CN102370970A - Traditional Chinese medicine compound composition for treating blue ear disease of sows and preparation method thereof - Google Patents

Abstract

The invention provides a traditional Chinese medicine compound composition for treating the blue ear disease of sows and a preparation method thereof, which relate to the field of veterinary medicines. The invention aims at providing the traditional Chinese medicine compound composition for treating the blue ear disease of the sows, which has a reasonable prescription and is simple to prepare, and the preparation method thereof. The concrete components and the preparation method are as follows: (1) various components (except for an interferon) in the prescription are sieved by a sieve with 500 meshes after the components are respectively pulverized in a superfine way; (2) 15 to 25 parts of bee glue, 5 to 15 parts of interferon for pigs, 10 to 25 parts of fructus amomi and 15 to 30 parts of stir-fried mugwort leaf are weighed by weight and are mixed for 5 to 10 minutes into a uniform state; (3) 10 to 30 parts of baikal skullcap root, 10 to 35 parts of honeysuckle, 10 to 25 parts of rhizoma atractylodis macrocephalae and 10 to 20 parts of red peony root are weighed by weight and are mixed for 5 to 10 minutes into a uniform state; and (4) the compositions prepared in the steps (2) and (3) are combined and are continuously mixed for 10 to 15 minutes into a uniform state so as to form the traditional Chinese medicine compound composition. The invention has the beneficial effects that the composition has no toxic or side effect, no pollution, no medicine residue, no medicine tolerance, superfine pulverization and high bioavailability; and the clinic proves that the composition has a special effect for treating the blue ear disease of the sows.

Description

A kind of herbal mixture composition and method of making the same of treating the sow reproductive and respiratory syndrome

Technical field

Field of veterinary of the present invention, particularly a kind of herbal mixture composition and method of making the same of treating the sow reproductive and respiratory syndrome.

Background technology

Pig blue-ear disease is a kind of height contagious disease that is caused by PRRS virus, has hyperinfection property and lethal.The pig of various kinds, all ages and classes and purposes all can infect, but with in-pig and 1 monthly age with the susceptible of interior piglet.It is characterized in that: the morbidity sow shows as mainly that depressed, the appetite of spirit reduces or useless exhausted, heating, and sow is miscarried, premature labor, stillborn fetus, mummy tire, weak son etc., and the sow abortion ratio can reach 50%～70%; Newborn piglet mainly shows symptoms such as dyspnea, movement disorder and paresis, and mortality rate obviously increases (40%～80%) in 1 week of puerperal.Primary disease all can take place throughout the year, is one of principal disease of harm pig industry.

The pathogen of primary disease is a PRRS virus, and this disease almost spreads all over all countries of raising pigs of the world, distributes very extensively.At present, treat this disease the most frequently used be Chinese medicine and antiviral Western medicine, Chinese medicine is because its prescription is unreasonable or just simple the pulverizing, and particle diameter is excessive, and drug release is slower, causes its bioavailability lower, clinical effectiveness is not fine; And the various antiviral agents such as the Ministry of Agriculture such as ribavirin, amantadine ban use of.

Therefore researching and developing a kind of specific medicament of treating the drug residue free of sow reproductive and respiratory syndrome, the generation that has no drug resistance is one of this field scientific research technical staff new problem anxious to be solved.

Summary of the invention

The objective of the invention is to overcome above-mentioned weak point, provide that a kind of reasonable recipe, preparation are simple, micronizing, bioavailability are high, effect obviously, have no drug resistance and the herbal mixture composition and method of making the same of effective treatment sow reproductive and respiratory syndrome of drug residue.

Following for realizing the embodiment that above-mentioned purpose the present invention adopted: a kind of herbal mixture compositions of treating the sow reproductive and respiratory syndrome, by following component by weight mixed preparing form: propolis 15-25 part, pig are with interferon 5-15 part, Fructus Amomi 10-25 part, Folium Artemisiae Argyi (parched) 15-30 part, Radix Scutellariae 10-30 part, Flos Lonicerae 10-35 part, Rhizoma Atractylodis Macrocephalae 10-25 part, Radix Paeoniae Rubra 10-20 part.

Said various component optimum ratio amount is: 20 parts of propolis, pig are with 8 parts of interferon, 15 parts of Fructus Amomis, 25 parts of Folium Artemisiae Argyi (parched), 20 parts of Radix Scutellariaes, 25 parts of Flos Loniceraes, 15 parts of the Rhizoma Atractylodis Macrocephalaes, 15 parts of Radix Paeoniae Rubra.

