick paste that relative density is 1.28-1.32；Up to Chinese medicine composition.
Embodiment 2：
A kind of Chinese medicine composition of strengthen immunity, by weight, the bulk pharmaceutical chemicals composition of the Chinese medicine composition include： 0.4 part of ginseng, 1 part of Chinese torreyanut, 2 parts of almond, 4 parts of wild jujube, 6 parts of mulberries, 0.4 part of pallas pit viper, 2 parts of Chinese yam, 1 part of arillus longan, dateplum persimmon 2 Part, 0.4 part of bitter orange flower, 2 parts of hawthorn, 4 parts of matrimony vine, 1 part of Longstamen Onion Bulb, 2 parts of dark plum, 2 parts of jujube, 4 parts of hoveniae semoveniae semen, 1 part of fennel seeds, 2 parts of 1 part of Chinese cassia tree and donkey-hide gelatin.
The preparation method of above-mentioned Chinese medicine composition is：
(1) by the bulk pharmaceutical chemicals of above-mentioned Chinese medicine composition composition weigh each bulk pharmaceutical chemicals, by bulk pharmaceutical chemicals in addition to donkey-hide gelatin Other compositions mix, and obtain mixture, add in water into mixture, and the mass ratio of mixture and water is 1：12, after fully impregnating First time extraction, extraction time 3h are carried out at 100 DEG C, filtering obtains filtrate；It is 1 by the mass ratio of filter residue and water：12 Ratio adds in water into filter residue, and second is carried out at 100 DEG C and is extracted, and extraction time 2h, filtering obtains filtrate；Then again The water of its 12 times of quality is added in into filter residue, third time extraction, extraction time 1h are carried out at 100 DEG C, filtering is filtered Liquid；The filtrate extracted three times is merged, is concentrated, obtains just cream；(2) donkey-hide gelatin and suitable quantity of water are mixed and heated, until Ah Glue is completely dissolved, and obtains donkey-hide gelatin liquid；(3) donkey-hide gelatin liquid and filtrate are mixed, then suitable quantity of water is added to be uniformly mixed, then at 60 DEG C It is concentrated into the thick paste that relative density is 1.28-1.32；Up to Chinese medicine composition.
Embodiment 3：
A kind of Chinese medicine composition of strengthen immunity, by weight, the bulk pharmaceutical chemicals composition of the Chinese medicine composition include： 0.2 part of ginseng, 1 part of Chinese torreyanut, 4 parts of almond, 8 parts of wild jujube, 6 parts of mulberries, 0.2 part of pallas pit viper, 4 parts of Chinese yam, 0.5 part of arillus longan, dateplum persimmon 8 Part, 2 parts of bitter orange flower, 8 parts of hawthorn, 3 parts of matrimony vine, 1 part of Longstamen Onion Bulb, 0.4 part of dark plum, 8 parts of jujube, 0.4 part of hoveniae semoveniae semen, fennel seeds 0.2 1 part of part, 4 parts of Chinese cassia tree and donkey-hide gelatin.
The preparation method of above-mentioned Chinese medicine composition is：
(1) by the bulk pharmaceutical chemicals of above-mentioned Chinese medicine composition composition weigh each bulk pharmaceutical chemicals, by bulk pharmaceutical chemicals in addition to donkey-hide gelatin Other compositions mix, and obtain mixture, add in water into mixture, and the mass ratio of mixture and water is 1：8, fully impregnate after First time extraction, extraction time 3h are carried out at 100 DEG C, filtering obtains filtrate；It is 1 by the mass ratio of filter residue and water：8 ratio Example adds in water into filter residue, and second is carried out at 100 DEG C and is extracted, and extraction time 2h, filtering obtains filtrate；It will carry twice The filtrate taken merges, and is concentrated, and obtains just cream；(2) donkey-hide gelatin and suitable quantity of water are mixed and heated, until donkey-hide gelatin is completely dissolved, Obtain donkey-hide gelatin liquid；(3) donkey-hide gelatin liquid and filtrate are mixed, then suitable quantity of water is added to be uniformly mixed, be then concentrated at 60 DEG C opposite Density is the thick paste of 1.28-1.32；Up to Chinese medicine composition.
Embodiment 4：
