CN106620066A - Traditional Chinese medicine composition for promoting estrus and pregnancy of animals and preparation method thereof - Google Patents
Traditional Chinese medicine composition for promoting estrus and pregnancy of animals and preparation method thereof Download PDFInfo
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
- A61K36/284—Atractylodes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/34—Campanulaceae (Bellflower family)
- A61K36/344—Codonopsis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/46—Eucommiaceae (Eucommia family), e.g. hardy rubber tree
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/481—Astragalus (milkvetch)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/48—Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
- A61K36/488—Pueraria (kudzu)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/533—Leonurus (motherwort)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/62—Nymphaeaceae (Water-lily family)
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/30—Extraction of the material
- A61K2236/33—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones
- A61K2236/331—Extraction of the material involving extraction with hydrophilic solvents, e.g. lower alcohols, esters or ketones using water, e.g. cold water, infusion, tea, steam distillation, decoction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2236/00—Isolation or extraction methods of medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicine
- A61K2236/50—Methods involving additional extraction steps
- A61K2236/51—Concentration or drying of the extract, e.g. Lyophilisation, freeze-drying or spray-drying
Abstract
The invention discloses a traditional Chinese medicine composition for promoting estrus and pregnancy of animals and a preparation method thereof. The traditional Chinese medicine composition is prepared from the following traditional Chinese medicinal materials in parts by weight: 15-25 parts of curculigo orchioides, 10-20 parts of eucommia ulmoides, 10-20 parts of flatstem milkvetch seeds, 5-15 parts of lotus stamen, 5-15 parts of herba leonuri, 5-15 parts of campsis grandiflora, 5-15 parts of codonopsis pilosula, 1-10 parts of rhizoma atractylodis macrocephalae and 1-10 parts of radix pueraiae.
Description
Technical field
The present invention relates to technical field of traditional Chinese medicines, and in particular to a kind of Chinese medicine composition for progestogenic of promoting the sexual maturity and preparation method thereof.
Background technology
At present the scale of animal farming industry is increasing, walks industrialized development, marketing development road.But, due to outer
Not enough, the impact of artificial manufacture climatic environment, standby jenny rate out of heat is up to 40%, Jing and produces female for the stimulation of portion's factor
Animal also has 15-20%, for the enterprise for producing according to plan, has both improved production cost, unnecessary work is increased again strong
Degree.For this problem, prior art is promoted the sexual maturity using the chemistry injection such as intramuscular injection pregnant mare serum, cloprostenol, although can make it
Heat, but return feelings rate and nonpregnant rate is up to more than 50%, and farrowing rate is low, and abortion rate is high, and does not utilize the growth of the young
Development.Chinese veterinarian has obvious advantage using treatment by Chinese herbs, can avoid above drawback, but there is also some problems needing improvement badly
Improve, curative effect is unstable, prescription is huge, inconvenience etc. is administered.
The present invention provides a kind of Chinese medicine composition for progestogenic of promoting the sexual maturity for domestic animal and preparation method thereof, Jing clinical testing tables
Bright, its effect of promoting the sexual maturity is good, for this present invention provides one kind by thizoma curculiginis, the bark of eucommia, semen astragali complanati, stamen nelumbini, motherwort, Chinese trumpet creeper, Radix Codonopsis,
The Chinese medicine that the bighead atractylodes rhizome, the root of kudzu vine are prepared from, with promoting blood circulation for regulating menstruation, filling liver kidney, it is antiabortive based on, with progestogenic of promoting the sexual maturity, improve livestock reproduction
The effect of ability.
The content of the invention
The invention discloses a kind of Chinese medicine composition of progestogenic of promoting the sexual maturity for domestic animal, by the Chinese medicine material of following weight proportion
Medicine is prepared from：15～25 parts of thizoma curculiginis, 10～20 parts of the bark of eucommia, 10～20 parts of semen astragali complanati, 5～15 parts of stamen nelumbini, motherwort 5～15
Part, 5～15 parts of Chinese trumpet creeper, 5～15 parts of Radix Codonopsis, 1～10 part of the bighead atractylodes rhizome, 1～10 part of the root of kudzu vine.
Preferably, it is prepared from by the Chinese medicine material medicine of following weight proportion：18～22 parts of thizoma curculiginis, 13～18 parts of the bark of eucommia,
8～12 parts of semen astragali complanati, 8～12 parts of stamen nelumbini, 8～12 parts of motherwort, 8～12 parts of Chinese trumpet creeper, 2～8 parts of Radix Codonopsis, 2～8 parts of the bighead atractylodes rhizome,
2～8 parts of the root of kudzu vine.
