CN102488882B - Compound propolis composition for treating porcine respiratory disease syndrome and preparation method thereof - Google Patents

Compound propolis composition for treating porcine respiratory disease syndrome and preparation method thereof Download PDF

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CN102488882B
CN102488882B CN201110446076.3A CN201110446076A CN102488882B CN 102488882 B CN102488882 B CN 102488882B CN 201110446076 A CN201110446076 A CN 201110446076A CN 102488882 B CN102488882 B CN 102488882B
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parts
composition
respiratory disease
porcine respiratory
radix
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CN102488882A (en
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周庆福
刘文利
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Qingdao Lvman Bioengineering Co Ltd
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Qingdao Lvman Bioengineering Co Ltd
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Abstract

A compound propolis composition for treating porcine respiratory disease syndrome and a preparation method thereof relate to the field of animal medicine. The composition of the invention is prepared by the following method: (1) carrying out ultramicro crushing respectively on various components (except an interferon) in the composition and sieving through a 700 mesh screen; (2) weighing 15-35 parts of propolis, 15-30 parts of tussilago, 10-35 parts of the bulb of fritillary, 15-40 parts of balloonflower root, 10-40 parts of anemarrhena and 10-35 parts of bitter apricot kernel; (3) weighing 10-35 parts of radix ophiopogonis, 15-45 parts of cape jasmine, 15-25 parts of licorice, 15-55 parts of gypsum, 15-35 parts of Chinese holly and 15-45 parts of ginger and mixing 5-10 min to a uniform state; and (4) merging the combinations prepared in the steps (2) and (3) and mixing 10-15 min to a uniform state. The invention has beneficial effects of reasonable composition and simple preparation; the composition has no toxic or side effect, pollution, medicament residual or drug resistance, and is processed by ultramicro crushing to realize a high bioavailability; and the composition has substantial curative effect and special efficacy on porcine respiratory disease syndrome according to clinic proving.

