CN103055047B - Pure Chinese medicinal composition for treating infectious hemorrhagic disease of grass carp and preparation method thereof - Google Patents
Pure Chinese medicinal composition for treating infectious hemorrhagic disease of grass carp and preparation method thereof Download PDFInfo
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Abstract
The invention relates to a pure Chinese medicinal composition for treating infectious hemorrhagic disease of grass carp and a preparation method thereof. The composition is prepared by mixing the following components in part by weight: 15 to 35 parts of hairyvein agrimonia herb and bud, 15 to 35 parts of callicarpa undiflora, 15 to 35 parts of isatis root, 25 to 45 parts of rhubarb, 25 to 45 parts of dried orange peel, 15 to 35 parts of lightyellow sophora root, 20 to 40 parts of Chinese pulsatilla root and 20 to 40 parts of sweet wormwood herb. The pure Chinese medicinal composition is reasonable in formula, is easy to prepare, does not have any toxic or side effect, is subjected to superfine grinding, is high in bioavailability, treats both symptoms and root causes, has a very obvious curative effect and is clinically proven to have a special effect of treating infectious hemorrhagic disease of grass carp, and medicine residue and medicine resistance are avoided.
Description
Technical field
The present invention relates to pure Chinese medicine composition for the treatment of Ctenopharyngodon idellus infectiousness hemorrhagic disease and preparation method thereof, belong to animal field of medicaments, particularly a kind of pure Chinese medicine composition that is specifically designed to treatment Ctenopharyngodon idellus infectiousness hemorrhagic disease and preparation method thereof.
Background technology
Ctenopharyngodon idellus infectiousness hemorrhagic disease is a kind of infectious disease of serious harm Ctenopharyngodon idellus, and this is a kind of popular wide, season is long, sickness rate is high, mortality rate is high a kind of disease.Production to Grass Carp Juveniles causes heavy losses.This disease pathogen is GCHV, generally in late June to early October, still has popularly, and be epidemic peak season August.This disease shows as the mottled or block hyperemia of each Organ and tissue of Ctenopharyngodon idellus inside and outside, and congested phenomenon appears in the organs such as oral cavity, the gill cover, fin base, muscle, intestinal, liver,spleen,kidney, is " red muscularity ".10～15 centimetres of above Ctenopharyngodon idellus kinds be take intestinal, fin base, the gill cover and oral cavity hyperemia as main, are " the thin gill cover type of red fin " or " intestinal type ", and in various degree hemorrhage appears in Ctenopharyngodon idellus more than an age.
Sharply, General Symptoms worsens fast the disease of primary disease, and malpractice easily causes death, causes serious economic loss to fish culture industry, and mortality rate is generally between 50%-80%.
This disease almost spreads all over the world all fish cultures country, is widely distributed.Primary disease western medical treatment is mainly used antiviral agents and antibiosis anti-inflammatory drug, though receive certain effect, because its toxic and side effects by force, easily produces the problems such as drug resistance and drug residue, clinical practice is very limited or bans use of.And therapeutic principle of traditional Chinese medicine to take heat-clearing and toxic substances removing, removing heat from blood, harmonizing yingfen and weifen be the rule for the treatment of.At present, treat the most frequently used Chinese medicine of this disease because its prescription is unreasonable or just simple pulverizing, particle diameter is excessive, and drug release is slower, causes its bioavailability lower, and clinical effectiveness is not fine.
Therefore research and develop a kind of pure Chinese prescription for the treatment of Ctenopharyngodon idellus infectiousness hemorrhagic disease, micronizing, bioavailability are high, and the specific medicament for the treatment of both the principal and secondary aspects of a disease is one of this field scientific research technical staff new problem anxious to be resolved.
Summary of the invention
The object of the invention is to overcome above-mentioned weak point, provide a kind of reasonable recipe, preparation simple, micronizing, bioavailability are high, treating both the principal and secondary aspects of a disease, pure Chinese medicine composition of effective treatment Ctenopharyngodon idellus infectiousness hemorrhagic disease of successful and preparation method thereof.
Implementation of the present invention is as follows for achieving the above object: a kind of pure Chinese medicine composition for the treatment of Ctenopharyngodon idellus infectiousness hemorrhagic disease, by following component by weight mixed preparing form: Herba Agrimoniae 15-35 part, Folium Callicarpae Formosanae 15-35 part, Radix Isatidis 15-35 part, Radix Et Rhizoma Rhei 25-45 part, Pericarpium Citri Reticulatae 25-45 part, Radix Sophorae Flavescentis 15-35 part, Radix Pulsatillae 20-40 part, Herba Artemisiae Annuae 20-40 part.
