CN103550705B - The composition and method of making the same for the treatment of Infectious Tracheobroncheitis - Google Patents
The composition and method of making the same for the treatment of Infectious Tracheobroncheitis Download PDFInfo
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- PTNZGHXUZDHMIQ-CVHRZJFOSA-N (4S,4aR,5S,5aR,6R,12aR)-4-(dimethylamino)-1,5,10,11,12a-pentahydroxy-6-methyl-3,12-dioxo-4a,5,5a,6-tetrahydro-4H-tetracene-2-carboxamide;hydrochloride Chemical compound Cl.C1=CC=C2[C@H](C)[C@@H]([C@H](O)[C@@H]3[C@](C(O)=C(C(N)=O)C(=O)[C@H]3N(C)C)(O)C3=O)C3=C(O)C2=C1O PTNZGHXUZDHMIQ-CVHRZJFOSA-N 0.000 claims abstract description 11
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Abstract
The present invention relates to a kind of compositions for the treatment of Infectious Tracheobroncheitis, its preparation method carries out as follows: (1) crosses 500 mesh sieves after the Chinese medicine ingredients in prescription being carried out respectively micronizing; (2) take propolis 15-35 part, Flos Magnoliae 10-25 part, Radix Paeoniae Alba 10-25 part, Pericarpium Citri Reticulatae 15-25 part, Radix Platycodonis 15-35 part by weight, mix 5-10 minute to even; (3) take virazole 10-20 part, doxycycline hydrochloride 5-10 part, Radix Glycyrrhizae 15-35 part, Rhizoma Curcumae 15-25 part, pentoxyverine citrate 5-10 part by weight, mix 5-10 minute to even; (4) merge the compositions that above-mentioned (2), (3) step are obtained, continue mixing 10-15 minute to even.The invention has the beneficial effects as follows: reasonable recipe, preparation is simple; Preparation technology adopts advanced superfine communication technique, drastically increases the bioavailability of effective ingredient; Integrated TCM, treating both the principal and secondary aspects of a disease.Clinical proof has specially good effect to treatment Infectious Tracheobroncheitis, and application prospect is boundless.
Description
Technical field
The present invention relates to the composition and method of making the same for the treatment of Infectious Tracheobroncheitis, particularly a kind of composition and method of making the same being specifically designed to treatment Infectious Tracheobroncheitis.
Background technology
Infectious bronchitis is commonly referred to dog and coughs or disease coughed by dog nest, have break out, sudden cough, irregularly spit, a kind of hyperinfection respiratory tract disease of the feature such as eye nasal discharge.Be mainly a kind of Chronic exposure sexually transmitted disease that II type hepatitis infectiosa canis virus causes, mainly present laryngitis, tracheitis, bronchitis, tonsillitis and symptoms of pneumonia, can other bacterial diseasees of secondary infection etc.The dog of all ages and classes, sex, kind all can infect, and mortality rate is very high, is that one of main epidemic disease of dog industry is supported in harm.
Current medicine effect is outstanding not, and therefore researching and developing a kind of specific medicament for the treatment of Infectious Tracheobroncheitis is one of this field scientific research technical staff new problem anxious to be resolved.
Summary of the invention
The object of the invention is to overcome above-mentioned weak point, a kind of reasonable recipe is provided, prepare simple, successful, effectively treatment Infectious Tracheobroncheitis composition and method of making the same.
Implementation of the present invention is as follows for achieving the above object: a kind of compositions for the treatment of Infectious Tracheobroncheitis, by following component by weight mixed preparing form: propolis 15-35 part, Flos Magnoliae 10-25 part, Radix Paeoniae Alba 10-25 part, Pericarpium Citri Reticulatae 15-25 part, Radix Platycodonis 15-35 part, virazole 1020 parts, doxycycline hydrochloride 5-10 part, Radix Glycyrrhizae 15-35 part, Rhizoma Curcumae 15-25 part, pentoxyverine citrate 5-10 part.
