CN103735909B - A kind of compound preparation for the treatment of animal lung heat and preparation method thereof - Google Patents
A kind of compound preparation for the treatment of animal lung heat and preparation method thereof Download PDFInfo
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- CN103735909B CN103735909B CN201410020708.3A CN201410020708A CN103735909B CN 103735909 B CN103735909 B CN 103735909B CN 201410020708 A CN201410020708 A CN 201410020708A CN 103735909 B CN103735909 B CN 103735909B
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Abstract
The invention discloses a kind of compound preparation for the treatment of animal lung heat, it is made up of Herba Schizonepetae, Radix Asteris, Caulis Bambusae In Taeniam, Fructus Citri Limoniae, Flos Eriobotryae, Caulis Bambusae In Taenia, Semen Celosiae, Caulis Cucurbitae, Radix Polygalae, Flos Eriocauli, Radix Glycyrrhizae, Fructus Crataegi; The present invention is according to each component characteristic, and after each component first being carried out just extraction, extract micronizing after mixing obtains.The present invention has scientific formula, and technique is rigorous, and curative effect is excellent, effectively can treat the advantages such as animal lung heat.
Description
Technical field
The present invention relates to field of veterinary, be specifically related to a kind of compound preparation for the treatment of animal lung heat and preparation method thereof.
Background technology
Lung-heat is flourishing also known as excess-heat of the lung, lung-fire, lung-heat.Lung is contained in and disease belongs to real person in pathogenic heat.How because affection due to external wind and heat violates lung, or heat-transformation in the evil people of wind and cold, pent up caused by the lung, also can be caused by interior-heat.With exuberant evil_heat, impairment of purifying function of the lung, the lung system excess-heat of disorder of QI movement and impairment of body fluid consumption liquid are main pathological change.Thermal burn lung Tianjin, refining liquid is expectorant, then expectorant and accumulation of heat, stops up and hinders in lung.On lung-heat, smoked throat, stops up stagnant QI and blood.Then red swelling and pain of throat.
The pneumonia of the similar modern medicine of pyretic pulmonary disease is the pulmonary parenchyma inflammation caused by pathogenic microorganism or other factors.Lung-heat is a kind of disease that pulmonary's pus infections is formed.Clinical many with heating, cough, chest pain, the amount of coughing up phlegm, abnormal smells from the patient is smelt as of rotten fish, or pus and blood is held concurrently mutually as cardinal symptom.
The angle treated from differentiation of tcm is analyzed, lung-heat internal organs excess syndrome pathogenesis key is exopathogen invasion and attack human body, and lung stands in the breach, and lung then loses by heresy the merit that Xuan Fasu falls, the function of large intestine conduction waste matter is restricted, internal organs gas must not lead to, exopathogen invading the interior heat-transformation, is harmonious with the scorching of large intestine, consumed with bringing about the spread of body fluid, dryness accumulated in the stomach and intestine becomes real, block in, namely produce hectic fever, constipation, abdominal distention and the cards such as pain, deep and forceful pulse.In line with the basic theory of tcm of " the lung and the large intestine being interior-exteriorly related ", " lung heat clearing needs purging FU-organs; internal organs gas leads to lung qi a surname ", therefore catharsis on Ying Yixuan, internal organs are ruled together as principle for the treatment of, upper lung qi dispersing gas, lung qi is led to, to reach lung qi dispersing cough-relieving, the therapeutic effect of resolving phlegm and relieving asthma, lower purging FU-organs is real, make stagnant in internal organs being dredged, reach the therapeutic effect of removing burning wood away under the boiler, merge the real abdominal distention cardinal symptom of internal organs for pneumonia.
Current lung-heat is mainly based on the Therapeutic Method such as antibiotic, antiviral, although can the control section state of an illness, owing to excessively using clinically or abuse of antibiotics, Resistant strain constantly occurs.In addition, the problem such as drug residue also brings food safety and public health problem to the mankind.Chinese herbal medicine exactly can solve these difficult problems, and has the advantages such as aboundresources, cheap, toxic and side effects is little, more and more receives the concern of people.
Summary of the invention
The present invention is intended to solve prior art above shortcomings, and object is to provide a kind of compound preparation for the treatment of animal lung heat, its scientific formula, and proportioning is rigorous, and curative effect is excellent, effectively can treat animal lung heat.
Another object of the present invention is to provide a kind of preparation method for the treatment of the compound preparation of animal lung heat, and it, according to the characteristic of each raw material, extracts pulverizing layer by layer, and technique is rigorous, effectively can extract the effective ingredient in raw material, thus improving product curative effect.
The technical scheme realizing above-mentioned purpose is:
Treat a compound preparation for animal lung heat, be made up of the raw material of following weight proportioning: Herba Schizonepetae 14-21 part, Radix Asteris 7-10 part, Caulis Bambusae In Taeniam 5-12 part, Fructus Citri Limoniae 2-9 part, Flos Eriobotryae 3-10 part, Caulis Bambusae In Taenia 8-16 part, Semen Celosiae 6-13 part, Caulis Cucurbitae 12-22 part, Radix Polygalae 11-24 part, Flos Eriocauli 7-13 part, Radix Glycyrrhizae 8-17 part, Fructus Crataegi 9-14 part;
A kind of preparation method for the treatment of the compound preparation of animal lung heat is as follows:
Get Herba Schizonepetae, Radix Polygalae, Flos Eriocauli pulverizing, cross 40 object sieves, interpolation Herba Schizonepetae, Radix Polygalae, Flos Eriocauli gross mass 16-24 volume fraction are doubly the ethanol of 85-95%, in 55-65 DEG C, supersound extraction 30-60min under 500-600W power, extracting solution, through filtration under diminished pressure, collects filtrate cool to room temperature, and it is for subsequent use that 1/4 final vacuum filtrate being concentrated into original volume is dried to Herba Schizonepetae-Radix Polygalae-Flos Eriocauli mixed extract powder;
Get Radix Asteris, Caulis Bambusae In Taeniam, Fructus Crataegi powder be broken to 40 orders, with the soak with ethanol 48h of volume fraction 80-95%, after soaking, residue uses volume fraction 95% ethanol water bath reflux, extract, 4h again, filter, filtering residue repeats extraction twice, merging filtrate, after merging filtrate being concentrated into original volume 1/3, then vacuum drying to obtain Radix Asteris-Caulis Bambusae In Taeniam-Fructus Crataegi mixed extract powder for subsequent use;
Being crushed to 100 orders after getting Fructus Citri Limoniae, Flos Eriobotryae, Caulis Bambusae In Taenia, Semen Celosiae, Caulis Cucurbitae, Radix Glycyrrhizae mixing, to obtain mixed-powder for subsequent use;
By Herba Schizonepetae-Radix Polygalae-Flos Eriocauli mixed extract powder, Radix Asteris-Caulis Bambusae In Taeniam-Fructus Crataegi mixed extract powder, mixed-powder mixing, micronizing obtains finished product.
