CN110432383A - It is a kind of to promote the sexual maturity the mongolian veterinary drug additive and preparation method thereof of progestogenic for ewe - Google Patents

It is a kind of to promote the sexual maturity the mongolian veterinary drug additive and preparation method thereof of progestogenic for ewe Download PDF

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Publication number
CN110432383A
CN110432383A CN201910732057.3A CN201910732057A CN110432383A CN 110432383 A CN110432383 A CN 110432383A CN 201910732057 A CN201910732057 A CN 201910732057A CN 110432383 A CN110432383 A CN 110432383A
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radix
parts
ewe
additive
progestogenic
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侯勇跃
李锋
裴乐
刘秀丽
侯恩泽
訾云飞
刘钰
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Inner Mongolia Academy of Agricultural and Animal Husbandry Sciences
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Inner Mongolia Academy of Agricultural and Animal Husbandry Sciences
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K10/00—Animal feeding-stuffs
    • A23K10/30—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23K—FODDER
    • A23K50/00—Feeding-stuffs specially adapted for particular animals
    • A23K50/10—Feeding-stuffs specially adapted for particular animals for ruminants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/24—Heavy metals; Compounds thereof
    • A61K33/26—Iron; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/48—Reproductive organs
    • A61K35/50—Placenta; Placental stem cells; Amniotic fluid; Amnion; Amniotic stem cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232—Angelica
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/233—Bupleurum
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/23—Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/236—Ligusticum (licorice-root)
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/25—Araliaceae (Ginseng family), e.g. ivy, aralia, schefflera or tetrapanax
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/29—Berberidaceae (Barberry family), e.g. barberry, cohosh or mayapple
    • A61K36/296—Epimedium
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/34—Campanulaceae (Bellflower family)
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    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481—Astragalus (milkvetch)
    • A—HUMAN NECESSITIES
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/18—Magnoliophyta (angiosperms)
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    • A61K36/64—Orobanchaceae (Broom-rape family)
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/65—Paeoniaceae (Peony family), e.g. Chinese peony
    • A—HUMAN NECESSITIES
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/74—Rubiaceae (Madder family)
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    • A61K36/185—Magnoliopsida (dicotyledons)
    • A61K36/80—Scrophulariaceae (Figwort family)
    • A61K36/804—Rehmannia
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    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis

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Abstract

It promotes the sexual maturity the mongolian veterinary drug additive and preparation method thereof of progestogenic, including monarch drug in a prescription the invention discloses a kind of for ewe: each 30 parts of Herba Epimedii, actinolite, Radix Astragali；Ministerial drug: Radix Angelicae Sinensis, Radix Codonopsis, Radix Paeoniae Alba, radix paeoniae rubra, Rhizoma Chuanxiong, fructus lycii, Radix Glycyrrhizae and each 20 parts of cape jasmine；Adjutant: myrobalan, radix bupleuri, Rehmannia glutinosa and each 10 parts of Radix Notoginseng；Make medicine: each 10 parts of Herba Cistanches, Goat Placenta powder.The additive using non-stimulated non-antibiotics production without side-effects, have many advantages, such as efficiently, it is low toxicity, nonirritant, may also reach up the effect of activating microcirculation and removing stasis medicinal, temperature palace kidney tonifying.

