CN103479777A - Pure Chinese herbal composition for treating gosling plague and preparation method thereof - Google Patents

Abstract

The invention relates to a pure Chinese herbal composition for treating gosling plague. A preparation method of the pure Chinese herbal composition comprises the following steps: (1) separately grinding all ingredients in a prescription into superfine powders and screening by using a 700 meshes screen; (2) weighing 15-35 parts of Gordon euryale seed, 15-25 parts of schisandra chinensis, 15-35 parts of herba epimedii, 15-25 parts of eleutherococcus senticosus and 15-35 parts of bunge cherry seed, and mixing for 5-10 minutes to be uniform; (3) weighing 10-30 parts of massa medicata fermentata, 10-30 parts of hawthorn, 15-45 parts of fructus psoraleae, 10-35 parts of herba agrimoniae, 15-35 parts of liquorice and 15-25 parts of polygonum cuspidatum, and mixing for 5-10 minutes to be uniform; and (4) mixing the compositions which are prepared in the steps (2) and (3), and continuously mixing for 10-15 minutes to be uniform. The pure Chinese herbal composition is reasonable in composition and simple to prepare, does not have toxic or side effects, medicinal residues or drug resistance, has high bioavailability due to adoption of superfine grinding, and also has an obvious curative effect; moreover, clinical applications prove that the pure Chinese herbal composition has a special curative effect on gosling plague.

Description

Pure Chinese medicine composition for the treatment of gosling plague and preparation method thereof

Technical field

The present invention relates to pure Chinese medicine composition for the treatment of gosling plague and preparation method thereof, belong to the animal field of medicaments, particularly a kind of pure Chinese medicine composition that is specifically designed to the treatment gosling plague and preparation method thereof.

Background technology

Gosling plague is a kind of acute or subacute septic infectious disease caused by Goose Parvovirus, mainly encroaches on 3-20 age in days gosling, take infect fast, sickness rate is high, mortality rate is high, serious dysentery and exudative enteritis are feature.The goose of the various length of time and kind all can infect, and mortality rate generally, between 20%-50%, can affect growth and the egg laying performance of goose.This disease all can occur throughout the year, is one of principal disease of the foster goose industry of harm.

The pathogen of primary disease is Goose Parvovirus, and virus resistance to external world is very strong.This disease almost spreads all over the world all poultry country, is widely distributed.At present, prevent and treat this disease the most frequently used be anti virus herb and Western medicine, Chinese medicine is because its prescription is unreasonable or simple pulverizing the just, particle diameter is excessive, drug release is slower, causes its bioavailability lower, clinical effectiveness is not fine; And various antiviral drugs ban use of as Ministry of Agriculture such as ribavirin, amantadines.

Therefore research and develop that a kind of gosling plague's for the treatment of drug residue free, the generation that has no drug resistance, bioavailability are high, the significant specific medicament of clinical effectiveness is one of this field scientific research technical staff new problem anxious to be resolved.

Summary of the invention

The object of the invention is to overcome above-mentioned weak point, provide that a kind of reasonable recipe, preparation are simple, micronizing, bioavailability are high, successful, have no drug resistance and effective treatment gosling plague's of drug residue pure Chinese medicine composition and preparation method thereof.

For achieving the above object, implementation of the present invention is as follows: a kind of pure Chinese medicine composition for the treatment of gosling plague, by following component by weight mixed preparing form: Semen Euryales 15-35 part, Fructus Schisandrae Chinensis 15-25 part, Cortex Moutan 10-35 part, Herba Epimedii 15-35 part, Radix Et Caulis Acanthopanacis Senticosi 15-25 part, Semen Pruni 15-35 part, Massa Medicata Fermentata 10-30 part, Fructus Crataegi 10-30 part, Fructus Psoraleae 15-45 part, Herba Agrimoniae 10-35 part, Radix Glycyrrhizae 15-35 part, Rhizoma Polygoni Cuspidati 15-25 part.

Described various component optimum ratio amount is: 25 parts of Semen Euryaless, 20 parts of Fructus Schisandrae Chinensis, 25 parts of Cortex Moutans, 25 parts of Herba Epimedii, 20 parts of Radix Et Caulis Acanthopanacis Senticosis, 25 parts of Semen Prunis, 20 parts of Massa Medicata Fermentata, 20 parts of Fructus Crataegis, 30 parts of Fructus Psoraleaes, 25 parts of Herba Agrimoniaes, 25 parts, Radix Glycyrrhizae, 20 parts of Rhizoma Polygoni Cuspidati.

