CN106728640A - It is a kind of to treat the Chinese medicine composition that irregular menstruation promotes pregnancy - Google Patents
It is a kind of to treat the Chinese medicine composition that irregular menstruation promotes pregnancy Download PDFInfo
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- A61K36/185—Magnoliopsida (dicotyledons)
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Abstract
The Chinese medicine composition that irregular menstruation promotes pregnancy is treated the invention discloses a kind of.Theory of the inventor according to the diagnosis and treatment based on an overall analysis of the illness and the patient's condition of the traditional Chinese medical science " treating YANG within YIN, treating YIN within YANG ", dexterously according to the difference of different pharmaceutical yin-yang attribute, break through conventional, scheduled to last with flat, creatively by the cultivated land of yin-nourishing, the dried rhizome of rehmannia, HERBA EPIMEDII of yang-tonifying etc., rhizoma cyperi, the Poria cocos of invigorating the spleen, bighead atractylodes rhizome by liver of relaxing etc. organically combine the opposite medicine of the property of medicine, tonifying yin is not grown and greasy does not hinder life, yang-tonifying it is not hot and without hindering seminal fluid, yin yang complementarity reconciles based on overall negative and positive, it is suitable for infertile patient, no matter its preceded menstural cycle, later stage, priority are irregularly；Or Hypomenorrhea.This Chinese medicine composition is greatly expanded and uses object, and bases oneself upon human body at all, is led to and is adjusted menstruation, auxiliary pregnancy determined curative effect.
Description
Technical field
The invention belongs to field of traditional Chinese, the Chinese medicine group that irregular menstruation promotes pregnancy is treated more particularly, to a kind of
Compound.
Background technology
Infertility is one of gynaecology's common disease, although not entail dangers to patient vitals, but drastically influence the body of patient
Heart health, the problems such as cause goodwill as between spouses, family, or even social concern, modern infertility odds is growing day by day.According to system
The ratio of meter China infertility is about 10%~15%, and the trend for increasing year by year, therefore seeks a kind of effective curative
Thing is very meaningful.
In recent years, also there is greatly progress for the treatment of infertility, from the even artificial reproduction of medicine, operation all to infertile
Disease patient brings new hope.But, these treatments also produce many side effects to women, however traditional tcm therapy with
Patient generally considers, and nursing one's health the body function of women itself makes it recover and become pregnant, and can more allow patient to treat compared with doctor trained in Western medicine
The purpose of health is reached while infertile again.Multiple studies have shown that, for the treatment of infertility, Chinese medicine preparation more has excellent than Western medicine
Gesture, treatment irregular menstruation promotes the Chinese medicine preparation market of pregnancy huge.
Theory of traditional Chinese medical science thinks：The topmost etiology and pathogenesis of infertility are exactly deficiency of kidney-QI, and the liver losing its smoothly moving state, punching appoints qi and blood to lose
Adjust, cause in stasis blocking born of the same parents, two essences can not be harmonious.Kidney is the congenital foundation, and the normal ovulation of woman and menstruation are that can woman receive
Pregnant precondition.Visceral dysfunction causes to take the photograph essence into pregnant.Under the influence of this theory, the Chinese medicine of current pharmaceutical factory production
Menstruation regulating and pregnancy promoting preparation, more based on kidney tonifying (such as：TIAOJING CUYUN WAN, zishenyutai pill, kylin ball, seed pill for curing menoxenia, Womb-warming pregnancy-aiding
Piece etc.).Such Chinese medicine preparation, lacks to the conditioning of the entirety of function, is only applicable to infertility deficiency of spleen and stomach patient (or cloudy
The empty or deficiency of yang), more limited to using object.Existing market still lacks can on the whole balance internal organs negative and positive, lead to and adjust menstruation, reach
The preparation of the treatment by Chinese herbs irregular menstruation progestogenic of progestogenic effect.The present invention does not exactly solve this problem and develops.
The content of the invention
The Chinese medicine composition that irregular menstruation promotes pregnancy is treated it is an object of the invention to provide a kind of.
The technical solution used in the present invention is：
A kind of to treat the Chinese medicine composition that irregular menstruation promotes pregnancy, the bulk drug of its active component is cultivated land, the dried rhizome of rehmannia, red
Chinese herbaceous peony, Radix Angelicae Sinensis, Poria cocos, Ligusticum wallichii, Radix Codonopsis, astragali, the bighead atractylodes rhizome, saline cistanche, Morinda officinalis, barrenwort, donkey-hide gelatin, rhizoma cyperi, motherwort, Radix Glycyrrhizae.