Description

It is a kind of to promote the sexual maturity the mongolian veterinary drug additive and preparation method thereof of progestogenic for ewe
Technical field:
It is out of heat that the present invention relates to farm animals, infertility field, specially a kind of to promote the sexual maturity the illiteracy of progestogenic for ewe Veterinary additive and preparation method thereof.
Background technique:
Inner Mongolia Autonomous Region is that traditional herding sparetime university saves, mutton sheep production for a long time always with native pasture herd for It is main.In recent years, with the continuous propulsion of ecological protection policy, the scale and range of agent for rearing and fattening meat sheep are also constantly expanding, And ewe infertility directly affects the fertility of sheep, brings serious economic loss to sheep husbandry, is to cause sheep husbandry economy One of the important diseases that benefit reduces.The toxic side effects such as anti-medicine, residual, distortion are also easy to produce using western medicine ewe infertility, Root is controlled not effect a permanent cure.The drawbacks of in order to overcome chemicals to bring, promotes the sustainable development of animal husbandry, seeks new preparation to mention High culture efficiency, the research and development and popularization for carrying out scientific, efficient, inexpensive, practical plant source green mongolian veterinary drug additive are compeled in eyebrow Eyelash.
Herba Epimedii, actinolite, Radix Astragali etc. are compatible with the environment from naturally, can degrade or be metabolized as in the environment letter Single native compound.By to natural mongolian veterinary drug effective use, the usage amount of chemical drugs can be not only reduced, and life can be reduced The accumulation of chemicals in object chain.
Summary of the invention:
The purpose of the present invention is in view of the drawbacks of the prior art, provide it is a kind of for ewe promote the sexual maturity progestogenic mongolian veterinary drug addition Agent and preparation method thereof, to solve the problems, such as that above-mentioned background technique proposes.
To achieve the above object, the present invention provides following technological invention: a kind of to add for the promote the sexual maturity mongolian veterinary drug of progestogenic of ewe Add agent, including monarch drug in a prescription, ministerial drug, adjutant and make medicine,
Monarch drug in a prescription: each 30 parts of Herba Epimedii, actinolite, Radix Astragali；
Ministerial drug: Radix Angelicae Sinensis, Radix Codonopsis, Radix Paeoniae Alba, radix paeoniae rubra, Rhizoma Chuanxiong, fructus lycii, Radix Glycyrrhizae and each 20 parts of cape jasmine；
Adjutant: myrobalan, radix bupleuri, Rehmannia glutinosa and each 10 parts of Radix Notoginseng；
Make medicine: each 10 parts of Herba Cistanches, Goat Placenta powder.
It is a kind of for ewe promote the sexual maturity progestogenic mongolian veterinary drug additive preparation method, specific step is as follows；
Step 1: Herba Epimedii, actinolite, each 30 parts of Radix Astragali are pulverized and mixed by feeding；Radix Angelicae Sinensis, Radix Codonopsis, Radix Paeoniae Alba, radix paeoniae rubra, river Rhizome of chuanxiong, fructus lycii, Radix Glycyrrhizae and each 20 parts of cape jasmine；Myrobalan, radix bupleuri, Rehmannia glutinosa and each 10 parts of Radix Notoginseng；Herba Cistanches and each 10 parts of Goat Placenta powder Raw material carry out cleaning, drying；
Step 2: the raw material that step 1 is taken is carried out to obtain mixture A after being crushed to the sieving mixing of 60-80 mesh；
Step 3: being put into pulverizing mill for the mixture A of step 2 and pulverize, and obtaining granularity is 300-400 purpose Mixture B is the additive.
The beneficial effects of the present invention are:
The ewe promote the sexual maturity progestogenic mongolian veterinary drug feed addictive using non-stimulated non-antibiotics production without side-effects, The additive of the developments such as Herba Epimedii, actinolite, Radix Astragali is to be developed into additive from the plant tissue for promoting the sexual maturity progestational substance. Have many advantages, such as efficient, less toxic, nonirritant, the progestogenic of promoting the sexual maturity for meeting ewe is stingless from traditional organic chemicals to animal Sharp, without side-effects, harmonious object converts development trend.Ewe promote the sexual maturity progestogenic mongolian veterinary drug feed addictive main component derive from from Green plants between so, it is compatible with phytophagous ewe vivo environment, degradation in vivo or it can be metabolized as simple native compound, The final product cleared up in body is carbon dioxide and water, and the promote the sexual maturity mongolian veterinary drug feed addictive of progestogenic of the ewe has height The advantages that imitating, is less toxic, nonirritant may also reach up the effect of activating microcirculation and removing stasis medicinal, warm palace kidney tonifying.
Specific embodiment:
The preferred embodiments of the present invention will be described in detail below, so that advantages and features of the invention can be easier to by this Field personnel understanding, so as to make a clearer definition of the protection scope of the present invention.