Described various component optimum ratio amount is: 25 parts of Herba Agrimoniaes, 25 parts of Folium Callicarpae Formosanae, 25 parts of Radix Isatidis, 35 parts of Radix Et Rhizoma Rhei, 35 parts of Pericarpium Citri Reticulataes, 25 parts of Radix Sophorae Flavescentiss, 30 parts of the Radix Pulsatillaes, 30 parts of Herba Artemisiae Annuaes.
Treat a preparation method for the pure Chinese medicine composition of Ctenopharyngodon idellus infectiousness hemorrhagic disease, carry out as follows:
(1) each composition in prescription is crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight Herba Agrimoniae 15-35 part, Folium Callicarpae Formosanae 15-35 part, Radix Isatidis 15-35 part, Radix Et Rhizoma Rhei 25-45 part, mix 5-10 minute to even;
(3) take by weight Pericarpium Citri Reticulatae 25-45 part, Radix Sophorae Flavescentis 15-35 part, Radix Pulsatillae 20-40 part, Herba Artemisiae Annuae 20-40 part, mix 5-10 minute to even;
(4) merge the mixture that above-mentioned (2), (3) step make, continue to mix 10-15 minute to evenly and get final product.
The medicinal property of each component is as follows:
Herba Agrimoniae: bitter, puckery, flat, GUIXIN, Liver Channel, have the function of astringing to arrest bleeding, dysentery relieving, removing toxic substances; Cure mainly have blood in stool, hematuria, haematemesis, epistaxis, dysentery, carbuncle sore tumefacting virus etc.
Folium Callicarpae Formosanae: bitter, pungent, flat, return spleen, stomach, Liver Channel, there is the function of dissipating blood stasis hemostasis, reducing swelling and alleviating pain; Cure mainly have blood in stool, hematuria, haematemesis, epistaxis, hemorrhage etc.
Radix Isatidis: bitter, cold, GUIXIN, stomach warp, have the function of heat-clearing and toxic substances removing, removing heat from blood sore-throat relieving; Cure mainly anemopyretic cold, laryngopharynx swelling and pain, aphtha of the mouth and tongue, skin ulcer general edema with yellowish skin poison etc.
Radix Et Rhizoma Rhei: bitter, cold, return large intestine, spleen, stomach, liver, pericardium channel, there is the function of purging heat and dredging bowels, removing pathogenic heat from blood and toxic substance from the body, removing mass blood stasis expelling; Cure mainly excess-heat constipation, combined symptoms, the yellow furunculosis of skin ulcer, conjunctival congestion and swelling pain, enteritis etc.
Pericarpium Citri Reticulatae: bitter, pungent, warm, return lung, spleen channel, there is the function of regulating qi-flowing for strengthening spleen, drying dampness to eliminate phlegm; Cure mainly poor appetite, stomachache, tripe is swollen, have loose bowels, productive cough due to phlegm-damp etc.
Radix Sophorae Flavescentis: bitter, cold, return liver, the heart, stomach, large intestine, urinary bladder channel, have that heat clearing and damp drying, parasite killing go to amass, the function of diuretic; Cure mainly damp-heat dysentery etc.
The Radix Pulsatillae: bitter, cold, return stomach, large intestine channel, there is the function of heat-clearing and toxic substances removing, eliminating pathogenic heat from blood to cure dysentery; Cure mainly toxic-heat and blood stasis, damp and hot intestinal Huang etc.
Herba Artemisiae Annuae: bitter, acrid, cold, return liver, gallbladder meridian, there is the function of heat-clearing and toxic substances removing, protozoacide; Cure mainly coccidiosis, jaundice due to damp-heat etc.
All herbal medicines, according to the theoretical compatible combination of Chinese veterinarian, for paathogenic factor and the clinical symptoms of Ctenopharyngodon idellus infectiousness hemorrhagic disease, are brought into play the effect for the treatment of both the principal and secondary aspects of a disease above.
The invention has the beneficial effects as follows: reasonable recipe, preparation is simple, and substep mixes more even; Pure Chinese medicine composition, treating both the principal and secondary aspects of a disease, cost is low, draws materials wide, and micronizing, bioavailability are high, curative effect highly significant.The present invention is theoretical according to Chinese veterinarian, optimizes this eight herbal medicine, and they are formed according to optimum ratio, and clinical practice proves that treatment Ctenopharyngodon idellus infectiousness hemorrhagic disease is had to specially good effect.
