CN103055002A - Composition for treating respiratory disease of poultry and preparation method thereof - Google Patents
Composition for treating respiratory disease of poultry and preparation method thereof Download PDFInfo
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- CN103055002A CN103055002A CN2012105491335A CN201210549133A CN103055002A CN 103055002 A CN103055002 A CN 103055002A CN 2012105491335 A CN2012105491335 A CN 2012105491335A CN 201210549133 A CN201210549133 A CN 201210549133A CN 103055002 A CN103055002 A CN 103055002A
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Abstract
The invention relates to a composition for treating respiratory disease of poultry and a preparation method thereof. The composition is prepared by mixing the following components in part by weight: 10 to 20 parts of doxycycline hydrochloride, 15 to 45 parts of liquoric root, 15 to 35 parts of platycodon root, 25 to 35 parts of borneol and 25 to 45 parts of heartleaf houttuynia herb. The composition has the advantages that the composition is reasonable in formula and easy to prepare, treats both symptoms and root causes, and has a very obvious curative effect; Chinese medicines and western medicines are combined; and the clinical results prove that the composition has a special effect of treating respiratory disease of the poultry.
Description
Technical field
The present invention relates to a kind of composition and method of making the same for the treatment of poultry respiratory tract diseases, belong to the animal field of medicaments, particularly a kind of composition and method of making the same that is specifically designed to the treatment poultry respiratory tract diseases.
Background technology
Poultry respiratory tract diseases mainly is a kind of common epidemic disease that is caused by mycoplasma, antibacterial, virus etc., and clinical manifestation is breathed rale, cough, stream nose liquid as feature to infect poultry; Pathological change is mainly manifested in trachea and bronchus has serosity or mucus exudate, airsacculitis, pericarditis, perihepatitis etc.But this disease is horizontal transmission both, also can be through the egg vertical transmission, and the poultry that aviculture particularly is in the stage of brooding is very harmful.
At present, treat this disease Western medicine and mainly use antimicrobial drug and antiviral agents, in a single day antimicrobial drug produces drug resistance, and this disease is difficult to treatment; And the antiviral agents Ministry of Agriculture has abrogated use.Chinese medicine is because powder particle diameter is larger, and bioavailability is low, and onset is slower, and effect is not very desirable.
Therefore researching and developing the medicine that a kind of Chinese medicine and western medicine effectively treats poultry respiratory tract diseases in conjunction with, treating both the principal and secondary aspects of a disease is one of this field scientific research technical staff new problem anxious to be resolved.
Summary of the invention
The object of the invention is to overcome above-mentioned weak point, provide that a kind of reasonable recipe, preparation are simple, Chinese medicine and western medicine is in conjunction with, treating both the principal and secondary aspects of a disease, effectively treats the composition and method of making the same of poultry respiratory tract diseases.
Implementation of the present invention is as follows for achieving the above object: a kind of compositions for the treatment of poultry respiratory tract diseases, by following component by weight mixed preparing form: doxycycline hydrochloride 10-20 part, Radix Glycyrrhizae 15-45 part, Radix Platycodonis 15-35 part, Borneolum Syntheticum 25-35 part, Herba Houttuyniae 25-45 part.
On the basis of such scheme, described various component optimum ratio amounts are: 15 parts of doxycycline hydrochloride, 30 parts in Radix Glycyrrhizae, 25 parts of Radix Platycodoniss, 30 parts of Borneolum Syntheticums, 35 parts of Herba Houttuyniae.
A kind of preparation method for the treatment of the compositions of poultry respiratory tract diseases, carry out as follows:
(1) Chinese medicines such as the Radix Glycyrrhizae in the prescription, Radix Platycodonis, Borneolum Syntheticum, Herba Houttuyniae is carried out respectively cross 700 mesh sieves after the micronizing;
(2) take by weighing by weight doxycycline hydrochloride 10-20 part, Radix Glycyrrhizae 15-45 part, mix 5-10 minute to even;
(3) take by weighing by weight Radix Platycodonis 15-35 part, Borneolum Syntheticum 25-35 part, Herba Houttuyniae 25-45 part, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
The medicinal property of each component is as follows:
Doxycycline hydrochloride: be faint yellow or yellow crystalline powder, odorless, bitter in the mouth.Be a kind of tetracycline antibiotics of high-efficiency broad spectrum, oral absorption is good.Be mainly used in responsive gram positive bacteria and the respiratory tract infection due to the gram negative bacilli, mycoplasma pneumonia etc.Main side effects shows as nausea,vomiting,diarrhea etc.
