CN102370970B - Traditional Chinese medicine compound composition for treating blue ear disease of sows and preparation method thereof - Google Patents

Abstract

The invention provides a traditional Chinese medicine compound composition for treating the blue ear disease of sows and a preparation method thereof, which relate to the field of veterinary medicines. The invention aims at providing the traditional Chinese medicine compound composition for treating the blue ear disease of the sows, which has a reasonable prescription and is simple to prepare, and the preparation method thereof. The concrete components and the preparation method are as follows: (1) various components (except for an interferon) in the prescription are sieved by a sieve with 500 meshes after the components are respectively pulverized in a superfine way; (2) 15 to 25 parts of bee glue, 5 to 15 parts of interferon for pigs, 10 to 25 parts of fructus amomi and 15 to 30 parts of stir-fried mugwort leaf are weighed by weight and are mixed for 5 to 10 minutes into a uniform state; (3) 10 to 30 parts of baikal skullcap root, 10 to 35 parts of honeysuckle, 10 to 25 parts of rhizoma atractylodis macrocephalae and 10 to 20 parts of red peony root are weighed by weight and are mixed for 5 to 10 minutes into a uniform state; and (4) the compositions prepared in the steps (2) and (3) are combined and are continuously mixed for 10 to 15 minutes into a uniform state so as to form the traditional Chinese medicine compound composition. The invention has the beneficial effects that the composition has no toxic or side effect, no pollution, no medicine residue, no medicine tolerance, superfine pulverization and high bioavailability; and the clinic proves that the composition has a special effect for treating the blue ear disease of the sows.

Description

A kind of herbal mixture composition and method of making the same for the treatment of sow reproductive and respiratory syndrome

Technical field

Field of veterinary of the present invention, particularly a kind of herbal mixture composition and method of making the same for the treatment of sow reproductive and respiratory syndrome.

Background technology

Pig blue-ear disease is a kind of height contagious disease being caused by PRRS virus, has hyperinfection and lethal.The pig of various kinds, all ages and classes and purposes all can infect, but with in-pig and 1 monthly age with the susceptible of interior piglet.It is characterized in that: morbidity sow main manifestations for spirit is depressed, poor appetite or useless absolutely, heating, sow is miscarried, premature labor, stillborn fetus, mummy tire, weak son etc., sow abortion ratio can reach 50%～70%; Newborn piglet main manifestations dyspnea, the symptoms such as movement disorder and paresis, in 1 week puerperal, mortality rate obviously increases (40%～80%).Primary disease all can occur throughout the year, is one of principal disease of harm pig industry.

The pathogen of primary disease is PRRS virus, and this disease almost spreads all over all countries of raising pigs in the world, is widely distributed.At present, treat this disease the most frequently used be Chinese medicine and antiviral Western medicine, Chinese medicine is because its prescription is unreasonable or simple pulverizing just, particle diameter is excessive, drug release is slower, causes its bioavailability lower, clinical effectiveness is not fine; And various antiviral agents ban use of as Ministry of Agriculture such as ribavirin, amantadines.

Therefore research and develop a kind of drug residue free for the treatment of sow reproductive and respiratory syndrome, the specific medicament producing that has no drug resistance is one of this field scientific research technical staff new problem anxious to be resolved.

Summary of the invention

The object of the invention is to overcome above-mentioned weak point, provide that a kind of reasonable recipe, preparation are simple, micronizing, bioavailability are high, successful, have no drug resistance and the herbal mixture composition and method of making the same of effective treatment sow reproductive and respiratory syndrome of drug residue.

Implementation of the present invention is as follows for achieving the above object: a kind of herbal mixture compositions for the treatment of sow reproductive and respiratory syndrome, by following component by weight mixed preparing form: propolis 15-25 part, pig are with interferon 5-15 part, Fructus Amomi 10-25 part, Folium Artemisiae Argyi (parched) 15-30 part, Radix Scutellariae 10-30 part, Flos Lonicerae 10-35 part, Rhizoma Atractylodis Macrocephalae 10-25 part, Radix Paeoniae Rubra 10-20 part.

Described various component optimum ratio amount is: 20 parts of propolis, 8 parts of interferon, 15 parts of Fructus Amomis, 25 parts of Folium Artemisiae Argyi (parched), 20 parts of Radix Scutellariaes, 25 parts of Flos Loniceraes, 15 parts of the Rhizoma Atractylodis Macrocephalaes, 15 parts of Radix Paeoniae Rubra for pig.

