WO2012031525A1

WO2012031525A1 - Traditional chinese medicine composition for promoting oestrus and assisting pregnancy

Info

Publication number: WO2012031525A1
Application number: PCT/CN2011/078900
Authority: WO
Inventors: 陈鹏举; 张光辉; 谢二伟
Original assignee: 漯河市宇信生物科技有限公司
Priority date: 2010-09-07
Filing date: 2011-08-25
Publication date: 2012-03-15
Also published as: CN101940665B; LU91983B1; CN101940665A

Abstract

A traditional Chinese medicine composition for promoting oestrus and assisting pregnancy, mainly comprising the following traditional medicinal ingredients having the following parts by weight: 12-18 parts of Fructus Lycii, 20-36 parts of Fructus Ligustri Lucidi, 12-18 parts of Radix Dipsaci, 8-12 parts of Radix Angelicae Sinensis, 15-25 parts of Rhizoma Cibotii, 8-15 parts of Radix Morindae Officinalis, 15-25 parts of Herba Epimedii, 8-15 parts of fried Cortex Eucommiae, 20-36 parts of fried Semen Cuscutae, 12-18 parts of Rhizoma Chuanxiong, 12-18 parts of Radix Rehmanniae Preparata. Said Chinese medicine composition can ameliorate infertility of maternal livestock or beasts, and increase breeding rates.

Description

Traditional Chinese medicine composition for promoting pregnancy and helping pregnancy

Technical field

The invention belongs to the technical field of veterinary medicine, and particularly relates to a traditional Chinese medicine composition for treating a female animal or a mother animal without estrus and repeated infertility after childbirth.

Background technique

With the continuous strengthening of the national economy, people's food consumption structure has also quietly changed. The most prominent is the gradual growth of meat consumption. On the other hand, the demand for animal skin is also in great conflict with the increasing awareness of wildlife protection. In order to match the actual needs of people, the aquaculture industry must continue to expand production scales to produce more and better animal foods and furs. The mascot or mother animal as a producer in the breeding chain is a key player in ensuring the healthy development of the aquaculture industry. However, frequent stress stimuli cause the dam or mother to remain in a sub-healthy state for a long time, and the performance is degraded. In the animal husbandry industry, problems such as low reproductive rate, postpartum estrus or repeated infertility are very common, causing great economic losses to aquaculture companies or farmers.

For the infertility of dams and mothers, antibiotics or perfusion therapy are often used, and the effect is not obvious. If hormonal drugs such as diethylstilbestrol and estradiol are used for treatment, it is easy to cause wigs or infertility. It is also prone to drug residues, posing a hidden danger to food safety.

Chinese medicine believes that the kidney is the main collector. Fine, also known as essence, is the most basic substance that constitutes the human body, promotes human growth and development, and maintains human life activities. It is the source of life, so "Su Wen·Jin Zhenzhen's Remarks" said: "Feng Jing, the birth of life and also". Storage and sealing of essential gas are the most important physiological functions of the kidney. The essence is hidden in the kidney, exerting its physiological effects without loss of no reason, relying on the coordination of the renal gas and the coordination of the stimulating effects. Therefore, Chinese medicine practitioners often start with the treatment of kidneys in the treatment of sexual desire, estrus, and gestation.

In addition, according to the records of the Emperor's Internal Classic, "Women are seven years old, the kidneys are full, the teeth are longer; the twenty-seven and the heavens are coming, Renmaitong, Taichongmaisheng, the moon is now, so there is a son; , kidney gas average, so the real teeth are born and long; Siqi, strong bones, long poles, body is strong; Wuqi, Yangming pulse decline, face start Jiao, start to sputum; Liuqi, Sanyang pulse decline On the top, the face is burnt, the beginning is white; seven seven, Renmai deficiency, too small pulse decay, the sky is exhausted, the tunnel is impassable, the shape is bad and there is no child. "It can be seen that lust, gestation and rushing , Renmai and other meridians related, as the main cell is pregnant, "Chongmai" is the leader of a qi and blood, for the sea of the twelfth century ("Su Wen-Ancient naive theory" has "rushed into the bloody sea"), To regulate the blood of these meridians, to make it unimpeded, to promote the necessary methods of pregnancy.

