CN104208213B - A kind of Chinese-western medicine preparation treating chicken coccidiosis and preparation method thereof - Google Patents
A kind of Chinese-western medicine preparation treating chicken coccidiosis and preparation method thereof Download PDFInfo
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Abstract
The invention discloses a kind of Chinese-western medicine preparation treating chicken coccidiosis and preparation method thereof, raw material by following weight portion: Radix Dichroae 60 80 parts, Fructus Quisqualis 60 80 parts, Radix Et Rhizoma Rhei 40 60 parts, Radix Sanguisorbae 20 40 parts, Radix Angelicae Sinensis 20 40 parts, 10 20 parts of Radix Glycyrrhizae, make clear paste, then according to clear paste: the ratio of diclazuril mass ratio 5 10:1 adds diclazuril, it is uniformly mixed so as to obtain mixture, in mixture in mixture: cane sugar powder, the ratio of beta cyclodextrin mass ratio 1:3:1 add cane sugar powder and beta cyclodextrin, mixing, is drying to obtain.Chinese medicine composition and diclazuril are compounded by the present invention, use Chinese and Western compound recipe therapy for treating chicken coccidiosis, achieve the effect of highly significant, effectively strengthen the curative effect of medicine, particularly sudden chicken coccidiosis are had good curative effect.The present invention is Chinese-western medicine preparation simultaneously, decreases Western medicine consumption, thus decreases drug residue.
Description
Technical field
The present invention relates to a kind of Chinese-western medicine preparation treating chicken coccidiosis, also relate to the preparation method of this Chinese-western medicine preparation, belong to
In veterinary drug technical field.
Background technology
Chicken coccidiosis is a kind of global Protozool diseases, the most only mortality rate of 30%～70%, the most also has a strong impact on life
Produce performance.Owing to development and the application of vaccine to chicken coccidiosis remain and do not have been resolved at many critical problems, therefore medical treatment is still
It it is so the Main Means tackling chicken coccidiosis.But averagely consuming anticoccidial expense with every plumage broiler is 0.2～0.3 yuan of calculating, I
National expenditures will reach 6～1,800,000,000 RMB in chicken anticoccidial expense.And life-time service Western medicine preventing and treating, exist polypide be easily generated drug resistance,
The shortcomings such as poisonous side effect of medicine is big, meat egg drug residue amount is high.Herbal control chicken coccidiosis has shown that good at present
The impetus, the use of Chinese herbal medicine both can effectively prevent and treat coccidiosis, fundamentally improves the immunity of chicken, eliminates after chicken infects coccidiosis and produces
The symptoms such as the dysentery of life, hemafecia, the problem also solving the problem that broiler residue of veterinary drug, there is good development prospect.But herbal medicine efficacy
Relatively slow, when the state of an illness is more serious, generally requires and use the mode of Integrated TCM to control chicken coccidiosis.
Summary of the invention
It is an object of the invention to provide a kind of Chinese-western medicine preparation treating chicken coccidiosis, it is possible to effectively treat chicken coccidiosis.
The present invention also aims to provide the preparation method of a kind of Chinese-western medicine preparation treating chicken coccidiosis.
In order to realize object above, the technical solution adopted in the present invention is to provide a kind of Chinese-western medicine preparation treating chicken coccidiosis,
Raw material by following weight portion: Radix Dichroae 60-80 part, Fructus Quisqualis 60-80 part, Radix Et Rhizoma Rhei 40-60 part, Radix Sanguisorbae 20-40 part, Radix Angelicae Sinensis
20-40 part, Radix Glycyrrhizae 10-20 part, make clear paste, then according to clear paste: the ratio of diclazuril mass ratio 5-10:1 adds ground gram
Pearl profit, is uniformly mixed so as to obtain mixture, in mixture in mixture: cane sugar powder, the ratio of beta-schardinger dextrin-mass ratio 1:3:1 add sugarcane
Icing Sugar and beta-schardinger dextrin-, mixing, it is drying to obtain.
