CN102397529B - Compound propolis composition for treating chicken reticuloendotheliosis and preparation method thereof - Google Patents

Abstract

The invention discloses a compound propolis composition for treating chicken reticuloendotheliosis and a preparation method thereof, relating to the technical field of animal medicaments. The preparation method of the composition comprises the following steps of: (1) performing ultrafine smashing on various components (except interferon) in a formula respectively, and sieving with a 700-mesh sieve; (2) weighing 15-35 parts by weight of propolis, 5-20 parts by weight of interferon for chicken, 10-35 parts by weight of barbary wolfberry fruit and 15-30 parts by weight of Chinese angelica, and mixing for 5-10 minutes to uniform state; (3) weighing 10-30 parts by weight of prepared rehmannia, 10-30 parts by weight of Chinese thorowax root, 15-45 parts by weight of indigowoad leaf and 10-35 parts by weight of red paeony root, and mixing for 5-10 minutes to a uniform state; and (4) combining the compositions obtained in the steps (2) and (3), and continually mixing for 10-15 minutes to uniform state to obtain the compound propolis composition. The preparation method has the beneficial effects of reasonable formula and easiness for preparing; the compound propolis composition has the advantages of no toxic or side effect, environmental friendliness, no medicament residue, no medicament tolerance, ultrafine smashing, high bioavailability and very remarkable curative effect; and as proved by clinical application, the compound propolis composition has a special treatment effect on chicken reticuloendotheliosis.

Description

A kind of compound bee-glue composition for the treatment of chicken reticuloendotheliosis disease and preparation method thereof

Technical field

The present invention relates to the animal field of medicaments, particularly a kind of compound bee-glue composition for the treatment of chicken reticuloendotheliosis disease and preparation method thereof.

Background technology

Chicken reticuloendotheliosis disease is the one group of syndrome that is caused by chicken reticuloendotheliosis disease virus groups, comprises the chronic tumor that acute skein cell tumor formation, short and small syndrome and lymphoid tissue and its hetero-organization form.This disease is inhibitive ability of immunity and egg transmissibility infectious disease, and the chicken of the various length of times and kind all can infect, and mortality rate, generally lower than 20%, can affect growth and the egg laying performance of poultry.This disease all can occur throughout the year, is one of principal disease of harm poultry husbandry.

The pathogen of primary disease is chicken reticuloendotheliosis disease virus groups, and virus resistance to external world is very strong.This disease almost spreads all over all poultry countries of the world, is widely distributed.At present, prevent and treat this disease the most frequently used be anti virus herb and Western medicine, Chinese medicine is because its prescription is unreasonable or simple pulverizing the just, particle diameter is excessive, drug release is slower, causes its bioavailability lower, clinical effectiveness is not fine; And various antiviral drugs such as the Ministry of Agriculture such as ribavirin, amantadine ban use of.

Therefore researching and developing a kind of drug residue free of chicken reticuloendotheliosis disease, the generation that has no drug resistance, the significant specific medicament of clinical effectiveness for the treatment of is one of new problem of needing to be resolved hurrily of this field scientific research technical staff.

Summary of the invention

The object of the invention is to overcome above-mentioned weak point, provide that a kind of reasonable recipe, preparation are simple, micronizing, bioavailability are high, successful, have no drug resistance and the compound bee-glue composition of the effective treatment chicken reticuloendotheliosis disease of drug residue and preparation method thereof.

For achieving the above object, implementation of the present invention is as follows: a kind of compound bee-glue composition for the treatment of chicken reticuloendotheliosis disease, by following component by weight mixed preparing form: propolis 15-35 part, chicken are with interferon 5-20 part, Fructus Lycii 10-35 part, Radix Angelicae Sinensis 15-30 part, Radix Rehmanniae Preparata 10-30 part, Radix Bupleuri 10-30 part, Folium Isatidis 15-45 part, Radix Paeoniae Rubra 10-35 part.

Described various component optimum ratio amount is: 30 parts of propolis, 10 parts of interferon of chicken, 25 parts of Fructus Lyciis, 20 parts of Radix Angelicae Sinensis, 20 parts of Radix Rehmanniae Preparata, 20 parts of Radix Bupleuri, 30 parts of Folium Isatidiss, 25 parts of Radix Paeoniae Rubra.