It is furthermore preferred that being prepared from by the Chinese medicine material medicine of following weight proportion：
20 parts of thizoma curculiginis, 15 parts of the bark of eucommia, 15 parts of semen astragali complanati, 10 parts of stamen nelumbini, 10 parts of motherwort, 10 parts of Chinese trumpet creeper, 10 parts of Radix Codonopsis,
5 parts of the bighead atractylodes rhizome, 5 parts of the root of kudzu vine.
Preferably, it is described preventing and treating domestic animal promote the sexual maturity progestogenic herbal mixture be tablet, capsule, granule, pill, paste,
Solution, injection, suppository, spray, drops or patch.
Second aspect present invention provide it is a kind of for domestic animal promote the sexual maturity progestogenic herbal mixture preparation method.Specifically,
The method comprising the steps of：
First, thizoma curculiginis, the bark of eucommia, semen astragali complanati, stamen nelumbini, motherwort, Chinese trumpet creeper, Radix Codonopsis, the bighead atractylodes rhizome and the root of kudzu vine are placed in decoction vessel,
Add water to cook and obtain decoction liquor；
2nd, the decoction liquor in step one is filtered, stands 8～12h, take supernatant, under the conditions of 50 DEG C phase is evaporated to
It is 1.21～1.27 to density, drying makes dry cream；
3rd, after the dry cream in step 2 is pulverized and sieved, add dextrin to mix, that is, be obtained and promoted the sexual maturity progestogenic for domestic animal
Herbal mixture.
Preferably, the water in the step one is distilled water or deionized water.
Preferably, the method for decocting in the step one is the water for adding 8～20 times of quality of medicinal material, boils 2～3 times, often
It is secondary to boil 2～4h；Rear separating filtrate filter residue is boiled every time, adds the water of 10 times of quality of medicinal material to be boiled next time in filter residue
Boiling.
Preferably, the time for decocting in the step one is 2h.
Preferably, the aperture sieved in the step 3 is 100 mesh.
Third aspect present invention provide it is a kind of for domestic animal promote the sexual maturity progestogenic herbal mixture application.Specifically, it is described
Promote the sexual maturity for domestic animal the herbal mixture of progestogenic, for treating the symptoms such as domestic animal insufficiency of vital energy and blood, out of heat long or post-partum estrus be slow.
The invention has the advantages that：
1st, the present invention is with thizoma curculiginis, the bark of eucommia, semen astragali complanati, stamen nelumbini, motherwort, Chinese trumpet creeper, Radix Codonopsis, the bighead atractylodes rhizome and the root of kudzu vine as former material
Material, is made using modern advanced medical pharmaceutical technology, is easy to obtain with material, and preparation method is simple, low cost, is easy to big
The characteristics of large-scale production.
2nd, the present invention promotes the sexual maturity the cooperation prescription that the herbal mixture of progestogenic assisted a ruler in governing a country with the monarch and his subjects for domestic animal, and each medicine is played altogether, with work
It is blood menstruation regulating, filling liver kidney, antiabortive, reach the effect of progestogenic of promoting the sexual maturity.
3rd, the herbal mixture of progestogenic of promoting the sexual maturity for domestic animal of the invention, effectively raises the Oestrus rate of domestic animal, shortens product
Inter oestrual period afterwards, it is adaptable to treat sow and the insufficiency of vital energy and blood of cattle and sheep, long out of heat or post-partum estrus it is slow.
Chinese herbal medicine selected by the present invention, wherein, thizoma curculiginis is monarch drug in a prescription, and the bark of eucommia, semen astragali complanati are ministerial drug, stamen nelumbini, motherwort, icepro
Clouds flower, Radix Codonopsis, the bighead atractylodes rhizome are adjutant, and the root of kudzu vine is to make medicine.The property of medicine and pharmacology of ingredients is respectively：
Thizoma curculiginis：It is pungent, heat；It is poisonous.Return kidney,liver,spleen Jing.Kidney-replenishing, strengthening the bones and muscles, dispellieg cold and dampness.For impotence cold sperm, muscles and bones impotence
It is soft, waist and knee crymodynia, the deficiency of yang is cold to rush down.《Detailed outline》：Thizoma curculiginis, property heat.Mend the three burnt, medicines of the gate of vitality.Only positive weak essence is cold, the timid person of natural endowment element
Preferably it.If the strong phase heated Sheng person of body, what is taken instead can get angry.《Herbal justice》：Thizoma curculiginis is the special medicine of yang-tonifying warm kidney, also simultaneous to dispel
Arthritis, it is similar with BAZAITIAN, HERBA EPIMEDII.《Japan hanako materia medica》：All general mood are controlled, general debility, appetizer under the gas is mended.《The southern regions of the Yunnan Province sheet
Grass》：Control that married woman is red to collapse lower blood, attack ulcer, apocenosis.