Preferably, the Chinese-western medicine preparation of described treatment chicken coccidiosis, by the raw material of following weight portion: Radix Dichroae 80 parts, Fructus Quisqualis
80 parts, Radix Et Rhizoma Rhei 60 parts, Radix Sanguisorbae 40 parts, Radix Angelicae Sinensis 40 parts, 20 parts of Radix Glycyrrhizae, make clear paste, then according to clear paste: ground gram pearl
The ratio of profit mass ratio 5-10:1 adds diclazuril, is uniformly mixed so as to obtain mixture, presses mixture in mixture: cane sugar powder, β-
The ratio of cyclodextrin mass ratio 1:3:1 adds cane sugar powder and beta-schardinger dextrin-, mixing, is drying to obtain.
The effect of each Chinese medicine in the present invention:
Radix Dichroae, bitter, acrid, cold, mild toxicity.Return liver, spleen channel.Preventing the attack (or recurrence) of malaria, robs expectorant.Cure mainly malaria, in the heart phlegm retention accumulation.Containing often
Bergseife, halofuginone hydrobromide etc., wherein halofuginone hydrobromide has the strongest killing action to coccidiosis.
Fructus Quisqualis, sweet, temperature, mild toxicity.Return spleen, stomach warp.Parasite killing, removing food stagnancy, spleen invigorating.Cure mainly abdominal pain due to worm stagnation, infantile malnutrition,
Breast food is stagnated, dysentery.
Radix Et Rhizoma Rhei, bitter, cold.Return stomach, large intestine, liver, spleen channel.Attack stagnant, clearing away damp-heat, pathogenic fire purging, removing heat from blood, blood stasis dispelling, removing toxic substances.
Cure mainly solid cubic content constipation, the accumulation of heat feeling of stuffiness in chest；Damp-heat dysentery, jaundice, gonorrhea, edema abdominal distention, dysuria；Conjunctival congestion, laryngopharynx swelling and pain,
Aphtha of the mouth and tongue, gastropyretic vomiting；Spit blood, spitting of blood, epistaxis, have blood in stool, hematuria；Blood-retention.
Radix Sanguisorbae, bitter, sour, it is slightly cold.Return liver, stomach, large intestine channel.Cooling blood for hemostasis, heat-clearing and toxic substances removing.Cure mainly haematemesis, spit blood, be defeated in battle
Blood, hematuria, have blood in stool, hemorrhoidal bleeding, dysentery.
Radix Angelicae Sinensis, sweet, pungent, bitter, temperature.Return liver, the heart, spleen channel.Replenishing and activating blood, menstruction regulating and pain relieving, moisturize laxation.Cure mainly blood deficiency
All cards, dryness of the intestine dyschezia, weight, ulcer sores, injury from falling down after bloody dysentery.
Radix Glycyrrhizae, sweet, flat.Return spleen, stomach, the heart, lung meridian.With middle emergency, lung moistening, removing toxic substances, coordinating the actions of various ingredients in a prescription.Process with controlling taste
Weak；Raw with controlling laryngopharynx swelling and pain, swollen ulcer drug, infantile carbuncle, and medicine, alimentary toxicosis.
The present invention is under the guidance of the dialectical theoretical method of defensive-qi-nutrient-blood of Chinese veterinarian, by all medicines of principle compatibility of monarch, to kill
The Radix Dichroae of worm anthelmintic, Fructus Quisqualis are principal agent, with heat and toxic materials clearing away, promote coccidiosis to discharge, the Radix Et Rhizoma Rhei of heat-clearing and toxic substances removing as accessory drugs, with cool
Blood hemostasis, benefiting blood and regulating blood circulation, the Radix Sanguisorbae of convergence removing toxic substances, Radix Angelicae Sinensis etc. are adjuvant drug, to have invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, only to eliminate the phlegm
Cough and the Radix Glycyrrhizae of the effect such as coordinating the actions of various ingredients in a prescription is for making medicine, the Chinese medicine composition of the preventing and treating coccidiosis of the composition present invention.Diclazuril belongs to
Triazine benzene acetonitrile compound, for novel, efficient, low toxicity anticoccidial drug, is widely used in anti-chicken coccidiosis.The present invention is by Chinese drug-treated group
Compound and diclazuril compound, and use Chinese and Western compound recipe therapy for treating chicken coccidiosis, achieve the effect of highly significant, effectively
Strengthen the curative effect of medicine, particularly sudden chicken coccidiosis is had good curative effect.The present invention is Chinese-western medicine preparation simultaneously, subtracts
Lack Western medicine consumption, thus decrease drug residue.
