CN109718305A - Improve energy and blood of human body function and improves the Chinese medicine composition that resist oxygen lack delays senescence - Google Patents

Improve energy and blood of human body function and improves the Chinese medicine composition that resist oxygen lack delays senescence Download PDF

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CN109718305A
CN109718305A CN201910214913.6A CN201910214913A CN109718305A CN 109718305 A CN109718305 A CN 109718305A CN 201910214913 A CN201910214913 A CN 201910214913A CN 109718305 A CN109718305 A CN 109718305A
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blood
weight
chinese medicine
radix
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傅金荣
付金洪
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Tianyuan Jiangxi Pharmaceutical Co Ltd
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Tianyuan Jiangxi Pharmaceutical Co Ltd
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Abstract

The present invention relates to improve energy and blood of human body function to improve the Chinese medicine composition that resist oxygen lack delays senescence.The Chinese medicine composition is made of Radix Astragali, Radix Angelicae Sinensis, Rehmannia glutinosa, Radix Codonopsis, donkey-hide gelatin, ferrous gluconate and optional pharmaceutic adjuvant.Specifically it is made of 1200 parts by weight of Radix Astragali, 400~600 parts by weight of Radix Angelicae Sinensis, 300~500 parts by weight of Rehmannia glutinosa, 300~500 parts by weight of Radix Codonopsis, 100~300 parts by weight of donkey-hide gelatin, 20~40 parts by weight of ferrous gluconate and optional pharmaceutic adjuvant.The preparation method and the Chinese medicine composition for further relating to the Chinese medicine composition are being prepared for improving energy and blood of human body function and improving the purposes in the product that resist oxygen lack delays senescence.Present composition presentation can for example improve energy and blood of human body function and improve resist oxygen lack anti-aging excellent effect.

Description

Improve energy and blood of human body function and improves the Chinese medicine composition that resist oxygen lack delays senescence
Technical field
The invention belongs to medical and health product scopes, are related to one kind and prolong for improving energy and blood of human body function and improving resist oxygen lack The Chinese medicine composition of slow aging, further relates to the preparation process and its detection method of the Chinese medicine composition, more particularly to one kind Hai Ruikang board astragalus, angelica donkey-hide gelatin mouth can be for example referred to as with what raising resist oxygen lack delayed senescence for improving energy and blood of human body function Take the Chinese medicine composition and their preparation method and its detection method of liquid.
Background technique
Alimentary anemia is divided into small cell anemia and two kinds of macrocytic anemia.The former is also hypoferric anemia, multiple In baby, children；The latter is called megaloblastic anemia, and the cause of disease is that the factor of erythrocyte maturation is made to lack and fall ill.
Alimentary anemia is belonged to scope caused by " deficiency of blood ", " consumptive disease " by traditional Chinese medicine, it is believed that blood sources are in spleen, at all in kidney And it is dirty to be related to the heart, liver two, if weakness of the spleen and the stomach, cannot cure that digesting and absorbing the essence of foodstuff is precise and tiny, and source of generating QI and blood is insufficient, generate anaemia.And it mends Blood agent is with "Nei Jing" " treating deficiency with tonification, damage then benefit " scheduling theory be foundation prescription compatibility a kind of prescription.Therefore, Fang Zhongchang matches 5 Qi-tonifying drugs, to play the function of qi-supplementing, blood-engendering.It is so-called just as " Wen Bing Tiao Bian controls blood opinion ": " deficiency of blood person, mends its gas and blood is spontaneous ".Kidney Store essential substances, the raw marrow of essence, marrow green blood, therefore have saying for " source of blood being kidney ".Your red oral solution of Hai Ruikang board blood be with Radix Astragali, when Return, Rehmannia glutinosa, Radix Codonopsis, donkey-hide gelatin, ferrous gluconate be raw material made of health food, proved through function test, have improve The healthcare function of alimentary anemia.
Anaemia is a kind of disease relatively common in China resident, and a kind of global disease, pair of anaemia invasion As also the most extensively, including children and adolescents, there are also adult men and women, especially pregnant woman and wet nurse and children.Alimentary anemia Main six big performances: 1. onset is slow, and generally discovery skin and mucosa is gradually pale before this, especially most bright with lip and nail matrix It is aobvious；2. fatigue and weak, does not like activity, often there is dysphoria or dispirited；3. appetite stimulator often has vomiting or diarrhea, has Children will appear allotriophagy；4. doctor can have found the hepatosplenomegaly of children when checking, increased heart rate, laboratory examination is with blood red egg Based on white reduction；5. patient's appearance is mostly puffiness, hair sparse jaundice, ochriasis, fatigue and weak, loss of appetite；6. intelligence Development with movement all relatively falls behind, or even gradually regresses.
Alimentary anemia is one of highest nutritional deficiency disease of whole world disease incidence, right according to the World Health Organization (WTO) Just suffer from the investigation of alimentary anemia in world population 5,000,000,000, there are about 10~30% crowds to have different degrees of iron deficiency i.e. in the whole world There are 1,000,000,000 people.Disease incidence in China is also very high, " Chinese residents nutrition in 2004 and health status " disclosure, China residence The people suffer from anemia rate average out to 13.6% because of iron deficiency；Infant within two years old, 60 years old or more old man, women of child-bearing age's anaemia illness Rate is respectively 21.7%, 18.5%, 20.6%；Another group is since melt quality lacks, and Chinese hypoferric anemia incidence reaches 15~20%, women and children's anemia rate is up to 20%, and iron deficiency is classified as the big nutrient in the world four by the World Health Organization (WTO) and lacks One of disease.Therefore, it enriches blood the product huge market demand.
When demand and supply of the body to iron is unbalance, lead to store iron loss in vivo to the greatest extent (ID), followed by Erythrocyte Iron lacks (IDE), finally cause hypoferric anemia (IDA).IDA is the terminal stage of asiderosis (including ID, IDE and IDA), is shown as Microcytic hypochromic anemia caused by iron deficiency and other exceptions.IDA is the most common anaemia.Its disease incidence is in development China Family, economically less developed region and infant, the women of child-bearing age obviously increase.Shanghai population investigation display: the year of asiderosis Disease incidence is in 6 months~2 years old infant 75.0%~82.5%, 3 months pregnant or more women 66.7%, the women of child-bearing age 43.3%, 10 years old~17 years old teenager 13.2%；The above crowd IDA illness rate is respectively 33.8%~45.7%, 19.3%, 11.4%, 9.8%.It is main related to following factors to suffer from asiderosis: the addition of infant's diatery supplement is insufficient, teenager's partial eclipse, women Excessive menstruation/multiple pregnancies/lactation and certain pathological factors (the big portion's excision of such as stomach, chronic blood loss, chronic diarrhea, atrophic Gastritis and hookworm infection etc.) etc..The multiple group of hypoferric anemia is infant, Women of childbearing age.The common disease of hypoferric anemia Shape is out of strength, easy tired, dizziness headache, dim eyesight, tinnitus, palpitaition etc..
The common disease factor of hypoferric anemia is caused by chronic wasting disease, malnutrition, hookworm infection etc..Under in addition, Column reason is also the common disease factor of hypoferric anemia: 1. need iron increase and iron insufficiency of intake: be more common in infant, teenager, Gestation and breast feeding women.Infant needs iron more, if not supplementing the higher diatery supplement of the iron-content such as eggs, meat, easily causes Iron deficiency.The easy iron deficiency of teenager's partial eclipse.Feminine menstrual increases, gestation or lactation, needs iron to increase, if not supplementing high-speed rail food, easily Cause IDA.2. iron malabsorption: being common in Partial gestrectomy, gastric acid secretion is insufficient and food rapidly enters jejunum, bypasses The major absorption site (duodenum) of iron absorbs iron and reduces.In addition, functional disturbances of gastrointestinal tract caused by many reasons, such as Because of iron malabsorption IDA can occur for long-term unknown cause diarrhea, chronic enteritis, clone's disease etc..3. iron is lost excessive: chronic Long-term iron is lost and cannot be corrected, and IDA is caused.Such as: chronic gastrointestinal blood loss (including hemorrhoid, gastroduodenal ulcer, food Pipe ceasma hernia, gastrointestinal polyps, gastroenteric tumor, parasitic infection, oesophagus/Therapy for Gastric Variceal etc.), excessive menstruation (Pulmonary hemosiderosis is calm for (in utero placing the gynecological diseases such as intrauterine device, fibroid and menstrual disorder), hemoptysis and alveolar bleeding Disease, Goodpasture syndrome, pulmonary tuberculosis, bronchiectasis, lung cancer etc.), hemoglobinuria (the blood red egg of paroxysmal nocturnal Albiduria, cold anitibody type autoimmune hemolytic anemia, artificial cardiac valve prosthesis, march hemoglobinuria etc.) and other (heredity bleedings Property telangiectasia, is repeatedly donated blood at the haemodialysis of chronic renal failure row).It enriches blood product situation from existing market From the point of view of, product main component of enriching blood is two classes: one kind is ferrous lactate, PORPHYRIN IRON, ferrous sulfate, ferrous citrate, glucose The chemical syntheses ingredients such as sour ferrous iron, Vc, it is clinically relatively more efficient at present that anaemia is treated by taking ferrous gluconate Method；It is another kind of be for the animals and plants such as donkey-hide gelatin, honey, Gallus domesticlus brisson, fructus lycii, soybean lecithin, ginseng, Radix Angelicae Sinensis, Radix Astragali and Chinese herbal medicine at Point.However on the market there is not yet chemical synthesis ingredient and animals and plants and medicinal herb components combination are realized the product enriched blood.
Additionally, it is well known that, by take combination enrich blood product can be also used for human body improve resist oxygen lack delay senescence.
Therefore, new enrich blood product and method of enriching blood still are expected to have in this field, especially for example by by chemical synthesis Method that the product enriched blood and realization are enriched blood is realized in ingredient and animals and plants and medicinal herb components combination；In addition, based on this By way of taking and enriching blood product, resist oxygen lack anti-aging is improved to improve energy and blood of human body function, is also art technology What personnel urgently expected.
Summary of the invention
It enriches blood and product and enriches blood method the purpose of the present invention is to provide one kind, to improve energy and blood of human body function and raising Resist oxygen lack delays senescence.It has been had now surprisingly been found that, it is provided by the invention to can be used for improving energy and blood of human body function and raising The Chinese medicine composition that can be for example referred to as Hai Ruikang board astragalus, angelica ass glue oral liquid that resist oxygen lack delays senescence presents excellent Technical effect.It is accomplished the present invention is based on this discovery.
In a first aspect, the present invention provides a kind of Chinese medicine composition, by Radix Astragali, Radix Angelicae Sinensis, Rehmannia glutinosa, Radix Codonopsis, donkey-hide gelatin, Portugal Grape saccharic acid is ferrous and optional pharmaceutic adjuvant is made.
Chinese medicine composition according to a first aspect of the present invention, by 1200 parts by weight of Radix Astragali, 400~600 parts by weight of Radix Angelicae Sinensis, 300~500 parts by weight of Rehmannia glutinosa, 300~500 parts by weight of Radix Codonopsis, 100~300 parts by weight of donkey-hide gelatin, ferrous gluconate 20~40 Parts by weight and optional pharmaceutic adjuvant are made.
Chinese medicine composition according to a first aspect of the present invention, by 1200 parts by weight of Radix Astragali, 450~550 parts by weight of Radix Angelicae Sinensis, 350~450 parts by weight of Rehmannia glutinosa, 350~450 parts by weight of Radix Codonopsis, 150~250 parts by weight of donkey-hide gelatin, ferrous gluconate 25~35 Parts by weight and optional pharmaceutic adjuvant are made.
Chinese medicine composition according to a first aspect of the present invention, by 1200 parts by weight of Radix Astragali, 500 parts by weight of Radix Angelicae Sinensis, radix rehmanniae preparata Yellow 400 parts by weight, 400 parts by weight of Radix Codonopsis, 200 parts by weight of donkey-hide gelatin, 32 parts by weight of ferrous gluconate and optionally medicinal auxiliary Material is made.
Chinese medicine composition according to a first aspect of the present invention is the liquid preparation of drink form.
Chinese medicine composition according to a first aspect of the present invention is the liquid preparation of drink form, prepares every 100ml The Milkvetch Root amount used is 8~16g.
Chinese medicine composition according to a first aspect of the present invention is the liquid preparation of drink form, prepares every 100ml The Milkvetch Root amount used is 10~14g.
Chinese medicine composition according to a first aspect of the present invention is the liquid preparation of drink form, prepares every 100ml The Milkvetch Root amount used is 12g.
Chinese medicine composition according to a first aspect of the present invention, wherein the pharmaceutic adjuvant includes flavoring agent.Implement at one In scheme, the flavoring agent is sweetener, such as aspartame, acesulfame potassium, saccharin sodium, sucrose (such as white granulated sugar) etc..This The dosage of a little sweeteners can determine readily according to its specifically used kind and the experience of those skilled in the art, for example, Ah The amount for taking charge of Batan, acesulfame potassium, saccharin sodium etc. is usually 0.05%~1%, and especially such as 0.1%, such as sucrose (such as white sand Sugar) the 5~25% of the traditional chinese medicine composition of the invention weight, such as 10~20%, such as 10%, 12%, 15%, 20% can be accounted for. The expectation sugariness of product can also be especially obtained according to the different dosages using the factors such as the preference of crowd decision sweetener, The selection of this sweetener dosage is well known to those skilled in the art, and their type and dosage will not influence product Physicochemical property.
Chinese medicine composition according to a first aspect of the present invention is the liquid preparation of drink form, by including as follows The method of step is made:
(1) Radix Astragali, Radix Angelicae Sinensis, Rehmannia glutinosa, Radix Codonopsis are taken, adds purified water to decoct secondary (for example, adding 5~8 times such as 6 for the first time The purified water of amount decocts 1~3h such as 2h again, and filtering obtains filtrate；Second of filter residue adds the purifying decocting of 5~8 times of such as 6 times amounts 1~3h such as 2h is boiled, filters, obtains filtrate), merge filtrate twice；
(2) by combined filtrate, medical fluid and 0.8~1.2:1 of medicinal material weight ratio such as 1:1 are concentrated under reduced pressure into；Ethyl alcohol is added (such as concentration be more than or equal to 90% or the ethyl alcohol more than or equal to 95%) reach alcohol content (such as to alcohol content up to 55~65% 60%) alcohol precipitation 20~30 hours, are stood, takes supernatant, filters, obtains filtrate；
(3) ethyl alcohol is recovered under reduced pressure at a temperature of 60~80 DEG C in filtrate obtained by step (2), until without alcohol taste, no alcohol liquid decompression Being concentrated into relative density is 1.05~1.08 (40 DEG C of temperature of measurement), obtains Chinese medicine extract, spare；
(4) donkey-hide gelatin is pounded fine grained chippings, adds the purified water heating of such as 10 times amounts of 8~12 times of amounts to make it completely dissolved, mistake Filter, it is spare；
(5) ferrous gluconate and optional flavoring agent (such as sucrose) are merged, adds the pure of such as 3 times amounts of 2~4 times of amounts Change water to dissolve by heating, it is spare；
(6) above step (3), (4), (5) each medical fluid are merged, is uniformly mixed, adds purified water constant volume, stir evenly, mistake Filter, packing, sealing, pressure sterilizing (such as 105 DEG C of sterilizing 45min) to get.
Chinese medicine composition according to a first aspect of the present invention, wherein the pharmaceutic adjuvant further includes sodium citrate and sorb Alcohol.In one embodiment, the weight ratio of medicinal material Radix Astragali and sodium citrate is 12:0.1.In one embodiment, medicinal material The weight ratio of Radix Astragali and sorbierite is 12:0.5.In one embodiment, sodium citrate and sorbierite are in step (2) gained It is added in filtrate.
Chinese medicine composition according to a first aspect of the present invention, wherein the pharmaceutic adjuvant further includes sodium tartrate and sweet ammonia Acid.In one embodiment, the weight ratio of medicinal material Radix Astragali and sodium tartrate is 12:0.25.In one embodiment, medicinal material The weight ratio of Radix Astragali and glycine is 12:0.75.In one embodiment, sodium tartrate and glycine are in step (2) institute Add in filtrate.