A kind of Chinese medicine composition of strengthen immunity, by weight, the bulk pharmaceutical chemicals composition of the Chinese medicine composition include： 0.3 part of ginseng, 2 parts of Chinese torreyanut, 2 parts of almond, 5 parts of wild jujube, 8 parts of mulberries, 0.3 part of pallas pit viper, 3 parts of Chinese yam, 2 parts of arillus longan, dateplum persimmon 4 Part, 2.4 parts of bitter orange flower, 3 parts of hawthorn, 1 part of matrimony vine, 3 parts of Longstamen Onion Bulb, 1 part of dark plum, 4 parts of jujube, 3 parts of hoveniae semoveniae semen, fennel seeds 1.2 5 parts of part, 0.4 part of Chinese cassia tree and donkey-hide gelatin.
The preparation method of above-mentioned Chinese medicine composition is same as Example 1.
Embodiment 5：
A kind of Chinese medicine composition of strengthen immunity, by weight, the bulk pharmaceutical chemicals composition of the Chinese medicine composition include： It is 0.4 part of ginseng, 1.5 parts of Chinese torreyanut, 3 parts of almond, 6 parts of wild jujube, 4 parts of mulberries, 0.2 part of pallas pit viper, 1 part of Chinese yam, 1.5 parts of arillus longan, black 5 parts of jujube, 1 part of bitter orange flower, 3 parts of hawthorn, 2 parts of matrimony vine, 2 parts of Longstamen Onion Bulb, 1 part of dark plum, 6 parts of jujube, 2.5 parts of hoveniae semoveniae semen, fennel seeds 4 parts of 0.8 part, 2 parts of Chinese cassia tree and donkey-hide gelatin.
The preparation method of above-mentioned Chinese medicine composition is same as Example 1.
Embodiment 6：
A kind of Chinese medicine composition of strengthen immunity, by weight, the bulk pharmaceutical chemicals composition of the Chinese medicine composition include： 0.4 part of ginseng, 2 parts of Chinese torreyanut, 4 parts of almond, 8 parts of wild jujube, 8 parts of mulberries, 0.4 part of pallas pit viper, 4 parts of Chinese yam, 2 parts of arillus longan, dateplum persimmon 8 Part, 2.4 parts of bitter orange flower, 8 parts of hawthorn, 4 parts of matrimony vine, 4 parts of Longstamen Onion Bulb, 2.4 parts of dark plum, 8 parts of jujube, 4 parts of hoveniae semoveniae semen, fennel seeds 1.2 5 parts of part, 4 parts of Chinese cassia tree and donkey-hide gelatin.
The preparation method of above-mentioned Chinese medicine composition is same as Example 1.
Embodiment 7：
A kind of Chinese medicine composition of strengthen immunity, by weight, the bulk pharmaceutical chemicals composition of the Chinese medicine composition include： It is 0.2 part of ginseng, 1.2 parts of Chinese torreyanut, 2.5 parts of almond, 5 parts of wild jujube, 7 parts of mulberries, 0.3 part of pallas pit viper, 3 parts of Chinese yam, 1 part of arillus longan, black 5 parts of jujube, 1.5 parts of bitter orange flower, 4 parts of hawthorn, 3 parts of matrimony vine, 2 parts of Longstamen Onion Bulb, 1 part of dark plum, 5 parts of jujube, 2 parts of hoveniae semoveniae semen, fennel seeds 0.5 3 parts of part, 2.5 parts of Chinese cassia tree and donkey-hide gelatin.
The preparation method of above-mentioned Chinese medicine composition is same as Example 1.
Embodiment 8：
A kind of Chinese medicine composition of strengthen immunity, by weight, the bulk pharmaceutical chemicals composition of the Chinese medicine composition include： 0.3 part of ginseng, 1 part of Chinese torreyanut, 2 parts of almond, 6 parts of wild jujube, 5 parts of mulberries, 0.3 part of pallas pit viper, 3 parts of Chinese yam, 2 parts of arillus longan, dateplum persimmon 4 Part, 2 parts of bitter orange flower, 6 parts of hawthorn, 4 parts of matrimony vine, 2.5 parts of Longstamen Onion Bulb, 1.5 parts of dark plum, 6 parts of jujube, 1 part of hoveniae semoveniae semen, fennel seeds 1 4 parts of part, 1 part of Chinese cassia tree and donkey-hide gelatin.
The preparation method of above-mentioned Chinese medicine composition is same as Example 3.
Embodiment 9：
A kind of herbal paste of strengthen immunity, the herbal paste of the strengthen immunity is by Chinese medicine composition described in embodiment 1, glue Former protein peptides, brown sugar and honey are prepared；The Chinese medicine composition, collagen peptide, brown sugar and honey mass ratio be 1： 1：0.25：0.3；The collagen peptide is ox bone collagen protein peptides.