The technical solution adopted in the present invention also resides in the preparation method providing a kind of Chinese-western medicine preparation treating chicken coccidiosis, including
Following steps:
(1) weigh each Chinese medicine by weight, add the water retting 1 hour of 15 times of Chinese medicine gross masses, then decoct 2 hours, mistake
Filter, after filter, residue repeats to decoct 1 time, merging filtrate, and evaporation and concentration filtrate to relative density is 1.10-1.20；
(2) adding equal-volume 95% ethanol in the concentrated solution that step (1) prepares, after mixing, 4 DEG C of cold preservations stand overnight, and return
Receive ethanol, prepare medicinal liquid, 4 DEG C of cold preservations, filter, filtrate is concentrated into relative density and is 1.35-1.38(80 DEG C) clear paste；
(3) according to clear paste in clear paste: the ratio of diclazuril mass ratio 5-10:1 adds diclazuril, is uniformly mixed so as to obtain mixture,
In mixture in mixture: cane sugar powder, the ratio of beta-schardinger dextrin-mass ratio 1:3:1 add cane sugar powder and beta-schardinger dextrin-, mix,
It is drying to obtain.
The preparation method of the present invention is simple and convenient to operate, it is easy to industrialization promotion.
Detailed description of the invention
Embodiment 1
The Chinese-western medicine preparation of the treatment chicken coccidiosis of the present embodiment, by the raw material of following weight portion: Radix Dichroae 80 parts, Fructus Quisqualis 80
Part, Radix Et Rhizoma Rhei 60 parts, Radix Sanguisorbae 40 parts, Radix Angelicae Sinensis 40 parts, 20 parts of Radix Glycyrrhizae, make clear paste, then according to clear paste: diclazuril
The ratio of mass ratio 5:1 adds diclazuril, is uniformly mixed so as to obtain mixture, presses mixture in mixture: cane sugar powder, beta-schardinger dextrin-
The ratio of mass ratio 1:3:1 adds cane sugar powder and beta-schardinger dextrin-, mixing, is drying to obtain.
The preparation method of the Chinese-western medicine preparation of the treatment chicken coccidiosis of the present embodiment, comprises the following steps:
(1) weigh each Chinese medicine by weight, add the water retting 1 hour of 15 times of Chinese medicine gross masses, then decoct 2 hours, mistake
Filter, after filter, residue repeats to decoct 1 time, merging filtrate, and evaporation and concentration filtrate to relative density is 1.20；
(2) adding equal-volume 95% ethanol in the concentrated solution that step (1) prepares, after mixing, 4 DEG C of cold preservations stand overnight, and return
Receive ethanol, prepare medicinal liquid, 4 DEG C of cold preservations, filter, filtrate is concentrated into relative density and is 1.38(80 DEG C) clear paste；
(3) according to clear paste in clear paste: the ratio of diclazuril mass ratio 5:1 adds diclazuril, is uniformly mixed so as to obtain mixture,
In mixture in mixture: cane sugar powder, the ratio of beta-schardinger dextrin-mass ratio 1:3:1 add cane sugar powder and beta-schardinger dextrin-, mix,
It is drying to obtain.
Embodiment 2
The Chinese-western medicine preparation of the treatment chicken coccidiosis of the present embodiment, by the raw material of following weight portion: Radix Dichroae 60 parts, Fructus Quisqualis 70
Part, Radix Et Rhizoma Rhei 40 parts, Radix Sanguisorbae 30 parts, Radix Angelicae Sinensis 20 parts, 15 parts of Radix Glycyrrhizae, make clear paste, then according to clear paste: diclazuril
The ratio of mass ratio 8:1 adds diclazuril, is uniformly mixed so as to obtain mixture, presses mixture in mixture: cane sugar powder, beta-schardinger dextrin-
The ratio of mass ratio 1:3:1 adds cane sugar powder and beta-schardinger dextrin-, mixing, is drying to obtain.