Embodiment: the present invention provides a kind of technological invention: it is a kind of to promote the sexual maturity the mongolian veterinary drug additive of progestogenic for ewe, including Monarch drug in a prescription, ministerial drug, adjutant and make medicine,
Monarch drug in a prescription: each 30 parts of Herba Epimedii, actinolite, Radix Astragali；
Ministerial drug: Radix Angelicae Sinensis, Radix Codonopsis, Radix Paeoniae Alba, radix paeoniae rubra, Rhizoma Chuanxiong, fructus lycii, Radix Glycyrrhizae and each 20 parts of cape jasmine；
Adjutant: myrobalan, radix bupleuri, Rehmannia glutinosa and each 10 parts of Radix Notoginseng；
Make medicine: each 10 parts of Herba Cistanches, Goat Placenta powder.
It is a kind of for ewe promote the sexual maturity progestogenic mongolian veterinary drug additive preparation method,
Specific step is as follows；
Step 1: Herba Epimedii, actinolite, each 30 parts of Radix Astragali are pulverized and mixed by feeding；Radix Angelicae Sinensis, Radix Codonopsis, Radix Paeoniae Alba, radix paeoniae rubra, river Rhizome of chuanxiong, fructus lycii, Radix Glycyrrhizae and each 20 parts of cape jasmine；Myrobalan, radix bupleuri, Rehmannia glutinosa and each 10 parts of Radix Notoginseng；Herba Cistanches and each 10 parts of Goat Placenta powder Raw material carry out cleaning, drying；
Step 2: the raw material that step 1 is taken is carried out to obtain mixture A after being crushed to the sieving mixing of 60-80 mesh；
Step 3: being put into pulverizing mill for the mixture A of step 2 and pulverize, and obtaining granularity is 300-400 purpose Mixture B is the additive.
Application method
Spice is taken, and every daily 10 parts of adult ewe, is used in conjunction 7-10 days.It is promoted the sexual maturity progestogenic by the ewe that the invention produces Mongolian veterinary drug feed addictive not only can be reach promote the sexual maturity but also progestogenic at the same do not generate chemicals stimulation triple effects.
Monarch drug in a prescription: Herba Epimedii, enhancement hormone secretion can raise libido, and have the effect for promoting sexual function；Actinolite, it is main The effect wanted is exactly to carry out sterile treatment, improves sexual excitement；Radix Astragali, tonifying Qi and lifting yang (compare for sagging caused by the internal organ cold of insufficiency type Such as gastroptosis, metroptosis, rectal prolapse, diarrhea), myogenic torr sore, detumescencing diuresis.
Ministerial drug: Radix Angelicae Sinensis has the effect of replenishing qi and blood, qi-restoratives damage；Radix Codonopsis, tonifying middle-Jiao and Qi, strengthening spleen and tonifying lung, strengthen immunity change The effects of kind microcirculation enhancing hematopoiesis function；Radix Paeoniae Alba holds back negative blood-nourishing, soft liver analgesic, suppressing liver-YANG；Radix paeoniae rubra has yin-nourishing, row The stasis of blood, analgesic, cool blood, detumescence effect；Rhizoma Chuanxiong, is usually used in blood-activating and qi-promoting, wind-expelling pain-stopping, and promoting blood circulation effect is suitable for hemostasis extensively Block various illnesss；Fructus lycii, the effects of promoting immune, removing free radical, liver protection, protection and improve reproductive function；Radix Glycyrrhizae, tonifying spleen QI invigorating grows cough moistening lung, emergency removing toxic substances, hundred medicines that reconcile；Cape jasmine, purging intense heat, clearing heat and promoting diuresis, clearing liver, swelling and pain relieving.
Adjutant: myrobalan, astringing lung-QI, puckery intestines, lower gas.Control chronic cough, chronic diarrhea, protracted dysentery, rectal prolapse, hematochezia, metrorrhagia and metrostaxis, frequent micturition etc.；Radix bupleuri, Stagnation of QI due to depression of the liver, rectal prolapse, uterus fall off；Rehmannia glutinosa cures mainly the deficiency of liver-yin and kidney-yin, Heat Diabetes, blood deficiency chlorosis, metrostaxis etc.；Three Seven, hemostasis enrich blood, enhance be immunized etc..
Make medicine: Herba Cistanches, clinic are mainly used for treating kidney deficiency and negative blood failure, the qi and blood deficiency of Yin, infertility etc.；Goat Placenta Powder, enhancing physical strength, promotion hematopoiesis function, raising immunity etc..
Recipe ingredient:
Each 30 parts of Herba Epimedii, actinolite, Radix Astragali, Radix Angelicae Sinensis, Radix Codonopsis, Radix Paeoniae Alba, radix paeoniae rubra, Rhizoma Chuanxiong, fructus lycii, Radix Glycyrrhizae, cape jasmine each 20 Part, myrobalan, radix bupleuri, Rehmannia glutinosa, each 10 parts of Radix Notoginseng, each 10 parts of Herba Cistanches, Goat Placenta powder.
Method foundation:
Mongolian veterinary drug coarse crushing medicine is significant in efficacy in common, but pharmaceutical quantities are big, and responding time is long, and World Science skill Art --- just it has been proposed that the theory of micronized Chinese medicine in the modernization of Chinese medicine: the effective component of Chinese medicine is typically distributed about into the cell With cytoplasm, and based on intracellular.The cell dia of Chinese medicine is generally 10-100um, crushes (60-80 through usual manner Mesh) after, chief destructive is intercellular layer between cell, and most cells are the molten of complete, intracellular effective medicinal ingredient Needing guiding through several or even dozens of cell wall out just can enter in solvent, then be absorbed by organisms, and quite a few cell Interior effective component cannot pass through cell wall and enter solvent, i.e., does not generate pharmacological action.Mongolian veterinary drug is not only broken after pulverizing Intercellular layer between bad cell, and cell is smashed, since its surface area and porosity increase, to have good absorption Property, adsorptivity, dissolubility, chemical activity etc..