The preparation method of the herbal paste of above-mentioned strengthen immunity is：Under the conditions of 100 DEG C, by Chinese medicine composition, collagen Peptide, brown sugar and honey are uniformly mixed by its defined mass ratio, then filling by 15g/ bags of progress, then in 115 DEG C of sterilizings 20min to get strengthen immunity herbal paste.
The instructions of taking of the herbal paste of strengthen immunity of the present invention is：By batheroom scale, dose 0.5g/kg uses 100ml It is taken orally after water dilution, daily once.
Embodiment 10：
The content of embodiment 10 is substantially the same manner as Example 9, the difference is that：The Chinese medicine composition, collagen egg The mass ratio of white peptide, brown sugar and honey is 1：1.5：0.1：0.3；The collagen peptide is cow leather collagen peptide.
The preparation method of the herbal paste of the strengthen immunity is substantially the same manner as Example 9, the difference is that：At 90 DEG C Under the conditions of, Chinese medicine composition, collagen peptide, brown sugar and honey are uniformly mixed by defined mass ratio.
Embodiment 11：
The content of embodiment 11 is substantially the same manner as Example 9, the difference is that：The Chinese medicine composition, collagen egg The mass ratio of white peptide, brown sugar and honey is 1：0.1：0.5：0.6；The collagen peptide is fish bone collagen protein peptides.
The preparation method of the herbal paste of the strengthen immunity is substantially the same manner as Example 9, the difference is that：110 Under the conditions of DEG C, Chinese medicine composition, collagen peptide, brown sugar and honey are uniformly mixed by defined mass ratio.
Embodiment 12：
The content of embodiment 12 is substantially the same manner as Example 9, the difference is that：The Chinese medicine composition, collagen egg The mass ratio of white peptide, brown sugar and honey is 1：2：0.25：0.1；The collagen peptide is fish bone collagen protein peptides.
Embodiment 13：
The content of embodiment 13 is substantially the same manner as Example 9, the difference is that：The Chinese medicine composition, collagen egg The mass ratio of white peptide, brown sugar and honey is 1：0.5：0.3：0.6；The collagen peptide is collagen peptide.
Embodiment 14：
The content of embodiment 14 is substantially the same manner as Example 9, the difference is that：The Chinese medicine composition is embodiment 2 Chinese medicine compositions prepared；The collagen peptide is collagen peptide.
Embodiment 15：
The content of embodiment 15 is substantially the same manner as Example 11, the difference is that：The Chinese medicine composition is implements Chinese medicine composition prepared by example 3；The collagen peptide is pig bone collagen peptide.
Embodiment 16：
The content of embodiment 16 is substantially the same manner as Example 12, the difference is that：The Chinese medicine composition is implements Chinese medicine composition prepared by example 4；The collagen peptide is pigskin collagen peptides.
Embodiment 16：
The content of embodiment 16 is substantially the same manner as Example 13, the difference is that：The Chinese medicine composition is implements Chinese medicine composition prepared by example 5；The collagen peptide is collagen peptide.
Embodiment 17：
The content of embodiment 17 is substantially the same manner as Example 10, the difference is that：The Chinese medicine composition is implements Chinese medicine composition prepared by example 6；The collagen peptide is pigskin collagen peptides.
Embodiment 18：
The content of embodiment 18 is substantially the same manner as Example 12, the difference is that：The Chinese medicine composition is implements Chinese medicine composition prepared by example 7；The collagen peptide is ox bone collagen protein peptides.
Embodiment 19：
The content of embodiment 19 is substantially the same manner as Example 9, the difference is that：The Chinese medicine composition is embodiment 8 Chinese medicine compositions prepared；The collagen peptide is fish bone collagen protein peptides.
Embodiment 20：
A kind of herbal paste of strengthen immunity, the herbal paste of the strengthen immunity is by Chinese medicine composition described in embodiment 1, glue Former protein peptides, brown sugar, honey, sweetener and preservative are prepared；The Chinese medicine composition, collagen peptide, brown sugar, bee The mass ratio of honey, sweetener and preservative is 1：1：0.25：0.3：0.0012： 0.0008；The collagen peptide is bone glue Former protein peptides；The sweetener is Sucralose；The preservative is potassium sorbate.
