CN108635494A - It is a kind of to be used to treat Chinese medicine of barrenness of milk cow and its preparation method and application - Google Patents

It is a kind of to be used to treat Chinese medicine of barrenness of milk cow and its preparation method and application Download PDF

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CN108635494A
CN108635494A CN201810663610.8A CN201810663610A CN108635494A CN 108635494 A CN108635494 A CN 108635494A CN 201810663610 A CN201810663610 A CN 201810663610A CN 108635494 A CN108635494 A CN 108635494A
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chinese medicine
milk cow
barrenness
treating
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石国剑
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Jiangsu Hundred Sword Pharmaceutical Technology Co Ltd
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Jiangsu Hundred Sword Pharmaceutical Technology Co Ltd
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/29Berberidaceae (Barberry family), e.g. barberry, cohosh or mayapple
    • A61K36/296Epimedium
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/232Angelica
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/23Apiaceae or Umbelliferae (Carrot family), e.g. dill, chervil, coriander or cumin
    • A61K36/234Cnidium (snowparsley)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/487Psoralea
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/53Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
    • A61K36/533Leonurus (motherwort)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/65Paeoniaceae (Peony family), e.g. Chinese peony
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/71Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/74Rubiaceae (Madder family)
    • A61K36/746Morinda
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/80Scrophulariaceae (Figwort family)
    • A61K36/804Rehmannia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/81Solanaceae (Potato family), e.g. tobacco, nightshade, tomato, belladonna, capsicum or jimsonweed
    • A61K36/815Lycium (desert-thorn)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/89Cyperaceae (Sedge family)
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/896Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8962Allium, e.g. garden onion, leek, garlic or chives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis

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Abstract

The invention discloses a kind of Chinese medicine preparations for treating barrenness of milk cow, it includes the component of following parts by weight:80 120 parts of celestial woods spleen, 40 60 parts of Radix Angelicae Sinensis, 45 60 parts of psoralea corylifolia, 45 60 parts of radix rehmanniae preparata, 50 60 parts of radix paeoniae rubra, 50 60 parts of green onion garlic, 46 60 parts of the fruit of Chinese wolfberry, 45 60 parts of rhizoma cyperi, 90 110 parts of motherwort, 40 50 parts of thizoma curculiginis, 40 50 parts of frutus cnidii, 40 50 parts of Morinda officinalis.Chinese medicine preparation of the present invention is to use tonifying kidney and strengthening yang, and dredging collateral and promoting blood circulation, stasis eliminatings give birth to new Chinese medicinal composition prescription, can adjust the intrinsic regulating power of body, promote the recovery of sexual performance, so static to fresh cow ovary, retained corpus luteum infertility is by obvious curative effects.