Further, second aspect of the present invention, which provides, prepares any implementation of Chinese medicine composition such as first aspect present invention The method of Chinese medicine composition described in scheme, the Chinese medicine composition is by Radix Astragali, Radix Angelicae Sinensis, Rehmannia glutinosa, Radix Codonopsis, donkey-hide gelatin, gluconic acid Ferrous and optional pharmaceutic adjuvant is made；This method comprises the following steps:
(1) Radix Astragali, Radix Angelicae Sinensis, Rehmannia glutinosa, Radix Codonopsis are taken, adds purified water to decoct secondary (for example, adding 5~8 times such as 6 for the first time The purified water of amount decocts 1~3h such as 2h again, and filtering obtains filtrate；Second of filter residue adds the purifying decocting of 5~8 times of such as 6 times amounts 1~3h such as 2h is boiled, filters, obtains filtrate), merge filtrate twice；
(2) by combined filtrate, medical fluid and 0.8~1.2:1 of medicinal material weight ratio such as 1:1 are concentrated under reduced pressure into；Ethyl alcohol is added (such as concentration be more than or equal to 90% or the ethyl alcohol more than or equal to 95%) reach alcohol content (such as to alcohol content up to 55~65% 60%) alcohol precipitation 20~30 hours, are stood, takes supernatant, filters, obtains filtrate；
(3) ethyl alcohol is recovered under reduced pressure at a temperature of 60~80 DEG C in filtrate obtained by step (2), until without alcohol taste, no alcohol liquid decompression Being concentrated into relative density is 1.05~1.08 (40 DEG C of temperature of measurement), obtains Chinese medicine extract, spare；
(4) donkey-hide gelatin is pounded fine grained chippings, adds the purified water heating of such as 10 times amounts of 8~12 times of amounts to make it completely dissolved, mistake Filter, it is spare；
(5) ferrous gluconate and optional flavoring agent (such as sucrose) are merged, adds the pure of such as 3 times amounts of 2~4 times of amounts Change water to dissolve by heating, it is spare；
(6) above step (3), (4), (5) each medical fluid are merged, is uniformly mixed, adds purified water constant volume, stir evenly, mistake Filter, packing, sealing, pressure sterilizing (such as 105 DEG C of sterilizing 45min) to get.
Method according to a second aspect of the present invention, the Chinese medicine composition is by 1200 parts by weight of Radix Astragali, Radix Angelicae Sinensis 400~600 Parts by weight, 300~500 parts by weight of Rehmannia glutinosa, 300~500 parts by weight of Radix Codonopsis, 100~300 parts by weight of donkey-hide gelatin, gluconic acid are sub- 20~40 parts by weight of iron and optional pharmaceutic adjuvant are made.
Method according to a second aspect of the present invention, the Chinese medicine composition is by 1200 parts by weight of Radix Astragali, Radix Angelicae Sinensis 450~550 Parts by weight, 350~450 parts by weight of Rehmannia glutinosa, 350~450 parts by weight of Radix Codonopsis, 150~250 parts by weight of donkey-hide gelatin, gluconic acid are sub- 25~35 parts by weight of iron and optional pharmaceutic adjuvant are made.
Method according to a second aspect of the present invention, the Chinese medicine composition is by 1200 parts by weight of Radix Astragali, 500 weight of Radix Angelicae Sinensis Part, 400 parts by weight of Rehmannia glutinosa, 400 parts by weight of Radix Codonopsis, 200 parts by weight of donkey-hide gelatin, 32 parts by weight of ferrous gluconate and optional Pharmaceutic adjuvant is made.
Method according to a second aspect of the present invention, the Chinese medicine composition are the liquid preparation of drink form.
Method according to a second aspect of the present invention, the Chinese medicine composition are the liquid preparation of drink form, preparation The Milkvetch Root amount that every 100ml is used is 8~16g.
Method according to a second aspect of the present invention, the Chinese medicine composition are the liquid preparation of drink form, preparation The Milkvetch Root amount that every 100ml is used is 10~14g.
Method according to a second aspect of the present invention, the Chinese medicine composition are the liquid preparation of drink form, preparation The Milkvetch Root amount that every 100ml is used is 12g.
Method according to a second aspect of the present invention, the pharmaceutic adjuvant include flavoring agent.In one embodiment, described Flavoring agent be sweetener, such as aspartame, acesulfame potassium, saccharin sodium, sucrose (such as white granulated sugar) etc..The use of these sweeteners Amount can be determined readily according to its specifically used kind and the experience of those skilled in the art, such as aspartame, An Sai The amount of honey, saccharin sodium etc. is usually 0.05%~1%, and especially such as 0.1%, such as sucrose (such as white granulated sugar) can account for this The 5~25% of invention Chinese medicine composition weight, such as 10~20%, such as 10%, 12%, 15%, 20%.It especially can be with The dosage of sweetener is determined to obtain the expectation sugariness of product using factors such as the preferences of crowd according to different, and this sweetener is used The selection of amount is well known to those skilled in the art, and their type and dosage will not influence the physicochemical property of product.
Method according to a second aspect of the present invention, the pharmaceutic adjuvant further include sodium citrate and sorbierite.In a reality It applies in scheme, the weight ratio of medicinal material Radix Astragali and sodium citrate is 12:0.1.In one embodiment, medicinal material Radix Astragali and sorbierite Weight ratio be 12:0.5.In one embodiment, sodium citrate and sorbierite are added in the filtrate obtained by step (2) 's.
According to method of the first aspect of the present invention, the pharmaceutic adjuvant further includes sodium tartrate and glycine.In a reality It applies in scheme, the weight ratio of medicinal material Radix Astragali and sodium tartrate is 12:0.25.In one embodiment, medicinal material Radix Astragali and sweet ammonia The weight ratio of acid is 12:0.75.In one embodiment, sodium tartrate and glycine are added in the filtrate obtained by step (2) Add.
Further, third aspect present invention provides Chinese medicine composition described in first aspect present invention any embodiment Or Chinese medicine composition made from second aspect of the present invention any embodiment the method is being prepared for improving energy and blood of human body The purposes in product that function and raising resist oxygen lack delay senescence.
Further, fourth aspect present invention is provided using rp-hplc determination first aspect present invention Chinese medicine group made from Chinese medicine composition described in any embodiment or second aspect of the present invention any embodiment the method The method for closing the content of calycosin glucoside in object, the reversed-phased high performace liquid chromatographic use Kromasil C18 column (4.6mm × 200mm, 5 μm), mobile phase are acetonitrile-water (28:72), flow velocity 1.0mL/min, Detection wavelength 267nm.
Either side according to the present invention, wherein the Chinese medicine composition can be used as health care product, health food, health beverage Material or medical product.
Any embodiment of either side according to the present invention, wherein the Chinese medicine composition has such as any reality of the present invention Apply formula described in any one of example.
Any embodiment of either side according to the present invention, wherein institute's Chinese medicine composition has such as any implementation of the present invention Formula and preparation method described in any one of example.
In the above-mentioned preparation method of the invention the step of, although the specific steps of its description are in certain details or language In description with the preparation example of following detailed description part described in step different from, however, those skilled in the art The detailed disclosure of member's full text according to the present invention can summarize approach described above step completely.
Any embodiment in either present invention face can be combined with other embodiments, as long as they are not It will appear contradiction.In addition, any technical characteristic can be adapted for other realities in any embodiment of either side of the present invention The technical characteristic in scheme is applied, as long as they are not in contradiction.The invention will be further described below.
All documents recited in the present invention, their full content are incorporated herein by reference, and if these are literary When offering expressed meaning and the inconsistent present invention, it is subject to statement of the invention.In addition, the various terms that use of the present invention and Phrase has that well known to a person skilled in the art general senses, nonetheless, the present invention remain desirable at this to these terms and Phrase is described in more detail and explains, the term and phrase referred to is if any inconsistent with common art-recognized meanings, with institute's table of the present invention Subject to the meaning stated.
Chinese medicine composition of the invention is made of Radix Astragali, Radix Angelicae Sinensis, Rehmannia glutinosa, Radix Codonopsis, donkey-hide gelatin, ferrous gluconate.
Radix Astragali (Astragalus membranaceus (Fisch.) Bunge.), also known as continuous stilbene.Main root is plump, wooden, often Branch, canescence.Stem is upright, and top multi-branched has thin rib, by white pubescence.Perennial herb is 50-100 centimetres high.It originates in The ground such as the Inner Mongol, Shanxi, Gansu, Heilungkiang are state three level protecting plant.Medicinal existing more than 2000 years so far of Radix Astragali are gone through History has enhancing body's immunity, liver protection, diuresis, anti-aging, resisting stress, decompression and wide antibacterial action.But table is real Heresy is contained, retention of dampness due to stagnation of QI, and dyspepsia is stagnated, ulcer initial stage or heat toxin such as still contains at real examples and the hyperactivity of yang due to yin deficiency person after bursting, and must prohibit clothes. Due to long-term a large amount of excavations, the quantity of wild Radix Astragali was sharply reduced in recent years, there is the danger for tending to die out.The plant is determined thus Object is vulnerable species, state three level protecting plant.
Radix Astragali is sweet, taste temperature, return lung, spleen, liver and kidney channel.
The medical value of Radix Astragali includes: 1, exterior deficiency spontaneous perspiration: being chiefly used in the weak caused spontaneous perspiration of physically weak table.Such as exterior Qi instability, and Sweating controls it with Rhizoma Atractylodis Macrocephalae, radix saposhnikoviae with Radix Astragali, and long term usage must imitate.Side such as Yupingfeng San；It can also be with Fructus Tritici Levis, radix ephedrae etc..2, the deficiency of Yin Night sweat: it can be used together with drugs for nourishing yin such as Radix Rehmanniae, Radix Ophiopogonis.3, acute nephritis edema: for void oedema caused by YANG QI deficiency, and often It closes and uses with tetrandra root, Poria cocos, Rhizoma Atractylodis Macrocephalae etc., side's such as Tetrandra and Astragalus Decoction.4, oedema due to chronic nephritis, spleen kidney deficiency: often with Radix Codonopsis, Rhizoma Atractylodis Macrocephalae, Poria cocos is the same as use.5, yang-energy is weak: invaginating for sore not ulceration long, has and promote ulceration and limitation effect.Ulcer not penetrator long, Often with pangolin, spina gleditsiae, Radix Angelicae Sinensis, Rhizoma Chuanxiong with use.6, it sore ulceration: does not close up long, there is the effect of promoting granulation and wound healing, Chang Peiyin Flower, spina gleditsiae, Chinese violet etc..Fester cleaning, is equal with Radix Codonopsis, cortex cinnamomi and uses.7, syndrome of deficiency of lung qi: cough and asthma with the passing of time, shortness of breath and tired spirit, phlegm harmony in Lung is powerlessly brought up.Chang Peiwu aster, coltsfoot etc., warm lung Dingchuan are good for the product of lung qi.Spleen gives birth to phlegm, and lung stores up phlegm, so being good for lunar to dispel Phlegm, Radix Astragali tonifying Qi is so the You Shanzhi deficiency of vital energy.8, the deficiency of vital energy is weak: fatigue and weakness or the sinking of qi of middle-jiao, rectal prolapse, uterine prolapse.Tonifying Qi is strong Spleen, often with the compatibilities such as Radix Codonopsis, Rhizoma Atractylodis Macrocephalae；It lifts for benefiting qi and raising yang sunken, is often shared with Radix Codonopsis, cimicifugae foetidae, radix bupleuri, radix glycyrrhizae preparata etc..
Clinically it is applied to: 1, high blood pressure；2, ischemic heart disease；3, acute glomerulonephritis；4, H. pylori Bacterium positive gastric ulcer；5, psoriasis；6, diabetes；7, rhinitis chronic；8, osteoporosis.
Radix Astragali is the common people's often edible pure natural product, folklore blurting out for " often drinking astragali seu Hedysari Decoction, disease-prevention health health " Slip, mean through common Radix Astragali with Qiongzhen Ganoderma Lucidum decoction or it is soaked on behalf of the tea, there is good disease-prevention health effect.Radix Astragali and Ginseng belongs to tonifying Qi good medicine, and ginseng, which biases toward, to reinforce vital energy, recuperating depleted yang, and it is preferable to be usually used in acute diseases, the effects such as collapse, shock. And Radix Astragali is then based on qi-restoratives, be usually used in body decline with the passing of time, speech is low, thin and weak pulse person.Some people hold once chance Changes in weather Easy catching a cold, Chinese medicine are known as " table is not solid ", can consolidate table with Radix Astragali, informal dress Radix Astragali can be to avoid regular flu.
Modern medicine study shows that Radix Astragali has enhancing body's immunity, liver protection, diuresis, anti-aging, resisting stress, decompression With wide antibacterial action.Experimental nephritis proteinuria can be eliminated, myocardial contractive power is enhanced, adjusts blood-sugar content.Radix Astragali is not It is only capable of coronary artery dilator, improves myocardial blood supply, improves immune function, and be capable of the process of delaying cell aging.Radix Astragali food With convenient, can decoction, soft extracts, infusing drugs in wine enters dish etc..
The effect of there is Radix Astragali tonifying Qi and tonifying Qi to promote the production of body fluid, qi-supplementing, blood-engendering, and often mutually must be used, it can mutually heighten the effect of a treatment.But Ginseng effect is stronger, is known as the first key medicine of tonifying Qi, and has QI invigorating emergency treatment of collapse, calm the nerves increasing intelligence, the function that tonifying Qi is supporing yang.Radix Codonopsis tonifying Qi Power it is more gentle, specially in the gas of help spleen and lung, and can enrich blood.The power of Radix Astragali help vigour is longer than tonifying Qi liter not as good as ginseng Sun, invigorating qi for consolidating superficies, torr sore myogenic, profit water detumescence are suitable for sinking of QI due to deficiency of the spleen and exterior deficiency spontaneous perspiration etc. to be demonstrate,proved especially.
In terms of the chemical component of Radix Astragali, mainly containing glycoside, polysaccharide, flavones, amino acid, microelement etc..
Rehmannia glutinosa, original name: glutinous rehmannia, also known as: bosom celebrating glutinous rehmannia, radix rehmanniae preparata.Latin literary fame: Rehmannia glutinosa (Gaetn.) Libosch.ex Fisch.et Mey. Scrophulariaceae, glutinous rehmannia platymiscium, it is close by the long pubescence of canescence many cells and gland Hair.Rhizome is medicinal.Chinese medicine Rehmannia glutinosa is the Preparation process product of radix rehmanniae recen, and surface is pitch-black glossy, and matter is soft and flexible, taste Sweet, slightly warm in nature has nourishing yin and supplementing blood, beneficial to spirit and marrow and other effects.The deficiency of liver-yin and kidney-yin, soreness and weakness of waist and knees, osteopyrexia and fever, night sweat is cured mainly to lose The diseases such as essence, Heat Diabetes, blood deficiency chlorosis, palpitation and severe palpitation, irregular menstruation, dizziness and tinnitus, poliosis.Radix rehmanniae recen is fumigated to black Profit is Rehmannia glutinosa, which is irregular bulk, and not of uniform size, inside and outside is pitch-dark color, and glossy, outer surface shrinkage is uneven.It is disconnected Face is moistened, the grease-like block of the visible light of central part, and viscosity is big, and matter is soft, and gas is micro-, sweet.It steams nine by nine to shine, with root tuber fertilizer Greatly, soft profit, inside and outside pitch-black glossy person are preferred.
In terms of meridian distribution of property and flavor.It is sweet in flavor；It is warm-natured.Return liver；Kidney channel.Effect: enrich blood moist；Beneficial to spirit and marrow；For the deficiency of blood It is sallow；Dizziness palpitaition；Irregular menstruation；It collapses more than；Liver-kidney Yin deficiency；Hectic fever night sweat；Spermatorrhea impotence；Infertility；Irregular menstruation；It collapses Leak down blood；Soreness and weakness of waist and knees；Hiccough and deaf；It is dim-sighted；Poliosis；It quenches one's thirst；Constipation；Kidney deficiency characterized by dyspnea.
