CN102335416A - Compound Chinese medicinal composition for treating hog cholera and preparation method thereof - Google Patents

Abstract

The invention discloses a compound Chinese medicinal composition for treating hog cholera and a preparation method thereof, relating to the field of animal medicines. The preparation method comprises the following steps of: (1) sieving all components (except interferon) in the prescription with a 500-mesh sieve after ultra-fine pulverization; (2) taking 15-25 parts of propolis, 3-10 parts of interferon for pigs, 10-25 parts of Cyrtomium fortune and 15-25 parts of selfheal according to weight part and mixing for 5-10 minutes until well mixing; (3) taking 10-20 parts of gypsum, 10-250 parts of dandelion, 10-25 parts of rhizoma anemarrhenae and 15-30 parts of rhubarb according to weight part and mixing for 5-10 minutes until well mixing; (4) combining the compositions prepared in the steps (2) and (3), continuing to mix for 10-15 minutes until well mixing. The invention has the beneficial effects of rational prescription and simple preparation; the composite has the advantages of no toxic effect, no pollution, no drug residue and no drug resistance, ultra-micro pulverization, high bioavailability, obvious curative effect and special effect for treating hog cholera through the clinical evidence.

Description

A kind of herbal mixture composition and method of making the same of treating swine fever

Technical field

The present invention relates to animal medicine and method for preparing field, particularly a kind of herbal mixture composition and method of making the same of treating swine fever.

Background technology

Swine fever is a kind of acute, heating, the contagious disease that is caused by swine fever virus.Have hyperinfection property and lethal.It is characterized in that: acute, be the variation of deteriorated blood property, the organa parenchymatosum is hemorrhage, necrosis and infarction; The chronic fiber disposition necrotic enteritis that is, often there are paratyphoid fever and Bacillus pasteurii disease secondary in the later stage.Primary disease is an infected pigs under field conditions (factors), and the pig of all ages and classes, sex, kind and wild boar be susceptible all, all can take place throughout the year.It is one of principal disease of harm pig industry.

The pathogen of primary disease is a swine fever virus, and this disease spreads all over more or less a hundred country of five continents, distributes very extensively.At present, treat this disease the most frequently used be Chinese medicine and antiviral Western medicine, Chinese medicine is because its prescription is unreasonable or just simple the pulverizing, and particle diameter is excessive, and drug release is slower, causes its bioavailability lower, clinical effectiveness is not fine; And the various antiviral agents such as the Ministry of Agriculture such as ribavirin, amantadine ban use of.

Therefore researching and developing a kind of specific medicament of treating the drug residue free of swine fever, the generation that has no drug resistance is one of this field scientific research technical staff new problem anxious to be solved.

Summary of the invention

The objective of the invention is to overcome above-mentioned weak point, provide that a kind of reasonable recipe, preparation are simple, micronizing, bioavailability are high, effect obviously, have no drug resistance and the herbal mixture composition and method of making the same of effective treatment swine fever of drug residue.

Following for realizing the embodiment that above-mentioned purpose the present invention adopted: a kind of herbal mixture compositions of treating swine fever, by following component by weight mixed preparing form: propolis 15-25 part, pig are with interferon 3-10 part, Rhizoma Osmundae 10-25 part, Spica Prunellae 15-25 part, Gypsum Fibrosum 10-20 part, Herba Taraxaci 10-25 part, Rhizoma Anemarrhenae 10-25 part, Radix Et Rhizoma Rhei 15-30 part.

Said various component optimum ratio amount is: 20 parts of propolis, pig are with 5 parts of interferon, 20 parts of Rhizoma Osmundae, 20 parts of Spica Prunellaes, 15 parts in Gypsum Fibrosum, 20 parts of Herba Taraxacis, 20 parts of the Rhizoma Anemarrhenaes, 25 parts of Radix Et Rhizoma Rhei.

A kind of herbal mixture preparation of compositions method of treating swine fever, carry out as follows:

(1) the various compositions (except the interferon) in the prescription is crossed 500 mesh sieves after the micronizing respectively;

(2) take by weighing propolis 15-25 part, pig by weight with interferon 3-10 part, Rhizoma Osmundae 10-25 part, Spica Prunellae 15-25 part, mix 5-10 minute to even;

(3) take by weighing Gypsum Fibrosum 10-20 part, Herba Taraxaci 10-25 part, Rhizoma Anemarrhenae 10-25 part, Radix Et Rhizoma Rhei 15-30 part by weight, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.