The raw material medicaments in part by weight is calculated as：2~10 parts of cultivated land, 2~10 parts of the dried rhizome of rehmannia, 1~8 part of the radix paeoniae rubrathe, 2~9 parts of Radix Angelicae Sinensis,
2~8 parts of Poria cocos, 1~7 part of Ligusticum wallichii, 2~9 parts of Radix Codonopsis, 2~8 parts of astragali, 2~8 parts of the bighead atractylodes rhizome, 2~9 parts of saline cistanche, Morinda officinalis 1~
7 parts, 1~7 part of barrenwort, 1~7 part of donkey-hide gelatin, 2~8 parts of rhizoma cyperi, 2~8 parts of motherwort, 1~5 part of Radix Glycyrrhizae.
Preferably, the raw material medicaments in part by weight is calculated as：3~7 parts of cultivated land, 3~7 parts of the dried rhizome of rehmannia, 2~5 parts of the radix paeoniae rubrathe, Radix Angelicae Sinensis 3
~6 parts, 4~7 parts of Poria cocos, 2~5 parts of Ligusticum wallichii, 3~7 parts of Radix Codonopsis, 3~6 parts of astragali, 3~6 parts of the bighead atractylodes rhizome, 3~7 parts of saline cistanche, bar
2~5 parts of halberd day, 2~5 parts of barrenwort, 2~5 parts of donkey-hide gelatin, 3~6 parts of rhizoma cyperi, 3~6 parts of motherwort, 1~4 part of Radix Glycyrrhizae.
It is further preferred that the raw material medicaments in part by weight is calculated as：5 parts of cultivated land, 5 parts of the dried rhizome of rehmannia, 4 parts of the radix paeoniae rubrathe, 5 parts of Radix Angelicae Sinensis,
5 parts of Poria cocos, 3 parts of Ligusticum wallichii, 5 parts of Radix Codonopsis, 5 parts of astragali, 4 parts of the bighead atractylodes rhizome, 5 parts of saline cistanche, 4 parts of Morinda officinalis, 4 parts of barrenwort, donkey-hide gelatin 3
Part, 4 parts of rhizoma cyperi, 5 parts of motherwort, 2 parts of Radix Glycyrrhizae.
It is further preferred that the raw material medicaments in part by weight is calculated as：6 parts of cultivated land, 4 parts of the dried rhizome of rehmannia, 3 parts of the radix paeoniae rubrathe, 5 parts of Radix Angelicae Sinensis,
6 parts of Poria cocos, 4 parts of Ligusticum wallichii, 4 parts of Radix Codonopsis, 4 parts of astragali, 5 parts of the bighead atractylodes rhizome, 6 parts of saline cistanche, 4 parts of Morinda officinalis, 3 parts of barrenwort, donkey-hide gelatin 3
Part, 5 parts of rhizoma cyperi, 4 parts of motherwort, 2 parts of Radix Glycyrrhizae.
It is further preferred that the raw material medicaments in part by weight is calculated as：4 parts of cultivated land, 6 parts of the dried rhizome of rehmannia, 4 parts of the radix paeoniae rubrathe, 4 parts of Radix Angelicae Sinensis,
5 parts of Poria cocos, 4 parts of Ligusticum wallichii, 6 parts of Radix Codonopsis, 4 parts of astragali, 5 parts of the bighead atractylodes rhizome, 6 parts of saline cistanche, 3 parts of Morinda officinalis, 4 parts of barrenwort, donkey-hide gelatin 4
Part, 4 parts of rhizoma cyperi, 5 parts of motherwort, 3 parts of Radix Glycyrrhizae.
Rhizoma cyperi described in above bulk drug is prepared RHIZOMA CYPERI with vinegar.
Wherein, the active component is the water extract of bulk drug.
The formulation of Chinese medicine composition is electuary, powder, tablet, pill, paste, oral liquid, capsule, soft capsule or decoction.
The above formulation can be by adding one or more in adhesive, filler, emulsifying agent, solubilizer, sweetener
It is made.
The beneficial effects of the invention are as follows：
Inventor according to the theory of the diagnosis and treatment based on an overall analysis of the illness and the patient's condition of the traditional Chinese medical science " treating YANG within YIN, treating YIN within YANG ", dexterously according to different pharmaceutical
The difference of yin-yang attribute, breaks through routine, is scheduled to last with flat, and creatively by the cultivated land of yin-nourishing, the dried rhizome of rehmannia, HERBA EPIMEDII of yang-tonifying etc. leads to
Crossing rhizoma cyperi, the Poria cocos of invigorating the spleen, bighead atractylodes rhizome etc. of liver of relaxing organically combines the opposite medicine of the property of medicine, tonifying yin do not grow it is greasy do not hinder life, mend
Sun it is not hot and without hindering seminal fluid, yin yang complementarity reconciles based on overall negative and positive, is suitable for infertile patient, no matter its menstruation elder generation
Phase, later stage, priority are irregularly；Or Hypomenorrhea.This Chinese medicine composition is greatly expanded and uses object, and bases oneself upon people
Body is basic, leads to and adjusts menstruation, auxiliary pregnancy determined curative effect.
