CN101584821A - Compound polygala mixture used for relieving cough and expelling phlegm and preparation method thereof - Google Patents

Compound polygala mixture used for relieving cough and expelling phlegm and preparation method thereof Download PDF

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Publication number
CN101584821A
CN101584821A CNA2009100163671A CN200910016367A CN101584821A CN 101584821 A CN101584821 A CN 101584821A CN A2009100163671 A CNA2009100163671 A CN A2009100163671A CN 200910016367 A CN200910016367 A CN 200910016367A CN 101584821 A CN101584821 A CN 101584821A
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honey
grams
processed
polygala
mixture
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CN101584821B (en
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孙毅
黄振
程慎令
李燕
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Abstract

The invention discloses a compound polygala mixture used for relieving cough and expelling phlegm, which is prepared from the following medicinal raw materials through a preparation process: 100 milliliters of polygala tincture, 20 milliliters of almond juice, 20 milliliters of syrupus simplex, 20 grams of purified pinellia, 20 grams of honey-roasted ephedra, 20 grams of honey-roasted coltsfoot, 20 grams of honey-roasted aster, 20 grams of honey-roasted mulberry root-bark, 20 grams of fructus trichosanthis, 15 grams of stir-fried white mustard, 15 grams of figwort, 15 grams of rhizoma belamcandae, 15 grams of ginkgo nut, 15 grams of tabasheer, 15 grams of bamboo shavings, and 9 grams of licorice. The prepared mixture has the functions of relieving cough and expelling phlegm, the preparation process is simple, the mixture is convenient to take, and the cost is low. Through long-term clinical observation, the treatment effect is definite, and the toxic and side effect is small.

