CN105998321A - Feed additive for treating and preventing broiler mycoplasmosis and preparation method thereof - Google Patents
Feed additive for treating and preventing broiler mycoplasmosis and preparation method thereof Download PDFInfo
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- CN105998321A CN105998321A CN201610307286.7A CN201610307286A CN105998321A CN 105998321 A CN105998321 A CN 105998321A CN 201610307286 A CN201610307286 A CN 201610307286A CN 105998321 A CN105998321 A CN 105998321A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/78—Saururaceae (Lizard's-tail family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/74—Bacteria
- A61K35/741—Probiotics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/70—Polygonaceae (Buckwheat family), e.g. spineflower or dock
- A61K36/708—Rheum (rhubarb)
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Abstract
The invention provides a feed additive for treating and preventing broiler mycoplasmosis and a preparation method thereof. The feed additive is prepared from, by weight, 70-80% of cordate houttuynia, 19-29.1% of rheum officinale, and the balance enzymes and bacteria. According to the formula, Chinese herbal medicine and beneficial enzyme flora are completed adopted, the medicine effect is outstanding, the feed additive is safe and free of toxicity, side effects are small, the immunity of a body can be enhanced, and feed digestion and absorption are promoted. The feed additive is much effective for treating broiler mycoplasma infection clinically, the material consumption and manufacturing technology is simple, and broiler growth will not be affected when pharmaceutical compositions of the medicine is adopted.
Description
Technical field
The present invention relates to a kind of feed additive treating anti-broiler mycoplasma.
Background technology
Broiler mycoplasma is high degree in contact, the chronic respiratory tract disease of infectious disease caused by mycoplasma gallinarum, major lesions
Age in days with chicken is different and changes;It is mainly in poky 1-2 monthly age chickling;The most all can occur, autumn, winter are sent out
Sick rate is higher, higher if any mortality rate during other sick mixed infections.Clinical manifestation is to infect chickling respiratory murmur, to cough, flow nose
Liquid is characterized.This disease is that poultry broods one of the principal disease in stage, is also typical through one of egg vertical transmission disease,
Also number of ways horizontal transmission can be passed through.Aviculture is particularly in the poultry in the stage of brooding very harmful.
Primary disease is distributed in countries in the world, and owing to feeding manner changes, stocking density improves, and breeding environment changes, and mycoplasma lures
The rate of sending out increases, and causes the great attention of aquaculture accordingly.The resistance of mycoplasma environment to external world is strong, leaves after chicken body quickly
Lose vigor.Can survive under the room temperature of 18~20 DEG C 6 days.The chicken manure of 200c is survived 1~3 day, in yolk 37 DEG C
Time survival 18 weeks or 20 DEG C 6 weeks.Heating is easily killed, and heats 45 DEG C and within 20 minutes, can lose virulence in 1 hour, 50 DEG C.Low temperature
Under the conditions of the time-to-live long, lose through 21 days virulence in 5 DEG C of refrigerators, at-20 DEG C, its infectiousness can keep 3 years, and-30 DEG C can
Keep 5 years as long as.Mycoplasma in the sick chicken turbinates of low-temperature freeze drying, can survive 10~14 years as long as in 4 DEG C of refrigerators,
Broth culture-60~C still can cultivate successfully after preserving 10 years.
For this disease, the most treatments based on antibacterials, as fluoroquinolones, aminoglycosides, chloromycetin,
Macrolide etc., but the therapeutic effect of its medicine is the most prominent, is still in growth and development stage because of brood time poultry again, west
Medicine is very big to its toxic and side effects, has had a strong impact on the healthy growth of poultry, and therefore research and development one treats this disease and nontoxic
The specific medicament of side effect is one of this field scientific research technical staff new problem anxious to be resolved.
The feed additive suffering from mycoplasma in prevention Spotted-brown chicken breeding process commonly used in the prior art, its Chinese medicine composition
Component and ratio of weight and number: Herba Houttuyniae 95-105g, Radix Platycodonis 95-105g, Flos Lonicerae 95-105g, Flos Chrysanthemi 95-105g,
Radix Ophiopogonis 95-105g, Radix Scutellariae 80-90g, Herba Ephedrae 80-90g, Semen Armeniacae Amarum 80-90g, Cortex Mori 80-90g, Gypsum Fibrosum 55-65g, half
Summer 95-105g, Radix Glycyrrhizae 35-45g, Ramulus Mori additive 4-6g.Wherein Ramulus Mori additive is made up of following raw material: Ramulus Mori 5g, crow
Medicine 1g, Radix Angelicae Sinensis 2g, Radix Rehmanniae 3g, Flos Osmanthi Fragrantis 2g, tea branch 1.5g, bamboo charcoal 1.5g, employing is pulverized and mixed prepared.During preparation, will
Formula material medicated powder is broken into powder, the ratio in 3% and feedstuff mixed feeding.The use time of above-mentioned formula is longer, institute
The Chinese herbal medicine needed and the large percentage of feedstuff, cause the cost in chicken farm to increase, and chicken is slow to the absorption of Chinese herbal medicine.