Specific embodiment
A kind of to treat the Chinese medicine composition that irregular menstruation promotes pregnancy, the bulk drug of its active component is cultivated land, the dried rhizome of rehmannia, red
Chinese herbaceous peony, Radix Angelicae Sinensis, Poria cocos, Ligusticum wallichii, Radix Codonopsis, astragali, the bighead atractylodes rhizome, saline cistanche, Morinda officinalis, barrenwort, donkey-hide gelatin, rhizoma cyperi, motherwort, Radix Glycyrrhizae.
The present invention provides three kinds of preferred composition material medicine compositions：
A kind of to treat the Chinese medicine composition that irregular menstruation promotes pregnancy, the raw material medicaments in part by weight is calculated as：5 parts of cultivated land,
5 parts of the dried rhizome of rehmannia, 4 parts of the radix paeoniae rubrathe, 5 parts of Radix Angelicae Sinensis, 5 parts of Poria cocos, 3 parts of Ligusticum wallichii, 5 parts of Radix Codonopsis, 5 parts of astragali, 4 parts of the bighead atractylodes rhizome, 5 parts of saline cistanche, bar
4 parts of halberd day, 4 parts of barrenwort, 3 parts of donkey-hide gelatin, 4 parts of rhizoma cyperi, 5 parts of motherwort, 2 parts of Radix Glycyrrhizae.
A kind of to treat the Chinese medicine composition that irregular menstruation promotes pregnancy, the raw material medicaments in part by weight is calculated as：6 parts of cultivated land,
4 parts of the dried rhizome of rehmannia, 3 parts of the radix paeoniae rubrathe, 5 parts of Radix Angelicae Sinensis, 6 parts of Poria cocos, 4 parts of Ligusticum wallichii, 4 parts of Radix Codonopsis, 4 parts of astragali, 5 parts of the bighead atractylodes rhizome, 6 parts of saline cistanche, bar
4 parts of halberd day, 3 parts of barrenwort, 3 parts of donkey-hide gelatin, 5 parts of rhizoma cyperi, 4 parts of motherwort, 2 parts of Radix Glycyrrhizae.
A kind of to treat the Chinese medicine composition that irregular menstruation promotes pregnancy, the raw material medicaments in part by weight is calculated as：4 parts of cultivated land,
6 parts of the dried rhizome of rehmannia, 4 parts of the radix paeoniae rubrathe, 4 parts of Radix Angelicae Sinensis, 5 parts of Poria cocos, 4 parts of Ligusticum wallichii, 6 parts of Radix Codonopsis, 4 parts of astragali, 5 parts of the bighead atractylodes rhizome, 6 parts of saline cistanche, bar
3 parts of halberd day, 4 parts of barrenwort, 4 parts of donkey-hide gelatin, 4 parts of rhizoma cyperi, 5 parts of motherwort, 3 parts of Radix Glycyrrhizae.
Fang Zhong, raw cultivated land, Morinda officinalis, barrenwort, saline cistanche are monarch, Radix Angelicae Sinensis, the radix paeoniae rubrathe, donkey-hide gelatin, Ligusticum wallichii, are minister, rhizoma cyperi, benefit
Brittle Falsepimpernel Herb, Radix Glycyrrhizae make for assistant.Raw cultivated land supports kidney yin；Morinda officinalis, barrenwort, saline cistanche support kidney yang；Radix Angelicae Sinensis, the radix paeoniae rubrathe, donkey-hide gelatin, Ligusticum wallichii,
Motherwort benefiting blood and regulating blood circulation；Poria cocos, Radix Codonopsis, astragali, bighead atractylodes rhizome invigorating the spleen tonifying Qi, rhizoma cyperi liver-smoothing, qi-regulating；Radix Glycyrrhizae coordinating the drug actions of a prescription plays flat benefit altogether
The work(of negative and positive, QI invigorating and blood.
There is bulk drug as follows in Traditional Chinese medicine composition formula：
Cultivated land：Sweet, tepor.Enrich blood enriching yin, beneficial to spirit and marrow is the Preparation process product of radix rehmanniae recen.
The dried rhizome of rehmannia：It is sweet, bitter, cool.Clearing heat and promoting fluid enriching yin, blood-nourishing.This product is the fresh or dried root of scrophulariaceae rehmannia glutinosa plant.
The radix paeoniae rubrathe：Bitter, cold nature.Clearing heat and cooling blood, blood stasis removing analgesic.This product is the dry of ranunculaceae plant Chinese herbaceous peony or the river radix paeoniae rubrathe
Dry.
Radix Angelicae Sinensis：Sweet, pungent, temperature.Enrich blood；Promoting blood circulation；Menstruction regulating and pain relieving；Moisturize laxation.This product is the drying of umbelliferae angelica
Root.
