CN103550705A - Composition for treating infectious tracheobroncheitis and preparation method thereof - Google Patents
Composition for treating infectious tracheobroncheitis and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a composition for treating infectious tracheobroncheitis. The preparation method comprises the following steps: (1) respectively performing superfine grinding on traditional Chinese medicine components in a formula and seiving the components by using a 500 meshes sieve; (2) weighing 15-35 parts of propolis, 10-25 parts of flower bud of lily magnolia, 10-25 parts of white paeony root, 15-25 parts of dried tangerine and 15-35 parts of platycodon grandiflorum and mixing for 5-10 minutes until the mixture is uniform; (3) weighing 10-20 parts of virazole, 5-10 parts of doxycycline hydrochloride, 15-35 parts of liquorice, 15-25 parts of curcuma zedoary and 5-10 parts of pentoxyverine citrate, and mixing for 5-10 minutes until the mixture is uniform; and (4) mixing the mixtures prepared in the steps (2) and (3), and continuously mixing for 10-15 minutes until the composition is uniform. The composition has the beneficial effects that the composition is reasonable in formula and can be prepared simply; an advanced superfine grinding technology is adopted in the preparation process, so that the bioavailability of active ingredients is greatly improved; Chinese and western medicines are combined, and both symptoms and root causes are treated. The clinical application proves that the composition has a special effect of treating infectious tracheobroncheitis and the application prospects is very wide.
Description
Technical field
The present invention relates to treat the composition and method of making the same of Infectious Tracheobroncheitis, particularly a kind of composition and method of making the same that is specifically designed to treatment Infectious Tracheobroncheitis.
Background technology
Infectious bronchitis is commonly referred to that dog coughs or dog nest is coughed disease, have break out, sudden cough, irregularly spit, a kind of hyperinfection respiratory tract disease of the feature such as eye nasal discharge.Be mainly a kind of chronic contagious disease that II type hepatitis infectiosa canis virus causes, mainly present laryngitis, tracheitis, bronchitis, tonsillitis and symptoms of pneumonia, can other bacterial diseasees of secondary infection etc.The dog of all ages and classes, sex, kind all can infect, and mortality rate is very high, is one of main epidemic disease of the foster dog industry of harm.
Current medicine effect is outstanding not, and therefore researching and developing a kind of specific medicament for the treatment of Infectious Tracheobroncheitis is one of this field scientific research technical staff new problem anxious to be resolved.
Summary of the invention
The object of the invention is to overcome above-mentioned weak point, provide that a kind of reasonable recipe, preparation are simple, successful, effectively treat the composition and method of making the same of Infectious Tracheobroncheitis.
Implementation of the present invention is as follows for achieving the above object: a kind of compositions for the treatment of Infectious Tracheobroncheitis, by following component by weight mixed preparing form: propolis 15-35 part, Flos Magnoliae 10-25 part, Radix Paeoniae Alba 10-25 part, Pericarpium Citri Reticulatae 15-25 part, Radix Platycodonis 15-35 part, 1020 parts of virazoles, doxycycline hydrochloride 5-10 part, Radix Glycyrrhizae 15-35 part, Rhizoma Curcumae 15-25 part, pentoxyverine citrate 5-10 part.
Described various component optimum ratio amount is: 25 parts of propolis, 15 parts of Flos Magnoliaes, 15 parts of the Radix Paeoniae Albas, 20 parts of Pericarpium Citri Reticulataes, 25 parts of Radix Platycodoniss, 15 parts of virazoles, 7 parts of doxycycline hydrochloride, 25 parts, Radix Glycyrrhizae, 20 parts of Rhizoma Curcumae, 7 parts of pentoxyverine citrates.