Summary of the invention

The object of the present invention is to provide a traditional Chinese medicine composition for promoting female pregnancy, such as cows, sheep, donkeys, pigs, camels, foxes, baboons, baboons, rabbits and the like. To achieve this goal, the technical solution adopted by the present invention is: a traditional Chinese medicine composition for promoting pregnancy and promoting pregnancy, mainly comprising the following Chinese herbal medicines: 12 to 18 servings of hazelnuts and 20 to 36 servings of hazelnuts. 12~18 servings, 8~12 servings of Angelica, 15-25 servings of dog ridges, 8-15 servings of Morinda citrifolia, 15-25 servings of Epimedium, 8-15 servings of fried Eucommia, 20-36 portions of fried scallions, 12-18 parts of Chuanxiong and 12~18 parts of Rehmannia glutinosa.

The composition further comprises: 4 to 8 parts of Amomum villosum, 12 to 18 parts of Ai Ye, 8 to 12 parts of Astragalus, 12 to 18 parts of Mulberry, 8 to 15 parts of Ejiao, 7 to 12 pieces of Magnolia, and 7 to 12 pieces of Musk. 12 parts, 20~36 parts of white peony, 4~8 parts of Baiwei, 1.5~2.6 parts of fried atractylodes, 12~18 parts of astragalus, and 12~18 parts of mulberry.

In the upper part, Du Zhonggan, Wen, return to the liver, kidney, with liver and kidney, strong bones, and fetus. With its liver and kidney, strong bones and bones, kidney deficiency and low back pain are particularly suitable; other low back pains are used, all have the effect of strengthening the body. Pregnancy fetal dysphoria or habitual abortion, with this product tonic liver and kidney solid Chong Rentai tire has a very good effect. Stir-fry to destroy its gum is beneficial to the effective ingredients to fry, so it is better than the raw.

Cuscuta, sweet, warm, liver, kidney, spleen. It can nourish kidney and improve essence, nourish liver and improve eyesight, good governance of waist and knee pain, weakness of legs and feet, impotence and nocturnal emission, frequent urination, dizziness, tinnitus and deafness, and women with habitual abortion.

Epimedium, Xin, Gan, warm, liver, kidney, can replenish kidney yang, strong bones, rheumatism, treatment of impotence, infertility or due to liver and kidney deficiency caused by muscles and muscles, rheumatism, numbness and other evidence .

Bayu Tian, Wei Xin, Gan, sexual lukewarm, kidney, liver. The medicine can warm the kidney and strengthen the muscles and strengthen the bones, and also the Xin Wen, can be rheumatism and remove the pain, so the impotence of the kidney yang, infertility, irregular menstruation, less abdominal pain and liver and kidney deficiency Soft, waist and knee pain, rheumatism and long-term symptoms can be applied.

Dog ridge tastes bitter, sweet, warm, liver, kidney, attending rheumatic pain, weak waist, lower limb weakness, frequent urination, enuresis, leucorrhea and other symptoms. At the same time, the dog ridge also has the function of slowing the stomach.

It is sweet and mellow, and it can be used to replenish liver and kidney, benefit essence and blood, improve eyesight, and quench thirst. It is a common medicine for treating kidney deficiency and nocturnal emission, liver and kidney yin deficiency, blurred vision and diabetes.

Female scorpion Gan, slightly bitter, flat, into the liver, kidney, can nourish yin and kidney, nourish liver and eyesight. This product is often used in the Yin of the liver and kidney, to strengthen the waist and knees, eyesight.

Rehmannia radicans are sweet, warm, and return to the liver and kidney. After the rehmannia is processed, the bitterness is changed to sweetness, and the medicinal properties are changed from slightly cold to slightly warm, which is the yang in the yin, so it can replenish the kidney. Modern research has shown that Rehmannia glutinosa contains obvious immunosuppressive activity, as well as significant cardiac, diuretic, liver-protecting, hypoglycemic, anti-proliferative, anti-exudation, anti-inflammatory, anti-fungal, anti-radiation, etc. effect.