The usage of this compound preparation is: add 1.2-1.5 kilogram of this product in animal feed per ton.
Each raw material effectiveness in prescription of the present invention is as follows:
Herba Schizonepetae: the pungent tepor of property, returns lung, Liver Channel.Have expelling pathogenic wind from the body surface, rash disappears effect of skin ulcer, hemostasis.Mainly be applicable to diseases caused by exogenous pathogenic factor exterior syndrome, measles without adequate eruption, rubella pruritus, skin infection has exterior syndrome concurrently from the beginning of blood, the treatment of hematemesis and epistaxis, hematochezia symptom.Study this product from modern medicine viewpoint, think that the main component such as piperitone contained by this product and a small amount of d-limonen plays Main Function in relieving cough and expelling phlegm.
Radix Asteris: its property of medicine toil, sweet, tepor, returns lung meridian.There is the function of moistening the lung and resolving phlegm cough-relieving.Mainly be applicable to bring up phlegm when one coughs the treatment of symptom.Study this product from modern medicine viewpoint to think: this product water decoction and benzene, methanolic extract have significant phlegm-dispelling functions, and main component of eliminating the phlegm is butyl-D-ribulose glycosides; In addition, in the extract of acting in accordance with YIN YANG changes in four seasons and rhizome, one of isolated crystallization also has cough-relieving effect.
Caulis Bambusae In Taeniam: sweet in the mouth; Micro-hardship; Cool in nature.Function: boosting qi and nourishing yin; Nourishing the lung to arrest cough; Clearing away heat-damp and promoting diuresis.Cure mainly: deficiency of the lung heat syndrome cough; Laryngitis; Dysentery; Leucorrhea; Hypertension; Hyperlipemia; Antineoplastic auxiliary treatment.
Fructus Citri Limoniae: sour in the mouth, sweet; Cool in nature; Gui Jing: enter lung; Stomach warp; Effect is promoting the production of body fluid to quench thirst; Stomach function regulating is antiabortive.Cure mainly gastric heat impairment of body fluid; Heatstroke excessive thirst; Inappetence; Gastral cavity abdomen painful abdominal mass is swollen; Pulmonary cough is coughed; Vomiting during pregnancy.
Flos Eriobotryae: lightly seasoned; Property is put down.Enter lung meridian.Dispelling wind cough-relieving, clearing the nasal passage.Cure mainly cold cough, nasal obstruction watery nasal discharge, asthenia chronic cough, sputum mixed with blood.
Caulis Bambusae In Taenia: sweet in the mouth; Cold nature.Gui Jing: spleen; Stomach; Gallbladder meridian.Function removing heat-phlegm; Relieve restlessness and prevent vomiting; Antiabortive removing heat from blood.Cure mainly cough due to lung-heat; Dysphoria with smothery sensation is palpitated with fear; Gastric heat is vomitted oh; Pregnancy reactions; Frequent fetal movement; Spit blood; Epistaxis; Hematuria; Metrorrhagia.
Semen Celosiae: bitter in the mouth; Cold nature.Effect: liver heat removing and eyesight improving, clearing away heat-fire, improving acuity of vision and removing nebula.Cure mainly: conjunctival congestion and swelling pain; Nebula of looking unfamiliar film; Blurring of vision; Hypertension; Epistaxis; Skin wind heat pruritus; Skin ulcer tinea.
Caulis Cucurbitae: sweet in the mouth; Bitter; Cold nature.Gui Jing: enter liver; Stomach; Lung meridian.Effect is lung heat clearing; Suppressing the hyperactive liver; Stomach function regulating; Dredging collateral.Cure mainly pulmonary tuberculosis low grade fever; Stomachache due to hyperactive liver-QI attacking the stomach; Menoxenia; Acute catarrhal conjunctivitis swelling pain; Burn due to hot liquid or fire.
Radix Polygalae: warm in nature, bitter in the mouth, pungent, the function of have Fructus Alpiniae Oxyphyllae of calming the nerves, eliminate the phlegm, subsiding a swelling, the insomnia and dreamful sleep caused for disarmony between the heart and kidney, forgetful palpitation with fear, staring spells, expectoration is not well, sore swollen toxin, breast swell and pain.
Flos Eriocauli: be the inflorescence of the band scape of Eriocaulaceae plant Flos Eriocauli.Its sweet in the mouth is put down, and enters liver, stomach warp, cures mainly corneal nebula, night blindness, headache, toothache, sore throat, epistaxis, improving acuity of vision and removing nebula.
Radix Glycyrrhizae: sweet in the mouth, property is put down.GUIXIN, lung, spleen, stomach warp.Effect is invigorating the spleen and replenishing QI, heat-clearing and toxic substances removing, expelling phlegm for arresting cough, relieving spasm to stop pain, coordinating the actions of various ingredients in a prescription.Cure mainly weakness of the spleen and stomach, fatigue and weakness, shortness of breath and palpitation, cough with copious phlegm, the anxious pain of gastral cavity abdomen, extremity contraction, carbuncle sore tumefacting virus, cushion toxicity, strong.