A preparation method for the compositions of Infectious Tracheobroncheitis, carry out as follows:
(1) Chinese medicine ingredients in prescription is carried out respectively after micronizing, cross 500 mesh sieves;
(2) take by weight propolis 15-35 part, Flos Magnoliae 10-25 part, Radix Paeoniae Alba 10-25 part, Pericarpium Citri Reticulatae 15-25 part, Radix Platycodonis 15-35 part, mix 5-10 minute to even;
(3) take by weight virazole 10-20 part, doxycycline hydrochloride 5-10 part, Radix Glycyrrhizae 15-35 part, Rhizoma Curcumae 15-25 part, pentoxyverine citrate 5-10 part, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
The medicinal property of each component is as follows:
Propolis: bitter, acrid, cold, return spleen, stomach warp, have anti-inflammation, pain relieving only overworked, promote tissue regeneration, improve immunity, the function of antiallergic oxidation, hemostasis, protection gastrointestinal mucosa etc.
Flos Magnoliae: pungent, warm, attach to the lung and stomach meridians, there is the function of dispersing wind and cold, clearing the nasal passage; Cure mainly wind and cold nasal obstruction, brain forehead nose pus etc.
The Radix Paeoniae Alba: bitter, acid, be slightly cold, return liver, spleen channel, there is suppressing the hyperactive liver pain relieving, the function of the yin fluid astringing that nourishes blood; Cure mainly deficiecny of liver-YIN, deficiency-heat, dysentery stomachache, spasm of the limbs etc.
Pericarpium Citri Reticulatae: bitter, pungent, warm, return lung, spleen channel, there is the function of regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm; Cure mainly poor appetite, stomachache, tripe is swollen, have loose bowels, productive cough due to phlegm-damp etc.
Radix Platycodonis: bitter, pungent, flat, return lung meridian, there is lung qi dispersing, eliminate the phlegm, the function of sore-throat relieving, evacuation of pus; Cure mainly cough with copious phlegm, laryngopharynx swelling and pain, lung abscess etc.
Radix Glycyrrhizae: sweet, flat, return lung, the heart, spleen channel, there is invigorating the spleen and replenishing QI, expelling phlegm for arresting cough and middle emergency, removing toxic substances, coordinating the actions of various ingredients in a prescription, cushion toxicity, strong function; Cure mainly weakness of the spleen and stomach, cough with asthma, poisoning etc.
Virazole: white crystalline powder is the antiviral drugs of broad spectrum high-effect, is widely used at present the control of viral disease.
Doxycycline hydrochloride: be faint yellow or yellow crystalline powder, tetracycline antibiotics.The mechanism of action is disturb bacterioprotein synthetic, and oral absorption is good.Be mainly used in the infection due to responsive gram positive bacteria and gram negative bacilli and mycoplasma.
Rhizoma Curcumae: acrid, bitter, warm, return liver, spleen channel, there is the function of broken silt removing food stagnancy, promoting the circulation of QI to relieve pain; Cure mainly stagnation of QI-blood, tripe abdominal distention and pain, accumulation of food in the stomach and intes tine due to indigestion, traumatic injury etc.
Wei Lin is dragged in citric acid spray: white crystalline powder is antitussive class medicine, the cough causing for a variety of causes.The mechanism of action is to the selective inhibitory action of coughing centre, still has slight atropine-like effect and local anesthetic action, and heavy dose of have spasmolysis to bronchial smooth muscle, therefore it has central and tip antitussive effect concurrently.
All herbal medicines, for the various factors that causes Infectious Tracheobroncheitis, are brought into play the comprehensive function for the treatment of both the principal and secondary aspects of a disease above.
The invention has the beneficial effects as follows: reasonable recipe, preparation is simple, and substep mixes more even; Chinese medicine and western medicine combination, treating both the principal and secondary aspects of a disease; And making them according to optimum ratio, form said composition, clinical practice proves that treatment Infectious Tracheobroncheitis is had to specially good effect.