A kind of preparation method for the treatment of gosling plague's pure Chinese medicine composition, carry out as follows:

(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;

(2) take by weight and get Semen Euryales 15-35 part, Fructus Schisandrae Chinensis 15-25 part, Cortex Moutan 10-35 part, Herba Epimedii 15-35 part, Radix Et Caulis Acanthopanacis Senticosi 15-25 part, Semen Pruni 15-35 part, mix 5-10 minute to even;

(3) take by weight Massa Medicata Fermentata 10-30 part, Fructus Crataegi 10-30 part, Fructus Psoraleae 15-45 part, Herba Agrimoniae 10-35 part, Radix Glycyrrhizae 15-35 part, Rhizoma Polygoni Cuspidati 15-25 part, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.

The medicinal property of each component is as follows:

Radix Et Caulis Acanthopanacis Senticosi: acrid, bitter, warm, return kidney, spleen, heart channel, there is the function of replenishing QI to invigorate the spleen, tonifying the kidney for tranquilization; Cure mainly deficiency of both the splenic and pulmonary QI, limbs fatigue, soreness of waist and knee joint, restlessness etc.

Semen Pruni: hot, sweet, bitter, flat, return spleen, large intestine, small intestine meridian, there is the function of loosening bowel to relieve constipation, the therapeutic method to keep the adverse QI flowing downwards, diuretic; Cure mainly dryness of the intestine constipation, the impaction of rumen, edema, ascites etc.

Rhizoma Polygoni Cuspidati: bitter, cold, return gallbladder, liver, lung meridian, there is the function of dampness removing jaundice eliminating, heat-clearing and toxic substances removing, the analgesic therapy of invigorating blood circulation, cough-relieving Zhichuan; Cure mainly jaundice due to damp-heat, puerperal blood stasis, stranguria with turbid discharge, rheumatic arthralgia, carbuncle sore tumefacting virus, cough due to lung-heat, enteritis etc.

Semen Euryales: sweet, puckery, flat, return spleen, kidney channel, there is the function of kidney tonifying arresting seminal emission, spleen reinforcing damp eliminating; Cure mainly spermatorrhea, frequent micturition number, diarrhea due to hypofunction of the spleen, waist arthralgia pain etc.

Fructus Schisandrae Chinensis: sweet, sour, warm, return lung, kidney, heart channel, there is the astringing intestine to stop diarrhea of astringing the lung, the function of the hidroschesis that promotes the production of body fluid, reinforcing the kindey to control nocturnal emission; Cure mainly that the deficiency of the lung is breathed with cough, chronic diarrhea etc.

Cortex Moutan: bitter, hot, be slightly cold, return liver, kidney, heart channel, there is the function of clearing away heat and cooling blood, blood circulation promoting and blood stasis dispelling; Cure mainly that heat enters nutrient blood, epistaxis, has blood in stool, hematuria, carbuncle sore tumefacting virus etc.

Herba Epimedii: hot, sweet, warm, return kidney, Liver Channel, there is the function of kidney-replenishing, bone and muscle strengthening, wind-damp dispelling; Cure mainly that sexual impotence, female animal non-estrus, waist hip are unable, rheumatic arthralgia etc.

Massa Medicata Fermentata: sweet, hot, warm, return stomach, spleen channel, the function that there is invigorating the spleen and regulating the stomach, helps digestion in adjusting; Cure mainly that food stagnation does not disappear, tripe is swollen, postnatal blood stasis stomachache etc.

Fructus Crataegi:: sour, sweet, tepor, return stomach, spleen, Liver Channel, there is the function of promoting digestion and removing stagnation, circulation of qi promoting dissipating blood stasis; Cure mainly dyspeptic abdominal flatulence, dyspepsia, prolonged lochia etc.

Fructus Psoraleae: acrid, bitter, warm, return kidney, spleen channel, there is warming the kidney to invigorate YANG, helping inspiration to relieve asthma, warming spleen and stopping diarrha function; Curing mainly suffers from a deficiency of the kidney coldly lets out, suffers from a deficiency of the kidney and breathe heavily etc.

