CN102430113B - Compound propolis composition for treating porcine pseudorabies and preparation method thereof - Google Patents

Abstract

The invention provides a compound propolis composition for treating porcine pseudorabies and a preparation method thereof, and relates to the field of animal medicines. The preparation method provided by the invention comprises the following steps: (1) micronizing each component except interferon in the prescription respectively, and screening through a 700-mesh screen; (2) weighing 15 to 35 parts of propolis, 10 to 20 parts of porcine interferon, 15 to 45 parts of astragalus mongholicus, 15 to 35 parts of isatis root and 10 to 45 parts of gastrodia elata according to weight proportion, and mixing for 5 to 10 minutes until the mixture is uniform; (3) weighing 10 to 35 parts of humifuse euphorbia herb, 10 to 35 parts of houttuynia cordata, 15 to 35 parts of barbed skull cap herb, 15 to 35 parts of fructus forsythiae and 15 to 35 parts of toad according to the weight proportion, and mixing for 5 to 10 minutes until the mixture is uniform; and (4) combining compositions prepared in step (2) and step (3), and continuing mixing for 10 to 15 minutes until the mixture is uniform. The compound propolis composition provided by the invention has the advantages that: the components are reasonable, and the preparation is easy; the composition has no toxic or side effect, no pollution, no medicinal residues, no drug resistance, micronization, high bioavailability and remarkable curative effect; and the clinical application proves that the composition has special effect in treating porcine pseudorabies.

Description

A kind of compound bee-glue composition for the treatment of porcine pseudorabies and preparation method thereof

Technical field

The present invention relates to animal field of medicaments, particularly a kind of compound bee-glue composition that is specifically designed to treatment porcine pseudorabies and preparation method thereof.

Background technology

Porcine pseudorabies is a kind of acute infectious disease being caused by porcine pseudorabies virus, and the pig at various ages all can infect, and newborn piglet shows as nervous symptoms, also can encroach on digestive system; Adult Pig is often inapparent infection, and in-pig can cause miscarriage, stillborn fetus and Respiratory symptoms after infecting; Primary disease case fatality rate can reach 30%-60%.Primary disease all can occur throughout the year, is one of principal disease of harm pig industry.

This disease almost spreads all over all countries of raising pigs of the world, is widely distributed.At present, treat this disease the most frequently used be Chinese medicine, antiviral Western medicine and antimicrobial drug, Chinese medicine is because its prescription is unreasonable or simple pulverizing just, particle diameter is excessive, drug release is slower, causes its bioavailability lower, clinical effectiveness is not fine; Antimicrobial drug, owing to having drug residue and easily producing drug resistance, uses and is subject to strict restriction; And various antiviral agents ban use of as the Ministry of Agriculture such as ribavirin, amantadine.

Therefore research and develop a kind of drug residue free for the treatment of porcine pseudorabies, the specific medicament producing that has no drug resistance is one of this field scientific research technical staff new problem anxious to be resolved.

Summary of the invention

The object of the invention is to overcome above-mentioned weak point, provide that a kind of reasonable recipe, preparation are simple, micronizing, bioavailability are high, successful, have no drug resistance and the compound bee-glue composition of effective treatment porcine pseudorabies of drug residue and preparation method thereof.

Implementation of the present invention is as follows for achieving the above object: a kind of compound bee-glue composition for the treatment of porcine pseudorabies, by following component by weight mixed preparing form: propolis 15-35 part, pig are with interferon 10-20 part, Radix Astragali 15-45 part, Radix Isatidis 15-35 part, Rhizoma Gastrodiae 15-45 part, Herba Euphorbiae Humifusae 10-35 part, Herba Houttuyniae 10-35 part, Herba Scutellariae Barbatae 15-35 part, Fructus Forsythiae 15-35 part, Venenum Bufonis 15-35 part.

On the basis of such scheme, described various component optimum ratio amounts are: 25 parts of propolis, 15 parts of interferon, 30 parts of the Radixs Astragali, 25 parts of Radix Isatidis, 35 parts, Rhizoma Gastrodiae, 15 parts of Herba Euphorbiae Humifusaes, 25 parts of Herba Houttuyniae, 25 parts of Herba Scutellariae Barbataes, 25 parts of Fructus Forsythiaes, 25 parts of Venenum Bufoniss for pig.

Treat a preparation method for the compound bee-glue composition of porcine pseudorabies, it is characterized in that carrying out as follows:

(1) the various compositions (except interferon) in prescription are crossed to 700 mesh sieves after micronizing respectively;

(2) take by weight propolis 15-35 part, pig interferon 10-20 part, Radix Astragali 15-45 part, Radix Isatidis 15-35 part, Rhizoma Gastrodiae 15-45 part, mix 5-10 minute to even;

(3) take by weight Herba Euphorbiae Humifusae 10-35 part, Herba Houttuyniae 10-35 part, Herba Scutellariae Barbatae 15-35 part, Fructus Forsythiae 15-35 part, Venenum Bufonis 15-35 part, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.