Summary of the invention
The shortcoming of prior art in view of the above, it is an object of the invention to provide a kind of feedstuff treating anti-broiler mycoplasma
Additive, can improve the immunity of broiler, improves the drug effect of Chinese medicine.
Another object of the present invention is to provide the preparation method of a kind of feed additive treating anti-broiler mycoplasma.
For achieving the above object and other relevant purposes, the embodiment of the present invention provides a kind of feedstuff treating anti-broiler mycoplasma to add
Add agent, divide including following weight array: Herba Houttuyniae 70-80%, Radix Et Rhizoma Rhei 19-29.1%, remaining composition are enzyme and bacterium.
Preferably, described bacterium is photosynthetic bacteria, and the weight number of described photosynthetic bacteria is 0.1-0.2%.
Preferably, described enzyme is cellulase and the combination of xylanase or a kind of enzyme therein.
Preferably, the weight number of described cellulase is 0.1%-0.4%, and the weight number of xylanase is 0.1%-0.4%.
Preferably, its formula includes that following weight array is divided: Herba Houttuyniae 75%, Radix Et Rhizoma Rhei 24.3%, cellulase 0.3%, xylan
Enzyme 0.3%, photosynthetic bacteria 0.1%.
Preferably, its formula includes that following weight array is divided: Herba Houttuyniae 78.5%, Radix Et Rhizoma Rhei 21%, cellulase 0.4%, photosynthetic carefully
Bacterium 0.1%.
The embodiment of the present invention also provides for the preparation method of a kind of feed additive treating anti-broiler mycoplasma, by following weight number
The Herba Houttuyniae 70-80% of component, Radix Et Rhizoma Rhei 19-29.1% pulverize, and are first crushed to 200-300 mesh, then superfine powder technique breaking cellular wall
Being crushed to 400-500 mesh, add cellulase and/or xylanase, photosynthetic bacteria, stir drying, is added by this feedstuff
Agent 1.5-3%, the ratio of feedstuff 97-98.5% carry out mixed feeding.
As it has been described above, a kind of feed additive treating anti-broiler mycoplasma of the present invention, have the advantages that
1, Chinese medicine is combined with cellulase, insoluble fibrin in medical material can be converted, improve the drug effect of Chinese medicine;
2, the Herba Houttuyniae in formula, Radix Et Rhizoma Rhei are nontoxic, will not produce drug residue;
3, add photosynthetic bacteria, can effectively suppress growth and the breeding of harmful levels of pathogens, reduce harmful levels of pathogens quantity, improve poultry
Immunity;
4, feedstuff is digested and assimilated facilitation by birds, improve efficiency of feed utilization;
5, raw material types is few, convenient sources, and hybrid mode is simple.
Detailed description of the invention
By particular specific embodiment, embodiments of the present invention being described below, those skilled in the art can be taken off by this specification
The content of dew understands other advantages and effect of the present invention easily.
Embodiment 1: Herba Houttuyniae 75%, Radix Et Rhizoma Rhei 24.3%, cellulase 0.3%, xylanase 0.3%, photosynthetic bacteria 0.1%.
Embodiment 2: Herba Houttuyniae 70%, Radix Et Rhizoma Rhei 29.1%, cellulase 0.4%, xylanase 0.4%, photosynthetic bacteria 0.1%.
Embodiment 3: Herba Houttuyniae 80%, Radix Et Rhizoma Rhei 19%, cellulase 0.4%, xylanase 0.4%, photosynthetic bacteria 0.2%.
Embodiment 4: Herba Houttuyniae 71.4%, Radix Et Rhizoma Rhei 28.1%, xylanase 0.4%, photosynthetic bacteria 0.1%.
Embodiment 5: Herba Houttuyniae 78.5%, Radix Et Rhizoma Rhei 21%, cellulase 0.4%, photosynthetic bacteria 0.1%.
Embodiment 6: Herba Houttuyniae 76%, Radix Et Rhizoma Rhei 23.6%, cellulase 0.1%, xylanase 0.1%, photosynthetic bacteria 0.2%.