Glutinous rehmannia has extensive pharmacological action.Syndrome effect is formed to Intravascular Thrombus about Rehmannia glutinosa and radix rehmanniae recen Drug effect relatively shows: in domestic pig gall shape thick Rehmannia glutinosa can strong inhibition liver hemorrhagic necrosis stove and pure it is bad Extremely.And the effect of Rehmannia glutinosa antithrombase is weaker.It is visited using fibrin plate method by plasminogen activation The activation to fibrinolytic system is begged for, discovery radix rehmanniae preparata has activation, and radix rehmanniae recen is without this effect.Also report thinks, ground Huang has anastalsis before and after frying charcoal, and anastalsis and does not reinforce after glutinous rehmannia charcoal processing.To radix rehmanniae recen, Rehmannia glutinosa, fresh rehmannia charcoal, ripe The decocting liquid haemostatic effect of ground charcoal is analyzed, and as a result there was no significant difference.Experiment discovery: bosom celebrating Rehmannia glutinosa water decoction gavages, The weight loss of hyperthyroidism type deficiency of Yin rat can be enable to alleviate, 24 hours amounts of drinking water and urine volume significantly reduce, blood plasma T3, T4 concentration Level is significantly improved (i.e. T3 is reduced, T4 is increased) and AD (aldosterone in blood plasma) is horizontal significantly raised.It is relatively strong to prove that it truly has Nourishing yin effect.And be initially believed that, the effect of radix rehmanniae preparata enriching yin and nourishing kidney is related with internal AD level is improved.
Rehmannia glutinosa water decoction can obviously increase animal blood serum Glutathione Peroxidase (GSH-Px) to mouse gavaging Activity；Reduce the content of lipid peroxide in serum.Can make the activity of superoxide dismutase in blood (SOD) has to a certain degree Raising, but without statistical meaning.On catalase activity in blood without influence.Rehmannia glutinosa is to rat portions internal organs protein Metabolism has certain effect.Rehmannia glutinosa is oral to have the inhibition mitotic effect of epithelial cell.Experiment shows: based on Rehmannia glutinosa The Rehmanniae Decoction of Six Ingredients of medicine is to normal mouse in addition to it can put on weight, extend swimming time, outside enhancing physical strength, moreover it is possible to reduce N- nitrous The induction rate of mice model of forestomach squamous carcinoma caused by base sarcosine ethyl makes the animal spleen lymph nodule hair tonic for receiving chemical carcinogen Center active proliferation can enhance the phagocytic activity of Mononuclear phagocyte system at the initial stage of inoculation transplanted tumor, improve tumor animal The ratio of albumin and globulin in blood, can seemingly extend the time-to-live of tumor animal.(1) Rehmannia glutinosa delays the work of mice age With: the daily stomach-filling 0.3ml of 20% decocting liquid of Rehmannia glutinosa totally 45 days, execution take blood, measure superoxide dismutase (SOD), peroxide Change the content of hydrogen enzyme (CAT), glutathione peroxidase (GSH-Px) vigor and lipid peroxide (LPO).As a result Rehmannia glutinosa GSH-Px activity can be enhanced and reduce the content of LPO in serum, compared with the control group is respectively P < 0.05 and P < 0.01.(2) right The influence of hyperthyroidism type deficiency of Yin rat: rat is given with triiodo thryonine (T3) and causes yin-deficient model and awards Rehmannia glutinosa decocting Liquid 3ml (70% concentration), totally 6 days, then measures each data.As a result Normal group is compared with administration group, and no matter is medication front and back It is sign, weight change, 24 hours amounts of drinking water and urine volume and each associated hormone: T3, thyroxine (T4) and aldosterone (AD) Plasma concentration without significant difference (P > 0.05).But after modeling, deficiency of Yin group is compared with normal group, then has highly significant change Change, such as excited bellicose, weight loss, 24 hours amounts of drinking water and drink amount increase, and T3 concentration increases, and T4, AD concentration reduce etc..And it is negative Empty rat gives above-mentioned symptom and indices after Rehmannia glutinosa and significantly improves, and tends to normal (comparing with deficiency of Yin group).Such as the deficiency of Yin Rehmannia glutinosa group is added to compare with deficiency of Yin group, plasma A D concentration significantly increases (P < 0.05), and twenty-four-hour urine amount substantially reduces (P < 0.01), Prompt Rehmannia glutinosa has the function of that nourishing kidney yin is related with internal AD level is improved.T3, T4 concentration are bright in deficiency of Yin administration group blood plasma It is aobvious to improve (T3 concentration reduces, and T4 concentration increases), and tend to be normal.Show that Rehmannia glutinosa can not only be by making systemic adjusting With, improvement deficiency of Yin symptom, and abnormal thyroxine state can be played regulatory role.In addition deficiency of Yin administration group and normal group phase Than in terms of weight change, 24 hours amounts of drinking water, blood plasma T3, T4, being still significantly not up to normal level, having extremely aobvious It writes difference (P < 0.01).Although this shows that deficiency of Yin administration group is compared with deficiency of Yin group, indices are significantly improved and tend to just Often, but it is not completely recovered to normal.Illustrate that the effect of Rehmannia glutinosa still has limitation.(3) the experiment of Rehmannia glutinosa blood tonification effect is seen Examine: raw, ripe bosom glutinous rehmannia is made 1:1 water decoction stomach-filling and awards mouse observation to blood loss anemia, candidate stem cell and the red system of marrow The influence that hematopoietic progenitor cells CFU-E is generated.As a result: raw, ripe bosom glutinous rehmannia has apparent effect to blood loss mouse, after administration 8 days, Especially Rehmannia glutinosa group restores very fast, restores substantially, and P value is respectively 0.001 He compared with the control group for RBC and Hb counting 0.01.Raw, Rehmannia glutinosa also has certain proliferation, differentiation to candidate stem cell, like accountably yellow blood tonification effect and hematopoiesis Stem cell promotes the generation of haemocyte related.Generation to mouse bone marrow cells erythroid hematopoiesis group cell: physiological saline group erythroid colonies (number) is 52.4 ± 18.41, and Radix Rehmanniae and radix rehmanniae preparata group are respectively 60.2 ± 19.44 and 125 ± 20.45 (P < 0.05).Prompt ground Yellow blood tonification effect and medulla hematopoietic system also play the role of closely related.(4) the influence after glutinous rehmannia stir-fry charcoal to anastalsis: to life Every 100ml decocting liquid 100g containing crude drug or 33g containing charcoal drug preparation is respectively prepared in glutinous rehmannia, fresh rehmannia charcoal, Rehmannia glutinosa, charred RADIX REHMANNIAE.Each sample Mouse is awarded by 0.8ml/20g dosage stomach-filling, takes blood, statistics clotting time and and physiology salt from left eye endocanthion, ball rear vein beard Water group is compared.As a result difference that there are no significant (P > 0.05) prompts glutinous rehmannia not need seemingly to process for stopping blooding.
In terms of Radix Angelicae Sinensis, motherland's medicine thinks that Radix Angelicae Sinensis is sweet in flavor and weighs, therefore can specially enrich blood, and gas is light and pungent, thus again can promoting circulation of blood, Bowl spares has, has benefit in row, is the key medicine in blood.Thus, it can enrich blood and invigorate blood circulation, not only can promoting menstruation, but also can be active.It is all Menoxenia, dysmenorrhea, deficiency of blood amenorrhoea, sallow complexion, weak anaemia, uterine hemorrhage, postpartum blood stasis, example pass through (menstrual onset When, there are mouth and nose and bleed) etc. women common disease, angelica for treating can be used.Radix Angelicae Sinensis is that the most frequently used medicine in Chinese medicine is chiefly used in Baoshang is especially best to Anemic patients.It can also remarkably promote body hematopoiesis function, increase red blood cell, leucocyte and blood red Protein content.In terms of blood-supplementing blood-nourishing, Radix Angelicae Sinensis is sweet in flavor and weighs, therefore can specially enrich blood, and for the first medicine of enriching blood, is suitable for heart-liver blood deficiency and demonstrate,proves institute Pale or sallow complexion, fatigue and weakness, the lip and nail of cause it is light it is simple and unadorned, have a dizzy spell, the diseases such as palpitation and insomnia.It is Radix Angelicae Sinensis and radix rehmanniae preparata, white Chinese herbaceous peony, Rhizoma Chuanxiong compatibility, composition is enriched blood, and the side of representative --- " Siwu Tang " has the function of menstruation regulating blood nourishing medicinal, particularly suitable for the medical treatment of the postpartum deficiency of blood. In terms of relax bowel and defecation, Chinese medicine thinks essence and blood sharing the same origin, and deficiency of blood person's body fluid is also insufficient, the short easy cause constipation of intestinal juice.Radix Angelicae Sinensis can moisten Intestines defaecation often shares treatment blood deficiency and constipation with edestan, semen armeniacae amarae, rheum officinale；With radix saposhnikoviae, Rhizoma Chuanxiong, Chinese herbaceous peony, rheum officinale, dried peppermint leaf, Chinese ephedra It, can purgating heat and bowels Deng the composition Miraculous Power of Ledebouriella.In terms of regulating menstruation and activating blood, Radix Angelicae Sinensis gas is light and pungent, thus again can promoting circulation of blood, both can promoting menstruation tune Through, and energy active pain relieving, it is especially suitable for women and uses, is particularly suitable for the diseases such as irregular menstruation, dysmenorrhea, deficiency of blood amenorrhoea, by ancients Referred to as " gynaecology's panacea ".With peach kernel, safflower, Rehmannia glutinosa, Radix Paeoniae Alba, Rhizoma Chuanxiong compatibility, gynaecology's recipe --- Taohong Siwu Tang is formed, often Shift to an earlier date for menstrual period, dysmenorrhea.To the effect aspect of uterine smooth muscle, Chinese angelica volatile oil has inhibiting effect to isolated uterine, makes Rythmic contractions characteristic is in relaxation state, and fights uterine contraction.In terms of antitumaous effect, Radix Angelicae Sinensis can be widely used for various tumours, especially It is gynecological tumor, it is most suitable with qi and blood stagnation, hemostasis cohesion person.After thin to the deficiency of blood thin middle and terminal cancer or operation, radiotherapy, chemotherapy Radix Angelicae Sinensis can be selected, also with right supporting anticancer in the patient of deficiency of vial QI.Anti-ageing anti-old aspect, Radix Angelicae Sinensis decoction have learning and memory of little mouse There is apparent influence, measured with ㄚ maze method, Radix Angelicae Sinensis can improve dementia caused by alchlor, reduce the peroxide of dementia mice brain The activity for changing ester matter level and the oxidation of Type B monoamine, can treat senile dementia.In terms of anti-treating chilblain, although Chinese medicine thinks pernio Disease on the skin, do not stretch in fact by mostly ferritic YANG QI deficiency, exogeneous cold invasion, yang-energy, blood stasis due to accumulation of cold and cause.Therefore it is often adopted in treatment With it is warming channel and expelling cold, activate blood circulation and disperse blood clots, swelling and pain relieving.Chinese angelica, ginger mutton soup comes from " Treatise on Febrile and Miscellaneous Disease ".Chinese Angelica blood replonishing is invigorated blood circulation in side, The benefits of ginger warming yang for dispelling cold, mutton qi-restoratives green blood, full side's mutual aid nourshing blood and promoting blood circulation, warming yang for dispelling cold.In terms of immunization, Radix Angelicae Sinensis and its Extract sodium ferulate and Radix Angelicae Sinensis polysaccharide have apparent stimulation to monocytes/macrophages system, to immunologic hypofunction Body also has immune regulation and restitution.Radix Angelicae Sinensis also has facilitation to the lymphocyte transformation of Healthy People.Radix Angelicae Sinensis benefit is more, But the taboo of Radix Angelicae Sinensis is also more, and taking will notice.There are many crowd that can eat Radix Angelicae Sinensis, but have to take in right amount, otherwise, very It is easy to produce side effect.Excessive oral Radix Angelicae Sinensis decoction, powder occasionally have the reaction such as tired, drowsiness, can disappear after drug withdrawal.Radix Angelicae Sinensis volatilization Oily acupoint injection therapy can make patient the reaction such as fever, headache, dry, nausea occur, can voluntarily alleviate.Large dosage administration, will lead to Blood pressure decline, dosage increase then blood pressure rapid drawdown again, and breathing stops.Radix Angelicae Sinensis ether extract toxicity is stronger, can cause on a small quantity dead It dies.Clinical use Radix Angelicae Sinensis can not be excessive, it must also be noted that having no adverse reaction after medication.Thus, it is desirable to be taken by doctor's advice.
Radix Angelicae Sinensis has various pharmacological actions.(1) anti-thrombosis function, Radix Angelicae Sinensis aqua intravenous injection or oral to rat The formation of artery and venous bypass thrombus has obvious inhibiting effect.(2) improve blood circulation effect, the butylphthalide in Radix Angelicae Sinensis can Increase middle cerebral artery occlusion (MCAO) postoperative pial arteriole caliber and blood flow velocity, so as to improve soft bus wire. For During Ischemia there are Neuron Apoptosis, butylphthalide can also make the nerve cell apoptosis process of low sugar hypoxia inducible weaken or stop Only, brain infarction area is prevented to expand.(3) to the effect of cardiovascular system, Radix Angelicae Sinensis decoction or liquid extract have Isolated Toad Heart Inhibiting effect can make heartbeat stop at diastole when dosage is big.Radix Angelicae Sinensis has the arrhythmia cordis of rat myocardial ischemia and reperfusion Protective effect, Radix Angelicae Sinensis injection 0.6g/kg are used for rats by intraperitoneal injection, premature beat incidence and the total incidence of arrhythmia cordis can be made bright It is aobvious to reduce.(4) improve the effect of coronary circulation, intravenous injection Radix Angelicae Sinensis decoction (2g/kg) can dramatically increase coronary flow, reduce hat Arteries and veins resistance and myocardial oxygen consumption increase heart discharge and heartbeat index, mitigate myocardial infarct size when blocking coronary artery.(5) right The effect of smooth flesh, Radix Angelicae Sinensis have expansion blood vessel function and have mild spasmolysis to make vasopasm caused by norepinephrine (NA) With.Chinese angelica volatile oil is the dominant reactive part that Radix Angelicae Sinensis plays spasmolysis to vascular smooth muscle, and wherein Ligustilide activity is most strong. Chinese angelica volatile oil also has stronger inhibiting effect to intestinal smooth muscle spasm.(6) anti-inflammatory and analgesic activity, Radix Angelicae Sinensis is to a variety of proinflammatory agents Caused acute capillary permeability increases, tissue edema and chronic injury significantly inhibit effect, and can inhibit inflammation Later period granulation tissue hyperplasia, but the weight of adrenal gland and thymus gland is not influenced, prompt its anti-inflammatory effect independent of on hypophysis-kidney Glandular system.Radix Angelicae Sinensis water extract shows analgesic activity, analgesic activity intensity to writhing response caused by intraperitoneal injection acetic acid It is 1.7 times of sodium acetylsalicylate.(7) hypoglycemic effect, experiment shows that angelica powder (1.5g/kg) is oral, to rat and rabbit Experimental hyperglycemia has hypoglycemic effect, and hypoglycemic effect is realized by promoting the secretion of insulin.(8) to lung Protective effect, the expansible rat pulmonary artery of Radix Angelicae Sinensis, reduce Acute Hypoxic Pulmonary Hypertension in Anesthetized.Radix Angelicae Sinensis is to chronic obstructive pulmonary disease Pulmonary hypertension also have certain antihypertensive effect.(9) hepatoprotective and cholagogic effects, Radix Angelicae Sinensis can make solid matter weight and gallbladder in bile Acid output increases, and Radix Angelicae Sinensis can protect the activity of cell ATP enzyme, G-6-Pase, 5- nucleotidase, prompt it to guarantor Protect liver cell and the recovery certain functions of liver have certain effect.(10) to the protective effect of kidney, Radix Angelicae Sinensis has centainly kidney Protective effect, can improve Rabbit Kidney post-ischemic renal bead filtering function and reabsorption function, mitigate renal damage, promote The recovery of renal tubule lesion.(11) blood tonification effect, Radix Angelicae Sinensis polysaccharide can activate hematopoieticmicroenviron-ment by direct and (or) degradation pathways In macrophage, lymphocyte etc., muscular tissue can also be stimulated, promote its to generate the hematopoietic regulation factor, and then promotion functions are made Hemocytoblast granular leukocyte macrophage colony stimulates proliferation of Bone Marrow CFU-GM hematopoiesis at the Proliferation, Differentiation of unit (CFU-GM).In addition, working as Give back the effect of being presented below as: the effect to uterine smooth muscle, the effect to cardiovascular system, to the effect of hematological system, anti-inflammatory Effect, nervous system inhibiting effect, antibacterial action, antiasthmatic effect.In addition, Radix Angelicae Sinensis can treat muscle, close in terms of clinical application Pain and neuralgia are saved, chronic bronchitis is treated, treats chronic pelvic inflammatory disease, treats menopathy, treats high blood pressure, is treated band-like Bleb treats rhinitis.