The bark of eucommia：For the dry bark of Eucommiaceae plant bark of eucommia Eucommia ulmoides Oliv..It is sweet, temperature.Return liver,
Kidney channel.Filling liver kidney, strengthening the bones and muscles is antiabortive.For kidney deficiency and liver, soreness of waist and knee joint, muscles and bones is powerless, has a dizzy spell, blood leaking in gestation, movement of the foetus
It is uneasy.《Sheng Nong's herbal classic》：Main pain along spinal column, bowl spares benefit vital essence, hard muscles and bones, Qiang Zhi, except wet, dribbling urination of itching under the moon.《Name doctor is other
Record》：Ache in main pin, be not intended to trample ground.《Haigoushen》：The cold stern pain in the back of kidney is controlled, waist patient is empty and body is tetanic, wind.Waist is unfavorable to be added
And use it.《Japan hanako materia medica》：Control kidney labor, spinal column contraction.It is used as medicine and processs use.《Compendium of Materia Medica》：Bark of eucommia color is purple and moisten, sweet micro-pungent,
Its temperature put down, sweet temperature can be mended, and micro-pungent can moisten, thus energy enter liver and kidney tonifying.
Semen astragali complanati：It is sweet, temperature.Return liver and kidney channel.Tonify the kidney and support yang, astringent sperm contracting urine nourishes the liver to improve visual acuity.For lumbago due to the kidney deficiency, seminal emission is early
Let out, enuresis frequent micturition, gonorrhoea under band, dizziness, mesh is secretly dim-sighted.《Detailed outline》：" kidney tonifying, controls pain in the back and lets out essence, deficient tired.”《Book on Chinese herbal medicine from
Newly》：" kidney tonifying, Qiang Yin, benefit essence, improving eyesight.Control under band, anal fistula, cloudy Huang.Performance controlling nocturnal emission with astringent drugs.”《Medical center bun will》：" hard kidney water, rushes down heresy
It is wet, go abdominal mass hemorrhoid complicated by anal fistula.”《Mirror can about be cured》：" drip is only lost, hematuria reduces just.”
Stamen nelumbini：It is sweet, puckery, put down.The thoughts of returning home, kidney channel.Reinforcing the kidney and controlling noctural emission.For emission and spermatorrhea, under band, frequent micturition.《This Jing meets original》：
" stamen nelumbini, clear away heart-fire logical kidney, with its puckery, therefore for the key medicine of secret puckery vital essence.《Three because》Gu true ball, dipsaci,fructus ball use it, so only it is intended to diligent
Very thin person is advisable, and high sun person not processed do not use, and probably its pocket is puckery to suffer from." " stamen nelumbini, Gan Wen and it is puckery, work(is slightly same with lotus seeds.But adstringency
It is in the majority, do not tremble with fear like keel puckery, have and receive the moon, determine the wonderful of soul peace soul；Oyster is salty and bitter to be slightly cold, the hard antipyretic work(of having concurrently；Golden cherry has on foot
The puckery power of resistance, and without the reason ear of the logical kidney that clears away heart-fire.”
Motherwort：It is bitter, pungent, it is slightly cold.Return liver, pericardium, bladder warp.Promoting blood circulation for regulating menstruation, inducing diuresis to remove edema is clearing heat and detoxicating.For the moon
Jing is uncomfortable, dysmenorrhoea Amenorrhea, lochiorrhagia, oedema oliguria, sore swollen toxin.《Book on Chinese herbal medicine asks former》：Heat-clearing, cool blood, removing toxic substances.《Detailed outline》：
Promoting blood circulation, blood-breaking, menstruation regulating, removing toxic substances.Control threatened abortion and produce difficult, retention of afterbirth, bruise, blood wind, blood pain, metrorrhagia and metrostaxis, hematuria rushes down blood, dysentery,
Infantile malnutrition due to digestive disturbances or intestinalparasites, haemorrhoids is beaten and flutters interior damage hemostasis, stool, urinary obstruction.
Chinese trumpet creeper：Sweet, acid, trembles with fear.Return liver, pericardium channel.Invigorate blood circulation, cooling blood, expelling wind.For irregular menstruation, Jing Bi Disorder lumps in the abdomen,
Postpartum breast is swollen, and rubella is rubescent, pruitus, acne.《Detailed outline》:Ling Leihua and root, sweet acid and tremble with fear, cauline leaf band is bitter, promoting circulation of blood point, energy
Go the blood second of the three ten-day periods of the hot season fiery, therefore the card of all diseases of main product breast uterine bleeding and blood hot air wind producing.《This Jing meets original》:Chinese trumpet creeper, metopodynia blood is closed, vim and vigour thorn
Bitterly, strict wind dislike sore it is multiplex it, all take the work(of its dispelling malignant blood.《Legendary god of farming's book on Chinese herbal medicine》：" disease, metrorrhagia, abdominal mass, blood more than housewife people's galactopoiesis
Close, fever and chills are thin thin.”《The southern regions of the Yunnan Province book on Chinese herbal medicine》：" pruitus of dispelling, the wind that disappears is antipyretic.”