Radix Glycyrrhizae: sweet, flat, return lung, the heart, spleen channel, have invigorating the spleen and replenishing QI, expelling phlegm for arresting cough and middle emergency, detoxifcation, coordinating the actions of various ingredients in a prescription, cushion toxicity, strong function; Cure mainly weakness of the spleen and stomach, cough with asthma, poisoning.
Radix Platycodonis: bitter, hot, flat, return lung meridian, have lung qi dispersing, eliminate the phlegm, the function of sore-throat relieving, evacuation of pus; Cure mainly cough with copious phlegm, laryngopharynx swelling and pain, lung abscess etc.
Borneolum Syntheticum: hot, bitter, cold, GUIXIN, spleen, lung meridian have the function of sensible refreshment, heat-clearing and fire-dispersing, reducing swelling and alleviating pain; Cure mainly coma convulsions, laryngopharynx swelling and pain, heat in the heart tongue boil, conjunctival congestion cataracta, sore swollen toxin etc.
Herba Houttuyniae: hot, be slightly cold, return lung meridian, have the functions such as heat-clearing and toxic substances removing, detumescence and apocenosis, inducing diuresis for treating stranguria syndrome, cure mainly dysentery, intestinal Huang, lung abscess, acute mastitis, stranguria with turbid discharge etc.
More than all herbal medicines according to the theoretical compatible combination of medicine, for paathogenic factor and the pathological change of poultry respiratory tract diseases, the effect of performance treating both the principal and secondary aspects of a disease.
The invention has the beneficial effects as follows: reasonable recipe, preparation is simple, and substep mixes more even; Chinese medicine and western medicine combination, treating both the principal and secondary aspects of a disease.The clinical practice proof has specially good effect to the treatment poultry respiratory tract diseases.
The specific embodiment
Below in conjunction with preferred embodiment, to details are as follows according to the specific embodiment provided by the invention:
Embodiment 1
A kind of composition and method of making the same for the treatment of poultry respiratory tract diseases: carry out as follows: (every part by 10g)
(1) Chinese medicines such as the Radix Glycyrrhizae in the prescription, Radix Platycodonis, Borneolum Syntheticum, Herba Houttuyniae is carried out respectively cross 700 mesh sieves after the micronizing;
(2) take by weighing by weight 100 parts of doxycycline hydrochloride, 150 parts in Radix Glycyrrhizae, mix 5-10 minute to even;
(3) take by weighing by weight 150 parts of Radix Platycodoniss, 250 parts of Borneolum Syntheticums, 250 parts of Herba Houttuyniae, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Embodiment 2
A kind of composition and method of making the same for the treatment of poultry respiratory tract diseases: carry out as follows: (every part by 10g)
(1) Chinese medicines such as the Radix Glycyrrhizae in the prescription, Radix Platycodonis, Borneolum Syntheticum, Herba Houttuyniae is carried out respectively cross 700 mesh sieves after the micronizing;
(2) take by weighing by weight 150 parts of doxycycline hydrochloride, 300 parts in Radix Glycyrrhizae, mix 5-10 minute to even;
(3) take by weighing by weight 250 parts of Radix Platycodoniss, 300 parts of Borneolum Syntheticums, 350 parts of Herba Houttuyniae, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Embodiment 3
A kind of composition and method of making the same for the treatment of poultry respiratory tract diseases: carry out as follows: (every part by 10g)
(1) Chinese medicines such as the Radix Glycyrrhizae in the prescription, Radix Platycodonis, Borneolum Syntheticum, Herba Houttuyniae is carried out respectively cross 700 mesh sieves after the micronizing;
(2) take by weighing by weight 200 parts of doxycycline hydrochloride, 450 parts in Radix Glycyrrhizae, mix 5-10 minute to even;
(3) take by weighing by weight 350 parts of Radix Platycodoniss, 350 parts of Borneolum Syntheticums, 450 parts of Herba Houttuyniae, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Clinical trial:
The clinical experiment animal selects 20 ages in days, body weight at 1.0kg-1.1kg, and Laboratory Diagnosed is the ill broiler of chronic respiratory disease.Ill chicken isolation is raised separately, the complete feed of feeding, and be divided at random 3 groups, and 100 every group, 3 groups of feeding environments are identical, and experimental period was carried out 5 days altogether; The blank group is left intact, and the medicine matched group uses treatment with institute's control drug by its description; Present composition group is with product of the present invention (embodiment of the invention 1 prepared compositions) the ill broiler of feeding, and a day dose is: per 100 restrain 250 kilograms of present composition spices feeds or drinks water 450 kilograms, every day 1-2 time; Reach the purpose for the treatment of disease after oral by gastrointestinal absorption.Computational methods: mortality rate=dead animal number/experimental animal number * 100%, cure rate=healing number of animals/experimental animal number * 100%.Result's (testing the 5th day) when following table is the experiment end.
