CN102600259A - Complex propolis composition for treating eperythrozoon suis and preparation method thereof - Google Patents
Complex propolis composition for treating eperythrozoon suis and preparation method thereof Download PDFInfo
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- CN102600259A CN102600259A CN2011104342682A CN201110434268A CN102600259A CN 102600259 A CN102600259 A CN 102600259A CN 2011104342682 A CN2011104342682 A CN 2011104342682A CN 201110434268 A CN201110434268 A CN 201110434268A CN 102600259 A CN102600259 A CN 102600259A
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Abstract
The invention relates to a complex propolis composition for treating eperythrozoon suis and a preparation method thereof, and relates to the animal medicine field. The preparation method comprises the following steps that (1) each ingredient in the prescription is respectively micro-smashed to pass through a 700-mesh sieve; (2) 15 to 30 parts of propolis, 15 to 35 parts of rhizoma coptidis, 15 to 45 parts of Chinese bulbul and 15 to 35 parts of rhubarb are measured by weight and are blended for 5 to 10 minutes until being uniformly blended; (3) 15 to 45 parts of kuh-seng, 15 to 35 parts of cortex meliae, 15 to 40 parts of radix codonopsitis, 15 to 45 parts of radix dichroae and 15 to 45 parts of southernwood are measured by weight and are blended for 5 to 10 minutes until being uniformly blended; and (4) compositions respectively prepared in steps (2) and (3) are mixed to be continuously blended for 10 to 15 minutes until being uniformly blended. The complex propolis composition has beneficial effects that the prescription is reasonable, simplicity in preparation is realized, and the composition is toxic-free, has no side effect and is free from pollution, medicinal residue and drug resistance. Being micro-smashed, the biological availability is high, the curative effect is very remarkable, and a specially good effect on treating eperythrozoon suis is clinically proved.
Description
Technical field
The present invention relates to the animal field of medicaments, particularly a kind of compound bee-glue composition that is specifically designed to the treatment swine eperythrozoonosis and preparation method thereof.
Background technology
Swine eperythrozoonosis is that what to be caused by eperythrozoon suis is a boar infectious disease of characteristic with anemia, jaundice, heating.The pig of various ages and kind all can be taken place, and sick temperature of pig body raises, skin rubefaction, and constipation or diarrhoea, visual mucosa swelling flushing, packed cell volume reduces, organa parenchymatosum's enlargement, xanthochromia or hyperemia; Case fatality rate is between 30%-80%.Primary disease all can take place throughout the year, is one of principal disease of harm pig industry.
This disease almost spreads all over all countries of raising pigs of the world, distributes very extensively.At present, treat this disease the most frequently used be Chinese medicine and antimicrobial drug, Chinese medicine is because its prescription is unreasonable or just simple the pulverizing, and particle diameter is excessive, and drug release is slower, causes its bioavailability lower, clinical effectiveness is not fine; Antimicrobial drug since life-time service drug residue is arranged and be prone to produce drug resistance, its clinical effectiveness worse and worse, and drug residue cause exporting limited healthy with the harm people, thereby make the use of antimicrobial drug receive very big restriction.
Therefore researching and developing a kind of specific medicament of treating the drug residue free of swine eperythrozoonosis, the generation that has no drug resistance is one of this field scientific research technical staff new problem anxious to be solved.
Summary of the invention
The objective of the invention is to overcome above-mentioned weak point, provide that a kind of reasonable recipe, preparation are simple, micronizing, bioavailability are high, effect obviously, have no drug resistance and the compound bee-glue composition of effective treatment swine eperythrozoonosis of drug residue and preparation method thereof.
Following for realizing the embodiment that above-mentioned purpose the present invention adopted: a kind of compound bee-glue composition of treating swine eperythrozoonosis, by following component by weight mixed preparing form: propolis 15-30 part, Rhizoma Coptidis 15-35 part, Radix Pulsatillae 15-45 part, Radix Et Rhizoma Rhei 15-35 part, Radix Sophorae Flavescentis 15-45 part, Cortex Meliae 15-35 part, Radix Codonopsis 15-40 part, Radix Dichroae 15-45 part, Herba Artemisiae Annuae 15-45 part.