The embodiment of the present invention also provides for the preparation method of a kind of feed additive treating anti-broiler mycoplasma, by following weight number
The Herba Houttuyniae 70-80% of component, Radix Et Rhizoma Rhei 19-29.1% pulverize, and are first crushed to 200-300 mesh, then superfine powder technique breaking cellular wall
Being crushed to 400-500 mesh, add cellulase and/or xylanase, photosynthetic bacteria, stir drying, is added by this feedstuff
Agent 1.5-3%, the ratio of feedstuff 97-98.5% carry out mixed feeding.
About the Chinese medicine mentioned in formula, Herba Houttuyniae: also referred to as Herba Houttuyniae, Cor Canitis grass, belong to Saururus chinensis section, rub broken bearing the odor of fish with the hands
Taste.With controlling lung abscess vomiting pus, expectorant dyspnea of heat type is coughed, can heat-clearing and toxic substances removing, modern pharmacology experiment shows, this product have antibacterial, antiviral,
Improve the effect such as immunity of organisms, diuresis.
Radix Et Rhizoma Rhei: another name general, is being collectively referred to as of herbaceos perennial of multiple Polygonaceae Rheum.Purging heat and dredging bowels, removing pathogenic heat from blood and toxic substance from the body,
Eliminating blood stasis and inducing menstruation.For excess-heat constipation, stagnant stomachache, dysentery is not well, jaundice due to damp-heat, and heat in blood tells nosebleed, conjunctival congestion, pharyngeal swelling, acute appendicitis
Stomachache, carbuncle furuncle, blood stasis amenorrhea, upper gastrointestinal hemorrhage;External treatment burn due to hot liquid or fire, traumatic injury.So to treatment mycoplasma
There is good effect.
Photosynthetic bacteria: be the general name not putting the photosynthetic antibacterial of oxygen, is that a class is formed without spore energy
The gram negative bacteria of power, be a class using light as the energy, can utilize in nature under anaerobism illumination or aerobic dark condition
Organic substance, sulfide, ammonia etc. carry out photosynthetic microorganism as hydrogen donor carbon source of holding concurrently.The poisonous substance such as phenol, cyanogen is had and necessarily has
Stand and capacity of decomposition, there is stronger decomposition and inversion ability.Photosynthetic bacteria preparation also has the disease-resistant function of uniqueness, can be effective
The growth of suppression harmful levels of pathogens and breeding, reduce harmful levels of pathogens quantity, and its contained enzyme can promote that birds is to feedstuff
Digest and assimilate, improve efficiency of feed utilization.
Cellulase: be the general name of the glucogenic one group of enzyme of degraded cellulose, it is not monomeric enzyme, but plays synergism
Multicomponent enzyme system, be a kind of compound enzyme, mainly by circumscribed 1,4 beta-glucanase, Endo-β-glucanase and beta-glucosidase
Deng composition, also has the xylanase of the highest vigor.Act on cellulose and the product being derived from cellulose.Cellulase
Convert insoluble fibrin in medical material, improve the drug effect of Chinese medicine.
Xylanase: xylan is a kind of heterogeneous polysaccharide being present in plant cell wall, and xylanase is to be chosen for trichoderma,
By engineered conversion, ferment, extract and obtain.The viscosity brewageing middle material can be reduced, promote the release of active substance;Fall
Non-starch polysaccharides(nsp) in low feed-use grain, promotes absorbing of nutrient substance, thus is more easy to obtain soluble lipids composition.
The feed additive obtaining the formula of specific embodiment 1 to 6 compares with conventional feed additive of the prior art
Test.
The ill broiler that experimental animal selects 20 ages in days, Laboratory Diagnosed to be mycoplasma gallinarum disease.The isolation of ill chicken is individually raised,
The feedstuff treating the prior art mentioned in the feed additive of anti-broiler mycoplasma and background technology feeding the present invention adds
Agent, and it is randomly divided into 8 groups, often group 100,8 groups of feeding environments are identical, and experimental period is carried out 5 days altogether;Infect not
Treatment group is left intact as blank group, and drug control group institute's control drug is used according to an instruction treatment;This
Bright Chinese medicine composition group by the product ill poultry of feeding of the present invention etc., day dose be: by the present composition with feedstuff by 1.5-3%
Mixing, every day 2-3 time, is used in conjunction 5-6 day.Reach to treat the purpose of disease by gastrointestinal absorption after Kou Fu.Computational methods:
Mortality rate=dead animal number/experimental animal number × 100%, cure rate=healing number of animals/experimental animal number × 100%, effectively
Rate: the state of an illness after off-test, appetite, clinical symptoms have taken a turn for the better and the chicken that recovers to fall ill normally accounts for this group and always falls ill the ratio of chicken.