The specific embodiment
Below in conjunction with preferred embodiment, to according to the specific embodiment provided by the invention, details are as follows:
Embodiment 1
A kind of pure Chinese medicine composition for the treatment of Ctenopharyngodon idellus infectiousness hemorrhagic disease and preparation method thereof: carry out as follows: (every part by 10g)
(1) each composition in prescription is crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight 150 parts of Herba Agrimoniaes, 150 parts of Folium Callicarpae Formosanae, 150 parts of Radix Isatidis, 250 parts of Radix Et Rhizoma Rhei, mix 5-10 minute to even;
(3) take by weight 250 parts of Pericarpium Citri Reticulataes, 150 parts of Radix Sophorae Flavescentiss, 200 parts of the Radix Pulsatillaes, 200 parts of Herba Artemisiae Annuaes, mix 5-10 minute to even;
(4) merge the mixture that above-mentioned (2), (3) step make, continue to mix 10-15 minute to evenly and get final product.
Embodiment 2
A kind of pure Chinese medicine composition for the treatment of Ctenopharyngodon idellus infectiousness hemorrhagic disease and preparation method thereof: carry out as follows: (every part by 10g)
(1) each composition in prescription is crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight 250 parts of Herba Agrimoniaes, 250 parts of Folium Callicarpae Formosanae, 250 parts of Radix Isatidis, 350 parts of Radix Et Rhizoma Rhei, mix 5-10 minute to even;
(3) take by weight 350 parts of Pericarpium Citri Reticulataes, 250 parts of Radix Sophorae Flavescentiss, 300 parts of the Radix Pulsatillaes, 300 parts of Herba Artemisiae Annuaes, mix 5-10 minute to even;
(4) merge the mixture that above-mentioned (2), (3) step make, continue to mix 10-15 minute to evenly and get final product.
Embodiment 3
A kind of pure Chinese medicine Chinese medicine composition for the treatment of Ctenopharyngodon idellus infectiousness hemorrhagic disease and preparation method thereof: carry out as follows: (every part by 10g)
(1) each composition in prescription is crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight 350 parts of Herba Agrimoniaes, 350 parts of Folium Callicarpae Formosanae, 350 parts of Radix Isatidis, 450 parts of Radix Et Rhizoma Rhei, mix 5-10 minute to even;
(3) take by weight 450 parts of Pericarpium Citri Reticulataes, 350 parts of Radix Sophorae Flavescentiss, 400 parts of the Radix Pulsatillaes, 400 parts of Herba Artemisiae Annuaes, mix 5-10 minute to even;
(4) merge the mixture that above-mentioned (2), (3) step make, continue to mix 10-15 minute to evenly and get final product.
Clinical trial:
Clinical experiment animal selects 150 ages in days, body weight at 1.0kg-1.5kg, and Laboratory Diagnosed is the ill fish of Ctenopharyngodon idellus infectiousness hemorrhagic disease.Ill Ctenopharyngodon idellus isolation is raised separately, the complete feed of feeding, and be divided at random 3 groups, and every group of 30 tails, 3 groups of feeding environments are identical, and experiment is carried out 5 days altogether; Blank group is left intact, and medicine matched group is used treatment with " fish is precious loose " by specification; Present composition group can be for oral administration by product of the present invention (the prepared compositions of the embodiment of the present invention 1), in 2.5% ratio, admixes bait feeding, every day 2-3 time, is used in conjunction 3-5 days; After oral, by gastrointestinal absorption, reach the object for the treatment of disease.Computational methods: mortality rate=dead animal number/experimental animal number * 100%, cure rate=healing number of animals/experimental animal number * 100%.Result (testing the 5th day) when following table is experiment end.
Table is the field applicable cases contrast of the present invention and other medicines treatment Ctenopharyngodon idellus infectiousness hemorrhagic disease:
| Numbering | Group | Mortality rate % | Cure rate % | During end, there is symptom rate % |
| I | Blank group | 53.3 | 30.0 | 16.7 |
| II | The precious loose group of fish | 13.3 | 73.4 | 13.3 |
| III | Present composition group | 3.3 | 86.7 | 10.0 |
This clinical effectiveness statistical analysis, present composition treatment group is being compared difference extremely significantly (P < 0.01) with the precious loose group of fish aspect cure rate.
Safety testing:
Choose 80 age in days healthy grass carp 30 tails, 5 times according to the made compositions recommended dose of the embodiment of the present invention 1 take orally 10 days, during medication, there is not any bad or Deviant Behavior performance in healthy grass carp, the drinking-water of searching for food is normal, and body weight increases that to compare difference not remarkable with blank group (being not administration of health group).
Above-mentioned detailed description of pure Chinese medicine composition of this treatment Ctenopharyngodon idellus infectiousness hemorrhagic disease and preparation method thereof being carried out with reference to embodiment; illustrative rather than determinate; can list several embodiment according to institute's limited range; therefore in the variation and the modification that do not depart under general plotting of the present invention, within should belonging to protection scope of the present invention.