The preparation method of the herbal paste of above-mentioned strengthen immunity is：Under the conditions of 100 DEG C, by Chinese medicine composition, collagen Peptide, brown sugar, honey, sweetener and preservative are uniformly mixed by its defined mass ratio, then filling by 15g/ bags of progress, so Sterilize herbal pastes of the 20min to get strengthen immunity at 115 DEG C afterwards.
Embodiment 21：
The content of embodiment 21 is substantially the same manner as Example 20, the difference is that：The Chinese medicine composition, collagen egg The mass ratio of peptide, brown sugar, honey, sweetener and preservative is 1 in vain：1：0.25：0.3：0.0002： 0.0004；The collagen egg White peptide is fish bone collagen protein peptides.
Embodiment 22：
The content of embodiment 22 is substantially the same manner as Example 20, the difference is that：The Chinese medicine composition, collagen egg The mass ratio of peptide, brown sugar, honey, sweetener and preservative is 1 in vain：1：0.25：0.3：0.0002： 0.0004；The collagen egg White peptide is fish bone collagen protein peptides.
Embodiment 23：The effect of herbal paste of strengthen immunity of the present invention, is studied
Zoopery is carried out by taking the herbal paste of strengthen immunity prepared by embodiment 9 as an example, studies strengthen immunity of the present invention Herbal paste the effect of.
1st, experiment material
1.1 experimental animal
Rabbit, male, weight 5-8kg, purchased from Traditional Chinese Medicine University Of Guangzhou experimental center.
1.2 experimental drug
The herbal paste of strengthen immunity prepared by the present embodiment 9.
1.3 main agents and instrument
Physiological saline, Hank ' s solution, RPMI1640 culture solutions, antibiotic (penicillin, streptomysin), calf serum, 1% Glacial acetic acid, protease (trypsase), phosphate buffer (pH7.2-7.4), production factor, 1mol/L hydrochloric acid solutions, MTT, silk floss Positive red blood cell (SRBC), Tric-HCL buffer solutions (pH8.2), agarose, methanol, concanavalin A, Giemsa dye liquors etc..
Electronic balance (thousand points), electronic balance (percentage), spectrophotometer, carbon dioxide incubator, low speed centrifuge, perseverance Warm water bath, microscope, inverted microscope, microplate reader, spiral micrometer, superclean bench, sterile scalpel, tweezers, injection Device (25ul), cell counter, glassware, the flat tissue culture plate in 24 holes and 96 holes, sterile gauze, test tube (10ml, 25ml), timer, culture dish, thermostatic drying chamber, glass slide.
2nd, experimental method
2.1 animal packet
The rabbit that weight is 5-8kg is grouped at random, is divided into blank control group, experiment 1 group (low dose group), experiment 2 groups (middle dose groups) and experiment 3 groups (high dose groups), every group 60.
2.3 dosage
(1) 1 group (low dose group) is tested：The herbal paste of strengthen immunity prepared by the embodiment of the present invention 9 is fed, is given by weight Medicine, dosage 0.25g/kg take orally after being diluted with 100ml water, (based on human body weight 60kg, convert people's by daily single Taking dose is 0.25g/kg)；Experiment is further divided into 4 groups, each group 15 for 1 group.
(2) 2 groups (middle dose groups) are tested：The herbal paste of strengthen immunity prepared by the embodiment of the present invention 9 is fed, is given by weight Medicine, dosage 0.5g/kg take orally after being diluted with 100ml water, (based on human body weight 60kg, convert the clothes of people by daily single It is 0.5g/kg with dosage)；Experiment is further divided into 4 groups, each group 15 for 2 groups.
(3) 3 groups (high dose groups) are tested：The herbal paste of strengthen immunity prepared by the embodiment of the present invention 9 is fed, is given by weight Medicine, dosage 0.75g/kg take orally after being diluted with 100ml water, (based on human body weight 60kg, convert people's by daily single Taking dose is 0.75g/kg)；Experiment is further divided into 4 groups, each group 15 for 3 groups.
