CN102670804A - Compound propolis composition for treating poultry dysentery and preparation method thereof - Google Patents

Abstract

The invention discloses a compound propolis composition for treating poultry dysentery and a preparation method thereof, which relate to the field of animal medicine. The composition is prepared by mixing the following components in parts by weight: 15-30 parts of propolis, 15-30 parts of common andrographis Herb, 15-40 parts of realgar, 15-45 parts of mung bean, 10-30 parts of sulfur, 15-50 parts of alum, 15-35 parts of liquoric root, 15-45 parts of amur corktree bark, 15-35 parts of Chinese pulsatilla root and 15-45 parts of honeysuckle flower. The compound propolis composition has the beneficial effects of reasonable composition, easiness for preparing, freeness from toxic and side effects, environment friendliness, no medicament residues, no medicament resistance, ultrafine smashing, high bioavailability and very remarkable curative effect; and as proved by clinic, the compound propolis composition has a special treatment effect on poultry dysentery.

Description

A kind of compound bee-glue composition of treating avian dysentery and preparation method thereof

Technical field

The present invention relates to compound bee-glue composition of treating avian dysentery and preparation method thereof, belong to the animal field of medicaments, particularly a kind of compound bee-glue composition that is specifically designed to the treatment avian dysentery and preparation method thereof.

Background technology

Avian dysentery mainly comprises the general name of the symptom of diarrhea that is caused by various factorss such as antibacterial, virus, parasites.Long-term serious dysentery can be lost large quantity of moisture, salt and alkaline matter, and in various degree dehydration, salt deficiency and acidosis take place, and blood thickens and contracts, thereby influences the normal circulation of body fluid, causes that finally heart failure causes death.The more little sickness rate of poultry age in days is high more, and case fatality rate is also high more, is generally between the 10%-40%.Primary disease all can take place throughout the year, is one of principal disease of harm poultry farming.

Western medical treatment mainly is bactericidal antiphlogistic and additional body fluid, and the traditional Chinese medical science thinks that primary disease mainly is that pyretic toxicity amasss in the caused dysentery of gastrointestinal, belongs to the interior-excess heat syndrome, and treatment should be adopted the principle of heat-clearing and toxic substances removing, eliminating dampness by diuresis astringent therapy.

This disease almost spreads all over all livestock culturing countries of the world, distributes very extensively.At present, treat this disease the most frequently used be Chinese medicine and Western medicine, Chinese medicine is because its prescription is unreasonable or just simple the pulverizing, and particle diameter is excessive, and drug release is slower, causes its bioavailability lower, clinical effectiveness is not fine; And Western medicine produces problems such as drug resistance and drug residue owing to its toxic and side effects is strong, easy, and clinical practice is very limited or bans use of.

Therefore research and develop that a kind of to treat the having no side effect of avian dysentery, drug residue free, the specific medicament that produces that has no drug resistance be one of this field scientific research technical staff new problem anxious to be solved.

Summary of the invention

The objective of the invention is to overcome above-mentioned weak point, provide that a kind of reasonable recipe, preparation are simple, micronizing, bioavailability are high, effect obviously, have no side effect, have no drug resistance and the compound bee-glue composition of effective treatment avian dysentery of drug residue and preparation method thereof.

Following for realizing the embodiment that above-mentioned purpose the present invention adopted: a kind of compound bee-glue composition of treating avian dysentery, by following component by weight mixed preparing form: propolis 15-30 part, Herba Andrographis 15-30 part, Realgar 15-40 part, Semen phaseoli radiati 15-45 part, sulfur 10-30 part, Alumen 15-50 part, Radix Glycyrrhizae 15-35 part, Cortex Phellodendri 15-45 part, Radix Pulsatillae 15-35 part, Flos Lonicerae 15-45 part.

Said various component optimum ratio amount is: 25 parts of propolis, 25 parts of Herba Andrographis, 20 parts of Realgars, 30 parts in Semen phaseoli radiati, 20 parts in sulfur, 45 parts in Alumen, 25 parts in Radix Glycyrrhizae, 30 parts of Cortex Phellodendris, 25 parts of the Radix Pulsatillaes, 30 parts of Flos Loniceraes.

A kind of method for preparing of treating the compound bee-glue composition of avian dysentery, carry out as follows:

(1) the various compositions in the prescription is crossed 700 mesh sieves after the micronizing respectively;

(2) take by weighing propolis 15-30 part, Herba Andrographis 15-30 part, Realgar 15-40 part, Semen phaseoli radiati 15-45 part, sulfur 10-30 part by weight, mix 5-10 minute to even;

(3) take by weighing Alumen 15-50 part, Radix Glycyrrhizae 15-35 part, Cortex Phellodendri 15-45 part, Radix Pulsatillae 15-35 part, Flos Lonicerae 15-45 part by weight, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.