Poria cocos：It is sweet, light, it is mild-natured.Clearing damp and promoting diuresis, invigorating the spleen, calming heart.It is the dry sclerotia of On Polyporaceae Poria cocos.
Ligusticum wallichii：It is pungent, temperature.Promote breath and open depression, method wind-dryness is wet, promoting blood circulation and stopping pain.This product is the dry rhizome of samphire Ligusticum wallichii.
Radix Codonopsis：It is sweet, put down.Tonifying middle-Jiao and Qi, clearing heat and detoxicating, expelling phlegm and arresting coughing.This product is Campanulaceae Radix Codonopsis, codonopsis pilosula var. modesta
(RADIX CODONOPSIS PILOSULAE from Northwest of China) or the dry root of radix codonpsis tangshen.
Astragali：It is sweet, temperature, invigorating qi for strengthening superficies, diuretic and maintain drug, apocenosis, expelling pus and promoting granulation is that legume astragalus mongolicus or film pod are yellow
The dry root of stilbene.
The bighead atractylodes rhizome：Bitter, sweet, temperature, strengthening the spleen and replenishing qi, eliminate dampness and have diuretic effect, hidroschesis is antiabortive, is the dry rhizome of the feverfew bighead atractylodes rhizome.
Saline cistanche：It is sweet；It is salty；It is warm in nature.Kidney-replenishing；Benefiting essence-blood；Ease constipation road.This product is the drying of orobanchaceae plant cistanche
Fleshy stem with scale leaf.
Morinda officinalis：It is sweet, pungent, tepor.Kidney-replenishing, strengthening the bones and muscles, wind-damp dispelling.This product is the dry root of madder wort Morinda offcinalis How.
Whole year can excavate, and clean, and remove fibrous root, shine to six, seventy percent dry, gently beat flat, dry.
Barrenwort：Taste is pungent, sweet, warm in nature, kidney-replenishing, strengthening the bones and muscles, wind-damp dispelling.This product is Berberidaceae plant barrenwort, arrow leaf
The dry aerial parts of barrenwort, E. Pubescens, E. wushanense T. S. Ying or korean epimedium herb.
Donkey-hide gelatin：It is sweet, put down.Enrich blood enriching yin, moisturize, stop blooding.This product is the skin of equine species donkey through consolidating that decoction, concentration are made
Body glue.
Rhizoma cyperi：Pungent, slight bitter, micro-sweet, put down.Promoting qi circulation and removing obstruction in the collateral, menstruction regulating and pain relieving.This product is the dry root of sedge nutgrass flatsedge
Stem.
Motherwort：It is bitter, pungent, it is slightly cold.Promoting blood circulation for regulating menstruation, inducing diuresis to remove edema.This product is fresh or dry for labiate motherwort
Dry aerial part
Radix Glycyrrhizae：It is sweet, put down, invigorate the spleen and benefit qi, clearing heat and detoxicating, expelling phlegm and arresting coughing, relieving spasm to stop pain, coordinating the drug actions of a prescription is sweet legume
Drying for grass, swollen fruit Radix or glycyrrhiza glabra is reported and rhizome.
The active component of above-mentioned Chinese medicine composition is water extract, or alcohol extract, fat extract of bulk drug etc., is extracted
Mode is not limited only to this.
The formulation of above-mentioned Chinese medicine composition can for electuary, powder, tablet, pill, paste, oral liquid, capsule, soft capsule or
Decoction.
During the formulation of above-mentioned Chinese medicine composition can be by adding adhesive, filler, emulsifying agent, solubilizer, sweetener
It is made for one or more.
Chinese medicine composition of the invention is applied to：1st, irregular menstruation；2nd, infertility.
Chinese medicine composition of the invention will not cause obvious abnormal response and naked eyes pathological change without acute toxic and side effect,
Suitable for oral conditioning, disable in table card.
With reference to instantiation, the present invention is further illustrated, protection scope of the present invention is not limited only to this.
Embodiment 1, electuary of the present invention and its preparation
Treatment irregular menstruation promotes the instant particles as Chinese medicine of pregnancy, and preparation method is as follows：
1) 3 parts of donkey-hide gelatin is taken, molten is stirred evenly standby；
2) take 5 parts of cultivated land, 5 parts of the dried rhizome of rehmannia, 4 parts of the radix paeoniae rubrathe, 5 parts of Radix Angelicae Sinensis, 5 parts of Poria cocos, 3 parts of Ligusticum wallichii, 5 parts of Radix Codonopsis, 5 parts of astragali,
4 parts of the bighead atractylodes rhizome, 5 parts of saline cistanche, 4 parts of Morinda officinalis, 4 parts of barrenwort, 4 parts of prepared RHIZOMA CYPERI with vinegar, 5 parts of motherwort, 2 parts of Radix Glycyrrhizae, crush, and mix afterwards
Uniformly, soak, decoct 1h, filtering, obtain filtrate, be condensed into Chinese medical concrete, it is standby；
3) take molten donkey-hide gelatin, add beta-schardinger dextrin embedding, be then well mixed with Chinese medical concrete, add soluble starch,
Granulation, drying, sieving, packing obtain product.