Radix Codonopsis (scientific name；Codonopsis pilosula (Franch.) Nannf.) Campanulaceae Codonopsis, perennial herb Plant.The primary efficacy of Radix Codonopsis is tonifying Qi.Most preferably it is used for fatigue and weakness, lassitude usually.Voice is droning, conscious shortness of breath, slightly Once the Lung Qi deficiency weak person of movable syndrome characterized by dyspnea.Lay particular emphasis on the people of deficiency of spleen-QI and stomach-QI, weakness of limbs, loss of appetite, loose watery stool also preferably makes Use Radix Codonopsis.Common Radix Codonopsis and Rhizoma Atractylodis Macrocephalae, Poria cocos, radix glycyrrhizae preparata compatibility, here it is air making-up and spleen enlivening name prescription Sijunzi Tang.Lung qi with Temper all void, and preferably matched with Radix Codonopsis and Radix Astragali, Rhizoma Atractylodis Macrocephalae, Poria cocos, dried orange peel, Radix Angelicae Sinensis, cimicifugae foetidae, radix bupleuri, radix glycyrrhizae preparata, ginger, jujube 5, here it is famous Buzhong Yiqi Tangs.
Radix Codonopsis tonifying Qi and energy blood-nourishing, this is its a big feature.So qi-blood deficiency, shortness of breath and palpitation, lassitude and weak, complexion It is pale, it feels dizzy, has no appetite, defecate dilute soft, easy to catch cold people, also preferably takes Radix Codonopsis.It is demonstrated experimentally that Radix Codonopsis can make it is red It is cytosis, blood redEggWhite increase, so anaemia patients Radix Codonopsis is very helpful.Because white thin caused by chemotherapy and radiotherapy Born of the same parents' decline, taking Radix Codonopsis also has the effect for promoting leucocyte to go up.In recent years it has also been found that, Radix Codonopsis can make slow with Radix Astragali, Rhizoma Atractylodis Macrocephalae cooperation Property nephritis victim Urine proteins reduce.
The effect of Radix Codonopsis includes various aspects.Specifically, the influence of (1) to haemocyte: alcohol, the aqueous extract of radix codonopsis root are oral Or subcutaneous injection, the red blood cell of normal rabbit and hemoglobin can be made to be increased slightly；After extracing spleen, effect is obviously reduced, therefore is pushed away Its blood tonification effect is surveyed, may be related with spleen, leucocyte is then reduced tendency at this time.Radix Codonopsis immersion liquid 1:40 is in vitro without haemolysis Phenomenon, but with after red blood cell effect, muddy, precipitating occurs for changeable colour.(2) to the influence of blood glucose: to rabbit abdominal part hypodermic party Join medicinal extract, blood glucose rise can be made；But it is such as the medicinal extract or gastric infusion after injection fermentation, then incomparable to act on, therefore think that it increases blood Sugar be because of sugar containing volume in root caused by；It can not inhibit the nerve hyperglycemia occurred because injecting diuretin.According to preliminary Test, northern Radix Codonopsis stomach-filling can increase blood glucose.(3) antihypertensive effect: alcohol, aqueous extract vein or intraperitoneal injection can reduce anesthetized dog Blood pressure, according to preliminary analysis, it is believed that belong to peripheral；And there are certain adrenolytics；Its infusion or alcohol, water logging go out Liquid also plays the role of reducing anesthetized animal blood pressure, and can inhibit Isolated Toad Heart.To chronic hypertension dog, water logging is gavaged daily 4 grams of liquid (crude drug)/kilograms, it there are no antihypertensive effect.The extract or general glycoside of the root of congener feed rabbit in long-term (40 days), can Increase red blood cell and apply (17.5%), puts on weight (23%)；There are prevention and treatment function to leukocytosis caused by turpentine oil Effect；What pathological change Long-term Oral, internal organs find no.(4) to the effect of maincenter: Radix Codonopsis decoction can fight nitric acid scholar's Mice convulsion caused by peaceful extends the time fainted from fear and occurred, extends the time-to-live of mouse, also there is confrontation electrofit effect.Party Join mouse memory acquired disturbance caused by the significant confrontation hyoscine of decoction energy；Also have to ethyl alcohol induced mice reproducibility dysmnesia Antagonism.(5) to cardiovascular effect: alcohol immersion liquid and infusion have antihypertensive effect, and antihypertensive effect is due to peripheral blood Caused by enlargement of pipe, ethanol extract has inhibiting effect to Isolated Toad Heart.(6) to the effect of blood: Radix Codonopsis hydrotrope stomach-filling, it is right The rat platelet aggregation of ADP induction has inhibiting effect.Commodity Radix Codonopsis can make the significant increase of the red blood cell of rabbit, and leucocyte is obvious It reduces.(7) anti-ulcer effect: Radix Codonopsis has confrontation gastric mucosa damage and enhancing gastric mucosal cell protective effect.(8) to immune function The influence of energy: Radix Codonopsis decoction can be obviously promoted the biosynthesis of the splenic lymphocytes DNA and protein of ConA activation, to leucocyte Effect is also remarkably reinforced in the generation of medium -2 (IL-2).Also there is humidification to the phagocytic function of mouse reticuloendothelial system. (9) endurance and oxygen lack resistant function: Radix Codonopsis water decoction can extend the mice burden swimming time；And it can dramatically and extend hypoxia mice Time-to-live.
Donkey-hide gelatin have enrich blood, stop blooding, enriching yin, the effect of moisturizing.Main syndrome of blood deficiency, consumptive disease hemoptysis, haematemesis, hematuria, hematochezia, blood Dysentery, gestation hemorrhage, metrorrhagia and metrostaxis, deficiency of Yin vexed insomnia, deficiency syndrome of the lung bath cough, the convulsion of endogenous deficient wind are fainted twitch.The effect of donkey-hide gelatin has Zhu Duofang Face.For example, the effect of (1) to hemopoietic system: donkey-hide gelatin has powerful blood tonification effect, and curative effect is better than chalybeate.(2) Antishock function: The blood pressure of extremely low level can be made to restore to normal level, and effect is more lasting.(3) to the shadow of progressive trophism myodegeneration disease It rings: the trophism progressive myodegeneration disease of similar people can occur in cavy test.(4) to the influence of calcium metabolism: there is positive calcium balance Effect, this is also advantageous to myodegeneration disease patient.Illness caused by mainly being treated with donkey-hide gelatin because of the deficiency of blood on tcm clinical practice.With people The raising of quality of life, civil more and more people are kept fit and healthy with donkey-hide gelatin, beautifying face and moistering lotion.(1) blood disease is treated: treatment iron deficiency Property anaemia, alpastic anemia, decrease of platelet, the diseases effect such as oligoleukocythemia is obvious, treatment anaemia contain in donkey-hide gelatin Patent medicine has: Donky-hide blood-supplementing tonic, semifluid extract of Shandong donkey-hide gelatin, complex prescription glue mucilage, Angelicae Bolus for Nourishing Blood etc..(2) prevent miscarriage miscarriage prevention: donkey-hide gelatin is also used In gestational period threatened abortion, threatened abortion, habitual abortion.(3) menopathy: donkey-hide gelatin is based on nourishing yin and supplementing blood, and dissolving stasis blood, and There is certain haemostatic effect.For menopathy, deficiency of blood person can use donkey-hide gelatin help, and the more persons of blood are used to take the photograph admittedly, and blood lacks person for promoting circulation of blood. (4) hemorrhage: through compatibility, donkey-hide gelatin can be used for the treatment of a variety of haemorrhages, such as haematemesis, hematochezia, blood urine, menorrhalgia, metrorrhagia and metrostaxis and Blood etc. under postpartum.(5) disease of old people and anti-aging are prevented and treated: clinically giving full play to the blood-nourishing of donkey-hide gelatin, enrich blood, the effect of QI invigorating, For recuperating under medical treatment a variety of geriatric diseases, such as menopausal syndrome, insomnia, sick sinus syndrome, low blood pressure, diabetes, wind Wet arthritis, osteoporosis, senile dementia etc..(6) cancer-resisting: showing and improve tumor patient lymphocyte transformation rate, Inhibit tumour growth, changes the toxicity for subtracting other anticancer drugs and chemotherapy, make it possible to finished chemoradiotherapy process.Tcm clinical practice Upper common donkey-hide gelatin is equipped with other drugs treatment leukaemia, nasopharyngeal carcinoma, cancer of the esophagus, lung cancer, breast cancer etc..(7) it builds up health and beautiful Hold: donkey-hide gelatin is not not warm dry, suitable for people of all ages, available throughout the year, is the excellent tonic product to keep fit and healthy.So far Shanghai, Jiangsu, Many family's winters in Zhejiang are equipped with rock sugar, walnut kernel, Semen sesami nigrum, longan, jujube etc. again with donkey-hide gelatin and are made into thick paste, and morning and evening temperature is opened Mixing in water for oral taking feels have strength, cold hardiness enhancing, flu few with it after.Pregnant woman takes donkey-hide gelatin and be conducive to children's in antenatal postpartum The recovery of growth and postpartum body.Donkey-hide gelatin is rich in protein degradation ingredient, plays the role of skin care by enriching blood, is conducive to The health care of skin can make to have rosy cheeks after use, and skin is delicate, and glossy, elasticity is good, and has certain abnormal pigmentary deposit on the skin effect of dispelling, institute Also to skin-protecting face nursing.Donkey-hide gelatin is widely used in Chinese medicine formula and civil, is also largely used to Chinese patent drug production.Country in 2000 There are 181 kinds to contain donkey-hide gelatin in the Chinese patent drug of approval.
Ferrous gluconate, molecular formula C12H22O14Fe2H2O, relative molecular mass 482.18.In food It can be used as color stabilizer, nutrition fortifier, it can be by being formed in reduced iron with gluconic acid.The characteristics of ferrous gluconate is biological benefit With rate height, dissolubility is good in water, and the gentle no astringent taste of flavor is strengthened more in milk beverage.Ferrous gluconate is as a kind of Excellent iron supplementary, ferrous absorption rate is high, after entering blood, is oxidized to ferric ion at once, and with blood plasma transfer iron egg White combination, at blood plasma iron, and using transferrins as carrier transport to liver, spleen, the tissue such as bone is stored in the form of ferritin, in bone The iron of middle ferritin is combined into hemoglobin, becomes myoglobins in skeletal muscle, and in iron deficiency, plasma iron transport rate increases Add, absorptivity also accelerates, and increases iron uptake.Ferrous gluconate is mainly through enteron aisle, skin excretion, on a small quantity through bile and sweat Middle excretion.Ferrous gluconate is identical as ferrous sulfate, participates in the synthesis of hemoglobin, in transmitting oxygen and body metabolism activity It plays an important role.Ferrous gluconate adapts to symptom and is mainly used for because of chronic blood loss, menorrhalgia, pregnant woman, breast feeding women, Hypoferric anemia caused by the child development phase.
Product of the present invention formula is with the comprehensive utilization of two constituents, in the hope of better effect；This product is oral liquid formulations, tool Have the advantages that absorb it is fast, prove effective that rapid, easy to use, quality is stable, portable, easy to maintain and dose is more acurrate, will get over More to have been favored by people.Therefore, to Hai Ruikang board blood, your red oral solution is researched and developed to meet the market demand, will be had There are vast market prospect and far-reaching social benefit.
Anaemia is lowered by systemic cell total amount or hemoglobin total amount, and causing blood function of carrying oxygen deficiency is coexpress A kind of hematologic disease, motherland's medicine thinks: the generation of blood and the relationship of spleen are most close, therefore "Nei Jing" has that " middle coke, which is bullied, to be taken Juice variation and it is red be meaning blood "；Miraculous Pivot " taste are insufficient, are all blood disease "；The discussion of " spleen rib opinion ", if taste are deficient, function is lost It adjusts, then trough storage is insufficient, and the weary source of cereal nutrient or cereal nutrient are absorbed and utilized obstacle, then influence the generation of blood.Nutrition Property anaemia is due to malnutrition, and hematopoietic disorders cause, and hypoferric anemia belongs to the column of alimentary anemia.Clinical doctor trained in Western medicine mostly uses product Primary disease is treated in pole, prevents excessive blood loss, and the methods of desinsection and supplement chalybeate treat this disease；Chinese medicine is then with benefiting qi for promoting production of blood Basic principle symptom complex " dialectical plus-minus ", impose tonify the liver and kidney, be tonifying spleen and kidney, strengthening the spleen and replenishing qi, the methods such as supplementing qi and nourishing yin.This formula It is to be pressed with reference to the proved recipe for improving anaemia at all times in conjunction with the latest developments that modern medicine is studied using motherland's medicine theory as foundation Principle is put according to theory of traditional Chinese medical science group to form.The red oral solution of Hai Ruikang board Xue Er is according to such mechanism of action, and the purpose is to supplement For human body due to a lack of nutriment necessary to green blood, prevention makes hemoglobin formation or anerythropoiesis, leads to hematopoiesis function It can be low.It is Radix Astragali, the gas of big tonifying spleen internal organs, as a means of source of generating QI and blood in this formula；Radix Angelicae Sinensis, Gan Xin and warm, blood-nourishing and battalion, sun Raw yin is long, and the prosperous blood of gas is raw；Donkey-hide gelatin, Rehmannia glutinosa nourishing yin and nourishing blood, Radix Codonopsis benefiting qi and nourishing blood；Prevent the gluconic acid of hypoferric anemia sub- Iron.
In the formula of the present composition, Radix Astragali has the function of improving cardiovascular and cerebrovascular, mitigates the heart as caused by ischemic Calcium accumulates in myocyte, cardiac muscular tissue and red blood cell, and can protect Erythrocyte Calcium pumping function, to mitigate caused by hypoxic-ischemic Myocardial ultrastructure changes.Radix Angelicae Sinensis can increase Peripheral Erythrocytes, leucocyte, hemoglobin and bonemarrow nucleated cells number.Rehmannia glutinosa Improving immunocompetence has the effects of anti-aging, antitumor, calm, anti-radiation, anti-oxidant, to protein metabolism, sugared cortex Hormone, blood glucose etc. have an impact.Radix Codonopsis has anti-oxidant, and the quantity of phatidylcholine is promoted to increase, and improves memory, promotes red blood cell raw At expansion capilary increases the effect of blood flow.Donkey-hide gelatin has certain effect to hemopoietic function of bone marrow, can restore rapidly blood loss The hemoglobin and red blood cell of anaemia have powerful blood tonification effect.Ferrous gluconate has synthesis hemoglobin, synthesizes flesh Lactoferrin, synthesis storage iron etc.；It is the confactor for required composition or the activation certain metalloenzyme and it for constituting various metalloenzyme.
One of anaemia harm the most fundamental to health is exactly that oxygen carrying capacity is low, influences the hair of each system function of whole body It waves, a series of common symptons and sign is caused to influence life, the life quality of people.The present composition is with donkey-hide gelatin, Rehmannia glutinosa It is used as medicine, sweet temperature is rich, and matter is soft and moist, is longer than nourishing yin and nourishing blood, Radix Angelicae Sinensis, replenishing blood and nourishing liver, regulating menstruation by adjusting the flow of blood, and blood is tangible object, gas category Invisible to be used, the operation of blood depends on gas, therefore with Radix Codonopsis, the gas of the big tonifying spleen lung of Radix Astragali, as a means of source of generating QI and blood.Glucose It is sour ferrous for benefit iron.Suitable for alimentary anemia person.Since its formula is unique, product safety is nontoxic, and healthcare function is clear, hair Exhibition has a extensive future.Its raw material of the present composition is easy to get, rational technology, production cost is low, dosage form is reasonable, easy to carry, is suitble to Middle and low income group.It is therefore contemplated that this launch have extensive development prospect, will generate huge social benefit and Good economic benefit.