Preparation process
1. above each taste medicine is weighed by prescribed dose respectively is crushed to 60-80 mesh, sieving for standby；
2. the mixture 1. obtained to be carried out to pulverizing mill again to pulverize；
3. sieving is uniformly mixed after the gained micronized processing of granularity 300-400 purpose.
Production invention verifying
Currently, being usually base adjusting and restoring whole body function in ewe is out of heat or heat conception failture is treated Plinth, using reproductive hormone partner treatment.That there are individual reactions is different due to hormone therapy, damage ovary and uterus function and The drawbacks such as livestock products hormone residues, therefore be not recommended to use, the present invention is promoted the sexual maturity using natural plants with minerals resource to reach Progestogenic effect.Follicle-stimulating hormone, luteotropin and inspection are checked using clinical tire inspection observation cure rate and laboratory ELISA method now Serum progesterone concentration is surveyed to evaluate therapeutic effect of the invention.
(1) materials and methods
Experimental animal and grouping selection Siziwang Banner Divine Land cultivation profession, by breeding history and medical history investigation, clinical examination, The 3-5 parity of free from infection, parasitic disease and genital diseases, postpartum 60d or more heat not yet is produced ewe (local Mongolia Sheep) 60,3 groups are randomly divided into, 1 group, as control, is not added feed addictive and directly fed with feed, and 2 groups use this prescription The additive product feeding for being crushed to 200-300 mesh ultramicro grinding, 3 groups are added this prescription and are crushed to 60-80 using mix fodder Mesh feeding carries out a tire inspection for every 7 days.
(2) testing index
Cure rate is checked using tire, ELISA method measures Luteinizing Hormone (LH), follicle-stimulating hormone (FSH) and progesterone (P4) concentration.
(3) the full-automatic microplate reader of key instrument equipment ELX-808,50sTringaVet Portable B-ultrasonic instrument for veterinary use.
(4) data processing
The significance of difference (P < 0.05), is as a result indicated with mean+SD.
(5) result and analysis
Cure rate of the table 1 to ewe out of heat
As it can be seen from table 1 additive cure rate of the invention 95%, has progestogenic effect of promoting the sexual maturity well.
2 blood-serum P of table, 4 concentration ng/ml
Note: different lowercases indicate different time points significant difference (P < 0.05) in each group group, capitalization A, B, C Same time point significant difference (P < 0.05) between indicating 1,2,3 group
2 are shown in Table with 4 concentration of blood-serum P after additive.At ultramicro grinding group (of the present invention group), present first by high concentration before taking medicine The trend risen after drop, 7d start to significantly reduce (P < 0.05), and 10d starts to increase (P < 0.05) after minimizing (P < 0.05), 21d is increased to the level close to 3d, its level of 3d~21d is substantially less than control group (P < 0.05)；It is crushed to 60-80 mesh group, In 11d produces significant decrease, and 14d is restored to original level again；Control group does not change (P > 0.05).So as to see Coarse crushing is slow and short to 4 action time of blood-serum P out, the present invention make invention long action time and it is fast, corpus luteum can be significantly changed Functional state.
3 serum FSH concentration ng/ml of table
Note: different lowercases indicate different time points significant difference (P < 0.05) in each group group, capitalization A, B, C Same time point significant difference (P < 0.05) between indicating 1,2,3 group
Serum FSH concentration is shown in Table 3 after feeding additive.In ultramicro grinding group, by the low concentration before feeding additive in first Trend is dropped after rising, is gradually significantly increased since 3d (P < 0.05), reduces (P < 0.05) after 7d to peak value, 14~21d is down to It is horizontal before medication；Coarse crushing group only has 9d concentration to improve, but 14d is just without effect quickly, and control group is without obvious Change (P > 0.05).Hypophysis regularity can be promoted to discharge FSH the result shows that taking invention formulation.
4 serum Lh concentration ng/ml of table
Note: different lowercases indicate different time points significant difference (P < 0.05) in each group group, capitalization A, B, C Same time point significant difference (P < 0.05) between indicating 1,2,3 group
Serum Lh concentration is shown in Table 4 after feeding additive.In ultramicro grinding group, for LH concentration in trend of falling after rising, 1~7d is slow Slow to increase, 10d starts to reduce after being rapidly reached peak value (P < 0.05), until 14d is rapidly decreased to lower than 1~7d level, but it is horizontal It is above control group；Coarse crushing group is improved up to the apparent concentration of 14d Shi Caiyou, but 21d has just restored original level；Control Group does not change (P > 0.05).The result shows that the regularity that this additive can promote hypophysis to generate LH discharges.