Fructus Crataegi: have another name called Fructus Pyri Pashiae, Rosaceae Crataegus, is used as medicine after drying, has that stomach invigorating, removing food stagnancyization are stagnant, the effect of dissipating blood stasis of having a respite.
Lung heat clearing is purged heat Chinese medicine Herba Schizonepetae, Radix Asteris, Caulis Bambusae In Taeniam, Fructus Citri Limoniae, Flos Eriobotryae, Caulis Bambusae In Taenia, Semen Celosiae, Caulis Cucurbitae, Radix Polygalae, Radix Glycyrrhizae by the present invention, the Fructus Crataegi of the Flos Eriocauli flat with sweet in the mouth, stomach invigorating removing food stagnancy carries out compatibility, each component is worked in coordination and can be reached synergism, heighten the effect of a treatment, find that this prescription effectively can treat animal lung heat through test, and the simple Chinese medicine increasing bitter cold lung heat clearing, or reduce Flos Eriocauli, Fructus Crataegi not only cannot strengthen drug effect, can reduce drug effect on the contrary; The present invention is according to the characteristic of each medical material in addition, choose different extracting method, after different process is carried out to medical material, then by each extract, the process of ground product mixing ultra micro, effective ingredient (active substance such as total flavones, Saponin) concentration in medical material is improved, thus improving product curative effect.
Specific embodiment
Below in conjunction with specific embodiment, the present invention is described further, to help understanding content of the present invention.
Embodiment 1:
Treat a compound preparation for animal lung heat, be made up of the raw material of following weight proportioning: Herba Schizonepetae 17 parts, Radix Asteris 8 parts, Caulis Bambusae In Taeniam 11 parts, 5 parts, Fructus Citri Limoniae, Flos Eriobotryae 6 parts, Caulis Bambusae In Taenia 13 parts, Semen Celosiae 11 parts, Caulis Cucurbitae 18 parts, Radix Polygalae 19 parts, Flos Eriocauli 10 parts, 14 parts, Radix Glycyrrhizae, Fructus Crataegi 12 parts;
A kind of preparation method for the treatment of the compound preparation of animal lung heat is as follows:
Get Herba Schizonepetae, Radix Polygalae, Flos Eriocauli pulverizing, cross 40 object sieves, the volume fraction of interpolation Herba Schizonepetae, Radix Polygalae, Flos Eriocauli gross mass 22 times is the ethanol of 90%, in 60 DEG C, supersound extraction 40min under 560W power, extracting solution, through filtration under diminished pressure, collects filtrate cool to room temperature, and it is for subsequent use that 1/4 final vacuum filtrate being concentrated into original volume is dried to Herba Schizonepetae-Radix Polygalae-Flos Eriocauli mixed extract powder;
Get Radix Asteris, Caulis Bambusae In Taeniam, Fructus Crataegi powder be broken to 40 orders, with the soak with ethanol 48h of volume fraction 85%, after soaking, residue uses volume fraction 95% ethanol water bath reflux, extract, 4h again, filter, filtering residue repeats extraction twice, merging filtrate, after merging filtrate being concentrated into original volume 1/3, then vacuum drying to obtain Radix Asteris-Caulis Bambusae In Taeniam-Fructus Crataegi mixed extract powder for subsequent use;
Being crushed to 100 orders after getting Fructus Citri Limoniae, Flos Eriobotryae, Caulis Bambusae In Taenia, Semen Celosiae, Caulis Cucurbitae, Radix Glycyrrhizae mixing, to obtain mixed-powder for subsequent use;
By Herba Schizonepetae-Radix Polygalae-Flos Eriocauli mixed extract powder, Radix Asteris-Caulis Bambusae In Taeniam-Fructus Crataegi mixed extract powder, mixed-powder mixing, micronizing obtains finished product.
Embodiment 2
Treat a compound preparation for animal lung heat, be made up of the raw material of following weight proportioning: Herba Schizonepetae 14 parts, Radix Asteris 7 parts, Caulis Bambusae In Taeniam 5 parts, 2 parts, Fructus Citri Limoniae, Flos Eriobotryae 3 parts, Caulis Bambusae In Taenia 8 parts, Semen Celosiae 6 parts, Caulis Cucurbitae 12 parts, Radix Polygalae 11 parts, Flos Eriocauli 7 parts, 8 parts, Radix Glycyrrhizae, Fructus Crataegi 9 parts;
A kind of preparation method for the treatment of the compound preparation of animal lung heat is as follows:
Get Herba Schizonepetae, Radix Polygalae, Flos Eriocauli pulverizing, cross 40 object sieves, the volume fraction of interpolation Herba Schizonepetae, Radix Polygalae, Flos Eriocauli gross mass 16 times is the ethanol of 85%, in 55 DEG C, supersound extraction 30min under 500W power, extracting solution, through filtration under diminished pressure, collects filtrate cool to room temperature, and it is for subsequent use that 1/4 final vacuum filtrate being concentrated into original volume is dried to Herba Schizonepetae-Radix Polygalae-Flos Eriocauli mixed extract powder;
Get Radix Asteris, Caulis Bambusae In Taeniam, Fructus Crataegi powder be broken to 40 orders, with the soak with ethanol 48h of volume fraction 80%, after soaking, residue uses volume fraction 95% ethanol water bath reflux, extract, 4h again, filter, filtering residue repeats extraction twice, merging filtrate, after merging filtrate being concentrated into original volume 1/3, then vacuum drying to obtain Radix Asteris-Caulis Bambusae In Taeniam-Fructus Crataegi mixed extract powder for subsequent use;
Being crushed to 100 orders after getting Fructus Citri Limoniae, Flos Eriobotryae, Caulis Bambusae In Taenia, Semen Celosiae, Caulis Cucurbitae, Radix Glycyrrhizae mixing, to obtain mixed-powder for subsequent use;
By Herba Schizonepetae-Radix Polygalae-Flos Eriocauli mixed extract powder, Radix Asteris-Caulis Bambusae In Taeniam-Fructus Crataegi mixed extract powder, mixed-powder mixing, micronizing obtains finished product.