Embodiment 2, powder of the present invention and its preparation
Treatment irregular menstruation promotes the traditional Chinese powder medicine of pregnancy, and preparation method is as follows：
1) Chinese medicine is taken by weight：6 parts of cultivated land, 4 parts of the dried rhizome of rehmannia, 3 parts of the radix paeoniae rubrathe, 5 parts of Radix Angelicae Sinensis, 6 parts of Poria cocos, 4 parts of Ligusticum wallichii,
4 parts of Radix Codonopsis, 4 parts of astragali, 5 parts of the bighead atractylodes rhizome, 6 parts of saline cistanche, 4 parts of Morinda officinalis, 3 parts of barrenwort, 3 parts of donkey-hide gelatin, 5 parts of prepared RHIZOMA CYPERI with vinegar, benefit are female
Careless 4 parts, 2 parts of Radix Glycyrrhizae
2) above-mentioned Chinese medicine dried, crushed, well mixed, packing is obtained final product.
Embodiment 3, Tablets and its preparation
Treatment irregular menstruation promotes the Chinese medicinal tablet of pregnancy, and preparation method is as follows：
1) 3 parts of donkey-hide gelatin is taken, molten is stirred evenly standby；
2) take 6 parts of cultivated land, 4 parts of the dried rhizome of rehmannia, 3 parts of the radix paeoniae rubrathe, 5 parts of Radix Angelicae Sinensis, 6 parts of Poria cocos, 4 parts of Ligusticum wallichii, 4 parts of Radix Codonopsis, 4 parts of astragali,
5 parts of the bighead atractylodes rhizome, 6 parts of saline cistanche, 4 parts of Morinda officinalis, 3 parts of barrenwort, 5 parts of prepared RHIZOMA CYPERI with vinegar, 4 parts of motherwort, 2 parts of Radix Glycyrrhizae, crush, and mixing is equal
It is even, soak, decoct 1h, filtering, filtrate is obtained, Chinese medical concrete is condensed into, it is standby；
3) molten donkey-hide gelatin is taken, beta-schardinger dextrin embedding is added, is then well mixed with Chinese medical concrete, add starch, granulation, pressure
Piece is obtained final product.
Embodiment 4, pill of the present invention and its preparation
Treatment irregular menstruation promotes the medicine pill of pregnancy, and preparation method is as follows：
1) 4 parts of donkey-hide gelatin is taken, molten is stirred evenly standby；
2) take 4 parts of cultivated land, 6 parts of the dried rhizome of rehmannia, 4 parts of the radix paeoniae rubrathe, 4 parts of Radix Angelicae Sinensis, 5 parts of Poria cocos, 4 parts of Ligusticum wallichii, 6 parts of Radix Codonopsis, 4 parts of astragali,
5 parts of the bighead atractylodes rhizome, 6 parts of saline cistanche, 3 parts of Morinda officinalis, 4 parts of barrenwort, 4 parts of prepared RHIZOMA CYPERI with vinegar, 5 parts of motherwort, 3 parts of Radix Glycyrrhizae, crush, and mixing is equal
It is even, soak, decoct 1h, filtering, filtrate is obtained, Chinese medical concrete is condensed into, it is standby；
3) molten donkey-hide gelatin is taken, beta-schardinger dextrin embedding is added, is well mixed；Chinese medical concrete, starch and honey are added, is made
Bar, pelletization, packaging is obtained final product.
Embodiment 5, oral liquid of the present invention and its preparation
Treatment irregular menstruation promotes the oral liquid of pregnancy, and step is as follows：
1) 4 parts of moltens of donkey-hide gelatin are taken, is stirred evenly standby；
2) take 4 parts of cultivated land, 6 parts of the dried rhizome of rehmannia, 4 parts of the radix paeoniae rubrathe, 4 parts of Radix Angelicae Sinensis, 5 parts of Poria cocos, 4 parts of Ligusticum wallichii, 6 parts of Radix Codonopsis, 4 parts of astragali,
5 parts of the bighead atractylodes rhizome, 6 parts of saline cistanche, 3 parts of Morinda officinalis, 4 parts of barrenwort, 4 parts of prepared RHIZOMA CYPERI with vinegar, 5 parts of motherwort, 3 parts of Radix Glycyrrhizae, crush, and mixing is equal
It is even, soak, decoct 1h, filtering, filtrate is obtained, Chinese medical concrete is condensed into, it is standby；
3) take molten donkey-hide gelatin to be mixed with Chinese medical concrete, add solubilizer HP-β-CD and water, bottle, seal, go out
Bacterium, packaging are obtained final product.