Described various component optimum ratio amount is: propolis 25 parts, Flos Magnoliae 15 parts, the Radix Paeoniae Alba 15 parts, Pericarpium Citri Reticulatae 20 parts, Radix Platycodonis 25 parts, virazole 15 parts, doxycycline hydrochloride 7 parts, 25 parts, Radix Glycyrrhizae, Rhizoma Curcumae 20 parts, pentoxyverine citrate 7 parts.
Treat a preparation method for the compositions of Infectious Tracheobroncheitis, carry out as follows:
(1) 500 mesh sieves are crossed after the Chinese medicine ingredients in prescription being carried out respectively micronizing;
(2) take propolis 15-35 part, Flos Magnoliae 10-25 part, Radix Paeoniae Alba 10-25 part, Pericarpium Citri Reticulatae 15-25 part, Radix Platycodonis 15-35 part by weight, mix 5-10 minute to even;
(3) take virazole 10-20 part, doxycycline hydrochloride 5-10 part, Radix Glycyrrhizae 15-35 part, Rhizoma Curcumae 15-25 part, pentoxyverine citrate 5-10 part by weight, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step are obtained, continue mixing 10-15 minute to even.
The medicinal property of each component is as follows:
Propolis: bitter, acrid, cold, returns spleen, stomach warp, have anti-inflammation, pain relieving only overworked, promote tissue regeneration, improve immunity, antiallergic oxidation, hemostasis, protection gastrointestinal mucosa function etc.
Flos Magnoliae: pungent, warm, attaches to the lung and stomach meridians, and has the function of dispersing wind and cold, clearing the nasal passage; Cure mainly wind and cold nasal obstruction, brain forehead nose pus etc.
The Radix Paeoniae Alba: bitter, acid, to be slightly cold, returns liver, spleen channel, has suppressing the hyperactive liver pain relieving, the function of the yin fluid astringing that nourishes blood; Cure mainly deficiecny of liver-YIN, deficiency-heat, dysentery stomachache, spasm of the limbs etc.
Pericarpium Citri Reticulatae: bitter, pungent, warm, returns lung, spleen channel, has the function of regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm; Cure mainly poor appetite, stomachache, tripe be swollen, have loose bowels, productive cough due to phlegm-damp etc.
Radix Platycodonis: bitter, pungent, flat, returns lung meridian, there is lung qi dispersing, eliminate the phlegm, sore-throat relieving, evacuation of pus function; Cure mainly cough with copious phlegm, laryngopharynx swelling and pain, lung abscess etc.
Radix Glycyrrhizae: sweet, flat, returns lung, the heart, spleen channel, has invigorating the spleen and replenishing QI, expelling phlegm for arresting cough and middle emergency, removing toxic substances, coordinating the actions of various ingredients in a prescription, cushion toxicity, strong function; Cure mainly weakness of the spleen and stomach, cough with asthma, poisoning etc.
Virazole: white crystalline powder, is the antiviral drugs of broad spectrum high-effect, is widely used in the control of viral disease at present.
Doxycycline hydrochloride: be faint yellow or yellow crystalline powder, tetracycline antibiotics.The mechanism of action is the synthesis of interference bacterioprotein, and oral absorption is good.Be mainly used in responsive gram positive bacteria and gram negative bacilli and the infection caused by mycoplasma.
Rhizoma Curcumae: acrid, bitter, warm, returns liver, spleen channel, has the function of broken silt removing food stagnancy, promoting the circulation of QI to relieve pain; Cure mainly stagnation of QI-blood, tripe abdominal distention and pain, accumulation of food in the stomach and intes tine due to indigestion, traumatic injury etc.
Wei Lin is dragged in citric acid spray: white crystalline powder is antitussive class medicine, for the cough that a variety of causes causes.The mechanism of action is to the selective inhibitory action of coughing centre, still has slight atropine-like effect and local anesthetic action, and heavy dose of have spasmolysis to bronchial smooth muscle, therefore it has central and peripheral antitussive effect concurrently.
All herbal medicines are for the various factors causing Infectious Tracheobroncheitis above, play the comprehensive function for the treatment of both the principal and secondary aspects of a disease.