Embodiment 3
Treat a compound preparation for animal lung heat, be made up of the raw material of following weight proportioning: Herba Schizonepetae 21 parts, Radix Asteris 10 parts, Caulis Bambusae In Taeniam 12 parts, 9 parts, Fructus Citri Limoniae, Flos Eriobotryae 10 parts, Caulis Bambusae In Taenia 16 parts, Semen Celosiae 13 parts, Caulis Cucurbitae 22 parts, Radix Polygalae 24 parts, Flos Eriocauli 13 parts, 17 parts, Radix Glycyrrhizae, Fructus Crataegi 14 parts;
A kind of preparation method for the treatment of the compound preparation of animal lung heat is as follows:
Get Herba Schizonepetae, Radix Polygalae, Flos Eriocauli pulverizing, cross 40 object sieves, the volume fraction of interpolation Herba Schizonepetae, Radix Polygalae, Flos Eriocauli gross mass 24 times is the ethanol of 95%, in 65 DEG C, supersound extraction 60min under 600W power, extracting solution, through filtration under diminished pressure, collects filtrate cool to room temperature, and it is for subsequent use that 1/4 final vacuum filtrate being concentrated into original volume is dried to Herba Schizonepetae-Radix Polygalae-Flos Eriocauli mixed extract powder;
Get Radix Asteris, Caulis Bambusae In Taeniam, Fructus Crataegi powder be broken to 40 orders, with the soak with ethanol 48h of volume fraction 95%, after soaking, residue uses volume fraction 95% ethanol water bath reflux, extract, 4h again, filter, filtering residue repeats extraction twice, merging filtrate, after merging filtrate being concentrated into original volume 1/3, then vacuum drying to obtain Radix Asteris-Caulis Bambusae In Taeniam-Fructus Crataegi mixed extract powder for subsequent use;
Being crushed to 100 orders after getting Fructus Citri Limoniae, Flos Eriobotryae, Caulis Bambusae In Taenia, Semen Celosiae, Caulis Cucurbitae, Radix Glycyrrhizae mixing, to obtain mixed-powder for subsequent use;
By Herba Schizonepetae-Radix Polygalae-Flos Eriocauli mixed extract powder, Radix Asteris-Caulis Bambusae In Taeniam-Fructus Crataegi mixed extract powder, mixed-powder mixing, micronizing obtains finished product.
Embodiment 4
Treat a compound preparation for animal lung heat, be made up of the raw material of following weight proportioning: Herba Schizonepetae 11 parts, Radix Asteris 5 parts, Caulis Bambusae In Taeniam 7 parts, 11 parts, Fructus Citri Limoniae, Flos Eriobotryae 12 parts, Caulis Bambusae In Taenia 6 parts, Semen Celosiae 5 parts, Caulis Cucurbitae 10 parts, Radix Polygalae 10 parts, Flos Eriocauli 5 parts, 20 parts, Radix Glycyrrhizae, Fructus Crataegi 8 parts;
A kind of preparation method for the treatment of the compound preparation of animal lung heat is as follows:
Get Herba Schizonepetae, Radix Polygalae, Flos Eriocauli pulverizing, cross 40 object sieves, the volume fraction of interpolation Herba Schizonepetae, Radix Polygalae, Flos Eriocauli gross mass 13 times is the ethanol of 80%, in 50 DEG C, supersound extraction 20min under 400W power, extracting solution, through filtration under diminished pressure, collects filtrate cool to room temperature, and it is for subsequent use that 1/4 final vacuum filtrate being concentrated into original volume is dried to Herba Schizonepetae-Radix Polygalae-Flos Eriocauli mixed extract powder;
Get Radix Asteris, Caulis Bambusae In Taeniam, Fructus Crataegi powder be broken to 40 orders, with the soak with ethanol 48h of volume fraction 70%, after soaking, residue uses volume fraction 95% ethanol water bath reflux, extract, 4h again, filter, filtering residue repeats extraction twice, merging filtrate, after merging filtrate being concentrated into original volume 1/3, then vacuum drying to obtain Radix Asteris-Caulis Bambusae In Taeniam-Fructus Crataegi mixed extract powder for subsequent use;
Being crushed to 100 orders after getting Fructus Citri Limoniae, Flos Eriobotryae, Caulis Bambusae In Taenia, Semen Celosiae, Caulis Cucurbitae, Radix Glycyrrhizae mixing, to obtain mixed-powder for subsequent use;
By Herba Schizonepetae-Radix Polygalae-Flos Eriocauli mixed extract powder, Radix Asteris-Caulis Bambusae In Taeniam-Fructus Crataegi mixed extract powder, mixed-powder mixing, micronizing obtains finished product.