Embodiment 6, paste of the present invention and its preparation
Treatment irregular menstruation promotes the paste of pregnancy, and step is as follows：
1) by 6 parts of cultivated land, 4 parts of the dried rhizome of rehmannia, 3 parts of the radix paeoniae rubrathe, 5 parts of Radix Angelicae Sinensis, 6 parts of Poria cocos, 4 parts of Ligusticum wallichii, 4 parts of Radix Codonopsis, 4 parts of astragali,
5 parts of the bighead atractylodes rhizome, 6 parts of saline cistanche, 4 parts of Morinda officinalis, 3 parts of barrenwort, 5 parts of prepared RHIZOMA CYPERI with vinegar, 4 parts of motherwort, 2 parts of Radix Glycyrrhizae, crush, and mixing is equal
It is even, soak, decoct 1h, filtering, obtain filtrate；
2) 3 parts of moltens of donkey-hide gelatin are taken in above-mentioned middle drug filtrate, Chinese medicinal ointment is condensed into.
Embodiment 7, capsule of the present invention and its preparation
Treatment irregular menstruation promotes the capsule of pregnancy, and step is as follows：
1) 3 parts of donkey-hide gelatin is taken, molten is stirred evenly standby；
2) take 6 parts of cultivated land, 4 parts of the dried rhizome of rehmannia, 3 parts of the radix paeoniae rubrathe, 5 parts of Radix Angelicae Sinensis, 6 parts of Poria cocos, 4 parts of Ligusticum wallichii, 4 parts of Radix Codonopsis, 4 parts of astragali,
5 parts of the bighead atractylodes rhizome, 6 parts of saline cistanche, 4 parts of Morinda officinalis, 3 parts of barrenwort, 5 parts of prepared RHIZOMA CYPERI with vinegar, 4 parts of motherwort, 2 parts of Radix Glycyrrhizae, crush, and mixing is equal
It is even, soak, decoct 1h, filtering, filtrate is obtained, Chinese medical concrete is condensed into, it is standby；
3) molten donkey-hide gelatin is taken, is embedded with beta-schardinger dextrin, be then well mixed with Chinese medical concrete and starch, filled after low temperature drying
Enter in capsule, packaging is obtained final product.
Embodiment 8, soft capsule of the present invention and preparation method thereof
Treatment irregular menstruation promotes the soft capsule of pregnancy, and step is as follows：
1) 3 parts of donkey-hide gelatin is taken, molten is stirred evenly standby；
2) by 5 parts of cultivated land, 5 parts of the dried rhizome of rehmannia, 4 parts of the radix paeoniae rubrathe, 5 parts of Radix Angelicae Sinensis, 5 parts of Poria cocos, 3 parts of Ligusticum wallichii, 5 parts of Radix Codonopsis, 5 parts of astragali,
4 parts of the bighead atractylodes rhizome, 5 parts of saline cistanche, 4 parts of Morinda officinalis, 4 parts of barrenwort, 4 parts of prepared RHIZOMA CYPERI with vinegar, 5 parts of motherwort, 2 parts of Radix Glycyrrhizae, crush, and mixing is equal
It is even, soak, decoct 1h, filtering, filtrate is obtained, Chinese medical concrete is condensed into, it is standby；
3) Chinese medical concrete colloid mill is further crushed, emulsifying agent then with molten donkey-hide gelatin and routine, diluent
It is well mixed to form liquid, liquid is injected by the production technology of soft capsule, dry, packaging is obtained final product.
Embodiment 9, decoction of the present invention and preparation method thereof
Treatment irregular menstruation promotes the decoction of pregnancy, and step is as follows：
1) by 5 parts of cultivated land, 5 parts of the dried rhizome of rehmannia, 4 parts of the radix paeoniae rubrathe, 5 parts of Radix Angelicae Sinensis, 5 parts of Poria cocos, 3 parts of Ligusticum wallichii, 5 parts of Radix Codonopsis, 5 parts of astragali,
4 parts of the bighead atractylodes rhizome, 5 parts of saline cistanche, 4 parts of Morinda officinalis, 4 parts of barrenwort, 4 parts of prepared RHIZOMA CYPERI with vinegar, 5 parts of motherwort, 2 parts of Radix Glycyrrhizae, are well mixed, plus
Water immersion, decoction 1h, filtering, obtain filtrate；
2) 3 parts of donkey-hide gelatin is taken in molten in drug filtrate, and packaging is obtained final product after cooling.
