CN103877545A - Traditional Chinese medicinal composition for treating poultry diarrhea and preparation method thereof - Google Patents

Abstract

The invention relates to a traditional Chinese medicinal composition for treating poultry diarrhea. The composition is prepared by mixing the following components in parts by weight: 25-50 parts of Chinese mahonia, 15-35 parts of clove, 15-45 parts of illicium verum, 15-45 parts of catechu, 10-40 parts of wikstroemia indica, 15-60 parts of saururus chinensis, 15-35 parts of liquorice, 15-45 parts of root of chinese barberry, 15-35 parts of dried ginger, 15-45 parts of prepared ginger, 15-55 parts of garlic and 15-45 parts of yam. The traditional Chinese medicinal composition has the beneficial effects of reasonable formula, simple preparation, no toxic or side effect, no drug residue, no drug resistance, superfine grinding, high bioavailability and remarkable curative effect, and has a special effect in treating poultry diarrhea by virtue of clinical verification.

Description

Chinese medicine composition for the treatment of avian dysentery and preparation method thereof

Technical field

The present invention relates to Chinese medicine composition for the treatment of avian dysentery and preparation method thereof, belong to animal field of medicaments, particularly a kind of Chinese medicine composition that is specifically designed to treatment avian dysentery and preparation method thereof.

Background technology

Avian dysentery mainly comprises the general name of the symptom of diarrhea being caused by various factorss such as antibacterial, virus, parasites.Long-term serious dysentery, can lose large quantity of moisture, salt and alkaline matter, and dehydration, salt deficiency and acidosis in various degree occur, the blood contracting that thickens, thus affect the normal circulation of body fluid, finally cause that heart failure causes death.The less sickness rate of poultry age in days is higher, and case fatality rate is also higher, is generally between 10%-40%.Primary disease all can occur throughout the year, is one of principal disease of harm poultry farming.

Western medical treatment is mainly bactericidal antiphlogistic and supplementary body fluid, and the traditional Chinese medical science thinks that primary disease is mainly that pyretic toxicity amasss in the caused dysentery of gastrointestinal, belongs to interior-excess heat syndrome, and treatment should adopt the principle of heat-clearing and toxic substances removing, eliminating dampness by diuresis astringent therapy.

This disease almost spreads all over all livestock culturings country of the world, is widely distributed.At present, treat this disease the most frequently used be Chinese medicine and Western medicine, Chinese medicine is because its prescription is unreasonable or simple pulverizing just, particle diameter is excessive, drug release is slower, causes its bioavailability lower, clinical effectiveness is not fine; And Western medicine is because its toxic and side effects by force, easily produces the problem such as drug resistance and drug residue, clinical practice is very limited or bans use of.

Therefore research and develop and a kind ofly treat the having no side effect of avian dysentery, drug residue free, the specific medicament producing that has no drug resistance is one of this field scientific research technical staff new problem anxious to be resolved.

Summary of the invention

The object of the invention is to overcome above-mentioned weak point, provide that a kind of reasonable recipe, preparation are simple, micronizing, bioavailability are high, successful, have no side effect, have no drug resistance and the Chinese medicine composition of effective treatment avian dysentery of drug residue and preparation method thereof.

Implementation of the present invention is as follows for achieving the above object: a kind of Chinese medicine composition for the treatment of avian dysentery, it is characterized in that by following component by weight mixed preparing form: Mahonia fortunei (Lindl.) Fedde 25-50 part, Flos Caryophylli 15-35 part, Fructus Anisi Stellati 15-45 part, catechu 15-45 part, Radix Wikstroemae 10-40 part, Rhizoma Saururi (Herba Saururi) 15-60 part, Radix Glycyrrhizae 15-35 part, Radix Berberidis 15-45 part, Rhizoma Zingiberis 15-35 part, Rhizoma Zingiberis Preparatum 15-45 part, Bulbus Allii 15-55 part, Rhizoma Dioscoreae 15-45 part.

Described various component optimum ratio amount is: 40 parts of Mahonia fortunei (Lindl.) Fedde, 25 parts of Flos Caryophyllis, 30 parts of Fructus Anisi Stellatis, 30 parts, catechu, 25 parts of Radix Wikstroemae, 40 parts of Rhizoma Saururi (Herba Saururi)s, 25 parts, Radix Glycyrrhizae, 30 parts of Radix Berberidis, 25 parts of Rhizoma Zingiberiss, 30 parts of Rhizoma Zingiberis Preparatums, 35 parts, Bulbus Allii, 30 parts of Rhizoma Dioscoreaes.