Embodiment 5
Treat a compound preparation for animal lung heat, be made up of the raw material of following weight proportioning: Herba Schizonepetae 23 parts, Radix Asteris 12 parts, Caulis Bambusae In Taeniam 14 parts, 10 parts, Fructus Citri Limoniae, Flos Eriobotryae 12 parts, Caulis Bambusae In Taenia 5 parts, Semen Celosiae 4 parts, Caulis Cucurbitae 8 parts, Radix Polygalae 25 parts, Flos Eriocauli 15 parts, 6 parts, Radix Glycyrrhizae, Fructus Crataegi 16 parts;
A kind of preparation method for the treatment of the compound preparation of animal lung heat is as follows:
Get Herba Schizonepetae, Radix Polygalae, Flos Eriocauli pulverizing, cross 40 object sieves, the volume fraction of interpolation Herba Schizonepetae, Radix Polygalae, Flos Eriocauli gross mass 27 times is the ethanol of 95%, in 75 DEG C, supersound extraction 70min under 700W power, extracting solution, through filtration under diminished pressure, collects filtrate cool to room temperature, and it is for subsequent use that 1/4 final vacuum filtrate being concentrated into original volume is dried to Herba Schizonepetae-Radix Polygalae-Flos Eriocauli mixed extract powder;
Get Radix Asteris, Caulis Bambusae In Taeniam, Fructus Crataegi powder be broken to 40 orders, with the soak with ethanol 48h of volume fraction 80-95%, after soaking, residue uses volume fraction 95% ethanol water bath reflux, extract, 4h again, filter, filtering residue repeats extraction twice, merging filtrate, after merging filtrate being concentrated into original volume 1/3, then vacuum drying to obtain Radix Asteris-Caulis Bambusae In Taeniam-Fructus Crataegi mixed extract powder for subsequent use;
Being crushed to 100 orders after getting Fructus Citri Limoniae, Flos Eriobotryae, Caulis Bambusae In Taenia, Semen Celosiae, Caulis Cucurbitae, Radix Glycyrrhizae mixing, to obtain mixed-powder for subsequent use;
By Herba Schizonepetae-Radix Polygalae-Flos Eriocauli mixed extract powder, Radix Asteris-Caulis Bambusae In Taeniam-Fructus Crataegi mixed extract powder, mixed-powder mixing, micronizing obtains finished product.
Comparative example 1
Treat a compound preparation for animal lung heat, be made up of the raw material of following weight proportioning: Herba Schizonepetae 17 parts, Radix Asteris 8 parts, Caulis Bambusae In Taeniam 11 parts, 5 parts, Fructus Citri Limoniae, Flos Eriobotryae 6 parts, Caulis Bambusae In Taenia 13 parts, Semen Celosiae 11 parts, Caulis Cucurbitae 18 parts, Radix Polygalae 19 parts, Flos Eriocauli 10 parts, 14 parts, Radix Glycyrrhizae, Fructus Crataegi 12 parts, Flos Lonicerae 9 parts, Herba Houttuyniae 5 parts, Folium Isatidis 6 parts, Herba Taraxaci 3 parts;
A kind of preparation method for the treatment of the compound preparation of animal lung heat is as follows:
Get Herba Schizonepetae, Radix Polygalae, Flos Eriocauli pulverizing, cross 40 object sieves, the volume fraction of interpolation Herba Schizonepetae, Radix Polygalae, Flos Eriocauli gross mass 22 times is the ethanol of 90%, in 60 DEG C, supersound extraction 40min under 560W power, extracting solution, through filtration under diminished pressure, collects filtrate cool to room temperature, and it is for subsequent use that 1/4 final vacuum filtrate being concentrated into original volume is dried to Herba Schizonepetae-Radix Polygalae-Flos Eriocauli mixed extract powder;
Get Radix Asteris, Caulis Bambusae In Taeniam, Fructus Crataegi powder be broken to 40 orders, with the soak with ethanol 48h of volume fraction 85%, after soaking, residue uses volume fraction 95% ethanol water bath reflux, extract, 4h again, filter, filtering residue repeats extraction twice, merging filtrate, after merging filtrate being concentrated into original volume 1/3, then vacuum drying to obtain Radix Asteris-Caulis Bambusae In Taeniam-Fructus Crataegi mixed extract powder for subsequent use;
Being crushed to 100 orders after getting Fructus Citri Limoniae, Flos Eriobotryae, Caulis Bambusae In Taenia, Semen Celosiae, Caulis Cucurbitae, Radix Glycyrrhizae, Flos Lonicerae, Herba Houttuyniae, Folium Isatidis, Herba Taraxaci mixing, to obtain mixed-powder for subsequent use;
By Herba Schizonepetae-Radix Polygalae-Flos Eriocauli mixed extract powder, Radix Asteris-Caulis Bambusae In Taeniam-Fructus Crataegi mixed extract powder, mixed-powder mixing, micronizing obtains finished product.
Comparative example 2
Treat a compound preparation for animal lung heat, be made up of the raw material of following weight proportioning: Herba Schizonepetae 17 parts, Radix Asteris 8 parts, Caulis Bambusae In Taeniam 11 parts, 5 parts, Fructus Citri Limoniae, Flos Eriobotryae 6 parts, Caulis Bambusae In Taenia 13 parts, Semen Celosiae 11 parts, Caulis Cucurbitae 18 parts, Radix Polygalae 19 parts, 14 parts, Radix Glycyrrhizae;
A kind of preparation method for the treatment of the compound preparation of animal lung heat is as follows:
Get Herba Schizonepetae, Radix Polygalae is pulverized, cross 40 object sieves, the volume fraction of interpolation Herba Schizonepetae, Radix Polygalae gross mass 22 times is the ethanol of 90%, in 60 DEG C, supersound extraction 40min under 560W power, extracting solution, through filtration under diminished pressure, collects filtrate cool to room temperature, and it is for subsequent use that 1/4 final vacuum filtrate being concentrated into original volume is dried to Herba Schizonepetae-Radix Polygalae mixed extract powder;
Get Radix Asteris, Caulis Bambusae In Taeniam is crushed to 40 orders, with the soak with ethanol 48h of volume fraction 85%, after soaking, residue uses volume fraction 95% ethanol water bath reflux, extract, 4h again, filter, filtering residue repeats extraction twice, merging filtrate, after merging filtrate being concentrated into original volume 1/3, then vacuum drying to obtain Radix Asteris-Caulis Bambusae In Taeniam mixed extract powder for subsequent use;
Being crushed to 100 orders after getting Fructus Citri Limoniae, Flos Eriobotryae, Caulis Bambusae In Taenia, Semen Celosiae, Caulis Cucurbitae, Radix Glycyrrhizae mixing, to obtain mixed-powder for subsequent use;
By Herba Schizonepetae-Radix Polygalae mixed extract powder, Radix Asteris-Caulis Bambusae In Taeniam mixed extract powder, mixed-powder mixing, micronizing obtains finished product.