Radix Astragali in the side of the traditional chinese medicine composition of the invention, the gas of big tonifying spleen lung, as a means of source of generating QI and blood；Radix Angelicae Sinensis, Gan Xin and Temperature, blood-nourishing and battalion, Yin grows while yang is generating, the prosperous blood of gas are raw；Donkey-hide gelatin, Rehmannia glutinosa nourishing yin and nourishing blood, Radix Codonopsis invigorating qi and benefiting blood；Ferrous gluconate is mended Iron.Effect: benefiting qi and nourishing blood, nourishing yin and nourishing blood.Healthcare function: improve alimentary anemia.Radix Astragali is leguminous mongolian scutellaria or film The dry root of pod Radix Astragali.Contain astragalin, astragalus polyose, choline, sucrose, flavones, a variety of amino acid, bitter principle, leaf in Radix Astragali Acid, flavane compound and contain various trace elements, Daucosterol, the soyasaponins such as selenium, silicon, zinc, cobalt etc..Nature and flavor: sweet, micro- Temperature；Returns spleen, lung channel；Function: tonifying Qi and lifting yang, invigorating qi for consolidating superficies, promoting pus discharge and tissue regeneration, profit water detumescence.Cure mainly and apply: Radix Astragali is wanted for tonifying Qi Medicine, raw Radix Astragali walk table, relatively strengthening exterior and reducing sweat, pus draining and toxin expelling；In toast is then walked, tonifying Qi and lifting yang, inducing diuresis for removing edema are focused on.When being classified as umbrella shape The root of section's herbaceos perennial Radix Angelicae Sinensis.Radix Angelicae Sinensis is used as medicine long-standing, and being just listed in it early in Shennong's Herbal can attack and can mend Middle product medicine, not only can righting take a tonic or nourishing food to build up one's health, but also heresy can be attacked and cured the disease, primary effect of Radix Angelicae Sinensis is to enrich blood.Contain ferulic acid, a variety of in Radix Angelicae Sinensis Amino acid, Radix Angelicae Sinensis polysaccharide, pyrimidine, purine, vitamin B12, vitamin E, linoleic acid, succinic acid, niacin etc., and it is micro- containing manganese, zinc etc. Secondary element contains volatile oil.Nature and flavor: sweet, pungent, warm；Return heart, liver, the spleen channel；Function: replenishing and activating blood, menstruction regulating and pain relieving, relax bowel and defecation. It cures mainly and applies: 1. controlling Blood deficiency, it is effective to control syndrome of blood deficiency with using for normal Compatibility with Radix Astragali.It is woman 2. controlling irregular menstruation, amenorrhoea, dysmenorrhea Section's menstruation regulating key medicine.Rehmannia glutinosa is the root of Scrophulariaceae herbaceos perennial glutinous rehmannia.Contain sitosterol in Rehmannia glutinosa, mannitol, lack Measure stigmasterol, rehmanin, Catalpol, dihydro Catalpol, acyl Catalpol, Daucosterol, rehmannioside, monoterpene and glucoside, also containing organic acid, Glucose, sucrose, fructose, raffinose, sweet dew triol, galactolipin, vitamin A, a variety of amino acid, various trace elements.Nature and flavor: Sweet, tepor；Channel tropism: enter liver and kidney channel；Effect: nourishing the blood and yin, enriching essence and nourishing marrow.It cures mainly and applies: 1. controlling blood deficiency chlorosis, dizziness, the heart Throb with fear, have a sleepless night, irregular menstruation, the diseases such as metrorrhagia and metrostaxis.2. the deficiency of the kidney yin is controlled, hectic fever, night sweat, the diseases such as pass out semen, quench one's thirst.3. all soreness of waist feet are soft, The disease of dizzy, Hiccough and deaf, all blood and essence asthenias such as poliosis can apply.Radix Codonopsis is the dry of Campanulaceae Radix Codonopsis plant Dry.Contain stigmasterol, saponin, synanthrin, choline, codopiloic acid, Syringin, nicotine, amino acid, microelement and dimension in Radix Codonopsis Raw element B1、B2, volatile oil etc..Nature and flavor: sweet and neutral；Channel tropism: enter spleen, lung channel；Effect: tonifying middle-Jiao and Qi, stomach function regulating of promoting the production of body fluid.It cures mainly and answers With: for treating qi deficiency, symptoms include in shortness of breath and palpitation, the tired inability of body eats loose stool less, the edema of the face, rush down prolapse of the anus for a long time, and body fluid deficiency tongue is dry Thirsty disease.1. anaemia: compatibility Radix Codonopsis, Radix Astragali, donkey-hide gelatin, deer horn glue, arillus longan, Rhizoma Atractylodis Macrocephalae, Radix Angelicae Sinensis, jujube etc..2. because of chemotherapy or putting Leukopenia caused by treating: compatibility Radix Codonopsis, Radix Astragali, Caulis Spatholobi, the fruit of glossy privet, Herba Epimedii, Rhizoma Atractylodis Macrocephalae, Chinese yam, deer horn glue etc..Ah Glue is the skin of equid donkey, through blob of viscose made of drift bubble unhairing tanning.Donkey-hide gelatin contains gelatin, gelatine, nitrogenous 16.43%~ 16.54%, multiple proteins, amino acid, calcium and sulphur etc., wherein lysine, arginine, histidine etc..Nature and flavor: sweet, flat；Return Through: enter lung, liver and kidney channel；Function: tonifying the blood and arrest bleeding, nourishing Yin and moistening lung.Cure mainly and apply: the key medicine 1. enriched blood controls dizziness due to deficiency of blood, the heart Grade of throbbing with fear diseases are mostly used together with qi-replenishing and blood-enriching medicines such as Radix Codonopsis, Radix Astragali, Radix Angelicae Sinensis, radix rehmanniae preparatas.2. key medicine of stopping blooding, for spitting blood, bleeding from five sense organs or subcutaneous tissue, hematochezia, Metrorrhagia and metrostaxis, be applied alone or compatibility Pu Huang, Radix Rehmanniae, charred FOLIUM ARTEMISIAE ARGYI etc. all effectively.3. the diseases such as the vexed, insomnia of the deficiency of Yin are controlled in enriching yin of enriching blood.Glucose Sour ferrous iron is to belong to multi-nutrient fortification agent, iron-content 11%.Intracorporal iron can be divided by its function must be with nonessential two parts. The 70% of internal iron total amount must be partially accounted for, hemoglobin, myoglobins, ferroheme enzyme, confactor and transport are present in In iron；Non-essential parts are then used as cylinder storage iron, and liver, spleen and bone are mainly present in the form of ferritin and hemosiderin In marrow.Iron is the most abundant a kind of indispensable element of content in human body, can synthesize hemoglobin, and is to constitute various metalloenzyme Required required composition can participate in the synthesis of hormone or the work of enhancing hormone for activating certain metalloenzyme and its confactor With, have and safeguards the normal immune function of body, the function of the sterilization of enhancing neutrophil leucocyte and phagocytosis.Hypoferric anemia is global Disease, World Health Organization's investigation result disease incidence adult male 10%, women 40%, and children 50%；China report women and Child morbidity highest.Many enzymes due to participating in body metabolism contain iron, and when old friend's body iron deficiency, many enzymatic activitys reduced, and cause A variety of metabolic disorders, to influence the function of multiple organs.Iron is the most abundant microelement in human body, many iron enzyme controls The important oxidation of body, hydrolysis and conversion process, therefore with tissue resorption, oxidative phosphorylation, porphyrin metabolism, collage synthesis, Lymphocyte and granulocyte function, neurohumoral synthesis and Fen Xies, body are related with the development of nerve fiber.Hypoferric anemia When, while hemoglobin, myoglobins, ferritin, hemosiderin etc. reduce, many iron enzymes or iron rely on enzymatic activity drop It is low, electron transport system is influenced, lipid, protein and abnormal carbohydrate metabolism can be caused, seriously affects being normally carried out for organism metabolism, Iron deficiency can cause Various Tissues change and function changes tune, and bone marrow nucleated cell DNA and rna content are reduced.Anaemia is thin by whole body Born of the same parents' total amount or hemoglobin total amount lower, and causing blood function of carrying oxygen deficiency is a kind of hematologic disease of coexpress, motherland doctor Medicine is thought: the generation of blood and the relationship of spleen are most close, thus "Nei Jing" have " middle coke be bullied take juice change and it is red be meaning blood "；" spirit Pivot " " taste are insufficient, are all blood disease "；The discussion of " spleen rib opinion ", if taste are deficient, functional disturbance, then trough storage is insufficient, precise and tiny Obstacle is absorbed and utilized in the weary source of substance or cereal nutrient, then influences the generation of blood.Alimentary anemia is due to malnutrition, hematopoiesis Obstacle causes, and hypoferric anemia belongs to the column of alimentary anemia.Clinical doctor trained in Western medicine mostly uses active treatment primary disease, prevents excessive Blood loss, desinsection and supplement the methods of chalybeate treat this disease；Chinese medicine is then " dialectical to add by basic principle symptom complex of benefiting qi for promoting production of blood Subtract ", impose tonify the liver and kidney, be tonifying spleen and kidney, strengthening the spleen and replenishing qi, the methods such as supplementing qi and nourishing yin.This formula be with motherland's medicine theory be according to According to, with reference to the proved recipe for improving anaemia at all times, in conjunction with the latest developments that modern medicine is studied, put principle according to theory of traditional Chinese medical science group and At.The red oral solution of Hai Ruikang board Xue Er be according to such mechanism of action, the purpose is to supplement human body due to a lack of green blood institute it is required Nutriment, prevention make hemoglobin formed or anerythropoiesis, cause hematopoiesis function low.It is yellow in this formula Stilbene, the gas of big tonifying spleen internal organs, as a means of source of generating QI and blood；Radix Angelicae Sinensis, Gan Xin and warm, blood-nourishing and battalion, Yin grows while yang is generating, the prosperous blood of gas are raw；Ah Glue, Rehmannia glutinosa nourishing yin and nourishing blood, Radix Codonopsis benefiting qi and nourishing blood；Prevent the ferrous gluconate of hypoferric anemia.
Insufficiency of vital energy and blood refers to the deficiency of vital energy and the deficiency of blood in traditional Chinese medicine.Chinese medicine thinks that " gas ", " blood " are to constitute and maintain human body raw Movable base substance is ordered, spring is easy sleepiness just because of asthenia of qi and blood, and blood-nourishing, therefore the people of can just fostering the spirit of nobility that sleep It is more snoozed than other seasons.The people of the deficiency of vital energy, is easy to produce feeling of fatigue, cannot adhere to work, and four limbs are usually out of strength.Chinese medicine is to qi and blood Insufficient understanding: gas is to operate in a kind of intracorporal cereal nutrient of people.Energy with extremely strong energy, excitation and promotion machine The functional activity of body organ, therefore also represent the gas of QI of five ZANG-organs and passages through which vital energy circulates.The effect of gas is mainly the feeding body of temperature and resists outer Evil invasion, simultaneously participates in the metabolism of viscera function.Blood is the red liquid flowed in passages through which vital energy circulates.The function of blood has two sides Face.First, raising internal organs body channels and collaterals and bone key.Blood Sheng Ze shape is strong, and flushing profit, skin smooth, hair are moist, joint is clever It is living.Second, blood is the material base of cerebration.It is blood Sheng Ze spirit and QI cleaning, resourceful.Blood deficiency is then absent-minded, the heart Throb with fear uneasiness.The result of insufficiency of vital energy and blood will lead to the decline of viscera function, cause early ageing.The deficiency of vital energy, that is, viscera function decline disease resistance Difference shows as aversion to cold and cold limbs, spontaneous perspiration, dizziness and tinnitus, apathetic, tired inability, shortness of breath and palpitation, hypoevolutism.The deficiency of blood is visible Lusterless complexion is sallow, dry skin, hair are withered, nail is dry and cracked, blurring of vision, numb in every limb, insomnia and dreamful sleep, amnesia palpitaition, It is absent-minded.Insufficiency of vital energy and blood category QI and blood being ill simultaneously.Deficiency of qi and blood then can body dystrophy, with spiritlessness and weakness, shortness of breath lazyness speech, pale white complexion Or it is sallow, have a dizzy spell, lip and nail color is light, palpitation and insomnia, pale tongue weak pulse etc. are common syndrome.Common disease factor is: deficiency of QI causing insufficiency of blood, Prolonged illness is felt frustrated hematozemia, and causes deficiency of qi and blood.Common sympton is: aversion to cold and cold limbs, spontaneous perspiration, dizziness and tinnitus, tired inability, palpitaition etc.. Qi and blood is the material base for safeguarding body normal function, and gas can push blood operation, and blood can deliver gas, and qi and blood is mutually grown It is raw, the few then deficiency of vital energy of deficiency of QI causing insufficiency of blood, blood.Prolonged illness is felt frustrated hematozemia, and causes deficiency of qi and blood.The clinical manifestation of insufficiency of vital energy and blood is mainly, Insufficiency of vital energy and blood has a delicate constitution, the deficiency of vital energy then aversion to cold and cold limbs, spontaneous perspiration, dizziness and tinnitus, tired inability, shortness of breath and palpitation, hypoevolutism.Blood Empty visible lusterless complexion is sallow, dry skin, hair is withered, nail is dry and cracked, blurring of vision, numb in every limb, insomnia and dreamful sleep, amnesia It is palpitaition, absent-minded.Insufficiency of vital energy and blood then spiritlessness and weakness, shortness of breath lazyness speech, pale white complexion or it is sallow, have a dizzy spell, lip and nail color is light, the heart Insomnia, the feminine menstrual amount of throbbing with fear are few, delay or amenorrhoea, pale tongue weak pulse.The main symptom of deficiency of qi and blood: the few China of sallow complexion, deficiency of QI with disinclination to talk, Fatigue and weakness is had a dizzy spell, and palpitation and sleeplessness, deficiency of food is indigestion and loss of appetite, pale tongue, soft and thready pulse.It can judge qi and blood not in terms of following Foot: 1. eyes: the color and clarity of eyes, the color of the white of the eye become muddy, jaundice, have the trace of blood, show insufficiency of vital energy and blood.2. skin Skin: skin is white inner pink, it is glossy, elastic, without wrinkle, without spot, the qi and blood for representing lung is sufficient.Pachylosis there is not gloss, It shades, turn to be yellow, whitening, pastiness, rubescent, long spot, showing that physical condition is bad, insufficiency of vital energy and blood.3. hair: the speed of growth of hair With liver blood correlation, if deficiency of liver-blood, hair grows slow, hair and dries up hair loss, and hair turns to be yellow, whitens, jag, shows qi and blood not Foot, the decline of liver blood kidney qi.4. gum: gum is related to stomach and intestine, and gingival atrophy represents insufficiency of vital energy and blood.5. nail: not having on finger There is semilune on semilune or only thumb, longitudinal grin occur on nail, illustrates internal cold air weight, qi-blood deficiency, overdraw, It is the symbol of senility of humanbody.6. finger: finger pulp loss is full, and how flexible meat is, illustrates qi and blood abundance；Finger pulp loss is flat, thin Weak or finger tip is fine, then represents insufficiency of vital energy and blood.7. sleeping: falling asleep, fast, sleep is heavy, eupnea, and a feel wakes up naturally, and says Bright qi and blood foot；Difficulty falling asleep, easily frightened easily to wake up, frequent urination at night breathes very grave or snores, shows deficiency of qi and blood.8. movement: when movement Occur uncomfortable in chest, shortness of breath, fatigue be difficult to the state restored, then show insufficiency of vital energy and blood.9. the temperature of hand: qi and blood abundance hand is warm 's；It is all the performance of insufficiency of vital energy and blood if palm of the hand partial heat or perspiration or hand are cold.Briefly, insufficiency of vital energy and blood, the deficiency of vital energy embody It is nervous for movement asthma, movement, and the deficiency of blood is presented as that complexion turns to be yellow, whitens, giddy is nervous, feel not sleep well.