(4) blank control group is given isometric distilled water and is freely drunk；Normal group is further divided into 4 groups, often A group 15.
Then internal organs/gravity test, delayed allergy measure, the survey of lymphocyte transformation value are surveyed in continuous feeding 30 days Fixed and NK cytoactive detections.
2.4 criterion
According to 2003 editions《Health food is examined and assessment technique specification》Regulation：In cellular immune function, humoral immunity work( Energy, monocytes/macrophages function, any two aspects of four aspects of NK cell activity are positive, can determine that the given the test agent has and increase Strong immunity.
2.5 Data Processing in Experiment
It is handled with SPSS software datas, using variance analysis.Calculate F values, F values<0.05, each group indifference conspicuousness.F values >=0.05, P<0.05, illustrate that several of group has the notable opposite sex；P<0.01, illustrate there is pole significant difference.
3rd, experimental result
3.1 internal organs/weight ratio measurement
After rabbit is weighed, intravenous injection air is dead, takes spleen and thymus gland, removes most fascia, organ surface is blotted with filter paper Bloodstain is weighed, and is calculated spleen/weight ratio and thymus gland/weight ratio, be the results are shown in Table 1,2.
Influence of the herbal paste of 1 strengthen immunity of the present invention of table to rabbit weight
Influence of the herbal paste of 2 strengthen immunity of the present invention of table to rabbit spleen/weight ratio and thymus gland/weight ratio
As shown in Table 1, after feeding rabbit 30 days using the herbal paste of the strengthen immunity of the present invention of various dose, the body of rabbit There is apparent increase again, illustrate that the herbal paste of strengthen immunity of the present invention has no adverse effects to rabbit weight, it is safe.By table 2 It is found that after feeding rabbit 30 days using the herbal paste of the strengthen immunity of the present invention of various dose, to rabbit spleen/weight ratio (P values are had a significant impact with thymus gland/weight ratio<0.05).
(vola pedis thickens method) is tested in 3.2 delayed allergies (DTH)
Sheep blood is taken, brine 3 times, every rabbit is through being injected intraperitoneally 2% (v/v normal salines) hematocrit SRBC (4000r/min, 10min) 0.2ml, 4d after sensitization, measures left back foot plantar thickness, continuously surveys 3 times, is taken with portion position Value.Then 20% (v/v, with normal saline) hematocrit SRBC 20ul are subcutaneously injected in measuring point, 24 hours after injection Left back foot plantar thickness is measured, the degree of DTH is represented with difference by front and rear foot plantar thickness.The difference of test sample group Higher than the difference of control group, it is believed that this experimental result is positive, and the results are shown in Table 3.
The herbal paste of 3 strengthen immunity of the present invention of table, which takes a stand to rabbit, reacts the influence of (DTH)
As shown in Table 3, after feeding rabbit 30 days using the herbal paste of the strengthen immunity of the present invention of various dose, 2 groups are tested Blank control group is apparently higher than, and difference has conspicuousness (P with 3 groups of rabbit toes swellings of experiment<0.05) it is, but real The difference tested between 2 groups and experiment 3 is not notable.
The rabbit lymphocyte transformation experiment (mtt assay) of 3.3ConA inductions
It is sterile to take spleen, it is put into the small beaker for being contained in appropriate sterile Hank ' s liquid, a small amount of cell, mistake is taken with scissors or tweezers 200 mesh screens, make single cell suspension.Washed 3-5 times, centrifuged 15 minutes with Hank ' s liquid again, after cell is suspended in 1ml's In complete culture solution, microscopy counts, then holes is divided to add in 24 well culture plates splenocyte suspension, and per hole 1ml, another hole adds 75ulConA liquid, another hole put 5% carbon dioxide, 72h are cultivated in 37 DEG C of carbon dioxide incubators as control.Before culture terminates 