Chuanchuan (continued) is bitter, pungent, mild, and liver, kidney. According to the records of "Southern Materia Medica", the continuation of the spleen can "reinforcing the liver, strengthening the bones, strengthening the meridians, stopping the menstruation (reinforcing the bones), soothing, curing the fetus, treating the leucorrhea, creating new blood, breaking blood, falling dead, stop Cough, hemoptysis, cure redness and turbidity."

Chuanxi Xin, Wen, into the liver, gallbladder, pericardium, with blood circulation, hurricane and pain relief, difficult to treat qi and blood stasis Production, fetal clothes are not good, often with Angelica, red peony, peach kernel, safflower. Angelica sinensis, Xin, bitter, warm, into the liver, spleen, heart. This product can not only blood, but also blood circulation, can be used for frail blood deficiency syndrome; Angelica can also promote blood circulation and relieve pain and laxative.

Eucommia, Bayu Tian, Dodder, Epimedium, dog ridge warm kidney and help Yang, is for the drug; the drug scorpion, the scorpion, the rehmannia glutinosa, the lukewarm, can enter the kidney to help the yin; the complement of yin and yang, water and fire Take the root cause. Chuanchuan, Chuanxiong, Angelica as the adjuvant, blood treatment to Tongli Ren pulse pulse. The kidneys are full, the blood is smooth, and there is no reason for infertility. The addition of Amomum villosum L., Ai Ye, Astragalus, Mulberry, Ajiao, Magnolia, Musk, Angelica, Baiwei, Atractylodes Rhizome, Astragalus, Mulberry and other medicinal herbs can further enhance the curative effect, with Ai Ye as the icing on the cake.

According to the Chinese veterinary syndrome differentiation theory, the traditional Chinese medicine composition of the invention can be conditioned from the root of the animal body, and can better change the vicious circle of infertility of the female animal or the mother animal, and the cow, the sheep, the donkey, the pig, the camel , the fox, scorpion, scorpion, rabbit and other female or female beasts have infertility, estrus instability, warp thinning, repeated infertility and other symptoms have a good effect. At the same time, the traditional Chinese medicine composition can also increase the reproduction rate of the female animal or the mother animal. The medicament of the invention is a pure Chinese medicine product, which can effectively avoid the problems of anti-milk, drug residue and food safety, and is suitable for promotion in livestock production.

In recent years, the present invention has achieved good curative effect in treating clinical cases, and is described in detail as follows:

First, technical solutions 1 efficacy description

1.1 Drug composition: scorpion 12~18g, female scorpion 20~36g, continuous stalk 12~18g, angelica 8~12g, dog ridge 15~25g, scorpion day 8~15g, epimedium 15~25g, fried eucommia 8~15g, fried scorpion 20~36g, Chuanxiong 12~18g, Rehmannia glutinosa 12~18g, all kinds of medicines are finely passed through 300 mesh sieve, which is a powder.

1.2 Method of administration: Oral administration of the mixture; one daily dose of large livestock such as cattle, horses, camels, 1/2 dose of pigs and sheep daily, 1/4 dose of fox, cockroach, cockroach, etc., 1/6 of rabbit daily Agent, after 5 days of use.

1.3 Determination of curative effect: taking the medicine within 15 days and accepting the breeding, after confirming that the successful breeding is regarded as a cure; 30 within the estrus and successful breeding is considered effective, otherwise it is invalid.

1.4 efficacy statistics:

Table 1 Technical Scheme 1 Statistics on the treatment results of non-estrus females (mothers)

Table 2 Technical Scheme 1 Statistics on treatment outcomes of estrus but repeated infertile females

Second, technical solutions 2 efficacy description

1.1 Drug composition: scorpion 12~18g, female scorpion 20~36g, continuous stalk 12~18g, angelica 8~12g, dog ridge 15~25g, scorpion day 8~15g, epimedium 15~25g, fried eucommia 8~15g, fried dodder 20~36g, Chuanxiong 12~18g, Rehmannia glutinosa 12~18g, Amomum vulgaris 4~8g, Ai Ye 12~18g, Astragalus 8~12g, Mulberry 12~18g, Ejiao 8~15g, Magnolia 7~12g, musk 7~12g, white peony 20~36g, Baiwei 4~8g, fried atractylodes 1.5~2.6g, astragalus 12~18g, mulberry 12~18g, all kinds of medicines are finely sieved through 300 mesh. It is a powder.