The medicinal property of each component is as follows:

Propolis: bitter, acrid, cold, return spleen, stomach warp, the function that there is anti-inflammation, antalgesic-antipruritic, promotion tissue regeneration, improve immunity, antiallergic is oxidized, stops blooding, protects gastrointestinal mucosa.

Interferon: be a kind of broad-spectrum disease resistance toxic agent, RNA and DNA viruses are had to inhibition or killing action; Can inducing apoptosis of tumour cell, thus killing off tumor cells; Interferon all has immunological enhancement to humoral immunization, cellular immunization, macrophage and NK cell.

The Radix Astragali: sweet, tepor, return spleen, lung meridian, there is the function of tonifying Qi and lifting yang, strengthening superficial resistance to stop perspiration, inducing diuresis to remove edema, expelling pus and toxin by strengthening QI, expelling pus and promoting granulation; Curing mainly asthenia of pulmonosplenic qi, sinking of QI of middle-JIAO, exterior deficiency spontaneous perspiration, deficiency of vital energy edema, carbuncle sore difficultly bursts, bursts for a long time and do not hold back etc.

Radix Isatidis: bitter, cold, GUIXIN, stomach warp, have the function of heat-clearing and toxic substances removing, removing heat from blood sore-throat relieving; Cure mainly anemopyretic cold, laryngopharynx swelling and pain, aphtha of the mouth and tongue, skin ulcer general edema with yellowish skin poison etc.

Herba Euphorbiae Humifusae: pungent, flat, return liver, large intestine channel, there is the function of heat-clearing and toxic substances removing, cooling blood for hemostasis; Cure mainly dysentery, intestinal Huang, have blood in stool, hematuria, hemoptysis, traumatic injury, carbuncle malignant boil etc.

Herba Houttuyniae: pungent, be slightly cold, return lung meridian, there is the functions such as heat-clearing and toxic substances removing, detumescence and apocenosis, inducing diuresis for treating stranguria syndrome, cure mainly dysentery, intestinal Huang, lung abscess, acute mastitis, stranguria with turbid discharge etc.

Herba Scutellariae Barbatae: pungent, bitter, cold, return lung, liver, kidney channel, there is the function of heat-clearing and toxic substances removing, blood stasis dispersing and deswelling, diuresis; Cure mainly diarrhea due to damp-heat, furuncle swelling toxin, laryngopharynx swelling and pain, edema, jaundice etc.

Fructus Forsythiae: bitter, cold, return lung, the heart, small intestine meridian, there is the function of heat-clearing and toxic substances removing, dispersing swelling and dissipating binds; Cure mainly epidemic febrile disease heating, skin ulcer general edema with yellowish skin poison etc.

Venenum Bufonis: pungent, warm, GUIXIN warp, the function of there is removing toxic substances, pain relieving, having one's ideas straightened out; Cure mainly the yellow furunculosis of furuncle, laryngopharynx swelling and pain etc.

Rhizoma Gastrodiae: sweet, flat, return Liver Channel, there is the function of suppressing the hyperactive liver to relieve the wind syndrome, relieving spasm to stop pain; Cure mainly that convulsion with spasms, facial hemiparalysis, limbs are tetanic, anemofrigid-damp arthralgia etc.

All taste Chinese medicine, according to Chinese medical theory compatible combination, for pathogenic microorganism and the clinical symptoms of porcine pseudorabies, is brought into play the effect for the treatment of both the principal and secondary aspects of a disease above.

The invention has the beneficial effects as follows: reasonable recipe, preparation is simple, and substep mixes more even; Chinese medicine composition is pollution-free, no drug residue, have no drug resistance, and cost is low, draws materials wide, and micronizing, bioavailability are high, curative effect highly significant.The present invention is according to Chinese veterinarian's traditional theory, optimize this nine tastes Chinese medicine, and make them form pure Chinese powder medicine according to optimum ratio, clinical practice proves, treatment porcine pseudorabies is had to specially good effect, and make its product meat reach nuisanceless requirement, meet the export standard of product, effectively guaranteed that people's is healthy.

The specific embodiment

Below in conjunction with preferred embodiment, to according to the specific embodiment provided by the invention, details are as follows:

Embodiment 1

A kind of compound bee-glue composition for the treatment of porcine pseudorabies and preparation method thereof: carry out as follows: (every part by 10g)

(1) the various compositions (except interferon) in prescription are crossed to 700 mesh sieves after micronizing respectively;

(2) take by weight 150 parts of propolis, 100 parts of interferon, 150 parts of the Radixs Astragali, 150 parts of Radix Isatidis, 150 parts, Rhizoma Gastrodiae for pig, mix 5-10 minute to evenly;

(3) take by weight 100 parts of Herba Euphorbiae Humifusaes, 100 parts of Herba Houttuyniae, 150 parts of Herba Scutellariae Barbataes, 150 parts of Fructus Forsythiaes, 150 parts of Venenum Bufoniss, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.