6, clinical effectiveness is tested
(1) trial drug
Herba Epimedii, actinolite, Radix Astragali, Radix Angelicae Sinensis, Radix Codonopsis, Radix Paeoniae Alba, radix paeoniae rubra, Rhizoma Chuanxiong, fructus lycii, Radix Glycyrrhizae, cape jasmine, myrobalan, radix bupleuri, Rehmannia glutinosa, Radix Notoginseng, Herba Cistanches, Goat Placenta powder are purchased from Anguo Shore Kang Yuan medicine materical crude slice Co., Ltd.60 meshes are crossed with common grinder Crushing is common coarse powder；Micro mist is gained (granularity 300-400 mesh) after being pulverized common coarse powder with pulverizing mill again.
(2) experimental animal
Select Inner Mongol friend join farming and animal husbandry development in science and technology Co., Ltd 109 out of heat, heat conception failture ewes into Row diagnosis and treatment is suffered from sheep to selected 109 and is diagnosed, and is divided into 5 groups by card type: 1 group of test: the ewe of heat conception failture totally 19 Only, show as the dry tongue of tired mind, yellow urine, mouth it is dry, it is dispirited it is out of strength, coat is simple and unadorned, red tongue with yellowish fur, excrement are smelly and dry, deeptensepulse is counted accurately, Belong to syndrome of deficiency of kidney yin.Test 2 groups: ewe 23 of conception failture of inseminating after heat, the general blueness of performance dryness of the mouth and throat, mental fatigue with loss of appetite, less fur, Veins string is empty, belongs to syndrome of stagnation of liver qi and blood deficiency.Test 3 groups: ewe 15 of conception failture of inseminating after long-term out of heat or heat, performance palpitation with fear, It is dynamic then breathe heavily, body show condition is strong, leukorrhagia is sticky and amount is more, cyanotic lips, tongue moss is greasy, stringy and hesitant pulse is sliding, belong to liver syndrome of qi stagnation and blood stasis.Examination Test 4 groups: the ewe of conception failture 16 after heat, show as tired mind, be slow in action, spiritlessness and weakness, coat are simple and unadorned, borborygmus excrement Half congealed, the clear frequent micturition of urine, tongue fur are light white, pulse condition is heavy late, belong to syndrome of deficiency of kidney yang.Testing 5 groups to be with 6 groups of test is some infertile ewes Middle stochastic averagina is assigned with each 18.Then unify conventinal breeding.
(3) test method
1., with chemicals medication 3 times of purchase, once a day, additive capacity is 10 parts/, unified by grouping medication With 7 days, blank group did not had to product.
2. 7d, 14d, 21d observe the heat situation after inspection additive and chemical agent, two weeks, three weeks, divide after four weeks It carry out not tire inspection record.
(4) result and analysis
From situation of being impregnated after heat, breeding after test 109 ewe additives of each group, infertile ewe is with adding Add and amount to heat 71 after agent, Oestrus rate 97.3% is become pregnant 63, conception rate 88.7%, and chemicals is promoted the sexual maturity progestational agents heat Rate is 83.3%, conception rate 86.7%, it is seen that the effect of this additive has had exceeded chemicals, and nontoxic, noresidue, It is without side-effects, it is shown in Table 5.
Heat and fertilization situation after the infertile ewe additive of table 5 and chemical agent
According to traditional Chinese medical theory, the Etiological of the non-congenital infertility of ewe should be in kidney,liver,spleen.In order to make to distinguish It is more accurate to demonstrate,prove, and makes Estrus synchronization by diagnosis and treatment to the card type parting for suffering from non-congenital infertility ewe It significantly improves.
The ewe promote the sexual maturity progestogenic mongolian veterinary drug feed addictive using non-stimulated non-antibiotics production without side-effects, The additive of the developments such as Herba Epimedii, actinolite, Radix Astragali is to be developed into additive from the plant tissue for promoting the sexual maturity progestational substance. Have many advantages, such as efficient, less toxic, nonirritant, the progestogenic of promoting the sexual maturity for meeting ewe is stingless from traditional organic chemicals to animal Sharp, without side-effects, harmonious object converts development trend.Ewe promote the sexual maturity progestogenic mongolian veterinary drug feed addictive main component derive from from Green plants between so, it is compatible with phytophagous ewe vivo environment, degradation in vivo or it can be metabolized as simple native compound, The final product cleared up in body is carbon dioxide and water, and the promote the sexual maturity mongolian veterinary drug feed addictive of progestogenic of the ewe has height The advantages that imitating, is less toxic, nonirritant may also reach up the effect of activating microcirculation and removing stasis medicinal, warm palace kidney tonifying.
The embodiments described above only express several embodiments of the present invention, and the description thereof is more specific and detailed, but simultaneously It cannot therefore be construed as limiting the scope of the patent.It should be pointed out that coming for those of ordinary skill in the art It says, without departing from the inventive concept of the premise, various modifications and improvements can be made, these belong to guarantor of the invention Shield.

