CN102641474B - Compound propolis composition for treating chicken mycoplasmosis and preparation method thereof - Google Patents
Compound propolis composition for treating chicken mycoplasmosis and preparation method thereof Download PDFInfo
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- CN102641474B CN102641474B CN201210133695.1A CN201210133695A CN102641474B CN 102641474 B CN102641474 B CN 102641474B CN 201210133695 A CN201210133695 A CN 201210133695A CN 102641474 B CN102641474 B CN 102641474B
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Abstract
The invention provides a compound propolis composition for treating chicken mycoplasmosis and a preparation method thereof, which relate to the field of animal medicines. The composition is made by evenly mixing of the following components, parts by weight, 15-35 parts of propolis, 15-30 parts of pericarpium citri reticulatae, 15-30 parts of radix sophorae flavescentis, 15-40 parts of houttuynia cordata, 15-40 parts of scutellaria baicalensis, 15-30 parts of rheum officinale, 15-40 parts of liquorice, 15-40 parts of platycodon grandiflorum, 15-30 parts of rhizoma atractylodis, 15-30 parts of radix curcumae and 15-40 parts of gentiana scabra bunge. The compound propolis composition for treating the chicken mycoplasmosis has the advantages of being reasonable in compound, simple in preparation and free of toxic and side effects, pollution, drug residue, drug resistance, superfine in smashing, high in biological availability and very remarkable in curative effect. Clinic application proves that the compound propolis composition has especially good effects on treating of the chicken mycoplasmosis.
Description
Technical field
The present invention relates to compound bee-glue composition for the treatment of mycoplasma gallinarum disease and preparation method thereof, belong to animal field of medicaments, particularly a kind of compound bee-glue composition for the treatment of mycoplasma gallinarum disease and preparation method thereof.
Background technology
The mycoplasma of chicken be caused by chicken virus mycoplasma age in main infection 4-8 week broiler a kind of epidemic disease, clinical manifestation is breathed rale, cough, stream nose liquid as feature to infect chickling.This disease is poultry one of the principal disease in stage of brooding, and is also typically through one of egg vertical transmission disease, also can pass through number of ways horizontal transmission.The poultry that aviculture is particularly in to the stage of brooding is very harmful.
For this disease, be main mainly with the treatment of antibacterials at present, as fluoroquinolones, aminoglycosides, chloromycetin, Macrolide etc., but the therapeutic effect of its medicine is all outstanding not, again because brood time poultry is still in growth and development stage, Western medicine is very large to its toxic and side effects, has had a strong impact on the healthy growth of poultry, and therefore researching and developing a kind of specific medicament for the treatment of this disease and have no side effect is one of this field scientific research technical staff new problem anxious to be resolved.
Summary of the invention
The object of the invention is to overcome above-mentioned weak point, provide that a kind of reasonable recipe, preparation are simple, successful and have no side effect, effectively treat compound bee-glue composition of mycoplasma gallinarum disease and preparation method thereof.
Implementation of the present invention is as follows for achieving the above object: a kind of compound bee-glue composition for the treatment of mycoplasma gallinarum disease, by following components in weight portion number than being evenly mixed: 15～35 parts of propolis, 15～30 parts of Pericarpium Citri Reticulataes, 15～30 parts of Radix Sophorae Flavescentiss, 15～40 parts of Herba Houttuyniae, 15～40 parts of Radix Scutellariaes, 15～30 parts of Radix Et Rhizoma Rhei, 15～40 parts, Radix Glycyrrhizae, 15～40 parts of Radix Platycodoniss, 15～30 parts of Rhizoma Atractylodis, 15～30 parts of Radix Curcumaes, 15～40 parts of compositions of Radix Gentianae.
Described various component optimum ratio amount is: 25 parts of propolis, 20 parts of Pericarpium Citri Reticulataes, 20 parts of Radix Sophorae Flavescentiss, 30 parts of Herba Houttuyniae, 30 parts of Radix Scutellariaes, 20 parts of Radix Et Rhizoma Rhei, 30 parts, Radix Glycyrrhizae, 30 parts of Radix Platycodoniss, 25 parts of Rhizoma Atractylodis, 25 parts of Radix Curcumaes, 30 parts of compositions of Radix Gentianae.