Description

A kind of compound bee-glue composition for the treatment of porcine respiratory disease complex and preparation method thereof
Technical field
The present invention relates to animal field of medicaments, particularly a kind of compound bee-glue composition that is specifically designed to treatment porcine respiratory disease complex and preparation method thereof.
Background technology
Porcine respiratory disease complex is that the porcine respiratory symptom and the pathological changes that by microorganism mixed infections such as multiple virus, antibacterials, are caused are main high lethal infectious disease.Cardinal symptom for cough, breathe and ventral breathing, pathological changes be take the damage of lung and lymph nodes of body as a whole and spleen enlargement as main.The less sickness rate of domestic animal age in days is higher, and case fatality rate is also higher, is generally between 10%-50%.Primary disease all can occur throughout the year, is one of principal disease of harm livestock culturing industry.
Western medical treatment mainly be take sterilizing and anti-virus as main, and the traditional Chinese medical science thinks that primary disease is mainly that pyretic toxicity amasss in the caused respiratory symptom of lung, belongs to interior-excess heat syndrome, and treatment should adopt the principle of heat-clearing and toxic substances removing, removing summer-heat lung-heat, relieving cough and asthma.
This disease almost spreads all over the world all livestock culturings country, is widely distributed.At present, treat this disease the most frequently used be Chinese medicine and Western medicine, Chinese medicine is because its prescription is unreasonable or simple pulverizing just, particle diameter is excessive, drug release is slower, causes its bioavailability lower, clinical effectiveness is not fine; And antimicrobial drug is because its toxic and side effects by force, easily produces the problems such as drug resistance and drug residue in Western medicine, clinical practice is very limited, and antiviral Western medicine is due to its serious toxic and side effects with curative effect is poor bans use of.
Therefore research and develop that a kind of to treat the having no side effect of porcine respiratory disease complex, drug residue free, the specific medicament producing that has no drug resistance be one of this field scientific research technical staff new problem anxious to be resolved.
Summary of the invention
The object of the invention is to overcome above-mentioned weak point, provide that a kind of reasonable recipe, preparation are simple, micronizing, bioavailability are high, successful, have no side effect, have no drug resistance and the compound bee-glue composition of effective treatment porcine respiratory disease complex of drug residue and preparation method thereof.
Implementation of the present invention is as follows for achieving the above object: a kind of compound bee-glue composition for the treatment of porcine respiratory disease complex, by following component by weight mixed preparing form: propolis 15-35 part, Flos Farfarae 15-30 part, Bulbus Fritillariae Uninbracteatae 10-35 part, Radix Platycodonis 15-40 part, Rhizoma Anemarrhenae 10-40 part, Semen Armeniacae Amarum 10-35 part, Radix Ophiopogonis 10-35 part, Fructus Gardeniae 15-45 part, Radix Glycyrrhizae 15-35 part, Gypsum Fibrosum 15-55 part, Ilex purpurea Hassk.[I.chinensis Sims 15-35 part, Rhizoma Zingiberis Recens 15-45 part.
On the basis of such scheme, described various component optimum ratio amounts are: 25 parts of propolis, 25 parts of Flos Farfaraees, 20 parts of Bulbus Fritillariae Uninbracteataes, 25 parts of Radix Platycodoniss, 30 parts of the Rhizoma Anemarrhenaes, 25 parts of Semen Armeniacae Amarums, 25 parts of Radix Ophiopogonis, 30 parts of Fructus Gardeniaes, 25 parts, Radix Glycyrrhizae, 35 parts, Gypsum Fibrosum, 25 parts of Ilex purpurea Hassk.[I.chinensis Sims, 30 parts, Rhizoma Zingiberis Recens.
Treat a preparation method for the compound bee-glue composition of porcine respiratory disease complex, carry out as follows:
(1) the various compositions (except interferon) in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight propolis 15-35 part, Flos Farfarae 15-30 part, Bulbus Fritillariae Uninbracteatae 10-35 part, Radix Platycodonis 15-40 part, Rhizoma Anemarrhenae 10-40 part, Semen Armeniacae Amarum 10-35 part, mix 5-10 minute to even;
(3) take by weight 10-35 part Radix Ophiopogonis, Fructus Gardeniae 15-45 part, Radix Glycyrrhizae 15-35 part, Gypsum Fibrosum 15-55 part, Ilex purpurea Hassk.[I.chinensis Sims 15-35 part, Rhizoma Zingiberis Recens 15-45 part, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
The medicinal property of each component is as follows:
Propolis: bitter, acrid, cold, return spleen, lung, stomach warp, there is anti-bacteria and anti-virus, antalgesic-antipruritic, promotion tissue regeneration, improve immunity, antiallergic is oxidized, stop blooding, moisturize, the function of relieving cough and asthma, protection gastrointestinal mucosa.
Flos Farfarae: micro-hardship, pungent, warm, return lung meridian, there is the function of nourishing the lung to keep the adverse QI downward, relieving cough and resolving phlegm; Cure mainly cough, asthma etc.
Bulbus Fritillariae Cirrhosae: bitter, sweet, be slightly cold, return lung, heart channel, there is the function of clearing heat and moistening lung, relieving cough and resolving phlegm, eliminating stagnation eliminating carbuncle; Cure mainly lung-heat type cough, the few expectorant of chronic cough, sore and toxic, acute mastitis etc.
Fructus Gardeniae: bitter, cold, GUIXIN, lung, tri-jiao channel, have the function of eliminating fire and detoxication, clearing away heat and promoting diuresis, removing heat from blood; Cure mainly three warmers intenseness of heat, jaundice due to damp-heat, pyretic stranguria, aphtha of the mouth and tongue, conjunctival congestion and swelling pain, heat in blood epistaxis etc.
Radix Glycyrrhizae: sweet, flat, return lung, the heart, spleen channel, there is invigorating the spleen and replenishing QI, expelling phlegm for arresting cough and middle emergency, removing toxic substances, coordinating the actions of various ingredients in a prescription, cushion toxicity, strong function; Cure mainly weakness of the spleen and stomach, cough with asthma, poisoning.
Radix Platycodonis: bitter, pungent, flat, return lung meridian, there is lung qi dispersing, eliminate the phlegm, the function of sore-throat relieving, evacuation of pus; Cure mainly cough with copious phlegm, laryngopharynx swelling and pain, lung abscess etc.
Semen Armeniacae Amarum: bitter, tepor, return lung, large intestine channel, there is the function of relieving cough and asthma, loosening bowel to relieve constipation; Cure mainly cough and asthma, dryness of the intestine constipation etc.