4h gently sucks supernatant 0.7ml, the RPMI1640 culture solutions without calf serum, while adds in MTT50ul/ holes, continues to train Support 4h.After culture, 1ml acid isopropyl alcohol is added in per hole, purple crystal is allowed to be completely dissolved.Then liquid is moved into cuvette In, colorimetric estimation, wavelength 570nm. lymphopoiesis ability with plus the OD value in ConA holes subtract and be not added with the light in ConA holes Density value represents lymphopoiesis ability.The optical density difference of given the test agent is significantly higher than the optical density difference of control group, can Judge this experimental result positive.It the results are shown in Table 4.
The influence that the herbal paste of 4 strengthen immunity of the present invention of table tests rabbit lymphocyte transformation
Remarks：* represent that there were significant differences compared with blank control group.
As shown in Table 4, after feeding rabbit 30 days using the herbal paste of the strengthen immunity of the present invention of various dose, 2 groups are tested Blank control group is apparently higher than, and difference has conspicuousness (P with 3 groups of rabbit lymphocyte transformation abilities of experiment<0.05)；But It is that the difference tested between 2 groups and experiment 3 is not notable.
The measure (lactate dehydrogenase L DH measuring methods) of 3.4NK cell activity
First target cell (YAC-1) secondary culture is washed repeatedly, then use RPMI1640 using preceding with Hank ' s before experiment Complete culture solution adjustment cell concentration is 4 × 105/ml.Test rabbits intravenous injection air is lethal, sterile to take spleen, with Hank ' S liquid cleans 2 times, centrifuges 10min every time.Remove supernatant, add sterile water, splitting erythrocyte, add 1mlHank ' s and 8mlHank ' s liquid, centrifugation, then be resuspended with RPMI1640 (10% calf serum 1ml), adjustment cell concentration is 2 × 107/ml, It is 50 to make effect target ratio：1. taking target cell and effect each 100ul of cell, add in U-shaped 96 well culture plate；Target cell Spontaneous release hole adds Target cell and each 100ul of culture solution, target cell maximum release aperture add target cell and each 100ul of 1%NP40.It is above-mentioned each be all provided with three A parallel hole, by 96 orifice plates with 1500r/min, sucks 100ul per hole and is put in flat 96 by 37 DEG C, cultivate 4h in 5% incubator In well culture plate, LDH matrix liquid 100ul are added in, react 3-10min, the hydrochloric acid solution 30ul that 1mol/l is then added in per hole is whole It only reacts, then densitometric value (OD) at microplate reader 490nm, calculates NK cell activity.
NK cell activity (%)=(reacting hole OD- Spontaneous releases hole OD)/(maximum release aperture-Spontaneous release hole OD) × 100
The NK cell activity obtained is converted as the following formula：X=Sin- √ p, P is NK cell activity in formula, is decimally represented.By Test agent group NK cell activity is higher than the NK cell activity of control group, can determine that this experimental result positive, the results are shown in Table 5.
Influence of the herbal paste of 5 strengthen immunity of the present invention of table to NK cell activity
As shown in Table 5, after feeding rabbit 30 days using the herbal paste of the strengthen immunity of the present invention of various dose, 2 groups are tested Rabbit NK cell activity is apparently higher than blank control group, and difference has conspicuousness (P<0.05)；But experiment 1 group and experiment 3 compared with blank control group, and difference is not notable.
The experimental results showed that, the herbal paste of strengthen immunity of the present invention has effects that enhance immunity of organisms above.
Above example be only to illustrate the present invention implementer's case and it is unrestricted, although with reference to preferred embodiment pair The present invention is described in detail, still, all within the spirits and principles of the present invention, any modification for being made, equivalent replacement, Improve etc., it should all be included in the protection scope of the present invention.