Radix Codonopsis：It is sweet, put down.Returns spleen, lung channel.There are tonifying middle-Jiao and Qi, effect of strengthening spleen and tonifying lung nourishes blood and promotes the production of body fluid.Indication：Spleen
Stomach is weak, and few food diarrhoea, deficiency syndrome of the lung cough and asthma, body is tired powerless, and the deficiency of vital energy is hung down de-.For spleen-lung Qi deficiency, eat less and tired, false asthma cough, gas
Blood is not enough, sallow complexion, palpitation, injury thirst, Heat Diabetes.Modern medicine study shows that Radix Codonopsis has regulation blood sugar,
Promote hematopoietic function, step-down, anti anoxia, endurance to strengthen immunity of organisms, adjust various effects such as stomach contraction and antiulcer.
《This Jing meets original》：Clearing lung-heat.《The new compilation of materia medica》：Tonifying middle-Jiao and Qi, and taste, relieving thirst and restlessness.《Detailed outline is picked up any lost article from the road》：Control the deficiency syndrome of the lung, beneficial lung qi.
《The medicinal herbs among the people of science》：Hematinic.Suitable for chronic anaemia, chlorosis, leukaemia, adenopathy, rickets.《Chinese medicine hand
Volume》：Consumptive disease internal injury is controlled, intestines cold in the stomach, cunning rushes down protracted dysentery, polydipsia of panting, generate heat spontaneous perspiration, and metrorrhagia, tire produce all diseases.
The bighead atractylodes rhizome:Sweet warm in nature and simultaneous bitter dry property, sweet temperature gas supplementing, bitter dry invigorating the spleen, returns spleen, stomach.Indication：Invigorating the spleen benefit
Gas, eliminate dampness and have diuretic effect, hidroschesis is antiabortive.For spleen eating less, abdominal distention diarrhea, phlegm retention anti-dazzle nervous, oedema, spontaneous perspiration, fetal irritability.It is native white
Art invigorating the spleen, and stomach, it is antiabortive.For spleen eating less, loose stool of having loose bowels, fetal irritability.Modern pharmacological research finds that the bighead atractylodes rhizome can suppress not
The contraction of the Spontaneous Contraction of pregnant mouse isolated uterine and the uteri excitation that oxytocins, motherwort are caused, and with administration agent
The increase of amount and inhibitory action strengthens.《Sheng Nong's herbal classic》：Art, bitter temperature.The dead flesh of main wind-cold-dampness arthralgia, convulsion subcutaneous ulcer, hidroschesis, heat extraction,
Help digestion, make to decoct bait.Long term usage is made light of one's life by commiting suicide macrobiosis, not hungry.《Sheng Nong's herbal classic》：Art, bitter temperature.The dead flesh of main wind-cold-dampness arthralgia, convulsion subcutaneous ulcer, only
Sweat, heat extraction helps digestion, and makees to decoct bait.Long term usage is made light of one's life by commiting suicide macrobiosis, not hungry.
The root of kudzu vine:For the dry root of legume pueraria lobata, practise and claim elegant jessamine.Autumn, the excavation of season in winter two, take advantage of fresh-cut into sheet or little
Block；It is dried.It is sweet, pungent, it is cool.There is expelling pathogenic factors from muscles and skin to bring down a fever, promoting eruption promotes the production of body fluid to quench thirst, the work(of Shengyang Zhixie.It is usually used in table card heating, rigid neck and back
Bitterly, measles without adequate eruption, pyreticosis is thirsty, and the deficiency of Yin is quenched one's thirst, and heat is purged heat dysentery, splenasthenic diarrhea.《Compendium of Materia Medica》：" root of kudzu vine is Yangming Channel medicine, and
Enter the spleen channel, spleen governing muscles.”《Bencao Jingshu》：" root of kudzu vine, dismisses the main medicine of positive bright warm disease heat evil, therefore master quenches one's thirst, high fever of the body, heat
Stop up chest diaphragm to vomit.Dissipate and rise, the property of expelling wind drug, therefore all numbness of master.”《This Jing》：Quench one's thirst, high fever of the body, vomiting, all numbness plays the moon
Gas, solves all poison.《Do not record》：Cure the wound it is cold in wind headache, expelling pathogenic factors from muscles and skin delivers perspirations, and loosing the interspaces of skin and muscles treats metal-inflicted wound, only coerces wind bitterly.