The medicinal property of each component is following:

Propolis: bitter, hot, cold, return spleen, stomach warp, have the function of anti-inflammation, antalgesic-antipruritic, promotion tissue regeneration, raising immunity, antiallergic oxidation, hemostasis, protection gastrointestinal mucosa.

Herba Andrographis: bitter, cold, GUIXIN, lung, bladder, large intestine channel have the function of heat-clearing and toxic substances removing, reducing swelling and alleviating pain; Cure mainly cold, fever, damp-heat diarrhea, carbuncle sore furunculosis etc.

Cortex Phellodendri: bitter, cold, return kidney, urinary bladder channel, have the function of heat clearing and damp drying, eliminating fire and detoxication, reducing the asthenic fever; Cure mainly damp-heat dysentery, jaundice, pyretic stranguria, sore swollen toxin, eczema, hyperactivity of fire caused by deficiency of YIN etc.

Semen phaseoli radiati: sweet, cool, GUIXIN, stomach warp, the function that has heat-clearing and toxic substances removing, relieves summer heat and be good for the stomach; Cure mainly that diarrhea due to damp-heat, detoxifcation protect the liver, antiallergic etc.

Alumen: cold, acid, puckery, return lung, spleen, large intestine, Liver Channel, have heat clearing away expectorant, hemostasis antidiarrheal, dampness removing to stop itchin, the parasiticidal function of detoxifcation; Cure mainly incessant chronic diarrhea, heavily wait after having blood in stool, let out dysentery.

Radix Glycyrrhizae: sweet, flat, return lung, the heart, spleen channel, have invigorating the spleen and replenishing QI, expelling phlegm for arresting cough and middle emergency, detoxifcation, coordinating the actions of various ingredients in a prescription, cushion toxicity, strong function; Cure mainly weakness of the spleen and stomach, cough with asthma, poisoning etc.

The Radix Pulsatillae: bitter, cold, return stomach, large intestine channel, have the function of heat-clearing and toxic substances removing, eliminating pathogenic heat from blood to cure dysentery; Cure mainly toxic-heat and blood stasis, damp and hot removing heat from blood etc.

Realgar: hot, temperature, poisonous, return liver, large intestine channel, have the function of detoxifcation parasite killing, removing dampness and eliminating phlegm; Cure mainly carbuncle sore tumefacting virus, abdominal pain due to worm stagnation, infantile convulsion, scabies etc.

Sulfur: acid, temperature, poisonous, return kidney, large intestine channel, have and mend function fiery supporing yang, relieving constipation; Cure mainly yang deficiency constipation, deficiency and coldness asthma, scabies, carbuncle of yin nature malignant boil etc.

Flos Lonicerae: sweet, cold, return lung, the heart, stomach warp, have the function of heat-clearing and toxic substances removing, dispelling wind and heat pathogens; Cure mainly cough due to lung-heat, toxic-heat and blood stasis, carbuncle sore tumefacting virus etc.

More than all flavor Chinese medicine according to the Chinese medical theory compatible combination, to the paathogenic factor and the clinical symptoms of avian dysentery, the effect of performance treating both the principal and secondary aspects of a disease.

The invention has the beneficial effects as follows: reasonable recipe, preparation is simple, and substep mixes more even; Chinese medicine composition is pollution-free, have no side effect, no drug residue, have no drug resistance, and cost is low, and it is wide to draw materials, and micronizing, bioavailability are high, the curative effect highly significant.The present invention is according to Chinese veterinarian's traditional theory; Optimize this ten flavors Chinese medicine, and make them form pure Chinese powder medicine according to optimum ratio, clinical practice proves; The treatment avian dysentery there is specially good effect; And make its product meat reach nuisanceless requirement, satisfy the export standard of product, guaranteed that effectively people's is healthy.

The specific embodiment

Below in conjunction with preferred embodiment, to details are as follows according to the specific embodiment provided by the invention:

Embodiment 1

A kind of compound bee-glue composition of treating avian dysentery and preparation method thereof: carry out as follows: (every part by 10g)

(1) the various compositions in the prescription is crossed 700 mesh sieves after the micronizing respectively;

(2) take by weighing 150 parts of propolis, 150 parts of Herba Andrographis, 150 parts of Realgars, 150 parts in Semen phaseoli radiati, 100 parts in sulfur by weight, mix 5-10 minute to even;

(3) take by weighing 150 parts in Alumen, 150 parts in Radix Glycyrrhizae, 150 parts of Cortex Phellodendris, 150 parts of the Radix Pulsatillaes, 150 parts of Flos Loniceraes by weight, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.