The invention has the beneficial effects as follows: reasonable recipe, preparation is simple, and substep mixing is more even; Integrated TCM, treating both the principal and secondary aspects of a disease; And making them form said composition according to optimum ratio, clinical practice proves, has specially good effect to treatment Infectious Tracheobroncheitis.
Detailed description of the invention
Below in conjunction with preferred embodiment, to according to detailed description of the invention provided by the invention, details are as follows:
Embodiment 1
A kind of composition and method of making the same for the treatment of Infectious Tracheobroncheitis: carry out as follows: (every part by 10g)
(1) 500 mesh sieves are crossed after the Chinese medicine ingredients in prescription being carried out respectively micronizing;
(2) take propolis 150 parts, Flos Magnoliae 100 parts, the Radix Paeoniae Alba 100 parts, Pericarpium Citri Reticulatae 150 parts, Radix Platycodonis 150 parts by weight, mix 5-10 minute to even;
(3) take virazole 100 parts, doxycycline hydrochloride 50 parts, 150 parts, Radix Glycyrrhizae, Rhizoma Curcumae 150 parts, pentoxyverine citrate 50 parts by weight, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step are obtained, continue mixing 10-15 minute to even.
Embodiment 2
A kind of composition and method of making the same for the treatment of Infectious Tracheobroncheitis: carry out as follows: (every part by 10g)
(1) 500 mesh sieves are crossed after the Chinese medicine ingredients in prescription being carried out respectively micronizing;
(2) take propolis 250 parts, Flos Magnoliae 150 parts, the Radix Paeoniae Alba 150 parts, Pericarpium Citri Reticulatae 200 parts, Radix Platycodonis 250 parts by weight, mix 5-10 minute to even;
(3) take virazole 150 parts, doxycycline hydrochloride 70 parts, 250 parts, Radix Glycyrrhizae, Rhizoma Curcumae 200 parts, pentoxyverine citrate 70 parts by weight, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step are obtained, continue mixing 10-15 minute to even.
Embodiment 3
A kind of composition and method of making the same for the treatment of Infectious Tracheobroncheitis: carry out as follows: (every part by 10g)
(1) 500 mesh sieves are crossed after the Chinese medicine ingredients in prescription being carried out respectively micronizing;
(2) take propolis 350 parts, Flos Magnoliae 250 parts, the Radix Paeoniae Alba 250 parts, Pericarpium Citri Reticulatae 250 parts, Radix Platycodonis 350 parts by weight, mix 5-10 minute to even;
(3) take virazole 200 parts, doxycycline hydrochloride 100 parts, 350 parts, Radix Glycyrrhizae, Rhizoma Curcumae 250 parts, pentoxyverine citrate 100 parts by weight, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step are obtained, continue mixing 10-15 minute to even.
Clinical trial:
The ill dog that clinical experiment animal selected for 2 monthly ages at monthly age to 5, Laboratory Diagnosed is Infectious Tracheobroncheitis.Experimental dog isolation raised separately, complete feedstuff of feeding, and be divided into 3 groups at random, often organize 30,3 groups of feeding environments are identical, and experimental period carries out 7 days altogether; Blank group is left intact, and drug control group institute's control drug uses treatment by its description; Present composition group can by product of the present invention (compositions obtained by the embodiment of the present invention 1) feeding, and usage and dosage is: this product is waited temperature by per kilogram of body weight 10g ~ 12g and gavaged, every day 2 ~ 3 times.Reached the object of disease therapy by gastrointestinal absorption after oral.Computational methods: mortality rate=dead animal number/experimental animal number × 100%, cure rate=healing number of animals/experimental animal number × 100%.Following table is the result (testing the 7th day) at the end of experiment.
Table is that the situation that the present invention and other medicines treat Infectious Tracheobroncheitis contrasts:
| Numbering | Group | Mortality rate % | Cure rate % | At the end of have symptom rate % |
| I | Blank group | 40 | 10 | 50 |
| II | Hundstaupe health is fallen apart group | 16.7 | 63.3 | 20 |
| III | Present composition group | 6.7 | 76.7 | 16.6 |
Clinical effectiveness statistical analysis, present composition group and hundstaupe health to fall apart compared with group difference extremely significantly (P<0.01).