A kind of herbal mixture preparation of compositions method of treating the sow reproductive and respiratory syndrome, carry out as follows:

(1) the various compositions (except the interferon) in the prescription is crossed 500 mesh sieves after the micronizing respectively;

(2) take by weighing propolis 15-25 part, pig by weight with interferon 5-15 part, Fructus Amomi 10-25 part, Folium Artemisiae Argyi (parched) 15-30 part, mix 5-10 minute to even;

(3) take by weighing Radix Scutellariae 10-30 part, Flos Lonicerae 10-35 part, Rhizoma Atractylodis Macrocephalae 10-25 part, Radix Paeoniae Rubra 10-20 part by weight, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.

The medicinal property of each component is following:

Propolis: bitter, hot, cold, return spleen, stomach warp, have the function of anti-inflammation, antalgesic-antipruritic, promotion tissue regeneration, raising immunity, antiallergic oxidation, hemostasis, protection gastrointestinal mucosa.

Interferon: be a kind of broad-spectrum disease resistance toxic agent, RNA and DNA viruses are had inhibition or killing action; Can inducing apoptosis of tumour cell, thus kill tumor cell; Interferon all has immunological enhancement to humoral immunization, cellular immunization, macrophage and NK cell.

Fructus Amomi: hot, warm, return spleen, stomach, kidney channel, have removing dampness appetizing, warming the spleen stopping leak, an antiabortive function of regulating the flow of vital energy; Cure mainly that stagnation of QI in spleen and stomach, dyspepsia do not disappear, tripe expands, food, cold type of pain, increased borborygmus and diarrhea, frequent fetal movement etc. are told in regurgitation.

Folium Artemisiae Argyi: bitter, temperature, hot, return the liver,spleen,kidney warp, have the function of dispersing cold for relieving pain, warming the meridian for stopping bleeding; Cure mainly anemofrigid-damp arthralgia, tripe abdomen cold type of pain, infertility, frequent fetal movement etc.

Flos Lonicerae: sweet, cold, return lung, stomach, heart channel, have the function of heat-clearing and toxic substances removing, dispelling wind and heat pathogens; Cure mainly epidemic febrile disease heating, anemopyretic cold, cough due to lung-heat, laryngopharynx swelling and pain, toxic-heat and blood stasis, breast swell and pain, carbuncle sore tumefacting virus etc.

Radix Scutellariae: bitter, cold; Return lung, gallbladder, spleen, large intestine, small intestine meridian, have heat clearing and damp drying, eliminating fire and detoxication, hemostasis, antiabortive function. cure mainly that cough due to lung-heat, gastrointestinal are damp and hot, dysentery, jaundice, hyperpyrexia are greedyly drunk, have blood in stool, epistaxis, conjunctival congestion and swelling pain, carbuncle sore tumefacting virus, frequent fetal movement etc.

The Rhizoma Atractylodis Macrocephalae: bitter, sweet, warm, return spleen, stomach warp, have invigorating the spleen and replenishing QI, dampness diuretic, antiabortive, antisudorific function; Cure mainly diarrhea due to hypofunction of the spleen, edema, frequent fetal movement, sweating due to debility etc.

Radix Paeoniae Rubra: bitter, be slightly cold, return Liver Channel, have the function of clearing away heat and cooling blood, eliminating stasis to stop pain; Cure mainly maculae caused by violent heat pathogen, the hot hematochezia of intestinal, conjunctival congestion and swelling pain, carbuncle skin infection etc.

More than all flavor Chinese medicine according to the Chinese medical theory compatible combination, to pathogenic microorganism, clinical symptoms and the pathological change of pig blue-ear disease, the effect of performance treating both the principal and secondary aspects of a disease.

The invention has the beneficial effects as follows: reasonable recipe, preparation is simple, and substep mixes more even; Chinese medicine composition is pollution-free, no drug residue, have no drug resistance, and cost is low, and it is wide to draw materials, and micronizing, bioavailability are high, the curative effect highly significant.The present invention is according to Chinese veterinarian's traditional theory; Optimize this seven flavors Chinese medicine, and make them form pure Chinese powder medicine according to optimum ratio, clinical practice proves; Treatment sow reproductive and respiratory syndrome there is specially good effect; And make its product meat reach nuisanceless requirement, satisfy the export standard of product, guaranteed that effectively people's is healthy.

The specific embodiment

Below in conjunction with preferred embodiment, to details are as follows according to the specific embodiment provided by the invention:

Embodiment 1

A kind of herbal mixture composition and method of making the same of treating the sow reproductive and respiratory syndrome: carry out as follows: (every part by 10g)

(1) the various compositions (except the interferon) in the prescription is crossed 500 mesh sieves after the micronizing respectively;

(2) take by weighing 150 parts of propolis, pig by weight with 50 parts of interferon, 100 parts of Fructus Amomis, 150 parts of Folium Artemisiae Argyi (parched), mix 5-10 minute to even;

(3) take by weighing 100 parts of Radix Scutellariaes, 100 parts of Flos Loniceraes, 100 parts of the Rhizoma Atractylodis Macrocephalaes, 100 parts of Radix Paeoniae Rubra by weight, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.