Comparative example 3
Treat a compound preparation for animal lung heat, be made up of the raw material of following weight proportioning: Herba Schizonepetae 17 parts, Radix Asteris 8 parts, Caulis Bambusae In Taeniam 11 parts, 5 parts, Fructus Citri Limoniae, Flos Eriobotryae 6 parts, Caulis Bambusae In Taenia 13 parts, Semen Celosiae 11 parts, Caulis Cucurbitae 18 parts, Radix Polygalae 19 parts, Flos Eriocauli 10 parts, 14 parts, Radix Glycyrrhizae, Fructus Crataegi 12 parts;
A kind of preparation method for the treatment of the compound preparation of animal lung heat is as follows:
Get Herba Schizonepetae, Radix Asteris, Caulis Bambusae In Taeniam, Fructus Citri Limoniae, Flos Eriobotryae, Caulis Bambusae In Taenia, Semen Celosiae, Caulis Cucurbitae, Radix Polygalae, Flos Eriocauli, Radix Glycyrrhizae, Fructus Crataegi pulverizing, cross 40 object sieves, the volume fraction of adding all raw material gross masses 22 times is the ethanol of 90%, in 60 DEG C, supersound extraction 40min under 560W power, extracting solution is through filtration under diminished pressure, and collect filtrate cool to room temperature, 1/4 final vacuum filtrate being concentrated into original volume is dried to mixed extract powder and obtains finished product.
Comparative example 4
Treat a compound preparation for animal lung heat, be made up of the raw material of following weight proportioning: Herba Schizonepetae 17 parts, Radix Asteris 8 parts, Caulis Bambusae In Taeniam 11 parts, 5 parts, Fructus Citri Limoniae, Flos Eriobotryae 6 parts, Caulis Bambusae In Taenia 13 parts, Semen Celosiae 11 parts, Caulis Cucurbitae 18 parts, Radix Polygalae 19 parts, Flos Eriocauli 10 parts, 14 parts, Radix Glycyrrhizae, Fructus Crataegi 12 parts;
A kind of preparation method for the treatment of the compound preparation of animal lung heat is as follows:
Get Herba Schizonepetae, Radix Asteris, Caulis Bambusae In Taeniam, Fructus Citri Limoniae, Flos Eriobotryae, Caulis Bambusae In Taenia, Semen Celosiae, Caulis Cucurbitae, Radix Polygalae, Flos Eriocauli, Radix Glycyrrhizae, Fructus Crataegi powder be broken to 40 orders, with the soak with ethanol 48h of volume fraction 70%, after soaking, residue uses volume fraction 95% ethanol water bath reflux, extract, 4h again, filter, filtering residue repeats extraction twice, merging filtrate, after merging filtrate being concentrated into original volume 1/3, then vacuum drying obtains mixed extract powder and obtains finished product.
Test example:
1, get healthy rat 110, male and female half and half, after adaptability environment raises 1 week, morning and evening every day each take temperature 1 time, continuous 3d, chooses body temperature fluctuation person within 0.5 DEG C and includes experiment in.Be divided into normal healthy controls group group, modeling matched group, embodiment 1-5 group, comparative example 1-4 group at random, often organize 10, male and female half and half.Before experiment, 3d morning and evening every day each take temperature 1 time, gets its meansigma methods as arm's length basis body temperature.Before modeling, 1d is to testing between tailend, and embodiment 1-5 group, comparative example 1-4 group morning and evening every day gavage give this product 20mg/Kg according to its quality, normal healthy controls group, the modeling matched group every day of gavage equivalent distilled water sooner or later.The change of record duration of test rat temperature, the results are shown in Table 1.
2, modeling: by ether inhalation by after rat light anesthesia, it is 1.0 × 10 that embodiment 1-5 group, comparative example 1-4 group, modeling matched group give concentration respectively
9/ mL streptococcus pneumoniae bacterium liquid 0.5mL/kg body weight, with syringe, bacterium liquid slowly being instilled rat nasal cavity, is 0.05mL/min to bacterium speed, every 12h to bacterium 1 time, continuous 3 times; What normal healthy controls group was corresponding gives normal saline.The situation such as breathing, activity, diet, hair color, spirit, defecation of rat is observed every day before, during and after experiment; Every day monitors rat temperature sooner or later, and Temperature changing the results are shown in Table 1.Model sets up latter 6th day, to 20% urethane solution of rats by intraperitoneal injection 10mL/kg, gets blood examination and surveys leukocyte, the results are shown in Table 2 in hepatic portal vein.
3, take out bilateral pulmonary, clean bloodstain, observe and substantially change under available light, finally lungs tissue 10% formalin fixed with normal saline, routine paraffin wax embeds, section, and Hematoxylin-eosin dyes, the pathological change of light Microscopic observation lungs.
Pathological change criterion: lungs Pathologic Observation result is divided into 3 grades.1 grade: alveolar wall is micro-to be thickened, peribronchial and lung intracavity have a small amount of serous effusion as seen, are mixed with a small amount of erythrocyte, neutrophil cell.2 grades: alveolar wall thickens obviously, alveolar space is full of the exudate of a large amount of erythrocyte and a certain amount of cellulose, neutrophil cell.3 grades: alveolar wall extensively thickens, alveolar space is linearly narrow, and be inside full of the exudate of erythrocyte and cellulose, neutrophil cell, result of the test is in table 3.
