CN102430114B - Compound propolis composition for treating porcine parvovirus disease and preparation method thereof - Google Patents

Abstract

The invention discloses a compound propolis composition for treating porcine parvovirus disease and a preparation method thereof, and relates to the field of medicines for treating animal diseases. The preparation method comprises the following steps of: (1) performing ultrafine grinding on various components (except interferon) in a prescription, and sieving by using a 70-mesh screen; (2) weighing 15 to 25 weight parts of propolis, 5 to 15 weight parts of porcine interferon, 10 to 35 weight parts of indigowoad root and 15 to 40 weight parts of astragalus, and uniformly mixing for 5 to 10 minutes; (3) weighing 10 to 40 weight parts of baical skullcap root, 10 to 35 weight parts of honeysuckle flower, 10 to 35 weight parts of Himalayan teasel root, 15 to 35 weight parts of round cardamom and 15 to 35 weight parts of ginger, and uniformly mixing for 5 to 10 minutes; and (4) mixing compositions obtained in the steps (2) and (3), and continuously uniformly mixing for 10 to 15 minutes. Thecomposition has the advantages that: the prescription is reasonable; the composition is easy to prepare, does not have any toxic or side effect, is pollution-free, does not have medicine residue or medicine resistance, is subjected to ultrafine grinding, and has high bioavailability and an obvious curative effect; and clinical tests prove that the composition has a special effect of treating porcine parvovirus disease.

Description

A kind of compound bee-glue composition for the treatment of porcine parvovirus and preparation method thereof

Technical field

The present invention relates to treat the animal field of medicaments, particularly a kind of compound bee-glue composition that is specifically designed to the treatment porcine parvovirus and preparation method thereof.

Background technology

Porcine parvovirus is a kind of hyperinfection disease that is caused by porcine parvovirus virus, often can cause the sow breeding difficulty, and to produce stillborn fetus, mummy tire etc. as main, the sow abortion ratio can reach 50%～70%, and mortality rate can reach 10%-25%; And piglet, growing and fattening pigs and breeding boar do not show clinical symptoms usually.Primary disease all can occur throughout the year, is one of principal disease of harm pig industry.

The pathogen of primary disease is porcine parvovirus virus, and this disease almost spreads all over all countries of raising pigs of the world, is widely distributed.At present, treat this disease the most frequently used be Chinese medicine and antiviral Western medicine, Chinese medicine is because its prescription is unreasonable or simple pulverizing the just, and particle diameter is excessive, and drug release is slower, causes its bioavailability lower, clinical effectiveness is not fine; And various antiviral agents such as the Ministry of Agriculture such as ribavirin, amantadine ban use of.

Therefore research and develop and a kind ofly treat the drug residue free of porcine parvovirus, the specific medicament that produces that has no drug resistance is one of this field scientific research technical staff new problem anxious to be resolved.

Summary of the invention

The object of the invention is to overcome above-mentioned weak point, provide that a kind of reasonable recipe, preparation are simple, micronizing, bioavailability height, successful, have no drug resistance and the compound bee-glue composition of effective treatment porcine parvovirus of drug residue and preparation method thereof.

Implementation of the present invention is as follows for achieving the above object: a kind of compound bee-glue composition for the treatment of porcine parvovirus, by following component by weight mixed preparing form: propolis 15-25 part, pig are with interferon 5-15 part, Radix Isatidis 10-35 part, Radix Astragali 15-40 part, Radix Scutellariae 10-40 part, Flos Lonicerae 10-35 part, Radix Dipsaci 10-35 part, Fructus Amomi Rotundus 15-35 part, Rhizoma Zingiberis Recens 15-35 part.

On the basis of such scheme, described various component optimum ratio amounts are: 20 parts of propolis, 10 parts of interferon of pig, 25 parts of Radix Isatidis, 30 parts of the Radixs Astragali, 25 parts of Radix Scutellariaes, 25 parts of Flos Loniceraes, 25 parts of Radix Dipsacis, 20 parts in Fructus Amomi Rotundus, 25 parts in Rhizoma Zingiberis Recens.

A kind of preparation method for the treatment of the compound bee-glue composition of porcine parvovirus, carry out as follows:

(1) the various compositions (except the interferon) in the prescription is crossed 700 mesh sieves after the micronizing respectively;

(2) take by weighing by weight propolis 15-25 part, pig with interferon 5-15 part, Radix Isatidis 10-35 part, Radix Astragali 15-40 part, mix 5-10 minute to even;

(3) take by weighing by weight Radix Scutellariae 10-40 part, Flos Lonicerae 10-35 part, Radix Dipsaci 10-35 part, Fructus Amomi Rotundus 15-35 part, Rhizoma Zingiberis Recens 15-35 part, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.