Aging, refer to body the physiology and psychological fitness progressive of environment are reduced, gradually phenomenon deathward.It declines Two classes: physiological aging and pathological seaility can be divided into always.The former refers to the physiological degenerative process occurred after the maturity period, Hou Zheshi The senile variation caused by various foeign elements (including various diseases).The two is practical to be difficult to distinguish.In short, aging is The inevitable outcome of many pathology, physiology and noematic comprehensive function is the biology heart of individual growth development final stage Electrophysiologic procedure.Said from biologically, aging be biology over time, spontaneous necessary process, it is complicated nature Phenomenon shows as the decline of the degeneration variation and function of structure, adaptability and resistance decline.In a physiologically, aging Regard as and is performed until old ontogeny since fertilized eggs.From pathology, aging is stress and to strain, damage And infection, immune response decline, trophic disturbance, the result that dysbolism and carelessness and drug abuse accumulate.In addition from society It is seen on, aging is that individual loses interest to fangle, detaches oneself from reality, likes missing old times or old friends.Occur with life, in development process A kind of activity, be body from the forfeiture and degenerative process for constituting substance, institutional framework to physiological function.Aging course be from by To what is persistently occurred between death, the feature for only having arrived certain stage aging just displays smart ovum obviously.People Physiological change in body aging course is mainly reflected in body tissue cell and constitutes the forfeiture of substance, and organism metabolism rate subtracts It is slow, body and decreased organ function.Aging is inevitable, but it is possible for delaying senescence.Reasonable diet, balanced nutrients It is one of anti-aging, the important measures for extending the service life.The major physiological performance of aging is: (1) metamorphosis.It include: 1. thin Born of the same parents' variation.It is mainly shown as gradually reducing for cell number.2. the variation of tissue and organ.Due to the cell of internal organs and tissue Quantity is reduced, so that atrophy, weight saving occur.3. overall variation.With advancing age, the bodily form and shape change, As hair bleaches；Skin elasticity reduces, and wrinkle occurs, senile plaque occurs；Tooth mobility falls off, deafness, dim eyesight, hunchback, height It is gradually shortened.(2) physiological function declines.It include: the decline of 1. systema cariovasculare functional.Such as cardiac muscle fibre gradually atrophy, the heart Age pigment (lipofuscin) deposits in myocyte, and heart valve becomes plump hardening, elasticity reduces etc..2. respiratory apparatus aging.Table It is now reduced for lung volume, respiratory function obviously declines, and compensatory capacity reduces.3. the variation of digestive system.Mainly oral cavity, stomach and intestine Atrophic variation occurs for miopragia, gum, tooth.4. muscle skeleton kinematic system changes.It is mainly manifested in and increases with the age, Muscle fibre attenuates, elasticity reduces, convergent force weakens；Organic component is reduced in bone, and inorganic salts increase, thus cause the elasticity of bone Toughness reduce, easily fracture etc..5. nervous system changes.It is mainly shown as the forfeiture to a certain degree of brain cell；Nerve conduction Speed reduces；The slow movement of the elderly, reflection flexibility decrease etc..(3) primary sensing organ's hypofunction.Such as vision is listened Feel, smell, the sense of taste, dermal sensation (including tactile, the sense of heat, pain sensation) decline.In addition, the elderly's psychokinesis reflects also phase It is slow to answer.Aging itself has 6 big characteristics, 1. generality: i.e. aging can all occur for all living things body.2. internality: aging course It is necessary process spontaneous in organism, is that live in optimum environment also can gradually aging.3. progressive: aging is The process continued to develop over time.4. harmfulness: aging reduces the physiological function of organism, increases sick With dead chance.5. individual difference: in same class biology, the process of aging is different between Different Individual, is especially existed The later period of life, this otherness become apparent.Only the slower individual of those agings is possible to obtain long-lived.6. may interfere with Property: although aging is inherent spontaneous process, but external condition can accelerate or delay the progress of this process.Such as environment temperature It can change the service life of animal.Just because of this, people are possible to seek longevity by bettering people's living environment.Angle of physiology It sees, aging is as caused by metabolism decline.Metabolism is one of essential characteristic of vital movement, it includes synthesis generation It thanks and two aspect of catabolism.If the anabolism of body be higher than catabolism, people will growth and development, here it is boyhoods And the adolescence；If the speed of the two metabolic processes is in a basic balance, people has arrived midlife and mature stage, this period human body Variation it is smaller；If catabolism is higher than anabolism, people begins to aging, if metabolism once stops, the life of people Life activity also just finishes.People in life, above-mentioned variation is generally existing, therefore aging is inevitable.But People in life, due to inherent or external, occur that aging course ahead of time, here it is early ageing.Early ageing is that pathology is old Change, it will affect the service life of people.Although people is easy to happen pathologic aging to the senescence phase, but not everyone must will send out It is raw.Therefore physiological aging to be inevitable the natural law, and what pathologic aging then can be prevented from and postpone.In order to same Aging is waged a struggle, and people once conducted extensive research the mechanism of aging.But up to now in relation to causing the machine of aging System not yet satisfies oneself.Briefly, the apparent external embodiment of aging is: poor physical capacity, easily insomnia, Hearing, taste weigh, High blood pressure, alopecia etc..
The present invention is by largely testing, it was confirmed that technical solution of the present invention presents one or more unexpected beneficial Effect.
Specific embodiment
The present invention can be further described by the following examples, however, the scope of the present invention and unlimited In following embodiments.One of skill in the art, can be with it is understood that under the premise of without departing substantially from the spirit and scope of the present invention Various change and modification are carried out to the present invention.The present invention carries out the material and test method arrived used in test general And/or specific description.Although to realize the present invention many materials and operating method used in purpose be it is known in the art that But the present invention is still described in this detail as much as possible.
In following example, when preparing composition, feeds intake every time be no less than 1200g in terms of Radix Astragali if not otherwise specified, Obtained oral solution is dispensed finally with vial, every bottle of 10ml；But when formula is described below, with every preparation The Chinese medicine composition inventory that 100ml takes orally liquid measure indicates.
In the present invention, the manufactured Chinese medicine composition that liquid form is taken in product can be referred to as the red oral solution of blood that；Or Due to including Radix Astragali, Radix Angelicae Sinensis, three kinds of important medicinal materials of donkey-hide gelatin, also referred to as Hai Ruikang board astragalus, angelica ass glue oral liquid.
Embodiment 1: the preparation of astragalus, angelica ass glue oral liquid Chinese medicine composition
Formula: Radix Astragali 12g, Radix Angelicae Sinensis 5g, Rehmannia glutinosa 4g, Radix Codonopsis 4g, donkey-hide gelatin 2g, ferrous gluconate 0.32g, white granulated sugar 100mL is made in 12g, Purified Water q. s.
Preparation method:
(1) Radix Astragali, Radix Angelicae Sinensis, Rehmannia glutinosa, Radix Codonopsis are taken, purified water is added to decoct the secondary (purified waters of first time plus 6 times of amounts decoction 2h, filtering, obtains filtrate；Second of filter residue adds the purified water of 6 times of amounts to decoct 2h, and filtering obtains filtrate), merge filtrate twice；
(2) by combined filtrate, medical fluid and medicinal material weight ratio 1:1 are concentrated under reduced pressure into；95% ethyl alcohol, which is added, makes alcohol content Up to 60%, alcohol precipitation 24 hours are stood, supernatant is taken, filtered, obtain filtrate；
(3) ethyl alcohol is recovered under reduced pressure at a temperature of 70 DEG C in filtrate obtained by step (2), until no alcohol liquid is concentrated under reduced pressure without alcohol taste It is 1.05~1.08 (40 DEG C of temperature of measurement) to relative density, obtains Chinese medicine extract, it is spare；
(4) donkey-hide gelatin is pounded fine grained chippings, adds the purified water heating of 10 times of amounts to make it completely dissolved, filters, it is spare；
(5) ferrous gluconate and flavoring agent are merged, the purified water of 3 times of amounts is added to dissolve by heating, it is spare；
(6) above step (3), (4), (5) each medical fluid are merged, is uniformly mixed, adds purified water constant volume, stir evenly, mistake The Chinese medicine composition of drink form is made in filter, packing, sealing, pressure sterilizing (105 DEG C of sterilizing 45min).
Embodiment 2: the preparation of astragalus, angelica ass glue oral liquid Chinese medicine composition
Formula: Radix Astragali 12g, Radix Angelicae Sinensis 4.5g, Rehmannia glutinosa 4.5g, Radix Codonopsis 3.5g, donkey-hide gelatin 2.5g, ferrous gluconate 0.25g, 100mL is made in white granulated sugar 14g, Purified Water q. s.
Preparation method:
(1) Radix Astragali, Radix Angelicae Sinensis, Rehmannia glutinosa, Radix Codonopsis are taken, purified water is added to decoct the secondary (purified waters of first time plus 5 times of amounts decoction 3h, filtering, obtains filtrate；Second of filter residue adds the purified water of 8 times of amounts to decoct 2h, and filtering obtains filtrate), merge filtrate twice；
(2) by combined filtrate, medical fluid and medicinal material weight ratio 0.8:1 are concentrated under reduced pressure into；98% ethyl alcohol, which is added, makes alcohol-containing Amount stands alcohol precipitation 20 hours, takes supernatant up to 55%, filters, obtains filtrate；
(3) ethyl alcohol is recovered under reduced pressure at a temperature of 80 DEG C in filtrate obtained by step (2), until no alcohol liquid is concentrated under reduced pressure without alcohol taste It is 1.05~1.08 (40 DEG C of temperature of measurement) to relative density, obtains Chinese medicine extract, it is spare；
(4) donkey-hide gelatin is pounded fine grained chippings, adds the purified water heating of 8 times of amounts to make it completely dissolved, filters, it is spare；
(5) ferrous gluconate and flavoring agent are merged, the purified water of 4 times of amounts is added to dissolve by heating, it is spare；
(6) above step (3), (4), (5) each medical fluid are merged, is uniformly mixed, adds purified water constant volume, stir evenly, mistake The Chinese medicine composition of drink form is made in filter, packing, sealing, pressure sterilizing (105 DEG C of sterilizing 45min).
Embodiment 3: the preparation of astragalus, angelica ass glue oral liquid Chinese medicine composition
Formula: Radix Astragali 12g, Radix Angelicae Sinensis 5.5g, Rehmannia glutinosa 3.5g, Radix Codonopsis 4.5g, donkey-hide gelatin 1.5g, ferrous gluconate 0.35g, 100mL is made in white granulated sugar 10g, Purified Water q. s.
Preparation method:
(1) Radix Astragali, Radix Angelicae Sinensis, Rehmannia glutinosa, Radix Codonopsis are taken, purified water is added to decoct the secondary (purified waters of first time plus 8 times of amounts decoction 1h, filtering, obtains filtrate；Second of filter residue adds the purified water of 5 times of amounts to decoct 3h, and filtering obtains filtrate), merge filtrate twice；
(2) by combined filtrate, medical fluid and medicinal material weight ratio 1.2:1 are concentrated under reduced pressure into；95% ethyl alcohol, which is added, makes alcohol-containing Amount stands alcohol precipitation 30 hours, takes supernatant up to 65%, filters, obtains filtrate；
(3) ethyl alcohol is recovered under reduced pressure at a temperature of 60 DEG C in filtrate obtained by step (2), until no alcohol liquid is concentrated under reduced pressure without alcohol taste It is 1.05~1.08 (40 DEG C of temperature of measurement) to relative density, obtains Chinese medicine extract, it is spare；
(4) donkey-hide gelatin is pounded fine grained chippings, adds the purified water heating of 12 times of amounts to make it completely dissolved, filters, it is spare；
(5) ferrous gluconate and flavoring agent are merged, the purified water of 2 times of amounts is added to dissolve by heating, it is spare；
(6) above step (3), (4), (5) each medical fluid are merged, is uniformly mixed, adds purified water constant volume, stir evenly, mistake The Chinese medicine composition of drink form is made in filter, packing, sealing, pressure sterilizing (105 DEG C of sterilizing 45min).
Embodiment 4: the preparation of astragalus, angelica ass glue oral liquid Chinese medicine composition
Formula: Radix Astragali 12g, Radix Angelicae Sinensis 6g, Rehmannia glutinosa 3g, Radix Codonopsis 5g, donkey-hide gelatin 1g, ferrous gluconate 0.2g, white granulated sugar 100mL is made in 16g, Purified Water q. s.
Preparation method:
(1) Radix Astragali, Radix Angelicae Sinensis, Rehmannia glutinosa, Radix Codonopsis are taken, purified water is added to decoct the secondary (purified waters of first time plus 7 times of amounts decoction 2h, filtering, obtains filtrate；Second of filter residue adds the purified water of 7 times of amounts to decoct 1h, and filtering obtains filtrate), merge filtrate twice；
(2) by combined filtrate, medical fluid and medicinal material weight ratio 0.9:1 are concentrated under reduced pressure into；90% ethyl alcohol, which is added, makes alcohol-containing Amount stands alcohol precipitation 25 hours, takes supernatant up to 65%, filters, obtains filtrate；
(3) ethyl alcohol is recovered under reduced pressure at a temperature of 75 DEG C in filtrate obtained by step (2), until no alcohol liquid is concentrated under reduced pressure without alcohol taste It is 1.05~1.08 (40 DEG C of temperature of measurement) to relative density, obtains Chinese medicine extract, it is spare；
(4) donkey-hide gelatin is pounded fine grained chippings, adds the purified water heating of 9 times of amounts to make it completely dissolved, filters, it is spare；
(5) ferrous gluconate and flavoring agent are merged, the purified water of 2.5 times of amounts is added to dissolve by heating, it is spare；
(6) above step (3), (4), (5) each medical fluid are merged, is uniformly mixed, adds purified water constant volume, stir evenly, mistake The Chinese medicine composition of drink form is made in filter, packing, sealing, pressure sterilizing (105 DEG C of sterilizing 45min).
Embodiment 5: the preparation of astragalus, angelica ass glue oral liquid Chinese medicine composition
Formula: Radix Astragali 12g, Radix Angelicae Sinensis 4g, Rehmannia glutinosa 5g, Radix Codonopsis 3g, donkey-hide gelatin 3g, ferrous gluconate 0.4g, white granulated sugar 8g, 100mL is made in Purified Water q. s.
Preparation method:
(1) Radix Astragali, Radix Angelicae Sinensis, Rehmannia glutinosa, Radix Codonopsis are taken, purified water is added to decoct the secondary (purified waters of first time plus 6 times of amounts decoction 2h, filtering, obtains filtrate；Second of filter residue adds the purified water of 5 times of amounts to decoct 2h, and filtering obtains filtrate), merge filtrate twice；
(2) by combined filtrate, medical fluid and medicinal material weight ratio 1.1:1 are concentrated under reduced pressure into；96% ethyl alcohol, which is added, makes alcohol-containing Amount stands alcohol precipitation 28 hours, takes supernatant up to 62%, filters, obtains filtrate；
(3) ethyl alcohol is recovered under reduced pressure at a temperature of 65 DEG C in filtrate obtained by step (2), until no alcohol liquid is concentrated under reduced pressure without alcohol taste It is 1.05~1.08 (40 DEG C of temperature of measurement) to relative density, obtains Chinese medicine extract, it is spare；
(4) donkey-hide gelatin is pounded fine grained chippings, adds the purified water heating of 11 times of amounts to make it completely dissolved, filters, it is spare；
(5) ferrous gluconate and flavoring agent are merged, the purified water of 3.5 times of amounts is added to dissolve by heating, it is spare；
(6) above step (3), (4), (5) each medical fluid are merged, is uniformly mixed, adds purified water constant volume, stir evenly, mistake The Chinese medicine composition of drink form is made in filter, packing, sealing, pressure sterilizing (105 DEG C of sterilizing 45min).
Embodiment 6: the preparation of astragalus, angelica ass glue oral liquid Chinese medicine composition
Formula: Radix Astragali 12g, Radix Angelicae Sinensis 5g, Rehmannia glutinosa 4g, Radix Codonopsis 4g, donkey-hide gelatin 2g, ferrous gluconate 0.32g, white granulated sugar 100mL is made in 12g, Purified Water q. s.
Preparation method:
(1) Radix Astragali, Radix Angelicae Sinensis, Rehmannia glutinosa, Radix Codonopsis are taken, purified water is added to decoct secondary (the purifying decoctings of first time plus 6.5 times of amounts 2.5h is boiled, filters, obtains filtrate；Second of filter residue adds the purified water of 7.5 times of amounts to decoct 1.5, and filtering obtains filtrate), merging is filtered twice Liquid；
(2) by combined filtrate, medical fluid and medicinal material weight ratio 1:1 are concentrated under reduced pressure into；97% ethyl alcohol, which is added, makes alcohol content Up to 60%, alcohol precipitation 26 hours are stood, supernatant is taken, filtered, obtain filtrate；
(3) ethyl alcohol is recovered under reduced pressure at a temperature of 70 DEG C in filtrate obtained by step (2), until no alcohol liquid is concentrated under reduced pressure without alcohol taste It is 1.05~1.08 (40 DEG C of temperature of measurement) to relative density, obtains Chinese medicine extract, it is spare；
(4) donkey-hide gelatin is pounded fine grained chippings, adds the purified water heating of 11 times of amounts to make it completely dissolved, filters, it is spare；
(5) ferrous gluconate and flavoring agent are merged, the purified water of 4 times of amounts is added to dissolve by heating, it is spare；
(6) above step (3), (4), (5) each medical fluid are merged, is uniformly mixed, adds purified water constant volume, stir evenly, mistake The Chinese medicine composition of drink form is made in filter, packing, sealing, pressure sterilizing (105 DEG C of sterilizing 45min).