1.2 Medication method: Mixture orally; one daily dose of large livestock such as cattle, horses, camels, 1/3 of daily dose of pigs and sheep, 1/4 dose of fox, cockroach, cockroach, etc., 1/6 of rabbit daily Agent, after 5 days of use.

1.4 efficacy statistics:

Table 3 Technical Plan 2 Statistics on the treatment results of non-estrus females (mothers)

Table 4 Technical Plan 2 Statistics on treatment outcomes of estrus but repeated infertile females

detailed description

Example 1

A traditional Chinese medicine composition for promoting pregnancy and gestation, comprising: scorpion 16g, scorpion 25g, continuous stalk 16g, angelica 10g, Dog ridge 25g, Morinda 15g, Epimedium 18g, fried Eucommia 10g, fried dodder 28g, Chuanxiong 16g, Rehmannia glutinosa 16g. Example 2

A traditional Chinese medicine composition for promoting pregnancy and gestation, consisting of: medlar 12g, Ligustrum lucidum 20g, Dipsa 12g, Angelica 8g, Dog Ridge 15g, Basil Day 8g, Epimedium 15g, Fried Eucommia 8g, Fried Dodder 20g, Chuanxiong 12g, Rehmannia glutinosa 12g, Amomum villosum 4g, Ai Ye 12g, Astragalus 8g, Mulberry 12g, Ejiao 8g, Magnolia 7g, Musk 7g, White Pelican 20g, Baiwei 4g, Atractylodes Rhizome 1.5g, Astragalus 12g, Mulberry 12g.

Example 3

A traditional Chinese medicine composition for promoting pregnancy, consisting of: medlar 15g, Ligustrum lucidum 30g, continuous stalk 15g, angelica 10g, dog ridge 20g, scorpion 12g, epimedium 20g, fried eucommia 12g, fried dodder 30g, Chuanxiong 15g, Rehmannia glutinosa 15g, Amomum vulgaris 6g, Ai Ye 15g, Astragalus 10g, Mulberry 15g, Ejiao 12g, Magnolia 9g, Musk 9g, White peony 30g, Baiwei 6g, Atractylodes macrocephala 2g, Astragalus 15g, Mulberry 15g.

Example 4

A traditional Chinese medicine composition for promoting pregnancy, consisting of: medlar 18g, female medlar 36g, continuous squid 18g, angelica 12g, dog ridge 25g, scorpion 15g, epimedium 25g, fried eucommia 15g, fried dodder 36g, Chuanxiong 18g, Rehmannia glutinosa 18g, Amomum 8g, Ai Ye 18g, Astragalus 12g, Mulberry 18g, Ejiao 15g, Magnolia 12g, Musk 12g, White peony 36g, Baiwei 8g, Atractylodes Rhizome 2.5g, Astragalus 18g, Mulberry 18g.

Example 5

A traditional Chinese medicine composition for promoting pregnancy, consisting of: medlar 15g, Ligustrum lucidum 20g, continuous stalk 15g, angelica 10g, dog ridge 15g, scorpion 10g, epimedium 25g, fried eucommia 15g, fried dodder 35g, Chuanxiong 15g, Rehmannia glutinosa 18g, Astragalus 10g, White Pelican 25g, Fried Atractylodes 1.6g, Astragalus 15g, Ejiao 8g.

Example 6

A traditional Chinese medicine composition for promoting pregnancy and gestation, consisting of: 15 scorpions, 25 scorpions, 15 sequels, 10 angelica, 20 dog ridges, 10 scorpio days, 20 sinensis 10 parts of fried Eucommia, 35 parts of fried scallions, 12 parts of Chuanxiong, 15 parts of Radix Rehmanniae, 8 parts of Amomum villosum L., 10 parts of Artemisia argyi, 10 parts of Astragalus, 10 parts of Astragalus, 15 parts of Mulberry, 8 parts of Ejiao, 10 parts of Magnolia, 10 parts of Musk 10 Serving, 25 parts of white peony, 8 parts of Bai Wei, 2.6 parts of fried atractylodes, 15 parts of astragalus, 15 parts of mulberry.