Safety testing:
Choose 2 monthly age healthy dogs 10,5 times of time temperature according to the made compositions recommended dose of the embodiment of the present invention 1 gavage 10 days, during medication, and observation experiment dog is without any bad or Deviant Behavior performance, and drinking-water of searching for food is normal.
Above-mentioned detailed description of the composition and method of making the same of this treatment Infectious Tracheobroncheitis being carried out with reference to embodiment; illustrative instead of determinate; several embodiments can be listed according to institute's limited range; therefore in the change do not departed under general plotting of the present invention and amendment, should belong within protection scope of the present invention.
Claims (3)
1. treat a compositions for Infectious Tracheobroncheitis, it is characterized in that by following component by weight mixed preparing form: propolis 15-35 part, Flos Magnoliae 10-25 part, Radix Paeoniae Alba 10-25 part, Pericarpium Citri Reticulatae 15-25 part, Radix Platycodonis 15-35 part, virazole 10-20 part, doxycycline hydrochloride 5-10 part, Radix Glycyrrhizae 15-35 part, Rhizoma Curcumae 15-25 part, pentoxyverine citrate 5-10 part.
2. the compositions for the treatment of Infectious Tracheobroncheitis according to claim 1, it is characterized in that by following component by weight mixed preparing form: propolis 25 parts, Flos Magnoliae 15 parts, the Radix Paeoniae Alba 15 parts, Pericarpium Citri Reticulatae 20 parts, Radix Platycodonis 25 parts, virazole 15 parts, doxycycline hydrochloride 7 parts, 25 parts, Radix Glycyrrhizae, Rhizoma Curcumae 20 parts, pentoxyverine citrate 7 parts.
3. a preparation method for the compositions for the treatment of Infectious Tracheobroncheitis according to claim 1, is characterized in that carrying out as follows:
(1) 500 mesh sieves are crossed after the Chinese medicine ingredients in prescription being carried out respectively micronizing;
(2) take propolis 15-35 part, Flos Magnoliae 10-25 part, Radix Paeoniae Alba 10-25 part, Pericarpium Citri Reticulatae 15-25 part, Radix Platycodonis 15-35 part by weight, mix 5-10 minute to even;
(3) take virazole 10-20 part, doxycycline hydrochloride 5-10 part, Radix Glycyrrhizae 15-35 part, Rhizoma Curcumae 15-25 part, pentoxyverine citrate 5-10 part by weight, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step are obtained, continue mixing 10-15 minute to even.
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Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1557432A (en) * | 2004-02-02 | 2004-12-29 | 四川省仁德制药有限公司 | Preparing process of medicinal composition for treating acute and chronic bronchitis |
| CN101422508A (en) * | 2007-11-02 | 2009-05-06 | 天津瑞普生物技术集团有限公司 | Traditional Chinese medicine oral liquid for treating poultry respiratory tract infection |
| CN102284027A (en) * | 2011-08-18 | 2011-12-21 | 荣成市商贸城卫生所 | Traditional Chinese medicine composition for treating bronchitis |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1557432A (en) * | 2004-02-02 | 2004-12-29 | 四川省仁德制药有限公司 | Preparing process of medicinal composition for treating acute and chronic bronchitis |
| CN101422508A (en) * | 2007-11-02 | 2009-05-06 | 天津瑞普生物技术集团有限公司 | Traditional Chinese medicine oral liquid for treating poultry respiratory tract infection |
| CN102284027A (en) * | 2011-08-18 | 2011-12-21 | 荣成市商贸城卫生所 | Traditional Chinese medicine composition for treating bronchitis |
Non-Patent Citations (2)
| Title |
|---|
| 活血化瘀法治疗支气管哮喘;张惠勇 等;《江西中医药》;20081231(第08期);5-8 * |
| 神奇的蜂胶与气管炎及其他;张龙海;《东方食疗与保健》;20041231(第12期);42-43 * |
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