The specific embodiment
Below in conjunction with preferred embodiment, to according to the specific embodiment provided by the invention, details are as follows:
Embodiment 1
A kind of composition and method of making the same for the treatment of Infectious Tracheobroncheitis: carry out as follows: (every part by 10g)
(1) Chinese medicine ingredients in prescription is carried out respectively after micronizing, cross 500 mesh sieves;
(2) take by weight 150 parts of propolis, 100 parts of Flos Magnoliaes, 100 parts of the Radix Paeoniae Albas, 150 parts of Pericarpium Citri Reticulataes, 150 parts of Radix Platycodoniss, mix 5-10 minute to even;
(3) take by weight 100 parts of virazoles, 50 parts of doxycycline hydrochloride, 150 parts, Radix Glycyrrhizae, 150 parts of Rhizoma Curcumae, 50 parts of pentoxyverine citrates, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Embodiment 2
A kind of composition and method of making the same for the treatment of Infectious Tracheobroncheitis: carry out as follows: (every part by 10g)
(1) Chinese medicine ingredients in prescription is carried out respectively after micronizing, cross 500 mesh sieves;
(2) take by weight 250 parts of propolis, 150 parts of Flos Magnoliaes, 150 parts of the Radix Paeoniae Albas, 200 parts of Pericarpium Citri Reticulataes, 250 parts of Radix Platycodoniss, mix 5-10 minute to even;
(3) take by weight 150 parts of virazoles, 70 parts of doxycycline hydrochloride, 250 parts, Radix Glycyrrhizae, 200 parts of Rhizoma Curcumae, 70 parts of pentoxyverine citrates, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Embodiment 3
A kind of composition and method of making the same for the treatment of Infectious Tracheobroncheitis: carry out as follows: (every part by 10g)
(1) Chinese medicine ingredients in prescription is carried out respectively after micronizing, cross 500 mesh sieves;
(2) take by weight 350 parts of propolis, 250 parts of Flos Magnoliaes, 250 parts of the Radix Paeoniae Albas, 250 parts of Pericarpium Citri Reticulataes, 350 parts of Radix Platycodoniss, mix 5-10 minute to even;
(3) take by weight 200 parts of virazoles, 100 parts of doxycycline hydrochloride, 350 parts, Radix Glycyrrhizae, 250 parts of Rhizoma Curcumae, 100 parts of pentoxyverine citrates, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Clinical trial:
Clinical experiment animal is selected the ill dog that 2 monthly ages at monthly age to 5, Laboratory Diagnosed are Infectious Tracheobroncheitis.Experimental dog isolation is raised separately, the complete feedstuff of feeding, and be divided at random 3 groups, and 30 every group, 3 groups of feeding environments are identical, and experimental period is carried out 7 days altogether; Blank group is left intact, and medicine matched group is used treatment by institute's control drug by its description; Present composition group can be by product of the present invention (the prepared compositions of the embodiment of the present invention 1) feeding, and usage and dosage is: this product is waited temperature by per kilogram of body weight 10g～12g and gavaged, every day 2～3 times.After oral, by gastrointestinal absorption, reach the object for the treatment of disease.Computational methods: mortality rate=dead animal number/experimental animal number * 100%, cure rate=healing number of animals/experimental animal number * 100%.Result (testing the 7th day) when following table is experiment end.
Table is the situation contrast of the present invention and other medicines treatment Infectious Tracheobroncheitis:
| Numbering | Group | Mortality rate % | Cure rate % | During end, there is symptom rate % |
| I | Blank group | 40 | 10 | 50 |
| II | The hundstaupe health group of faling apart | 16.7 | 63.3 | 20 |
| III | Present composition group | 6.7 | 76.7 | 16.6 |
Clinical effectiveness statistical analysis, present composition group is compared difference extremely significantly (P<0.01) with the loose group of hundstaupe health.
Safety testing:
Choose 10 of 2 monthly age healthy dogs, wait temperature gavage 10 days according to 5 times of the made compositions recommended dose of the embodiment of the present invention 1, during medication, observation experiment dog is without any bad or Deviant Behavior performance, and the drinking-water of searching for food is normal.
Above-mentioned detailed description of the composition and method of making the same of this treatment Infectious Tracheobroncheitis being carried out with reference to embodiment; illustrative rather than determinate; can list several embodiment according to institute's limited range; therefore in the variation and the modification that do not depart under general plotting of the present invention, within should belonging to protection scope of the present invention.