Symptom and sign: embodiment 1-5 group, comparative example 1-4 group activities in rats reduce, lethargy, crude yellow skin, crimson and dry tongue, diet reduces, oliguria yellow skin, is hard and dry, and has slight sound of stridulating during breathing, breathe big and heavy, the all toughness secretions of indivedual rat nose, occasionally has cough, shows substantially consistent with clinical macroscopical sign of lung-heat syndrome.Normal healthy controls group is without above-mentioned symptom.
Rat temperature change tested by table 1
| Group | Quantity (only) | Body temperature reaction height (DEG C) on the 1st after modeling | Body temperature reaction height (DEG C) on the 3rd after modeling | Body temperature reaction height (DEG C) on the 5th after modeling |
| Embodiment 1 | 10 | 0.03±0.04 | 0.11±0.12 | 0.04±0.07 |
| Embodiment 2 | 10 | 0.07±0.17 | 0.18±0.22 | 0.16±0.13 |
| Embodiment 3 | 10 | 0.05±0.15 | 0.22±0.19 | 0.17±0.20 |
| Embodiment 4 | 10 | 0.28±0.16 | 0.39±0.26 | 0.40±0.23 |
| Embodiment 5 | 10 | 0.36±0.22 | 0.33±0.15 | 0.34±0.27 |
| Comparative example 1 | 10 | 0.12±0.19 | 0.36±0.16 | 0.38±0.35 |
| Comparative example 2 | 10 | 0.42±0.16 | 0.50±0.31 | 0.49±0.14 |
| Comparative example 3 | 10 | 0.42±0.33 | 0.53±0.39 | 0.51±0.26 |
| Comparative example 4 | 10 | 0.40±0.27 | 0.67±0.28 | 0.56±0.32 |
| Modeling matched group | 10 | 0.40±0.22 | 1.14±0.36 | 1.17±0.28 |
| Normal healthy controls group | 10 | -0.12±0.15 | 0.11±0.22 | 0.25±0.18 |
As shown in Table 1, after modeling, embodiment 1-5, the rat temperature of comparative example 1-4 and modeling matched group all has rising in various degree, and in the change of modeling third body temperature obviously, compare the Temperature changing of modeling control rats, embodiment 1-5, comparative example 1-4 group Temperature changing amplitude is less, and embodiment 1-3 group Temperature changing amplitude is less than embodiment 4-5 group, embodiment 4-5 group is less than again comparative example 1-4 group, and embodiment 1 body temperature had obvious decline compared with the 3rd day on the 5th day in modeling, and the difference between embodiment 1-5 is mainly the proportioning of formula, and technological parameter, and the difference of embodiment 1-5 and comparative example is formula and process, visible the present invention has the effect for the treatment of lung-heat, and the processing technique of action effect and product and formula reasonability closely related.Only have the proportioning of rational formula and science, be aided with rational processing technique and technological parameter, drug effect just can be made to reach best.
White blood cell in rat body tested by table 2
| Group | Quantity (only) | Total white blood cells (10 9Individual/L) | Neutrophilic granulocyte (10 9Individual/L) | Lymphocyte (10 9Individual/L) |
| Embodiment 1 | 10 | 10.41±1.85 | 2.06±0.29 | 7.83±1.57 |
| Embodiment 2 | 10 | 10.58±2.01 | 2.12±0.46 | 8.24±1.42 |
| Embodiment 3 | 10 | 10.63±1.97 | 2.10±0.32 | 8.37±1.60 |
| Embodiment 4 | 10 | 11.45±1.92 | 2.18±0.40 | 8.85±1.48 |
| Embodiment 5 | 10 | 11.17±2.14 | 2.14±0.31 | 8.74±1.62 |
| Comparative example 1 | 10 | 13.03±2.08 | 2.56±0.29 | 10.19±1.53 |
| Comparative example 2 | 10 | 12.77±1.89 | 2.71±0.44 | 8.85±1.27 |
| Comparative example 3 | 10 | 13.54±1.08 | 2.99±0.19 | 9.38±1.25 |
| Comparative example 4 | 10 | 14.02±1.37 | 3.21±0.24 | 10.36±1.17 |
| Modeling matched group | 10 | 15.35±2.36 | 3.58±0.41 | 11.28±1.54 |
| Normal healthy controls group | 10 | 10.35±1.97 | 1.97±0.23 | 7.56±1.31 |
As shown in Table 2, after modeling, compare with normal healthy controls group rat, the leukocyte count of embodiment 1-5, comparative example 1-4 and modeling matched group has to be increased in various degree, and this may to carry out immunoreation to pathogenic microorganism in test rat body relevant.While Drug therapy takes effect, in body, leukocyte count can be tending towards normal.Treatment by Chinese herbs pyretic pulmonary disease, the mechanism of action is complicated, not simply superpose the Chinese medicine that bitter cold lung heat clearing purges heat just can, but need constantly test and checking, dialectical to combine with differential diagnosis of diseases could be determined rational formula and proportioning, process and parameter, in the extraneous embodiment 4-5 group of technical scheme of the present invention, the comparative example 1-4 group of different formulations and technique, therapeutic effect is all not as embodiment 1-3 group, and embodiment 1 weighs total white blood cells, neutrophilic granulocyte number and lymphocyte number and normal healthy controls group is the most close, visible embodiment 1 best results.
Table 3 is tested rat pathological grade and is compared
| Group | Quantity (only) | Grade |
| Embodiment 1 | 10 | 1.20±0.45 |
| Embodiment 2 | 10 | 1.20±0.37 |
| Embodiment 3 | 10 | 1.30±0.29 |
| Embodiment 4 | 10 | 1.60±0.51 |
| Embodiment 5 | 10 | 1.75±0.42 |
| Comparative example 1 | 10 | 1.90±0.39 |
| Comparative example 2 | 10 | 2.20±0.46 |
| Comparative example 3 | 10 | 2.15±0.38 |
| Comparative example 4 | 10 | 2.30±0.41 |
| Modeling matched group | 10 | 2.50±0.36 |
| Normal healthy controls group | 10 | 1.10±0.17 |
As shown in Table 3, the rat pathological grade of embodiment 1-3 group is obviously better than embodiment 4-5, comparative example 1-4 and modeling matched group, and visible the present invention effectively can treat animal lung heat, and by formula, rational technology combination, drug effect can reach optimum.