Herba Agrimoniae: bitter, puckery, flat, return liver, heart channel, there is the function of astringing to arrest bleeding, dysentery relieving, removing toxic substances; Cure mainly have blood in stool, hematuria, haematemesis, epistaxis, dysentery, carbuncle sore tumefacting virus etc.

Radix Glycyrrhizae: sweet, flat, return lung, the heart, spleen channel, there is invigorating the spleen and replenishing QI, expelling phlegm for arresting cough and middle emergency, removing toxic substances, coordinating the actions of various ingredients in a prescription, cushion toxicity, strong function; Cure mainly weakness of the spleen and stomach, cough with asthma, poisoning etc.

Above all flavor Chinese medicine, according to the Chinese medical theory compatible combination, for gosling plague's clinical symptoms and pathological change, is brought into play the effect for the treatment of both the principal and secondary aspects of a disease.

The invention has the beneficial effects as follows: reasonable recipe, preparation is simple, and substep mixes more even; The Chinese medicine composition no drug residue, have no drug resistance, cost is low, draws materials wide, and micronizing, bioavailability are high, can also can drink water by spice, and the curative effect highly significant.The present invention is according to Chinese veterinarian's traditional theory, optimize this 12 flavor Chinese medicine, and make them according to optimum ratio, form pure Chinese powder medicine, clinical practice proves, to treatment, gosling plague has specially good effect, and make its product meat reach nuisanceless requirement, meet the export standard of product, effectively guaranteed that people's is healthy.

The specific embodiment

Below in conjunction with preferred embodiment, to according to the specific embodiment provided by the invention, details are as follows:

Embodiment 1

Pure Chinese medicine composition of a kind of gosling plague for the treatment of and preparation method thereof: carry out as follows: (every part by 10g)

(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;

(2) take by weight and get 150 parts of Semen Euryaless, 150 parts of Fructus Schisandrae Chinensis, 100 parts of Cortex Moutans, 150 parts of Herba Epimedii, 150 parts of Radix Et Caulis Acanthopanacis Senticosis, 150 parts of Semen Prunis, mix 5-10 minute to even;

(3) take by weight 100 parts of Massa Medicata Fermentata, 100 parts of Fructus Crataegis, 150 parts of Fructus Psoraleaes, 100 parts of Herba Agrimoniaes, 150 parts, Radix Glycyrrhizae, 150 parts of Rhizoma Polygoni Cuspidati, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.

Embodiment 2

Pure Chinese medicine composition of a kind of gosling plague for the treatment of and preparation method thereof: carry out as follows: (every part by 10g)

(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;

(2) take by weight and get 250 parts of Semen Euryaless, 200 parts of Fructus Schisandrae Chinensis, 250 parts of Cortex Moutans, 250 parts of Herba Epimedii, 200 parts of Radix Et Caulis Acanthopanacis Senticosis, 250 parts of Semen Prunis, mix 5-10 minute to even;

(3) take by weight 200 parts of Massa Medicata Fermentata, 200 parts of Fructus Crataegis, 300 parts of Fructus Psoraleaes, 250 parts of Herba Agrimoniaes, 250 parts, Radix Glycyrrhizae, 200 parts of Rhizoma Polygoni Cuspidati, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.

Embodiment 3

Pure Chinese medicine composition of a kind of gosling plague for the treatment of and preparation method thereof: carry out as follows: (every part by 10g)

(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;

(2) take by weight and get 350 parts of Semen Euryaless, 250 parts of Fructus Schisandrae Chinensis, 350 parts of Cortex Moutans, 350 parts of Herba Epimedii, 250 parts of Radix Et Caulis Acanthopanacis Senticosis, 350 parts of Semen Prunis, mix 5-10 minute to even;

(3) take by weight 200 parts of Massa Medicata Fermentata, 200 parts of Fructus Crataegis, 300 parts of Fructus Psoraleaes, 250 parts of Herba Agrimoniaes, 250 parts, Radix Glycyrrhizae, 250 parts of Rhizoma Polygoni Cuspidati, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.