The Rhizoma Anemarrhenae: bitter, sweet, cold, return lung, stomach, kidney channel, there is clearing away heat-fire, nourshing Yin and drynsessmoistening prescription function; Cure mainly fever caused by exogenous pathogenic factors, gastric heat, cough due to lung-heat, dryness of the intestine constipation, yin asthenia generating intrinsic heat etc.
Gypsum Fibrosum: sweet, pungent, cold, attach to the lung and stomach meridians, there is the function of clearing away heat-fire, promoting the production of body fluid to quench thirst; Cure mainly fever caused by exogenous pathogenic factors, lung-heat dyspnea with rapid and short breath, the greedy drink of gastric heat, high fever coma, manic uneasiness etc.
Rhizoma Zingiberis Recens: pungent, tepor, return lung, spleen, stomach warp, there is the function of the cold expelling that induces sweat, warming middle-JIAO to arrest vomiting, preventing phlegm from forming and stopping coughing; Cure mainly affection of exogenous wind-cold, gastrofrigid vomiting, cold-phlegm cough etc.
Ilex purpurea Hassk.[I.chinensis Sims: bitter, puckery, cool, return lung, large intestine, urinary bladder channel, there is the function of heat-clearing and toxic substances removing, detumescence blood stasis dispelling; Cure mainly lung-heat cough with asthma, laryngopharynx swelling and pain, damp-heat diarrhea etc.
Radix Ophiopogonis: micro-hardship, sweet, be slightly cold, return lung, the heart, stomach warp, there is the function that YIN nourishing and the production of body fluid promoting, lung moistening clear away heart-fire; Cure mainly yin asthenia generating intrinsic heat, dryness of the lung dry cough, dryness of the intestine constipation etc.
All taste Chinese medicine, according to Chinese medical theory compatible combination, for paathogenic factor and the clinical symptoms of porcine respiratory disease complex, is brought into play the effect for the treatment of both the principal and secondary aspects of a disease above.
The invention has the beneficial effects as follows: reasonable recipe, preparation is simple, and substep mixes more even; Chinese medicine composition is pollution-free, have no side effect, no drug residue, have no drug resistance, and cost is low, draws materials wide, and micronizing, bioavailability are high, curative effect highly significant.The present invention is according to Chinese veterinarian's traditional theory, optimize this 12 taste Chinese medicine, and make them according to optimum ratio, form pure Chinese powder medicine, clinical practice proves, treatment porcine respiratory disease complex is had to specially good effect, and make its product meat reach nuisanceless requirement, meet the export standard of product, effectively guaranteed that people's is healthy.
The specific embodiment
Below in conjunction with preferred embodiment, to according to the specific embodiment provided by the invention, details are as follows:
Embodiment 1
A kind of compound bee-glue composition for the treatment of porcine respiratory disease complex and preparation method thereof: carry out as follows: (every part by 10g)
(1) the various compositions (except interferon) in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight 150 parts of propolis, 150 parts of Flos Farfaraees, 100 parts of Bulbus Fritillariae Uninbracteataes, 150 parts of Radix Platycodoniss, 100 parts of the Rhizoma Anemarrhenaes, 100 parts of Semen Armeniacae Amarums, mix 5-10 minute to even;
(3) take by weight 100 parts of Radix Ophiopogonis, 150 parts of Fructus Gardeniaes, 150 parts, Radix Glycyrrhizae, 150 parts, Gypsum Fibrosum, 150 parts of Ilex purpurea Hassk.[I.chinensis Sims, 150 parts, Rhizoma Zingiberis Recens, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Embodiment 2
A kind of compound bee-glue composition for the treatment of porcine respiratory disease complex and preparation method thereof: carry out as follows: (every part by 10g)
(1) the various compositions (except interferon) in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight 250 parts of propolis, 250 parts of Flos Farfaraees, 250 parts of Bulbus Fritillariae Uninbracteataes, 250 parts of Radix Platycodoniss, 250 parts of the Rhizoma Anemarrhenaes, 250 parts of Semen Armeniacae Amarums, mix 5-10 minute to even;
(3) take by weight 250 parts of Radix Ophiopogonis, 300 parts of Fructus Gardeniaes, 250 parts, Radix Glycyrrhizae, 350 parts, Gypsum Fibrosum, 250 parts of Ilex purpurea Hassk.[I.chinensis Sims, 300 parts, Rhizoma Zingiberis Recens, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Embodiment 3
A kind of compound bee-glue composition for the treatment of porcine respiratory disease complex and preparation method thereof: carry out as follows: (every part by 10g)
(1) the various compositions (except interferon) in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight 350 parts of propolis, 300 parts of Flos Farfaraees, 350 parts of Bulbus Fritillariae Uninbracteataes, 400 parts of Radix Platycodoniss, 400 parts of the Rhizoma Anemarrhenaes, 350 parts of Semen Armeniacae Amarums, mix 5-10 minute to even;
(3) take by weight 350 parts of Radix Ophiopogonis, 450 parts of Fructus Gardeniaes, 350 parts, Radix Glycyrrhizae, 550 parts, Gypsum Fibrosum, 350 parts of Ilex purpurea Hassk.[I.chinensis Sims, 450 parts, Rhizoma Zingiberis Recens, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
Clinical trial:
By the ill pig of product feeding of the present invention etc., a day dose is: by the every 100g of the present invention, spice 220kg feeds, and the 400kg that drinks water, every day 2-3 time, is used in conjunction 3-5 day; After oral, by gastrointestinal absorption, reach the object for the treatment of disease.
Table is the field applicable cases contrast of the present invention and other medicines treatment porcine respiratory disease complex:
Numbering Group Mortality rate % Cure rate % During end, there is symptom rate %
I Blank group 33.8 33.6 32.6
II Asthma relieving powder group 12.4 69.1 18.5
III Present composition group 7.7 83.9 8.4
This clinical effectiveness statistical analysis, present composition treatment group is being compared difference extremely significantly (P < 0.01) with asthma relieving powder group aspect cure rate.
Above-mentioned detailed description of compound bee-glue composition of this treatment porcine respiratory disease complex and preparation method thereof being carried out with reference to embodiment; illustrative rather than determinate; can list several embodiment according to institute's limited range; therefore in the variation and the modification that do not depart under general plotting of the present invention, within should belonging to protection scope of the present invention.

