CN102258614B - Compound propolis composition for treating white diarrhea and chronic respiratory disease and preparation method thereof - Google Patents
Compound propolis composition for treating white diarrhea and chronic respiratory disease and preparation method thereof Download PDFInfo
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- CN102258614B CN102258614B CN2011101982530A CN201110198253A CN102258614B CN 102258614 B CN102258614 B CN 102258614B CN 2011101982530 A CN2011101982530 A CN 2011101982530A CN 201110198253 A CN201110198253 A CN 201110198253A CN 102258614 B CN102258614 B CN 102258614B
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Abstract
The invention relates to a compound propolis composition for treating white diarrhea and chronic respiratory disease and a preparation method thereof. The preparation method is characterized comprising the following steps: weighing 10-15 parts by weight of propolis ethanol extract, 5-10 parts by weight of herba andrographitis aqueous extract, 5-10 parts by weight of licorice root aqueous extract and 10-20 parts by weight of anhydrous glucose, and stirring and mixing for 5-10 minutes; taking 5-10 parts of taraxacum aqueous extract, 5-10 parts of herba houttuyniae aqueous extract, 5-10 parts ofBaikal skullcap root aqueous extract, 5-10 parts of phellodendron bark aqueous extract and 10-30 parts of anhydrous glucose, and stirring and mixing for 5-10 minutes; and merging the two mixtures, adding the rest of anhydrous glucose, stirring for 10-20 minutes, and evenly mixing to obtain the compound propolis composition for treating white diarrhea and chronic respiratory disease. The inventionhas the advantages of reasonable formula, simple preparation process, no toxic or side effect and no medicine residue; and the clinical application proves that the compound propolis composition has especially good effect for treating white diarrhea and chronic respiratory disease.
Description
Technical field
The present invention relates to fowl medicine field, particularly a kind of compound bee-glue composition for the treatment of Pullorum Disease and chronic respiratory tract disease and preparation method thereof.
Background technology
The Pullorum Disease of poultry is sick by a kind of popular outburst of the chickling in the salmonellal main harm 2-3 of Pullorum Disease age in week, and the chickling mortality rate can be up to 100%, and it is feature that clinical manifestation is arranged white pasty state loose stool with chickling.Chronic respiratory disease of fowl (CRD) is a kind of epidemic disease of the main infection 4-8 broiler in age in week that caused by chicken virus mycoplasma, and to breathe rale, cough, stream nose liquid be feature to infect chickling in clinical manifestation.These two kinds of diseases are poultry one of the principal disease in stage of brooding, and also are typically through one of egg vertical transmission disease, also can pass through the number of ways horizontal transmission.The poultry that aviculture particularly is in the stage of brooding is very harmful.
For these two kinds of diseases, many treatments based on antibacterials at present, as fluoroquinolones, aminoglycosides, chloromycetin, Macrolide etc., but the therapeutic effect of its medicine is all outstanding inadequately, still be in growth and development stage because of the brood time poultry again, Western medicine is very big to its toxic and side effects, has had a strong impact on the healthy growth of poultry, and therefore researching and developing a kind of specific medicament for the treatment of these two kinds of diseases and having no side effect is one of this field scientific research technical staff new problem anxious to be solved.
Summary of the invention
The objective of the invention is to overcome above-mentioned weak point, provide that a kind of reasonable recipe, preparation are simple, effect obviously and have no side effect, effectively treat compound bee-glue composition of Pullorum Disease and chronic respiratory tract disease and preparation method thereof.
Implementation of the present invention is as follows for achieving the above object: a kind of compound bee-glue composition for the treatment of Pullorum Disease and chronic respiratory tract disease, it is characterized in that by following components in weight portion number than evenly being mixed and made into: 10～15 parts of propolis ethanol extract, 5～10 parts of Herba Andrographis water extracts, 5～10 parts of Herba Taraxaci water extracts, 5～10 parts of Herba Houttuyniae water extracts, 5～10 parts of Radix Scutellariae water extracts, 5～10 parts of Cortex Phellodendri water extracts, 5～10 parts of Radix Glycyrrhizae water extracts, 25～60 parts of compositions of anhydrous glucose.