Embodiment 7: the preparation of astragalus, angelica ass glue oral liquid Chinese medicine composition
Formula: Radix Astragali 12g, Radix Angelicae Sinensis 5g, Rehmannia glutinosa 4g, Radix Codonopsis 4g, donkey-hide gelatin 2g, ferrous gluconate 0.32g, white granulated sugar 100mL is made in 12g, Purified Water q. s.
Preparation method:
(1) Radix Astragali, Radix Angelicae Sinensis, Rehmannia glutinosa, Radix Codonopsis are taken, purified water is added to decoct the secondary (purified waters of first time plus 7 times of amounts decoction 1h, filtering, obtains filtrate；Second of filter residue adds the purified water of 6.5 times of amounts to decoct 1.5h, and filtering obtains filtrate), merge filtrate twice；
(2) by combined filtrate, medical fluid and medicinal material weight ratio 0.9:1 are concentrated under reduced pressure into；98% ethyl alcohol, which is added, makes alcohol-containing Amount stands alcohol precipitation 24 hours, takes supernatant up to 65%, filters, obtains filtrate；
(3) ethyl alcohol is recovered under reduced pressure at a temperature of 75 DEG C in filtrate obtained by step (2), until no alcohol liquid is concentrated under reduced pressure without alcohol taste It is 1.05~1.08 (40 DEG C of temperature of measurement) to relative density, obtains Chinese medicine extract, it is spare；
(4) donkey-hide gelatin is pounded fine grained chippings, adds the purified water heating of 8 times of amounts to make it completely dissolved, filters, it is spare；
(5) ferrous gluconate and flavoring agent are merged, the purified water of 4 times of amounts is added to dissolve by heating, it is spare；
(6) above step (3), (4), (5) each medical fluid are merged, is uniformly mixed, adds purified water constant volume, stir evenly, mistake The Chinese medicine composition of drink form is made in filter, packing, sealing, pressure sterilizing (105 DEG C of sterilizing 45min).
Embodiment 8: the preparation of astragalus, angelica ass glue oral liquid Chinese medicine composition
Formula: Radix Astragali 12g, Radix Angelicae Sinensis 5g, Rehmannia glutinosa 4g, Radix Codonopsis 4g, donkey-hide gelatin 2g, ferrous gluconate 0.32g, white granulated sugar 100mL is made in 12g, Purified Water q. s.
Preparation method:
(1) Radix Astragali, Radix Angelicae Sinensis, Rehmannia glutinosa, Radix Codonopsis are taken, purified water is added to decoct the secondary (purified waters of first time plus 5 times of amounts decoction 3h, filtering, obtains filtrate；Second of filter residue adds the purified water of 6 times of amounts to decoct 2h, and filtering obtains filtrate), merge filtrate twice；
(2) by combined filtrate, medical fluid and medicinal material weight ratio 0.9:1 are concentrated under reduced pressure into；95% ethyl alcohol, which is added, makes alcohol-containing Amount stands alcohol precipitation 20~30 hours, takes supernatant up to 60%, filters, obtains filtrate；
(3) ethyl alcohol is recovered under reduced pressure at a temperature of 76 DEG C in filtrate obtained by step (2), until no alcohol liquid is concentrated under reduced pressure without alcohol taste It is 1.05~1.08 (40 DEG C of temperature of measurement) to relative density, obtains Chinese medicine extract, it is spare；
(4) donkey-hide gelatin is pounded fine grained chippings, adds the purified water heating of 11 times of amounts to make it completely dissolved, filters, it is spare；
(5) ferrous gluconate and flavoring agent are merged, the purified water of 3 times of amounts is added to dissolve by heating, it is spare；
(6) above step (3), (4), (5) each medical fluid are merged, is uniformly mixed, adds purified water constant volume, stir evenly, mistake The Chinese medicine composition of drink form is made in filter, packing, sealing, pressure sterilizing (105 DEG C of sterilizing 45min).
Embodiment 9: the preparation of astragalus, angelica ass glue oral liquid Chinese medicine composition
Formula: Radix Astragali 12g, Radix Angelicae Sinensis 5g, Rehmannia glutinosa 4g, Radix Codonopsis 4g, donkey-hide gelatin 2g, ferrous gluconate 0.32g, white granulated sugar 100mL is made in 12g, Purified Water q. s.
Preparation method:
(1) Radix Astragali, Radix Angelicae Sinensis, Rehmannia glutinosa, Radix Codonopsis are taken, purified water is added to decoct the secondary (purified waters of first time plus 7 times of amounts decoction 2h, filtering, obtains filtrate；Second of filter residue adds the purified water of 8 times of amounts to decoct 1.5h, and filtering obtains filtrate), merge filtrate twice；
(2) by combined filtrate, medical fluid and medicinal material weight ratio 1:1 are concentrated under reduced pressure into；95% ethyl alcohol, which is added, makes alcohol content Up to 60%, alcohol precipitation 20 hours are stood, supernatant is taken, filtered, obtain filtrate；
(3) ethyl alcohol is recovered under reduced pressure at a temperature of 68 DEG C in filtrate obtained by step (2), until no alcohol liquid is concentrated under reduced pressure without alcohol taste It is 1.05~1.08 (40 DEG C of temperature of measurement) to relative density, obtains Chinese medicine extract, it is spare；
(4) donkey-hide gelatin is pounded fine grained chippings, adds the purified water heating of 9 times of amounts to make it completely dissolved, filters, it is spare；
(5) ferrous gluconate and flavoring agent are merged, the purified water of 2 times of amounts is added to dissolve by heating, it is spare；
(6) above step (3), (4), (5) each medical fluid are merged, is uniformly mixed, adds purified water constant volume, stir evenly, mistake The Chinese medicine composition of drink form is made in filter, packing, sealing, pressure sterilizing (105 DEG C of sterilizing 45min).
Embodiment 10: the preparation of astragalus, angelica ass glue oral liquid Chinese medicine composition
The formula and preparation method of 1~embodiment of embodiment 9 are respectively referred to, different is only, also into filtrate obtained by step (2) Add sodium citrate (weight ratio of medicinal material Radix Astragali and sodium citrate is 12:0.1) and the sorbierite (weight of medicinal material Radix Astragali and sorbierite Amount is than being 12:0.5), ethyl alcohol and concentration operation is recovered under reduced pressure followed by step (4) are carried out, obtains 9 batches of oral solutions, respectively according to The secondary sample that can be described as embodiment 101, embodiment 102 ... embodiment 109.
Clinical test example: using 101 two kinds of oral solutions of embodiment 1 and embodiment be respectively used to 120 and 90 anaemias by Excellent effect is also presented in examination person, the effect being completely cured, 211 oral solution of embodiment.Specific test is as follows.It chooses Anemic patients 210 of in March, 2014~2016 year clinical definite in July are used as research object, are classified as example 1 group 120 Example and embodiment 101 groups 90, give embodiment 1 and embodiment 101 oral solution respectively；In addition, also choose in December, 2015~ Anemic patients 107 of the clinical definite of in September, 2018 be used as 211 groups of research objects of embodiment, test method and condition with it is above-mentioned Example 1 group is identical with 101 groups of embodiment, is given embodiment 211 oral solution.The daily mouth of subject in three groups of tests It takes corresponding embodiment oral solution and is equivalent to ferrous gluconate 64mg, give in two times, each subject continuously takes 12 weeks respectively； Example 1 group male to female ratio 51:69, the age 33~54 years old, average (40.43 ± 5.38) year, severity of anemia: slight 24, in Degree 67, severe 29；Embodiment 101 groups of male to female ratio 36:54, the age 38~59 years old, average (42.43 ± 4.64) year, it is poor Blood degree: slight 19, moderate 53, severe 18；211 groups of male to female ratio 42:65 of embodiment, the age 36~52 years old, are averaged (44.14 ± 4.16) year, severity of anemia: slight 27, moderate 55, severe 25；Three groups of ages, gender isobase data ratio Compared with no significant difference (P > 0.05).It observes and compares three groups of curative effects and quality of life condition, including hemoglobin (Hb), Red blood cell (RBC), hematocrit value (HCT) etc., Hb index is divided into: slight > 90g/L, 60~90g/L of moderate, severe < 30g/ L；It is scored using appraisal of life quality table (GQOL-74), including physiological function, social function and mental status etc., total score 100 Point, it is directly proportional to curative effect.Data are analyzed with the statistical software of SPSS 20.0, and measurement data is indicated with " x ± s ", is examined using t It tests；Enumeration data is indicated with number of cases (n), percentage (%), is examined using x2, is that difference is statistically significant with P < 0.05.Three Group subject shows the effect cured completely, and 101 groups of embodiment before relatively treating in terms of the indexs such as Hb, RBC, HCT It is better than example 1 group, but no significant difference (P > 0.05) with 211 groups of improvement degree of embodiment.Concrete outcome is as follows: real Apply 1 group of example of Hb (g/L), RBC (× 1012/ L), be respectively 73.86 ± 4.83,2.71 before three treatment parameters of HCT (%) ± 0.23,22.58 ± 2.55, it is respectively 89.43 ± 3.48,3.32 ± 0.27,32.71 ± 3.82 after treatment；101 groups of embodiment Hb(g/L)、RBC(×1012/ L), be respectively 71.91 ± 6.25,2.67 ± 0.18,21.37 before three treatment parameters of HCT (%) ± 2.32, it is respectively 93.57 ± 4.35,3.38 ± 0.43,33.16 ± 4.36 after treatment；Hb (g/L), the RBC that 211 groups of embodiment (×1012/ L), be respectively 74.14 ± 5.42,2.56 ± 0.26,23.42 ± 3.53, after treatment before three treatment parameters of HCT (%) Respectively 94.83 ± 4.76,3.26 ± 0.17,36.16 ± 4.64.The GQOL-74 Score index of three groups of subjects compares: implementing 1 group of physiological function (76.47 ± 3.85) of example point, social function (79.92 ± 5.24) point, mental status (83.88 ± 4.45) point, 101 groups of physiological functions (79.34 ± 4.25) of embodiment point, social function (84.21 ± 2.77) point, mental status (85.62 ± 5.47) divide, 101 groups of physiological functions (78.63 ± 3.17) of embodiment point, social function (83.87 ± 3.83) point, mental status (87.66 ± 4.04) divide；As it can be seen that 211 groups of GQOL-74 score values of 101 groups of embodiment and embodiment are better than example 1 group, but poor Different not statistically significant (P > 0.05).In addition, (integrated distribution is in example 1 group and embodiment 101 by part subject through counting Group) in reports of taking in the period in 12 weeks there are 4~9 constipation, each group averagely occurs in terms of constipation number (i.e. in 12 weeks by everyone The sum of number of every group of whole subjects reported is divided by quotient obtained by total number of persons), example 1 group has 1.74 times, 101 groups of embodiment Having 1.62 times, 211 groups of embodiment has 0.13 time, under this shows that 211 composition of embodiment above-mentioned adverse reaction probability occurs significantly Drop.
Test example 1: oral solution obtained by various embodiments of the invention, respectively according to one corresponding medicine of " Chinese Pharmacopoeia " version in 2015 The method of material kind measures typical composition content therein, and measurement object includes: that (measurement Astragaloside IV, Mao Ruiyi are yellow for Radix Astragali Ketone glucoside), Rehmannia glutinosa (measurement acteoside), Radix Angelicae Sinensis (measurement ferulic acid), Radix Codonopsis (measure Radix Codonopsis with RP-HPLC method Alkynes glycosides, measuring method: Wang Runsheng etc., the content analysis of lobetyolin in Radix Codonopsis medicinal material, Pharmaceutical Analysis magazine, 2007 08 Phase).
Test example 2: high-temperature treatment test: various embodiments of the invention are prepared into gained oral solution, are placed at 40 DEG C of temperature It places 6 months (can be described as disposition in high temperature June), at 6 months, whether observation/measurement/calculating had sediment generation, and according to examination Test variation of the measurement object content of four classes described in example 1 relative to its 0 month when (is indicated, i.e. content in June phase with percentage contents For the percentage of 0 month content).
After preparation original state the results show that the 9 batches of oral solutions of gained of embodiment 10 distinguish its corresponding embodiment 1~ Four classes measurement object is essentially identical in the initial state for 9 batches of oral solutions of embodiment, has no difference, specifically, embodiment 10 Four class of oral solution measurement object content is 98.3~103.2% models of its corresponding Examples 1 to 9 oral solution respective substance content In enclosing, such as 1 oral solution of embodiment and 101 oral solution of the embodiment indifference in terms of above-mentioned four class measures object content, it is real Apply 99.6~102.3% ranges that 101 oral solution of example, four class measurement object content is 1 oral solution respective substance content of embodiment It is interior, such as 101 oral solution calycosin glucoside content of embodiment is 1 oral solution calycosin glucoside of embodiment The 100.7% of content shows that four classes measurement object contains gained oral solution in the initial state under the conditions of two kinds of formula/preparation methods It measures essentially identical.In addition, 1~10 gained oral solution of the above various embodiments is in clear solution after preparation, sediment is had no.
High-temperature treatment test the results show that when June, in terms of the character of oral solution, 1~embodiment of embodiment 9 is all There are different degrees of sediments for oral solution, are in suspended state after shaking；And all nine kinds of oral solutions are not present embodiment 10 Sediment still maintains clear solution state.
High-temperature treatment is tested in terms of the chemical composition change of oral solution, in addition to calycosin glucoside, different mouths Take content of remaining each measurement object of liquid both with respect at the sample 0 month without significant change, respective three classification of each oral solution Mark content in object June be corresponding 0 month content of oral solution respective objects object 97.2~99.6% ranges, such as Astragaloside IV and Say that 1 oral solution content in June of embodiment is the 98.3% of 0 month content；But different oral solution samples are in calycosin glucose Different variations is presented at June in terms of glycosides, with percentage contents in June (percentage contents when relative to 0 month, i.e. June Concentration is divided by 0 month concentration multiplied by 100% gained percentage) characterization, the whole oral solutions of 1~embodiment of embodiment 9 84~ 88% range, and the whole oral solutions of embodiment 10 are significantly higher than 1~embodiment of embodiment 9, example in 98.2~99.8% ranges If embodiment 1 is 86.3%, embodiment 101 is 98.7%.
Embodiment 21: nine samples of embodiment 10 i.e. embodiment 101, embodiment 102 ... embodiment 109 are respectively referred to Formula and preparation method, different be only sodium citrate therein is replaced with sodium tartrate, sorbierite is replaced with glycine, Medicinal material Radix Astragali: sodium tartrate: the weight ratio of glycine is 12:0.25:0.75, and 9 batches of oral solution samples are made, can successively claim respectively For embodiment 211,219 sample of embodiment 212 ... embodiment.
It is tested according to test example 1 and 2 method of test example, 21 gained oral solution of the present embodiment equal deposit-free when initial.
The 9 batches of oral solutions of gained of embodiment 21 distinguish 9 batches of oral solutions of its corresponding embodiment 10 in the initial state four Class measurement object is essentially identical, has no difference, and specifically, it is its phase that 21 oral solution of embodiment, four class, which measures object content, In 98.8~102.7% ranges for answering 10 oral solution respective substance content of embodiment, such as 211 oral solution of embodiment and embodiment 101 oral solutions indifference, 211 oral solution of embodiment, four class in terms of above-mentioned four class measures object content measure object content It is in 99.2~101.6% ranges of 101 oral solution respective substance content of embodiment, such as 211 oral solution Mao Ruiyi of embodiment Flavones glucoside content is the 99.6% of 101 oral solution calycosin glucoside content of embodiment, shows to match at two kinds Four classes measurement object content is essentially identical in the initial state for gained oral solution under the conditions of side/preparation method.In addition, above embodiments 21 gained oral solutions are in clear solution after preparation, have no sediment.After high-temperature treatment tests June, embodiment 21 whole nine Kind oral solution is showed no sediment, still maintains clear solution state.High-temperature treatment test June after, oral solution chemistry at Divide variation aspect, all respectively four class object contents in June are corresponding oral solution respective objects objects 0 to nine kinds of oral solutions to embodiment 21 98.4~100.2% ranges of month content, such as 211 oral solution content in June of embodiment is 0 month content for Astragaloside IV 99.7%, 212 oral solution content in June of embodiment is the 99.1% of 0 month content for calycosin glucoside, this A bit the result shows that the whole nine kinds of oral solutions of embodiment 21 and the whole nine kinds of similar displays of oral solution of embodiment 10 are equal in all respects Has excellent stability.
