CN102370968A - Compound propolis composite for treating chicken infectious laryngotracheitis and preparation method thereof - Google Patents
Compound propolis composite for treating chicken infectious laryngotracheitis and preparation method thereof Download PDFInfo
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- CN102370968A CN102370968A CN2011103068676A CN201110306867A CN102370968A CN 102370968 A CN102370968 A CN 102370968A CN 2011103068676 A CN2011103068676 A CN 2011103068676A CN 201110306867 A CN201110306867 A CN 201110306867A CN 102370968 A CN102370968 A CN 102370968A
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Abstract
The invention discloses a compound propolis composite for treating chicken infectious laryngotracheitis in the field of poultry medicine and a preparation method thereof. The compound propolis composite comprises the following ingredients. The method comprises the following steps: (1) carrying out ultramicro smashing on various ingredients (except interferon) in a formula, and screening by a screen of 700 meshes; (2) weighing 15-25 parts of propolis, 5-15 parts of interferon for pigs, 10-35 parts of honeysuckle, 15-30 parts of ephedra according to weight, and evenly mixing for 5-10 minutes; (3) weighing 10-30 parts of Scutellaria baicalensis, 10-35 parts of Platycodon grandiflorum, 10-25 parts of semen armeniacae amarae, 15-35 parts of liquorice and 10-30 parts of blackberry lily, and evenly mixing for 5-10 minutes; (4) combining the composites obtained in steps (2) and (3); and continuously and evenly mixing for 10-15 minutes. The compound propolis composite has the beneficial effect that the composite does not have toxic and side effect, is free from pollution and drug residue, does not have drug tolerance, has the advantages of ultramicro smashing and high bioavailability and has specially good effect on the chicken infectious laryngotracheitis proven by the clinical trials.
Description
Technical field
The present invention relates to fowl medicine field, bronchitic compound bee-glue composition of the avian infectious larynx of particularly a kind of treatment and preparation method thereof.
Background technology
Avian infectious larynx bronchitis is a kind of acute, the contact upper respiratory infectious disease that is caused by avian infectious larynx bronchitis virus.The chicken of various ages and kind all can infect, and it is characterized in that dyspnea, cough and expectoration contain the exudate of blood sample.Visible throat, tunica mucosa tracheae swelling, hemorrhage and rotten to the corn when cuing open inspection.Primary disease is propagated fast, and mortality rate is generally between 10%-30%.This disease all can take place throughout the year, and cold season autumn and winter is multiple, is one of principal disease of harm poultry husbandry.
The pathogen of primary disease is a herpesvirus, and virus can be survived more than 1 year under dry environment.Under cryogenic conditions, the time-to-live is long.This disease almost spreads all over all countries of raising chickens of the world, distributes very extensively.At present, treat this disease the most frequently used be Chinese medicine and antiviral Western medicine, Chinese medicine is because its prescription is unreasonable or just simple the pulverizing, and particle diameter is excessive, and drug release is slower, causes its bioavailability lower, clinical effectiveness is not fine; And the various antiviral drugs such as the Ministry of Agriculture such as ribavirin, amantadine ban use of.
Therefore researching and developing a kind of bronchitic drug residue free of avian infectious larynx, generations that have no drug resistance, the significant specific medicament of clinical effectiveness of treating is one of this field scientific research technical staff urgency new problem to be solved.
Summary of the invention
The objective of the invention is to overcome above-mentioned weak point, provide that a kind of reasonable recipe, preparation are simple, micronizing, bioavailability are high, effect obviously, have no drug resistance and the bronchitic compound bee-glue composition of the avian infectious larynx of effective treatment of drug residue and preparation method thereof.
For realizing above-mentioned purpose; The embodiment that the present invention adopted is following: the bronchitic compound bee-glue composition of the avian infectious larynx of a kind of treatment, by following component by weight mixed preparing form: propolis 15-25 part, chicken are with interferon 5-15 part, Flos Lonicerae 10-35 part, Herba Ephedrae 15-30 part, Radix Scutellariae 10-30 part, Radix Platycodonis 10-35 part, Semen Armeniacae Amarum 10-25 part, Radix Glycyrrhizae 15-35 part, Rhizoma Belamcandae 10-30 part.