The medicinal property of each component is following:

Propolis: bitter, hot, cold, return spleen, stomach warp, have the function of anti-inflammation, antalgesic-antipruritic, promotion tissue regeneration, raising immunity, antiallergic oxidation, hemostasis, protection gastrointestinal mucosa.

Interferon: be a kind of broad-spectrum disease resistance toxic agent, RNA and DNA viruses are had inhibition or killing action; Can inducing apoptosis of tumour cell, thus kill tumor cell; Interferon all has immunological enhancement to humoral immunization, cellular immunization, macrophage and NK cell.

Rhizoma Osmundae: hot, bitter, cold, return lung, liver, stomach warp, have the function of heat-clearing and toxic substances removing, cooling blood for hemostasis; Cure mainly pestilence, pharyngeal swelling, sore swollen toxin, floating pulse, pathopyretic ulcer etc.

Spica Prunellae: bitter, cold, hot, return liver, gallbladder meridian, have purging liver-fire, make eye bright, mass dissipating and swelling eliminating, diuretic function; It is swollen etc. to cure mainly pestilence, conjunctival congestion and swelling pain, acute mastitis, skin ulcer.

Herba Taraxaci: bitter, sweet, cold, return liver, stomach warp, have the function of heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, inducing diuresis for treating stranguria syndrome; Cure mainly sore, lung abscess, pharyngalgia, jaundice due to damp-heat, pyretic stranguria.

Gypsum Fibrosum: attach to the lung and stomach meridians in sweet, hot, Great Cold, have the function of clearing away heat-fire, promoting the production of body fluid to quench thirst; Cure mainly fever caused by exogenous pathogenic factors, lung-heat dyspnea with rapid and short breath, high fever coma etc.

The Rhizoma Anemarrhenae: bitter, sweet, cold, return lung, stomach, kidney channel, have clearing away heat-fire, nourshing Yin and drynsessmoistening prescription function; Cure mainly fever caused by exogenous pathogenic factors, gastric heat, cough due to lung-heat, dryness of the intestine constipation, interior-heat caused by deficiency of YIN etc.

Radix Et Rhizoma Rhei: bitter, cold, return spleen, stomach, large intestine, liver, pericardium channel, have the function of purging heat and dredging bowels, removing pathogenic heat from blood and toxic substance from the body, removing mass clots absorbing; Cure mainly excess-heat constipation, combined symptoms, the yellow furunculosis of skin ulcer, conjunctival congestion and swelling pain etc.

More than all flavor Chinese medicine according to the Chinese medical theory compatible combination, to pathogenic microorganism, clinical symptoms and the pathological change of swine fever, the effect of performance treating both the principal and secondary aspects of a disease.

The invention has the beneficial effects as follows: reasonable recipe, preparation is simple, and substep mixes more even; Chinese medicine composition is pollution-free, no drug residue, have no drug resistance, and cost is low, and it is wide to draw materials, and micronizing, bioavailability are high, the curative effect highly significant.The present invention is according to Chinese veterinarian's traditional theory; Optimize this seven flavors Chinese medicine, and make them form pure Chinese powder medicine according to optimum ratio, clinical practice proves; The treatment swine fever there is specially good effect; And make its product meat reach nuisanceless requirement, satisfy the export standard of product, guaranteed that effectively people's is healthy.

The specific embodiment

Below in conjunction with preferred embodiment, to details are as follows according to the specific embodiment provided by the invention:

Embodiment 1

A kind of herbal mixture composition and method of making the same of treating swine fever: carry out as follows: (every part by 10g)

(1) the various compositions (except the interferon) in the prescription is crossed 500 mesh sieves after the micronizing respectively;

(2) take by weighing 150 parts of propolis, pig by weight with 30 parts of interferon, 100 parts of Rhizoma Osmundae, 150 parts of Spica Prunellaes, mix 5-10 minute to even;

(3) take by weighing 100 parts in Gypsum Fibrosum, 100 parts of Herba Taraxacis, 100 parts of the Rhizoma Anemarrhenaes, 150 parts of Radix Et Rhizoma Rhei by weight, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.