The medicinal property of each component is as follows:

Propolis: bitter, hot, cold, return spleen, stomach warp, have the function of anti-inflammation, antalgesic-antipruritic, promotion tissue regeneration, raising immunity, antiallergic oxidation, hemostasis, protection gastrointestinal mucosa.

Interferon: be a kind of broad-spectrum disease resistance toxic agent, RNA and DNA viruses are had inhibition or killing action; Can inducing apoptosis of tumour cell, thus killing off tumor cells; Interferon all has immunological enhancement to humoral immunization, cellular immunization, macrophage and NK cell.

Radix Isatidis: bitter, cold, GUIXIN, stomach warp have the function of heat-clearing and toxic substances removing, removing heat from blood sore-throat relieving; Cure mainly anemopyretic cold, laryngopharynx swelling and pain, aphtha of the mouth and tongue, skin ulcer general edema with yellowish skin poison etc.

The Radix Astragali: sweet, tepor, return spleen, lung meridian, have the function of tonifying Qi and lifting yang, strengthening superficial resistance to stop perspiration, inducing diuresis to remove edema, expelling pus and toxin by strengthening QI, expelling pus and promoting granulation; Curing mainly asthenia of pulmonosplenic qi, sinking of QI of middle-JIAO, exterior deficiency spontaneous perspiration, deficiency of vital energy edema, carbuncle sore difficultly bursts, bursts for a long time and do not hold back etc.

Flos Lonicerae: sweet, cold, return lung, stomach, heart channel, have the function of heat-clearing and toxic substances removing, dispelling wind and heat pathogens; Cure mainly epidemic febrile disease heating, anemopyretic cold, cough due to lung-heat, laryngopharynx swelling and pain, toxic-heat and blood stasis, breast swell and pain, carbuncle sore tumefacting virus etc.

Radix Scutellariae: bitter, cold, return lung, gallbladder, spleen, large intestine, small intestine meridian, have heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive function; Cure mainly that cough due to lung-heat, gastrointestinal are damp and hot, dysentery, jaundice, high heat are greedyly drunk, have blood in stool, epistaxis, conjunctival congestion and swelling pain, carbuncle sore tumefacting virus, frequent fetal movement etc.

Radix Dipsaci: bitter, hot, tepor, return liver, kidney channel, have that invigorating the liver and kidney, bone and muscle strengthening, continuous folding are hindered, antiabortive function; Cure mainly that deficiency of the liver and kindey, waist flaccidity are soft, winter protection arthralgia chiefly caused by damp pathogen, traumatic injury, injury of tendon and muscle fracture, frequent fetal movement etc.

Fructus Amomi Rotundus: hot, warm, return lung, spleen, stomach warp, have the function of the removing dampness of being amusing, circulation of qi promoting warming middle-JIAO, appetite-stimulating indigestion-relieving; Curing mainly spleen-cold syndrome dyspepsia, abdominal distention, inappetence, cold type of pain, vomiting, deficiency and coldness has loose bowels etc.

Rhizoma Zingiberis Recens: hot, tepor, return lung, spleen, stomach warp, have the function of the cold expelling that induces sweat, warming middle-JIAO to arrest vomiting, preventing phlegm from forming and stopping coughing; Cure mainly affection of exogenous wind-cold, gastrofrigid vomiting, cold-phlegm cough etc.

More than all flavor Chinese medicine according to the Chinese medical theory compatible combination, for pathogenic microorganism, the clinical symptoms of porcine parvovirus, the performance treating both the principal and secondary aspects of a disease effect.

The invention has the beneficial effects as follows: reasonable recipe, preparation is simple, and substep mixes more even; Chinese medicine composition is pollution-free, no drug residue, have no drug resistance, and cost is low, and it is wide to draw materials, and micronizing, bioavailability are high, the curative effect highly significant.The present invention is according to Chinese veterinarian's traditional theory, optimize this eight flavors Chinese medicine, and make them form pure Chinese powder medicine according to optimum ratio, clinical practice proves, the treatment porcine parvovirus there is specially good effect, and make its product meat reach nuisanceless requirement, satisfy the export standard of product, guaranteed that effectively people's is healthy.

The specific embodiment

Below in conjunction with preferred embodiment, to details are as follows according to the specific embodiment provided by the invention:

Embodiment 1

A kind of compound bee-glue composition for the treatment of porcine parvovirus and preparation method thereof: carry out as follows: (every part by 10g)

(1) the various compositions (except the interferon) in the prescription is crossed 700 mesh sieves after the micronizing respectively;

(2) take by weighing by weight 150 parts of propolis, pig with 50 parts of interferon, 100 parts of Radix Isatidis, 150 parts of the Radixs Astragali, mix 5-10 minute to even;

(3) take by weighing by weight 100 parts of Radix Scutellariaes, 100 parts of Flos Loniceraes, 100 parts of Radix Dipsacis, 150 parts in Fructus Amomi Rotundus, 150 parts in Rhizoma Zingiberis Recens, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.