Treat a preparation method for the compound bee-glue composition of mycoplasma gallinarum disease, carry out as follows:
(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight 15～35 parts of propolis, 15～30 parts of Pericarpium Citri Reticulataes, 15～30 parts of Radix Sophorae Flavescentiss, 15～40 parts of Herba Houttuyniae, 15～40 parts of Radix Scutellariaes, mix 5-10 minute to even;
(3) take by weight 15～30 parts of Radix Et Rhizoma Rhei, 15～40 parts, Radix Glycyrrhizae, 15～40 parts of Radix Platycodoniss, 15～30 parts of Rhizoma Atractylodis, 15～30 parts of Radix Curcumaes, 15～40 parts of Radix Gentianaes, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
The medicinal property of each component is as follows:
Propolis: pungent, bitter, cold, return spleen, stomach warp, there is the functions such as skin moistening granulation promoting, anti-inflammatory analgetic, raising immunity, broad-spectrum antiseptic, promotion Endocrine Activity, regulating plant nervous function.
Pericarpium Citri Reticulatae: bitter, pungent, warm, return lung, spleen channel, there is the function of regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm; Cure mainly poor appetite, stomachache, tripe is swollen, have loose bowels, productive cough due to phlegm-damp etc.
Radix Sophorae Flavescentis: bitter, cold, GUIXIN, liver, stomach, large intestine, urinary bladder channel, have that heat clearing and damp drying, parasite killing go to amass, the function of diuretic; Cure mainly damp-heat dysentery, jaundice, edema, scabies etc.
Herba Houttuyniae: pungent, be slightly cold, return lung meridian, there is the functions such as heat-clearing and toxic substances removing, detumescence and apocenosis, inducing diuresis for treating stranguria syndrome, cure mainly dysentery, intestinal Huang, lung abscess, acute mastitis, stranguria with turbid discharge etc.
Radix Scutellariae: bitter, cold, return lung, gallbladder, spleen, large intestine, small intestine meridian, there is the functions such as heat clearing and damp drying, eliminating fire and detoxication, hemostasis, cure mainly that cough due to lung-heat, gastrointestinal are damp and hot, dysentery, jaundice, high heat are greedyly drunk, have blood in stool, carbuncle sore tumefacting virus etc.
Radix Et Rhizoma Rhei: bitter, cold, return large intestine, spleen, stomach, liver, pericardium channel, there is the function of purging heat and dredging bowels, removing pathogenic heat from blood and toxic substance from the body, removing mass blood stasis expelling; Cure mainly excess-heat constipation, combined symptoms, the yellow furunculosis of skin ulcer, conjunctival congestion and swelling pain, enteritis etc.
Radix Glycyrrhizae: sweet, flat, return lung, the heart, spleen channel, there is invigorating the spleen and replenishing QI, expelling phlegm for arresting cough and middle emergency, removing toxic substances, coordinating the actions of various ingredients in a prescription, cushion toxicity, strong function; Cure mainly weakness of the spleen and stomach, cough with asthma, poisoning etc.
Radix Platycodonis: bitter, pungent, flat, return lung meridian, there is lung qi dispersing, eliminate the phlegm, the function of sore-throat relieving, evacuation of pus; Cure mainly cough with copious phlegm, laryngopharynx swelling and pain, lung abscess etc.
Rhizoma Atractylodis: bitter, pungent, warm, return spleen, stomach, Liver Channel, there is the function of drying damp and strengthening spleen, expelling wind and cold, improving eyesight; Cure mainly have loose bowels, edema, anemofrigid-damp arthralgia, anemofrigid cold, nyctalopia etc.
Radix Curcumae: bitter, acrid, cold, return lung, liver, heart channel, there is the function of promoting QI circulation for relieving depression, removing heat from blood and promoting blood circulation, promoting the function of the gallbladder to alleviate jaundice; Cure mainly that distension and fullness of the chest and abdomen, intestinal Huang are had loose bowels, calentura coma, jaundice due to damp-heat etc.
Radix Gentianae: bitter, cold, return liver, gallbladder meridian, there is eliminating pathogen in the liver gallbladder excess-fire, function except damp-heat in lower-JIAO; Cure mainly jaundice due to damp-heat, conjunctival congestion and swelling pain, eczema pruritus etc.
The action principle that above-mentioned ten a herbs belong to a different category, complements each other, and treating both the principal and secondary aspects of a disease all has the effect of anti-mycoplasma, and has other antibacterial actions concurrently, and limiting proportioning by the present invention, to prepare effect better, can effectively treat mycoplasma gallinarum disease.