Description

A kind of compound polygala mixture that is used for relieving cough and expelling phlegm and preparation method thereof
Technical field
The present invention relates to a kind ofly have antitussive, the oral preparation of Chinese traditional medicinal of effect and preparation method thereof that eliminates the phlegm, relate in particular to a kind of compound polygala mixture that is used for relieving cough and expelling phlegm and preparation method thereof.
Background technology
According to national part city in 2006 and rural area top ten principal disease cause of death statistics number, respiratory system disease (not comprising pulmonary carcinoma) accounts for the 4th (13.1%) in the dead cause of disease in city, account in the rural area the 3rd (16.4%).The clinical main feature of respiratory system disease is cough, expectoration.Some disease such as bronchial asthma are because the expectoration difficulty violent cough, thick sputum often appear, in the high response of air flue.Present Chinese traditional treatment with antitussive, to eliminate the phlegm be basic principle, obtained certain curative effect clinically.Though the Chinese medicine curative effect is reliable, herbal decoction decoction trouble, technical operation requires high, is unfavorable for the long-term treatment of chronic disease.
Summary of the invention
The purpose of this invention is to provide a kind of taking convenience, the cheap compound polygala mixture of relieving cough and expelling phlegm and preparation method thereof that is used for.
For achieving the above object, the technical solution used in the present invention is:
A kind of compound polygala mixture that is used for relieving cough and expelling phlegm is characterized in that: made by preparation process by following medicine material: polygala tincture 100ml, aqua armeniacae 20ml, simple syrup 20ml, Rhizoma Pinelliae 20g, processed with honey Herba Ephedrae 20g, processed with honey Flos Farfarae 20g, Radix Asteris (processed with honey) 20g, processed with honey Cortex Mori 20g, Fructus Trichosanthis 20g, Semen Sinapis Albae (parched) 15g, Radix Scrophulariae 15g, Rhizoma Belamcandae 15g, Semen Ginkgo 15g, Concretio Silicea Bambusae 15g, Caulis Bambusae In Taenia 15g, Radix Glycyrrhizae 9g.
A kind ofly prepare the described method that is used for the compound polygala mixture of relieving cough and expelling phlegm, it is characterized in that: get one in 1000ml measuring cup, add about 300ml purified water, get one in 100ml measuring cup again, measure aqua armeniacae 20ml, simple syrup 20ml respectively and add in the above-mentioned purified water, this measuring cup of reuse is measured polygala tincture 100ml, slowly adds to go up in the liquid, with adding, get solution (I) with stirring; Use Rhizoma Pinelliae 20g, processed with honey Herba Ephedrae 20g, processed with honey Flos Farfarae 20g, Radix Asteris (processed with honey) 20g, processed with honey Cortex Mori 20g, Fructus Trichosanthis 20g, Semen Sinapis Albae (parched) 15g, Radix Scrophulariae 15g, Rhizoma Belamcandae 15g, Semen Ginkgo 15g, Concretio Silicea Bambusae 15g, Caulis Bambusae In Taenia 15g, Radix Glycyrrhizae 9g 13 flavor Chinese herbal medicine decoct with water twice, decoct 1 hour for the first time, decoct filtered while hot 40 minutes for the second time, merge twice decocting liquid and be concentrated into 200ml, leave standstill and put coldly, add in the above-mentioned solution (I), the limit edged stirs, add purified water at last to 1000ml, stir evenly, promptly.
The present invention makes the mixture with Antitussive and Expectorant Effect with polygala tincture, aqua armeniacae, simple syrup, Rhizoma Pinelliae, processed with honey Herba Ephedrae, processed with honey Flos Farfarae, Radix Asteris (processed with honey), processed with honey Cortex Mori, Fructus Trichosanthis, Semen Sinapis Albae (parched), Radix Scrophulariae, Rhizoma Belamcandae, Semen Ginkgo, Concretio Silicea Bambusae, Caulis Bambusae In Taenia, Radix Glycyrrhizae by preparation process, preparation technology is simple, taking convenience, and cheap.Long-term clinical observation, determined curative effect, toxic and side effects are little.
The specific embodiment
The invention will be further described below in conjunction with specific embodiment:
One, the present invention is made up of following medicine material:
Polygala tincture 100ml (commercially available known medicine is as the polygala tincture of the many Pharmaceuticaies of Guangzhou star limited company production), aqua armeniacae 20ml (commercially available known medicine, aqua armeniacae as the production of Fructus Pruni brightness sky, Hangzhou power Pharmaceutical limited company), simple syrup 20ml (commercially available known medicine), Rhizoma Pinelliae 20g, processed with honey Herba Ephedrae 20g, processed with honey Flos Farfarae 20g, Radix Asteris (processed with honey) 20g, processed with honey Cortex Mori 20g, Fructus Trichosanthis 20g, Semen Sinapis Albae (parched) 15g, Radix Scrophulariae 15g, Rhizoma Belamcandae 15g, Semen Ginkgo 15g, Concretio Silicea Bambusae 15g, Caulis Bambusae In Taenia 15g, Radix Glycyrrhizae 9g.
Two, preparation method of the present invention:
Get one in 1000ml measuring cup, add about 300ml purified water, get one in 100ml measuring cup again, measure aqua armeniacae 20ml, simple syrup 20ml respectively and add in the above-mentioned purified water, this measuring cup of reuse is measured polygala tincture 100ml, slowly adds to go up in the liquid, with adding, get solution (I) with stirring; Use Rhizoma Pinelliae 20g, processed with honey Herba Ephedrae 20g, processed with honey Flos Farfarae 20g, Radix Asteris (processed with honey) 20g, processed with honey Cortex Mori 20g, Fructus Trichosanthis 20g, Semen Sinapis Albae (parched) 15g, Radix Scrophulariae 15g, Rhizoma Belamcandae 15g, Semen Ginkgo 15g, Concretio Silicea Bambusae 15g, Caulis Bambusae In Taenia 15g, Radix Glycyrrhizae 9g 13 flavor Chinese herbal medicine decoct with water twice, decoct 1 hour for the first time, decoct filtered while hot 40 minutes for the second time, merge twice decocting liquid and be concentrated into 200ml, leave standstill and put coldly, add in the above-mentioned solution (I), the limit edged stirs, add purified water at last to 1000ml, stir evenly, promptly.