Embodiment 2

A kind of pure Chinese medicine composition of treating swine fever and preparation method thereof: carry out as follows: (every part by 10g)

(1) the various compositions (except the interferon) in the prescription is crossed 500 mesh sieves after the micronizing respectively;

(2) take by weighing 200 parts of propolis, pig by weight with 50 parts of interferon, 150 parts of Rhizoma Osmundae, 200 parts of Spica Prunellaes, mix 5-10 minute to even;

(3) take by weighing 150 parts in Gypsum Fibrosum, 150 parts of Herba Taraxacis, 150 parts of the Rhizoma Anemarrhenaes, 200 parts of Radix Et Rhizoma Rhei by weight, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.

Embodiment 3

A kind of pure Chinese medicine composition of treating swine fever and preparation method thereof: carry out as follows: (every part by 10g)

(1) the various compositions (except the interferon) in the prescription is crossed 500 mesh sieves after the micronizing respectively;

(2) take by weighing 250 parts of propolis, pig by weight with 100 parts of interferon, 250 parts of Rhizoma Osmundae, 250 parts of Spica Prunellaes, mix 5-10 minute to even;

(3) take by weighing 200 parts in Gypsum Fibrosum, 250 parts of Herba Taraxacis, 250 parts of the Rhizoma Anemarrhenaes, 300 parts of Radix Et Rhizoma Rhei by weight, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.

Clinical trial:

With the ill pig of product feeding of the present invention etc., a day dose is: by the every 100g of the present invention, spice 200kg feeds, drinking-water 450kg, every day 2-3 time, logotype 3-5 day; Oral back reaches the purpose of treatment disease through gastrointestinal absorption.

Table is the field applicable cases contrast of the present invention and other medicines treatment swine fever:

Compile	Group	Dead	Cure	Symptom is arranged during end
					I	The blank group	10.5	74.6	14.9
II	The swine fever health is loose and is organized	7.2	80.6	12.2
					III	Chinese medicine composition of the present invention	5.1	87.6	7.3

This clinical effectiveness is through statistical analysis, and present composition treatment group is loose to organize with the swine fever health and compared significant difference (P＜0.05) aspect the cure rate.

Above-mentioned detailed description of pure Chinese medicine composition of this treatment swine fever and preparation method thereof being carried out with reference to embodiment; Be illustrative rather than determinate; Can enumerate out several embodiment according to institute's limited range; Therefore in the variation and the modification that do not break away under the general plotting of the present invention, should belong within protection scope of the present invention.

Claims (3)

1. herbal mixture compositions of treating swine fever, it is characterized in that by following component by weight mixed preparing form: propolis 15-25 part, pig are with interferon 3-10 part, Rhizoma Osmundae 10-25 part, Spica Prunellae 15-25 part, Gypsum Fibrosum 10-20 part, Herba Taraxaci 10-25 part, Rhizoma Anemarrhenae 10-25 part, Radix Et Rhizoma Rhei 15-30 part.

2. a kind of herbal mixture compositions of treating swine fever according to claim 1, it is characterized in that said various component optimum ratio amount is: 20 parts of propolis, pig are with 5 parts of interferon, 20 parts of Rhizoma Osmundae, 20 parts of Spica Prunellaes, 15 parts in Gypsum Fibrosum, 20 parts of Herba Taraxacis, 20 parts of the Rhizoma Anemarrhenaes, 25 parts of Radix Et Rhizoma Rhei.

3. the herbal mixture preparation of compositions method of a treatment swine fever according to claim 1 and 2 is characterized in that carrying out as follows:

(1) the various compositions (except the interferon) in the prescription is crossed 500 mesh sieves after the micronizing respectively;

(2) take by weighing propolis 15-25 part, pig by weight with interferon 3-10 part, Rhizoma Osmundae 10-25 part, Spica Prunellae 15-25 part, mix 5-10 minute to even;

(3) take by weighing Gypsum Fibrosum 10-20 part, Herba Taraxaci 10-25 part, Rhizoma Anemarrhenae 10-25 part, Radix Et Rhizoma Rhei 15-30 part by weight, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.