Embodiment 2

A kind of compound bee-glue composition of treating avian dysentery and preparation method thereof: carry out as follows: (every part by 10g)

(1) the various compositions in the prescription is crossed 700 mesh sieves after the micronizing respectively;

(2) take by weighing 200 parts of propolis, 250 parts of Herba Andrographis, 250 parts of Realgars, 300 parts in Semen phaseoli radiati, 150 parts in sulfur by weight, mix 5-10 minute to even;

(3) take by weighing 300 parts in Alumen, 250 parts in Radix Glycyrrhizae, 300 parts of Cortex Phellodendris, 250 parts of the Radix Pulsatillaes, 300 parts of Flos Loniceraes by weight, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.

Embodiment 3

A kind of compound bee-glue composition of treating avian dysentery and preparation method thereof: carry out as follows: (every part by 10g)

(1) the various compositions in the prescription is crossed 700 mesh sieves after the micronizing respectively;

(2) take by weighing 300 parts of propolis, 300 parts of Herba Andrographis, 400 parts of Realgars, 450 parts in Semen phaseoli radiati, 300 parts in sulfur by weight, mix 5-10 minute to even;

(3) take by weighing 500 parts in Alumen, 350 parts in Radix Glycyrrhizae, 450 parts of Cortex Phellodendris, 350 parts of the Radix Pulsatillaes, 450 parts of Flos Loniceraes by weight, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.

Clinical trial:

The clinical experiment animal selects for use 20-40 age in days, body weight at 1.2kg-2.5kg, and laboratory is diagnosed as the ill broiler of Pullorum Disease.Ill chicken is isolated raising separately, the complete feed of feeding, and be divided into 3 groups at random, and 30 every group, 3 groups of feeding environments are identical, and experimental period was carried out 7 days altogether; The blank group is left intact, and the medicine matched group uses treatment with " the dysentery health is loose " by specification; Chinese medicine composition group of the present invention is with the ill poultry of product feeding of the present invention etc., and a day dose is: by the every 100g of the present invention, spice 260kg feeds, drinking-water 400kg, every day 2-3 time, logotype 3-5 day; Oral back reaches the purpose of treatment disease through gastrointestinal absorption.Result's (testing the 8th day) when following table is the experiment end.

Table is the field applicable cases contrast of the present invention and other medicines treatment avian dysenteries (chicken):

Numbering	Group	Mortality rate %	Cure rate %	Symptom rate % is arranged during end
					I	The blank group	13.6	52.6	33.8
II	The dysentery health is loose and is organized	9.1	79.4	11.5
					III	Present composition group	5.2	88.3	6.5

This clinical effectiveness is through statistical analysis, and present composition treatment group is loose to organize with the dysentery health and compared significant difference (P＜0.05) aspect the cure rate.

Above-mentioned detailed description of compound bee-glue composition of this treatment avian dysentery and preparation method thereof being carried out with reference to embodiment; Be illustrative rather than determinate; Can enumerate out several embodiment according to institute's limited range; Therefore in the variation and the modification that do not break away under the general plotting of the present invention, should belong within protection scope of the present invention.

Claims (3)

1. compound bee-glue composition of treating avian dysentery, it is characterized in that by following component by weight mixed preparing form: propolis 15-30 part, Herba Andrographis 15-30 part, Realgar 15-40 part, Semen phaseoli radiati 15-45 part, sulfur 10-30 part, Alumen 15-50 part, Radix Glycyrrhizae 15-35 part, Cortex Phellodendri 15-45 part, Radix Pulsatillae 15-35 part, Flos Lonicerae 15-45 part.

2. the compound bee-glue composition of treatment avian dysentery according to claim 1, it is characterized in that by following component by weight mixed preparing form: 25 parts of propolis, 25 parts of Herba Andrographis, 20 parts of Realgars, 30 parts in Semen phaseoli radiati, 20 parts in sulfur, 45 parts in Alumen, 25 parts in Radix Glycyrrhizae, 30 parts of Cortex Phellodendris, 25 parts of the Radix Pulsatillaes, 30 parts of Flos Loniceraes.

3. the method for preparing of the compound bee-glue composition of a treatment avian dysentery according to claim 1 and 2 is characterized in that carrying out as follows:

(1) the various compositions in the prescription is crossed 700 mesh sieves after the micronizing respectively;

(2) take by weighing propolis 15-30 part, Herba Andrographis 15-30 part, Realgar 15-40 part, Semen phaseoli radiati 15-45 part, sulfur 10-30 part by weight, mix 5-10 minute to even;

(3) take by weighing Alumen 15-50 part, Radix Glycyrrhizae 15-35 part, Cortex Phellodendri 15-45 part, Radix Pulsatillae 15-35 part, Flos Lonicerae 15-45 part by weight, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.