The purified water preparation:
1, drinking water is with water quality well water or to purify the disinfectant tap water be the water source preferably, and the drinking water of preparation purified water should meet Ministry of Public Health domestic water standard.
2, purified water is the water source with the drinking water.
3, the water puality check project of purified water and method are according to " 2005 editions the 303rd page check conformance with standard of Chinese pharmacopoeia.
4, should to keep be fresh to purified water, surpasses six hours, must not reuse.
Weighing:
According to what and the accuracy of measuring liquid, select suitable measuring device; Measuring device should keep vertically when measuring, and during reading, the minimum point of eyes and liquid concave meniscus should be on same horizontal line, and opaque liquid is got the upper surface reading; Same measuring device can only be measured with a kind of liquid, if when measuring another kind of liquid, should clean the back reuse; The liquid of having measured must not be refunded in the former container again.
The compound polygala mixture quality standard:
The quality standard draft of compound polygala mixture is with reference to " preparation codes and standards of Chinese pharmacopoeia version in 2005 are drafted formulation.
Raw material: polygala tincture, aqua armeniacae, simple syrup, Rhizoma Pinelliae, processed with honey Herba Ephedrae, processed with honey Flos Farfarae, Radix Asteris (processed with honey), processed with honey Cortex Mori, Fructus Trichosanthis, Semen Sinapis Albae (parched), Radix Scrophulariae, Rhizoma Belamcandae, Semen Ginkgo, Concretio Silicea Bambusae, Caulis Bambusae In Taenia, Radix Glycyrrhizae.
The quality standard of polygala tincture: with reference to " one one the 464th page of Chinese pharmacopoeia version in 2005.This product is the tincture of Radix Polygalae fluid extractum through being processed into.Polygala tincture is commercially available known medicine, as the polygala tincture of the many Pharmaceuticaies of Guangzhou star limited company production.
The polygala tincture character: this product is brown liquid.
The inspection of polygala tincture: amount of alcohol should be 50%~58%.(" an appendix IX of Chinese pharmacopoeia version in 2005 M).Other should meet every regulation relevant under the tincture item.(" an appendix I of Chinese pharmacopoeia version in 2005 N).
Aqua armeniacae: commercially available known medicine, as the aqua armeniacae of Fructus Pruni brightness sky, Hangzhou power Pharmaceutical limited company production.
The discriminating of Rhizoma Pinelliae is with reference to " one one the 78th page of Chinese pharmacopoeia version in 2005.
The discriminating of Herba Ephedrae is with reference to " one one the 542nd page of Chinese pharmacopoeia version in 2005.
The compound polygala mixture character: the finished product character is pale brown color liquid.
Compound polygala mixture is differentiated:
Saponin is got this product and adds low amounts of water in the polygala tincture, and mix homogeneously adds sulphuric acid and shows red.
Hydrocyanic acid in the aqua armeniacae is got inspection product hydro-oxidation potassium test solution and ferrous sulfate test solution, adds ferric chloride test solution and dilute hydrochloric acid after the jolting, generates blue precipitation.
Compound polygala mixture is checked: should meet every regulation relevant under the mixture item." an appendix I of Chinese pharmacopoeia version in 2005 J).
Compound polygala mixture microbial limit: " Chinese pharmacopoeia two ones of versions (appendix XIJ) in 2005
Except as otherwise herein provided, the antibacterial culturing temperature is 30~35 ℃ in this inspection method, and mycete, yeast cultivation temperature are 23~28 ℃, and control bacterium cultivation temperature is 35 ℃~37 ℃.
The every 1ml of bacterial population must not cross 100, and fungi count, the every 1ml of yeast count must not cross 100, must not detect escherichia coli.
The result judges: bacteria colony count, mycete (yeast) clump count, three of bacterium of control all meet regulation under this kind microbial limit item, and it is qualified to declare test sample; Wherein any one does not meet regulation under this kind item, and it is defective to declare test sample.
Bacteria colony count, mycete (yeast) clump count are measured for the first time above under this kind microbial limit item during regulation, should be from same lot number sample stochastic sampling, 3 meansigma methods reports are as a result got in retrial 2 times.
Surpass this kind microbial limit item down during regulation as dull and stereotyped grow mold (yeast) clump count of nutrient agar or the dull and stereotyped growth of Rose Bengal Sodium agar culture medium bacteria colony count, through retrial 2 times, meansigma methods is still above regulation as a result as 3 times, and it is defective to declare test sample.
When all kinds of preparations detect control bacterium or other pathogenic bacterium, be as the criterion by once detecting the result, the retrial of no longer sampling, it is defective promptly should to declare this test sample.
Function with cure mainly: the relieving cough and expelling phlegm agent is used for abundant expectoration cough.
Usage and consumption: oral.The adult: a 10ml, 3 times on the 1st, children's is cut down according to the circumstance.
Specification: 200ml/ bottle.
Storage: airtight, shady and cool dry place preserves