Claims (2)

1. a kind of promote the sexual maturity the mongolian veterinary drug additive of progestogenic for ewe, including monarch drug in a prescription, ministerial drug, adjutant and make medicine, it is characterised in that:
Monarch drug in a prescription: each 30 parts of Herba Epimedii, actinolite, Radix Astragali；
Ministerial drug: Radix Angelicae Sinensis, Radix Codonopsis, Radix Paeoniae Alba, radix paeoniae rubra, Rhizoma Chuanxiong, fructus lycii, Radix Glycyrrhizae and each 20 parts of cape jasmine；
Adjutant: myrobalan, radix bupleuri, Rehmannia glutinosa and each 10 parts of Radix Notoginseng；
Make medicine: each 10 parts of Herba Cistanches, Goat Placenta powder.
2. it is a kind of as described in claim 1 for ewe promote the sexual maturity progestogenic mongolian veterinary drug additive preparation method, which is characterized in that Specific step is as follows；
Step 1: Herba Epimedii, actinolite, each 30 parts of Radix Astragali are pulverized and mixed by feeding；Radix Angelicae Sinensis, Radix Codonopsis, Radix Paeoniae Alba, radix paeoniae rubra, Rhizoma Chuanxiong, Fructus lycii, Radix Glycyrrhizae and each 20 parts of cape jasmine；Myrobalan, radix bupleuri, Rehmannia glutinosa and each 10 parts of Radix Notoginseng；Herba Cistanches and each 10 parts of original of Goat Placenta powder Material carries out cleaning, drying；
Step 2: the raw material that step 1 is taken is carried out to obtain mixture A after being crushed to the sieving mixing of 60-80 mesh；
Step 3: being put into pulverizing mill for the mixture A of step 2 and pulverize, and obtains the mixing that granularity is 300-400 mesh Object B is the additive.
CN201910732057.3A 2019-08-09 2019-08-09 It is a kind of to promote the sexual maturity the mongolian veterinary drug additive and preparation method thereof of progestogenic for ewe Pending CN110432383A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116077566A (en) * 2023-02-01 2023-05-09 内蒙古自治区农牧业科学院 Chinese herbal medicine composition for promoting oestrus of cows and preparation method thereof