On the basis of such scheme, said various component optimum ratio amounts are: 25 parts of propolis, 25 parts of Rhizoma Coptidis, 30 parts of the Radix Pulsatillaes, 25 parts of Radix Et Rhizoma Rhei, 30 parts of Radix Sophorae Flavescentiss, 25 parts of Cortex Meliaees, 25 parts of Radix Codonopsis, 30 parts of Radix Dichroaes, 30 parts of Herba Artemisiae Annuaes.
A kind of method for preparing of treating the compound bee-glue composition of swine eperythrozoonosis, carry out as follows:
(1) the various compositions in the prescription is crossed 700 mesh sieves after the micronizing respectively;
(2) take by weighing propolis 15-30 part, Rhizoma Coptidis 15-35 part, Radix Pulsatillae 15-45 part, Radix Et Rhizoma Rhei 15-35 part by weight, mix 5-10 minute to even;
(3) take by weighing Radix Sophorae Flavescentis 15-45 part, Cortex Meliae 15-35 part, Radix Codonopsis 15-40 part, Radix Dichroae 15-45 part, Herba Artemisiae Annuae 15-45 part by weight, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
The medicinal property of each component is following:
Propolis: bitter, hot, cold, return spleen, stomach warp, have the function of anti-inflammation, antalgesic-antipruritic, promotion tissue regeneration, raising immunity, antiallergic oxidation, hemostasis, protection gastrointestinal mucosa.
Rhizoma Coptidis: bitter, cold, return spleen, stomach, large intestine, gallbladder, heart channel, have the function of heat clearing and damp drying, eliminating fire and detoxication; Cure mainly damp-heat dysentery, hyperactivity of heart-fire, excessiveness of stomach-fire, dampness-heat in the liver and gallbladder etc.
The Radix Pulsatillae: bitter, cold, return stomach, large intestine channel, have the function of heat-clearing and toxic substances removing, eliminating pathogenic heat from blood to cure dysentery; Cure mainly toxic-heat and blood stasis, damp and hot intestinal Huang etc.
Radix Et Rhizoma Rhei: bitter, cold, return large intestine, spleen, stomach, liver, pericardium channel, have the function of purging heat and dredging bowels, removing pathogenic heat from blood and toxic substance from the body, removing mass blood stasis expelling; Cure mainly excess-heat constipation, combined symptoms, the yellow furunculosis of skin ulcer, conjunctival congestion and swelling pain, enteritis etc.
Radix Sophorae Flavescentis: bitter, cold, return liver, stomach, large intestine, the heart, urinary bladder channel, have that heat clearing and damp drying, parasite killing go to amass, the function of diuretic; Cure mainly damp-heat dysentery, jaundice, edema, scabies etc.
Cortex Meliae: hot, cold, return stomach, spleen, Liver Channel, have the function of parasite killing, treatment tinea; Cure mainly abdominal pain due to worm stagnation, scabies etc.
Radix Codonopsis: sweet, flat, return spleen, lung meridian, have functions such as invigorating the spleen and replenishing QI, spleen invigorating lung benefiting, cure mainly weakness of the spleen and stomach, eat diarrhoea, cough and asthma due to lung deficiency, fatigue and lack of strength, the deficiency of vital energy less and hang down and take off etc.
Radix Dichroae: bitter, hot, cold, return lung, liver, heart channel, have the function of parasite killing, expectorant removing food stagnancy; Curing mainly protozoacide, the impaction of rumen, phlegm retention gathers etc.
Herba Artemisiae Annuae: bitter, hot, cold, return liver, gallbladder meridian, have clearing away summer-heat, reducing the asthenic fever, protozoacide function; Cure mainly protozoacide, babesiasis, jaundice due to damp-heat etc.
More than all flavor Chinese medicine according to the Chinese medical theory compatible combination, to pathogenic microorganism, clinical symptoms and the pathological change of swine eperythrozoonosis, the effect of performance treating both the principal and secondary aspects of a disease.