The packing container standard: packing container is a water white transparency, and the plastic bottle of color and luster uniformity must not have distortion and tangible scratch, no burr, sand holes, greasy dirt, bubble etc.; Wall thickness is even, and the thickness difference of antimere wall thickness must not be greater than 1/3 of specific thickness; The bacterium seizure test should meet the requirement among the YY057.
Packing container processing method: after plastic bottle is opened bottle cap, use the inside and outside flushing of fresh purified water 3 times; Plastic bottle and the bottle cap cleaned are placed on 40~50 ℃ of oven dry in the drying baker; On the plastic bottle oven dry post action platform, irradiation 30 minutes is standby down in ultraviolet.
Environment with clear out a gathering place: more than operate under the environment of 100,000 grades of air cleanings and carry out; After above operations is finished, should in time carry out and clear out a gathering place and every registration work.
The compound polygala mixture clinical efficacy:
This preparation is an antitussive, the class of eliminating the phlegm mixture.Be used for cough, abundant expectoration.Medicine material is a polygala tincture, aqua armeniacae, simple syrup, Rhizoma Pinelliae, processed with honey Herba Ephedrae, processed with honey Flos Farfarae, Radix Asteris (processed with honey), processed with honey Cortex Mori, Fructus Trichosanthis, Semen Sinapis Albae (parched), Radix Scrophulariae, Rhizoma Belamcandae, Semen Ginkgo, Concretio Silicea Bambusae, Caulis Bambusae In Taenia, Radix Glycyrrhizae.Through long-term clinical observation determined curative effect, the treatment total effective rate reaches more than 95%.Use the report that has no adverse reaction through for many years.
Diagnostic criteria upper respiratory tract infection, acute bronchitis, bronchopneumonia etc. all adopt Tao Tianzun " clinical common disease diagnosis and treatment standard ".
Include that the case standard is all to have cough, an expectoration symptom in, meet upper respiratory tract sense, acute bronchitis, bronchopneumonia diagnostic criteria, the course of disease≤6d person can be included the test case in.
Get rid of case standard (1) and turn out to be chronic cough due to the factors such as antibacterial, tuberculosis, fungus, tumor, pneumoconiosis, pulmonary abscess, bronchial asthma, bronchiectasis, heart disease, cardiac insufficiency, chronic naso-pharynageal disease, the irritative gas allergy patient that pants on inspection; (2) do not meet the patient who includes the case standard in; (3) not medication in accordance with regulations can't be judged the patient of curative effect.
1, clinical data: the present invention collects clinic case 100 examples that meet above-mentioned standard from October, 2006~2007 year October.With patient's random packet, 50 examples are organized in treatment, wherein male 22 examples, women 28 examples; The oldest 63 years old, minimum 23 years old, average 40 years old; The grading that is in a bad way belongs to moderate 30 examples, severe 20 examples.Matched group 50 examples, wherein male 22 examples, women 28 examples; The oldest 60 years old, minimum 24 years old, average 38 years old; The grading that is in a bad way belongs to moderate 32 examples, severe 18 examples.Two groups of data contrast there was no significant differences (P>0.05) have comparability.
2, Therapeutic Method
Treatment group oral administered compound polygala mixture, a 10ml, 3 times on the 1st, totally one week.25 milliliters of the oral JIZHI TANGJIANG of matched group one time, 3 times on the one, totally one week.The equal use in conjunction ceftriaxone sodium of treatment group and matched group 2.0g+NS250ml, intravenous drip, 1 time on the one, totally one week.
Curative effect determinate standard adopts the tcm syndrome scoring system, specifically drafts according to the chief editor of State Administration of Traditional Chinese Medicine " traditional Chinese medical science disease diagnosis criterion of therapeutical effect ".
Cough, expectoration, rale by light, in, heavy and heating gives 1 minute, 2 minutes, 3 minutes respectively by basic, normal, high, calculates by integration method before and after the treatment, every routine case is with following formula judgement curative effect score value:
Total score value * 100% before and after curative effect score value=(total score value before the treatment-total score value in treatment back)/treatment.Curative effect score value grade scale: reducing is clinical recovery more than 90%; 89%~60% is produce effects; 59%~30% is effective; Be invalid below 29%.Total effectively (rate)=clinical recovery+produce effects+effectively.
Observation index: observe and write down treatment front and back clinical symptoms, sign (mainly being cough, expectoration, pulmonary rale, heating).General routine examination routine blood test, sheet is taken the photograph by pulmonary in case of necessity.
Statistical method: detect The data t check.
3, result
The two groups of curative effects in treatment back compare:
Group n Clinical recovery Produce effects Effectively Invalid Total effective rate
The treatment group 50 40* 5 4 1 98%*
Matched group 50 30 5 11 4 92%
Annotate: treatment back treatment group and matched group be * P<0.05 relatively.
Efficacy analysis: clinical by total effects analysis to treatment group and matched group, learn by statistics and check, treatment back treatment group and matched group obvious effective rate there was no significant difference (P>0.05), but clinic control rate and total effective rate obviously are better than matched group (P<0.05), explanation is in the relieving cough and expelling phlegm treatment, and the compound polygala mixture curative effect is better than JIZHI TANGJIANG.
Toxicity: two groups of treatment backs check that hepatic and renal function is all no abnormal, have no adverse reaction.