Claims (10)

1. a kind of Chinese medicine composition of strengthen immunity, which is characterized in that by weight, the bulk pharmaceutical chemicals of the Chinese medicine composition Composition includes：0.2-0.4 parts of ginseng, 1-2 parts of Chinese torreyanut, 2-4 parts of almond, 4-8 parts of wild jujube, 4-8 parts of mulberries, 0.2-0.4 parts of pallas pit viper, 1-4 parts of Chinese yam, 0.5-2 parts of arillus longan, 2-8 parts of dateplum persimmon, 0.4-2.4 parts of bitter orange flower, 2-8 parts of hawthorn, 1-4 parts of matrimony vine, Longstamen Onion Bulb 1-4 Part, 0.4-2.4 parts of dark plum, 2-8 parts of jujube, 0.4-4 parts of hoveniae semoveniae semen, 0.2-1.2 parts of fennel seeds, 0.4-4 parts of Chinese cassia tree and donkey-hide gelatin 1-5 Part.
2. application of the Chinese medicine composition described in claim 1 in the product for preparing strengthen immunity.
3. a kind of herbal paste of strengthen immunity, which is characterized in that the herbal paste of the strengthen immunity includes described in claim 1 Chinese medicine composition, collagen peptide, brown sugar and honey；The Chinese medicine composition, collagen peptide, brown sugar and honey mass ratio It is 1：(0.1-2)：(0.1-0.5)：(0.1-0.6).
4. the herbal paste of strengthen immunity according to claim 3, which is characterized in that the herbal paste of the strengthen immunity is also wrapped Include preservative, the mass ratio of the preservative and Chinese medicine composition is (0.0004-0.0008)：1.
5. the herbal paste of strengthen immunity according to claim 3, which is characterized in that the herbal paste of the strengthen immunity is also wrapped Include sweetener, the mass ratio of the sweetener and Chinese medicine composition is (0.0002-0.0012)：1.
6. the herbal paste of strengthen immunity according to claim 3, which is characterized in that the collagen peptide is ox bone collagen Protein peptides, cow leather collagen peptide, fish bone collagen protein peptides, collagen peptide, collagen peptide, pig bone collagen egg At least one of white peptide, pigskin collagen peptides.
7. the preparation method of the herbal paste of strengthen immunity described in a kind of claim 3, which is characterized in that include the following steps：
(1) Chinese medicine composition as described in claim 1 bulk pharmaceutical chemicals composition weigh each bulk pharmaceutical chemicals, will in bulk pharmaceutical chemicals except donkey-hide gelatin with Outer other compositions mixing, obtains mixture, water is added in into mixture, fully impregnate, then extract, filter, concentration, Obtain just cream；
(2) it is heated after mixing donkey-hide gelatin and suitable quantity of water, until donkey-hide gelatin is completely dissolved, obtains donkey-hide gelatin liquid；
(3) donkey-hide gelatin liquid and first cream are mixed, then suitable quantity of water is added to be uniformly mixed, be then concentrated into thick paste to get Chinese traditional medicine composition Object；
(4) it is 1 in mass ratio by Chinese medicine composition, collagen peptide, brown sugar and honey under the conditions of 90-110 DEG C：(0.1- 2)：(0.1-0.5)：(0.1-0.6) is uniformly mixed, then through filling, sterilization treatment up to the herbal paste of strengthen immunity.
8. preparation method according to claim 7, which is characterized in that the mass ratio of mixture and water is 1 in step (1)： (8-12)。
9. preparation method according to claim 7, which is characterized in that the temperature extracted described in step (1) is 100 DEG C.
10. preparation method according to claim 7, which is characterized in that the number extracted described in step (1) is 2-3 times, The time extracted every time is 40-180min.
CN201810145234.3A 2018-02-12 2018-02-12 A kind of Chinese medicine composition of strengthen immunity Pending CN108245666A (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN201810145234.3A CN108245666A (en) 2018-02-12 2018-02-12 A kind of Chinese medicine composition of strengthen immunity