Table is the field applicable cases contrast of the present invention and other medicines treatment chicken respiratory tract disease:
| Numbering | Group | Mortality rate % | Cure rate % | Symptom rate % is arranged during end |
| I | The blank group | 8.0 | 62.0 | 30.0 |
| II | The erythromycin thiocyanate group | 5.0 | 79.0 | 16.0 |
| III | Present composition group | 3.0 | 89.0 | 8.0 |
This clinical effectiveness statistical analysis, present composition group is being compared difference extremely significantly (P＜0.01) with the erythromycin thiocyanate group aspect the cure rate.
Safety testing:
Choose 60 of 20 age in days healthy AA broiler, according to 5 times of spices of the embodiment of the invention 1 made compositions recommended dose or drank water 5 days, during the medication, healthy chicken is without any bad or Deviant Behavior performance, the drinking-water of searching for food is normal, and body weight increases that to compare difference not remarkable with blank group (being not administration of health group).
Above-mentioned detailed description of the composition and method of making the same of this treatment poultry respiratory tract diseases being carried out with reference to embodiment; illustrative rather than determinate; can list several embodiment according to institute's limited range; therefore in the variation and the modification that do not break away under the general plotting of the present invention, should belong within protection scope of the present invention.
Claims (3)
1. compositions for the treatment of poultry respiratory tract diseases, it is characterized in that by following component by weight mixed preparing form: doxycycline hydrochloride 10-20 part, Radix Glycyrrhizae 15-45 part, Radix Platycodonis 15-35 part, Borneolum Syntheticum 25-35 part, Herba Houttuyniae 25-45 part.
2. the compositions for the treatment of poultry respiratory tract diseases according to claim 1, it is characterized in that by following component by weight mixed preparing form: 15 parts of doxycycline hydrochloride, 30 parts in Radix Glycyrrhizae, 25 parts of Radix Platycodoniss, 30 parts of Borneolum Syntheticums, 35 parts of Herba Houttuyniae.
3. the preparation method of the compositions of a treatment poultry respiratory tract diseases according to claim 1 and 2 is characterized in that carrying out as follows:
(1) Chinese medicines such as the Radix Glycyrrhizae in the prescription, Radix Platycodonis, Borneolum Syntheticum, Herba Houttuyniae is carried out respectively cross 700 mesh sieves after the micronizing;
(2) take by weighing by weight doxycycline hydrochloride 10-20 part, Radix Glycyrrhizae 15-45 part, mix 5-10 minute to even;
(3) take by weighing by weight Radix Platycodonis 15-35 part, Borneolum Syntheticum 25-35 part, Herba Houttuyniae 25-45 part, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
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| Application Number | Priority Date | Filing Date | Title |
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| CN2012105491335A CN103055002A (en) | 2012-12-05 | 2012-12-05 | Composition for treating respiratory disease of poultry and preparation method thereof |
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| CN2012105491335A CN103055002A (en) | 2012-12-05 | 2012-12-05 | Composition for treating respiratory disease of poultry and preparation method thereof |
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| CN103055002A true CN103055002A (en) | 2013-04-24 |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105770138A (en) * | 2014-12-16 | 2016-07-20 | 洛阳惠中兽药有限公司 | Composition, preparation method and application thereof |
| CN106955325A (en) * | 2016-01-11 | 2017-07-18 | 天津嘉创生物科技有限公司 | Treat Chinese and Western medicine compound mixture of broiler chicken chronic respiratory and preparation method thereof |
Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101804062A (en) * | 2010-04-23 | 2010-08-18 | 镇江威特药业有限责任公司 | Long-acting veterinary compound doxycycline injection and preparation method thereof |
-
2012
- 2012-12-05 CN CN2012105491335A patent/CN103055002A/en active Pending
Patent Citations (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101804062A (en) * | 2010-04-23 | 2010-08-18 | 镇江威特药业有限责任公司 | Long-acting veterinary compound doxycycline injection and preparation method thereof |
Non-Patent Citations (2)
| Title |
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| 877762436Q: "鱼腥草", 《HTTP://BAIKE.BAIDU.COM/HISTORY/ID=37117922》 * |
| 郭耀武等: "冰片伪品及掺伪品的鉴别", 《时珍国医国药》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105770138A (en) * | 2014-12-16 | 2016-07-20 | 洛阳惠中兽药有限公司 | Composition, preparation method and application thereof |
| CN106955325A (en) * | 2016-01-11 | 2017-07-18 | 天津嘉创生物科技有限公司 | Treat Chinese and Western medicine compound mixture of broiler chicken chronic respiratory and preparation method thereof |
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Application publication date: 20130424 |