Described various component optimum ratio amount is: 12 parts of propolis ethanol extract, 7 parts of Herba Andrographis water extracts, 7 parts of Herba Taraxaci water extracts, 8 parts of Herba Houttuyniae water extracts, 8 parts of Radix Scutellariae water extracts, 8 parts of Cortex Phellodendri water extracts, 10 parts of Radix Glycyrrhizae water extracts, 40 parts of anhydrous glucose.
A kind of preparation method for the treatment of the compound bee-glue composition of Pullorum Disease and chronic respiratory tract disease is characterized in that carrying out as follows:
(1) takes by weighing 10～15 parts of propolis ethanol extract, 5～10 parts of Herba Andrographis water extracts, 5～10 parts of Radix Glycyrrhizae water extracts, 10～20 parts of anhydrous glucose by weight, mixed 5～10 minutes;
(2) get 5～10 parts of Herba Taraxaci water extracts, 5～10 parts of Herba Houttuyniae water extracts, 5～10 parts of Radix Scutellariae water extracts, 5～10 parts of Cortex Phellodendri water extracts, 10～30 parts of anhydrous glucose mixed 5～10 minutes;
(3) after the compositions that combining step (1) and (2) make, add anhydrous glucose surplus part, stirred 10～20 minutes, mix homogeneously.
The medicinal property of each component is as follows:
Propolis: hot, bitter, cold, return spleen, stomach warp, have functions such as skin moistening granulation promoting, anti-inflammatory analgetic, raising immunity, broad-spectrum antiseptic, the activity of promotion endocrine, adjusting vegetative nerve function.
Herba Andrographis: bitter, cold, GUIXIN, lung, large intestine, urinary bladder channel have functions such as heat-clearing and toxic substances removing, reducing swelling and alleviating pain, cure mainly cold, fever, damp-heat diarrhea, carbuncle sore furunculosis etc.
Herba Taraxaci: bitter, sweet, cold, return liver, stomach warp, have functions such as heat-clearing and toxic substances removing, dispersing swelling and dissipating binds, inducing diuresis for treating stranguria syndrome, cure mainly jaundice due to damp-heat, pyretic stranguria, acute mastitis, lung abscess, pharyngalgia, sore etc.
Herba Houttuyniae: hot, be slightly cold, return lung meridian, have functions such as heat-clearing and toxic substances removing, detumescence and apocenosis, inducing diuresis for treating stranguria syndrome, cure mainly dysentery, intestinal Huang, lung abscess, acute mastitis, stranguria with turbid discharge etc.
Radix Scutellariae: bitter, cold, return lung, gallbladder, spleen, large intestine, small intestine meridian, have functions such as heat clearing and damp drying, eliminating fire and detoxication, hemostasis, cure mainly that cough due to lung-heat, gastrointestinal are damp and hot, dysentery, jaundice, hyperpyrexia are greedyly drunk, have blood in stool, carbuncle sore tumefacting virus etc.
Cortex Phellodendri: bitter, cold, return kidney, urinary bladder channel, have functions such as heat clearing and damp drying, eliminating fire and detoxication, reducing the asthenic fever, cure mainly jaundice, damp and hot dysentery, pyretic stranguria, the eczema etc. of letting out.
Radix Glycyrrhizae: sweet, flat, return lung, the heart, spleen channel, have invigorating the spleen and replenishing QI, expelling phlegm for arresting cough and middle emergency, detoxifcation, coordinating the actions of various ingredients in a prescription, cushion toxicity, strong function; Cure mainly weakness of the spleen and stomach, cough with asthma, poisoning etc.
The action principle that above-mentioned seven flavor Chinese medicines belong to a different category, Radix Scutellariae, Cortex Phellodendri, Herba Andrographis, Herba Houttuyniae are heat clearing and dampness removing medicine, Herba Taraxaci is heat and toxic materials clearing away medicine, propolis, Radix Glycyrrhizae are Qi-tonifying drug, and the three complements each other, treating both the principal and secondary aspects of a disease, the effect that all has anti-salmonella and mycoplasma, and have other antibacterial actions concurrently, limiting proportioning by the present invention, to prepare effect better, can effectively treat Pullorum Disease and chronic respiratory tract disease.
The invention has the beneficial effects as follows: reasonable recipe, preparation is simple, and substep mixes more even, has no side effect the curative effect highly significant.The present invention is compound preparation, according to the Chinese veterinarian of motherland traditional theory, optimizes this seven flavors Chinese medicine, and makes them form compound preparation according to best proportioning, and clinical practice proves that treatment Pullorum Disease and chronic respiratory tract disease are had specially good effect.