Description

It is a kind of to be used to treat Chinese medicine of barrenness of milk cow and its preparation method and application
Technical field
The present invention relates to field of Chinese herbal, and in particular to a kind of for treating Chinese medicine of barrenness of milk cow and preparation method thereof And application.
Background technology
Barrenness of milk cow is the serious problems for influencing milk cow breeding, is the big obstacle for influencing milk cow development.It is also milk cow The major reason that industry is lost in managing.According to reports, there is 15% milk cow that infertility, China's barrenness of milk cow hair occurs in the world Raw rate is 20% or so.Cause to be mainly uterine disease and disease of ovary in infertile disease.In reproductive diseases, endometrium Infertility caused by inflammation typically constitutes from 70% or so, and ovarian dysfunction (static, retained corpus luteum of ovary etc.) accounts for 30% or so.
Under normal circumstances, it should just become pregnant within 60-90 days after cow calving.If nonpregnant number of days is more than normal after cow production It one month, i.e., is not impregnated within 120 days, it will 300-400 kilograms of milk production less.If 10 months postpartum was impregnated not yet, it is equal to one As soon as head ox foster year in vain, economic loss bigger.So breeding difficulty caused by various reproductive diseases reasons is prevented and treated, The normal breeding for ensureing cows, has important practical significance to the development of Cow product.
There is certain curative effect mainly or using hormone therapy to the treatment of disease of ovary at present.But newborn after use hormone, When there are a certain amount of hormone residues in the high products such as meat, the health of the mankind can be endangered.
Invention content
For overcome the deficiencies in the prior art, it is safely and effectively used to treat milk cow the purpose of the present invention is to provide a kind of The Chinese medicine preparation and its preparation method and application of inactive ovaries and persistentcorpus luteum infertility.
In order to solve the above-mentioned technical problem, the technical solution adopted in the present invention is as follows:
A kind of Chinese medicine for treating barrenness of milk cow, it includes the component of following parts by weight:HERBA EPIMEDII 80-120 Part, 40-60 parts of Radix Angelicae Sinensis, 45-60 parts of psoralea corylifolia, 45-60 parts of radix rehmanniae preparata, 50-60 parts of radix paeoniae rubra, 50-60 parts of green onion garlic, fruit of Chinese wolfberry 46- 60 parts, 45-60 parts of rhizoma cyperi, 90-110 parts of motherwort, 40-50 parts of thizoma curculiginis, 50 parts of frutus cnidii 40-, 40-50 parts of Morinda officinalis.
Using the principle of above-mentioned Chinese medicine preparation:Cow barrenness mainly has kidney-yang deficiency (western beast on Chinese veterinarian's differentiation of symptoms and signs for classification of syndrome It is static that doctor is known as ovary) and qi stagnation and blood stasis type retained corpus luteum.Kidney-yang deficiency ill domestic animal build is become thin more, and mouth color is light white, the thin and delicate nothing of pulse condition Power, hair have some setbacks, unglazed, and urine is limpid, soft stools etc..Its estrogen level of experimental determination is relatively low.Qi stagnation and blood stasis type disease Poultry, performance is red light white or dark and gloomy, and pulse condition is heavy thin, out of heat long, higher according to this kind of ill domestic animal progesterone content of experimental determination.Base In above-mentioned disease type, we use tonifying kidney and strengthening yang, dredging collateral and promoting blood circulation, stasis eliminatings to give birth to new Chinese medicinal composition prescription.
HERBA EPIMEDII, green onion garlic, psoralea corylifolia, thizoma curculiginis are with kidney tonifying Xing Yang, vigorous for kidney;Extravasated blood internal resistance easily occurs for dam postpartum Phenomenon, with Radix Angelicae Sinensis, radix paeoniae rubra, motherwort, rhizoma cyperi to enrich blood, invigorate blood circulation, relieve pain, tune is rushed pregnant two arteries and veins and is given birth to newly with stasis eliminatings, promotes uterus multiple It is former;According to interdependence between yin and yang, mutually limit (then the deficiency of vital energy, Yang Shengyin are gone the deficiency of blood, sun disappear it is cloudy hide, therefore control sun and want Gu Yin) conclusion, Wo Menxuan It is abundant for essence and blood with replenishing essence blood with the fruit of Chinese wolfberry, radix rehmanniae preparata, enriching yin and nourishing kidney;Frutus cnidii warming kidney and enhancing body has similar sex hormone Effect.To sum up, due to the intrinsic regulating power of adjusting body, promote the recovery of sexual performance, so it is quiet to fresh cow ovary Only, retained corpus luteum infertility is by obvious curative effects.
Preferably, above-mentioned Chinese medicine preparation includes the component of following parts by weight:100 parts of HERBA EPIMEDII, 50 parts of Radix Angelicae Sinensis, psoralea corylifolia 50 parts, 50 parts of radix rehmanniae preparata, 50 parts of radix paeoniae rubra, 50 parts of green onion garlic, 50 parts of the fruit of Chinese wolfberry, 50 parts of rhizoma cyperi, 100 parts of motherwort, 50 parts of thizoma curculiginis, snake 60 parts of machine tool, 50 parts of Morinda officinalis.
The above-mentioned preparation method for treating the Chinese medicine of barrenness of milk cow, this method comprises the following steps:
1) it is weighed first, in accordance with the parts by weight of each component, it is spare;
2) by above-mentioned each component crush to get to described for treating the Chinese medicine of barrenness of milk cow.
In step 2), the breaking method is ultramicro grinding method.