Claims (2)

1, a kind of compound polygala mixture that is used for relieving cough and expelling phlegm is characterized in that: made by preparation process by following medicine material: polygala tincture 100ml, aqua armeniacae 20ml, simple syrup 20ml, Rhizoma Pinelliae 20g, processed with honey Herba Ephedrae 20g, processed with honey Flos Farfarae 20g, Radix Asteris (processed with honey) 20g, processed with honey Cortex Mori 20g, Fructus Trichosanthis 20g, Semen Sinapis Albae (parched) 15g, Radix Scrophulariae 15g, Rhizoma Belamcandae 15g, Semen Ginkgo 15g, Concretio Silicea Bambusae 15g, Caulis Bambusae In Taenia 15g, Radix Glycyrrhizae 9g.
2, a kind of described method that is used for the compound polygala mixture of relieving cough and expelling phlegm of claim 1 for preparing, it is characterized in that: get one in 1000ml measuring cup, add about 300ml purified water, get one in 100ml measuring cup again, measure aqua armeniacae 20ml, simple syrup 20ml respectively and add in the above-mentioned purified water, this measuring cup of reuse is measured polygala tincture 100ml, slowly adds to go up in the liquid, with adding, get solution (I) with stirring; Use Rhizoma Pinelliae 20g, processed with honey Herba Ephedrae 20g, processed with honey Flos Farfarae 20g, Radix Asteris (processed with honey) 20g, processed with honey Cortex Mori 20g, Fructus Trichosanthis 20g, Semen Sinapis Albae (parched) 15g, Radix Scrophulariae 15g, Rhizoma Belamcandae 15g, Semen Ginkgo 15g, Concretio Silicea Bambusae 15g, Caulis Bambusae In Taenia 15g, Radix Glycyrrhizae 9g 13 flavor Chinese herbal medicine decoct with water twice, decoct 1 hour for the first time, decoct filtered while hot 40 minutes for the second time, merge twice decocting liquid and be concentrated into 200ml, leave standstill and put coldly, add in the above-mentioned solution (I), the limit edged stirs, add purified water at last to 1000ml, stir evenly, promptly.
CN2009100163671A 2009-06-16 2009-06-16 Compound polygala mixture used for relieving cough and expelling phlegm and preparation method thereof Expired - Fee Related CN101584821B (en)

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Cited By (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103393923A (en) * 2013-08-23 2013-11-20 北京首儿药厂 Preparation method of semen armeniacae amarae and thunberg fritillary bulb oral liquid for relieving cough and resolving phlegm
CN103735909A (en) * 2014-01-17 2014-04-23 江西正邦动物保健品有限公司 Compound preparation for treating animal lung heat and preparation method thereof
CN105412858A (en) * 2015-11-19 2016-03-23 岳海棠 Syrup and preparation method thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100404060C (en) * 2005-01-25 2008-07-23 洛荣吉 Method for preparing 10-component tablets for cough

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103393923A (en) * 2013-08-23 2013-11-20 北京首儿药厂 Preparation method of semen armeniacae amarae and thunberg fritillary bulb oral liquid for relieving cough and resolving phlegm
CN103393923B (en) * 2013-08-23 2014-10-22 北京首儿药厂 Preparation method of semen armeniacae amarae and thunberg fritillary bulb oral liquid for relieving cough and resolving phlegm
CN103735909A (en) * 2014-01-17 2014-04-23 江西正邦动物保健品有限公司 Compound preparation for treating animal lung heat and preparation method thereof
CN103735909B (en) * 2014-01-17 2016-02-17 江西正邦动物保健品有限公司 A kind of compound preparation for the treatment of animal lung heat and preparation method thereof
CN105412858A (en) * 2015-11-19 2016-03-23 岳海棠 Syrup and preparation method thereof

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