Said various component optimum ratio amount is: 20 parts of propolis, chicken are with 10 parts of interferon, 20 parts of Flos Loniceraes, 20 parts in Herba Ephedrae, 20 parts of Radix Scutellariaes, 25 parts of Radix Platycodoniss, 20 parts of Semen Armeniacae Amarums, 25 parts in Radix Glycyrrhizae, 20 parts of Rhizoma Belamcandae.
A kind of method for preparing of treating the bronchitic compound bee-glue composition of avian infectious larynx, carry out as follows:
(1) the various compositions (except the interferon) in the prescription is crossed 700 mesh sieves after the micronizing respectively;
(2) take by weighing propolis 15-25 part, pig by weight with interferon 5-15 part, Flos Lonicerae 10-35 part, Herba Ephedrae 15-30 part, mix 5-10 minute to even;
(3) take by weighing Radix Scutellariae 10-30 part, Radix Platycodonis 10-35 part, Semen Armeniacae Amarum 10-25 part, Radix Glycyrrhizae 15-35 part, Rhizoma Belamcandae 10-30 part by weight, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
The medicinal property of each component is following:
Propolis: bitter, hot, cold, return spleen, stomach warp, have the function of anti-inflammation, antalgesic-antipruritic, promotion tissue regeneration, raising immunity, antiallergic oxidation, hemostasis, protection gastrointestinal mucosa.
Interferon: be a kind of broad-spectrum disease resistance toxic agent, RNA and DNA viruses are had inhibition or killing action; Can inducing apoptosis of tumour cell, thus kill tumor cell; Interferon all has immunological enhancement to humoral immunization, cellular immunization, macrophage and NK cell.
Flos Lonicerae: sweet, cold, return, lung, the heart, stomach warp, have the function of heat-clearing and toxic substances removing, dispelling wind and heat pathogens; Cure mainly epidemic febrile disease heating, anemopyretic cold, laryngopharynx swelling and pain, cough due to lung-heat, toxic-heat and blood stasis, carbuncle sore tumefacting virus etc.
Herba Ephedrae: little hardship, temperature, suffering, return lung, urinary bladder channel, have the function of the cold expelling that induces sweat, depressed lung-energy dispersing, inducing diuresis to remove edema; Cure mainly affection of exogenous wind-cold, cough, asthma, edema etc.
Radix Platycodonis: bitter, hot, flat, return lung meridian, have lung qi dispersing, eliminate the phlegm, the function of sore-throat relieving, evacuation of pus; Cure mainly cough with copious phlegm, laryngopharynx swelling and pain lung abscess etc.
Radix Scutellariae: bitter, cold, return lung, gallbladder, spleen, large intestine, small intestine meridian, have heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive function; Cure mainly that cough due to lung-heat, gastrointestinal are damp and hot, dysentery, jaundice, hyperpyrexia are greedyly drunk, have blood in stool, epistaxis, conjunctival congestion and swelling pain, carbuncle sore tumefacting virus, frequent fetal movement etc.
Radix Glycyrrhizae: sweet, flat, return lung, the heart, spleen channel, have invigorating the spleen and replenishing QI, expelling phlegm for arresting cough and middle emergency, detoxifcation, coordinating the actions of various ingredients in a prescription, cushion toxicity, strong function; Cure mainly weakness of the spleen and stomach, cough with asthma, poisoning etc.
Rhizoma Belamcandae: bitter, cold, return lung meridian, have the function of heat-clearing and toxic substances removing, expectorant, sore-throat relieving; Cure mainly cough due to lung-heat, laryngopharynx swelling and pain, accumulation and obstruction of sputum etc.
Semen Armeniacae Amarum: bitter, tepor, return lung, large intestine channel, have the function of relieving cough and asthma, loosening bowel to relieve constipation; Cure mainly cough and asthma, dryness of the intestine constipation etc.
More than all flavor Chinese medicine according to the Chinese medical theory compatible combination, to the bronchitic pathogenic microorganism of avian infectious larynx and clinical symptoms and pathological change, bring into play the effect of treating both the principal and secondary aspects of a disease.