Following table is the result at the end of experiment.
Efficacy assessment standard: cure: spirit is normal, drinking-water of searching for food is normal, and feces is normal, breathes normal, and body temperature is normal.
Cuing open the histoorgans such as detector tube, bronchus, larynx, lungs normal, test in laboratory has no pathogenic microorganism mycoplasma.
At the end of have symptom: clinical symptoms is not improved and is even increased the weight of.
The applicable cases contrast that the table present composition is sick with other medicines treatment mycoplasma gallinarum:
Choose 20 age in days health broiler 60, according to 5 times of spices of the present invention made compositions recommended dose, during medication,
Healthy broiler does not has any bad or Deviant Behavior performance, and drinking-water of searching for food is normal, and (i.e. health is not given with blank group in body weight increase
Medicine group) to compare difference the most notable.
As it has been described above, a kind of feed additive treating anti-broiler mycoplasma that the present invention provides, this formula uses medium-height grass completely
Medicine and useful enzyme flora, drug effect is remarkable, safety non-toxic, and side effect is little, and can the immunologic function of enhancing body, promote feedstuff
Digest and assimilate.Treatment broiler mycoplasma infection is very effective clinically, and materials and processing technology are simply, is using
Growth of meat chicken is not interfered with during drug regimen of the present invention.So, the present invention effectively overcomes various shortcoming of the prior art and has
High industrial utilization.
The principle of above-described embodiment only illustrative present invention and effect thereof, not for limiting the present invention.Any it is familiar with this skill
Above-described embodiment all can be modified under the spirit and the scope of the present invention or change by the personage of art.Therefore, such as
All that in art, tool usually intellectual is completed under without departing from disclosed spirit and technological thought etc.
Effect is modified or changes, and must be contained by the claim of the present invention.
Claims (7)
1. the feed additive treating anti-broiler mycoplasma, it is characterised in that: include that following weight array is divided: Herba Houttuyniae 70-80%,
Radix Et Rhizoma Rhei 19-29.1%, remaining composition are enzyme and bacterium.
A kind of feed additive treating anti-broiler mycoplasma the most according to claim 1, it is characterised in that: described bacterium is light
Closing antibacterial, the weight number of described photosynthetic bacteria is 0.1-0.2%.
A kind of feed additive treating anti-broiler mycoplasma the most according to claim 1, it is characterised in that: described enzyme is
Cellulase and the combination of xylanase or a kind of enzyme therein.
A kind of feed additive treating anti-broiler mycoplasma the most according to claim 3, it is characterised in that: described fiber
The weight number of element enzyme is 0.1%-0.4%, and the weight number of xylanase is 0.1%-0.4%.
A kind of feed additive treating anti-broiler mycoplasma the most according to claim 4, it is characterised in that: its formula includes
Following weight array is divided: Herba Houttuyniae 75%, Radix Et Rhizoma Rhei 24.3%, cellulase 0.3%, xylanase 0.3%, photosynthetic bacteria 0.1%.
A kind of feed additive treating anti-broiler mycoplasma the most according to claim 3, it is characterised in that: its formula bag
Include following weight array to divide: Herba Houttuyniae 78.5%, Radix Et Rhizoma Rhei 21%, cellulase 0.4%, photosynthetic bacteria 0.1%.
7. the preparation method of the feed additive treating anti-broiler mycoplasma, it is characterised in that: the fish that following weight array is divided
Raw meat grass 70-80%, Radix Et Rhizoma Rhei 19-29.1% pulverize, and are first crushed to 200-300 mesh, then superfine powder technique wall breaking pulverization
To 400-500 mesh, adding cellulase and/or xylanase, photosynthetic bacteria, stir drying, by this feed additive
1.5-3%, the ratio of feedstuff 97-98.5% carry out mixed feeding.
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN111543541A (en) * | 2020-04-15 | 2020-08-18 | 山西中医药大学 | Poultry feed additive prepared from chicken manure bacteria fermented scutellaria baicalensis stem and leaf water decoction dregs and preparation method and application thereof |
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Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
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CN111543541A (en) * | 2020-04-15 | 2020-08-18 | 山西中医药大学 | Poultry feed additive prepared from chicken manure bacteria fermented scutellaria baicalensis stem and leaf water decoction dregs and preparation method and application thereof |
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