Claims (3)
1. treat a compositions for infectious bronchitis, it is characterized in that by following component by weight mixed preparing form: propolis 15-35 part, Flos Magnoliae 10-25 part, Radix Paeoniae Alba 10-25 part, Pericarpium Citri Reticulatae 15-25 part, Radix Platycodonis 15-35 part, virazole 10-20 part, doxycycline hydrochloride 5-10 part, Radix Glycyrrhizae 15-35 part, Rhizoma Curcumae 15-25 part, pentoxyverine citrate 5-10 part.
2. the compositions for the treatment of infectious bronchitis according to claim 1, it is characterized in that by following component by weight mixed preparing form: 25 parts of propolis, 15 parts of Flos Magnoliaes, 15 parts of the Radix Paeoniae Albas, 20 parts of Pericarpium Citri Reticulataes, 25 parts of Radix Platycodoniss, 15 parts of virazoles, 7 parts of doxycycline hydrochloride, 25 parts, Radix Glycyrrhizae, 20 parts of Rhizoma Curcumae, 7 parts of pentoxyverine citrates.
3. a preparation method for the compositions for the treatment of Infectious Tracheobroncheitis according to claim 1 and 2, is characterized in that carrying out as follows:
(1) Chinese medicine ingredients in prescription is carried out respectively after micronizing, cross 500 mesh sieves;
(2) take by weight propolis 15-35 part, Flos Magnoliae 10-25 part, Radix Paeoniae Alba 10-25 part, Pericarpium Citri Reticulatae 15-25 part, Radix Platycodonis 15-35 part, mix 5-10 minute to even;
(3) take by weight virazole 10-20 part, doxycycline hydrochloride 5-10 part, Radix Glycyrrhizae 15-35 part, Rhizoma Curcumae 15-25 part, pentoxyverine citrate 5-10 part, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104127533A (en) * | 2014-08-14 | 2014-11-05 | 孙法峰 | Compound bronchitis syrup and preparation method |
Citations (3)
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| CN1557432A (en) * | 2004-02-02 | 2004-12-29 | 四川省仁德制药有限公司 | Preparing process of medicinal composition for treating acute and chronic bronchitis |
| CN101422508A (en) * | 2007-11-02 | 2009-05-06 | 天津瑞普生物技术集团有限公司 | Traditional Chinese medicine oral liquid for treating poultry respiratory tract infection |
| CN102284027A (en) * | 2011-08-18 | 2011-12-21 | 荣成市商贸城卫生所 | Traditional Chinese medicine composition for treating bronchitis |
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- 2013-10-31 CN CN201310547720.5A patent/CN103550705B/en active Active
Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1557432A (en) * | 2004-02-02 | 2004-12-29 | 四川省仁德制药有限公司 | Preparing process of medicinal composition for treating acute and chronic bronchitis |
| CN101422508A (en) * | 2007-11-02 | 2009-05-06 | 天津瑞普生物技术集团有限公司 | Traditional Chinese medicine oral liquid for treating poultry respiratory tract infection |
| CN102284027A (en) * | 2011-08-18 | 2011-12-21 | 荣成市商贸城卫生所 | Traditional Chinese medicine composition for treating bronchitis |
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| 张龙海: "神奇的蜂胶与气管炎及其他", 《东方食疗与保健》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104127533A (en) * | 2014-08-14 | 2014-11-05 | 孙法峰 | Compound bronchitis syrup and preparation method |
| CN104127533B (en) * | 2014-08-14 | 2016-03-30 | 刘颖慧 | Compound recipe bronchitis syrup and preparation method |
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Effective date of registration: 20191223 Address after: 214500 No. 18 Textile Road, Taizhou, Jiangsu, Jingjiang Patentee after: Albert Jiangsu animal health technology limited liability company Address before: 266000 Shandong Province, Qingdao city Licang District Nanwang Industrial Park No. 66 Patentee before: Qingdao Lvman Biological Engineering Co., Ltd. |
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