Embodiment 2

A kind of compound bee-glue composition for the treatment of porcine pseudorabies and preparation method thereof: carry out as follows: (every part by 10g)

(1) the various compositions (except interferon) in prescription are crossed to 700 mesh sieves after micronizing respectively;

(2) take by weight 250 parts of propolis, 150 parts of interferon, 300 parts of the Radixs Astragali, 250 parts of Radix Isatidis, 300 parts, Rhizoma Gastrodiae for pig, mix 5-10 minute to evenly;

(3) take by weight 250 parts of Herba Euphorbiae Humifusaes, 150 parts of Herba Houttuyniae, 250 parts of Herba Scutellariae Barbataes, 250 parts of Fructus Forsythiaes, 250 parts of Venenum Bufoniss, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.

Embodiment 3

A kind of compound bee-glue composition for the treatment of porcine pseudorabies and preparation method thereof: carry out as follows: (every part by 10g)

(1) the various compositions (except interferon) in prescription are crossed to 700 mesh sieves after micronizing respectively;

(2) take by weight 350 parts of propolis, 00 part of interferon alpha-2,450 parts of the Radixs Astragali, 350 parts of Radix Isatidis, 450 parts, Rhizoma Gastrodiae for pig, mix 5-10 minute to evenly;

(3) take by weight 350 parts of Herba Euphorbiae Humifusaes, 350 parts of Herba Houttuyniae, 350 parts of Herba Scutellariae Barbataes, 350 parts of Fructus Forsythiaes, 350 parts of Venenum Bufoniss, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.

Clinical trial:

By the ill pig of product feeding of the present invention etc., a day dose is: by the every 100g of the present invention, spice 190kg feeds, and the 340kg that drinks water, every day 2-3 time, is used in conjunction 3-5 day; After oral, reach the object for the treatment of disease by gastrointestinal absorption.

Table is the field applicable cases contrast of the present invention and other medicines treatment porcine pseudorabies:

Numbering	Group	Case fatality rate %	Cure rate %	When end, there is symptom rate %
					Ⅰ	Blank group	32.9	48.2	18.9
Ⅱ	The pseudorabies health group of faling apart	11.3	78.8	9.9
					Ⅲ	Present composition group	5.8	88.6	5.6

This clinical effectiveness statistical analysis, the loose group of present composition treatment group and pseudorabies health extremely significantly (P < 0.01) of difference compared with aspect cure rate.

The above-mentioned detailed description that compound bee-glue composition to this treatment porcine pseudorabies and preparation method thereof carries out with reference to embodiment; illustrative rather than determinate; can list several embodiment according to institute's limited range; therefore in the variation and the modification that do not depart under general plotting of the present invention, within should belonging to protection scope of the present invention.

Claims (3)

1. treat a compound bee-glue composition for porcine pseudorabies, it is characterized in that by following component by weight mixed preparing form: propolis 15-35 part, pig are with interferon 10-20 part, Radix Astragali 15-45 part, Radix Isatidis 15-35 part, Rhizoma Gastrodiae 15-45 part, Herba Euphorbiae Humifusae 10-35 part, Herba Houttuyniae 10-35 part, Herba Scutellariae Barbatae 15-35 part, Fructus Forsythiae 15-35 part, Venenum Bufonis 15-35 part.

2. a kind of compound bee-glue composition for the treatment of porcine pseudorabies according to claim 1, it is characterized in that by following component by weight mixed preparing form: 25 parts of propolis, 15 parts of interferon, 30 parts of the Radixs Astragali, 25 parts of Radix Isatidis, 35 parts, Rhizoma Gastrodiae, 15 parts of Herba Euphorbiae Humifusaes, 25 parts of Herba Houttuyniae, 25 parts of Herba Scutellariae Barbataes, 25 parts of Fructus Forsythiaes, 25 parts of Venenum Bufoniss for pig.

3. a preparation method for the compound bee-glue composition for the treatment of porcine pseudorabies according to claim 1, is characterized in that carrying out as follows:

(1) the various compositions except interferon in prescription are crossed to 700 mesh sieves after micronizing respectively;

(2) take by weight propolis 15-35 part, pig interferon 10-20 part, Radix Astragali 15-45 part, Radix Isatidis 15-35 part, Rhizoma Gastrodiae 15-45 part, mix 5-10 minute to even;

(3) take by weight Herba Euphorbiae Humifusae 10-35 part, Herba Houttuyniae 10-35 part, Herba Scutellariae Barbatae 15-35 part, Fructus Forsythiae 15-35 part, Venenum Bufonis 15-35 part, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.