A kind of preparation method for the treatment of the compound bee-glue composition of chicken reticuloendotheliosis disease, carry out as follows:

(1) the various compositions (except interferon) in prescription are crossed 700 mesh sieves after micronizing respectively;

(2) take by weight propolis 15-35 part, chicken with interferon 5-20 part, Fructus Lycii 10-35 part, Radix Angelicae Sinensis 15-30 part, mix 5-10 minute to even;

(3) take by weight Radix Rehmanniae Preparata 10-30 part, Radix Bupleuri 10-30 part, Folium Isatidis 15-45 part, Radix Paeoniae Rubra 10-35 part, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.

The medicinal property of each component is as follows:

Propolis: bitter, acrid, cold, return spleen, stomach warp, have the function of anti-inflammation, antalgesic-antipruritic, promotion tissue regeneration, raising immunity, antiallergic oxidation, hemostasis, protection gastrointestinal mucosa.

Interferon: be a kind of broad-spectrum disease resistance toxic agent, RNA and DNA viruses are had inhibition or killing action; Can inducing apoptosis of tumour cell, thus killing off tumor cells; Interferon all has immunological enhancement to humoral immunization, cellular immunization, macrophage and NK cell.

Fructus Lycii: sweet, flat, return liver, kidney channel, have the function of liver and kidney tonifying, replenishing vital essence to improve eyesight; Cure mainly the hepatic and renal YIN deficiency, waist unable etc.

Radix Angelicae Sinensis: sweet, hot, warm, return liver, the heart, spleen channel, have the function of blood-supplementing blood-nourishing, promoting blood circulation and stopping pain, moistening dryness for relaxing bowels; Cure mainly blood deficiency impairment caused by overstrain, blood stasis pain, traumatic injury, carbuncle skin infection, dryness of the intestine constipation etc.

Radix Rehmanniae Preparata: sweet, tepor, return liver, kidney channel, have the function that nourishing YIN and supplementing blood, beneficial essence are filled out marrow; Cure mainly that the hepatic and renal YIN deficiency, blood deficiency damage of essence, waist hip flaccidity are soft, dyspnea due to deficiency chronic cough, deficiency-heat night sweat etc.

Radix Bupleuri: hot, bitter, be slightly cold, return liver, gallbladder, lung meridian, have the function of delivering with inner, elevate a turnable ladder yang-energy, dispersing the stagnated live-QI to relieve the stagnation of QI; Cure mainly cold, fever, alternate attack of chill and fever, insufficiency of the spleen chronic diarrhea etc.

Folium Isatidis: bitter, cold, GUIXIN, stomach warp, have the function of heat-clearing and toxic substances removing, blood cooling and ecchymoses removing; Cure mainly calentura and send out speckle, laryngopharynx swelling and pain, hematodiarrhoea, jaundice, carbuncle, erysipelas etc.

Radix Paeoniae Rubra: bitter, be slightly cold, return Liver Channel, have the function of clearing away heat and cooling blood, eliminating stasis to stop pain; Cure mainly maculae caused by violent heat pathogen, the hot hematochezia of intestinal, conjunctival congestion and swelling pain, too fat to move skin infection, traumatic injury etc.

Above all flavor Chinese medicine, according to the Chinese medical theory compatible combination,, for pathogenic microorganism and clinical symptoms and the pathological change of chicken reticuloendotheliosis disease, is brought into play the effect for the treatment of both the principal and secondary aspects of a disease.

The invention has the beneficial effects as follows: reasonable recipe, preparation is simple, and substep mixes more even; Chinese medicine composition is pollution-free, no drug residue, have no drug resistance, and cost is low, draws materials wide, and micronizing, bioavailability are high, can also can drink water by spice, and the curative effect highly significant.The present invention is according to Chinese veterinarian's traditional theory, optimize this seven flavors Chinese medicine, and make them according to optimum ratio, form pure Chinese powder medicine, clinical practice proves, there is specially good effect in chicken reticuloendotheliosis disease to treatment, and make its product meat reach nuisanceless requirement, meet the export standard of product, guaranteed that effectively people's is healthy.

The specific embodiment

Below in conjunction with preferred embodiment, to details are as follows according to the specific embodiment provided by the invention:

Embodiment 1

A kind of compound bee-glue composition for the treatment of chicken reticuloendotheliosis disease and preparation method thereof: carry out as follows: (every part by 10g)

(1) the various compositions (except interferon) in prescription are crossed 700 mesh sieves after micronizing respectively;

(2) take by weight 150 parts of propolis, chicken with 50 parts of interferon, 100 parts of Fructus Lyciis, 150 parts of Radix Angelicae Sinensis, mix 5-10 minute to even;

(3) take by weight 100 parts of Radix Rehmanniae Preparata, 100 parts of Radix Bupleuri, 150 parts of Folium Isatidiss, 100 parts of Radix Paeoniae Rubra, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.