Embodiment 2

A kind of compound bee-glue composition for the treatment of porcine parvovirus and preparation method thereof: carry out as follows: (every part by 10g)

(1) the various compositions (except the interferon) in the prescription is crossed 700 mesh sieves after the micronizing respectively;

(2) take by weighing by weight 200 parts of propolis, pig with 100 parts of interferon, 250 parts of Radix Isatidis, 250 parts of the Radixs Astragali, mix 5-10 minute to even;

(3) take by weighing by weight 250 parts of Radix Scutellariaes, 250 parts of Flos Loniceraes, 200 parts of Radix Dipsacis, 250 parts in Fructus Amomi Rotundus, 250 parts in Rhizoma Zingiberis Recens, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.

Embodiment 3

A kind of compound bee-glue composition for the treatment of porcine parvovirus and preparation method thereof: carry out as follows: (every part by 10g)

(1) the various compositions (except the interferon) in the prescription is crossed 700 mesh sieves after the micronizing respectively;

(2) take by weighing by weight 250 parts of propolis, pig with 150 parts of interferon, 350 parts of Radix Isatidis, 400 parts of the Radixs Astragali, mix 5-10 minute to even;

(3) take by weighing by weight 400 parts of Radix Scutellariaes, 350 parts of Flos Loniceraes, 350 parts of Radix Dipsacis, 350 parts in Fructus Amomi Rotundus, 350 parts in Rhizoma Zingiberis Recens, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.

Clinical trial:

With the ill pregnant pig of product feeding of the present invention etc., a day dose is: by the every 100g of the present invention, spice 150kg feeds, and drinking-water 280kg, is used in conjunction 3-5 day at every day 2-3 time; Reach the purpose for the treatment of disease after oral by gastrointestinal absorption.

Table is the field applicable cases contrast of the present invention and other medicines treatment piglet parvovirus infection:

Numbering	Group	Mortality rate %	Cure rate %	Symptom rate % is arranged during end
					Ⅰ	The blank group	12.7	47.2	40.1
Ⅱ	The loose group of pig parvoviral health	9.6	80.3	10.1
					Ⅲ	Present composition group	3.2	92.3	4.5

This clinical effectiveness statistical analysis, present composition treatment group is being compared difference extremely significantly (P＜0.01) with the loose group of pig parvoviral health aspect the cure rate.

Above-mentioned detailed description of compound bee-glue composition of this treatment porcine parvovirus and preparation method thereof being carried out with reference to embodiment; illustrative rather than determinate; can list several embodiment according to institute's limited range; therefore in the variation and the modification that do not break away under the general plotting of the present invention, should belong within protection scope of the present invention.

Claims (3)

1. compound bee-glue composition for the treatment of porcine parvovirus, it is characterized in that by following component by weight mixed preparing form: propolis 15-25 part, pig are with interferon 5-15 part, Radix Isatidis 10-35 part, Radix Astragali 15-40 part, Radix Scutellariae 10-40 part, Flos Lonicerae 10-35 part, Radix Dipsaci 10-35 part, Fructus Amomi Rotundus 15-35 part, Rhizoma Zingiberis Recens 15-35 part.

2. a kind of compound bee-glue composition for the treatment of porcine parvovirus according to claim 1, it is characterized in that by following component by weight mixed preparing form: 20 parts of propolis, pig are with 10 parts of interferon, 25 parts of Radix Isatidis, 30 parts of the Radixs Astragali, 25 parts of Radix Scutellariaes, 25 parts of Flos Loniceraes, 25 parts of Radix Dipsacis, 20 parts in Fructus Amomi Rotundus, 25 parts in Rhizoma Zingiberis Recens.

3. the preparation method of the compound bee-glue composition of a treatment porcine parvovirus according to claim 1 is characterized in that carrying out as follows:

(1) the various compositions except interferon in the prescription is crossed 700 mesh sieves after the micronizing respectively;

(2) take by weighing by weight propolis 15-25 part, pig with interferon 5-15 part, Radix Isatidis 10-35 part, Radix Astragali 15-40 part, mix 5-10 minute to even;

(3) take by weighing by weight Radix Scutellariae 10-40 part, Flos Lonicerae 10-35 part, Radix Dipsaci 10-35 part, Fructus Amomi Rotundus 15-35 part, Rhizoma Zingiberis Recens 15-35 part, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.