Claims (5)
1. treat a compound preparation for animal lung heat, be made up of the raw material of following weight proportioning: Herba Schizonepetae 14-21 part, Radix Asteris 7-10 part, Caulis Bambusae In Taeniam 5-12 part, Fructus Citri Limoniae 2-9 part, Flos Eriobotryae 3-10 part, Caulis Bambusae In Taenia 8-16 part, Semen Celosiae 6-13 part, Caulis Cucurbitae 12-22 part, Radix Polygalae 11-24 part, Flos Eriocauli 7-13 part, Radix Glycyrrhizae 8-17 part, Fructus Crataegi 9-14 part.
2. a kind of compound preparation for the treatment of animal lung heat according to claim 1, is made up of the raw material of following weight proportioning: Herba Schizonepetae 17 parts, Radix Asteris 8 parts, Caulis Bambusae In Taeniam 11 parts, 5 parts, Fructus Citri Limoniae, Flos Eriobotryae 6 parts, Caulis Bambusae In Taenia 13 parts, Semen Celosiae 11 parts, Caulis Cucurbitae 18 parts, Radix Polygalae 19 parts, Flos Eriocauli 10 parts, 14 parts, Radix Glycyrrhizae, Fructus Crataegi 12 parts.
3. a kind of compound preparation for the treatment of animal lung heat according to claim 1 and 2, its preparation method is as follows:
Get Herba Schizonepetae, Radix Polygalae, Flos Eriocauli pulverizing, cross 40 object sieves, interpolation Herba Schizonepetae, Radix Polygalae, Flos Eriocauli gross mass 16-24 volume fraction are doubly the ethanol of 85-95%, in 55-65 DEG C, supersound extraction 30-60min under 500-600W power, extracting solution, through filtration under diminished pressure, collects filtrate cool to room temperature, and it is for subsequent use that 1/4 final vacuum filtrate being concentrated into original volume is dried to Herba Schizonepetae-Radix Polygalae-Flos Eriocauli mixed extract powder;
Get Radix Asteris, Caulis Bambusae In Taeniam, Fructus Crataegi powder be broken to 40 orders, with the soak with ethanol 48h of volume fraction 80-95%, after soaking, residue uses volume fraction 95% ethanol water bath reflux, extract, 4h again, filter, filtering residue repeats extraction twice, merging filtrate, after merging filtrate being concentrated into original volume 1/3, then vacuum drying to obtain Radix Asteris-Caulis Bambusae In Taeniam-Fructus Crataegi mixed extract powder for subsequent use;
Being crushed to 100 orders after getting Fructus Citri Limoniae, Flos Eriobotryae, Caulis Bambusae In Taenia, Semen Celosiae, Caulis Cucurbitae, Radix Glycyrrhizae mixing, to obtain mixed-powder for subsequent use;
By Herba Schizonepetae-Radix Polygalae-Flos Eriocauli mixed extract powder, Radix Asteris-Caulis Bambusae In Taeniam-Fructus Crataegi mixed extract powder, mixed-powder mixing, micronizing obtains finished product.
4. a kind of compound preparation for the treatment of animal lung heat according to claim 3, its preparation method is as follows:
Get Herba Schizonepetae, Radix Polygalae, Flos Eriocauli pulverizing, cross 40 object sieves, the volume fraction of interpolation Herba Schizonepetae, Radix Polygalae, Flos Eriocauli gross mass 22 times is the ethanol of 90%, in 60 DEG C, supersound extraction 40min under 560W power, extracting solution, through filtration under diminished pressure, collects filtrate cool to room temperature, and it is for subsequent use that 1/4 final vacuum filtrate being concentrated into original volume is dried to Herba Schizonepetae-Radix Polygalae-Flos Eriocauli mixed extract powder;
Get Radix Asteris, Caulis Bambusae In Taeniam, Fructus Crataegi powder be broken to 40 orders, with the soak with ethanol 48h of volume fraction 85%, after soaking, residue uses volume fraction 95% ethanol water bath reflux, extract, 4h again, filter, filtering residue repeats extraction twice, merging filtrate, after merging filtrate being concentrated into original volume 1/3, then vacuum drying to obtain Radix Asteris-Caulis Bambusae In Taeniam-Fructus Crataegi mixed extract powder for subsequent use;
Being crushed to 100 orders after getting Fructus Citri Limoniae, Flos Eriobotryae, Caulis Bambusae In Taenia, Semen Celosiae, Caulis Cucurbitae, Radix Glycyrrhizae mixing, to obtain mixed-powder for subsequent use;
By Herba Schizonepetae-Radix Polygalae-Flos Eriocauli mixed extract powder, Radix Asteris-Caulis Bambusae In Taeniam-Fructus Crataegi mixed extract powder, mixed-powder mixing, micronizing obtains finished product.
5. a kind of compound preparation for the treatment of animal lung heat according to claim 1, its using method is: add 1.2-1.5 kilogram of said preparation in animal feed per ton.
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| CN102488882A (en) * | 2011-12-28 | 2012-06-13 | 青岛绿曼生物工程有限公司 | Compound propolis composition for treating porcine respiratory disease syndrome and preparation method thereof |
| CN102988862A (en) * | 2012-12-17 | 2013-03-27 | 凤台县中医院 | Traditional Chinese medicine for treating pneumonia |
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| CN102488882A (en) * | 2011-12-28 | 2012-06-13 | 青岛绿曼生物工程有限公司 | Compound propolis composition for treating porcine respiratory disease syndrome and preparation method thereof |
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