Case 1

In 2006, Dengzhuang Village, Guanzhuang Township, Yinan County, Zhumadian City, Henan Province, the livestock owner Deng Mou’s 5-year-old cow had postpartum lochia, and the local veterinarian used potassium permanganate to clean the uterus and intrauterine administration of streptomycin. , healed after 7 days of treatment. However, in the subsequent estrus period, the breeding was not carried out three times, the rectum was examined, the ovulation was normal, and the uterus was swollen. Take the amount of the drug of Example 2 daily, smash it, suspend it with water, puff it, use it for 5 days, and then conceive. Case 2

On November 12, 2007, the veterinary station of the Liangshan Park in Shangqiu City, Henan Province, was reported by the owner Wang. The 3-year-old cow in his family had no placenta for 5 days after childbirth, and then the local veterinarian used the method of uterus to clear the palace. Treatment for 3 days. However, no breeding was performed three times during the subsequent estrus. Suspected that there was an infection in the uterus when the sputum was taken, the smash of the sample of Example 3 was pulverized and the mixture was fed for three days, and the streptomycin was injected for 5 days, and then the pregnancy was carried out.

Case 3

In 2008, a 2 year old and a half young cow in the Henan Dairy Breeding Center did not estrus after 90 to 120 days of calving. After subcutaneous injection of chorionic gonadotropin (HCG) 500~20 000 IU, it began to estrus. But with 2 times, you can't conceive. The dosage of the sample of Example 4 was taken daily and the mixture was smashed and fed for 5 days. At the same time, the streptomycin was injected during the feeding, and then the pregnancy was carried out.

Case 4

In 2009, the 2nd-year-old sow of the owner Chen was artificially inseminated after estrus, but it was often infertile, ovulation was normal, the uterus was swollen, and progesterone was lacking. The amount of the sample of Example 1 was pulverized, half a dose per day, and the mixture was fed for 4 days, and then was pregnant.

Case 5

In February 2010, 32 of the 682 foxes that were bred by Zhao’s fox breeder in Changli County, Hebei Province, did not estrus. After the examination, the number of ovulations was low and the uterus was swollen. The amount of the sample of Example 6 was pulverized, 1/4 dose per day, and the mixture was fed for 5 days, and then was pregnant.

Case 6

In July 2010, 72 of the 960 rex rabbits that were raised by Li, a specialized rabbit breeder in Xiping County, Henan Province, were estrus but not pregnant. After examination, the ovarian function was reduced and the number of ovulation was low. The amount of the sample of Example 5 was pulverized, 1/6 of the dose per day, and the mixture was fed for 5 days, and then was pregnant. And

Claims

WO 2012/031525 Claim PCT/CN2011/078900, a traditional Chinese medicine composition for promoting pregnancy, mainly comprising the following Chinese herbal medicines: 12 to 18 hazelnuts, 20 to 36 hazelnuts, continued 12~18 servings, 8~12 servings of Angelica, 15~25 servings of dog ridges, 8~15 servings of Basil, 15~25 parts of Epimedium, 8~15 parts of fried Eucommia, 20~36 parts of fried scallions, Chuanxiong 12~18 parts, 12~18 parts of Rehmannia glutinosa.

The traditional Chinese medicine composition according to claim 1, wherein the composition further comprises: 4 to 8 parts of Amomum villosum, 12 to 18 parts of Ai Ye, 8 to 12 parts of Astragalus, and 12 to 18 pieces of Mulberry. 8 parts, Ejiao 8~15 parts, Magnolia 7~12 parts, Musk 7~12 parts, White peony 20~36 parts, Baiwei 4~8 parts, Fried atractylodes 1.5~2.6 parts, Astragalus 12~18 parts, Mulberry 12~18 servings.