The invention has the beneficial effects as follows: reasonable recipe, preparation is simple, and substep mixes more even; Chinese medicine composition is pollution-free, no drug residue, have no drug resistance, and cost is low, and it is wide to draw materials, and micronizing, bioavailability are high, can also can drink water the curative effect highly significant by spice.The present invention is according to Chinese veterinarian's traditional theory; Optimize this seven flavors Chinese medicine, and make them form pure Chinese powder medicine according to optimum ratio, clinical practice proves; To treating avian infectious larynx bronchitis specially good effect is arranged; And make its product meat reach nuisanceless requirement, satisfy the export standard of product, guaranteed that effectively people's is healthy.
The specific embodiment
Below in conjunction with preferred embodiment, to details are as follows according to the specific embodiment provided by the invention:
Embodiment 1
Bronchitic compound bee-glue composition of the avian infectious larynx of a kind of treatment and preparation method thereof: carry out as follows: (every part by 10g)
(1) the various compositions (except the interferon) in the prescription is crossed 700 mesh sieves after the micronizing respectively;
(2) take by weighing 150 parts of propolis, pig by weight with 50 parts of interferon, 100 parts of Flos Loniceraes, 150 parts in Herba Ephedrae, mix 5-10 minute to even;
(3) take by weighing 100 parts of Radix Scutellariaes, 100 parts of Radix Platycodoniss, 100 parts of Semen Armeniacae Amarums, 150 parts in Radix Glycyrrhizae, 100 parts of Rhizoma Belamcandae by weight, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Embodiment 2
Bronchitic compound bee-glue composition of the avian infectious larynx of a kind of treatment and preparation method thereof: carry out as follows: (every part by 10g)
(1) the various compositions (except the interferon) in the prescription is crossed 700 mesh sieves after the micronizing respectively;
(2) take by weighing 200 parts of propolis, pig by weight with 100 parts of interferon, 200 parts of Flos Loniceraes, 200 parts in Herba Ephedrae, mix 5-10 minute to even;
(3) take by weighing 200 parts of Radix Scutellariaes, 200 parts of Radix Platycodoniss, 150 parts of Semen Armeniacae Amarums, 200 parts in Radix Glycyrrhizae, 200 parts of Rhizoma Belamcandae by weight, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Embodiment 3
Bronchitic compound bee-glue composition of the avian infectious larynx of a kind of treatment and preparation method thereof: carry out as follows: (every part by 10g)
(1) the various compositions (except the interferon) in the prescription is crossed 700 mesh sieves after the micronizing respectively;
(2) take by weighing 250 parts of propolis, pig by weight with 150 parts of interferon, 350 parts of Flos Loniceraes, 300 parts in Herba Ephedrae, mix 5-10 minute to even;
(3) take by weighing 300 parts of Radix Scutellariaes, 350 parts of Radix Platycodoniss, 250 parts of Semen Armeniacae Amarums, 350 parts in Radix Glycyrrhizae, 300 parts of Rhizoma Belamcandae by weight, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Clinical trial:
With the ill poultry of product feeding of the present invention etc., a day dose is: by the every 100g of the present invention, spice 150kg feeds, drinking-water 240kg, every day 2-3 time, logotype 3-5 day; Oral back reaches the purpose of treatment disease through gastrointestinal absorption.
Table is that the present invention and other medicines are treated the applicable cases contrast of the bronchitic field of avian infectious larynx:
| Numbering | Group | Mortality rate % | Cure rate % | Symptom rate % is arranged during end |
| I | The blank group | 26.6 | 32.2 | 41.2 |
| II | The HOUYANJING SAN group | 8.3 | 79.0 | 12.7 |
| III | Chinese medicine composition of the present invention | 5.2 | 90.1 | 4.7 |
This clinical effectiveness is through statistical analysis, and present composition treatment group is being compared difference extremely significantly (P＜0.01) with the HOUYANJING SAN group aspect the cure rate.
Above-mentionedly this is treated the detailed description that bronchitic compound bee-glue composition of avian infectious larynx and preparation method thereof carries out with reference to embodiment; Be illustrative rather than determinate; Can enumerate out several embodiment according to institute's limited range; Therefore in the variation and the modification that do not break away under the general plotting of the present invention, should belong within protection scope of the present invention.
Claims (3)
1. treatment avian infectious larynx bronchitic compound bee-glue composition, it is characterized in that by following component by weight mixed preparing form: propolis 15-25 part, chicken are with interferon 5-15 part, Flos Lonicerae 10-35 part, Herba Ephedrae 15-30 part, Radix Scutellariae 10-30 part, Radix Platycodonis 10-35 part, Semen Armeniacae Amarum 10-25 part, Radix Glycyrrhizae 15-35 part, Rhizoma Belamcandae 10-30 part.