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101810743A (en) * 2009-12-17 2010-08-25 河南省康星药业有限公司 Normal temperature preparation method for submicron powder of sexual maturity promoting powder
CN102114153A (en) * 2009-12-31 2011-07-06 天津瑞普生物技术股份有限公司 Traditional Chinese medicine preparation for improving oestrus and pregnancy of dams and preparation method thereof
CN104322995A (en) * 2014-10-24 2015-02-04 遵义博信科技咨询有限责任公司 Ewe estrus promoting feed and preparation method thereof
CN105497412A (en) * 2015-12-16 2016-04-20 孙自富 Agentia for promoting oestrus and ovulation of ewes and preparing method thereof
CN105614093A (en) * 2015-12-18 2016-06-01 南昌傲农生物科技有限公司 Feed additive for improving production performance of sows and application of feed additive
CN106728640A (en) * 2016-12-14 2017-05-31 赖新生 It is a kind of to treat the Chinese medicine composition that irregular menstruation promotes pregnancy
CN108403903A (en) * 2018-05-08 2018-08-17 佛山市粤三胖农业科技有限公司 A kind of sow with functions of promoting sexual maturity is scattered
CN108434308A (en) * 2018-03-27 2018-08-24 温爱群 The feed addictive and preparation method thereof for promoting female rabbit heat, improving conception rate
CN108837131A (en) * 2018-08-27 2018-11-20 维康腾达生物科技有限公司 A kind of Chinese herbal compounds are promoted the sexual maturity scattered and preparation method thereof

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101810743A (en) * 2009-12-17 2010-08-25 河南省康星药业有限公司 Normal temperature preparation method for submicron powder of sexual maturity promoting powder
CN102114153A (en) * 2009-12-31 2011-07-06 天津瑞普生物技术股份有限公司 Traditional Chinese medicine preparation for improving oestrus and pregnancy of dams and preparation method thereof
CN104322995A (en) * 2014-10-24 2015-02-04 遵义博信科技咨询有限责任公司 Ewe estrus promoting feed and preparation method thereof
CN105497412A (en) * 2015-12-16 2016-04-20 孙自富 Agentia for promoting oestrus and ovulation of ewes and preparing method thereof
CN105614093A (en) * 2015-12-18 2016-06-01 南昌傲农生物科技有限公司 Feed additive for improving production performance of sows and application of feed additive
CN106728640A (en) * 2016-12-14 2017-05-31 赖新生 It is a kind of to treat the Chinese medicine composition that irregular menstruation promotes pregnancy
CN108434308A (en) * 2018-03-27 2018-08-24 温爱群 The feed addictive and preparation method thereof for promoting female rabbit heat, improving conception rate
CN108403903A (en) * 2018-05-08 2018-08-17 佛山市粤三胖农业科技有限公司 A kind of sow with functions of promoting sexual maturity is scattered
CN108837131A (en) * 2018-08-27 2018-11-20 维康腾达生物科技有限公司 A kind of Chinese herbal compounds are promoted the sexual maturity scattered and preparation method thereof

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
官丽萍等: "张庆文教授治疗继发性闭经的经验", 《甘肃中医学院学报》 *
范开 等: "《中兽医方剂辨证应用及解析》", 30 November 2005, 化学工业出版社 *

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116077566A (en) * 2023-02-01 2023-05-09 内蒙古自治区农牧业科学院 Chinese herbal medicine composition for promoting oestrus of cows and preparation method thereof
CN116077566B (en) * 2023-02-01 2024-03-19 内蒙古自治区农牧业科学院 Chinese herbal medicine composition for promoting oestrus of cows and preparation method thereof

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Application publication date: 20191112