Test example 3: filtering and viscosity test
Although embodiment 10 is essentially identical in terms of chemical property is especially its stability with 21 oral solution of embodiment, The inventors discovered that when carrying out final filtration to medical fluid, the medical fluid of different formulations is presented the step of preparing injection in (6) It significantly, may difference related with the component in formula.Specifically, in step (6), it is (poly- using filtering with microporous membrane Tetrafluoroethylene, ￠ 100mm, aperture 0.5um, filter pressure 0.3Mpa) medical fluid is filtered, each prescription is in filtering with mistake The identical parameters that filter is recommended carry out, each filtering liquid medicine amount 10L, to filter the injection of same volume/temperature (26~28 DEG C) The filtration time of water is 1 as contrasting, and opposite filtration time of the oral solution in final filtration, as a result shows in recording step (6) Show, the opposite filtration times of nine oral solutions of embodiment 10 is 2.14~2.27, nine oral solutions of embodiment 21 it is opposite Filtration time is 1.31~1.35, such as embodiment 101 is 2.25 with respect to filtration time, and embodiment 211 is with respect to filtration time 1.32.In addition, measuring embodiment 10 with the viscosity of 21 oral solution of embodiment (relative to water for injection under mutually synthermal (22 DEG C) Relative viscosity), the relative viscosity of nine oral solutions of embodiment 10 is 1.53~1.68, the phase of nine oral solutions of embodiment 21 It is 1.13~1.17 to filtration time, such as embodiment 102 is 1.64 with respect to filtration time, embodiment 212 is with respect to filtration time It is 1.14, it is seen that relevance is presented in medical fluid viscosity and filtering complexity.By this test example result as it can be seen that 21 oral solution of embodiment Has more excellent Technological adaptability.
Embodiment 22: respectively referring to embodiment 21, and different is only to add sodium tartrate in corresponding steps and sweet ammonia is not added Acid, there is different degrees of sediment in gained oral solution result whole oral solution after disposing same high temperature June, after shaking In suspended state, and calycosin glucoside percentage contents in June are in 81~85% ranges；Referring for example to embodiment 211 Recipes are only not add glycine, and gained oral solution calycosin glucoside percentage contents in June are 83.2%.
Embodiment 23: respectively referring to embodiment 21, and different is only to add glycine in corresponding steps and tartaric acid is not added Sodium, there is different degrees of sediment in gained oral solution result whole oral solution after disposing same high temperature June, after shaking In suspended state, and calycosin glucoside percentage contents in June are in 83~85% ranges；Referring for example to embodiment 212 Recipes are only not add sodium tartrate, and gained oral solution calycosin glucoside percentage contents in June are 81.6%.
Embodiment 24: respectively referring to embodiment 21, and different is only that sodium tartrate and glycine are advanceed to step (1) head It is added before secondary decoction, gained oral solution result whole oral solution after disposing same high temperature June has different degrees of sink Starch is in suspended state after shaking, and calycosin glucoside percentage contents in June are in 84~87% ranges；Example As being only to advance to sodium tartrate and glycine to add before step (1) decocts for the first time referring to 213 Recipe of embodiment, gained Oral solution calycosin glucoside percentage contents in June are 84.1%.The result of above embodiments 22~24 is not as it can be seen that Added simultaneously in specific process step oral solution obtained by sodium tartrate and glycine some/defects of some aspects is can not Receive.
Test example 4: improve the effect expedition of energy and blood of human body function delaying human body caducity
As mentioned in this article, the deficiency of vital energy is presented as that movement asthma, movement are nervous, and the deficiency of blood be presented as complexion turn to be yellow, whiten, head Confused nervous, feel not sleep well；And the apparent external embodiment of aging is: poor physical capacity, easily insomnia, Hearing, taste weight, high blood pressure, Alopecia etc..This test 211 gained oral solution of the embodiment of the present invention improves energy and blood of human body function to the present composition and delays people The effect of body aging is investigated.It is included in subject 146 of test, male 53, women 93, the age 38~57 years old, During 1 month before on-test continues, evaluation is combined by observation, inquiry, private prosecution, has the deficiency of vital energy in this 146 subjects Shower is 131 people, has deficiency of blood shower to be 108 people, has aging shower to be 124 people.Subject takes of the invention real daily It applies 211 oral solution of example and is equivalent to ferrous gluconate 64mg, give in two times, each subject continuously takes 12 weeks respectively, medication Remain identical substantially before the diet of period, daily life and medication.After medication, combined by observation, inquiry, private prosecution, synthesis is commented Fixed, the deficiency of vital energy shows unchanged person remaining popularity void performance disappearance (deficiency of vital energy significantly improves rate up to 98.5%), deficiency of blood performance for 2 people Unchanged person is 7 people and the performance of remaining people's deficiency of blood disappears (deficiency of blood significantly improves rate up to 93.5%), the unchanged person of aging performance is 6 People and remaining people's aging performance substantially reduces (Senescence rate up to 95.2%).These the result shows that the present composition have it is excellent The effect of good improvement energy and blood of human body function delaying human body caducity.
Test example 5: the effect expedition of resist oxygen lack
With reference to Chen Zhi cuckoo document (Chen Zhijuan, etc. hiding research of the polo flower extract to mouse resisting oxygen lack, Sichuan is dynamic Object, 2012,31 (1)) it is tested.The grouping of experiment mice randomized, is administered in a manner of stomach-filling by every group 10.It is divided into blank pair According to group, positive controls (Propranolol Hydrochloride), embodiment 211, embodiment 212,101 oral solution group of embodiment.Each group stomach-filling Dosage is as follows: blank control group (0.5%CMC-Na solution, 0.1mL/10g), positive controls (Propranolol Hydrochloride, 0.03g/kg), test group (oral solution is equivalent to ferrous gluconate 10mg/kg).Positive drug and test group are with 0.5% CMC-Na solution is formulated as a certain concentration, with 0.1mL/10g volume gastric infusion, once a day, and successive administration 7d, last dose Resist oxygen lack experiment is carried out after 1h.
Oxygen deficit tolerance experiment: selecting 250mL ground wide-mouth bottle, corrects volume in advance with distilled water, and bottom of bottle is put into 10g sodium Lime is to absorb moisture and carbon dioxide.After last dose 1h, mouse is put into bottle, bottleneck smears vaseline, is tightly tamping Bottle cap causes airtightness anoxic, immediately timing, stops recording the anoxia in mice death by suffocation time for dead indication with breathing.It is sub- Sodium nitrate poisoning survival experiment: after last dose 1h, sodium nitrite (0.1mL/ is injected to mouse peritoneal with 200mg/kg dosage 10g), timing immediately is stopped with breathing as dead indication, and record mouse is poisoned the time-to-live.The experiment of Ischemia Injury in Brain anoxic: After last dose 1h, break end rapidly in mouse ear lower part, immediately timing, stops dehiscing to breathe for dead indication with mouse, record Its time-to-live.All data carry out statistical procedures with SPSS10.0 software, and experimental data is with mean ± standard deviation (x ± s) It indicates, comparison among groups are examined using t, and P < 0.05 is to have statistical difference.
Mouse oxygen deficit tolerance experimental result: compared with blank control group, positive controls, embodiment 211, embodiment 212,101 oral solution group of embodiment can significantly extend the time-to-live under mouse normobaric hypoxia, specifically: blank control group, Positive controls, embodiment 211, embodiment 212,101 oral solution group of embodiment time-to-live (min) be respectively 18.62 ± 1.68,24.76 ± 1.84**, 23.11 ± 2.02**, 22.84 ± 1.42*, 21.06 ± 1.92* (wherein, with blank control group Compare, P < 0.01 * P < 0.05, * *).Mouse sodium nitrite poisoning survival experimental result: compared with blank control group, positive control Group and each embodiment group can significantly extend the time-to-live of mouse under the conditions of sodium nitrite poisoning, specifically: blank control group, Positive controls, embodiment 211, embodiment 212,101 oral solution group of embodiment time-to-live (min) be respectively 19.37 ± 1.75,23.54 ± 1.96**, 23.06 ± 1.84**, 24.11 ± 2.23*, 21.87 ± 1.84* (wherein, with blank control group Compare, P < 0.01 * P < 0.05, * *).Acute cerebral ischemia in mice anoxic experimental result: compared with blank control group, positive control Mouse dehisces the snorting duration after group and each embodiment group can significantly extend broken end, specifically: blank control group, the positive Control group, embodiment 211, embodiment 212,101 oral solution group of embodiment time-to-live (min) be respectively 19.57 ± 2.03, 23.73 ± 1.87**, 23.32 ± 1.94**, 22.96 ± 2.11*, 22.01 ± 2.52* (wherein, compared with blank control group, * P < 0.01 P < 0.05, * *).
It is obvious to a person skilled in the art that invention is not limited to the details of the above exemplary embodiments, Er Qie In the case where without departing substantially from spirit or essential attributes of the invention, the present invention can be realized in other specific forms.Therefore, no matter From the point of view of which point, the present embodiments are to be considered as illustrative and not restrictive, and the scope of the present invention is by appended power Benefit requires rather than above description limits, it is intended that all by what is fallen within the meaning and scope of the equivalent elements of the claims Variation is included within the present invention.

Claims (10)

1. a kind of Chinese medicine composition, by Radix Astragali, Radix Angelicae Sinensis, Rehmannia glutinosa, Radix Codonopsis, donkey-hide gelatin, ferrous gluconate and optional medicine It is made of auxiliary material.
2. Chinese medicine composition according to claim 1, by 1200 parts by weight of Radix Astragali, 400~600 parts by weight of Radix Angelicae Sinensis, Rehmannia glutinosa 300~500 parts by weight, 300~500 parts by weight of Radix Codonopsis, 100~300 parts by weight of donkey-hide gelatin, 20~40 parts by weight of ferrous gluconate And optional pharmaceutic adjuvant is made；Or
It is by 1200 parts by weight of Radix Astragali, 450~550 parts by weight of Radix Angelicae Sinensis, 350~450 parts by weight of Rehmannia glutinosa, 350~450 weight of Radix Codonopsis Amount part, 150~250 parts by weight of donkey-hide gelatin, 25~35 parts by weight of ferrous gluconate and optional pharmaceutic adjuvant are made；Or
It is by 1200 parts by weight of Radix Astragali, 500 parts by weight of Radix Angelicae Sinensis, 400 parts by weight of Rehmannia glutinosa, 400 parts by weight of Radix Codonopsis, 200 weight of donkey-hide gelatin Amount part, 32 parts by weight of ferrous gluconate and optional pharmaceutic adjuvant are made.
3. Chinese medicine composition according to claim 1 is the liquid preparation of drink form.
4. Chinese medicine composition according to claim 1 is the liquid preparation of drink form, prepares what every 100ml was used Milkvetch Root amount is 8~16g；Or
It is the liquid preparation of drink form, and preparing the Milkvetch Root amount that every 100ml is used is 10~14g；Or
It is the liquid preparation of drink form, and preparing the Milkvetch Root amount that every 100ml is used is 12g.
5. Chinese medicine composition according to claim 1, wherein the pharmaceutic adjuvant includes flavoring agent；For example, the flavoring agent It is sweetener, such as aspartame, acesulfame potassium, saccharin sodium, sucrose.
6. Chinese medicine composition according to claim 1 is the liquid preparation of drink form, by the side included the following steps Method is made:
(1) Radix Astragali, Radix Angelicae Sinensis, Rehmannia glutinosa, Radix Codonopsis are taken, adds purified water to decoct secondary (for example, adding 5~8 times of such as 6 times amounts for the first time Purified water decoct 1~3h such as 2h, filtering, obtain filtrate；Second of filter residue adds the purified water of 5~8 times of such as 6 times amounts to decoct 1 ~3h such as 2h, filtering, obtains filtrate), merge filtrate twice；
(2) by combined filtrate, medical fluid and 0.8~1.2:1 of medicinal material weight ratio such as 1:1 are concentrated under reduced pressure into；Addition ethyl alcohol (such as Concentration be more than or equal to 90% or the ethyl alcohol more than or equal to 95%) reach alcohol content (such as to alcohol content up to 55~65% 60%) alcohol precipitation 20~30 hours, are stood, takes supernatant, filters, obtains filtrate；
(3) ethyl alcohol is recovered under reduced pressure at a temperature of 60~80 DEG C in filtrate obtained by step (2), until no alcohol liquid is concentrated under reduced pressure without alcohol taste It is 1.05~1.08 (40 DEG C of temperature of measurement) to relative density, obtains Chinese medicine extract, it is spare；
(4) donkey-hide gelatin is pounded fine grained chippings, adds the purified water heating of such as 10 times amounts of 8~12 times of amounts to make it completely dissolved, filters, it is standby With；
(5) ferrous gluconate and optional flavoring agent (such as sucrose) are merged, adds the purified water of such as 3 times amounts of 2~4 times of amounts It dissolves by heating, it is spare；
(6) above step (3), (4), (5) each medical fluid are merged, is uniformly mixed, adds purified water constant volume, stir evenly, filters, point Dress, sealing, pressure sterilizing (such as 105 DEG C of sterilizing 45min) to get.
7. Chinese medicine composition according to claim 1, wherein the pharmaceutic adjuvant further includes sodium citrate and sorbierite；For example, The weight ratio of medicinal material Radix Astragali and sodium citrate is 12:0.1；For example, the weight ratio of medicinal material Radix Astragali and sorbierite is 12:0.5；Example Such as, sodium citrate and sorbierite are added in the filtrate obtained by step (2).
8. Chinese medicine composition according to claim 1, wherein the pharmaceutic adjuvant further includes sodium tartrate and glycine；For example, The weight ratio of medicinal material Radix Astragali and sodium tartrate is 12:0.25；For example, the weight ratio of medicinal material Radix Astragali and glycine is 12:0.75；Example Such as, sodium tartrate and glycine are added in the filtrate obtained by step (2).
9. the method for preparing any one of claim 1~8 Chinese medicine composition, includes the following steps:
(1) Radix Astragali, Radix Angelicae Sinensis, Rehmannia glutinosa, Radix Codonopsis are taken, adds purified water to decoct secondary (for example, adding 5~8 times of such as 6 times amounts for the first time Purified water decoct 1~3h such as 2h, filtering, obtain filtrate；Second of filter residue adds the purified water of 5~8 times of such as 6 times amounts to decoct 1 ~3h such as 2h, filtering, obtains filtrate), merge filtrate twice；
(2) by combined filtrate, medical fluid and 0.8~1.2:1 of medicinal material weight ratio such as 1:1 are concentrated under reduced pressure into；Addition ethyl alcohol (such as Concentration be more than or equal to 90% or the ethyl alcohol more than or equal to 95%) reach alcohol content (such as to alcohol content up to 55~65% 60%) alcohol precipitation 20~30 hours, are stood, takes supernatant, filters, obtains filtrate；
(3) ethyl alcohol is recovered under reduced pressure at a temperature of 60~80 DEG C in filtrate obtained by step (2), until no alcohol liquid is concentrated under reduced pressure without alcohol taste It is 1.05~1.08 (40 DEG C of temperature of measurement) to relative density, obtains Chinese medicine extract, it is spare；
(4) donkey-hide gelatin is pounded fine grained chippings, adds the purified water heating of such as 10 times amounts of 8~12 times of amounts to make it completely dissolved, filters, it is standby With；
(5) ferrous gluconate and optional flavoring agent (such as sucrose) are merged, adds the purified water of such as 3 times amounts of 2~4 times of amounts It dissolves by heating, it is spare；
(6) above step (3), (4), (5) each medical fluid are merged, is uniformly mixed, adds purified water constant volume, stir evenly, filters, point Dress, sealing, pressure sterilizing (such as 105 DEG C of sterilizing 45min) to get.
10. any one of claim 1~8 Chinese medicine composition delays in preparation for improving energy and blood of human body function and improving resist oxygen lack Purposes in the product of aging.
CN201910214913.6A 2019-03-20 2019-03-20 Improve energy and blood of human body function and improves the Chinese medicine composition that resist oxygen lack delays senescence Withdrawn CN109718305A (en)

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Publication number Priority date Publication date Assignee Title
CN114887030A (en) * 2022-05-30 2022-08-12 中山市美太保健制品有限公司 Donkey-hide gelatin blood-enriching oral liquid and preparation method thereof

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CN107929420A (en) * 2017-11-23 2018-04-20 江西天元药业有限公司 Improve energy and blood of human body function and improve the Chinese medicine composition and detection method of immunity

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Application publication date: 20190507