The compound Chinese medicinal preparation of the present invention, when pharmaceutical preparation is prepared into, can add if necessary pharmaceutically acceptable carrier,
It is prepared by the routine techniques according to galenic pharmacy.Chinese medicine part therein can be prepared using Chinese medicine material medicine, it is also possible to be passed through
The common Chinese medicine material that extracts is obtained, it is also possible to obtained by other means, such as：By crushing, squeezing, calcine, grind, sieve,
Diacolation, extraction, water extraction, alcohol extracting, method obtains active Chinese drug component material, these active Chinese drug component materials such as ester is carried, ketone is carried, chromatographed can be with
The material of medicinal extract form, can be dry extract can also be liquid extract, according to preparation it is different need to determine to make it is different
Concentration.
The pharmaceutical dosage forms of the present invention, are present in a unit, and the unit dosage form refers to the list of preparation
Position, such as tablet per piece, every capsule of capsule, per bag of granule etc..
The Chinese medicine preparation of the present invention can be any pharmaceutically useful formulation, and these formulations include：Tablet, capsule, particle
Agent, pill, powder, paste, sublimed preparation, pulvis, injection, suppository, spray, drops, patch.The preparation of the present invention, preferably
It is peroral dosage form, such as：Capsule, tablet, oral liquid, granule, pill, powder, sublimed preparation, paste etc..
The compound Chinese medicinal preparation of the present invention, the preparation that it is administered orally can contain conventional excipient, such as adhesive, fill out
Fill agent, diluent, tablet agent, lubricant, disintegrant, colouring agent, flavor enhancement and wetting agent.Applicable filler include starch,
Sucrose, cellulose, mannitol, the lactose filler similar with other.Suitable disintegrant includes starch, polyvinylpyrrolidine
Ketone and starch derivatives, such as sodium starch glycollate.Suitable lubricant includes, such as magnesium stearate.Can be filled out by mixing
Fill, the conventional method such as compressing tablet prepares solid oral composition.Being mixed repeatedly is distributed in can active material entirely to use
In those compositions of a large amount of fillers；Conventional adjunct ingredient includes：Mannitol, sorbierite, sodium pyrosulfite, bisulfite
Sodium, sodium thiosulfate, cysteine hydrochloride, TGA, methionine, injection Vitamin B_6 DTA disodiums, Ethylenediaminetetraacetic Acid Calcium Salt, monoacidic base gold
The carbonate of category, acetate, phosphate or its aqueous solution, hydrochloric acid, acetic acid, sulfuric acid, phosphoric acid, amino acid, sodium chloride, potassium chloride,
Sodium lactate, xylitol, maltose, glucose, fructose, dextran, glycine, starch, sucrose, lactose, mannitol, silicon spread out
Biology, cellulose and its derivates, alginates, gelatin, polyvinylpyrrolidone, glycerine, POLYSORBATE 80, agar, calcium carbonate, carbonic acid
Hydrogen calcium, surfactant, polyethylene glycol, cyclodextrin, beta-schardinger dextrin, phospholipid material, kaolin, talcum powder, calcium stearate,
Magnesium stearate etc..
Compound Chinese medicinal preparation, wherein active ingredient of Chinese herbs be 0.1%-99.9%, excipients be 0.1%- and
99.9%.
The preparation of the present invention according to circumstances determines when in use usage and dosage, can be daily 2～3 times with batch mixing, every time by every
Ton feed adds 1%～5% dosage.
The present invention further provides the preparation method of the compound Chinese medicinal preparation of the present invention：
Material of getting it filled plus 10～and 20 times of amount decoctings boil three times, 1～3 hour every time, merge decoction liquor, and filtration, liquid merges, subtracts
Pressure is concentrated into relative density 1.21～1.27 (50 DEG C), is dried to dry cream.Dry cream is ground into fine powder, adds auxiliary materials and mixing, makes
Particle packing is obtained final product.
Beneficial effects of the present invention are further illustrated below by way of experimental data.
Embodiment 1
20 parts of thizoma curculiginis, 15 parts of the bark of eucommia, 15 parts of semen astragali complanati, 10 parts of stamen nelumbini, 10 parts of motherwort, 10 parts of Chinese trumpet creeper, 10 parts of Radix Codonopsis,
5 parts of the bighead atractylodes rhizome, 5 parts of the root of kudzu vine.
Preparation process is as follows：20 parts of thizoma curculiginis, 15 parts of the bark of eucommia, 15 parts of semen astragali complanati, 10 parts of stamen nelumbini, 10 parts of motherwort, Chinese trumpet creeper
10 parts, 10 parts of Radix Codonopsis, 5 parts of the bighead atractylodes rhizome, 5 parts of the root of kudzu vine medicinal material of grade 9 adds 10～and 20 times of amount decoctings boil three times, 1～3 hour every time, close
And decoction liquor, filtration, stand overnight, leaching supernatant, it is evaporated to relative density 1.21～1.27 (50 DEG C), is dried to do
Cream.Dry cream crushed 100 mesh sieves, plus appropriate dextrin is mixed, and obtains final product powder.