Curative effect example 1
57 irregular menstruation infertile patients are treated using decoction oral in embodiment 9.The course of disease average out to of patient 3.7 years,
Wherein, polycystic ovary has 12 to account for 21.1%；Tubal factor with fallopian tube obstruction it is smooth based on, there are 15 to account for 26.3%；Uterus
Factor has 4 based on fibroid, immune factor with ACA ACLAs are positive and blocking antibody feminine gender factor based on,
Respectively there are 3.In addition, once doing artificial reproduction has 9, history of operation has 7, and abortion history has 11.
Therapy：Decoction (often wraps 100g, containing crude drug 100g), adult, and orally, daily 2 times, January is 1 course for the treatment of.
Curative effect：After average medication 1 year, all patients recover normal menstrual cycle, successful pregnancies.
Curative effect example 2
Decoction oral treatment Sterility patient 32 is treatment group in using embodiment 9, using melbine (conventional therapy
The Western medicine of infertility) oral medication Sterility patient 30 is control group.Clinical efficacy, serum are observed after 3 menstrual cycles female
Glycol, progestational hormone, ovarian follicle maximum gauge situation, endometrium thickness indices.
Therapy：Treatment group is decoction (100g often being wrapped, containing crude drug 100g), is grown up, and orally, daily 2 times, January is 1 course for the treatment of.
Control group is metformin hydrochloride tablet (500mg), is grown up, and orally, three times a day, January is 1 course for the treatment of.
Curative effect：After 3 months, treatment group fully recovers 24, takes a turn for the better 4, invalid 4, total effective rate 87.5%.
The curative effect situation of the Chinese medicine composition of the present invention of table 1
As shown in table 1, either treatment group or control group, serum estradiol, progestational hormone, ovarian follicle maximum gauge situation,
The curative effect index such as endometrium thickness relatively treat before improve significantly, with significant significant difference (aRepresent and treatment
Preceding comparing, P<0.05)；Additionally, Chinese medicine composition (treatment group) of the invention is improving serum estradiol, progestational hormone, ovarian follicle most
Conventional western medicine treatment (control group) is superior on the curative effect index such as major diameter situation, endometrium thickness, with significant statistics
Difference (bExpression is compared with control group, P<0.05).It can be seen that, Chinese medicine composition of the invention can be effectively improved infertility, and
Curative effect is better than conventional western medicine.
Toxicity test example
Acute toxicity or maximal tolerance dose are carried out using decoction in embodiment 9 to test, Cmax, most is given in preliminary experiment
Large capacity one-time gavage, observation mouse outward appearance, behavioral activity, breathing, secretion, excreta, death etc., continuous 7 days, observation
Period has no dead mouse, it is impossible to measure median lethal dose, can only do maximum administration experiment.SPF grades is taken in maximum administration experiment
Mouse (female) 40, is randomly divided into Chinese medicine group and control group, and Chinese medicine group concentrates 20 times of concentration, 0.8mL/20g with the decoction of example 9
The maximum allowable capacity of volume, maximum can fill concentration and disposably be gavaged through stomach, maximum gavage volume (milliliter)=(the weight of animals (g)
×0.4)/10.Blank control group gives isometric(al) distilled water.Administration the same day, close observation mouse outward appearance, behavioral activity, breathing,
The symptom of secretion, excreta, death and toxic reaction, the order of severity, initial time, the duration, whether it is reversible situations such as.
After administration 8 days, body weight no difference of science of statistics before and after measuring two groups.The gross necropsy heart, liver, spleen, lung, kidney, stomach and intestine etc.
Main organs tissue shows no obvious abnormalities.Using maximum tested concentration, maximum tested volume gastric infusion, LD50More than 35g/kg.
More than 90 times of maximal tolerance dose equivalent to clinical medicine dose.Experiment show example 9 in decoction without acute toxic and side effect.
Claims (10)
1. a kind of to treat the Chinese medicine composition that irregular menstruation promotes pregnancy, the bulk drug of its active component is cultivated land, the dried rhizome of rehmannia, red
Chinese herbaceous peony, Radix Angelicae Sinensis, Poria cocos, Ligusticum wallichii, Radix Codonopsis, astragali, the bighead atractylodes rhizome, saline cistanche, Morinda officinalis, barrenwort, donkey-hide gelatin, rhizoma cyperi, motherwort, Radix Glycyrrhizae.
2. it is according to claim 1 it is a kind of treat irregular menstruation promote pregnancy Chinese medicine composition, it is characterised in that：It is described
Raw material medicaments in part by weight is calculated as：2~10 parts of cultivated land, 2~10 parts of the dried rhizome of rehmannia, 1~8 part of the radix paeoniae rubrathe, 2~9 parts of Radix Angelicae Sinensis, 2~8 parts of Poria cocos,
1~7 part of Ligusticum wallichii, 2~9 parts of Radix Codonopsis, 2~8 parts of astragali, 2~8 parts of the bighead atractylodes rhizome, 2~9 parts of saline cistanche, 1~7 part of Morinda officinalis, barrenwort 1
~7 parts, 1~7 part of donkey-hide gelatin, 2~8 parts of rhizoma cyperi, 2~8 parts of motherwort, 1~5 part of Radix Glycyrrhizae.