The invention has the beneficial effects as follows: reasonable recipe, preparation is simple, and substep mixes more even, has no side effect, curative effect highly significant.The present invention is compound preparation, according to the Chinese veterinarian of motherland traditional theory, optimizes this ten a herb, and makes them according to best proportioning composition compound preparation, and clinical practice proves that treatment mycoplasma gallinarum disease is had to specially good effect.
The specific embodiment
Below in conjunction with preferred embodiment, to according to the specific embodiment provided by the invention, details are as follows:
Embodiment 1
Treat a preparation method for the compound bee-glue composition of mycoplasma gallinarum disease, carry out as follows: (every part by 10g)
(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight 150 parts of propolis, 150 parts of Pericarpium Citri Reticulataes, 150 parts of Radix Sophorae Flavescentiss, 150 parts of Herba Houttuyniae, 150 parts of Radix Scutellariaes, mix 5-10 minute to even;
(3) take by weight 150 parts of Radix Et Rhizoma Rhei, 150 parts, Radix Glycyrrhizae, 150 parts of Radix Platycodoniss, 150 parts of Rhizoma Atractylodis, 150 parts of Radix Curcumaes, 150 parts of Radix Gentianaes, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Embodiment 2
Treat a preparation method for the compound bee-glue composition of mycoplasma gallinarum disease, carry out as follows: (every part by 10g)
(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight 250 parts of propolis, 200 parts of Pericarpium Citri Reticulataes, 200 parts of Radix Sophorae Flavescentiss, 250 parts of Herba Houttuyniae, 250 parts of Radix Scutellariaes, mix 5-10 minute to even;
(3) take by weight 200 parts of Radix Et Rhizoma Rhei, 250 parts, Radix Glycyrrhizae, 250 parts of Radix Platycodoniss, 200 parts of Rhizoma Atractylodis, 250 parts of Radix Curcumaes, 300 parts of Radix Gentianaes, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Embodiment 3
Treat a preparation method for the compound bee-glue composition of mycoplasma gallinarum disease, carry out as follows: (every part by 10g)
(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight 350 parts of propolis, 300 parts of Pericarpium Citri Reticulataes, 300 parts of Radix Sophorae Flavescentiss, 400 parts of Herba Houttuyniae, 400 parts of Radix Scutellariaes, mix 5-10 minute to even;
(3) take by weight 300 parts of Radix Et Rhizoma Rhei, 400 parts, Radix Glycyrrhizae, 400 parts of Radix Platycodoniss, 300 parts of Rhizoma Atractylodis, 300 parts of Radix Curcumaes, 400 parts of Radix Gentianaes, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Clinical trial:
Clinical experiment animal selects 180-240 age in days, body weight at 1.5kg-2.8kg, and Laboratory Diagnosed is the ill laying hen of mycoplasma gallinarum disease.Ill chicken isolation is raised separately, the complete feed of feeding, and be divided at random 3 groups, and 30 every group, 3 groups of feeding environments are identical, and experimental period is carried out 7 days altogether; Blank group is left intact, and medicine matched group uses treatment by institute's control drug by its description; Chinese medicine composition group of the present invention is by product feeding poultry of the present invention etc., and consumption is: this product, by every 100g drinking-water 380Kg or spice 190Kg, 2～3 times on the one, is used in conjunction 3～5 days.After oral, reach the object for the treatment of disease by gastrointestinal absorption.Result (testing the 8th day) when following table is experiment end.
The field applicable cases contrast of the table present composition and other medicines treatment mycoplasma gallinarum disease:
| Numbering | Group | Mortality rate % | Cure rate % | When end, there is symptom rate % |
| I | Blank group | 8.5 | 30.0 | |
| II | Erythromycin thiocyanate group | 5.4 | 78.0 | 16.6 |
| III | Enrofloxacin HCL group | 4.5 | 83.4 | 12.1 |
| IV | Present composition group | 3.8 | 88.4 | 7.8 |
This result of the test statistical analysis, treatment group of the present invention is distinguished difference extremely significantly and significant difference (P < 0.01 and P < 0.05) compared with erythromycin thiocyanate group, Enrofloxacin HCL group.