Embodiment 2
20 parts of thizoma curculiginis, 15 parts of the bark of eucommia, 15 parts of semen astragali complanati, 10 parts of stamen nelumbini, 10 parts of motherwort, 10 parts of Chinese trumpet creeper, 10 parts of Radix Codonopsis,
5 parts of the bighead atractylodes rhizome, 5 parts of the root of kudzu vine.
Preparation process is as follows：Respectively take 15 parts of the bark of eucommia, 15 parts of semen astragali complanati, 10 parts of stamen nelumbini, 10 parts of Chinese trumpet creeper, 10 parts of Radix Codonopsis, white
The taste medicinal material of 5 parts of grades of art 6, plus 10～20 times of amount water, distills 2～8 hours, extracts volatile oil, and the another device of volatile oil is collected, volatile oil with
Beta-schardinger dextrin is with 1：10 inclusions, it is standby；The dregs of a decoction after extraction, with 20 parts of thizoma curculiginis, 10 parts of motherwort, 5 parts of the root of kudzu vine, plus 10～20 times
Amount decocting is boiled 1～3 time, 1～3 hour every time, merges decoction liquor, is filtered, and is evaporated to relative density 1.15～1.27 (50
DEG C), dry, pulverize, 100 mesh sieves are crossed, dried cream powder mixes with volatile oil beta cyclodextrin inclusion complex, adds appropriate dextrin to mix, i.e.,
Obtain powder.
Embodiment 3
20 parts of thizoma curculiginis, 15 parts of the bark of eucommia, 15 parts of semen astragali complanati, 10 parts of stamen nelumbini, 10 parts of motherwort, 10 parts of Chinese trumpet creeper, 10 parts of Radix Codonopsis,
5 parts of the bighead atractylodes rhizome, 5 parts of the root of kudzu vine.
Preparation process is as follows：1) by 15 parts of the bark of eucommia, 15 parts of semen astragali complanati, 10 parts of stamen nelumbini, 10 parts of Chinese trumpet creeper, 10 parts of Radix Codonopsis, white
5 parts of art is crushed respectively, mixed, and in putting volatile oil extractor, is soaked 2～3 hours, and the amount for adding water is the 10 of medicinal material gross weight
More than～20 times.More than boiling reflux 6h fully extracts volatile oil, standby, the another device storage of liquid；2) volatile oil is extracted in 1)
The dregs of a decoction afterwards, mix with 20 parts of thizoma curculiginis, 10 parts of motherwort, 5 parts of the root of kudzu vine, add water to cook 3 times, and the amount that decoction water is added every time is medicine
10～20 times of material gross weight, collecting decoction mixes be concentrated into crude drug total amount 0.5 times with 1) Chinese medicine liquid, adds ethanol, makes
The content of alcohol precipitates 12h up to 60%.After reclaiming ethanol, ethanol is added, makes alcohol content up to 70%, precipitate 12h, reclaim ethanol,
Extract is obtained final product, is refrigerated standby；3) addition antioxidant bisulfite in the case that appropriate water for injection heats while stirring is taken
After sodium 36g dissolvings, be cooled to less than 40 DEG C, in adding 1) volatile oil of extraction and 2) in prepared extract, stir,
Add appropriate Tween-80 to make solution clear and bright, stir rapidly under nitrogen charging state to being completely dissolved, adjust pH value to 4.5, plus injection
With water to total amount 10000ml, filter, packing, nitrogen charging, sealing, sterilizing obtains final product oral liquid.
Embodiment 4
20 parts of thizoma curculiginis, 15 parts of the bark of eucommia, 15 parts of semen astragali complanati, 10 parts of stamen nelumbini, 10 parts of motherwort, 10 parts of Chinese trumpet creeper, 10 parts of Radix Codonopsis,
5 parts of the bighead atractylodes rhizome, 5 parts of the root of kudzu vine.
Preparation process is as follows：20 parts of thizoma curculiginis, 15 parts of the bark of eucommia, 15 parts of semen astragali complanati, 10 parts of stamen nelumbini, 10 parts of motherwort, Chinese trumpet creeper
10 parts, 10 parts of Radix Codonopsis, 5 parts of the bighead atractylodes rhizome, 5 parts of the root of kudzu vine medicinal material of grade 9 adds 10～and 20 times of amount decoctings boil three times, 1～3 hour every time, close
And decoction liquor, filtration, stand overnight, leaching supernatant, it is evaporated to relative density 1.21～1.27 (50 DEG C), is dried to do
Cream.Dry cream crushed 100 mesh sieves, plus appropriate dextrin is mixed, plus adhesive, granulation, made granule.
