CN111184666A

CN111184666A - Antiviral urea cream compound preparation

Info

Publication number: CN111184666A
Application number: CN202010102412.1A
Authority: CN
Inventors: 董达科; 王国华
Original assignee: Nantong University; Affiliated Hospital of Jiangnan University
Current assignee: Nantong University; Affiliated Hospital of Jiangsu University; Affiliated Hospital of Jiangnan University
Priority date: 2020-02-19
Filing date: 2020-02-19
Publication date: 2020-05-22

Abstract

The invention discloses a novel antiviral urea cream compound preparation, which is used for moisturizing hand skin of the general public, in particular to clinical medical staff working at the epidemic prevention and disease treatment line and preventing virus infection. The invention takes urea, interferon and rhubarb as main components, and adds other matrixes simultaneously, and the antiviral urea cream compound preparation with stable process, exact curative effect and good safety is prepared by experimental screening and preparation. The antiviral urea cream compound preparation is used as hand cream for external use on hand skin, can play double roles of skin care and virus prevention, and greatly reduces the possibility of infection and transmission of various viruses through the hand skin.

Description

Antiviral urea cream compound preparation

Technical Field

The invention belongs to the technical field of medicines, and particularly relates to an antiviral urea cream compound preparation.

Background

The skin is the largest external organ of the human body and has an important barrier protection effect. The hand is the most easily exposed part, the skin of the hand can contact various substances every day, because cleaning needs to be carried out for many times every day, particularly, strict hand hygiene operation is needed for medical staff working at the front line of clinic, but the skin of the hand is easy to dry, desquamate and even chap after long-term and many times of cleaning, the appearance is not only influenced, but also the barrier protection effect of the skin is seriously damaged, and the invasion of various pathogens is easily caused. Currently, China is in a special stage of resisting novel coronavirus pneumonia, a large number of front-line medical staff have obvious rough and dry skin after extremely strict hand hygiene operations every day due to protection requirements, and the external hand cream is urgently needed to improve and restore the barrier function of hand skin. In the 'novel pneumonia diagnosis and treatment scheme for coronavirus infection' published by the national Weijian Commission, respiratory droplets and contact transmission are clearly pointed out as main transmission paths for the transmission paths of viruses, so that except that a mask is worn to prevent the respiratory transmission, a novel skin moisturizer which has the effects of moisturizing the skin and preventing viruses is developed and matched with the cleaning and disinfection of the skin to carry out skin care, and the possibility of contact transmission can be better avoided. For a wide range of people, the hand cream with the double functions of skin care and virus prevention is applied for daily care, and the possibility of infecting and spreading various viruses through the skin of hands can be greatly reduced. However, through literature search, at present, no antiviral urea cream compound preparation type hand cream or skin lotion with double functions of skin care and virus prevention exists at home and abroad. Therefore, the novel antiviral urea cream compound preparation has very important clinical value, social value and economic value for clinical medical staff and epidemic prevention needs of the general public.

Disclosure of Invention

Aiming at the defects of the prior art, the invention aims to provide an antiviral urea cream compound preparation which can be used for moistening hand skin and has an important function of effectively preventing virus infection for the broad public, particularly clinical medical staff working at the first line of epidemic prevention and treatment.

In order to achieve the purpose, the invention adopts the following technical scheme:

the antiviral urea cream compound preparation is prepared from an oil phase and a water phase, wherein the oil phase comprises: 110-120 g of stearic acid, 50-150 g of liquid paraffin, 0-15 g of lanolin and 0-20 g of vaseline; the aqueous phase comprises: 110-150 g of urea, 100-300 ten thousand IU of interferon, 100-200 mg of rhubarb extract, 15-20 g of triethanolamine, 30-60 g of glycerol and distilled water with constant volume of 1000 mL.

The preparation method of the composite preparation comprises the following steps: heating the oil phase component in water bath to melt and keep the temperature at 65-80 ℃, heating the water phase component in water bath to dissolve, keeping the temperature at 65-80 ℃, slowly adding the water phase into the oil phase, and continuously stirring in the same direction to obtain the semisolid substance.

The antiviral urea cream compound preparation is used as hand cream for the general public, in particular to hand skin moisturizing and virus infection prevention of clinical medical staff working at the first line of epidemic prevention and disease treatment. The main components of the antiviral urea cream compound preparation type hand cream prepared by the invention are urea, interferon and a Chinese medicinal rhubarb extract. Wherein the urea is capable of increasing the hydration of the stratum corneum of the skin and softening the skin. Interferon has broad-spectrum antiviral, antitumor and immunoregulatory effects, and its therapeutic effect is well-known by clinical scientists at home and abroad. The Chinese medicine rhubarb extract has powerful anti-infection, antisenility and antioxidant functions, and has the functions of regulating immunity, resisting inflammation, clearing away heat and toxic material, resisting pathogenic microbe, etc. the Chinese patent shows that rhubarb has the function of inhibiting influenza virus, SARS virus, herpes virus and other viruses. The invention takes urea, interferon and rhubarb as main components, and adds other matrixes simultaneously, and the antiviral urea cream compound preparation with stable process, exact curative effect and good safety is prepared by experimental screening and preparation. The anti-virus urea cream compound preparation type hand cream can play double roles of skin care and virus prevention when being externally applied to hand skin, and greatly reduces the possibility of infecting and spreading various viruses through the hand skin.

