CN103751613B

CN103751613B - A kind of Chinese medicinal liniment treating wind heat blood-dryness type seborrheic dermatitis

Info

Publication number: CN103751613B
Application number: CN201410020766.6A
Authority: CN
Inventors: 游桂荣; 赵静; 吴晓林
Original assignee: Individual
Current assignee: Haimen Ruitai Textile Technology Co ltd
Priority date: 2014-01-12
Filing date: 2014-01-12
Publication date: 2016-06-08
Anticipated expiration: 2034-01-12
Also published as: CN103751613A

Abstract

The invention discloses a kind of Chinese medicinal liniment treating wind heat blood-dryness type seborrheic dermatitis. Seborrheic dermatitis belongs to the traditional Chinese medical science " seborrhea ichthyosis ", " seborrheic dermatitis " category. Wind heat blood-dryness type seborrheic dermatitis, due to the dry cloudy wound of blood usually, feels wind heat again, strongly fragrant for a long time then dryness-transformation, failure of skin and muscle to be nourished, even ailment said due to cold or exposure is strongly fragrant for a long time, hematozemia impairment of YIN, skin loses that to support then raw air slaking in child dry. The present invention selects Chinese medicine Herba Ainsliaeae Fragrantis, Gentiana rhodantha Franch., Herba Odontitis Serotinae, Herba Dracocephali Rupestris, Herba Apii graveolentis, Radix panici repentics, Herba Erigerontis Canadensis (Herba Conyzae Canadensis), Herba Moslae Cavaleriei, Herba dauci carotae (Fructus Dauci Carotae), liniment is made by I institute Drug Manufacturing Room, through clinical trial, total effective rate 97.7%, hence it is evident that be better than the 83.7% of matched group.

Description

A kind of Chinese medicinal liniment treating wind heat blood-dryness type seborrheic dermatitis

Technical field

The present invention relates to a kind of Chinese medicine composition, particularly relate to a kind of Chinese medicinal liniment treating wind heat blood-dryness type seborrheic dermatitis.

Background technology

Seborrheic dermatitis, also known as seborrheic eczema, is to occur at the chronic papulosquamous inflammatory dermatoses of one at the abundant position of sebaceous gland. Primary disease is more common in adult and neonate, is apt to occur in the abundant district of the sebaceous gland such as head, trunk. Its cause of disease pathogeny is unclear, it is now recognized that with the paraplasm of the microorganism such as local fungal, staphylococcus aureus and infection, the exception of patient immune function, the shortage of trace element zinc, androgen raises, and sebum secretion is vigorous, heredodiathesiies etc. are relevant, additionally psychentonia, dietary habit, vitamin B complex lacks, ring mirror factor, the many factors such as congenital skin barrier function obstacle can bring out and increase the weight of primary disease, is prone to diagnosis clinically, after treatment can symptom management, but tend to recurrence. Western medical treatment is generally adopted the treatment of the method such as sebum steroid and antifungal, androgen antagonist, antiinflammatory, but relapse rate is high, and medicament categories is few, and costly, side effect is big for price. Clinical practice for many years proves, external treatment of Chinese medicine is simple to operate, easy honest and clean effect, and easy to use, low price, curative effect is reliable. External treatment of Chinese medicine, by medicine or treatment operation, directly acts on diseased region, rapid-action, plays a role fully, and local efficacy is better than treatment by oral administration of medicines.

Summary of the invention

It is an object of the invention to provide a kind of Chinese medicinal liniment treating wind heat blood-dryness type seborrheic dermatitis. Seborrheic dermatitis belongs to the traditional Chinese medical science " seborrhea ichthyosis ", " seborrheic dermatitis " category. Wind heat blood-dryness type seborrheic dermatitis, due to the dry cloudy wound of blood usually, feels wind heat again, strongly fragrant for a long time then dryness-transformation, failure of skin and muscle to be nourished, even ailment said due to cold or exposure is strongly fragrant for a long time, hematozemia impairment of YIN, skin loses in moistening that to support then raw air slaking dry, and both reciprocal causations, so that pachylosis, show as dryness skin lesion more.

It is an object of the invention to be achieved through the following technical solutions, the Chinese medicinal liniment of this treatment wind heat blood-dryness type seborrheic dermatitis is made up of the Chinese medicine of following weight portion: Herba Ainsliaeae Fragrantis 12-16 part, Gentiana rhodantha Franch. 9-15 part, Herba Odontitis Serotinae 3-9 part, Herba Dracocephali Rupestris's 7-10 part, Herba Apii graveolentis 9-15 part, Radix panici repentics 30-40 part, Herba Erigerontis Canadensis (Herba Conyzae Canadensis) 25-35 part, Herba Moslae Cavaleriei 9-15 part, Herba dauci carotae (Fructus Dauci Carotae) 6-10 part.