The above-mentioned detailed description that compound bee-glue composition to this treatment mycoplasma gallinarum disease and preparation method thereof carries out with reference to embodiment; illustrative rather than determinate; can list several embodiment according to institute's limited range; therefore in the variation and the modification that do not depart under general plotting of the present invention, within should belonging to protection scope of the present invention.
Claims (3)
1. treat the compound bee-glue composition of mycoplasma gallinarum disease for one kind, it is characterized in that by following components in weight portion number than being evenly mixed: 15～35 parts of propolis, 15～30 parts of Pericarpium Citri Reticulataes, 15～30 parts of Radix Sophorae Flavescentiss, 15～40 parts of Herba Houttuyniae, 15～40 parts of Radix Scutellariaes, 15～30 parts of Radix Et Rhizoma Rhei, 15～40 parts, Radix Glycyrrhizae, 15～40 parts of Radix Platycodoniss, 15～30 parts of Rhizoma Atractylodis, 15～30 parts of Radix Curcumaes, 15～40 parts of Radix Gentianaes.
2. the compound bee-glue composition for the treatment of mycoplasma gallinarum disease according to claim 1, it is characterized in that by following components in weight portion number than being evenly mixed: 25 parts of propolis, 20 parts of Pericarpium Citri Reticulataes, 20 parts of Radix Sophorae Flavescentiss, 30 parts of Herba Houttuyniae, 30 parts of Radix Scutellariaes, 20 parts of Radix Et Rhizoma Rhei, 30 parts, Radix Glycyrrhizae, 30 parts of Radix Platycodoniss, 25 parts of Rhizoma Atractylodis, 25 parts of Radix Curcumaes, 30 parts of Radix Gentianaes.
3. a preparation method for the compound bee-glue composition for the treatment of mycoplasma gallinarum disease according to claim 1, is characterized in that carrying out as follows:
(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight 15～35 parts of propolis, 15～30 parts of Pericarpium Citri Reticulataes, 15～30 parts of Radix Sophorae Flavescentiss, 15～40 parts of Herba Houttuyniae, 15～40 parts of Radix Scutellariaes, mix 5-10 minute to even;
(3) take by weight 15～30 parts of Radix Et Rhizoma Rhei, 15～40 parts, Radix Glycyrrhizae, 15～40 parts of Radix Platycodoniss, 15～30 parts of Rhizoma Atractylodis, 15～30 parts of Radix Curcumaes, 15～40 parts of Radix Gentianaes, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201210133695.1A CN102641474B (en) | 2012-05-03 | 2012-05-03 | Compound propolis composition for treating chicken mycoplasmosis and preparation method thereof |
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| CN201210133695.1A CN102641474B (en) | 2012-05-03 | 2012-05-03 | Compound propolis composition for treating chicken mycoplasmosis and preparation method thereof |
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| CN102641474B true CN102641474B (en) | 2014-06-18 |
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| CN103599413B (en) * | 2013-11-12 | 2017-01-11 | 青岛众志合才智能科技有限公司 | Traditional Chinese medicine composition for treating mycoplasmosis of chicken and preparation method thereof |
| CN104825625B (en) * | 2015-03-18 | 2017-12-29 | 云南明侍达生物科技有限责任公司 | Antiinflammatory for animals and preparation method thereof |
| CN105998321A (en) * | 2016-05-10 | 2016-10-12 | 烟台东和生态农牧科研所 | Feed additive for treating and preventing broiler mycoplasmosis and preparation method thereof |
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| JP3007665B2 (en) * | 1990-09-18 | 2000-02-07 | 日清製粉株式会社 | Preventive and therapeutic agent for coronavirus infection and disinfectant |
| KR20060093906A (en) * | 2005-02-23 | 2006-08-28 | 주식회사 엘지생활건강 | Anti-influenza viral agent of extract of plant and health supplies containing the same |
| WO2006109898A1 (en) * | 2005-04-09 | 2006-10-19 | Pion-Tech Co., Ltd | Antimicrobial composition containing natural extract, nano silver and natural essential oil |
| CN102258614B (en) * | 2011-07-15 | 2013-09-18 | 青岛绿曼生物工程有限公司 | Compound propolis composition for treating white diarrhea and chronic respiratory disease and preparation method thereof |
| CN102370972B (en) * | 2011-10-12 | 2014-05-07 | 青岛绿曼生物工程有限公司 | Compound Chinese medicine composition for treating infectious bronchitis of chicken and preparation method thereof |
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