Treat a preparation method for the herbal mixture compositions of sow reproductive and respiratory syndrome, carry out as follows:

(1) the various compositions (except interferon) in prescription are crossed to 500 mesh sieves after micronizing respectively;

(2) take by weight propolis 15-25 part, pig interferon 5-15 part, Fructus Amomi 10-25 part, Folium Artemisiae Argyi (parched) 15-30 part, mix 5-10 minute to even;

(3) take by weight Radix Scutellariae 10-30 part, Flos Lonicerae 10-35 part, Rhizoma Atractylodis Macrocephalae 10-25 part, Radix Paeoniae Rubra 10-20 part, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.

The medicinal property of each component is as follows:

Propolis: bitter, acrid, cold, return spleen, stomach warp, the function that there is anti-inflammation, antalgesic-antipruritic, promotion tissue regeneration, improve immunity, antiallergic is oxidized, stops blooding, protects gastrointestinal mucosa.

Interferon: be a kind of broad-spectrum disease resistance toxic agent, RNA and DNA viruses are had to inhibition or killing action; Can inducing apoptosis of tumour cell, thus killing off tumor cells; Interferon all has immunological enhancement to humoral immunization, cellular immunization, macrophage and NK cell.

Fructus Amomi: pungent, warm, return spleen, stomach, kidney channel, there is removing dampness appetizing, warming the spleen stopping leak, the antiabortive function of regulating the flow of vital energy; Cure mainly that stagnation of QI in spleen and stomach, dyspepsia do not disappear, tripe is swollen, food is told in regurgitation, cold type of pain, increased borborygmus and diarrhea, frequent fetal movement etc.

Folium Artemisiae Argyi: bitter, temperature, pungent, return liver,spleen,kidney warp, there is the function of dispersing cold for relieving pain, warming the meridian for stopping bleeding; Cure mainly anemofrigid-damp arthralgia, tripe abdomen cold type of pain, infertility, frequent fetal movement etc.

Flos Lonicerae: sweet, cold, return lung, stomach, heart channel, there is the function of heat-clearing and toxic substances removing, dispelling wind and heat pathogens; Cure mainly epidemic febrile disease heating, anemopyretic cold, cough due to lung-heat, laryngopharynx swelling and pain, toxic-heat and blood stasis, breast swell and pain, carbuncle sore tumefacting virus etc.

Radix Scutellariae: bitter, cold, return lung, gallbladder, spleen, large intestine, small intestine meridian, there is heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive function. cure mainly that cough due to lung-heat, gastrointestinal are damp and hot, dysentery, jaundice, high heat are greedyly drunk, have blood in stool, epistaxis, conjunctival congestion and swelling pain, carbuncle sore tumefacting virus, frequent fetal movement etc.

The Rhizoma Atractylodis Macrocephalae: bitter, sweet, warm, return spleen, stomach warp, there is the function of invigorating the spleen and replenishing QI, dampness diuretic, antiabortive, hidroschesis; Cure mainly diarrhea due to hypofunction of the spleen, edema, frequent fetal movement, sweating due to debility etc.

Radix Paeoniae Rubra: bitter, be slightly cold, return Liver Channel, there is the function of clearing away heat and cooling blood, eliminating stasis to stop pain; Cure mainly maculae caused by violent heat pathogen, the hot hematochezia of intestinal, conjunctival congestion and swelling pain, carbuncle skin infection etc.

All taste Chinese medicine, according to Chinese medical theory compatible combination, for pathogenic microorganism, clinical symptoms and the pathological change of pig blue-ear disease, is brought into play the effect for the treatment of both the principal and secondary aspects of a disease above.

The invention has the beneficial effects as follows: reasonable recipe, preparation is simple, and substep mixes more even; Chinese medicine composition is pollution-free, no drug residue, have no drug resistance, and cost is low, draws materials wide, and micronizing, bioavailability are high, curative effect highly significant.The present invention is according to Chinese veterinarian's traditional theory, optimize this seven tastes Chinese medicine, and make them according to optimum ratio, form pure Chinese powder medicine, clinical practice proves, treatment sow reproductive and respiratory syndrome is had to specially good effect, and make its product meat reach nuisanceless requirement, meet the export standard of product, effectively guaranteed that people's is healthy.

The specific embodiment

Below in conjunction with preferred embodiment, to according to the specific embodiment provided by the invention, details are as follows:

Embodiment 1

A kind of herbal mixture composition and method of making the same for the treatment of sow reproductive and respiratory syndrome: carry out as follows: (every part by 10g)

(1) the various compositions (except interferon) in prescription are crossed to 500 mesh sieves after micronizing respectively;

(2) take by weight 150 parts of propolis, 50 parts of interferon, 100 parts of Fructus Amomis, 150 parts of Folium Artemisiae Argyi (parched) for pig, mix 5-10 minute to evenly;

(3) take by weight 100 parts of Radix Scutellariaes, 100 parts of Flos Loniceraes, 100 parts of the Rhizoma Atractylodis Macrocephalaes, 100 parts of Radix Paeoniae Rubra, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.