A preparation method for the treatment of the group Chinese medicine compound of avian dysentery, is characterized in that carrying out as follows:

(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;

(2) take by weight Mahonia fortunei (Lindl.) Fedde 25-50 part, Flos Caryophylli 15-35 part, Fructus Anisi Stellati 15-45 part, catechu 15-45 part, Radix Wikstroemae 10-40 part, Rhizoma Saururi (Herba Saururi) 15-60 part, mix 5-10 minute to even;

(3) take by weight Radix Glycyrrhizae 15-35 part, Radix Berberidis 15-45 part, Rhizoma Zingiberis 15-35 part, Rhizoma Zingiberis Preparatum 15-45 part, Bulbus Allii 15-55 part, Rhizoma Dioscoreae 15-45 part, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.

The medicinal property of each component is as follows:

Mahonia fortunei (Lindl.) Fedde: bitter, cold, GUIXIN, small intestinal, liver, gallbladder, lung, stomach, large intestine channel, have the function of heat clearing and damp drying, removing toxic substances dysentery relieving; Cure mainly the yellow dysentery of intestinal, jaundice due to damp-heat, laryngopharynx swelling and pain, conjunctival congestion and swelling pain, sore, eczema, enteritis etc.

Flos Caryophylli: pungent, warm, return spleen, lung, stomach, kidney channel, there is the function of warming middle-JIAO to send down the adverse QI, reinforcing the kidney and supporting YANG; Cure mainly gastrofrigid vomiting, tripe is swollen, cold intestinal is had loose bowels, impotence due to deficiency of the kidney, cold womb etc.

Fructus Anisi Stellati: pungent, warm, return spleen, liver, stomach, kidney channel, there is the function of warming spleen and stomach for dispelling cold, regulating QI to relieve pain; Cure mainly gastrofrigid vomiting, cold stagnant stomachache, lumbago due to renal deficiency etc.

Catechu: bitter, puckery, be slightly cold, return lung, heart channel, there is the function of hemostasis with astringents, promoting tissue regeneration and ulcer healing, removing heat from the lung and dissipating phlegm; Treatment of ulcer is not received, eczema, aphtha, cough due to lung-heat etc.

Radix Wikstroemae: bitter, cold, GUIXIN, small intestinal, large intestine channel, have the function of heat-clearing and toxic substances removing, dissipating blood stasis for subsidence of swelling, diuretic; Cure mainly high hot sun stroke, rheumatic arthralgia, skin ulcer general edema with yellowish skin poison, edema tympanites etc.

Radix Glycyrrhizae: sweet, flat, return lung, the heart, spleen channel, there is invigorating the spleen and replenishing QI, expelling phlegm for arresting cough and middle emergency, removing toxic substances, coordinating the actions of various ingredients in a prescription, cushion toxicity, strong function; Cure mainly weakness of the spleen and stomach, cough with asthma, poisoning etc.

Rhizoma Saururi (Herba Saururi): sweet, pungent, cold, return lung, urinary bladder channel, there is the function of heat-clearing and toxic substances removing, inducing diuresis to remove edema; Cure mainly damp-heat in the urinary bladder, dysuria, edema of the limbs, the yellow furunculosis of skin ulcer etc.

Radix Berberidis: bitter, cold, return liver, stomach, large intestine channel, there is the function of heat clearing and damp drying, eliminating fire and detoxication; Cure mainly that hematodiarrhoea is had blood in stool, jaundice due to damp-heat, conjunctival congestion and swelling pain, laryngopharynx swelling and pain, eczema, skin ulcer general edema with yellowish skin poison etc.

Rhizoma Zingiberis: pungent, hot, return spleen, stomach, the heart, kidney, lung meridian, have that warming spleen and stomach for dispelling cold, recuperating depleted YANG are promoted blood circulation, the function of dampness expectorant; Cure mainly that cold syndrome of the stomach lack of appetite, cold intestinal are had loose bowels, cold type of pain, extreme cold of the limbs, anemofrigid-damp arthralgia, phlegm retention breath with cough etc.

Rhizoma Zingiberis Preparatum: pungent, hot, return spleen, stomach, kidney channel, have that warming spleen and stomach for dispelling cold, recuperating depleted YANG are promoted blood circulation, the function of dampness expectorant; Cure mainly that cold syndrome of the stomach lack of appetite, cold intestinal are had loose bowels, cold type of pain, extreme cold of the limbs, anemofrigid-damp arthralgia, phlegm retention breath with cough etc.