The preparation method of the Chinese-western medicine preparation of the treatment chicken coccidiosis of the present embodiment, comprises the following steps:
(1) weigh each Chinese medicine by weight, add the water retting 1 hour of 15 times of Chinese medicine gross masses, then decoct 2 hours, mistake
Filter, after filter, residue repeats to decoct 1 time, merging filtrate, and evaporation and concentration filtrate to relative density is 1.10；
(2) adding equal-volume 95% ethanol in the concentrated solution that step (1) prepares, after mixing, 4 DEG C of cold preservations stand overnight, and return
Receive ethanol, prepare medicinal liquid, 4 DEG C of cold preservations, filter, filtrate is concentrated into relative density and is 1.35(80 DEG C) clear paste；
(3) according to clear paste in clear paste: the ratio of diclazuril mass ratio 8:1 adds diclazuril, is uniformly mixed so as to obtain mixture,
In mixture in mixture: cane sugar powder, the ratio of beta-schardinger dextrin-mass ratio 1:3:1 add cane sugar powder and beta-schardinger dextrin-, mix,
It is drying to obtain.
Embodiment 3
The Chinese-western medicine preparation of the treatment chicken coccidiosis of the present embodiment, by the raw material of following weight portion: Radix Dichroae 70 parts, Fructus Quisqualis 60
Part, Radix Et Rhizoma Rhei 50 parts, Radix Sanguisorbae 20 parts, Radix Angelicae Sinensis 30 parts, 10 parts of Radix Glycyrrhizae, make clear paste, then according to clear paste: diclazuril
The ratio of mass ratio 10:1 adds diclazuril, is uniformly mixed so as to obtain mixture, presses mixture: cane sugar powder, β-ring is stuck with paste in mixture
The extract Iuality ratio than 1:3:1 adds cane sugar powder and beta-schardinger dextrin-, mixing, is drying to obtain.
The preparation method of the Chinese-western medicine preparation of the treatment chicken coccidiosis of the present embodiment, comprises the following steps:
(1) weigh each Chinese medicine by weight, add the water retting 1 hour of 15 times of Chinese medicine gross masses, then decoct 2 hours, mistake
Filter, after filter, residue repeats to decoct 1 time, merging filtrate, and evaporation and concentration filtrate to relative density is 1.15；
(2) adding equal-volume 95% ethanol in the concentrated solution that step (1) prepares, after mixing, 4 DEG C of cold preservations stand overnight, and return
Receive ethanol, prepare medicinal liquid, 4 DEG C of cold preservations, filter, filtrate is concentrated into relative density and is 1.36(80 DEG C) clear paste；
(3) according to clear paste in clear paste: the ratio of diclazuril mass ratio 10:1 adds diclazuril, is uniformly mixed so as to obtain mixture,
In mixture in mixture: cane sugar powder, the ratio of beta-schardinger dextrin-mass ratio 1:3:1 add cane sugar powder and beta-schardinger dextrin-, mix,
It is drying to obtain.
Experimental example 1
Normal diet used by this experimental example is commercially available conventional feed.
Laboratory animal: certain chicken house 1 age in days Roman egghen chickling, raises in the laboratory of strict sterilization, feeds without coccidiosis medicine
Dorking granular feed, drink clean tap water.Raising to 10 ages in days, stool examination determines that non-ball worm infects.
Experiment packet and process: experimental chicken is in 11 ages in days by numbering of only weighing on an empty stomach, and therefrom selected part chickling peroral infection is tender
Eimeria Sporulated Oocysts 6 × 104Individual/only, select the infected chicken 40 having obvious disease symptom, be randomly divided into 4 groups, often
Organizing 10, the 1st, 2,3 groups are respectively the high dose group of embodiment 1 Chinese-western medicine preparation, middle dosage group, low dose group, and the 4th
Group is for infecting matched group, and feeding normal diet, the healthy chick 10 that alternative is uninfected by, feeding normal diet, as blank right
According to group (the 5th group), concrete processing mode is shown in Table 1.The spirit of daily check chicken, appetite and feces situation of change, after infection 8
It end is weighed, is cutd open and kill, and observes caecum lesion and scores, and takes cecal content mixing homogenate, measures gram egg capsule by Maxwell counting method
Number (OPG), the results are shown in Table 2.
Table 1 experiment packet and process
Table 2 anticoccidial experimental result
| Group | Survival rate (%) | Caecum lesion value | Body weight increase rate (%) | Egg capsule value | ACI |
| 1 | 100 | 0 | 96 | 1 | 195 |
| 2 | 100 | 1 | 85 | 1 | 183 |
| 3 | 100 | 2 | 81 | 3 | 176 |
| 4 | 80 | 32 | 42 | 53 | 47 |
| 5 | 100 | 0 | 98 | 0 | 198 |
Note: body weight increase rate (%)=Chinese-western medicine preparation high (in, low) dosage group or infect matched group average weight gain/blank group
Average weight gain × 100%.