Embodiment 2

A kind of pure Chinese medicine composition for the treatment of sow reproductive and respiratory syndrome and preparation method thereof: carry out as follows: (every part by 10g)

(1) the various compositions (except interferon) in prescription are crossed to 500 mesh sieves after micronizing respectively;

(2) take by weight 200 parts of propolis, 100 parts of interferon, 150 parts of Fructus Amomis, 200 parts of Folium Artemisiae Argyi (parched) for pig, mix 5-10 minute to evenly;

(3) take by weight 200 parts of Radix Scutellariaes, 150 parts of Flos Loniceraes, 150 parts of the Rhizoma Atractylodis Macrocephalaes, 150 parts of Radix Paeoniae Rubra, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.

Embodiment 3

A kind of pure Chinese medicine composition for the treatment of sow reproductive and respiratory syndrome and preparation method thereof: carry out as follows: (every part by 10g)

(1) the various compositions (except interferon) in prescription are crossed to 500 mesh sieves after micronizing respectively;

(2) take by weight 250 parts of propolis, 150 parts of interferon, 250 parts of Fructus Amomis, 300 parts of Folium Artemisiae Argyi (parched) for pig, mix 5-10 minute to evenly;

(3) take by weight 300 parts of Radix Scutellariaes, 350 parts of Flos Loniceraes, 250 parts of the Rhizoma Atractylodis Macrocephalaes, 200 parts of Radix Paeoniae Rubra, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.

Clinical trial:

By the ill sow of product feeding of the present invention etc., a day dose is: by the every 100g of the present invention, spice 150kg feeds, and the 300kg that drinks water, every day 2-3 time, is used in conjunction 3-5 day; After oral, by gastrointestinal absorption, reach the object for the treatment of disease.

Table is the field applicable cases contrast of the present invention and other medicines treatment sow reproductive and respiratory syndrome:

Numbering	Group	Abortion ratio %	Cure rate %	During end, there is symptom rate %
					I	Blank group	53.5	10.1	36.4
II	The loose group of the blue ear health of pig	30.2	56.9	12.9
					III	Chinese medicine composition of the present invention	16.2	75.4	8.4

This clinical effectiveness statistical analysis, the loose group of the blue ear health of present composition treatment group and pig extremely significantly (P < 0.01) of difference compared with aspect cure rate.

The above-mentioned detailed description that pure Chinese medicine composition to this treatment sow reproductive and respiratory syndrome and preparation method thereof carries out with reference to embodiment; illustrative rather than determinate; can list several embodiment according to institute's limited range; therefore in the variation and the modification that do not depart under general plotting of the present invention, within should belonging to protection scope of the present invention.

Claims (3)

1. treat a herbal mixture compositions for sow reproductive and respiratory syndrome, it is characterized in that by following component by weight mixed preparing form: propolis 15-25 part, pig are with interferon 5-15 part, Fructus Amomi 10-25 part, Folium Artemisiae Argyi (parched) 15-30 part, Radix Scutellariae 10-30 part, Flos Lonicerae 10-35 part, Rhizoma Atractylodis Macrocephalae 10-25 part, Radix Paeoniae Rubra 10-20 part.

2. a kind of herbal mixture compositions for the treatment of sow reproductive and respiratory syndrome according to claim 1, is characterized in that described various component optimum ratio amount is: 20 parts of propolis, 8 parts of interferon, 15 parts of Fructus Amomis, 25 parts of Folium Artemisiae Argyi (parched), 20 parts of Radix Scutellariaes, 25 parts of Flos Loniceraes, 15 parts of the Rhizoma Atractylodis Macrocephalaes, 15 parts of Radix Paeoniae Rubra for pig.

3. a preparation method for the herbal mixture compositions for the treatment of sow reproductive and respiratory syndrome according to claim 1, is characterized in that carrying out as follows:

(1) the various compositions except interferon in prescription are crossed to 500 mesh sieves after micronizing respectively;

(2) take by weight propolis 15-25 part, pig interferon 5-15 part, Fructus Amomi 10-25 part, Folium Artemisiae Argyi (parched) 15-30 part, mix 5-10 minute to even;

(3) take by weight Radix Scutellariae 10-30 part, Flos Lonicerae 10-35 part, Rhizoma Atractylodis Macrocephalae 10-25 part, Radix Paeoniae Rubra 10-20 part, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.