Claims (3)

1. treat a compound bee-glue composition for porcine respiratory disease complex, it is characterized in that by following component by weight mixed preparing form: propolis 15-35 part, Flos Farfarae 15-30 part, Bulbus Fritillariae Uninbracteatae 10-35 part, Radix Platycodonis 15-40 part, Rhizoma Anemarrhenae 10-40 part, Semen Armeniacae Amarum 10-35 part, Radix Ophiopogonis 10-35 part, Fructus Gardeniae 15-45 part, Radix Glycyrrhizae 15-35 part, Gypsum Fibrosum 15-55 part, Ilex purpurea Hassk.[I.chinensis Sims 15-35 part, Rhizoma Zingiberis Recens 15-45 part.
2. the compound bee-glue composition for the treatment of porcine respiratory disease complex according to claim 1, it is characterized in that by following component by weight mixed preparing form: 25 parts of propolis, 25 parts of Flos Farfaraees, 20 parts of Bulbus Fritillariae Uninbracteataes, 25 parts of Radix Platycodoniss, 30 parts of the Rhizoma Anemarrhenaes, 25 parts of Semen Armeniacae Amarums, 25 parts of Radix Ophiopogonis, 30 parts of Fructus Gardeniaes, 25 parts, Radix Glycyrrhizae, 35 parts, Gypsum Fibrosum, 25 parts of Ilex purpurea Hassk.[I.chinensis Sims, 30 parts, Rhizoma Zingiberis Recens.
3. a preparation method for the compound bee-glue composition for the treatment of porcine respiratory disease complex according to claim 1, is characterized in that carrying out as follows:
(1) the various compositions in prescription are crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight propolis 15-35 part, Flos Farfarae 15-30 part, Bulbus Fritillariae Uninbracteatae 10-35 part, Radix Platycodonis 15-40 part, Rhizoma Anemarrhenae 10-40 part, Semen Armeniacae Amarum 10-35 part, mix 5-10 minute to even;
(3) take by weight 10-35 part Radix Ophiopogonis, Fructus Gardeniae 15-45 part, Radix Glycyrrhizae 15-35 part, Gypsum Fibrosum 15-55 part, Ilex purpurea Hassk.[I.chinensis Sims 15-35 part, Rhizoma Zingiberis Recens 15-45 part, mix 5-10 minute to even;
(4) merge the compositions that above-mentioned (2), (3) step make, continue to mix 10-15 minute to even.
CN201110446076.3A 2011-12-28 2011-12-28 Compound propolis composition for treating porcine respiratory disease syndrome and preparation method thereof Expired - Fee Related CN102488882B (en)

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CN109700927A (en) * 2019-02-21 2019-05-03 郑州赛科药业科技有限公司 It prevents and treats poison and invades Chinese medicine composition and preparation method that lung defends type porcine reproductive and respiratory syndrome

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