Clinical trial:

The clinical experiment animal selects 15 ages in days, body weight at 0.6kg-0.7kg, the ill goose that Laboratory Diagnosed is gosling plague.Ill goose isolation is raised separately, the complete feed of feeding, and be divided at random 3 groups, and 100 every group, 3 groups of feeding environments are identical, and experimental period is carried out 7 days altogether; The blank group is left intact, and the medicine matched group is used treatment by institute's control drug by its description; Present composition group is product of the present invention (the prepared compositions of the embodiment of the present invention 2) the ill goose of feeding, and a day dose is: 300 kilograms are fed or drunk water to 200 kilograms of every 100 gram present composition spices, every day 1-2 time; Reach the purpose for the treatment of disease after oral by gastrointestinal absorption.Computational methods: mortality rate=dead animal number/experimental animal number * 100%, cure rate=healing number of animals/experimental animal number * 100%.Result (testing the 7th day) when following table is the experiment end.

Efficacy assessment standard:

Cure: spirit is normal, and the drinking-water of searching for food is normal, and feces is normal, and bouncing cuts open the histoorgans such as inspection liver, intestinal, fabricius bursa, pancreas normal.

Symptom is arranged during end: clinical symptoms is not improved and is even increased the weight of.

Table is the present invention and other medicines treatment gosling plague's field applicable cases contrast:

Numbering	Group	Mortality rate %	Cure rate %	Symptom rate % is arranged during end
					I	The blank group	33	11	56
II	Gosling plague's group of faling apart	17	67	16
					III	Present composition group	10	79	11

This clinical effectiveness statistical analysis, present composition group is being compared difference extremely significantly (P<0.01) with the loose group of gosling plague aspect cure rate.

Safety testing:

Choose 60 of the healthy geese of 10 ages in days, according to 5 times of spices of the made pure Chinese medicine composition recommended dose of the embodiment of the present invention 2 or drink water 5 days, during medication, healthy goose is without any bad or Deviant Behavior performance, the drinking-water of searching for food is normal, and body weight increases that to compare difference not remarkable with blank group (being not administration of health group).

Above-mentioned detailed description of pure Chinese medicine composition of this treatment gosling plague and preparation method thereof being carried out with reference to embodiment; illustrative rather than determinate; can list several embodiment according to institute's limited range; therefore in the variation and the modification that do not break away under general plotting of the present invention, within should belonging to protection scope of the present invention.

Claims (3)

1. a pure Chinese medicine composition for the treatment of gosling plague, it is characterized in that by following component by weight mixed preparing form: Semen Euryales 15-35 part, Fructus Schisandrae Chinensis 15-25 part, Cortex Moutan 10-35 part, Herba Epimedii 15-35 part, Radix Et Caulis Acanthopanacis Senticosi 15-25 part, Semen Pruni 15-35 part, Massa Medicata Fermentata 10-30 part, Fructus Crataegi 10-30 part, Fructus Psoraleae 15-45 part, Herba Agrimoniae 10-35 part, Radix Glycyrrhizae 15-35 part, Rhizoma Polygoni Cuspidati 15-25 part.

2. treatment gosling plague's according to claim 1 pure Chinese medicine composition, is characterized in that described various component optimum ratio amount is: 25 parts of Semen Euryaless, 20 parts of Fructus Schisandrae Chinensis, 25 parts of Cortex Moutans, 25 parts of Herba Epimedii, 20 parts of Radix Et Caulis Acanthopanacis Senticosis, 25 parts of Semen Prunis, 20 parts of Massa Medicata Fermentata, 20 parts of Fructus Crataegis, 30 parts of Fructus Psoraleaes, 25 parts of Herba Agrimoniaes, 25 parts, Radix Glycyrrhizae, 20 parts of Rhizoma Polygoni Cuspidati.

3. the preparation method of pure Chinese medicine composition of the treatment according to claim 1 gosling plague is characterized in that carrying out as follows:

(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;

(2) take by weight and get Semen Euryales 15-35 part, Fructus Schisandrae Chinensis 15-25 part, Cortex Moutan 10-35 part, Herba Epimedii 15-35 part, Radix Et Caulis Acanthopanacis Senticosi 15-25 part, Semen Pruni 15-35 part, mix 5-10 minute to even;

(3) take by weight Massa Medicata Fermentata 10-30 part, Fructus Crataegi 10-30 part, Fructus Psoraleae 15-45 part, Herba Agrimoniae 10-35 part, Radix Glycyrrhizae 15-35 part, Rhizoma Polygoni Cuspidati 15-25 part, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.