Survival rate (%)=(total chicken number in survival number of elements/group in group) × 100%.
Lesion score and pathological changes value: by Johnson and Reid(1970) standard formulated carries out evaluation to caecum lesion and scores.
Average lesion scores × 10 in pathological changes value=group.Way of specifically scoring is: when both sides caecum lesion is inconsistent, with serious one
Side is as the criterion.0 point, without naked eyes pathological changes；+ 1 point, caecum wall has the blood stasis point that minimal amount is dispersed in, and it is normal that intestinal wall does not thicken content；
+ 2 points, pathological changes quantity is more, and cecal content obvious band blood, caecum wall thickening, content is normal；+ 3 points, cecal content
Volume blood or have caecum core (blood clot or canescence caseous Banana Type block), caecum wall is plump substantially, excrement in caecum
Just content is few；+ 4 points, because being full of a large amount of blood or intestinal core and caecum enlargement, containing excrement slag or without excrement slag in intestinal core.Dead chicken
The most also note+4 points.
Egg capsule value: by the method for angle Tian Qing, cecal content gram egg sac number (OPG) is scaled egg capsule value, i.e. every gram feces
In egg sac number] when OPG value is 0-0.1, egg capsule value is 0, when OPG value is 0.11-1.0, egg capsule value is 1, when
When OPG value is 1.1-1.9, egg capsule value is 10, and when OPG value is 2.0-5.9, egg capsule value is 20, when OPG value is 6.0-10.9
Time, egg capsule value is 30, and when OPG value >=11.0, egg capsule value is 40.
According to above four indices, calculate ACI by the computing formula of Merck company.ACI=(body weight increase rate+survival rate)
-(pathological changes value+egg capsule value).Drug effect criterion is: ACI person more than 180 is efficient；180～160 is middle effect；160～
120 is poor efficiency；Less than 120 persons are invalid.
Table 2 result shows: Chinese medicine and western medicine of the present invention direct high dose group effect is best, and body weight increase rate is 96%.Anticoccidial index
(ACI) it is 195, for efficiently.Middle dosage group, low dose group effect are taken second place, and body weight increase rate is respectively 85%, 81%, anti-
Coccidiosis index is respectively 183, and 176, all substantially exceed the relative weight gain 42% and the anticoccidial index 47 infecting matched group.
Experimental example 2
Normal diet used by this experimental example is commercially available conventional feed.
Laboratory animal: certain chicken house 1 age in days Roman egghen chickling, raises in the laboratory of strict sterilization, feeds without coccidiosis medicine
Dorking granular feed, drink clean tap water.Raising to 10 ages in days, stool examination determines that non-ball worm infects.
Experiment packet and process: experimental chicken is in 11 ages in days by numbering of only weighing on an empty stomach, and therefrom selected part chickling peroral infection is tender
Eimeria Sporulated Oocysts 6 × 104Individual/only, select the infected chicken 50 having obvious disease symptom, be randomly divided into 5 groups, often
Organize 10, the 1st, 2,3 groups of test group being respectively embodiment 1-3 Chinese-western medicine preparation, addition 2% makes an addition in drinking-water,
4th group is diclazuril matched group, diclazuril consumption be the Chinese medicine composition in Chinese-western medicine preparation and diclazuril consumption it
With, make an addition in drinking-water, the 5th group for infecting matched group, the healthy chick 10 that is uninfected by of alternative, as blank group (the
6 groups).Below often organize chicken equal feeding normal diet, the spirit of daily check chicken, appetite and feces situation of change, infect latter 8 days
End is weighed, is cutd open and kill, and observes caecum lesion and scores, and takes cecal content mixing homogenate, measures gram egg sac number by Maxwell counting method
(OPG), the results are shown in Table 3.