Preferred: Herba Ainsliaeae Fragrantis 14 parts, Gentiana rhodantha Franch. 12 parts, Herba Odontitis Serotinae 6 parts, Herba Dracocephali Rupestris 8.5 parts, Herba Apii graveolentis 12 parts, Radix panici repentics 35 parts, Herba Erigerontis Canadensis (Herba Conyzae Canadensis) 30 parts, Herba Moslae Cavaleriei 12 parts, Herba dauci carotae (Fructus Dauci Carotae) 8 parts.

After above-mentioned Chinese crude drug is soaked 30min by preparation method, decoct 3 times, the 1st 1h, 2nd, 3 each 40min, merge 3 decocting liquids, filter, when 50 DEG C, it is 1.20 that filtrate is concentrated into relative density, adds ethanol and makes alcohol content reach 60%, stir, static 24h, leaching supernatant, reclaim ethanol, concentration is 200mL, and uses flowing steam sterilization 30min, and subpackage both obtained.

Fang Zhong: Herba Ainsliaeae Fragrantis, Gentiana rhodantha Franch. clearing away heat-damp and promoting diuresis, removing pathogenic heat from blood and toxic substance from the body; Herba Odontitis Serotinae, Herba Dracocephali Rupestris's heat clearing and damp drying, cooling blood for hemostasis; Herba Apii graveolentis heat clearing away suppressing the hyperactive liver, expelling wind and removing dampness; Radix panici repentics heat clearing away suppressing the hyperactive liver, detoxification and promoting urination; Herba Erigerontis Canadensis (Herba Conyzae Canadensis) dispelling wind for relieving itching, anthelmintic removing toxic substances; Herba Moslae Cavaleriei dispelling wind for relieving itching, counteracting toxic substances, the skin ulcer that disappears are swollen; Herba dauci carotae (Fructus Dauci Carotae) killing parasites for relieving itching, detumescence.

Clinical data

1. physical data 86 example patient is all from the medical patient of my institute, wherein male 44 example, women 42 example, 6��64 years old age, average 37.1 years old, the course of disease 1 month��9 years, average 2.2 years, being randomly divided into treatment group and matched group, two groups of patients there was no significant difference (P > 0.05) in age, sex, the course of disease, has comparability.

2. person between twenty and fifty are more common in diagnostic criteria (1), and the course of disease is chronic, recurrent exerbation, time light time weight. (2) it is apt to occur in the position rich in sebaceous gland, such as scalp, face, particularly eye, oral-nasal perimeter, throat, oxter, front etc. (3) skin lesion boundary is clear, and form is not of uniform size. From the beginning of for perifollicolar redness hillock recover, then merging in flakes, typical case's skin lesion is yellowish red color or pale red patch, and coated with greasy or dryness squama and crust, severe patient can with alopecia. (4) conscious pruritus in various degree. (5) Chinese medical discrimination disease: skin lesion is yellowish red color, dry desquamative macule, has a large amount of canescence pityrosporum sample squama at head, hair is withered to come off, and red tongue tongue is few, stringy and rolling pulse.

3. Therapeutic Method treatment group patient uses Chinese medicinal liniment of the present invention, weighs Herba Ainsliaeae Fragrantis 14g, Gentiana rhodantha Franch. 12g, Herba Odontitis Serotinae 6g, Herba Dracocephali Rupestris 8.5g, Herba Apii graveolentis 12g, Radix panici repentics 35g, Herba Erigerontis Canadensis (Herba Conyzae Canadensis) 30g, Herba Moslae Cavaleriei 12g, Herba dauci carotae (Fructus Dauci Carotae) 8g. After above Chinese crude drug soaks 30min, decoct 3 times, the 1st 1h, 2nd, 3 each 40min, merge 3 decocting liquids, filter, when 50 DEG C, it is 1.20 that filtrate is concentrated into relative density, adds ethanol and makes alcohol content reach 60%, stir, static 24h, leaching supernatant, reclaim ethanol, concentration is 200mL, and uses flowing steam sterilization 30min, and subpackage both obtained. Patient takes this product uniform application every day in affected part, massages 5 minutes, every day twice, continuous 4 weeks. Matched group patient uses Xi Ersheng (selenium sulfide lotion), new Asia, Shanghai, port Pharmaceutical (Yangzhou) company limited; The quasi-word of traditional Chinese medicines: H10890059. Hair is first drenched by patient with clear water, then smears Xi Ersheng lotion, and employing is rubbed, the method for massaging scalp, rinses with clear water after 5min. 2 times weekly, after continuous 4 weeks (8 times), carry out efficacy determination.