Embodiment 5
20 parts of thizoma curculiginis, 15 parts of the bark of eucommia, 15 parts of semen astragali complanati, 10 parts of stamen nelumbini, 10 parts of motherwort, 10 parts of Chinese trumpet creeper, 10 parts of Radix Codonopsis,
5 parts of the bighead atractylodes rhizome, 5 parts of the root of kudzu vine.
Preparation process is as follows：Respectively take 15 parts of the bark of eucommia, 15 parts of semen astragali complanati, 10 parts of stamen nelumbini, 10 parts of Chinese trumpet creeper, 10 parts of Radix Codonopsis, white
The taste medicinal material of 5 parts of grades of art 6, plus 10～20 times of amount water, distills 2～8 hours, extracts volatile oil, and the another device of volatile oil is collected, volatile oil with
Beta-schardinger dextrin is with 1：10 inclusions, it is standby；The dregs of a decoction after extraction, with 20 parts of thizoma curculiginis, 10 parts of motherwort, 5 parts of the root of kudzu vine, plus 10～20 times
Amount decocting is boiled 1～3 time, 1～3 hour every time, merges decoction liquor, is filtered, and is evaporated to relative density 1.15～1.27 (50
DEG C), dry, pulverize, 100 mesh sieves are crossed, dried cream powder mixes with volatile oil beta cyclodextrin inclusion complex, adds appropriate dextrin to mix, plus
Adhesive, granulation, makes granule.
Test example 1
Treatment results of this Chinese medicine to sow infertility：
Experimental animal：Body weight is up to 130kg length out of heat is white, great Bai replacement gilts 100.
Test method：Above-mentioned 100 sow stochastic averaginas are divided into 4 groups, respectively control group, I group of test, II group of test
With test III group.
Control group fed basal diet.Chinese medicine composition prepared by I group of method of feeding embodiment 1 is tested, according to base per ton
Plinth daily ration addition 3% carries out spice feeding treatment, is within 5 days a course for the treatment of；Test the Chinese medicine group that II group of feeding removes monarch drug in a prescription thizoma curculiginis
Compound, preparation method and feeding method are with I group of test；Test the Chinese medicine composition that III group of feeding removes the ministerial drug bark of eucommia, preparation side
Method and feeding method are with I group of test.
The Chinese medicine composition promoted the sexual maturity using the made livestock and poultry of above-described embodiment is treated to sow out of heat, be the results are shown in Table
1st, table 2.
Table 1 is promoted the sexual maturity the promote the sexual maturity effect of the Chinese medicine compound prescription to sow of progestogenic
Note：*：Represent P<0.05.
Table 2 is promoted the sexual maturity the impact of the Chinese medicine compound prescription to sows farrowing situation of progestogenic
Result of the test shows that the present invention significantly improves Oestrus rate, fertilization of the body weight up to replacement gilt 130kg out of heat
Rate, the strong subnumber of farrowing rate, product is all significantly higher than control group.Meanwhile, significantly reduce weak young number, stillborn foetus number and mummy number.Remove
Monarch drug in a prescription and make after medicine, as a result with control group without significant changes, but test III group of result better than II group of test.As a result show, this
Bright composition effect preferably, lacks monarch drug in a prescription, result after medicine is declined.
Experimental example 2
Therapeutic effect of the present invention to infertile milk cow
Experimental animal：3～5 months postpartum milk cow out of heat 160, is divided into 4 groups, each 40.Respectively control group, test
III group of I group, II group of test and test.
Test method：Control group fed basal diet.Chinese medicine composition prepared by I group of method of feeding embodiment 1 is tested, is pressed
Spice feeding treatment is carried out according to basal diet per ton addition 3%, is within 5 days a course for the treatment of；Test II group of feeding and remove monarch drug in a prescription thizoma curculiginis
Chinese medicine composition, preparation method and feeding method are with I group of test；Test the Chinese traditional medicine composition that III group of feeding removes the ministerial drug bark of eucommia
Thing, preparation method and feeding method are with I group of test.
The milk cow out of heat to different time is treated for the Chinese medicine composition promoted the sexual maturity using the made livestock and poultry of above-described embodiment,
The results are shown in Table 3.
Table 3 is promoted the sexual maturity the impact of the Chinese medicine compound prescription to the treatment of milk cow weary feelings of progestogenic
Note：*：Represent P<0.05.
Result of the test shows, after weary 1 course for the treatment of of feelings of compound of Chinese herbal medicine milk cow of the present invention, average estrus rate reaches 90%,
Total cure rate is 88.9%, and control group average estrus rate is 52%, and heat milk cow conception rate is 61.5%.Test I group averagely to send out
, all apparently higher than control group, with control group without significant difference, III group of test is better than control group for II group of test for feelings rate and total cure rate
With test II group, therapeutic effect is poorer than I group of test.Thus prove, the Chinese medicine composition of the present invention just has good rush of promoting the sexual maturity entirely
Pregnant effect, lacks monarch drug in a prescription therein or makes medicine, can all have influence on final therapeutic effect.