The invention has the beneficial effects as follows: reasonable recipe, preparation is simple, and substep mixes more even; Chinese medicine composition is pollution-free, no drug residue, have no drug resistance, and cost is low, and it is wide to draw materials, and micronizing, bioavailability are high, the curative effect highly significant.The present invention is according to Chinese veterinarian's traditional theory; Optimize this nine flavors Chinese medicine, and make them form pure Chinese powder medicine according to optimum ratio, clinical practice proves; The treatment swine eperythrozoonosis there is specially good effect; And make its product meat reach nuisanceless requirement, satisfy the export standard of product, guaranteed that effectively people's is healthy.
The specific embodiment
Below in conjunction with preferred embodiment, to details are as follows according to the specific embodiment provided by the invention:
Embodiment 1
A kind of compound bee-glue composition of treating swine eperythrozoonosis and preparation method thereof: carry out as follows: (every part by 10g)
(1) the various compositions in the prescription is crossed 700 mesh sieves after the micronizing respectively;
(2) take by weighing 150 parts of propolis, 150 parts of Rhizoma Coptidis, 150 parts of the Radix Pulsatillaes, 150 parts of Radix Et Rhizoma Rhei by weight, mix 5-10 minute to even;
(3) take by weighing 150 parts of Radix Sophorae Flavescentiss, 150 parts of Cortex Meliaees, 150 parts of Radix Codonopsis, 150 parts of Radix Dichroaes, 150 parts of Herba Artemisiae Annuaes by weight, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Embodiment 2
A kind of compound bee-glue composition of treating swine eperythrozoonosis and preparation method thereof: carry out as follows: (every part by 10g)
(1) the various compositions in the prescription is crossed 700 mesh sieves after the micronizing respectively;
(2) take by weighing 250 parts of propolis, 250 parts of Rhizoma Coptidis, 300 parts of the Radix Pulsatillaes, 250 parts of Radix Et Rhizoma Rhei by weight, mix 5-10 minute to even;
(3) take by weighing 300 parts of Radix Sophorae Flavescentiss, 250 parts of Cortex Meliaees, 250 parts of Radix Codonopsis, 300 parts of Radix Dichroaes, 300 parts of Herba Artemisiae Annuaes by weight, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Embodiment 3
A kind of compound bee-glue composition of treating swine eperythrozoonosis and preparation method thereof: carry out as follows: (every part by 10g)
(1) the various compositions in the prescription is crossed 700 mesh sieves after the micronizing respectively;
(2) take by weighing 300 parts of propolis, 350 parts of Rhizoma Coptidis, 450 parts of the Radix Pulsatillaes, 350 parts of Radix Et Rhizoma Rhei by weight, mix 5-10 minute to even;
(3) take by weighing 450 parts of Radix Sophorae Flavescentiss, 350 parts of Cortex Meliaees, 400 parts of Radix Codonopsis, 450 parts of Radix Dichroaes, 450 parts of Herba Artemisiae Annuaes by weight, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Clinical trial:
With the ill pig of product feeding of the present invention etc., a day dose is: by the every 100g of the present invention, spice 210kg feeds, drinking-water 400kg, every day 2-3 time, logotype 3-5 day; Oral back reaches the purpose of treatment disease through gastrointestinal absorption.
Table is the field applicable cases contrast of the present invention and other medicines treatment swine eperythrozoonosis:
| Numbering | Group | Case fatality rate % | Cure rate % | Symptom rate % is arranged during end |
| I | The blank group | 35.9 | 54.5 | 18.6 |
| II | Attaches red dissipation group | 11.7 | 79.0 | 9.3 |
| III | Present composition group | 5.4 | 90.5 | 4.1 |
This clinical effectiveness is through statistical analysis, and present composition treatment group is attached red dissipation group with pig and comparing difference extremely significantly (P＜0.01) aspect the cure rate.