The Chinese medicine preparation of above-mentioned treatment infertility is preparing the treatment infertile disease drug of milk cow inactive ovaries and persistentcorpus luteum In application.
Advantageous effect:The present invention has the following advantages:Chinese medicine preparation of the present invention is that tonifying kidney and strengthening yang, dredging collateral and promoting blood circulation is used to go The stasis of blood gives birth to new Chinese medicinal composition prescription, can adjust the intrinsic regulating power of body, promote the recovery of sexual performance, so to postpartum mother Ox ovary is static, and retained corpus luteum infertility is by obvious curative effects.
Specific implementation mode:
Below by embodiment, the present invention is further explained.
Embodiment 1:A kind of Chinese medicine for treating barrenness of milk cow, it includes the component of following parts by weight:HERBA EPIMEDII 100 parts, 50 parts of Radix Angelicae Sinensis, 50 parts of psoralea corylifolia, 50 parts of radix rehmanniae preparata, 50 parts of radix paeoniae rubra, 50 parts of green onion garlic, 50 parts of the fruit of Chinese wolfberry, 50 parts of rhizoma cyperi, 100 parts of motherwort, 50 parts of thizoma curculiginis, 60 parts of frutus cnidii, 50 parts of Morinda officinalis.
When preparation, weighed first by the parts by weight of each component, it is spare;Then above-mentioned each component is passed through into Ultramicro-powder Broken method crush to get to described for treating the Chinese medicine of barrenness of milk cow.
Embodiment 2:A kind of Chinese medicine for treating barrenness of milk cow, it includes the component of following parts by weight:HERBA EPIMEDII 80 parts, 40 parts of Radix Angelicae Sinensis, 45 parts of psoralea corylifolia, 45 parts of radix rehmanniae preparata, 50 parts of radix paeoniae rubra, 50 parts of green onion garlic, 46 parts of the fruit of Chinese wolfberry, 45 parts of rhizoma cyperi, benefit 90 parts of Brittle Falsepimpernel Herb, 40 parts of thizoma curculiginis, 40 parts of frutus cnidii, 40 parts of Morinda officinalis.
When preparation, weighed first by the parts by weight of each component, it is spare;Then above-mentioned each component is passed through into Ultramicro-powder Broken method crush to get to described for treating the Chinese medicine of barrenness of milk cow.
Embodiment 3:A kind of Chinese medicine for treating barrenness of milk cow, it includes the component of following parts by weight:HERBA EPIMEDII 120 parts, 60 parts of Radix Angelicae Sinensis, 60 parts of psoralea corylifolia, 60 parts of radix rehmanniae preparata, 60 parts of radix paeoniae rubra, 60 parts of green onion garlic, 60 parts of the fruit of Chinese wolfberry, 60 parts of rhizoma cyperi, 110 parts of motherwort, 50 parts of thizoma curculiginis, 50 parts of frutus cnidii, 50 parts of Morinda officinalis.
When preparation, weighed first by the parts by weight of each component, it is spare;Then above-mentioned each component is passed through into Ultramicro-powder Broken method crush to get to described for treating the Chinese medicine of barrenness of milk cow.
Beneficial effects of the present invention are proved below by experiment.
1, Chinese medicine preparation of the present invention observes the effect of postpartum is more than three months milk cows out of heat
Test ox selection:35 postpartum milk cow out of heat more than three months is chosen to do experiment, and referred to as test group.
Instructions of taking:Using any one Chinese medicine preparation described in embodiment 1 to embodiment 3;It is rushed with boiling water and waits for temperature It gavages.Some oxen are poor to Chinese medicine palatability, can add the punching of some wheat bran boiling water and wait for temperature from drink.It is daily or the next day it is one, often Agent 500g, it is as a treatment course to even served 3-5 agent, takes observation post administration 20 days or so, and 20 days or so out of heat with regard to tonic (cow oestrus week Phase average out to 21 days), it adds 1-2 agent again when necessary, continues to observe heat ovulation situation.Over the course for the treatment of, feeding standard is raised Management is supported without particular/special requirement.
Efficacy determination:It is effective, heat and No-clay weak interbed or without heat No-clay weak interbed person so that heat and ovulation person can be promoted It is invalid;The person of becoming pregnant that breeds in 3 months is positive effect.
2, Chinese medicine preparation of the present invention to breed three times still not conceptive milk cow the effect of observe
Test ox selection:Choosing 27 breedings, still not conceptive milk cow is done experiment three times, and referred to as test group.
Test group:Using any one Chinese medicine preparation described in embodiment 1 to embodiment 3;Instructions of taking is super with postpartum Cross three months milk cows out of heat.
3, Chinese medicine preparation of the present invention observes the effect of 3 months after body maturation milk cows still out of heat
Test ox selection:3 months milk cows 41 still out of heat after selection body maturation, form test group.
Test group:Using any one Chinese medicine preparation described in embodiment 1 to embodiment 3;Instructions of taking is super with postpartum Cross three months milk cows out of heat.
In conclusion Chinese medicine preparation of the present invention is more than three months milk cows out of heat for postpartum, breeds and still cannot three times After the milk cow become pregnant, body maturation 3 months milk cows still out of heat restore heat, breeding aspect of becoming pregnant has good effect.
The above is only a preferred embodiment of the present invention, it should be pointed out that:Those skilled in the art are come It says, various improvements and modifications may be made without departing from the principle of the present invention, these improvements and modifications also should be regarded as Protection scope of the present invention.