The above, is only presently preferred embodiments of the present invention, and any pro forma restriction is not made to the present invention, this
Art personnel make a little simple modification, equivalent variations or modification using the technology contents of the disclosure above, all fall within this
In bright protection domain.
Claims (10)
1. a kind of Chinese medicine composition of progestogenic of promoting the sexual maturity, it is characterised in that be prepared from by the Chinese medicine material medicine of following weight proportion：
15～25 parts of thizoma curculiginis, 10～20 parts of the bark of eucommia, 10～20 parts of semen astragali complanati, 5～15 parts of stamen nelumbini, 5～15 parts of motherwort, Chinese trumpet creeper 5～
15 parts, 5～15 parts of Radix Codonopsis, 1～10 part of the bighead atractylodes rhizome, 1～10 part of the root of kudzu vine.
2. Chinese medicine composition according to claim 1, it is characterised in that prepared by the Chinese medicine material medicine of following weight proportion
Form：18～22 parts of thizoma curculiginis, 13～18 parts of the bark of eucommia, 8～12 parts of semen astragali complanati, 8～12 parts of stamen nelumbini, 8～12 parts of motherwort, Chinese trumpet creeper
8～12 parts, 2～8 parts of Radix Codonopsis, 2～8 parts of the bighead atractylodes rhizome, 2～8 parts of the root of kudzu vine.
3. Chinese medicine composition according to claim 1, it is characterised in that prepared by the Chinese medicine material medicine of following weight proportion
Form：20 parts of thizoma curculiginis, 15 parts of the bark of eucommia, 15 parts of semen astragali complanati, 10 parts of stamen nelumbini, 10 parts of motherwort, 10 parts of Chinese trumpet creeper, 10 parts of Radix Codonopsis, in vain
5 parts of art, 5 parts of the root of kudzu vine.
4. Chinese medicine composition according to claim 1, it is characterised in that the Chinese medicine composition be tablet, capsule,
Granula, pill, paste, solution, injection, suppository, spray, drops or patch.
5. the preparation method of the Chinese medicine composition described in claim 1, it is characterised in that the method comprising the steps of：
First, thizoma curculiginis, the bark of eucommia, semen astragali complanati, stamen nelumbini, motherwort, Chinese trumpet creeper, Radix Codonopsis, the bighead atractylodes rhizome and the root of kudzu vine are placed in decoction vessel, are added water
Decoction obtains decoction liquor；
2nd, the decoction liquor in step one is filtered, stands 8～12h, take supernatant, be evaporated under the conditions of 50 DEG C relatively close
Spend for 1.21～1.27, drying makes dry cream；
3rd, after the dry cream in step 2 is pulverized and sieved, add dextrin to mix, that is, be obtained and promoted the sexual maturity the answering of progestogenic for domestic animal
Square Chinese medicine.
6. the preparation method of Chinese medicine composition according to claim 5, it is characterised in that the water in the step one is to steam
Distilled water or deionized water.
7. the preparation method of Chinese medicine composition according to claim 5, it is characterised in that the side decocted in the step one
Method is the water for adding 8～20 times of quality of medicinal material, is boiled 2～3 times, and 2～4h is boiled every time；Rear separating filtrate filter residue is boiled every time,
The water of 10 times of quality of medicinal material is added to be boiled next time in filter residue.
8. the preparation method of Chinese medicine composition according to claim 5, it is characterised in that decoct in the step one when
Between be 2h.
9. the preparation method of Chinese medicine composition according to claim 5, it is characterised in that the hole sieved in the step 3
Footpath is 100 mesh.
10. Chinese medicine composition according to claim 1 is promoted the sexual maturity progestogenic for domestic animal, treatment domestic animal insufficiency of vital energy and blood, is not sent out long
The symptom such as feelings or post-partum estrus be slow.
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| CN113693023A (en) * | 2021-09-03 | 2021-11-26 | 河南省农业科学院畜牧兽医研究所 | Processing method for improving group entering efficiency of replacement gilts with no estrus exceeding period |
-
2016
- 2016-12-29 CN CN201611243073.9A patent/CN106620066A/en active Pending
Non-Patent Citations (1)
| Title |
|---|
| 杨保田等: "中草药饲料添加剂对母羊繁殖性能的影响", 《中国兽药杂志》 * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN113693023A (en) * | 2021-09-03 | 2021-11-26 | 河南省农业科学院畜牧兽医研究所 | Processing method for improving group entering efficiency of replacement gilts with no estrus exceeding period |
| CN113693023B (en) * | 2021-09-03 | 2022-09-02 | 河南省农业科学院畜牧兽医研究所 | Processing method for improving group entering efficiency of replacement gilts with no estrus in excess period |
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