2. the bronchitic compound bee-glue composition of the avian infectious larynx of a kind of treatment according to claim 1, it is characterized in that said various component optimum ratio amount is: 20 parts of propolis, chicken are with 10 parts of interferon, 20 parts of Flos Loniceraes, 20 parts in Herba Ephedrae, 20 parts of Radix Scutellariaes, 25 parts of Radix Platycodoniss, 20 parts of Semen Armeniacae Amarums, 25 parts in Radix Glycyrrhizae, 20 parts of Rhizoma Belamcandae.
3. the method for preparing of the bronchitic compound bee-glue composition of the avian infectious larynx of treatment according to claim 1 and 2 is characterized in that carrying out as follows:
(1) the various compositions (except the interferon) in the prescription is crossed 700 mesh sieves after the micronizing respectively;
(2) take by weighing propolis 15-25 part, pig by weight with interferon 5-15 part, Flos Lonicerae 10-35 part, Herba Ephedrae 15-30 part, mix 5-10 minute to even;
(3) take by weighing Radix Scutellariae 10-30 part, Radix Platycodonis 10-35 part, Semen Armeniacae Amarum 10-25 part, Radix Glycyrrhizae 15-35 part, Rhizoma Belamcandae 10-30 part by weight, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
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| Application Number | Priority Date | Filing Date | Title |
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| CN201110306867.6A CN102370968B (en) | 2011-10-12 | 2011-10-12 | Compound propolis composite for treating chicken infectious laryngotracheitis and preparation method thereof |
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| CN201110306867.6A CN102370968B (en) | 2011-10-12 | 2011-10-12 | Compound propolis composite for treating chicken infectious laryngotracheitis and preparation method thereof |
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| CN102370968A true CN102370968A (en) | 2012-03-14 |
| CN102370968B CN102370968B (en) | 2014-05-28 |
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106729619A (en) * | 2016-12-13 | 2017-05-31 | 郑州赛科药业科技有限公司 | A kind of compound preparation for treating chicken bronchial blocking and preparation method thereof |
| CN106943519A (en) * | 2016-01-06 | 2017-07-14 | 天津嘉创生物科技有限公司 | Treat Chinese and Western medicine compound mixture of chicken cough and asthma and preparation method thereof |
| CN109172807A (en) * | 2018-09-30 | 2019-01-11 | 河南黑马动物药业有限公司 | One breeder antiviral oral liquor and preparation method thereof |
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| CN1689586A (en) * | 2004-04-20 | 2005-11-02 | 成都思摩纳米技术有限公司 | Application of nano propolis in resistance of influenza virus, respiratory syncytial virus and bird infected bronchitis virus |
| CN101259160A (en) * | 2008-04-18 | 2008-09-10 | 天津生机集团股份有限公司 | Compound preparations for treating birdsvirosis and preparation thereof |
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- 2011-10-12 CN CN201110306867.6A patent/CN102370968B/en not_active Expired - Fee Related
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN1689586A (en) * | 2004-04-20 | 2005-11-02 | 成都思摩纳米技术有限公司 | Application of nano propolis in resistance of influenza virus, respiratory syncytial virus and bird infected bronchitis virus |
| CN101259160A (en) * | 2008-04-18 | 2008-09-10 | 天津生机集团股份有限公司 | Compound preparations for treating birdsvirosis and preparation thereof |
Non-Patent Citations (2)
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Cited By (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106943519A (en) * | 2016-01-06 | 2017-07-14 | 天津嘉创生物科技有限公司 | Treat Chinese and Western medicine compound mixture of chicken cough and asthma and preparation method thereof |
| CN106729619A (en) * | 2016-12-13 | 2017-05-31 | 郑州赛科药业科技有限公司 | A kind of compound preparation for treating chicken bronchial blocking and preparation method thereof |
| CN109172807A (en) * | 2018-09-30 | 2019-01-11 | 河南黑马动物药业有限公司 | One breeder antiviral oral liquor and preparation method thereof |
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| CN102370968B (en) | 2014-05-28 |
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