Claims (3)
1. treat a pure Chinese medicine composition for Ctenopharyngodon idellus infectiousness hemorrhagic disease, it is characterized in that by following component by weight mixed preparing form: Herba Agrimoniae 15-35 part, Folium Callicarpae Formosanae 15-35 part, Radix Isatidis 15-35 part, Radix Et Rhizoma Rhei 25-45 part, Pericarpium Citri Reticulatae 25-45 part, Radix Sophorae Flavescentis 15-35 part, Radix Pulsatillae 20-40 part, Herba Artemisiae Annuae 20-40 part.
2. the pure Chinese medicine composition for the treatment of Ctenopharyngodon idellus infectiousness hemorrhagic disease according to claim 1, it is characterized in that by following component by weight mixed preparing form: 25 parts of Herba Agrimoniaes, 25 parts of Folium Callicarpae Formosanae, 25 parts of Radix Isatidis, 35 parts of Radix Et Rhizoma Rhei, 35 parts of Pericarpium Citri Reticulataes, 25 parts of Radix Sophorae Flavescentiss, 30 parts of the Radix Pulsatillaes, 30 parts of Herba Artemisiae Annuaes.
3. a preparation method for the pure Chinese medicine composition for the treatment of Ctenopharyngodon idellus infectiousness hemorrhagic disease according to claim 1, is characterized in that carrying out as follows:
(1) each composition in prescription is crossed to 700 mesh sieves after micronizing respectively;
(2) take by weight Herba Agrimoniae 15-35 part, Folium Callicarpae Formosanae 15-35 part, Radix Isatidis 15-35 part, Radix Et Rhizoma Rhei 25-45 part, mix 5-10 minute to even;
(3) take by weight Pericarpium Citri Reticulatae 25-45 part, Radix Sophorae Flavescentis 15-35 part, Radix Pulsatillae 20-40 part, Herba Artemisiae Annuae 20-40 part, mix 5-10 minute to even;
(4) merge the mixture that above-mentioned (2), (3) step make, continue to mix 10-15 minute to evenly and get final product.
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| CN103655855B (en) * | 2012-09-24 | 2015-10-14 | 天津瑞贝特科技发展有限公司 | Chinese medicine composition for the treatment of research of hemorrhage of grass carp and preparation method thereof |
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| CN1903280A (en) * | 2006-07-28 | 2007-01-31 | 河南农业大学 | Yukangsan herb medicine powder for treating fish diseases |
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| CN101961391A (en) * | 2010-06-23 | 2011-02-02 | 天津生机集团股份有限公司 | Traditional Chinese medicine composition for preventing and controlling grass carp disease |
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| CN102068542A (en) * | 2009-11-20 | 2011-05-25 | 戚冬梅 | Medicament for treating hemorrhage disease of grass carp |
| CN102100788A (en) * | 2009-12-16 | 2011-06-22 | 青岛康地恩药业有限公司 | Chinese medicinal preparation for preventing and treating chicken coccidiosis |
| CN102526318A (en) * | 2011-12-09 | 2012-07-04 | 射洪郑葛生态养殖有限责任公司 | Chinese medicinal composition for preventing and treating chicken diseases and preparation method thereof |
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Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1903280A (en) * | 2006-07-28 | 2007-01-31 | 河南农业大学 | Yukangsan herb medicine powder for treating fish diseases |
| CN101269218A (en) * | 2008-04-23 | 2008-09-24 | 安徽省农业科学院水产研究所 | Fortifier, special bait, injection for bleeding disease immunity of Chinese idle and novel immunity method |
| CN102068542A (en) * | 2009-11-20 | 2011-05-25 | 戚冬梅 | Medicament for treating hemorrhage disease of grass carp |
| CN102100788A (en) * | 2009-12-16 | 2011-06-22 | 青岛康地恩药业有限公司 | Chinese medicinal preparation for preventing and treating chicken coccidiosis |
| CN101961391A (en) * | 2010-06-23 | 2011-02-02 | 天津生机集团股份有限公司 | Traditional Chinese medicine composition for preventing and controlling grass carp disease |
| CN102028816A (en) * | 2010-11-24 | 2011-04-27 | 清远海贝生物技术有限公司 | Chinese herbal medicinal compound preparation for treating hemorrhage disease of grass carp |
| CN102526318A (en) * | 2011-12-09 | 2012-07-04 | 射洪郑葛生态养殖有限责任公司 | Chinese medicinal composition for preventing and treating chicken diseases and preparation method thereof |
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