Above-mentioned detailed description of compound bee-glue composition of this treatment swine eperythrozoonosis and preparation method thereof being carried out with reference to embodiment; Be illustrative rather than determinate; Can enumerate out several embodiment according to institute's limited range; Therefore in the variation and the modification that do not break away under the general plotting of the present invention, should belong within protection scope of the present invention.
Claims (3)
1. compound bee-glue composition of treating swine eperythrozoonosis, it is characterized in that by following component by weight mixed preparing form: propolis 15-30 part, Rhizoma Coptidis 15-35 part, Radix Pulsatillae 15-45 part, Radix Et Rhizoma Rhei 15-35 part, Radix Sophorae Flavescentis 15-45 part, Cortex Meliae 15-35 part, Radix Codonopsis 15-40 part, Radix Dichroae 15-45 part, Herba Artemisiae Annuae 15-45 part.
2. a kind of compound bee-glue composition of treating swine eperythrozoonosis according to claim 1, it is characterized in that by following component by weight mixed preparing form: 25 parts of propolis, 25 parts of Rhizoma Coptidis, 30 parts of the Radix Pulsatillaes, 25 parts of Radix Et Rhizoma Rhei, 30 parts of Radix Sophorae Flavescentiss, 25 parts of Cortex Meliaees, 25 parts of Radix Codonopsis, 30 parts of Radix Dichroaes, 30 parts of Herba Artemisiae Annuaes.
3. the method for preparing of the compound bee-glue composition of a treatment swine eperythrozoonosis according to claim 1 and 2 is characterized in that carrying out as follows:
(1) the various compositions in the prescription is crossed 700 mesh sieves after the micronizing respectively;
(2) take by weighing propolis 15-30 part, Rhizoma Coptidis 15-35 part, Radix Pulsatillae 15-45 part, Radix Et Rhizoma Rhei 15-35 part by weight, mix 5-10 minute to even;
(3) take by weighing Radix Sophorae Flavescentis 15-45 part, Cortex Meliae 15-35 part, Radix Codonopsis 15-40 part, Radix Dichroae 15-45 part, Herba Artemisiae Annuae 15-45 part by weight, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN103652449A (en) * | 2013-12-09 | 2014-03-26 | 山东新希望六和集团有限公司 | Feed for treating Eperythrozoon suis, and preparation method thereof |
| CN105769988A (en) * | 2014-12-26 | 2016-07-20 | 北京大北农动物保健科技有限责任公司 | Traditional Chinese medicine composition for treating swine eperythrozoonosis and preparation method thereof |
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| US20090068218A1 (en) * | 2005-09-09 | 2009-03-12 | Universitat Zurich | Antigens for Vaccination Against and Detection of Mycoplasma Suis |
| US20090082220A1 (en) * | 2005-03-15 | 2009-03-26 | Krause Duncan C | Surface enhanced Raman spectroscopy (SERS) systems for the detection of bacteria and methods of use thereof |
| CN101879201A (en) * | 2010-07-02 | 2010-11-10 | 中国农业科学院兰州畜牧与兽药研究所 | Medicine for preventing and curing eperythrozoonosis of pigs, sheep and cows and preparation method thereof |
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Patent Citations (3)
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| US20090082220A1 (en) * | 2005-03-15 | 2009-03-26 | Krause Duncan C | Surface enhanced Raman spectroscopy (SERS) systems for the detection of bacteria and methods of use thereof |
| US20090068218A1 (en) * | 2005-09-09 | 2009-03-12 | Universitat Zurich | Antigens for Vaccination Against and Detection of Mycoplasma Suis |
| CN101879201A (en) * | 2010-07-02 | 2010-11-10 | 中国农业科学院兰州畜牧与兽药研究所 | Medicine for preventing and curing eperythrozoonosis of pigs, sheep and cows and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103652449A (en) * | 2013-12-09 | 2014-03-26 | 山东新希望六和集团有限公司 | Feed for treating Eperythrozoon suis, and preparation method thereof |
| CN105769988A (en) * | 2014-12-26 | 2016-07-20 | 北京大北农动物保健科技有限责任公司 | Traditional Chinese medicine composition for treating swine eperythrozoonosis and preparation method thereof |
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