Bulbus Allii: pungent, warm, return spleen, stomach, lung meridian, there is the function of the appetizing of regulating the flow of vital energy, removing toxic substances, dysentery relieving, parasite killing; Cure mainly that slow grass is not eaten, tripe distention and fullness in the abdomen, dysentery, abdominal pain due to worm stagnation etc.

Rhizoma Dioscoreae: sweet, flat, return spleen, stomach, kidney channel, have that spleen reinforcing nourishing the stomach, lung benefiting are promoted the production of body fluid, the function of the kidney invigorating arresting seminal emission; Cure mainly that weakness of the spleen and stomach, inappetence, diarrhea due to hypofunction of the spleen, asthenia are breathed with cough, spermatorrhea, leukorrhagia, frequent micturition number etc.

All taste Chinese medicine, according to Chinese medical theory compatible combination, for paathogenic factor and the clinical symptoms of avian dysentery, is brought into play the effect for the treatment of both the principal and secondary aspects of a disease above.

The invention has the beneficial effects as follows: reasonable recipe, preparation is simple, and substep mixes more even; Chinese medicine composition is pollution-free, have no side effect, no drug residue, have no drug resistance, and cost is low, draws materials wide, and micronizing, bioavailability are high, curative effect highly significant.The present invention is according to Chinese veterinarian's traditional theory, optimize this 12 taste Chinese medicine, and make them form pure Chinese powder medicine according to optimum ratio, clinical practice proves, treatment avian dysentery is had to specially good effect, and make its product meat reach nuisanceless requirement, meet the export standard of product, effectively ensured that people's is healthy.

Detailed description of the invention

Below in conjunction with preferred embodiment, to according to detailed description of the invention provided by the invention, details are as follows:

Embodiment 1

A kind of Chinese medicine composition for the treatment of avian dysentery and preparation method thereof: carry out as follows: (every part by 10g)

(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;

(2) take by weight 250 parts of Mahonia fortunei (Lindl.) Fedde, 150 parts of Flos Caryophyllis, 150 parts of Fructus Anisi Stellatis, 150 parts, catechu, 100 parts of Radix Wikstroemae, 150 parts of Rhizoma Saururi (Herba Saururi)s, mix 5-10 minute to even;

(3) take by weight 150 parts, Radix Glycyrrhizae, 150 parts of Radix Berberidis, 150 parts of Rhizoma Zingiberiss, 150 parts of Rhizoma Zingiberis Preparatums, 150 parts, Bulbus Allii, 150 parts of Rhizoma Dioscoreaes, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.

Embodiment 2

A kind of Chinese medicine composition for the treatment of avian dysentery: carry out as follows: (every part by 10g)

(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;

(2) take by weight 400 parts of Mahonia fortunei (Lindl.) Fedde, 250 parts of Flos Caryophyllis, 300 parts of Fructus Anisi Stellatis, 300 parts, catechu, 250 parts of Radix Wikstroemae, 400 parts of Rhizoma Saururi (Herba Saururi)s, mix 5-10 minute to even;

(3) take by weight 250 parts, Radix Glycyrrhizae, 300 parts of Radix Berberidis, 250 parts of Rhizoma Zingiberiss, 300 parts of Rhizoma Zingiberis Preparatums, 350 parts, Bulbus Allii, 300 parts of Rhizoma Dioscoreaes, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.

Embodiment 3

A kind of Chinese medicine composition for the treatment of avian dysentery: carry out as follows: (every part by 10g)

(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;

(2) take by weight 500 parts of Mahonia fortunei (Lindl.) Fedde, 350 parts of Flos Caryophyllis, 450 parts of Fructus Anisi Stellatis, 450 parts, catechu, 400 parts of Radix Wikstroemae, 600 parts of Rhizoma Saururi (Herba Saururi)s, mix 5-10 minute to even;

(3) take by weight 350 parts, Radix Glycyrrhizae, 450 parts of Radix Berberidis, 350 parts of Rhizoma Zingiberiss, 450 parts of Rhizoma Zingiberis Preparatums, 550 parts, Bulbus Allii, 450 parts of Rhizoma Dioscoreaes, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.

Clinical trial:

This clinical trial is only to treat Pullorum Disease more common in avian dysentery as example.