Embodiment 2

A kind of pure Chinese medicine composition of treating the sow reproductive and respiratory syndrome and preparation method thereof: carry out as follows: (every part by 10g)

(1) the various compositions (except the interferon) in the prescription is crossed 500 mesh sieves after the micronizing respectively;

(2) take by weighing 200 parts of propolis, pig by weight with 100 parts of interferon, 150 parts of Fructus Amomis, 200 parts of Folium Artemisiae Argyi (parched), mix 5-10 minute to even;

(3) take by weighing 200 parts of Radix Scutellariaes, 150 parts of Flos Loniceraes, 150 parts of the Rhizoma Atractylodis Macrocephalaes, 150 parts of Radix Paeoniae Rubra by weight, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.

Embodiment 3

A kind of pure Chinese medicine composition of treating the sow reproductive and respiratory syndrome and preparation method thereof: carry out as follows: (every part by 10g)

(1) the various compositions (except the interferon) in the prescription is crossed 500 mesh sieves after the micronizing respectively;

(2) take by weighing 250 parts of propolis, pig by weight with 150 parts of interferon, 250 parts of Fructus Amomis, 300 parts of Folium Artemisiae Argyi (parched), mix 5-10 minute to even;

(3) take by weighing 300 parts of Radix Scutellariaes, 350 parts of Flos Loniceraes, 250 parts of the Rhizoma Atractylodis Macrocephalaes, 200 parts of Radix Paeoniae Rubra by weight, mix 5-10 minute to even;

(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.

Clinical trial:

With the ill sow of product feeding of the present invention etc., a day dose is: by the every 100g of the present invention, spice 150kg feeds, drinking-water 300kg, every day 2-3 time, logotype 3-5 day; Oral back reaches the purpose of treatment disease through gastrointestinal absorption.

Table is the field applicable cases contrast of the present invention and other medicines treatment sow reproductive and respiratory syndrome:

Numbering	Group	Abortion ratio %	Cure rate %	Symptom rate % is arranged during end
					I	The blank group	53.5	10.1	36.4
II	The blue ear health of pig is loose and is organized	30.2	56.9	12.9
					III	Chinese medicine composition of the present invention	16.2	75.4	8.4

This clinical effectiveness is through statistical analysis, and present composition treatment group is loose to organize with the blue ear health of pig and compared difference extremely significantly (P＜0.01) aspect the cure rate.

Above-mentioned detailed description of pure Chinese medicine composition of this treatment sow reproductive and respiratory syndrome and preparation method thereof being carried out with reference to embodiment; Be illustrative rather than determinate; Can enumerate out several embodiment according to institute's limited range; Therefore in the variation and the modification that do not break away under the general plotting of the present invention, should belong within protection scope of the present invention.

Claims (3)

1. herbal mixture compositions of treating the sow reproductive and respiratory syndrome, it is characterized in that by following component by weight mixed preparing form: propolis 15-25 part, pig are with interferon 5-15 part, Fructus Amomi 10-25 part, Folium Artemisiae Argyi (parched) 15-30 part, Radix Scutellariae 10-30 part, Flos Lonicerae 10-35 part, Rhizoma Atractylodis Macrocephalae 10-25 part, Radix Paeoniae Rubra 10-20 part.

2. a kind of herbal mixture compositions of treating the sow reproductive and respiratory syndrome according to claim 1, it is characterized in that said various component optimum ratio amount is: 20 parts of propolis, pig are with 8 parts of interferon, 15 parts of Fructus Amomis, 25 parts of Folium Artemisiae Argyi (parched), 20 parts of Radix Scutellariaes, 25 parts of Flos Loniceraes, 15 parts of the Rhizoma Atractylodis Macrocephalaes, 15 parts of Radix Paeoniae Rubra.

3. the herbal mixture preparation of compositions method of a treatment according to claim 1 and 2 sow reproductive and respiratory syndrome is characterized in that carrying out as follows:

(1) the various compositions (except the interferon) in the prescription is crossed 500 mesh sieves after the micronizing respectively;

(2) take by weighing propolis 15-25 part, pig by weight with interferon 5-15 part, Fructus Amomi 10-25 part, Folium Artemisiae Argyi (parched) 15-30 part, mix 5-10 minute to even;

(3) take by weighing Radix Scutellariae 10-30 part, Flos Lonicerae 10-35 part, Rhizoma Atractylodis Macrocephalae 10-25 part, Radix Paeoniae Rubra 10-20 part by weight, mix 5-1C minute to even;

(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.