Claims (5)

1. a kind of Chinese medicine for treating barrenness of milk cow, which is characterized in that it is grouped as by the group of following parts by weight:Celestial spirit 80-120 parts of spleen, 40-60 parts of Radix Angelicae Sinensis, 45-60 parts of psoralea corylifolia, 45-60 parts of radix rehmanniae preparata, 50-60 parts of radix paeoniae rubra, 50-60 parts of green onion garlic, Chinese holly 46-60 parts of matrimony vine, 45-60 parts of rhizoma cyperi, 90-110 parts of motherwort, 40-50 parts of thizoma curculiginis, 40-50 parts of frutus cnidii, Morinda officinalis 40-50 Part.
2. the Chinese medicine according to claim 1 for treating barrenness of milk cow, which is characterized in that it is by following parts by weight Group be grouped as:100 parts of HERBA EPIMEDII, 50 parts of Radix Angelicae Sinensis, 50 parts of psoralea corylifolia, 50 parts of radix rehmanniae preparata, 50 parts of radix paeoniae rubra, 50 parts of green onion garlic, matrimony vine 50 parts of son, 50 parts of rhizoma cyperi, 100 parts of motherwort, 50 parts of thizoma curculiginis, 60 parts of frutus cnidii, 50 parts of Morinda officinalis.
3. the preparation method according to claim 1 for treating the Chinese medicine of barrenness of milk cow, which is characterized in that this method Include the following steps:
1) it is weighed first, in accordance with the parts by weight of each component, it is spare;
2) by above-mentioned each component crush to get to described for treating the Chinese medicine of barrenness of milk cow.
4. the preparation method according to claim 3 for treating the Chinese medicine preparation of barrenness of milk cow, which is characterized in that step It is rapid 2) in, the breaking method be ultramicro grinding method.
5. the Chinese medicine for the treatment of infertility according to claim 1 is preparing treatment milk cow inactive ovaries and persistentcorpus luteum not Application in pregnant disease drug.
CN201810663610.8A 2018-06-25 2018-06-25 It is a kind of to be used to treat Chinese medicine of barrenness of milk cow and its preparation method and application Withdrawn CN108635494A (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114601874A (en) * 2022-03-18 2022-06-10 内蒙古淘布韦特农牧业科技有限公司 Traditional Chinese medicine preparation for treating cow infertility

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114601874A (en) * 2022-03-18 2022-06-10 内蒙古淘布韦特农牧业科技有限公司 Traditional Chinese medicine preparation for treating cow infertility

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