3. it is according to claim 1 it is a kind of treat irregular menstruation promote pregnancy Chinese medicine composition, it is characterised in that：It is described
Raw material medicaments in part by weight is calculated as：3~7 parts of cultivated land, 3~7 parts of the dried rhizome of rehmannia, 2~5 parts of the radix paeoniae rubrathe, 3~6 parts of Radix Angelicae Sinensis, 4~7 parts of Poria cocos, river
2~5 parts of rhizome of chuanxiong, 3~7 parts of Radix Codonopsis, 3~6 parts of astragali, 3~6 parts of the bighead atractylodes rhizome, 3~7 parts of saline cistanche, 2~5 parts of Morinda officinalis, barrenwort 2~
5 parts, 2~5 parts of donkey-hide gelatin, 3~6 parts of rhizoma cyperi, 3~6 parts of motherwort, 1~4 part of Radix Glycyrrhizae.
4. it is according to claim 1 it is a kind of treat irregular menstruation promote pregnancy Chinese medicine composition, it is characterised in that：It is described
Raw material medicaments in part by weight is calculated as：5 parts of cultivated land, 5 parts of the dried rhizome of rehmannia, 4 parts of the radix paeoniae rubrathe, 5 parts of Radix Angelicae Sinensis, 5 parts of Poria cocos, 3 parts of Ligusticum wallichii, 5 parts of Radix Codonopsis, north
5 parts of stilbene, 4 parts of the bighead atractylodes rhizome, 5 parts of saline cistanche, 4 parts of Morinda officinalis, 4 parts of barrenwort, 3 parts of donkey-hide gelatin, 4 parts of rhizoma cyperi, 5 parts of motherwort, Radix Glycyrrhizae 2
Part.
5. it is according to claim 1 it is a kind of treat irregular menstruation promote pregnancy Chinese medicine composition, it is characterised in that：It is described
Raw material medicaments in part by weight is calculated as：6 parts of cultivated land, 4 parts of the dried rhizome of rehmannia, 3 parts of the radix paeoniae rubrathe, 5 parts of Radix Angelicae Sinensis, 6 parts of Poria cocos, 4 parts of Ligusticum wallichii, 4 parts of Radix Codonopsis, north
4 parts of stilbene, 5 parts of the bighead atractylodes rhizome, 6 parts of saline cistanche, 4 parts of Morinda officinalis, 3 parts of barrenwort, 3 parts of donkey-hide gelatin, 5 parts of rhizoma cyperi, 4 parts of motherwort, Radix Glycyrrhizae 2
Part.
6. it is according to claim 1 it is a kind of treat irregular menstruation promote pregnancy Chinese medicine composition, it is characterised in that：It is described
Raw material medicaments in part by weight is calculated as：4 parts of cultivated land, 6 parts of the dried rhizome of rehmannia, 4 parts of the radix paeoniae rubrathe, 4 parts of Radix Angelicae Sinensis, 5 parts of Poria cocos, 4 parts of Ligusticum wallichii, 6 parts of Radix Codonopsis, north
4 parts of stilbene, 5 parts of the bighead atractylodes rhizome, 6 parts of saline cistanche, 3 parts of Morinda officinalis, 4 parts of barrenwort, 4 parts of donkey-hide gelatin, 4 parts of rhizoma cyperi, 5 parts of motherwort, Radix Glycyrrhizae 3
Part.
7. a kind of according to any one of claim 1~6 treats the Chinese medicine composition that irregular menstruation promotes pregnancy, its feature
It is：Described rhizoma cyperi is prepared RHIZOMA CYPERI with vinegar.
8. it is according to claim 1 it is a kind of treat irregular menstruation promote pregnancy Chinese medicine composition, it is characterised in that：It is described
Active component is the water extract of bulk drug.
9. it is according to claim 1 it is a kind of treat irregular menstruation promote pregnancy Chinese medicine composition, it is characterised in that：Chinese medicine
The formulation of composition is electuary, powder, tablet, pill, paste, oral liquid, capsule, soft capsule or decoction.
10. it is according to claim 9 it is a kind of treat irregular menstruation promote pregnancy Chinese medicine composition, it is characterised in that：Institute
Stating formulation can be made by adding one or more in adhesive, filler, emulsifying agent, solubilizer, sweetener.
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| CN110432383A (en) * | 2019-08-09 | 2019-11-12 | 内蒙古自治区农牧业科学院 | It is a kind of to promote the sexual maturity the mongolian veterinary drug additive and preparation method thereof of progestogenic for ewe |
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