Compared with the traditional hand cream, the hand cream has the following beneficial effects:

1. the hand washing liquid has the double functions of skin care and virus prevention, reduces the influence on the damage of the barrier function of the hand skin after repeated hand washing, and greatly reduces the possibility of transmitting various viruses through hand contact.

2. Before wearing the protective tool, clinical first-line medical staff can be coated on the part of the skin, so that a layer of lipid film is formed on the surface of the skin, the skin is protected, the friction is reduced, the excessive hydration is prevented, sweat and possible virus invasion are isolated, and a better protective effect is achieved.

3. Can effectively enhance the protection requirements of medical staff and the common people, especially in the special period of the prior art for resisting the novel coronavirus pneumonia.

4. Can be used as health skin care product, or topical medicine.

5. The preparation process is simple, the price is low, and the method is suitable for large-scale popularization.

Detailed Description

The following examples further illustrate the present invention but are not to be construed as limiting the invention. Modifications or substitutions to methods, procedures, or conditions of the invention may be made without departing from the spirit and scope of the invention. The experimental methods and reagents of the formulations not specified in the examples are in accordance with the conventional conditions in the art.

Example 1

The prescription composition is as follows: the oil phase of the product is: 110g of stearic acid, 70g of liquid paraffin and 20g of vaseline; the water phase comprises 110g of urea, 200 ten thousand IU of interferon, 150mg of rhubarb extract, 18g of triethanolamine, 60g of glycerol and distilled water with constant volume of 1000 ml. Making into oil-in-water cream.

Preparation: and (3) putting the oil phase component into a proper container to be heated in a water bath to melt and keep the temperature at about 65-80 ℃, putting the water phase component into another beaker to be heated in a water bath to dissolve, keeping the temperature at about 65-80 ℃, slowly adding the water phase into the oil phase, and continuously stirring in the same direction to obtain a semi-solid substance.

Example 2

The prescription composition is as follows: the oil phase of the product is: 115g of stearic acid, 150g of liquid paraffin and 15g of lanolin; the water phase comprises 140g of urea, 300 ten thousand IU of interferon, 100mg of rhubarb extract, 18g of triethanolamine, 40g of glycerol and distilled water with constant volume of 1000 ml. Making into oil-in-water cream.

Example 3

The prescription composition is as follows: the oil phase of the product is: 115g of stearic acid, 120g of liquid paraffin and 15g of vaseline; the water phase comprises 140g of urea, 300 ten thousand IU of interferon, 120mg of rhubarb extract, 18g of triethanolamine, 45g of glycerol and distilled water with constant volume of 1000 ml. Making into oil-in-water cream.

The prepared hand cream was evaluated for efficacy and safety as follows:

1. and (4) checking the quality of a finished product:

(1) general examination: appropriate amount of each of 3 batches of finished products was taken and checked for appearance, spreadability, greasiness, etc. The result shows that the finished product has fine appearance, smooth hand feeling, easy unfolding after external coating, no grain feeling and no layering phenomenon.

(2) And (4) checking the stability: taking 3 batches of finished products, uniformly filling the finished products into a closed container, respectively placing the finished products in a thermostat, at room temperature (25 +/-3) DEG C and in a refrigerator (5 +/-2) DEG C for one month, and checking results show that the finished products have no obvious changes in consistency, color, uniformity and the like and have no phenomena of mildew and the like.

(3) Moisture retention test: white paper is cut into a certain size, a layer of antiviral urea cream compound preparation sample is uniformly coated after precise weighing, the sample is weighed, and the sample is taken out and weighed after being placed at 25 +/-l ℃ for 4 hours without obvious change, so that the moisturizing performance of the antiviral urea cream compound preparation is proved to be better.

2. Determination of interferon biological activity: a micro cytopathic inhibition method (CPE) is adopted, WISH cells/VSV virus is used as a basic detection system, and the calibration is IU by using national reference products. The measured result shows that the potency of 3 batches of finished products meets the biological activity of 2.0 multiplied by 10⁴IU/g or above.

3. Skin irritation test: adult rabbits were selected as 12 animals and randomly divided into 4 groups of 3 animals, 3 test groups and 1 vehicle group. The animals in the experimental group were administered 0.5g of the antiviral urea cream complex formulation applied to the skin of the backs of the dehaired rabbits (2.5 cm)²) After 24h, redness, blistering, congestion or other allergic phenomena were observed. Vehicle group animals were given only a base application of the antiviral urea cream complex formulation. The results showed that no local skin abnormality was observed in the test group through the skin irritation test.

Claims

1. The antiviral urea cream compound preparation is characterized in that: is prepared from an oil phase and an aqueous phase, wherein the oil phase comprises: 110-120 g of stearic acid, 50-150 g of liquid paraffin, 0-15 g of lanolin and 0-20 g of vaseline; the aqueous phase comprises: 110-150 g of urea, 100-300 ten thousand IU of interferon, 100-200 mg of rhubarb extract, 15-20 g of triethanolamine, 30-60 g of glycerol and distilled water with constant volume of 1000 mL.

2. A method for producing the composite preparation according to claim 1, characterized in that: the method comprises the following steps: heating and melting the oil phase component under the water bath condition, keeping the temperature at 65-80 ℃, heating and dissolving the water phase component under the water bath condition, keeping the temperature at 65-80 ℃, slowly adding the water phase into the oil phase, and continuously stirring the mixture in the same direction to obtain the semisolid substance.

3. Use of the complex formulation of claim 1 in the preparation of a skin care product.

4. Use according to claim 3, characterized in that: the skin care product is hand cream, skin lotion, and facial skin lotion.