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN201810145234.3A CN108245666A (en) 2018-02-12 2018-02-12 A kind of Chinese medicine composition of strengthen immunity

Publications (1)

Publication Number Publication Date
CN108245666A true CN108245666A (en) 2018-07-06

Family

ID=62744354

Family Applications (1)

Application Number Title Priority Date Filing Date
CN201810145234.3A Pending CN108245666A (en) 2018-02-12 2018-02-12 A kind of Chinese medicine composition of strengthen immunity

Country Status (1)

Country Link
CN (1) CN108245666A (en)

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105664102A (en) * 2016-02-16 2016-06-15 北京御心堂生物科技有限公司 Traditional Chinese medicine composition for improving immunity
CN106387158A (en) * 2016-08-19 2017-02-15 江西汇仁药业股份有限公司 Health-care tea and preparation method thereof
CN106692589A (en) * 2017-01-19 2017-05-24 奉化市同发梅花鹿养殖专业合作社 Deer foetus semifluid extract and preparation process thereof
CN107296949A (en) * 2017-07-13 2017-10-27 山东仁迪生物工程集团有限公司 Integration of drinking and medicinal herbs compound formulation and its preparation method and application

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105664102A (en) * 2016-02-16 2016-06-15 北京御心堂生物科技有限公司 Traditional Chinese medicine composition for improving immunity
CN106387158A (en) * 2016-08-19 2017-02-15 江西汇仁药业股份有限公司 Health-care tea and preparation method thereof
CN106692589A (en) * 2017-01-19 2017-05-24 奉化市同发梅花鹿养殖专业合作社 Deer foetus semifluid extract and preparation process thereof
CN107296949A (en) * 2017-07-13 2017-10-27 山东仁迪生物工程集团有限公司 Integration of drinking and medicinal herbs compound formulation and its preparation method and application

Non-Patent Citations (5)

* Cited by examiner, † Cited by third party
Title
国家药典委员会: "《中华人民共和国药典》", 31 March 2016 *
庞国明等: "《膏方临床应用指南》", 31 January 2012, 中国医药科技出版社 *
施仁潮: "《补气药》", 31 December 2016, 金盾出版社 *
王亨达等: "《中医食方食品概论》", 30 June 2016, 上海科学技术文献出版社 *
王凤岐等: "《大众养生调理膏方》", 31 January 2017, 科学技术文献出版社 *

Similar Documents

Publication Publication Date Title
US5807554A (en) Herbal formulations with nacre
CN107126485A (en) It is a kind of to aid in improving Chinese medicine composition of sleep and its preparation method and application
CN107213451A (en) Improve probiotics fermention Chinese medicine preparation of microcirculation in human body obstacle and preparation method thereof
CN102920806B (en) Nerve-soothing blood-pressure-reducing traditional Chinese medicine tea
CN108066712A (en) A kind of benefiting qi and nourishing blood Chinese medicine composition
CN103877486B (en) For medicine and its preparation method of quantity of leucocyte after short lifting chemotherapy
CN108813501A (en) With the relieving cough and reducing sputum health honey paste relievingd asthma and adjust function of human body of clearing heat and moistening lung
CN107596197A (en) A kind of strongly fragrant tea of tonifying Qi solution and preparation method thereof
CN103919899A (en) Pharmaceutical composition, preparation method, preparation and application thereof
CN102008083B (en) Health food for alleviating physical fatigue and removing chloasma
RU2174003C1 (en) Pharmaceutical curative composition, method of curative and curative- prophylactic use of thereof
CN108478714A (en) A kind of paediatrics self-closing disease rehabilitation auxiliary Chinese medicine composition
CN108633997A (en) A kind of healthcare goat milk powder and preparation method thereof with anti-fatigue effect
CN104524174A (en) Traditional Chinese medicine composition for treating rheumatic arthralgia and preparation method thereof
CN108245666A (en) A kind of Chinese medicine composition of strengthen immunity
CN106822660A (en) A kind of Chinese medicine preparation for treating cardiovascular and cerebrovascular disease
CN106942561A (en) A kind of beverage composition for treating dental erosion and preparation method and application
CN106177651A (en) A kind of infantile malnutrition medicine
CN102784230A (en) Pharmaceutical composition preparation for treating nutritional anemia
CN105028832A (en) Blueberry tea capable of alleviating fatigue of eyes and preparation method of blueberry tea
CN109718304A (en) Improve the Chinese medicine composition of the microcirculation of human body cardio and vascular function and pre- preventing thrombosis
CN108813500A (en) With tonifying middle-Jiao and Qi, nourishing blood and tranquilization and the health honey paste for adjusting function of human body
CN109718305A (en) Improve energy and blood of human body function and improves the Chinese medicine composition that resist oxygen lack delays senescence
CN103251816A (en) Preparation for enhancing immunity and preparation method thereof
CN108524850A (en) A kind of liquor preparation for enhancing immune prevention cardiovascular and cerebrovascular disease

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
RJ01 Rejection of invention patent application after publication
RJ01 Rejection of invention patent application after publication

Application publication date: 20180706