Clinical experiment animal selects 20 ages in days, body weight at 0.8kg-0.9kg, the ill broiler that Laboratory Diagnosed is Pullorum Disease.Ill chicken isolation is raised separately, the complete feed of feeding, and be divided at random 3 groups, and 100 every group, 3 groups of feeding environments are identical, and experimental period is carried out 5 days altogether; Blank group is left intact, and institute's control drug for medicine matched group " dysentery health is loose " is used treatment by its description; Chinese medicine composition group of the present invention is by product of the present invention (the prepared compositions of the embodiment of the present invention 2) the ill poultry of feeding etc., and a day dose is: by the every 100g of the present invention, spice 250kg feeds or the 400kg that drinks water, and every day 2-3 time, is used in conjunction 3-5 day; After oral, reach the object for the treatment of disease by gastrointestinal absorption.Computational methods: mortality rate=dead animal number/experimental animal number × 100%, cure rate=healing number of animals/experimental animal number × 100%.Result when following table is experiment end.

Pullorum Disease efficacy assessment standard:

Cure: spiritual normal, the drinking-water of searching for food is normal, and feces is normal, and feather is normal, breathe normally, bouncing, cuts open inspection liver, heart etc. normal, and laboratory detects and has no Pullorum Disease Salmonella etc.

When end, there is symptom: clinical symptoms is not improved even and increased the weight of.

Table is the field applicable cases contrast of the present invention and other medicines treatment Pullorum Disease:

Numbering	Group	Mortality rate %	Cure rate %	When end, there is symptom rate %
					I	Blank group	23	2	75
II	The dysentery health group of faling apart	9	79	12
					III	Present composition group	5	89	6

This clinical effectiveness statistical analysis, the loose group of present composition treatment group and dysentery health extremely significantly (P<0.01) of difference compared with aspect cure rate.

Safety testing:

Choose 60 of the healthy broiler of 20 ages in days, according to 5 times of spices of the made compositions recommended dose of the embodiment of the present invention 2 or drinking-water 5 days, during medication, healthy broiler is without any bad or Deviant Behavior performance, the drinking-water of searching for food is normal, and body weight increases that to compare difference not remarkable with blank group (being not administration of health group).

The above-mentioned detailed description that Chinese medicine composition to this treatment avian dysentery and preparation method thereof carries out with reference to embodiment; illustrative instead of determinate; can list several embodiment according to institute's limited range; therefore in the variation and the amendment that do not depart under general plotting of the present invention, within should belonging to protection scope of the present invention.

Claims (3)

1. treat a Chinese medicine composition for avian dysentery, it is characterized in that by following component by weight mixed preparing form: Mahonia fortunei (Lindl.) Fedde 25-50 part, Flos Caryophylli 15-35 part, Fructus Anisi Stellati 15-45 part, catechu 15-45 part, Radix Wikstroemae 10-40 part, Rhizoma Saururi (Herba Saururi) 15-60 part, Radix Glycyrrhizae 15-35 part, Radix Berberidis 15-45 part, Rhizoma Zingiberis 15-35 part, Rhizoma Zingiberis Preparatum 15-45 part, Bulbus Allii 15-55 part, Rhizoma Dioscoreae 15-45 part form.

2. the Chinese medicine composition for the treatment of avian dysentery according to claim 1, is characterized in that described various component optimum ratio amount is: 40 parts of Mahonia fortunei (Lindl.) Fedde, 25 parts of Flos Caryophyllis, 30 parts of Fructus Anisi Stellatis, 30 parts, catechu, 25 parts of Radix Wikstroemae, 40 parts of Rhizoma Saururi (Herba Saururi)s, 25 parts, Radix Glycyrrhizae, 30 parts of Radix Berberidis, 25 parts of Rhizoma Zingiberiss, 30 parts of Rhizoma Zingiberis Preparatums, 35 parts, Bulbus Allii, 30 parts of compositions of Rhizoma Dioscoreae.

3. a preparation method for the Chinese medicine composition for the treatment of avian dysentery according to claim 1 and 2, is characterized in that carrying out as follows:

(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;

(2) take by weight Mahonia fortunei (Lindl.) Fedde 25-50 part, Flos Caryophylli 15-35 part, Fructus Anisi Stellati 15-45 part, catechu 15-45 part, Radix Wikstroemae 10-40 part, Rhizoma Saururi (Herba Saururi) 15-60 part, mix 5-10 minute to even;

(3) take by weight Radix Glycyrrhizae 15-35 part, Radix Berberidis 15-45 part, Rhizoma Zingiberis 15-35 part, Rhizoma Zingiberis Preparatum 15-45 part, Bulbus Allii 15-55 part, Rhizoma Dioscoreae 15-45 part, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.