Table 3 anticoccidial experimental result
| Group | Survival rate (%) | Caecum lesion value | Body weight increase rate (%) | Egg capsule value | ACI |
| 1 | 100 | 0 | 96 | 1 | 195 |
| 2 | 98 | 1 | 91 | 3 | 185 |
| 3 | 95 | 1 | 91 | 4 | 181 |
| 4 | 95 | 2 | 96 | 1 | 188 |
| 5 | 80 | 32 | 42 | 53 | 47 |
| 6 | 100 | 0 | 98 | 0 | 198 |
Table 3 result shows: by Chinese medicine composition and diclazuril with the use of, anti-chicken coccidiosis effect is notable, wherein embodiment
1 best results；Simultaneously the present invention by Chinese medicine composition and diclazuril with the use of, reduce the consumption of diclazuril, thus
Decrease drug residue.
Claims (2)
1. the Chinese-western medicine preparation treating chicken coccidiosis, it is characterized in that, raw material by following weight portion: Radix Dichroae 60-80 part, Fructus Quisqualis 60-80 part, Radix Et Rhizoma Rhei 40-60 part, Radix Sanguisorbae 20-40 part, Radix Angelicae Sinensis 20-40 part, Radix Glycyrrhizae 10-20 part, make clear paste, then according to clear paste: the ratio of diclazuril mass ratio 5-10:1 adds diclazuril, it is uniformly mixed so as to obtain mixture, in mixture, presses mixture: cane sugar powder
: the ratio of beta-schardinger dextrin-mass ratio 1:3:1 adds cane sugar powder and beta-schardinger dextrin-, mixing, is drying to obtain
,
The preparation method of the Chinese-western medicine preparation of described treatment chicken coccidiosis, comprises the following steps:
(1) weighing each Chinese medicine by weight, add the water retting 1 hour of 15 times of Chinese medicine gross masses, then decoct 2 hours, filter, after filter, residue repeats to decoct 1 time, merging filtrate, and evaporation and concentration filtrate to relative density is 1.10-1.20；
(2) adding equal-volume 95% ethanol in the concentrated solution that step (1) prepares, after mixing, 4 DEG C of cold preservations stand overnight, and reclaim ethanol, prepare medicinal liquid, 4 DEG C of cold preservations, filter, and filtrate is concentrated into the clear paste that relative density is 1.35-1.38；
(3) according to clear paste in clear paste: the ratio of diclazuril mass ratio 5-10:1 adds diclazuril, is uniformly mixed so as to obtain mixture, in mixture, mixture is pressed: cane sugar powder
: the ratio of beta-schardinger dextrin-mass ratio 1:3:1 adds cane sugar powder and beta-schardinger dextrin-, mixing, is drying to obtain.
The Chinese-western medicine preparation for the treatment of chicken coccidiosis the most according to claim 1, it is characterized in that, raw material by following weight portion: Radix Dichroae 80 parts, Fructus Quisqualis 80 parts, Radix Et Rhizoma Rhei 60 parts, Radix Sanguisorbae 40 parts, Radix Angelicae Sinensis 40 parts, 20 parts of Radix Glycyrrhizae, make clear paste, then according to clear paste: the ratio of diclazuril mass ratio 5-10:1 adds diclazuril, it is uniformly mixed so as to obtain mixture, in mixture in mixture: cane sugar powder: the ratio of beta-schardinger dextrin-mass ratio 1:3:1 adds cane sugar powder and beta-schardinger dextrin-, mixing, is drying to obtain.
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| 中药抗柔嫩艾美尔球虫机制研究;马海利等，;《中国预防兽医学报》;20010131;第23卷(第1期);第33-35页 * |
| 中西药合用防治鸡球虫病试验;白喜婷等，;《河南科技大学学报（农学版）》;20040331;第24卷(第1期);第17-19页 * |
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Address after: 451162 Henan Zhengzhou Zhengzhou airport comprehensive economic experimentation area, Xingang Avenue East Patentee after: Henan Hou Yi Industry Group Co., Ltd. Address before: 451162 east of Xingang Avenue, Zhengzhou air port, Zhengzhou, Henan Patentee before: Zhengzhou Houyi Pharmaceutical Co., Ltd. |
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Effective date of registration: 20211221 Address after: 463000 Zhumadian Industrial Park, Henan Province Patentee after: HENAN HOUYI PHARMACY CO.,LTD. Address before: 451162 Henan Zhengzhou Zhengzhou airport comprehensive economic experimentation area, Xingang Avenue East Patentee before: HENAN HOUYI INDUSTRIAL GROUP CO.,LTD. |