The specific embodiment
Below in conjunction with preferred embodiment, to details are as follows according to the specific embodiment provided by the invention:
Embodiment 1
A kind of preparation method for the treatment of the compound bee-glue composition of Pullorum Disease and chronic respiratory tract disease is characterized in that carrying out as follows: (every part by 10g)
(1) takes by weighing 100 parts of propolis ethanol extract, 50 parts of Herba Andrographis water extracts, 50 parts of Radix Glycyrrhizae water extracts, 200 parts of anhydrous glucose by weight, mixed 5～10 minutes;
(2) get 50 parts of Herba Taraxaci water extracts, 50 parts of Herba Houttuyniae water extracts, 50 parts of Radix Scutellariae water extracts, 50 parts of Cortex Phellodendri water extracts, 200 parts of anhydrous glucose mixed 5～10 minutes;
(3) after the compositions that combining step (1) and (2) make, add anhydrous glucose surplus part, namely add 200 parts, stirred 10～20 minutes, mix homogeneously.
Embodiment 2
A kind of preparation method for the treatment of the compound bee-glue composition of Pullorum Disease and chronic respiratory tract disease is characterized in that carrying out as follows: (every part by 10g)
(1) takes by weighing 120 parts of propolis ethanol extract, 70 parts of Herba Andrographis water extracts, 70 parts of Radix Glycyrrhizae water extracts, 150 parts of anhydrous glucose by weight, mixed 5～10 minutes;
(2) get 80 parts of Herba Taraxaci water extracts, 80 parts of Herba Houttuyniae water extracts, 80 parts of Radix Scutellariae water extracts, 70 parts of Cortex Phellodendri water extracts, 200 parts of anhydrous glucose mixed 5～10 minutes;
(3) after the compositions that combining step (1) and (2) make, add anhydrous glucose surplus part, namely add 80 parts, stirred 10～20 minutes, mix homogeneously.
Embodiment 3
A kind of preparation method for the treatment of the compound bee-glue composition of Pullorum Disease and chronic respiratory tract disease is characterized in that carrying out as follows: (every part by 10g)
(1) takes by weighing 150 parts of propolis ethanol extract, 100 parts of Herba Andrographis water extracts, 100 parts of Radix Glycyrrhizae water extracts, 100 parts of anhydrous glucose by weight, mixed 5～10 minutes;
(2) get 100 parts of Herba Taraxaci water extracts, 100 parts of Herba Houttuyniae water extracts, 100 parts of Radix Scutellariae water extracts, 100 parts of Cortex Phellodendri water extracts, 100 parts of anhydrous glucose mixed 5～10 minutes;
(3) after the compositions that combining step (1) and (2) make, add anhydrous glucose surplus part, namely add 50 parts, stirred 10～20 minutes, mix homogeneously.
Clinical trial:
With product feeding poultry of the present invention etc., consumption is: this product 2～3 times on the one, is used in conjunction 3～5 days by every 100g drinking-water 400Kg or spice 200Kg.Oral back reaches the purpose for the treatment of disease by gastrointestinal absorption.
The field applicable cases contrast of table 1 present composition and other medicines treatment Pullorum Disease:
| Numbering | Group | Mortality rate % | Cure rate % | Symptom rate % is arranged during end |
| Ⅰ | The blank group | 14.4 | - | 21.5 |
| Ⅱ | The kanamycin sulfate group | 7.4 | 82.0 | 10.6 |
| Ⅲ | The ciprofloxacin group | 8.5 | 81.4 | 11.1 |
| Ⅳ | Of the present invention group | 4.0 | 91.9 | 4.1 |
This result of the test is analyzed by statistics, and treatment group of the present invention is compared difference extremely significantly (P＜0.01) with kanamycin sulfate group, ciprofloxacin group.
The field applicable cases contrast of table 2 present composition and other medicines treatment chronic respiratory tract disease:
| Numbering | Group | Mortality rate % | Cure rate % | Symptom rate % is arranged during end |
| Ⅰ | The blank group | 8.5 | - | 30.0 |
| Ⅱ | The erythromycin thiocyanate group | 5.4 | 78.0 | 16.6 |
| Ⅲ | The Enrofloxacin HCL group | 4.5 | 83.4 | 12.1 |
| Ⅳ | Of the present invention group | 3.2 | 89.7 | 7.1 |
This result of the test is analyzed by statistics, and treatment group of the present invention is compared the extremely remarkable and significant difference (P＜0.01, P＜0.05) of difference respectively with erythromycin thiocyanate group, Enrofloxacin HCL group.