4. criterion of therapeutical effect (1) is cured: transference cure, skin lesion disappears completely. (2) effective: symptom substantially alleviates, skin lesion is clearly better. (3) effective: symptom, skin lesion take a favorable turn. (4) invalid: symptom, skin lesion without improvement, though or skin lesion alleviate but still have new skin lesion to occur.

5. two groups of patient treatments of therapeutic effect carry out comparitive study, treatment group 43 example after 4 weeks, wherein cure 28 examples (65.1%), 14 examples that take a turn for the better (32.6%), invalid 1 example (2.3%), total effective rate 97.7%.Matched group 43 example, wherein cures 12 examples (27.9%), 24 examples that take a turn for the better (55.8%), invalid 7 examples (16.3%), total effective rate 83.7%. Two groups are compared, and treatment group cure rate, total effective rate are substantially better than matched group, have comparability (P < 0.05).

Detailed description of the invention

Embodiment one: weigh Herba Ainsliaeae Fragrantis 14g, Gentiana rhodantha Franch. 12g, Herba Odontitis Serotinae 6g, Herba Dracocephali Rupestris 8.5g, Herba Apii graveolentis 12g, Radix panici repentics 35g, Herba Erigerontis Canadensis (Herba Conyzae Canadensis) 30g, Herba Moslae Cavaleriei 12g, Herba dauci carotae (Fructus Dauci Carotae) 8g. After above Chinese crude drug soaks 30min, decoct 3 times, the 1st 1h, 2nd, 3 each 40min, merge 3 decocting liquids, filter, when 50 DEG C, it is 1.20 that filtrate is concentrated into relative density, adds ethanol and makes alcohol content reach 60%, stir, static 24h, leaching supernatant, reclaim ethanol, concentration is 200mL, and uses flowing steam sterilization 30min, and subpackage both obtained.

Embodiment two: weighing Herba Ainsliaeae Fragrantis 16g, Gentiana rhodantha Franch. 9g, Herba Odontitis Serotinae 9g, Herba Dracocephali Rupestris 10g, Herba Apii graveolentis 15g, Radix panici repentics 30g, Herba Erigerontis Canadensis (Herba Conyzae Canadensis) 25g, Herba Moslae Cavaleriei 9g, Herba dauci carotae (Fructus Dauci Carotae) 10g, preparation method is with embodiment one.

Embodiment three: weighing Herba Ainsliaeae Fragrantis 12g, Gentiana rhodantha Franch. 15g, Herba Odontitis Serotinae 3g, Herba Dracocephali Rupestris 7g, Herba Apii graveolentis 9g, Radix panici repentics 40g, Herba Erigerontis Canadensis (Herba Conyzae Canadensis) 35g, Herba Moslae Cavaleriei 15g, Herba dauci carotae (Fructus Dauci Carotae) 6g, preparation method is with embodiment one.

Claims

1. the Chinese medicinal liniment treating wind heat blood-dryness type seborrheic dermatitis, it is characterised in that this Chinese medicinal liniment is made up of the Chinese medicine of following weight portion: Herba Ainsliaeae Fragrantis 12-16 part, Gentiana rhodantha Franch. 9-15 part, Herba Odontitis Serotinae 3-9 part, Herba Dracocephali Rupestris's 7-10 part, Herba Apii graveolentis 9-15 part, Radix panici repentics 30-40 part, Herba Erigerontis Canadensis (Herba Conyzae Canadensis) 25-35 part, Herba Moslae Cavaleriei 9-15 part, Herba dauci carotae (Fructus Dauci Carotae) 6-10 part.

2. a kind of Chinese medicinal liniment treating wind heat blood-dryness type seborrheic dermatitis as claimed in claim 1, it is characterised in that this Chinese medicinal liniment is made up of the Chinese medicine of following weight portion: Herba Ainsliaeae Fragrantis 14 parts, Gentiana rhodantha Franch. 12 parts, Herba Odontitis Serotinae 6 parts, Herba Dracocephali Rupestris 8.5 parts, Herba Apii graveolentis 12 parts, Radix panici repentics 35 parts, Herba Erigerontis Canadensis (Herba Conyzae Canadensis) 30 parts, Herba Moslae Cavaleriei 12 parts, Herba dauci carotae (Fructus Dauci Carotae) 8 parts.