Embodiment 2

A kind of compound bee-glue composition for the treatment of chicken reticuloendotheliosis disease and preparation method thereof: carry out as follows: (every part by 10g)

(1) the various compositions (except interferon) in prescription are crossed 700 mesh sieves after micronizing respectively;

(2) take by weight 250 parts of propolis, chicken with 100 parts of interferon, 250 parts of Fructus Lyciis, 200 parts of Radix Angelicae Sinensis, mix 5-10 minute to even;

(3) take by weight 200 parts of Radix Rehmanniae Preparata, 200 parts of Radix Bupleuri, 300 parts of Folium Isatidiss, 250 parts of Radix Paeoniae Rubra, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.

Embodiment 3

A kind of compound bee-glue composition for the treatment of chicken reticuloendotheliosis disease and preparation method thereof: carry out as follows: (every part by 10g)

(1) the various compositions (except interferon) in prescription are crossed 700 mesh sieves after micronizing respectively;

(2) take by weight 350 parts of propolis, chicken with 00 part of interferon alpha-2,350 parts of Fructus Lyciis, 300 parts of Radix Angelicae Sinensis, mix 5-10 minute to even;

(3) take by weight 300 parts of Radix Rehmanniae Preparata, 300 parts of Radix Bupleuri, 450 parts of Folium Isatidiss, 350 parts of Radix Paeoniae Rubra, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.

Clinical trial:

With the ill poultry of product feeding of the present invention etc., a day dose is: by the every 100g of the present invention, spice 120kg feeds, and drinking-water 200kg, every day 2-3 time, be used in conjunction 3-5 day; Reach the purpose for the treatment of disease after oral by gastrointestinal absorption.

Table is the field applicable cases contrast of the present invention and other medicines treatment chicken reticuloendotheliosis disease:

Numbering	Group	Mortality rate %	Cure rate %	Symptom rate % is arranged during end
					I	The blank group	10.9	43.9	45.2
Ⅱ	The chicken reticuloendotheliosis disease group group of faling apart	7.8	78.3	13.9
					III	Chinese medicine composition group of the present invention	4.5	86.6	8.9

This clinical effectiveness statistical analysis, present composition treatment group fall apart to organize with chicken reticuloendotheliosis disease and are comparing difference extremely significantly (P＜0.01) aspect cure rate.

Above-mentioned detailed description of compound bee-glue composition of this treatment chicken reticuloendotheliosis disease and preparation method thereof being carried out with reference to embodiment; illustrative rather than determinate; can list several embodiment according to institute's limited range; therefore in the variation and the modification that do not break away under general plotting of the present invention, within should belonging to protection scope of the present invention.

Claims (3)

1. compound bee-glue composition for the treatment of chicken reticuloendotheliosis disease, it is characterized in that by following component by weight mixed preparing form: propolis 15-35 part, chicken are with interferon 5-20 part, Fructus Lycii 10-35 part, Radix Angelicae Sinensis 15-30 part, Radix Rehmanniae Preparata 10-30 part, Radix Bupleuri 10-30 part, Folium Isatidis 15-45 part, Radix Paeoniae Rubra 10-35 part.

2. compound bee-glue composition for the treatment of chicken reticuloendotheliosis disease according to claim 1, is characterized in that described various component optimum ratio amount is: 30 parts of propolis, 10 parts of interferon of chicken, 25 parts of Fructus Lyciis, 20 parts of Radix Angelicae Sinensis, 20 parts of Radix Rehmanniae Preparata, 20 parts of Radix Bupleuri, 30 parts of Folium Isatidiss, 25 parts of Radix Paeoniae Rubra.

3. the preparation method of the compound bee-glue composition of a treatment according to claim 1 chicken reticuloendotheliosis disease is characterized in that carrying out as follows:

(1) the various compositions (except interferon) in prescription are crossed 700 mesh sieves after micronizing respectively;

(2) take by weight and get propolis 15-35 part, chicken with interferon 5-20 part, Fructus Lycii 10-35 part, Radix Angelicae Sinensis 15-30 part, mix 5-10 minute to even;

(3) take by weight Radix Rehmanniae Preparata 10-30 part, Radix Bupleuri 10-30 part, Folium Isatidis 15-45 part, Radix Paeoniae Rubra 10-35 part, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.