Above-mentioned detailed description of compound bee-glue composition of this treatment Pullorum Disease and chronic respiratory tract disease and preparation method thereof being carried out with reference to embodiment; be illustrative rather than determinate; can list several embodiment according to institute's limited range; therefore in the variation and the modification that do not break away under the general plotting of the present invention, should belong within protection scope of the present invention.
Claims (3)
1. compound bee-glue composition for the treatment of Pullorum Disease and chronic respiratory tract disease, it is characterized in that by following components in weight portion number than evenly being mixed and made into: 10～15 parts of propolis ethanol extract, 5～10 parts of Herba Andrographis water extracts, 5～10 parts of Herba Taraxaci water extracts, 5～10 parts of Herba Houttuyniae water extracts, 5～10 parts of Radix Scutellariae water extracts, 5～10 parts of Cortex Phellodendri water extracts, 5～10 parts of Radix Glycyrrhizae water extracts, 25～60 parts of compositions of anhydrous glucose.
2. the compound bee-glue composition for the treatment of Pullorum Disease according to claim 1 and chronic respiratory tract disease, it is characterized in that described various component optimum ratio amount is: 12 parts of propolis ethanol extract, 7 parts of Herba Andrographis water extracts, 7 parts of Herba Taraxaci water extracts, 8 parts of Herba Houttuyniae water extracts, 8 parts of Radix Scutellariae water extracts, 8 parts of Cortex Phellodendri water extracts, 10 parts of Radix Glycyrrhizae water extracts, 40 parts of anhydrous glucose.
3. the preparation method of the compound bee-glue composition of a treatment Pullorum Disease according to claim 1 and 2 and chronic respiratory tract disease is characterized in that carrying out as follows:
(1) takes by weighing 10～15 parts of propolis ethanol extract, 5～10 parts of Herba Andrographis water extracts, 5～10 parts of Radix Glycyrrhizae water extracts, 10～20 parts of anhydrous glucose by weight, mixed 5～10 minutes;
(2) get 5～10 parts of Herba Taraxaci water extracts, 5～10 parts of Herba Houttuyniae water extracts, 5～10 parts of Radix Scutellariae water extracts, 5～10 parts of Cortex Phellodendri water extracts, 10～30 parts of anhydrous glucose mixed 5～10 minutes;
(3) after the compositions that combining step (1) and step (2) make, add anhydrous glucose surplus part, stirred 10～20 minutes, mix homogeneously.
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Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN102600457B (en) * | 2011-12-22 | 2013-12-04 | 青岛绿曼生物工程有限公司 | Compound propolis composition used for treating pig viral diarrhea and preparation method thereof |
| CN102641474B (en) * | 2012-05-03 | 2014-06-18 | 青岛绿曼生物工程有限公司 | Compound propolis composition for treating chicken mycoplasmosis and preparation method thereof |
| CN102813809B (en) * | 2012-08-02 | 2014-07-30 | 青岛绿曼生物工程有限公司 | Pure traditional Chinese medicine composition for treating chronic respiratory disease of poultry as well as preparation method thereof |
| DK2908831T3 (en) * | 2012-10-17 | 2018-03-12 | Montero Gida Sanayi Ve Ticaret As | HERBAL FORMULATIONS |
| EP2908834B1 (en) * | 2012-10-17 | 2017-07-12 | Montero Gida Sanayi Ve Ticaret A.S. | New formulations comprising plant extracts |
| CN103877229B (en) * | 2013-05-10 | 2016-06-08 | 武汉市畜牧兽医科学研究所 | A kind of compound Chinese medicine extract and application thereof preventing and treating an avian colibacillosis |
| CN103356793B (en) * | 2013-07-25 | 2014-08-13 | 恒盛高科（天津）生物技术有限公司 | Traditional Chinese medicinal composition for controlling ostrich salmonellosis, and preparation method thereof |
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| 中草药在鸡病防治上的应用研究;施仁波;《中兽医医药杂志》;20070430(第2期);第68-70页 * |
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